circRNA basic information
circBase ID: mmu_circ_0001477
Name: mmu_circ_Fam190a
Synonym: circFam190a
Host Gene: Fam190a
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005298
Mondo Name: osteoporosis
Disease details:
 osteoporosis
Disease DO ID: 11476
Disease MeSH ID: D010024
Disease NCIt ID: C3298
Disease ICD11 ID: 2113001430
Disease OMIM ID: 166710
Species: Mus musculus
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
UP
Cell type: other
Cell type details: osteoclasts
Detected method:
primary cell isolation + RNA-seq; primary cell isolation + qRT-PCR
Description:

circFam190a was identified by circRNA-seq of primary mouse BMM-derived osteoclast differentiation stages and validated by qPCR as up-regulated in mature osteoclasts. Functional assays showed circFam190a promotes osteoclast differentiation and bone resorption.
Other information
Title:

CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex.

Journal: Experimental & molecular medicine
Published: 2023
PubMed ID: 37653038
Data availability: CRA009230