title circrna_id circ_rna_name circrna_synonyms disease_do_id disease_do_name disease_details method expression_pattern description support_count Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. - hsa_circ_ANRIL - DOID:1936 atherosclerosis atherosclerosis RNA-seq down-regulated "ANRIL encodes a heterogeneous species of rare RNA transcripts. Moreover, we identified novel, circular ANRIL isoforms (cANRIL) whose expression correlated with INK4/ARF transcription and ASVD risk." 4 Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. - hsa_circ_ANRIL - DOID:1936 atherosclerosis atherosclerosis RNA-seq down-regulated "ANRIL encodes a heterogeneous species of rare RNA transcripts. Moreover, we identified novel, circular ANRIL isoforms (cANRIL) whose expression correlated with INK4/ARF transcription and ASVD risk." 4 "Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues." hsa_circ_0024169 hsa_circ_CUL5 circ0817 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation. 1 "Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues." hsa_circ_0002138 hsa_circ_USP3 circ3204 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation. 2 "Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues." hsa_circ_0000523 hsa_circ_METTL3 circ6229 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation. 4 "Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues." - hsa_circ_TNS4 circ7374 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation. 1 "Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues." - - circ7780 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation. 1 Using circular RNA as a novel type of biomarker in the screening of gastric cancer. hsa_circ_0000140 hsa_circ_KIAA0907 hsa_circ_002059 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Hsa_circ_0000140 lower expression levels were significantly correlated with distal metastasis, TNM stage, gender and age." 3 Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/beta-catenin pathway. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR down-regulated "ITCH hyper expression promotes ubiquitination and degradation of phosphorylated Dvl2, thereby inhibiting the Wnt/beta-catenin pathway. These results indicate that cir-ITCH may have an inhibitory effect on ESCC by regulating the Wnt pathway." 1 cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/beta-catenin pathway. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Cir-ITCH expression was typically down-regulated in CRC compared to the peritumoral tissue. This result, as well as several follow-up experi- ments, showed that cir-ITCH could increase the level of ITCH, which is involved in the inhibi- tion of the Wnt/beta-catenin pathway." 1 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. - hsa_circ_KLDHC10 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated expression levels of circ-KLDHC10 were significantly increased in cancer serum than those in NS. 1 "The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells." - - mmu_circ_0001878 DOID:9351 diabetes mellitus diabetes RT-qPCR up-regulated "We further identified a new target Myrip in the Cdr1as/miR-7 pathway that regulates insulin granule secretion, and also another target Pax6 that enhances insulin transcription." 1 Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma. hsa_circ_0001649 hsa_circ_SHPRH - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated Hsa_circ_0001649 was significantly downregulated in hepatocellular carcinoma (HCC). Our findings indicate hsa_circ_0001649 might serve as a novel potential biomarker for HCC and may function in tumorigenesis and metastasis of HCC. 4 Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis. - hsa_circ_FOXO3 - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "The breast tumor tissues expressed low levels of circ-Foxo3, Foxo3P and Foxo3 compared with normal tissues. We found that the ectopic expression of the Foxo3P, Foxo3 circular RNA and Foxo3 mRNA could all suppress tumor growth and cancer cell proliferation and survival." 3 Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:0060108 brain glioma glioma RT-qPCR down-regulated The axis miR-671-5p/CDR1-AS/CDR1/VSNL1 is functionally altered in GBM cells and is involved in the modification of their biopathological profile. 2 A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. - - mm9-circ-012559 DOID:6000 congestive heart failure congestive heart failure RT-qPCR down-regulated Heart-related circRNA inhibits cardiomyocytes hypertrophy through targeting miR-223 and apoptosis repressor with CARD domain. 1 Circular RNA expression alterations are involved in OGD/R-induced neuron injury. - - mmu-circRNA-015947 DOID:936 brain disease ischemia reperfusion injury RT-qPCR up-regulated This research suggests that the overlapping expression of mmu-circRNA-015947 might be involved in the process of cerebral IRI and presents a novel molecular target for clinical therapy. 1 Circular RNA in blood corpuscles combined with plasma protein factor for early prediction of pre-eclampsia. - - circ_101222 DOID:10591 pre-eclampsia preeclampsia "RT-qPCR, microarray" up-regulated Plasma protein endoglin in combination with circ_101222 strengthened the predictive power for pre-eclampsia. 1 Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. - mmu_circ_FOXO3 - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated The circular RNA circ-Foxo3 was highly expressed in noncancer cells and were associated with cell cycle progression. Silencing endogenous circ-Foxo3 promoted cell proliferation. 1 Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. - mmu_circ_FOXO3 - DOID:1909 melanoma melanoma RT-qPCR down-regulated The circular RNA circ-Foxo3 was highly expressed in noncancer cells and were associated with cell cycle progression. Silencing endogenous circ-Foxo3 promoted cell proliferation. 1 Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. - hsa_circ_FOXO3 - DOID:114 heart disease cardiac senescence RT-qPCR up-regulated We also found that silencing circ-Foxo3 inhibited senescence of mouse embryonic fibroblasts and that ectopic expression of circ-Foxo3 induced senescence. 1 Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. - mmu_circ_FOXO3 - DOID:114 heart disease cardiac senescence RT-qPCR up-regulated We also found that silencing circ-Foxo3 inhibited senescence of mouse embryonic fibroblasts and that ectopic expression of circ-Foxo3 induced senescence. 2 Circular RNA profile in gliomas revealed by identification tool UROBORUS. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:0060108 brain glioma glioma RNA-seq down-regulated "There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function." 2 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_ATRNL1 - DOID:0060108 brain glioma glioma RNA-seq down-regulated "There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function." 1 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_AKT3 - DOID:0060108 brain glioma glioma RNA-seq down-regulated "There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function." 1 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_SPTAN1 - DOID:0060108 brain glioma glioma RNA-seq down-regulated "There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function." 1 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_ZNF483 - DOID:0060108 brain glioma glioma RNA-seq down-regulated "There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function." 1 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_RIMS1 - DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" down-regulated "There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function." 1 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_FKBP8 - DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" down-regulated "There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function." 2 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_UNC13C - DOID:0060108 brain glioma glioma RNA-seq down-regulated "There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function." 1 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_COL1A2 - DOID:0060108 brain glioma glioma RNA-seq up-regulated "There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM." 1 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_PTN - DOID:0060108 brain glioma glioma RNA-seq up-regulated "There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM." 3 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_VCAN - DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" up-regulated "There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM." 3 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_SMO - DOID:0060108 brain glioma glioma RNA-seq up-regulated "There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM." 1 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_PLOD2 - DOID:0060108 brain glioma glioma RNA-seq up-regulated "There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM." 1 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_GLIS3 - DOID:0060108 brain glioma glioma RNA-seq up-regulated "There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM." 2 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_EPHB4 - DOID:0060108 brain glioma glioma RNA-seq up-regulated "There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM." 3 Circular RNA profile in gliomas revealed by identification tool UROBORUS. - hsa_circ_CLIP2 - DOID:0060108 brain glioma glioma RNA-seq up-regulated "There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM." 3 Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances. hsa_circ_0001451 hsa_circ_FBXW7 hsa_circ_001988 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated The expression of hsa_circ_001988 was signi cantly correlated with differentiation and perineural invasion. 3 Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 Sponge in Human Cartilage Degradation. hsa_circ_0023404 hsa_circ_CER circRNA_100876 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" up-regulated We demonstrated that circRNA-CER regulated MMP13 expression and participated in the process of chondrocyte ECM degradation. 1 The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated "Cdr1as also functioned as a powerful miR-7a sponge in myocardial cells, and showed regulation on the protective role of miR-7a in myocardial infarction (MI) injury, involving the function of miR-7a targets, PARP and SP1." 1 Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations. - - f-circRNA DOID:1240 leukemia leukemia "RT-qPCR, RNA-seq" up-regulated "F-circRNAs contribute to cellular transformation, promote cell viability and resistance upon therapy, and have tumor-promoting properties in in_ivo models. Our work expands the current knowledge regarding molecular mechanisms involved in cancer onset and progression, with potential diagnostic and therapeutic implications." 1 Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "A subsequent cell proliferation assay indicated that the downregulation of circHIPK3, but not HIPK3 mRNA, significantly suppressed cell growth in different cell types. Consistent with this result from the siRNA knockdown experiments, we observed that cell proliferation was significantly suppressed on the knockdown of circHIPK3 expression in HEK-293T cells via CRISPR/Cas9 technology." 6 Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. hsa_circ_0000677 hsa_circ_ABCC1 circRNA_001569 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated hsa_circ_001569 acted as a positive regulator in cell proliferation and invasion of colorectal cancer. 2 Circular RNA expression in basal cell carcinoma. hsa_circ_0075828 hsa_circ_LINC00340 hsa_circRNA_104083 DOID:2513 basal cell carcinoma basal cell carcinoma microarray up-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 3 Circular RNA expression in basal cell carcinoma. hsa_circ_0075825 hsa_circ_LINC00340 hsa_circRNA_104081 DOID:2513 basal cell carcinoma basal cell carcinoma microarray up-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 3 Circular RNA expression in basal cell carcinoma. hsa_circ_0008732 hsa_circ_BNC2 hsa_circRNA_104738 DOID:2513 basal cell carcinoma basal cell carcinoma "RT-qPCR, microarray" up-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 2 Circular RNA expression in basal cell carcinoma. hsa_circ_0075829 hsa_circ_LINC00340 hsa_circRNA_104084 DOID:2513 basal cell carcinoma basal cell carcinoma "RT-qPCR, microarray" up-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 3 Circular RNA expression in basal cell carcinoma. hsa_circ_0001370 hsa_circ_YEATS2 hsa_circRNA_001830 DOID:2513 basal cell carcinoma basal cell carcinoma microarray up-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 1 Circular RNA expression in basal cell carcinoma. hsa_circ_0005795 hsa_circ_LPXN hsa_circRNA_100823 DOID:2513 basal cell carcinoma basal cell carcinoma microarray up-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 2 Circular RNA expression in basal cell carcinoma. hsa_circ_0004777 hsa_circ_SOX13 hsa_circRNA_100432 DOID:2513 basal cell carcinoma basal cell carcinoma microarray up-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 1 Circular RNA expression in basal cell carcinoma. hsa_circ_0080189 hsa_circ_TNS3 hsa_circRNA_104370 DOID:2513 basal cell carcinoma basal cell carcinoma microarray up-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 1 Circular RNA expression in basal cell carcinoma. hsa_circ_0086419 hsa_circ_BNC2 hsa_circRNA_104739 DOID:2513 basal cell carcinoma basal cell carcinoma microarray up-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 2 Circular RNA expression in basal cell carcinoma. hsa_circ_0005912 hsa_circ_FIP1L1 hsa_circRNA_103643 DOID:2513 basal cell carcinoma basal cell carcinoma "RT-qPCR, microarray" up-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 1 Circular RNA expression in basal cell carcinoma. hsa_circ_0022383 hsa_circ_FADS2 hsa_circRNA_100833 DOID:2513 basal cell carcinoma basal cell carcinoma microarray down-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 2 Circular RNA expression in basal cell carcinoma. hsa_circ_0022392 hsa_circ_FADS2 hsa_circRNA_100834 DOID:2513 basal cell carcinoma basal cell carcinoma microarray down-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 2 Circular RNA expression in basal cell carcinoma. hsa_circ_0005085 hsa_circ_ASAP2 hsa_circRNA_102612 DOID:2513 basal cell carcinoma basal cell carcinoma microarray down-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 1 Circular RNA expression in basal cell carcinoma. hsa_circ_0015449 hsa_circ_SOAT1 hsa_circRNA_100410 DOID:2513 basal cell carcinoma basal cell carcinoma microarray down-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 1 Circular RNA expression in basal cell carcinoma. hsa_circ_0072387 hsa_circ_HMGCS1 hsa_circRNA_103829 DOID:2513 basal cell carcinoma basal cell carcinoma microarray down-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 1 Circular RNA expression in basal cell carcinoma. hsa_circ_0046449 hsa_circ_TBCD hsa_circRNA_102246 DOID:2513 basal cell carcinoma basal cell carcinoma microarray down-regulated We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC. 1 Circular RNA: a novel biomarker for progressive laryngeal cancer. - - hsa_circRNA_100855 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "The hsa_circRNA_100855 level was signicantly higher in laryngeal squamous cell cancer (LSCC) than in the corresponding adjacent non-neoplastic tissues. Patients with T3-4 stage, neck nodal metastasis or advanced clinical stage had higher hsa_circRNA_100855 expression." 1 Circular RNA: a novel biomarker for progressive laryngeal cancer. - - hsa_circRNA_104912 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma "RT-qPCR, microarray" down-regulated "The hsa_circRNA_104912 level was signicantly lower in laryngeal squamous cell cancer (LSCC) than in corresponding adjacent non-neoplastic tissues. Patients with T3-4 stage, neck nodal metastasis, poor differentiation or advanced clinical stage had a lower hsa_circRNA_104912 expression. Overall, our data suggest that circRNAs play an important role in the tumorigenesis of LSCC and may serve as novel and stable biomarkers for the diagnosis and progress of LSCC." 1 "Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development." hsa_circ_0005075 hsa_circ_EIF4G3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Hsa_circ_0005075 expression shows significant association with some clinicopathological factors of hepatocellular carcinoma (HCC) patients, and may serve as a novel potential biomarker for HCC diagnosis." 4 Circular RNA expression in cutaneous squamous cell carcinoma. hsa_circ_0022383 hsa_circ_FADS2 hsa_circRNA_100833 DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma "RT-qPCR, microarray" down-regulated "Regarding the top down-regulated circRNAs, hsa_circ_0022392 and hsa_circ_0022383 are both spliced from Fatty Acid Desaturase 2 (FADS2), which is localized at the cancer genomic hotspot 11q13 locus and codes for an enzyme with ?_6 and ?_8-desaturase activity necessary for normal eicosanoid precursor synthesis previously shown in human breast 19 cancer cells." 3 Circular RNA expression in cutaneous squamous cell carcinoma. hsa_circ_0022392 hsa_circ_FADS2 hsa_circRNA_100834 DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma "RT-qPCR, microarray" down-regulated "Regarding the top down-regulated circRNAs, hsa_circ_0022392 and hsa_circ_0022383 are both spliced from Fatty Acid Desaturase 2 (FADS2), which is localized at the cancer genomic hotspot 11q13 locus and codes for an enzyme with ?_6 and ?_8-desaturase activity necessary for normal eicosanoid precursor synthesis previously shown in human breast 19 cancer cells." 3 Circular RNA expression in cutaneous squamous cell carcinoma. hsa_circ_0070933 hsa_circ_LARP1B hsa_circRNA_103736 DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma "RT-qPCR, microarray" up-regulated "Both of the two most up-regulated circRNAs in this study, hsa_circ_0070933 and 18 hsa_circ_0070934, are spliced from La Ribonucleoprotein Domain Family, Member 1B (LARP1B)." 5 Circular RNA expression in cutaneous squamous cell carcinoma. hsa_circ_0070934 hsa_circ_LARP1B hsa_circRNA_103737 DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma "RT-qPCR, microarray" up-regulated "Both of the two most up-regulated circRNAs in this study, hsa_circ_0070933 and 18 hsa_circ_0070934, are spliced from La Ribonucleoprotein Domain Family, Member 1B (LARP1B)." 