circRNA basic information
circBase ID: mmu_circ_0002047
Name: mmu_circ_B4galnt1
Synonym: cir2047
Host Gene: B4galnt1
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0012511
Mondo Name: preterm premature rupture of the membranes
Disease details:
 premature rupture of membranes
Disease DO ID: 0111144
Disease MeSH ID: C563032
Disease NCIt ID: C92862
Disease ICD11 ID: -
Disease OMIM ID: 610504
Species: Mus musculus
Sample Source: animal tissue
circRNA-celltype information
Expression pattern:
UP
Cell type: macrophage
Cell type details: F4/80-positive cells
Detected method:
cell sorting + qRT-PCR; cell-type co-localization
Description:

Cir2047/mmu_circ_0002047 was elevated in F4/80-positive macrophages after LPS-induced PROM modeling and was co-expressed with F4/80 in uterine macrophages by in situ hybridization and immunostaining. Functional experiments in F4/80-positive macrophages indicated that cir2047 maintains M1 polarization and MMP secretion through the miR-1931/TRAF6/NF-κB pathway.
Other information
Title:

Uterine macrophages as treatment targets for therapy of premature rupture of membranes by modified ADSC-EVs through a circRNA/miRNA/NF-κB pathway.

Journal: Journal of nanobiotechnology
Published: 2022
PubMed ID: 36402996
Data availability: -