circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: hsa_circ_000284
Host Gene: HIPK3
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005178
Mondo Name: osteoarthritis
Disease details:
 Osteoarthritis
Disease DO ID: 8398
Disease MeSH ID: D010003
Disease NCIt ID: C3293
Disease ICD11 ID: 558562409
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
DN
Cell type: chondrocyte
Cell type details: HC‐a chondrocytes
Detected method:
primary cell isolation + qRT-PCR
Description:

In human primary HC‐a chondrocytes, IL‐1β stimulation decreased circHIPK3 expression by RT-qPCR. Functional experiments in the same chondrocyte system showed circHIPK3 regulated ROS production and mitochondria-mediated apoptosis.
Other information
Title:

CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR-30a-3p and promoting PON2.

Journal: Cell proliferation
Published: 2022
PubMed ID: 35716032
Data availability: -