circRNA basic information
circBase ID: mmu_circ_0001468
Name: mmu_circ_HIPK2
Synonym: -
Host Gene: HIPK2
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005156
Mondo Name: encephalomyelitis
Disease details:
 central nervous system inflammation
Disease DO ID: 640
Disease MeSH ID: D004679
Disease NCIt ID: C34580
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Mus musculus
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
UP
Cell type: astrocyte
Cell type details: primary astrocytes
Detected method:
primary cell isolation + qRT-PCR
Description:

In primary mouse astrocytes, LPS treatment increased circHIPK2 expression compared with untreated control cells. Knockdown of circHIPK2 suppressed inflammatory markers in LPS-treated primary astrocytes.
Other information
Title:

Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1.

Journal: International immunopharmacology
Published: 2023
PubMed ID: 36827915
Data availability: -