5 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_CDR1as DOID:114 heart disease heart failure "RT-qPCR, microarray" up-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_004775 DOID:114 heart disease heart failure "RT-qPCR, microarray" up-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_007687 DOID:114 heart disease heart failure "RT-qPCR, microarray" up-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_013216 DOID:114 heart disease heart failure "RT-qPCR, microarray" up-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_010567 DOID:114 heart disease heart failure "RT-qPCR, microarray" up-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_015506 DOID:114 heart disease heart failure "RT-qPCR, microarray" up-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_001135 DOID:114 heart disease heart failure "RT-qPCR, microarray" down-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_002007 DOID:114 heart disease heart failure "RT-qPCR, microarray" down-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_004768 DOID:114 heart disease heart failure "RT-qPCR, microarray" down-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_008398 DOID:114 heart disease heart failure "RT-qPCR, microarray" down-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_008640 DOID:114 heart disease heart failure "RT-qPCR, microarray" down-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure. - - mmu_circRNA_014961 DOID:114 heart disease heart failure "RT-qPCR, microarray" down-regulated The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. 1 Comprehensive analysis of differentially expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in bladder carcinoma. - hsa_circ_MYLK - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "LncRNA-H19 and circular MYLK as well as circular CTDP1 could regulate the expression of DNMT3B, HAS3, VEGFA and ITGB1 through competing miRNA response elements (MREs) of miRNA-29a-3p, which would result in growth and metastasis of cancer." 3 Comprehensive analysis of differentially expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in bladder carcinoma. - hsa_circ_CTDP1 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "LncRNA-H19 and circular MYLK as well as circular CTDP1 could regulate the expression of DNMT3B, HAS3, VEGFA and ITGB1 through competing miRNA response elements (MREs) of miRNA-29a-3p, which would result in growth and metastasis of cancer." 1 The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Knockdown of Cdr1as suppressed the expression of miR-7 and also inhibited the CCNE1 and PIK3CD expression. Furthermore, knockdown of Cdr1as suppressed the HCC cell proliferation and invasion through targeting miR-7." 4 hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder. hsa_circ_0001410 hsa_circ_DCUN1D4 hsa_circRNA_103636 DOID:1470 major depressive disorder major depressive disorder "RT-qPCR, microarray" down-regulated These results suggest that altered expression of hsa_circRNA_103636 in peripheral blood mononuclear cells (PBMCs) is a potential novel biomarker for the diagnosis and treatment of major depressive disorder (MDD). 1 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. hsa_circ_0089974 hsa_circ_NHS circRNA_104983 DOID:1107 esophageal carcinoma radioresistant esophageal cancer cells "RT-qPCR, microarray" up-regulated "To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance." 1 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. hsa_circ_0000554 hsa_circ_LIN52 circRNA_001059 DOID:1107 esophageal carcinoma radioresistant esophageal cancer cells "RT-qPCR, microarray" up-regulated "To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance." 1 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. hsa_circ_0002019 hsa_circ_FOXRED1 circRNA_100984 DOID:1107 esophageal carcinoma radioresistant esophageal cancer cells "RT-qPCR, microarray" up-regulated "To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance." 1 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. hsa_circ_0014879 hsa_circ_DCAF8 circRNA_100367 DOID:1107 esophageal carcinoma radioresistant esophageal cancer cells "RT-qPCR, microarray" up-regulated "To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance." 1 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. hsa_circ_0004519 hsa_circ_RFWD3 circRNA_101877 DOID:1107 esophageal carcinoma radioresistant esophageal cancer cells "RT-qPCR, microarray" down-regulated "To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance." 1 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. hsa_circ_0058058 hsa_circ_ATIC circRNA_102913 DOID:1107 esophageal carcinoma radioresistant esophageal cancer cells "RT-qPCR, microarray" down-regulated "To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance." 2 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. hsa_circ_0001336 hsa_circ_EEFSEC circRNA_000695 DOID:1107 esophageal carcinoma radioresistant esophageal cancer cells "RT-qPCR, microarray" down-regulated "To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance." 1 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. hsa_circ_0000518 hsa_circ_RPPH1 circRNA_000167 DOID:1107 esophageal carcinoma radioresistant esophageal cancer cells "RT-qPCR, microarray" down-regulated "To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance." 1 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. hsa_circ_0032832 hsa_circ_STON2 circRNA_101419 DOID:1107 esophageal carcinoma radioresistant esophageal cancer cells "RT-qPCR, microarray" down-regulated "To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance." 1 Characterization of circular RNAs landscape in multiple system atrophy brain. hsa_circ_0038374 hsa_circ_IQCK - DOID:4752 multiple system atrophy multiple system atrophy RT-qPCR up-regulated "Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP1, were identified and validated as specifically over-expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts. " 1 Characterization of circular RNAs landscape in multiple system atrophy brain. hsa_circ_0054211 hsa_circ_MAP4K3 - DOID:4752 multiple system atrophy multiple system atrophy RT-qPCR up-regulated "Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP2, were identified and validated as specifically over-expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts." 1 Characterization of circular RNAs landscape in multiple system atrophy brain. hsa_circ_0032891 hsa_circ_EFCAB11 - DOID:4752 multiple system atrophy multiple system atrophy RT-qPCR up-regulated "Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP3, were identified and validated as specifically over-expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts." 1 Characterization of circular RNAs landscape in multiple system atrophy brain. hsa_circ_0108308 hsa_circ_DTNA - DOID:4752 multiple system atrophy multiple system atrophy RT-qPCR up-regulated "Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP4, were identified and validated as specifically over-expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts." 1 Characterization of circular RNAs landscape in multiple system atrophy brain. hsa_circ_0005540 hsa_circ_MCTP1 - DOID:4752 multiple system atrophy multiple system atrophy RT-qPCR up-regulated "Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP5, were identified and validated as specifically over-expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts." 1 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. hsa_circ_0041103 hsa_circ_TCF25 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "Over-expression of circTCF25 could down-regulate miR-103a-3p and miR-107, increase CDK6 expression, and promote proliferation and migration in vitro and vivo." 1 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. hsa_circ_0072088 hsa_circ_ZFR - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "Total of 469 dysregulated circular transcripts are found in bladder cancer compared with normal tissues, among which 285 were up-regulated and 184 were down-regulated. Six circRNAs were identified to have significant differences by qRT-PCR." 3 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. hsa_circ_0005273 hsa_circ_PTK2 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "Total of 469 dysregulated circular transcripts are found in bladder cancer compared with normal tissues, among which 285 were up-regulated and 184 were down-regulated. Six circRNAs were identified to have significant differences by qRT-PCR." 4 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. hsa_circ_0061265 hsa_circ_BC048201 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "Total of 469 dysregulated circular transcripts are found in bladder cancer compared with normal tissues, among which 285 were up-regulated and 184 were down-regulated. Six circRNAs were identified to have significant differences by qRT-PCR." 2 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. hsa_circ_0007158 hsa_circ_FAM169A - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" down-regulated "Total of 469 dysregulated circular transcripts are found in bladder cancer compared with normal tissues, among which 285 were up-regulated and 184 were down-regulated. Six circRNAs were identified to have significant differences by qRT-PCR." 1 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. hsa_circ_0082582 hsa_circ_TRIM24 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" down-regulated "Total of 469 dysregulated circular transcripts are found in bladder cancer compared with normal tissues, among which 285 were up-regulated and 184 were down-regulated. Six circRNAs were identified to have significant differences by qRT-PCR." 1 RBM20 Regulates Circular RNA Production From the Titin Gene. - - cTtns DOID:12930 dilated cardiomyopathy dilated cardiomyopathy "RT-qPCR, RNA-seq" down-regulated "RBM20 is crucial for the formation of a subset of circRNAs that originate from the I-band of the titin gene. RBM20, by excluding specific exons from the pre-mRNA, provides the substrate to form this class of RBM20-dependent circRNAs." 1 RBM20 Regulates Circular RNA Production From the Titin Gene. - - cTtns DOID:12930 dilated cardiomyopathy dilated cardiomyopathy "RT-qPCR, RNA-seq" down-regulated We show in a patient with an RBM20 mutation and in Rbm20 knockout mice that RBM20 function is required for the production of circRNAs from the I-band region of titin. This suggests that loss of RBM20 may induce myocardial disease not only by abnormal splicing of linear transcripts but possibly also by loss of a specific class of conserved and regulated circRNAs. 1 Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. - hsa_circ_ANRIL - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "CircANRIL induces nucleolar stress and p53 activation, resulting in the induction of apoptosis and inhibition of proliferation, which are key cell functions in atherosclerosis." 4 Landscape of RNAs in human lumbar disc degeneration. hsa_circ_0040039 hsa_circ_SNTB2 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" up-regulated "To validate the circRNAs microarray result, two circRNAs were selected for qRT-PCR validation. The expression of has-circRNA-101852 (P < 0.05) was significantly increased in degenerative samples compared with control whereas the expression of has-circRNA-101645 (P < 0.05) was significantly decreased." 1 Landscape of RNAs in human lumbar disc degeneration. hsa_circ_0036763 hsa_circ_SEMA4B - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated "To validate the circRNAs microarray result, two circRNAs were selected for qRT-PCR validation. The expression of has-circRNA-101852 (P < 0.05) was significantly increased in degenerative samples compared with control whereas the expression of has-circRNA-101645 (P < 0.05) was significantly decreased." 2 "A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis." - mmu_circ_Rar1 - DOID:3602 toxic encephalopathy lead-induced neuronal cell apoptosis RNA-seq up-regulated lncRpa and circRar1 induced the upregulation of apoptosis-associated factors caspase8 and p38 at the mRNA and protein levels via modulation of their common target microRNA miR-671. 1 Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia. - - hsa_circRNA_100782 DOID:10591 pre-eclampsia preeclampsia "RT-qPCR, microarray" up-regulated "The expression levels of hsa_circRNA_100782 (p < 0.05), hsa_circRNA_102682 (p < 0.05), and hsa_circRNA_104820 (p < 0.0001) were validated as significantly up-regulated in the experimental group compared with the controls." 1 Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia. - - hsa_circRNA_102682 DOID:10591 pre-eclampsia preeclampsia "RT-qPCR, microarray" up-regulated "The expression levels of hsa_circRNA_100782 (p < 0.05), hsa_circRNA_102682 (p < 0.05), and hsa_circRNA_104820 (p < 0.0001) were validated as significantly up-regulated in the experimental group compared with the controls." 1 Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia. - - hsa_circRNA_104820 DOID:10591 pre-eclampsia preeclampsia "RT-qPCR, microarray" up-regulated "The expression levels of hsa_circRNA_100782 (p < 0.05), hsa_circRNA_102682 (p < 0.05), and hsa_circRNA_104820 (p < 0.0001) were validated as significantly up-regulated in the experimental group compared with the controls." 1 Myocardial Infarction-Associated Circular RNA Predicting Left Ventricular Dysfunction. - - MICRA DOID:5844 myocardial infarction myocardial Infarction RT-qPCR down-regulated "we identified a circRNA, MICRA, whose expression levels measured at reperfusion in peripheral blood samples of patients with acute MI predicted LV dysfunction after 3 to 4 months." 2 Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/beta-catenin signaling pathway. - hsa_circ_ZNF292 cZNF292 DOID:0060108 brain glioma glioma RT-qPCR down-regulated cZNF292 silencing suppresses tube formation by inhibiting glioma cell proliferation and cell cycle progression. 1 The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "The expression levels of ciRS-7 were comparable between HCC and matched non-tumor tissues. However, the highly ciRS-7 expression in HCC tissues was significantly correlated with hepatic MVI, AFP level and younger age and thus partly related with the deterioration of HCC. Especially, ciRS-7 was one of the independent factors of hepatic MVI." 4 Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/beta-Catenin Pathway. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/beta-catenin signaling. cir-ITCH may play an inhibitory role in lung cancer progression by enhancing its parental gene, ITCH, expression." 1 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. - - mm9_circ_013935 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" up-regulated CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH. 1 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. - - mm9_circ_002319 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" up-regulated CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH. 1 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. - - mm9_circ_016983 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" up-regulated CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH. 1 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. - - mm9_circ_009295 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" up-regulated CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH. 1 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. - - mm9_circ_017649 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" up-regulated CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH. 1 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. - - mm9_circ_011775 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" down-regulated CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH. 1 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. - - mm9_circ_011174 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" down-regulated CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH. 1 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. - - mm9_circ_006982 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" down-regulated CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH. 1 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. - - mm9_circ_010484 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" down-regulated CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH. 1 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. - - mm9_circ_011235 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" down-regulated CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH. 1 The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression. - mmu_circ_FOXO3 - DOID:114 heart disease cardiac fibrosis RT-qPCR up-regulated "In this study, mice injected with the chemotherapeutic agent Doxorubicin (Dox) for induction of cardiomyopathy were analyzed for RNA expression levels. Mice with reduced cardiac function had increased expression of circ-Foxo3." 2 Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation. hsa_circ_0067934 hsa_circ_PRKCI - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated The in vitro silence of hsa_circ_0067934 by siRNA inhibited the proliferation and migration of esophageal squamous cell carcinoma (ESCC) cells and blocked cell cycle progression. 2 Circular RNAs and their associations with breast cancer subtypes. - - MCF7_circ_000595 DOID:1612 breast cancer breast cancer RNA-seq up-regulated "This circRNA was found at chr14:102,466,325_102,500,789 and had 12 supporting junction-spanning reads. This circRNA was a spliced product of gene DYNC1H1 and spanned from exons 17 to 56 of the gene. Considering that the exon-intron structure remains intact, the size of this circRNA is about 7 kb and may play a role in post-transcriptional regulation. Notably, the circRNA contained microRNA response elements (MRE) for miR-150 and miR-661 with 29 and 23 unique binding sites respectively. These two microRNAs have been previously reported to have associations with cancer." 1 Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus. hsa_circ_0054633 hsa_circ_PNPT1 - DOID:9352 type 2 diabetes mellitus type 2 diabetes mellitus "RT-qPCR, microarray" up-regulated Hsa_circ_0054633 presented a certain diagnostic capability for pre-diabetes and T2DM. 3 Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity. - hsa_circ_FOXO3 - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "silencing endogenous circ-Foxo3 enhanced cell viability, whereas ectopic expression of circ-Foxo3 triggered stress-induced apoptosis and inhibited the growth of tumor xenografts." 3 Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. - hsa_circ_FAT1 - DOID:219 colon cancer colon cancer "RT-qPCR, RNA-seq" down-regulated CircFAT1 was significantly down-regulated in the mutant_RAS_ell line (HCT116). 