circRNA basic information
circBase ID: mmu_circ_0011319
Name: mmu_circ_CDC42
Synonym: circCDC42
Host Gene: CDC42
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0030602
Mondo Name: Klebsiella pneumonia
Disease details:
 Klebsiella pneumoniae infection
Disease DO ID: 13272
Disease MeSH ID: -
Disease NCIt ID: -
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Mus musculus
Sample Source: animal tissue
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: alveolar macrophages
Detected method:
primary cell isolation + qRT-PCR; cell-type co-localization
Description:

circCDC42/mmu_circ_0011319 is increased in KP-infected murine alveolar macrophages and localizes to AMs by FISH with the AM marker SiglcF. Its encoded CDC42-165aa promotes Pyrin inflammasome-mediated macrophage pyroptosis and inflammatory responses.
Other information
Title:

CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation.

Journal: Nature communications
Published: 2024
PubMed ID: 38977695
Data availability: PRJNA984001