circRNA basic information
circBase ID: -
Name: hsa_circ_PLEKHM1
Synonym: circPLEKHM1
Host Gene: PLEKHM1
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0008903
Mondo Name: lung cancer
Disease details:
 lung cancer
Disease DO ID: 1324
Disease MeSH ID: -
Disease NCIt ID: C7377
Disease ICD11 ID: -
Disease OMIM ID: 211980
Species: Homo sapiens
Sample Source: animal tissue
circRNA-celltype information
Expression pattern:
UP
Cell type: macrophage
Cell type details: tumor‐infiltrated M2 macrophages
Detected method:
primary cell isolation + qRT-PCR
Description:

circPLEKHM1 expression was higher in tumor-infiltrated M2 macrophages than in M1 macrophages isolated from lung cancer metastases in a mouse model. The study links this circPLEKHM1/PABPC1/eIF4G complex to OSMR translation and M2 macrophage polarization during lung cancer metastasis.
Other information
Title:

Hypoxic Exosomal circPLEKHM1-Mediated Crosstalk between Tumor Cells and Macrophages Drives Lung Cancer Metastasis.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published: 2024
PubMed ID: 38509870
Data availability: -