1 Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. - hsa_circ_ARHGAP5 - DOID:219 colon cancer colon cancer "RT-qPCR, RNA-seq" down-regulated two of three significantly regulated circRNAs between_RAS_utant and WT exosomes were down-regulated in_RAS_utant (circFAT1 and circARHGAP5). 1 Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung disease. hsa_circ_0000615 hsa_circ_ZNF609 - DOID:10487 Hirschsprung disease hirschsprung disease RT-qPCR down-regulated Cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p. 1 Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1. - hsa_circ_PVT1 - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated "Our findings indicate that the SAC-RNA CircPVT1, elevated in dividing cells and reduced in senescent cells, sequesters let-7 to enable a proliferative phenotype." 3 Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1. - hsa_circ_PVT1 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated "Our findings indicate that the SAC-RNA CircPVT1, elevated in dividing cells and reduced in senescent cells, sequesters let-7 to enable a proliferative phenotype." 4 Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. - hsa_circ_PVT1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated CircPVT1 may promote cell proliferation by acting as a sponge for members of the miR-125 family. The level of circPVT1 was observed as an independent prognostic marker for overall survival and disease-free survival of patients with GC. 6 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" up-regulated "To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data." 1 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. hsa_circ_0005397 hsa_circ_RHOT1 - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" up-regulated "To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data." 1 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. hsa_circ_0006913 hsa_circ_ARID1A - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" down-regulated "To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data." 1 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. hsa_circ_0000257 hsa_circ_NOLC1 - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" down-regulated "To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data." 1 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. hsa_circ_0005785 hsa_circ_ANAPC7 - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" down-regulated "To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data." 1 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. hsa_circ_0041150 hsa_circ_RPH3AL - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" down-regulated "To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data." 1 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. hsa_circ_0008719 hsa_circ_AKT2 - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" down-regulated "To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data." 1 "Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer." hsa_circ_0000069 hsa_circ_STIL - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "By using specically designed siRNAs in colorectal cancer (CRC) cells, a functional analysis was performed which revealed that hsa_circ_0000069 knockdown could notably inhibit cell prolif- eration, migration, and invasion, and induce G0/G1 phase arrest of cell cycle in vitro." 4 Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease. hsa_circ_0124644 hsa_circ_ROBO2 - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated Hsa_circ_0124644 can be used as a diagnostic biomarker of CAD. 2 Parasite biology: Busting out from the inside. hsa_circ_0082081 hsa_circ_CADPS2 - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated "Hsa_circ_0082081 and hsa_circ_0124644 were moderately correlated with the CADS, hsa_circ_0113854 and hsa-circRNA5974-1 were weakly correlated with the CADS and hsa_circ_0098964 was not correlated with the CADS." 1 Viral infection: Fine tuning HCV replication. hsa_circ_0113854 hsa_circ_ATG4C - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated "Hsa_circ_0082081 and hsa_circ_0124644 were moderately correlated with the CADS, hsa_circ_0113854 and hsa-circRNA5974-1 were weakly correlated with the CADS and hsa_circ_0098964 was not correlated with the CADS." 1 Bacterial physiology: Building a bacterial ribosome. hsa_circ_0098964 hsa_circ_SRGAP1 - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated "Hsa_circ_0082081 and hsa_circ_0124644 were moderately correlated with the CADS, hsa_circ_0113854 and hsa-circRNA5974-1 were weakly correlated with the CADS and hsa_circ_0098964 was not correlated with the CADS." 1 Bacterial physiology: Building a bacterial ribosome. - - hsa-circRNA5974-1 DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated "Hsa_circ_0082081 and hsa_circ_0124644 were moderately correlated with the CADS, hsa_circ_0113854 and hsa-circRNA5974-1 were weakly correlated with the CADS and hsa_circ_0098964 was not correlated with the CADS." 1 "Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis." - - hsa_circRNA_100284 DOID:4159 skin cancer skin cancer microarray up-regulated "Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis. This establishes a previously unknown mechanism between arsenite-induced acceleration of the cell cycle and carcinogenesis." 1 "CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts." - - circRNA_000203 DOID:114 heart disease cardiac fibrosis "RT-qPCR, microarray" up-regulated "Enforced-expression of circRNA_000203 could increase expressions of Col1a2, Col3a1 and ?±-SMA in mouse cardiac fibroblasts. over-expression of circRNA_000203 could eliminate the anti-fibrosis effect of miR-26b-5p in cardiac fibroblasts." 2 Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. hsa_circ_0031288 hsa_circ_PABPN1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN1 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels." 2 Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. hsa_circ_0002343 hsa_circ_B3GALNT2 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN2 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels." 1 Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. hsa_circ_0069399 hsa_circ_ARAP2 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN3 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels." 1 Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. hsa_circ_0007386 hsa_circ_CRIM1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN4 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels." 1 Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. hsa_circ_0008844 hsa_circ_MFSD2A - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN5 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels." 1 Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. hsa_circ_0001212 hsa_circ_GUSBP11 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN6 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels." 1 Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. hsa_circ_0001187 hsa_circ_DOPEY2 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN7 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels." 1 Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. hsa_circ_0007928 hsa_circ_DCUN1D4 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN8 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels." 1 Circular RNA 0000096 affects cell growth and migration in gastric cancer. hsa_circ_0000096 hsa_circ_HIAT1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Hsa_circ_0000096 may be used as a potential novel biomarker for gastric cancer. It affects gastric cancer cell growth and migration by regulating cyclin D1, CDK6, MMP-2 and MMP-9." 3 A landscape of circular RNA expression in the human heart. - hsa_circ_SLC8A1-1 CircSLC8A1-1 DOID:114 heart disease heart disease "RT-qPCR, RNA-seq" up-regulated "Flanking introns of the most abundantly expressed circRNA, circSLC8A1-1, are unusually long (250_618_nt) and are enriched with Alu elements." 1 A landscape of circular RNA expression in the human heart. - mmu_circ_SLC8A1-1 CircSLC8A1-1 DOID:114 heart disease heart disease "RT-qPCR, RNA-seq" up-regulated "Using single molecule RNA-FISH, the cytoplasmic localization of circSlc8a1-1 was established in adult mouse cardiomyocytes." 1 Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals. - hsa_circ_HIAT1 - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR down-regulated "The consequences of AR-suppressed circHIAT1 resulted in deregulating miR-195-5p/29a-3p/29c-3p expression, which increased CDC42 expression to enhance ccRCC cell migration and invasion. Increasing this newly identified signal via circHIAT1 suppressed ARenhanced ccRCC cell migration and invasion. Together, these results suggested that circHIAT1 functioned as a metastatic inhibitor to suppress AR-enhanced ccRCC cell migration and invasion." 1 "Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer." - hsa_circ_BANP - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated Knockdown of circ-BANP with siRNA significantly attenuate the proliferation of CRC cells. 3 Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. hsa_circ_0000190 hsa_circ_CNIH4 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Hsa_circ_0000190 may be a novel non-invasive biomarker for the diagnosis of gastric cancer. 3 Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance. hsa_circ_0001649 hsa_circ_SHPRH - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Our test suggested that hsa_circ_0001649 was significantly downregulated in GC and may become a novel potential biomarker in the diagnosis of GC. 2 Circular RNA ciRS-7-A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Functional assays identified overexpression of ciRS-7 in HCT116 and HT29 cells led to blocking of tumor suppressive effects of miR-7 and resulted in a more aggressive oncogenic phenotype, which was subsequently validated in cell lines and a xenograft animal model." 2 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. - - hsa_circRNA_400071 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. " 1 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. - - hsa_circRNA_000543 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. " 1 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. - - hsa_circRNA_001959 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. " 1 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. - - hsa_circRNA_000792 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. " 1 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. - - hsa_circRNA_400066 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. " 1 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. - - hsa_circRNA_001066 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. " 1 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. - - hsa_circRNA_101308 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery. 1 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. - - hsa_circRNA_104423 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery. 1 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. - - hsa_circRNA_104916 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery. 1 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. - - hsa_circRNA_100269 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery. 2 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. - - hsa_circRNA_400033 DOID:10534 stomach cancer gastric cancer microarray up-regulated We further screened eight indicators related to early recurrence. We subsequently divided the remaining cases into two cohorts. qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort. 1 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. - - hsa_circRNA_001653 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated We further screened eight indicators related to early recurrence. We subsequently divided the remaining cases into two cohorts. qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort. 1 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. - - hsa_circRNA_103781 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated We further screened eight indicators related to early recurrence. We subsequently divided the remaining cases into two cohorts. qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort. 1 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. - - hsa_circRNA_103999 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated We further screened eight indicators related to early recurrence. We subsequently divided the remaining cases into two cohorts. qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort. 1 "ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways." hsa_circ_0001727 hsa_circ_ZKSCAN1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq down-regulated "ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration." 3 TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1beta/Derlin-1 pathway. hsa_circ_0000594 hsa_circ_TTBK2 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Enhanced expression of circ-TTBK2 promoted cell proliferation, migration, and invasion, while inhibited apoptosis." 4 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. hsa_circ_0006460 hsa_circ_BRAF - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 1 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. hsa_circ_0005603 hsa_circ_MAP2K4 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 1 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. hsa_circ_0008345 hsa_circ_PTK2 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 2 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. hsa_circ_0004872 hsa_circ_MAPK1 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 1 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. hsa_circ_0006411 hsa_circ_PIK3R1 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 1 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. hsa_circ_0003586 hsa_circ_NF1 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 2 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. hsa_circ_0002968 hsa_circ_MAPK8 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 1 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. hsa_circ_0000199 hsa_circ_AKT3 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 2 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. - - chr4:103501692-103504114 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 1 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. hsa_circ_0001566 hsa_circ_MAPK9 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 1 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. - - chr18:107887-108499 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" up-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 1 Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis. - - chr19:5761476-5761630 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" up-regulated "The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients." 1 Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. - hsa_circ_CCDC66 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "Gain-of-function and loss-of-function studies in CRC cell-lines demonstrated that circCCDC66 controlled multiple pathological processes, including cell proliferation, migration, invasion, and anchorage-independent growth." 4 The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis. hsa_circ_0106803 hsa_circ_GSDMB GSDMB ecircRNA DOID:2377 multiple sclerosis multiple sclerosis RT-qPCR up-regulated "Both alternative splicing (AS) isoforms and the identified ecircRNA were significantly dysregulated in peripheral blood mononuclear cells of relapsing-remitting multiple sclerosis (MS) patients compared to controls, further supporting the notion that aberrant RNA metabolism is a characteristic feature of the disease." 1 CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a. hsa_circ_0005105 hsa_circ_SEC24A - DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Hsa_circ_0005105 can promote extracellular matrix (ECM) degradation by regulating the expression of miR-26a target NAMPT. 3 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. hsa_circ_0004277 hsa_circ_WDR37 - DOID:1240 leukemia leukemia "RT-qPCR, microarray" down-regulated "A downregulated circRNA, hsa_circ_0004277, was characterized and functionally evaluated in a cohort of 115 human samples, thus offering a potential diagnostic marker and treatment target in acute myeloid leukemia (AML)." 1 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. hsa_circ_0035381 hsa_circ_PIGB - DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, microarray" up-regulated "Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression. qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile." 2 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. hsa_circ_0004136 hsa_circ_KCNQ5 - DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, microarray" up-regulated "Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression. qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile." 2 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. hsa_circ_0058058 hsa_circ_ATIC - DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, microarray" up-regulated "Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression. qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile." 1 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. hsa_circ_0017446 hsa_circ_WDR37 - DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, microarray" down-regulated "Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression. qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile." 1 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. hsa_circ_0049657 hsa_circ_NFIX - DOID:9119 acute myeloid leukemia acute myeloid leukemia microarray up-regulated "Two upregulated circRNAs (hsa_circ_0035381, hsa_circ_0049657) and three downregulated circRNAs (hsa_circ_0001187, hsa_circ_0008078, hsa_circ_0001947) were found within the whole profile. This result showed us a circRNA signature not only presents in AML, but also potentially contributes to AML risk-status evaluation." 2 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. hsa_circ_0001187 hsa_circ_DOPEY2 - DOID:9119 acute myeloid leukemia acute myeloid leukemia microarray down-regulated "Two upregulated circRNAs (hsa_circ_0035381, hsa_circ_0049657) and three downregulated circRNAs (hsa_circ_0001187, hsa_circ_0008078, hsa_circ_0001947) were found within the whole profile. This result showed us a circRNA signature not only presents in AML, but also potentially contributes to AML risk-status evaluation." 