circRNA basic information
circBase ID: hsa_circ_0031017
Name: hsa_circ_TMCO3
Synonym: circTMCO3
Host Gene: TMCO3
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0008170
Mondo Name: ovarian cancer
Disease details:
 ovarian cancer
Disease DO ID: 2394
Disease MeSH ID: D010051
Disease NCIt ID: C7431
Disease ICD11 ID: 685124533
Disease OMIM ID: 167000
Species: Homo sapiens
Sample Source: patient tissue
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: TAMs
Detected method:
primary cell isolation + qRT-PCR
Description:

hsa_circ_0031017 / circTMCO3 was upregulated in tumor-associated macrophages isolated from ovarian cancer tissues compared with normal tissue macrophages. M2 macrophage-derived exosomal circTMCO3 promoted ovarian cancer cell proliferation, migration, and invasion through the miR-515-5p/ITGA8 axis.
Other information
Title:

M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer.

Journal: Communications biology
Published: 2024
PubMed ID: 38755265
Data availability: -