circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0008383
Mondo Name: rheumatoid arthritis
Disease details:
 rheumatoid arthritis
Disease DO ID: 7148
Disease MeSH ID: D001172
Disease NCIt ID: C2884
Disease ICD11 ID: 576319925
Disease OMIM ID: 180300
Species: Homo sapiens
Sample Source: primary cell culture
circRNA-celltype information
Expression pattern:
DN
Cell type: fibroblast
Cell type details: RA-FLS
Detected method:
primary cell isolation + qRT-PCR
Description:

ATO treatment down-regulated circHIPK3 in RA-FLS, with a stronger decrease under TNF-α induction. The study linked this suppression to reduced FOXO1/VEGF expression and antiangiogenic effects in RA-FLS.
Other information
Title:

Angiogenesis is Inhibited by Arsenic Trioxide Through Downregulation of the CircHIPK3/miR-149-5p/FOXO1/VEGF Functional Module in Rheumatoid Arthritis.

Journal: Frontiers in pharmacology
Published: 2021
PubMed ID: 34776969
Data availability: -