3 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. hsa_circ_0008078 hsa_circ_DOPEY2 - DOID:9119 acute myeloid leukemia acute myeloid leukemia microarray down-regulated "Two upregulated circRNAs (hsa_circ_0035381, hsa_circ_0049657) and three downregulated circRNAs (hsa_circ_0001187, hsa_circ_0008078, hsa_circ_0001947) were found within the whole profile. This result showed us a circRNA signature not only presents in AML, but also potentially contributes to AML risk-status evaluation." 3 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. hsa_circ_0001947 hsa_circ_AFF2 - DOID:9119 acute myeloid leukemia acute myeloid leukemia microarray down-regulated "Two upregulated circRNAs (hsa_circ_0035381, hsa_circ_0049657) and three downregulated circRNAs (hsa_circ_0001187, hsa_circ_0008078, hsa_circ_0001947) were found within the whole profile. This result showed us a circRNA signature not only presents in AML, but also potentially contributes to AML risk-status evaluation." 1 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0015278 hsa_circ_KLHL20 hsa_circRNA_100395 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" down-regulated "CircRNA dysregulation may play a role in papillary thyroid carcinoma (PTC) pathogenesis, and several key circRNAs show promise as candidate biomarkers for PTC. The hsa_circRNA_100395/miR-141-3p/ miR-200a-3p axis may be involved in the pathogenesis of PTC." 2 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0021553 hsa_circ_MPPED2 hsa_circRNA_100777 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" down-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 1 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0079891 hsa_circ_ELMO1 hsa_circRNA_104348 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" down-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 1 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0067103 hsa_circ_ZNF148 hsa_circRNA_103454 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" down-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 1 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0004458 hsa_circ_PSD3 hsa_circRNA_104566 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 5 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0002111 hsa_circ_PSD3 hsa_circRNA_104565 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 5 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0008016 hsa_circ_FGFR1 hsa_circRNA_104595 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 1 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0004771 hsa_circ_NRIP1 hsa_circRNA_103110 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 2 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0091894 hsa_circ_FLNA hsa_circRNA_105038 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 1 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0092315 hsa_circ_PWP2 hsa_circRNA_400064 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 1 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0078738 hsa_circ_WDR27 hsa_circRNA_104268 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 2 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0064557 hsa_circ_SATB1 hsa_circRNA_103307 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 1 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0000516 hsa_circ_RPPH1 hsa_circRNA_001379 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 1 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0004846 hsa_circ_SAMD4A hsa_circRNA_101356 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 1 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0003505 hsa_circ_USP22 hsa_circRNA_102002 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 1 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. hsa_circ_0081342 hsa_circ_ARPC1B hsa_circRNA_104433 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue." 1 The circular RNA ciRS-7 promotes APP and BACE1 degradation in an NF-kappaB-dependent manner. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR down-regulated "ciRS-7 expression inhibits translation of NF-kappaB and induces its cytoplasmic localization, thus derepressing expression of UCHL1, which promotes APP and BACE1 degradation." 1 Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value. hsa_circ_0023404 hsa_circ_RNF121 circRNA_100876 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircRNA 100876 is closely related to the carcinogenesis of NSCLC and it might be served as a potential prognostic biomarker and therapeutic target for NSCLC. 2 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. - hsa_circ_ZNF609 - DOID:11723 duchenne muscular dystrophy duchenne muscular dystrophy "RT-qPCR, RNA-seq" up-regulated "Circ-ZNF609 is associated with heavy polysomes, and it is translated into a protein in a splicing-dependent and cap-independent manner, providing an example of a protein-coding circRNA in eukaryotes." 1 Identification of differentially expressed circular RNAs in human colorectal cancer. - hsa_circ_ZFR hsa_circRNA_103809 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" down-regulated The expression levels of hsa_circRNA_103809 and hsa_circRNA_104700 were significantly downregulated in 170 CRC tissues and they were associated with tumor progression. 2 Identification of differentially expressed circular RNAs in human colorectal cancer. - hsa_circ_PTK2 hsa_circRNA_104700 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" down-regulated The expression levels of hsa_circRNA_103809 and hsa_circRNA_104700 were significantly downregulated in 170 CRC tissues and they were associated with tumor progression. 4 circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. hsa_circ_0013339 hsa_circ_SLC30A7 circRNA_100290 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, microarray" up-regulated CircRNA_100290 was upregulated and co-expressed with CDK6 in oral squamous cell carcinomas (OSCC) tissue. Knockdown of circRNA_100290 decreased expression of CDK6 and inhibited proliferation of OSCC cell lines in vitro and in vivo. 1 Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma. hsa_circ_0005986 hsa_circ_PRDM2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated Hsa_circ_0005986 downregulation liberated miR-129-5p and decreased the expression level of Notch1mRNA. hsa_circ_0005986 downregulation accelerated cell proliferation by promoting the G0/G1 to S phase transition. 2 "A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-beta1." - - circRNA_010567 DOID:114 heart disease diabetic myocardial fibrosis "RT-qPCR, microarray" up-regulated CircRNA_010567/miR-141/TGF-beta1 axis plays an important regulatory role in the diabetic mice myocardial fibrosis model. 1 Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens. - gga_circ_RAB6A chr1:194735582-194744050 DOID:934 viral infectious disease avian leukosis virus subgroup "RT-qPCR, RNA-seq" up-regulated Two randomly selected circRNAs that were upregulated in ALV-J-resistant chickens (chr1:194735582-194744050- and chr23:5549365-5549645-) and two randomly circRNAs that were downregulated in ALVJ-resistant chickens (chr8:1033880-1047222- and chr5:58225735-58230830-) were selected to validate the expression levels of the significantly differentially expressed circRNAs by quantitative real-time polymerase chain reaction (qRT-PCR). The qRT-PCR data for the four circRNAs was consistent with the trends observed using circRNA sequencing. 1 Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens. - gga_circ_HMGCL chr23:5549365-5549645 DOID:934 viral infectious disease avian leukosis virus subgroup "RT-qPCR, RNA-seq" up-regulated Two randomly selected circRNAs that were upregulated in ALV-J-resistant chickens (chr1:194735582-194744050- and chr23:5549365-5549645-) and two randomly circRNAs that were downregulated in ALVJ-resistant chickens (chr8:1033880-1047222- and chr5:58225735-58230830-) were selected to validate the expression levels of the significantly differentially expressed circRNAs by quantitative real-time polymerase chain reaction (qRT-PCR). The qRT-PCR data for the four circRNAs was consistent with the trends observed using circRNA sequencing. 1 Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens. - - chr8:1033880-1047222 DOID:934 viral infectious disease avian leukosis virus subgroup "RT-qPCR, RNA-seq" down-regulated Two randomly selected circRNAs that were upregulated in ALV-J-resistant chickens (chr1:194735582-194744050- and chr23:5549365-5549645-) and two randomly circRNAs that were downregulated in ALVJ-resistant chickens (chr8:1033880-1047222- and chr5:58225735-58230830-) were selected to validate the expression levels of the significantly differentially expressed circRNAs by quantitative real-time polymerase chain reaction (qRT-PCR). The qRT-PCR data for the four circRNAs was consistent with the trends observed using circRNA sequencing. 1 Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens. - - chr5:58225735-58230830 DOID:934 viral infectious disease avian leukosis virus subgroup "RT-qPCR, RNA-seq" down-regulated Two randomly selected circRNAs that were upregulated in ALV-J-resistant chickens (chr1:194735582-194744050- and chr23:5549365-5549645-) and two randomly circRNAs that were downregulated in ALVJ-resistant chickens (chr8:1033880-1047222- and chr5:58225735-58230830-) were selected to validate the expression levels of the significantly differentially expressed circRNAs by quantitative real-time polymerase chain reaction (qRT-PCR). The qRT-PCR data for the four circRNAs was consistent with the trends observed using circRNA sequencing. 1 Identification of the Spinal Expression Profile of Non-coding RNAs Involved in Neuropathic Pain Following Spared Nerve Injury by Sequence Analysis. - - rno_circ_0006928 DOID:936 brain disease neuropathic pain "RT-qPCR, RNA-seq" up-regulated "Our data showed that the most significantly involved pathways in SNI pathogenesis were ribosome, PI3K-Akt signaling pathway, focal adhesion, ECM-receptor interaction, amoebiasis and protein digestion and absorption. In addition, the lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA network of NP was constructed. This is the first study to comprehensively identify regulated ncRNAs of the spinal cord and to demonstrate the involvement of different ncRNA expression patterns in the spinal cord of NP pathogenesis by sequence analysis. " 1 Identification of the Spinal Expression Profile of Non-coding RNAs Involved in Neuropathic Pain Following Spared Nerve Injury by Sequence Analysis. - - rno circ 0004058 DOID:936 brain disease neuropathic pain "RT-qPCR, RNA-seq" up-regulated "Our data showed that the most significantly involved pathways in SNI pathogenesis were ribosome, PI4K-Akt signaling pathway, focal adhesion, ECM-receptor interaction, amoebiasis and protein digestion and absorption. In addition, the lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA network of NP was constructed. This is the first study to comprehensively identify regulated ncRNAs of the spinal cord and to demonstrate the involvement of different ncRNA expression patterns in the spinal cord of NP pathogenesis by sequence analysis." 1 Identification of the Spinal Expression Profile of Non-coding RNAs Involved in Neuropathic Pain Following Spared Nerve Injury by Sequence Analysis. - - rno circ 0005854 DOID:936 brain disease neuropathic pain "RT-qPCR, RNA-seq" down-regulated "Our data showed that the most significantly involved pathways in SNI pathogenesis were ribosome, PI5K-Akt signaling pathway, focal adhesion, ECM-receptor interaction, amoebiasis and protein digestion and absorption. In addition, the lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA network of NP was constructed. This is the first study to comprehensively identify regulated ncRNAs of the spinal cord and to demonstrate the involvement of different ncRNA expression patterns in the spinal cord of NP pathogenesis by sequence analysis." 1 "Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells." hsa_circ_0016347 hsa_circ_KCNH1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated We demonstrated that circ-0016347 acted as a positive regulator in osteosarcoma cells proliferation and invasion. 2 Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "CDR1as had a higher expression in CRC tissues compared to adjacent, normal mucosa and was positively associated with tumor size, T stage, lymph node metastasis, and poor overall survival (OS). Downregulation of CDR1as suppressed CRC cell proliferation and invasion and increased microRNA-7 (miR-7) expression. Intriguingly, ectopic expression of miR-7 in CRC cells consistently inhibited proliferation and invasion, and the miR-7 inhibitor was able to rescue the function of CDR1as knockdown. " 2 Decreased expression of hsa_circ_0001895 in human gastric cancer and its clinical significances. hsa_circ_0001895 hsa_circ_PRRC2B hsa_circ_000760 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Hsa_circ_0001895 may play crucial roles during gastric cancerogenesis and is a potential biomarker for clinical prognosis prediction. 2 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. hsa_circ_0004771 hsa_circ_NRIP1 hsa_circ_103110 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements." 2 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. hsa_circ_0001824 hsa_circ_ASAP1 hsa_circ_104689 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements." 1 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. hsa_circ_0001875 hsa_circ_FAM120A hsa_circ_104821 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements." 1 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. hsa_circ_0006054 hsa_circ_KIAA0355 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated "The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements." 1 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. hsa_circ_0004619 hsa_circ_FAF1 hsa_circ_100219 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated "The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements." 2 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. - - hsa_circ_406697 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated "The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements." 1 Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance. hsa_circ_0003570 hsa_circ_FAM53B - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated Hsa_circ_0003570 was closely correlated with the clinicopathological characteristics of patients with HCC and the background of cirrhosis was related to the decreased hsa_circ_0003570 in HCC patients. 3 Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression. - mmu_circ_Smyd4 mm9_circ_016597 DOID:1287 cardiovascular system disease cardiovascular disease RT-qPCR down-regulated "A circRNA (mitochondrial fission and apoptosis-related circRNA, termed as MFACR) regulates mitochondrial fission and apoptosis in the heart by directly targeting and downregulating miR-652-3p; this in turn blocks mitochondrial fission and cardiomyocyte cell death by suppressing MTP18 translation. Our results reveal a crucial role for circRNA in regulating mitochondrial dynamics and apoptosis in the heart; as such, circRNAs may serve as a potential therapeutic avenue for cardiovascular diseases." 1 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. hsa_circ_0058106 hsa_circ_FN1 - DOID:8533 hypopharynx cancer hypopharyngeal cancer "RT-qPCR, microarray" up-regulated "The expression levels of hsa_circ_0058106, hsa_circ_0058107, and hsa_circ_0024108 were significantly higher in tumor tissues than in corresponding normal tissues. These data were consistent with the results of the microarray data, indicating the reliability of these results." 2 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. hsa_circ_0058107 hsa_circ_FN1 - DOID:8533 hypopharynx cancer hypopharyngeal cancer "RT-qPCR, microarray" up-regulated "The expression levels of hsa_circ_0058106, hsa_circ_0058107, and hsa_circ_0024108 were significantly higher in tumor tissues than in corresponding normal tissues. These data were consistent with the results of the microarray data, indicating the reliability of these results." 2 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. hsa_circ_0024108 hsa_circ_MMP1 - DOID:8533 hypopharynx cancer hypopharyngeal cancer "RT-qPCR, microarray" up-regulated "The expression levels of hsa_circ_0058106, hsa_circ_0058107, and hsa_circ_0024108 were significantly higher in tumor tissues than in corresponding normal tissues. These data were consistent with the results of the microarray data, indicating the reliability of these results." 1 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. hsa_circ_0036722 hsa_circ_RHCG - DOID:8533 hypopharynx cancer hypopharyngeal cancer "RT-qPCR, microarray" down-regulated "Hsa_circ_0036722, hsa_circ_0002260, and hsa_circ_0001189 expression levels were significantly decreased in tumor tissues compared with normal controls. These data were consistent with the results of the microarray data, indicating the reliability of these results." 1 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. hsa_circ_0002260 hsa_circ_PAPD4 - DOID:8533 hypopharynx cancer hypopharyngeal cancer "RT-qPCR, microarray" down-regulated "Hsa_circ_0036722, hsa_circ_0002260, and hsa_circ_0001189 expression levels were significantly decreased in tumor tissues compared with normal controls. These data were consistent with the results of the microarray data, indicating the reliability of these results." 1 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. hsa_circ_0001189 hsa_circ_MORC3 - DOID:8533 hypopharynx cancer hypopharyngeal cancer "RT-qPCR, microarray" down-regulated "Hsa_circ_0036722, hsa_circ_0002260, and hsa_circ_0001189 expression levels were significantly decreased in tumor tissues compared with normal controls. These data were consistent with the results of the microarray data, indicating the reliability of these results." 2 Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. hsa_circ_0007874 hsa_circ_MTO1 hsa_circ_104135 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "CircMTO1 suppresses HCC progression by acting as the sponge of oncogenic miR-9 to promote p21 expression, suggesting that circMTO1 is a potential target in HCC treatment. The decrease of circMTO1 in HCC tissues may serve as a prognosis predictor for poor survival of patients." 3 Profiling and bioinformatics analyses reveal differential circular RNA expression in hypertensive patients. hsa_circ_0005870 hsa_circ_SETD2 - DOID:10763 hypertension hypertension "RT-qPCR, microarray" down-regulated Gene oncology and KEGG pathway analysis enriched from specific mRNAs indicated the involvement of hsa-circ-0005870 in hypertension. 1 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0014717 hsa_circ_CCT3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated Hsa_circ_0014717 stably exists in human gastric juice and significantly decreased in chronic atrophic gastritis group. 