circRNA basic information
circBase ID: hsa_circ_0034880
Name: -
Synonym: -
Host Gene: -
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005575
Mondo Name: colorectal cancer
Disease details:
 colorectal cancer
Disease DO ID: 5672, 9256
Disease MeSH ID: -
Disease NCIt ID: C4978
Disease ICD11 ID: -
Disease OMIM ID: 114500
Species: Homo sapiens
Sample Source: patient tissue
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: CD206+ pro-tumor TAMs
Detected method:
cell-type co-localization
Description:

FISH for circ-0034880 combined with immunofluorescence staining of TAM markers CD86 and CD206 supported circ-0034880 detection in TAMs from clinical CRC primary and liver metastatic lesions. Higher circ-0034880 in CRC liver metastatic lesions correlated positively with CD206+ pro-tumor TAM infiltration.
Other information
Title:

Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1highCD206+ pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis.

Journal: Molecular cancer
Published: 2024
PubMed ID: 39164758
Data availability: -