circRNA basic information
circBase ID: hsa_circ_0054243
Name: hsa_circ_EML4
Synonym: -
Host Gene: EML4
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005233
Mondo Name: non-small cell lung carcinoma
Disease details:
 non-small cell lung cancer / NSCLC
Disease DO ID: 3908
Disease MeSH ID: D002289
Disease NCIt ID: C2926
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: patient tissue
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: M2‐TAMs
Detected method:
cell-type co-localization
Description:

FISH with CD163 labeling showed increased circEML4-positive M2 tumor-associated macrophages in NSCLC tissues from smoking patients compared with non-smoking patients. The study links circEML4 in EVs from M2-TAMs to promotion of NSCLC progression through the SOCS2/JAK-STAT signaling axis.
Other information
Title:

Smoking-Induced M2-TAMs, via circEML4 in EVs, Promote the Progression of NSCLC through ALKBH5-Regulated m6A Modification of SOCS2 in NSCLC Cells.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published: 2023
PubMed ID: 37246269
Data availability: -