2 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0035445 hsa_circ_ALDH1A2 - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1." 1 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0003789 hsa_circ_TSN - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1." 1 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0063809 hsa_circ_CELSR1 - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1." 1 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0074362 hsa_circ_ARHGAP26 - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1." 3 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0006282 hsa_circ_TCEB1 - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1." 3 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0011107 hsa_circ_RPA2 - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1." 1 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0084606 hsa_circ_ASPH - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1." 1 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0005556 hsa_circ_NBAS - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1." 3 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0050547 hsa_circ_UBA2 - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1." 1 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0006470 hsa_circ_MFN2 - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1." 5 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0007099 hsa_circ_ABHD2 - DOID:10534 stomach cancer gastric cancer microarray down-regulated "The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1." 2 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0001897 hsa_circ_POMT1 - DOID:10534 stomach cancer gastric cancer microarray down-regulated "The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1." 2 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0007707 hsa_circ_LCOR - DOID:10534 stomach cancer gastric cancer microarray down-regulated "The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1." 2 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0008832 hsa_circ_FBXO7 - DOID:10534 stomach cancer gastric cancer microarray down-regulated "The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1." 1 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0001546 hsa_circ_FAM114A2 - DOID:10534 stomach cancer gastric cancer microarray down-regulated "The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1." 2 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0002089 hsa_circ_ARHGEF12 - DOID:10534 stomach cancer gastric cancer microarray down-regulated "The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1." 1 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0004680 hsa_circ_CCT3 - DOID:10534 stomach cancer gastric cancer microarray down-regulated "The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1." 2 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0000154 hsa_circ_DCAF6 - DOID:10534 stomach cancer gastric cancer microarray down-regulated "The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1." 2 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0004458 hsa_circ_PSD3 - DOID:10534 stomach cancer gastric cancer microarray down-regulated "The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1." 1 Global circular RNA expression profile of human gastric cancer and its clinical significance. hsa_circ_0008394 hsa_circ_TIMMDC1 - DOID:10534 stomach cancer gastric cancer microarray down-regulated "The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1." 1 Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Overexpression of ciRS-7 blocked the miR-7-induced tumor suppression in MGC-803 and HGC-27 cells and led to a more aggressive oncogenic phenotype, via antagonizing miR-7-mediated PTEN/PI3K/AKT pathway." 2 Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance. hsa_circ_0003159 hsa_circ_CACNA2D1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Hsa_circ_0003159 expression levels were significantly negatively associated with gender, distal metastasis, and tumor-node-metastasis stage. Hsa_circ_0003159 may be a potential cancer marker of patients with gastric cancer." 3 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. - hsa_circ_SUSD1 circRNA_104871 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" up-regulated "Increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis." 2 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. - hsa_circ_FAM168B circRNA_003524 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" up-regulated "Increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis." 2 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. - hsa_circ_GLG1 circRNA_101873 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" up-regulated "Increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis." 1 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. - hsa_circ_FAM168B circRNA_103047 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" up-regulated "Increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis." 2 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. - hsa_circ_XBP1 circRNA_092516 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" up-regulated "Consistent with the microarray data, the average expression levels of circRNA_092516, circRNA_003524, circRNA_103047, circRNA_104871, and circRNA_101873 in the PBMCs of patients with RA were significantly higher than those of the healthy controls." 1 A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation. hsa_circ_0004214 hsa_circ_AMOTL1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Single-cell inoculations using circ-Amotl1-transfected tumor cells showed a 30-fold increase in proliferative capacity relative to control. this potent tumorigenicity was triggered through interactions between circ-Amotl1 and c-myc. 2 A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation. hsa_circ_0004214 hsa_circ_AMOTL1 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated Expression of circ-Amotl1 was analyzed in a variety of cell lines by real-time PCR. Nine cancer cell lines expressed higher levels of circ-Amotl1 relative to two non-cancer cell lines HaCaTand MCF-10A. 2 A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation. hsa_circ_0004214 hsa_circ_AMOTL1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Expression of circ-Amotl1 was analyzed in a variety of cell lines by real-time PCR. Nine cancer cell lines expressed higher levels of circ-Amotl1 relative to two non-cancer cell lines HaCaTand MCF-10A. 3 A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation. hsa_circ_0004214 hsa_circ_AMOTL1 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Expression of circ-Amotl1 was analyzed in a variety of cell lines by real-time PCR. Nine cancer cell lines expressed higher levels of circ-Amotl1 relative to two non-cancer cell lines HaCaTand MCF-10A. 1 Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis. - - hsa_circRNA_000598 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" up-regulated Our results demonstrated that circRNAs-MSR regulated TNF-alpha expression and participated in the chondrocyte ECM degradation process. We propose that the inhibition of circRNAs-MSR could inhibit the degradation of chondrocyte ECM and knockdown of circRNAs-MSR could be a potential therapeutic target for OA. 1 Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis. - - hsa_circRNA_103387 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" up-regulated Our results demonstrated that circRNAs-MSR regulated TNF-alpha expression and participated in the chondrocyte ECM degradation process. We propose that the inhibition of circRNAs-MSR could inhibit the degradation of chondrocyte ECM and knockdown of circRNAs-MSR could be a potential therapeutic target for OA. 1 Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis. - - hsa_circRNA_101975 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" up-regulated Our results demonstrated that circRNAs-MSR regulated TNF-alpha expression and participated in the chondrocyte ECM degradation process. We propose that the inhibition of circRNAs-MSR could inhibit the degradation of chondrocyte ECM and knockdown of circRNAs-MSR could be a potential therapeutic target for OA. 1 Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis. - - circRNA_100226 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" up-regulated Our results demonstrated that circRNAs-MSR regulated TNF-alpha expression and participated in the chondrocyte ECM degradation process. We propose that the inhibition of circRNAs-MSR could inhibit the degradation of chondrocyte ECM and knockdown of circRNAs-MSR could be a potential therapeutic target for OA. 1 Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Circ-ITCH may have an inhibitory effect on HCC, and could serve as susceptibility and prognostic biomarkers for HCC patients." 5 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. hsa_circ_0058246 hsa_circ_VIL1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "In particular, we found that the expression of hsa_circ_0058246 was elevated in tumor specimens of patients with poor clinical outcomes." 1 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. hsa_circ_0091742 hsa_circ_BGN - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible." 2 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. hsa_circ_0089548 hsa_circ_NOTCH1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible." 3 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. hsa_circ_0003707 hsa_circ_CD44 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible." 2 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. hsa_circ_0085553 hsa_circ_PVT1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible." 6 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. hsa_circ_0006022 hsa_circ_LYN - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible." 1 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. hsa_circ_0031979 hsa_circ_CDKN3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible." 1 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. hsa_circ_0069131 hsa_circ_AFAP1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible." 1 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. - - hsa_circRNA_103827 DOID:1100 ovarian disease ovarian aging microarray up-regulated "Age-related up-regulation of circRNA_103827 and circRNA_104816 might be potential indicators of compromised follicular micro-environment which could be used to predict IVF prognosis, and improve female infertility management." 1 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. - - hsa_circRNA_104816 DOID:1100 ovarian disease ovarian aging microarray up-regulated "Age-related up-regulation of circRNA_103827 and circRNA_104816 might be potential indicators of compromised follicular micro-environment which could be used to predict IVF prognosis, and improve female infertility management." 1 Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis. hsa_circ_0005402 hsa_circ_ANXA2 hsa_circRNA_101539 DOID:2377 multiple sclerosis multiple sclerosis "RT-qPCR, microarray" down-regulated "We carried out expression profiling of 13617 circular RNA in peripheral blood leucocytes from multiple sclerosis patients and healthy controls finding 406 differentially expressed and demonstrate after validation that, circ_0005402 and circ_0035560 are underexpressed in multiple sclerosis patients and could be used as biomarkers of the disease." 2 Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis. hsa_circ_0035560 hsa_circ_ANXA2 hsa_circRNA_101541 DOID:2377 multiple sclerosis multiple sclerosis "RT-qPCR, microarray" down-regulated "We carried out expression profiling of 13617 circular RNA in peripheral blood leucocytes from multiple sclerosis patients and healthy controls finding 406 differentially expressed and demonstrate after validation that, circ_0005402 and circ_0035560 are underexpressed in multiple sclerosis patients and could be used as biomarkers of the disease." 2 Multiple Isoforms of ANRIL in Melanoma Cells: Structural Complexity Suggests Variations in Processing. - hsa_circ_ANRIL - DOID:1909 melanoma melanoma RT-qPCR dysregulated we hypothesise that ANRIL has wholly distinct dual sets of functions in melanoma. This reveals the dynamic nature of the locus and constitutes a basis for investigating the functions of ANRIL in melanoma. 1 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0007031 hsa_circ_TUBGCP3 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 4 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0000504 hsa_circ_TUBGCP3 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 4 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0007006 hsa_circ_DYM - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 1 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0000237 hsa_circ_HNRNPF - DOID:9256 colorectal cancer colorectal cancer microarray up-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 1 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0074930 hsa_circ_SLIT3 - DOID:9256 colorectal cancer colorectal cancer microarray up-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 1 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0084353 hsa_circ_PRKDC - DOID:9256 colorectal cancer colorectal cancer microarray up-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 4 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0022080 hsa_circ_NUP160 - DOID:9256 colorectal cancer colorectal cancer microarray up-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 1 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0008494 hsa_circ_ARID1A - DOID:9256 colorectal cancer colorectal cancer microarray up-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 1 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0005949 hsa_circ_ZNF608 - DOID:9256 colorectal cancer colorectal cancer microarray up-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 1 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0074806 hsa_circ_CLINT1 - DOID:9256 colorectal cancer colorectal cancer microarray up-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 1 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0048232 hsa_circ_DAZAP1 - DOID:9256 colorectal cancer colorectal cancer microarray down-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 1 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0006174 hsa_circ_RAD23B - DOID:9256 colorectal cancer colorectal cancer microarray down-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 5 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0008509 hsa_circ_NAV3 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" down-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 1 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0084021 hsa_circ_PLEKHA2 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" down-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 1 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. hsa_circ_0087862 hsa_circ_RAD23B - DOID:9256 colorectal cancer colorectal cancer microarray down-regulated "To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006." 4 Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances. hsa_circ_0006633 hsa_circ_FGGY - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Hsa_circ_0006633 may play an important role in gastric carcinogenesis and is also a potential biomarker for screening gastric cancer. 1 CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630. - hsa_circ_LPHN2 circRNA_100269 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Overexpressing the circRNA_100269 plasmid inhibited cell proliferation. circRNA_100269 and miR-630 comprise a novel pathway that regulates proliferation of GC cells. 1 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. - hsa_circ_SLC8A1 - DOID:1287 cardiovascular system disease cardiovascular disease RNA-seq up-regulated "We validated the same circRNA dynamics for circRNAs from ATXN10, CHD7, DNAJC6 and SLC8A1 in biopsy material from human dilated cardiomyopathy (DCM) and control patients. Finally, we could show that rodent homologs of circMYOD, circSLC8A1, circATXN7 and circPHF21A interact with either the ribosome or Argonaute2 protein complexes." 1 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. - hsa_circ_CHD7 - DOID:1287 cardiovascular system disease cardiovascular disease RNA-seq up-regulated "We validated the same circRNA dynamics for circRNAs from ATXN10, CHD7, DNAJC6 and SLC8A1 in biopsy material from human dilated cardiomyopathy (DCM) and control patients. Finally, we could show that rodent homologs of circMYOD, circSLC8A1, circATXN7 and circPHF21A interact with either the ribosome or Argonaute3 protein complexes." 1 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. - hsa_circ_ATXN10 - DOID:1287 cardiovascular system disease cardiovascular disease RNA-seq up-regulated "We validated the same circRNA dynamics for circRNAs from ATXN10, CHD7, DNAJC6 and SLC8A1 in biopsy material from human dilated cardiomyopathy (DCM) and control patients. Finally, we could show that rodent homologs of circMYOD, circSLC8A1, circATXN7 and circPHF21A interact with either the ribosome or Argonaute4 protein complexes." 1 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. - hsa_circ_DNAJ6C - DOID:1287 cardiovascular system disease cardiovascular disease RNA-seq down-regulated "We validated the same circRNA dynamics for circRNAs from ATXN10, CHD7, DNAJC6 and SLC8A1 in biopsy material from human dilated cardiomyopathy (DCM) and control patients. Finally, we could show that rodent homologs of circMYOD, circSLC8A1, circATXN7 and circPHF21A interact with either the ribosome or Argonaute5 protein complexes." 1 Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes. - - hsa_circ_101396 DOID:936 brain disease leukoaraiosis "RT-qPCR, microarray" up-regulated The results of the present study indicated that the DE genes from differently expressed circRNAs may have an important role in the pathogenesis of LA and may be a novel targfet for further research. 1 Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes. - - hsa_circ_102533 DOID:936 brain disease leukoaraiosis "RT-qPCR, microarray" up-regulated The results of the present study indicated that the DE genes from differently expressed circRNAs may have an important role in the pathogenesis of LA and may be a novel targfet for further research. 1 Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes. - - hsa_circ_103783 DOID:936 brain disease leukoaraiosis "RT-qPCR, microarray" up-regulated The results of the present study indicated that the DE genes from differently expressed circRNAs may have an important role in the pathogenesis of LA and may be a novel targfet for further research. 