circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005463
Mondo Name: aortic valve calcification
Disease details:
 Calcific aortic valve disease
Disease DO ID: -
Disease MeSH ID: -
Disease NCIt ID: -
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
UN
Cell type: other
Cell type details: aortic valve interstitial cells (AVICs)
Detected method:
primary cell isolation + qRT-PCR
Description:

In primary human aortic valve interstitial cells, qRT-PCR after nuclear/cytoplasmic fractionation and FISH showed that circHIPK3 is primarily cytoplasmic. Functional experiments in AVICs indicated that circHIPK3 inhibited the osteogenic response.
Other information
Title:

Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions.

Journal: Experimental & molecular medicine
Published: 2024
PubMed ID: 38945954
Data availability: -