circRNA basic information
circBase ID: mmu_circ_0001468
Name: mmu_circ_HIPK2
Synonym: -
Host Gene: HIPK2
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005156
Mondo Name: encephalomyelitis
Disease details:
 central nervous system inflammation
Disease DO ID: 640
Disease MeSH ID: D004679
Disease NCIt ID: C34580
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Mus musculus
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
DN
Cell type: astrocyte
Cell type details: primary astrocytes
Detected method:
primary cell isolation + qRT-PCR
Description:

In LPS-treated active primary mouse astrocytes, rapamycin treatment decreased circHIPK2 expression compared with LPS alone. The authors link this decrease to suppression of astrocytic inflammation through the circHIPK2-SIGMAR1 axis.
Other information
Title:

Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1.

Journal: International immunopharmacology
Published: 2023
PubMed ID: 36827915
Data availability: -