1 Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes. - - hsa_circ_102470 DOID:936 brain disease leukoaraiosis "RT-qPCR, microarray" down-regulated The results of the present study indicated that the DE genes from differently expressed circRNAs may have an important role in the pathogenesis of LA and may be a novel targfet for further research. 1 Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension. hsa_circ_0002062 hsa_circ_PTK2 - DOID:6432 pulmonary hypertension chronic thromboembolic pulmonary hypertension microarray down-regulated "Combining these findings with the results of our present study showing that hsa_circ_0002062 regulated hsa-miR-942-5p, we suggested that circRNAs function in CTEPH via hsa_circ_0002062-hsa-miR-942-5p-CDK6-pathways involved in cancer." 1 Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension. hsa_circ_0022342 hsa_circ_SYT7 - DOID:6432 pulmonary hypertension chronic thromboembolic pulmonary hypertension microarray down-regulated "Combined with the results of our present study showing that hsa_circ_002234 regulated hsa-miR-940, we suggested that circRNAs play potential roles in CTEPH via the hsa_circ_0022342-hsa-miR-940-CRKL-ErbB signaling pathway." 1 Effect of Circular ANRIL on the Inflammatory Response of Vascular Endothelial Cells in a Rat Model of Coronary Atherosclerosis. - rno_circ_ANRIL cANRIL DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Our study provides evidence that reduced cANRIL expression could prevent coronary AS by reducing vascular EC apoptosis and inflammatory factor expression. 1 hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma. hsa_circ_0013958 hsa_circ_ACP6 - DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" up-regulated Hsa_circ_0013958 promoted cell proliferation and invasion and inhibited cell apoptosis in lung adenocarcinoma (LAC). 1 Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway. hsa_circ_0002768 hsa_circ_MYLK - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "CircRNA-MYLK might function as competing endogenous RNA (ceRNA) for miR-29a, which could contribute to EMT and the development of bladder carcinoma through activating VEGFA/VEGFR2 and downstream Ras/ERK signaling pathway." 3 MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839. - - circRNA_000839 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Our mechanistic data indicate that RhoA is a direct target of miR-200b, binding of which affects the expression of invasion and migration in hepatocellular carcinoma cell lines. And correlation analysis showed that miR-200b was inversely correlated with RhoA and circ_000839, while RhoA was positively correlated with circ_000839." 1 "Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p." hsa_circ_0056288 hsa_circ_GLI2 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p." 1 "Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1." hsa_circ_0020397 hsa_circ_DOCK1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Hsa_circ_0020397 can regulate colorectal cancer (CRC) cell viability, apoptosis, and invasion by promoting the expression of miR-138 target genes." 4 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. - hsa_circ_SNX27 hsa_circRNA_100338 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated The crucial antagonistic roles of circRNA_100338 and miR-141-3p in the regulation of invasive potential in liver cancer cells. 3 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. - hsa_circ_NUP153 hsa_circRNA_104075 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Despite the great genomic variations among the different patients, we were still able to identify two circRNAs (hsa_circRNA_104075 and hsa_circRNA_100338) that were significantly up-regulated in HCC samples compared with paired pericancerous tissue samples. These results further validated our findings and implied that these circRNAs may play important roles in HCC carcinogenesis." 1 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. - - hsa_circRNA_002082 DOID:9452 fatty liver disease hepatic steatosis "RT-qPCR, microarray" down-regulated "In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014724 showed an opposite expression pattern." 1 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. - - hsa_circRNA_000367 DOID:9452 fatty liver disease hepatic steatosis "RT-qPCR, microarray" down-regulated "In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014725 showed an opposite expression pattern." 1 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. - - hsa_circRNA_004183 DOID:9452 fatty liver disease hepatic steatosis "RT-qPCR, microarray" down-regulated "In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014726 showed an opposite expression pattern." 1 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. - - hsa_circRNA_007850 DOID:9452 fatty liver disease hepatic steatosis "RT-qPCR, microarray" up-regulated "In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014727 showed an opposite expression pattern." 1 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. - - hsa_circRNA_004121 DOID:9452 fatty liver disease hepatic steatosis "RT-qPCR, microarray" up-regulated "In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014728 showed an opposite expression pattern." 1 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. - - hsa_circRNA_014724 DOID:9452 fatty liver disease hepatic steatosis "RT-qPCR, microarray" up-regulated "In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014729 showed an opposite expression pattern." 1 Construction and analysis of circular RNA molecular regulatory networks in liver cancer. hsa_circ_0072088 hsa_circ_ZFR - DOID:3571 liver cancer liver cancer "RT-qPCR, microarray" up-regulated "Representation of the data using an ROC plot showed circZFR, circFUT8, circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7069, 0.7575, and 0.7103, respectively." 1 Construction and analysis of circular RNA molecular regulatory networks in liver cancer. hsa_circ_0003028 hsa_circ_FUT8 - DOID:3571 liver cancer liver cancer "RT-qPCR, microarray" up-regulated "Representation of the data using an ROC plot showed circZFR, circFUT8, circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7069, 0.7575, and 0.7103, respectively." 1 Construction and analysis of circular RNA molecular regulatory networks in liver cancer. hsa_circ_0007915 hsa_circ_IPO11 - DOID:3571 liver cancer liver cancer "RT-qPCR, microarray" up-regulated "Representation of the data using an ROC plot showed circZFR, circFUT8, circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7069, 0.7575, and 0.7103, respectively." 2 Expression profile of circular RNAs in human gastric cancer tissues. hsa_circ_0000026 hsa_circ_EIF4G3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues. 4 Expression profile of circular RNAs in human gastric cancer tissues. hsa_circ_0005927 hsa_circ_VDAC3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues. 2 Expression profile of circular RNAs in human gastric cancer tissues. hsa_circ_0092341 hsa_circ_C6orf132 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues. 1 Expression profile of circular RNAs in human gastric cancer tissues. hsa_circ_0000144 hsa_circ_SLAMF6 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues. 3 Expression profile of circular RNAs in human gastric cancer tissues. hsa_circ_0061274 hsa_circ_NRIP1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues. 6 Expression profile of circular RNAs in human gastric cancer tissues. hsa_circ_0032821 hsa_circ_CEP128 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues. 3 Expression profile of circular RNAs in human gastric cancer tissues. hsa_circ_0005529 hsa_circ_VPS33B - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues. 3 [Circular RNA CircHIPK3 Promotes NCI-H1299 and NCI-H2170 Cell Proliferation through miR-379 and its Target IGF1]. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated CircHIPK3 could promote cell proliferation by a circHIPK3/miR-379 pathway in NCI-H1299 and NCI-H2170 cells and might be a potential tumor biomarker for NSCLC. 4 HIF1alpha-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment. - hsa_circ_DENND4C - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Knocking-down circDENND4C inhibited proliferation of breast cancer cells in a hypoxic environment. 2 Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. hsa_circ_0008717 hsa_circ_ABCB10 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "Results identified a new functional circ-ABCB10 in breast cancer tumorigenesis, and reveal the important regulatory role of circ-ABCB10 through sponging miR-1271, providing a novel insight for breast cancer pathogenesis." 2 Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells. - - circ-104916 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Overexpression of circ-104916 effectively inhibited the proliferation, migration and invasion abilities of GC cells in vitro." 1 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. - - rno_circRNA_013779 DOID:936 brain disease neuropathic pain "RT-qPCR, microarray" up-regulated CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain. 1 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. - - rno_circRNA_008646 DOID:936 brain disease neuropathic pain "RT-qPCR, microarray" up-regulated CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain. 1 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. - - rno_circRNA_35215 DOID:936 brain disease neuropathic pain "RT-qPCR, microarray" up-regulated CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain. 1 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. - - rno_circRNA_008973 DOID:936 brain disease neuropathic pain "RT-qPCR, microarray" up-regulated CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain. 1 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. - - rno_circRNA_011111 DOID:936 brain disease neuropathic pain "RT-qPCR, microarray" down-regulated CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain. 1 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. - - rno_circRNA_007419 DOID:936 brain disease neuropathic pain "RT-qPCR, microarray" down-regulated CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain. 1 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. - - rno_circRNA_007512 DOID:936 brain disease neuropathic pain "RT-qPCR, microarray" down-regulated CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain. 1 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. - - rno_circRNA_010913 DOID:936 brain disease neuropathic pain "RT-qPCR, microarray" down-regulated CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain. 1 Androgen-responsive circular RNA circSMARCA5 is up-regulated and promotes cell proliferation in prostate cancer. hsa_circ_0001445 hsa_circ_SMARCA5 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated Functional experiments showed circ-SMARCA5 acted as an oncogene in prostate cancer by promoting cell cycle and inhibiting cell apoptosis. 2 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. hsa_circ_0071410 hsa_circ_PALLD - DOID:409 liver disease liver fibrosis "RT-qPCR, microarray" up-regulated "Inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced hepatic stellate cell (HSC) activation." 1 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. hsa_circ_0072765 hsa_circ_CCNB1 - DOID:409 liver disease liver fibrosis "RT-qPCR, microarray" up-regulated "Hsa_circ_0072765, hsa_circ_0071410, hsa_circ_0054345 were significantly up-regulated in irradiated hepatic stellate cell (HSC) compared with normal HSC, while hsa_circ_0070963, hsa_circ_0061893, hsa_circ_0013255 were significantly down-regulated." 2 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. hsa_circ_0054345 hsa_circ_LRPPRC - DOID:409 liver disease liver fibrosis "RT-qPCR, microarray" up-regulated "Hsa_circ_0072765, hsa_circ_0071410, hsa_circ_0054345 were significantly up-regulated in irradiated hepatic stellate cell (HSC) compared with normal HSC, while hsa_circ_0070963, hsa_circ_0061893, hsa_circ_0013255 were significantly down-regulated." 1 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. hsa_circ_0070963 hsa_circ_SCLT1 - DOID:409 liver disease liver fibrosis "RT-qPCR, microarray" down-regulated "Hsa_circ_0072765, hsa_circ_0071410, hsa_circ_0054345 were significantly up-regulated in irradiated hepatic stellate cell (HSC) compared with normal HSC, while hsa_circ_0070963, hsa_circ_0061893, hsa_circ_0013255 were significantly down-regulated." 2 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. hsa_circ_0061893 hsa_circ_PDXK - DOID:409 liver disease liver fibrosis "RT-qPCR, microarray" down-regulated "Hsa_circ_0072765, hsa_circ_0071410, hsa_circ_0054345 were significantly up-regulated in irradiated hepatic stellate cell (HSC) compared with normal HSC, while hsa_circ_0070963, hsa_circ_0061893, hsa_circ_0013255 were significantly down-regulated." 1 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. hsa_circ_0013255 hsa_circ_DPYD - DOID:409 liver disease liver fibrosis "RT-qPCR, microarray" down-regulated "Hsa_circ_0072765, hsa_circ_0071410, hsa_circ_0054345 were significantly up-regulated in irradiated hepatic stellate cell (HSC) compared with normal HSC, while hsa_circ_0070963, hsa_circ_0061893, hsa_circ_0013255 were significantly down-regulated." 1 Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus. - - hsa-circRNA11783-2 DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" down-regulated The crude odds ratios and adjusted odds ratios of hsa-circRNA11783-2 showed significant differences in both the coronary artery disease group and type 2 diabetes mellitus group. 1 Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus. - - hsa-circRNA11783-2 DOID:9352 type 2 diabetes mellitus type 2 diabetes mellitus "RT-qPCR, microarray" down-regulated The crude odds ratios and adjusted odds ratios of hsa-circRNA11783-2 showed significant differences in both the coronary artery disease group and type 2 diabetes mellitus group. 1 Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus. - - hsa-circRNA11806-28 DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" down-regulated "The levels of hsa-circRNA11806-28, hsa-circRNA6510-1 and hsa-circRNA11783-2 were significantly lower in both the T2DM group and CAD group compared with the control group." 1 Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus. - - hsa-circRNA11806-28 DOID:9352 type 2 diabetes mellitus type 2 diabetes mellitus "RT-qPCR, microarray" down-regulated "The levels of hsa-circRNA11806-28, hsa-circRNA6510-1 and hsa-circRNA11783-2 were significantly lower in both the T2DM group and CAD group compared with the control group." 1 Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus. - - hsa-circRNA6510-1 DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" down-regulated "The levels of hsa-circRNA11806-28, hsa-circRNA6510-1 and hsa-circRNA11783-2 were significantly lower in both the T2DM group and CAD group compared with the control group." 1 Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus. - - hsa-circRNA6510-1 DOID:9352 type 2 diabetes mellitus type 2 diabetes mellitus "RT-qPCR, microarray" down-regulated "The levels of hsa-circRNA11806-28, hsa-circRNA6510-1 and hsa-circRNA11783-2 were significantly lower in both the T2DM group and CAD group compared with the control group." 1 Circular RNAs in rat models of cardiovascular and renal diseases. - - rno_circRNA_006016 DOID:10763 hypertension hypertension RT-qPCR down-regulated our study is the primary report of profiling circRNAs in renal tissue and illustrates that circRNAs could be candidate genetic factors controlling blood pressure. 1 Carotid Plaque Rupture Is Accompanied by an Increase in the Ratio of Serum circR-284 to miR-221 Levels. - - circR-284 DOID:6713 cerebrovascular disease carotid disease and ischemic stroke RT-qPCR up-regulated Our data demonstrate that the serum ratio of circulating circR-284 to miR-221 is elevated in patients presenting with an acute carotid-related ischemic event and has the potential to serve as a diagnostic biomarker for carotid-related cerebrovascular ischemia. 1 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_003251 DOID:9351 diabetes mellitus diabetes "RT-qPCR, microarray" up-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T2DM and could represent novel molecular targets for clinical diagnosis and therapy." 2 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_015115 DOID:9351 diabetes mellitus diabetes "RT-qPCR, microarray" up-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T3DM and could represent novel molecular targets for clinical diagnosis and therapy." 2 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_100918 DOID:9351 diabetes mellitus diabetes "RT-qPCR, microarray" up-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T4DM and could represent novel molecular targets for clinical diagnosis and therapy." 2 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_005019 DOID:9351 diabetes mellitus diabetes "RT-qPCR, microarray" down-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T5DM and could represent novel molecular targets for clinical diagnosis and therapy." 2 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_003251 DOID:9351 diabetes mellitus diabetes "RT-qPCR, microarray" up-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T6DM and could represent novel molecular targets for clinical diagnosis and therapy." 2 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_015115 DOID:9351 diabetes mellitus diabetes "RT-qPCR, microarray" up-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T7DM and could represent novel molecular targets for clinical diagnosis and therapy." 2 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_100918 DOID:9351 diabetes mellitus diabetes "RT-qPCR, microarray" up-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T8DM and could represent novel molecular targets for clinical diagnosis and therapy." 2 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_005019 DOID:9351 diabetes mellitus diabetes "RT-qPCR, microarray" down-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T9DM and could represent novel molecular targets for clinical diagnosis and therapy." 2 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_003251 DOID:1596 depressive disorder depression "RT-qPCR, microarray" up-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T10DM and could represent novel molecular targets for clinical diagnosis and therapy." 1 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_015115 DOID:1596 depressive disorder depression "RT-qPCR, microarray" up-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T11DM and could represent novel molecular targets for clinical diagnosis and therapy." 1 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_100918 DOID:1596 depressive disorder depression "RT-qPCR, microarray" up-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T12DM and could represent novel molecular targets for clinical diagnosis and therapy." 1 Relationships of circular RNA with diabetes and depression. - - hsa_circRNA_005019 DOID:1596 depressive disorder depression "RT-qPCR, microarray" down-regulated "KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T13DM and could represent novel molecular targets for clinical diagnosis and therapy." 1 Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. - hsa_circ_HIPK2 - DOID:231 motor neuron disease neuroinflammatory disorders RT-qPCR up-regulated "the circular RNA HIPK2 (circHIPK2) functions as an endogenous microRNA-124 (MIR124-2HG) sponge to sequester MIR124-2HG and inhibit its activity, resulting in increased sigma non-opioid intracellular receptor 1 (SIGMAR1/OPRS1) expression." 1 CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "Over-expression of circHIPK3 effectively inhibits migration, invasion, and angiogenesis of bladder cancer cells in vitro and suppresses bladder cancer growth and metastasis in vivo." 4 "Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R." hsa_circ_0045714 hsa_circ_UNK - DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated hsa_circ_0045714 can regulate extracellular matrix synthesis as well as proliferation and apoptosis of chondrocytes by promoting the expression of miR-193b target gene IGF1R. The findings will provide new proofs for studies on the applications of circRNA in OA and other orthopedic diseases. 4 Screening circular RNA related to chemotherapeutic resistance in breast cancer. hsa_circ_0006528 hsa_circ_PRELID2 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated Hsa_circ_0006528 expression is significantly associated with ADM-resistant breast cancers and demonstrate the potential function of hsa_circ_0006528 in overcoming chemotherapy resistance in breast cancer. 4 Screening circular RNA related to chemotherapeutic resistance in breast cancer. hsa_circ_0002113 hsa_circ_IFNGR2 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified." 1 Screening circular RNA related to chemotherapeutic resistance in breast cancer. hsa_circ_0002874 hsa_circ_GLIS3 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified." 1 Screening circular RNA related to chemotherapeutic resistance in breast cancer. hsa_circ_0001667 hsa_circ_HEATR2 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified." 4 Screening circular RNA related to chemotherapeutic resistance in breast cancer. hsa_circ_0085495 hsa_circ_TMEM65 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified." 1 Screening circular RNA related to chemotherapeutic resistance in breast cancer. hsa_circ_0086241 hsa_circ_RFX3 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified." 1 Screening circular RNA related to chemotherapeutic resistance in breast cancer. hsa_circ_0092276 hsa_circ_NISCH - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified." 1 Screening circular RNA related to chemotherapeutic resistance in breast cancer. hsa_circ_0003838 hsa_circ_TTBK2 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated "To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified." 1 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. - - hsa_circRNA_063981 DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy. 1 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. - - hsa_circRNA_404457 DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy. 1 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. - - hsa_circRNA_100750 DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy. 1 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. - - hsa_circRNA_406918 DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy. 1 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. - - hsa_circRNA_104387 DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy. 1 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. - - hsa_circRNA_103410 DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy. 1 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. - - hsa_circRNA_100192 DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy. 1 Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction. - hsa_circ_ZNF609 - DOID:178 vascular disease vascular endothelial dysfunction RT-qPCR up-regulated "cZNF609 was significantly up-regulated upon high glucose and hypoxia stress in vivo and in vitro. cZNF609 silencing decreased retinal vessel loss and suppressed pathological angiogenesis in vivo. cZNF609 silencing increased endothelial cell migration and tube formation, and protected endothelial cell against oxidative stress and hypoxia stress in vitro." 1 Circular RNAs expression profiles in human gastric cancer. hsa_circ_0076304 hsa_circ_PGC - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in gastric cancer (GC). " 2 Circular RNAs expression profiles in human gastric cancer. hsa_circ_0035431 hsa_circ_CGNL1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in gastric cancer (GC). " 1 Circular RNAs expression profiles in human gastric cancer. hsa_circ_0076305 hsa_circ_PGC - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in gastric cancer (GC). " 2 The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis. hsa_circ_0005836 hsa_circ_TRAPPC6B - DOID:399 tuberculosis active tuberculosis "RT-qPCR, RNA-seq" down-regulated "We found that the expression of hsa_circ_0005836 was down-regulated by 2.586 folds in the active pulmonary tuberculosis (APTB) patients compared to the health control group (P < 0.0001), which was consistent with the RNA-seq results." 2 The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis. hsa_circ_0009128 hsa_circ_TXNDC11 - DOID:399 tuberculosis active tuberculosis "RT-qPCR, RNA-seq" down-regulated The hsa_circ_0009128 was decreased in active pulmonary tuberculosis (APTB) patients on a larger cohort being different from that of smaller cohort. 1 Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:178 vascular disease retinal vascular dysfunction "RT-qPCR, RNA-seq" up-regulated "The circular RNA circHIPK3 plays a role in diabetic retinopathy by blocking miR-30a function, leading to increased endothelial proliferation and vascular dysfunction. These data suggest that circular RNA is a potential target to control diabetic proliferative retinopathy." 1 The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study. - - mmu_circRNA_19423 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome "RT-qPCR, microarray" up-regulated "Among them, only 4 up-regulated circRNAs (mmu_circRNA_19423, rno_circRNA_010489, rno_circRNA_011426, mmu_circRNA_30664) and 1 down-regulated circRNA (rno_circRNA_005564) exhibited significant validation." 1 The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study. - - rno_circRNA_010489 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome "RT-qPCR, microarray" up-regulated "Among them, only 4 up-regulated circRNAs (mmu_circRNA_19423, rno_circRNA_010489, rno_circRNA_011426, mmu_circRNA_30664) and 1 down-regulated circRNA (rno_circRNA_005565) exhibited significant validation." 1 The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study. - - rno_circRNA_011426 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome "RT-qPCR, microarray" up-regulated "Among them, only 4 up-regulated circRNAs (mmu_circRNA_19423, rno_circRNA_010489, rno_circRNA_011426, mmu_circRNA_30664) and 1 down-regulated circRNA (rno_circRNA_005566) exhibited significant validation." 1 The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study. - - mmu_circRNA_30664 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome "RT-qPCR, microarray" up-regulated "Among them, only 4 up-regulated circRNAs (mmu_circRNA_19423, rno_circRNA_010489, rno_circRNA_011426, mmu_circRNA_30664) and 1 down-regulated circRNA (rno_circRNA_005567) exhibited significant validation." 1 The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study. - - rno_circRNA_005564 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome "RT-qPCR, microarray" down-regulated "Among them, only 4 up-regulated circRNAs (mmu_circRNA_19423, rno_circRNA_010489, rno_circRNA_011426, mmu_circRNA_30664) and 1 down-regulated circRNA (rno_circRNA_005568) exhibited significant validation." 1 Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated CDR1as may exert its function by regulating EGFR expression via targeting miR-7 in HCC cells. 4 Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. - hsa_circ_LARP4 circ_101057 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated CircLARP4 was mainly localized in the cytoplasm and inhibited biological behaviors of GC cells by sponging miR-424. The expression of circLARP4 was downregulated in GC tissues and represented an independent prognostic factor for overall survival of GC patients. 1 Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis. - hsa_circ_FBXW7 - DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" down-regulated "Upregulation of FBXW7-185aa in cancer cells inhibited proliferation and cell cycle acceleration, while knockdown of FBXW7-185aa promoted malignant phenotypes in vitro and in vivo." 1 Circular RNA hsa_circ_0001982 Promotes Breast Cancer Cell Carcinogenesis Through Decreasing miR-143. hsa_circ_0001982 hsa_circ_RNF111 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated Loss-of-function and rescue experiments revealed that hsa_circ_0001982 knockdown suppressed breast cancer cell proliferation and invasion and induced apoptosis by targeting miR-143. 2 Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma. hsa_circ_0004018 hsa_circ_SMYD4 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "Hsa_circ_0004018 was correlated with serum alpha-fetoprotein (AFP) level, tumor diameters, differentiation, Barcelona Clinic Liver Cancer stage and Tumor-node-metastasis stage." 3 Clinical values of circular RNA 0000181 in the screening of gastric cancer. hsa_circ_0000181 hsa_circ_TATDN3 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Hsa_circ_0000181 expression in gastric cancer tissues was significantly correlated with tumor diameter, lymphatic metastasis, distal metastasis, and carbohydrate antigen 19-9." 1 Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis. hsa_circ_0003575 hsa_circ_CHMP5 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "CircRNA microarray analysis reveals the expression profiles of HUVECs and verifies the role of hsa_circ_0003575 on HUVECs, providing a therapeutic strategy for vascular endothelial cell injury of atherosclerosis." 3 Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis. hsa_circ_0003573 hsa_circ_C11orf41 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Results showed that hsa_circ_0003573 and hsa_circ_0003204 were significantly up-regulated, while hsa_circ_0004264 and hsa_circ_0000345 were significantly down-regulated." 1 Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis. hsa_circ_0003204 hsa_circ_USP36 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Results showed that hsa_circ_0003573 and hsa_circ_0003204 were significantly up-regulated, while hsa_circ_0004264 and hsa_circ_0000345 were significantly down-regulated." 7 Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis. hsa_circ_0004264 hsa_circ_NMD3 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated "Results showed that hsa_circ_0003573 and hsa_circ_0003204 were significantly up-regulated, while hsa_circ_0004264 and hsa_circ_0000345 were significantly down-regulated." 2 Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis. hsa_circ_0000345 hsa_circ_RSF1 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated "Results showed that hsa_circ_0003573 and hsa_circ_0003204 were significantly up-regulated, while hsa_circ_0004264 and hsa_circ_0000345 were significantly down-regulated." 3 Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. hsa_circ_0089378 hsa_circ_VAV2 - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients. 1 Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. hsa_circ_0083357 hsa_circ_CTSB - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients. 1 Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. hsa_circ_0082824 hsa_circ_CUL1 - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients. 1 Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. hsa_circ_0068942 hsa_circ_ADD1 - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients. 1 Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. hsa_circ_0057576 hsa_circ_HECW2 - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients. 2 Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. hsa_circ_0054537 hsa_circ_PSME4 - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients. 1 Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. hsa_circ_0051172 hsa_circ_AXL - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients. 1 Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. hsa_circ_0032970 hsa_circ_TC2N - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients. 1 Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. hsa_circ_0006323 hsa_circ_DPYD - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients. 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_103801 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "Functional analysis found that hsa_circRNA_103801 was involved in pathways in cancer, such as the HIF-1, VEGF and angiogenesis pathway, the Rap1 signaling pathway and the PI3K-Akt signaling pathway, while hsa_circRNA_104980 was related to some pathways such as the tight junction pathway." 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_102049 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data." 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_103309 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data." 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_101113 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data." 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_102485 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data." 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_100241 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data." 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_104980 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" down-regulated "Functional analysis found that hsa_circRNA_103801 was involved in pathways in cancer, such as the HIF-1, VEGF and angiogenesis pathway, the Rap1 signaling pathway and the PI3K-Akt signaling pathway, while hsa_circRNA_104980 was related to some pathways such as the tight junction pathway." 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_104692 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" down-regulated "There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data." 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_104892 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" down-regulated "There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data." 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_102678 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" down-regulated "There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data." 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_103110 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" down-regulated "There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data." 1 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. - - hsa_circRNA_100258 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" down-regulated "There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data." 1 Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer. hsa_circ_0043256 hsa_circ_ACACA - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated "Hsa_circ_0043256 could inhibit cell proliferation and induce apoptosis, while hsa_circ_0043256 knock-down could promote cell proliferation and restrain apoptosis induced by Cinnamaldehyde (CA)." 3 Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia. hsa_circ_0075001 hsa_circ_NPM1 - DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, RNA-seq" up-regulated "Hsa_circ_0075001 expression correlates positively with total NPM1 expression, but is independent of the NPM1 mutational status. High versus low hsa_circ_0075001 expression defines patient subgroups characterized by distinct gene expression patterns, such as lower expression of components of the Toll-like receptor signaling pathway in high hsa_circ_0075001 expression cases." 1 Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. hsa_circ_0000745 hsa_circ_SPECC1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated "The expression level of hsa_circ_0000745 in GC tissues correlated with tumor differentiation, while the expression level in plasma correlated with tumor-nodemetastasis stage." 2 Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. hsa_circ_0085616 hsa_circ_ASAP1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated Hsa_circ_0085616 was reported to be up-regulated in colorectal tissues compared to that in normal tissues. 1 Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. hsa_circ_0006127 hsa_circ_SRCAP - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated Hsa_circ_0006127 (chr16:30740286-30740893) were found to be down-regulated in GC tissues compared to paired adjacent non-tumor tissues. 1 Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression. - hsa_circ_UBAP2 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated Increased circUBAP2 could promote osteosarcoma growth and inhibit apoptosis both in vitro and in vivo. Our results suggest the roles of circUBAP2 in osteosarcoma development and implicate its potential in prognosis prediction and cancer therapy. 5 "Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer." hsa_circ_0047905 hsa_circ_SERPINB5 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Functional assays suggested that inhibition of these three circular RNAs (hsa_circ_0047905, hsa_circ_0138960 and hsa-circRNA7690-15) suppresses GC cell proliferation and invasion in vitro." 2 "Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer." hsa_circ_0138960 hsa_circ_GDA - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Functional assays suggested that inhibition of these three circular RNAs (hsa_circ_0047905, hsa_circ_0138960 and hsa-circRNA7690-15) suppresses GC cell proliferation and invasion in vitro." 2 "Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer." - hsa_circ_GDA circRNA7690-15 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Functional assays suggested that inhibition of these three circular RNAs (hsa_circ_0047905, hsa_circ_0138960 and hsa-circRNA7690-15) suppresses GC cell proliferation and invasion in vitro." 2 "Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology." hsa_circ_0004712 hsa_circ_PDE7B hsa_circRNA_104194 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" up-regulated "RT-qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA." 2 "Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology." hsa_circ_0083964 hsa_circ_ASH2L hsa_circRNA_104593 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" up-regulated "RT-qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA." 3 "Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology." hsa_circ_0064996 hsa_circ_SNRK hsa_circRNA_103334 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" up-regulated "RT-qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA." 1 "Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology." hsa_circ_0032683 hsa_circ_NEK9 hsa_circRNA_101407 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" up-regulated "RT-qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA." 1 "Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology." hsa_circ_0052012 hsa_circ_POLD1 hsa_circRNA_102594 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" down-regulated "RT-qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA." 1 Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration. hsa_circ_0008305 hsa_circ_PTK2 - DOID:90 degenerative disc disease intervertebral disc degeneration RT-qPCR up-regulated "hsa_circ_0008305 upregulation and hsa_circ_0041946 downregulation were validated in IDD using reverse transcription_quantitative polymerase chain reaction. In conclusion, the findings of the present study may shed light on the potential roles of circRNAs in IDD and the possibility for their use in the diagnosis and clinical treatment of IDD in the future." 1 Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration. hsa_circ_0041946 hsa_circ_TP53 - DOID:90 degenerative disc disease intervertebral disc degeneration RT-qPCR down-regulated "hsa_circ_0008305 upregulation and hsa_circ_0041946 downregulation were validated in IDD using reverse transcription_quantitative polymerase chain reaction. In conclusion, the findings of the present study may shed light on the potential roles of circRNAs in IDD and the possibility for their use in the diagnosis and clinical treatment of IDD in the future." 1 Altered expression of circular RNAs in Moyamoya disease. - - hsa_circRNA_100914 DOID:13099 Moyamoya disease moyamoya "RT-qPCR, microarray" down-regulated "To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray (Fig. 2), confirming the reliability of the data." 1 Altered expression of circular RNAs in Moyamoya disease. - - hsa_circRNA_103343 DOID:13099 Moyamoya disease moyamoya "RT-qPCR, microarray" down-regulated "To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray (Fig. 2), confirming the reliability of the data." 1 Altered expression of circular RNAs in Moyamoya disease. - - hsa_circRNA_050898 DOID:13099 Moyamoya disease moyamoya "RT-qPCR, microarray" down-regulated "To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray (Fig. 2), confirming the reliability of the data." 1 Altered expression of circular RNAs in Moyamoya disease. - - hsa_circRNA_101720 DOID:13099 Moyamoya disease moyamoya "RT-qPCR, microarray" up-regulated "To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray (Fig. 2), confirming the reliability of the data." 1 Altered expression of circular RNAs in Moyamoya disease. - - hsa_circRNA_067209 DOID:13099 Moyamoya disease moyamoya "RT-qPCR, microarray" up-regulated "To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray (Fig. 2), confirming the reliability of the data." 1 circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis. - - has-circRNA_0046367 DOID:9452 fatty liver disease hepatic steatosis RT-qPCR down-regulated "These findings indicate a circRNA_0046367/miR-34a/PPARalpha regulatory system underlying hepatic steatosis. Normalized expression of circRNA_0046367 may ameliorate the lipoxidative stress on the basis of steatosis attenuation. circRNA_0046367, therefore, is suggested to be potential approach to the therapy of lipid peroxidative damage." 1 circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a. hsa_circ_0005239 hsa_circ_GFRA1 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated CircGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in triple negative breast cancer (TNBC). circGFRA1 may be a diagnostic biomarker and potential target for TNBC therapy. 3 Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis. - - hsa_circRNA_105055 DOID:9256 colorectal cancer colorectal cancer microarray up-regulated "It was demonstrated that hsa_circRNA_105055, hsa_circRNA_086376 and hsa_circRNA_102761 could commonly bind with miR-7 regulating target genes PRKCB, EPHA3, BRCA1 and ABCC1. The findings of the present study may provide a novel perspective on circRNA and lay a foundation for future research of potential roles of circRNA in (colorectal cancer) CRC with lung metastasis." 1 Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis. - - hsa_circRNA_086376 DOID:9256 colorectal cancer colorectal cancer microarray down-regulated "It was demonstrated that hsa_circRNA_105055, hsa_circRNA_086376 and hsa_circRNA_102761 could commonly bind with miR-7 regulating target genes PRKCB, EPHA3, BRCA1 and ABCC1. The findings of the present study may provide a novel perspective on circRNA and lay a foundation for future research of potential roles of circRNA in (colorectal cancer) CRC with lung metastasis." 1 Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis. - - hsa_circRNA_102761 DOID:9256 colorectal cancer colorectal cancer microarray down-regulated "It was demonstrated that hsa_circRNA_105055, hsa_circRNA_086376 and hsa_circRNA_102761 could commonly bind with miR-7 regulating target genes PRKCB, EPHA3, BRCA1 and ABCC1. The findings of the present study may provide a novel perspective on circRNA and lay a foundation for future research of potential roles of circRNA in (colorectal cancer) CRC with lung metastasis." 1 Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124. - hsa_circ_WDR77 - DOID:1287 cardiovascular system disease cardiovascular disease microarray up-regulated CircRNAs expression profiles in high glucose induced VSMCs and identifies the role of circWDR77-miR-124-FGF2 regulatory pathway in VSMCs proliferation and migration. 1 Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection. hsa_circ_0001785 hsa_circ_ELP3 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "Our study reveals that multiple circRNAs are closely correlated with breast cancer tumorigenesis, and thoroughly investigates the diagnostic value of hsa_circ_0001785, suggesting the promising biomarker for breast cancer detection." 3 Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection. hsa_circ_0108942 hsa_circ_ANKRD12 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "Among these circRNAs, 3 candidate circRNAs were validated to be significantly dysregulated using RT-PCR, including hsa_circ_0001785, hsa_circ_0108942 and hsa_circ_0068033." 3 Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection. hsa_circ_0068033 hsa_circ_NAALADL2 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated "Among these circRNAs, 3 candidate circRNAs were validated to be significantly dysregulated using RT-PCR, including hsa_circ_0001785, hsa_circ_0108942 and hsa_circ_0068034." 2 Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection. hsa_circ_0043497 hsa_circ_MED24 - DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" up-regulated "hsa_circ_0030045, hsa_circ_0001417 and hsa_circ_0043497 are significantly up-regulated in Mtb-infected group." 1 Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection. hsa_circ_0030045 hsa_circ_SLC25A15 - DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" up-regulated "hsa_circ_0030045, hsa_circ_0001417 and hsa_circ_0043497 are significantly up-regulated in Mtb-infected group." 1 Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection. hsa_circ_0001417 hsa_circ_ANKRD17 - DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" up-regulated "hsa_circ_0030045, hsa_circ_0001417 and hsa_circ_0043497 are significantly up-regulated in Mtb-infected group." 1 Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection. hsa_circ_0030569 hsa_circ_ABCC4 - DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" down-regulated hsa_circ_0030569 and hsa_circ_0001204 are significantly down-regulated in Mtb-infected group. 1 Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection. hsa_circ_0001204 hsa_circ_DGCR8 - DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" down-regulated hsa_circ_0030569 and hsa_circ_0001204 are significantly down-regulated in Mtb-infected group. 3 Circular RNA profile of infantile hemangioma by microarray analysis. hsa_circ_0023984 hsa_circ_NOX4 - DOID:255 hemangioma infantile hemangioma "RT-qPCR, microarray" up-regulated This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH. 1 Circular RNA profile of infantile hemangioma by microarray analysis. hsa_circ_0003570 hsa_circ_FAM53B - DOID:255 hemangioma infantile hemangioma "RT-qPCR, microarray" up-regulated This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH. 1 Circular RNA profile of infantile hemangioma by microarray analysis. hsa_circ_0079385 hsa_circ_ZDHHC4 - DOID:255 hemangioma infantile hemangioma "RT-qPCR, microarray" down-regulated This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH. 1 Circular RNA profile of infantile hemangioma by microarray analysis. hsa_circ_0003258 hsa_circ_ZNF652 - DOID:255 hemangioma infantile hemangioma "RT-qPCR, microarray" up-regulated This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH. 1 Circular RNA profile of infantile hemangioma by microarray analysis. hsa_circ_0051239 hsa_circ_ATP5SL - DOID:255 hemangioma infantile hemangioma "RT-qPCR, microarray" up-regulated This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH. 1 Circular RNA profile of infantile hemangioma by microarray analysis. hsa_circ_0043138 hsa_circ_TAF15 - DOID:255 hemangioma infantile hemangioma "RT-qPCR, microarray" up-regulated This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH. 1 Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. hsa_circ_0001017 hsa_circ_XPO1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "We found that hsa_circ_0001017 and hsa_circ_0061276 both decreased in gastric cancer tissues and patients plasma. Moreover, their levels were tightly associated with main clinicopathological features of patients with gastric cancer. As a result, hsa_circ_0001017 and hsa_circ_0061276 may be valuable blood-based biomarkers, either alone or in combination, to screen gastric cancer and estimate prognosis." 1 Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. hsa_circ_0061276 hsa_circ_NRIP1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "We found that hsa_circ_0001017 and hsa_circ_0061276 both decreased in gastric cancer tissues and patients plasma. Moreover, their levels were tightly associated with main clinicopathological features of patients with gastric cancer. As a result, hsa_circ_0001017 and hsa_circ_0061276 may be valuable blood-based biomarkers, either alone or in combination, to screen gastric cancer and estimate prognosis." 6 "Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma." hsa_circ_0000520 hsa_circ_RPPH1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated We first identified that hsa_circ_0000520 was significantly down-regulated in gastric cancer. Our study indicated hsa_circ_0000520 might serve as a novel biomarker for gastric cancer and is involved in gastric carcinoma development. 2 Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity. - hsa_circ_DLGAP4 - DOID:2316 brain ischemia acute ischemic injury RT-qPCR down-regulated Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity. 2 Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma. hsa_circ_0009910 - circ_0009910 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "we suggested that circ_0009910 acted as a sponge of miR-449a and upregulated miR-449a functional target IL6R, thereby contributed to carcinogenesis of OS." 1 The expression profile and clinical significance of circRNA0003906 in colorectal cancer. hsa_circ_0003906 hsa_circ_None circRNA0003906 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated CircRNA0003906 may be potentially involved in the colorectal cancerogenesis and serve as a potential biomarker for the diagnosis and treatment of CRC. 1 Circular RNA hsa_circ_0003221 (circPTK2) promotes the proliferation and migration of bladder cancer cells. hsa_circ_0003221 hsa_circ_PTK2 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated "In vitro silence of circPTK2 by small interfering RNA inhibited the proliferation and migration of bladder cancer cells. On the contrary, circPTK2 overexpression promoted proliferation and migration." 4 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. - - hsa_circRNA_070616 DOID:1677 low implantation of placenta repeated implantation failure "RT-qPCR, microarray" up-regulated "The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR." 1 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. - - hsa_circRNA_103716 DOID:1677 low implantation of placenta repeated implantation failure "RT-qPCR, microarray" up-regulated "The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR." 1 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. - - hsa_circRNA_104001 DOID:1677 low implantation of placenta repeated implantation failure "RT-qPCR, microarray" up-regulated "The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR." 1 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. - - hsa_circRNA_104854 DOID:1677 low implantation of placenta repeated implantation failure "RT-qPCR, microarray" up-regulated "The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR." 1 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. - - hsa_circRNA_004183 DOID:1677 low implantation of placenta repeated implantation failure "RT-qPCR, microarray" down-regulated "The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR." 1 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. - - hsa_circRNA_044353 DOID:1677 low implantation of placenta repeated implantation failure "RT-qPCR, microarray" down-regulated "The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR." 1 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. - - hsa_circRNA_404686 DOID:1677 low implantation of placenta repeated implantation failure "RT-qPCR, microarray" down-regulated "The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR." 1 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. hsa_circ_0004372 hsa_circ_PAN3 - DOID:0080685 aortic dissection thoracic aortic dissection "RT-qPCR, microarray" up-regulated "The luciferase reporter was constructed to determine whether hsa_circRNA_101238 can directly target the hsa-miR-320a. The luciferase signal of hsa-miR-320a was suppressed by the wild-type hsa_circRNA_101238, whereas the luciferase signal of hsa-miR-320a was not affected by the mutant hsa_circRNA_101238. Quantitative real-time PCR and Western blot manifested the low expression of hsa-miR-320a and high of MMP9 in human TAD tissues, respectively." 1 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. hsa_circ_0084615 hsa_circ_ASPH - DOID:0080685 aortic dissection thoracic aortic dissection "RT-qPCR, microarray" up-regulated "The upregulated hsa_circRNA_104634 and hsa_circRNA_104349 interacted with hsa-miR-145-3p and hsa-miR-26a-3p, respectively that have been demonstrated to increase SMC phenotype or apoptosis." 1 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. hsa_circ_0002271 hsa_circ_C2orf43 - DOID:0080685 aortic dissection thoracic aortic dissection "RT-qPCR, microarray" up-regulated Upregulated significantly in human TAD as compared to NA. 1 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. hsa_circ_0055377 hsa_circ_CTNNA2 - DOID:0080685 aortic dissection thoracic aortic dissection "RT-qPCR, microarray" up-regulated Upregulated significantly in human TAD as compared to NA. 1 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. hsa_circ_0079929 hsa_circ_CDK13 - DOID:0080685 aortic dissection thoracic aortic dissection "RT-qPCR, microarray" up-regulated "The upregulated hsa_circRNA_104634 and hsa_circRNA_104349 interacted with hsa-miR-145-3p and hsa-miR-26a-3p, respectively that have been demonstrated to increase SMC phenotype or apoptosis." 1 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. hsa_circ_0007386 hsa_circ_CRIM1 - DOID:0080685 aortic dissection thoracic aortic dissection "RT-qPCR, microarray" down-regulated "The downregulated hsa_circRNA_102683 and hsa_circRNA_104033 inhibited hsa-miR-29b-1-5p and hsa-miR-195-3p, respectively, which has been shown to target the aortic wall apoptosis and ECM degradation or stimulation of the collagen remodeling." 1 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. hsa_circ_0005525 hsa_circ_ATP8B1 - DOID:0080685 aortic dissection thoracic aortic dissection "RT-qPCR, microarray" down-regulated Downregulated significantly in human TAD as compared to NA. 1 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. hsa_circ_0067175 hsa_circ_ABTB1 - DOID:0080685 aortic dissection thoracic aortic dissection "RT-qPCR, microarray" down-regulated Downregulated significantly in human TAD as compared to NA. 1 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. hsa_circ_0085154 hsa_circ_PABPC1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray down-regulated "we found CircARSP91 (hsa_circ_0085154), one of the circRNAs downregulated by AR in an ADAR1-dependent manner, could inhibit HCC tumor growth both in vitro and in vivo. " 2 Identification of circular RNA signature in bladder cancer. hsa_circ_0091017 hsa_circ_TAF1 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "The expression level changes of hsa_circ_0091017 and hsa_circ_0002024 in the 32 paired samples were in accord with NGS data. In conclusion, we identified a set of circRNAs that are potentially implicated in the tumorigenesis of BCa (bladder cancer) and could serve as novel diagnostic markers for BCa." 2 Identification of circular RNA signature in bladder cancer. hsa_circ_0092024 hsa_circ_FLNA - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "The expression level changes of hsa_circ_0091017 and hsa_circ_0002024 in the 32 paired samples were in accord with NGS data. In conclusion, we identified a set of circRNAs that are potentially implicated in the tumorigenesis of BCa (bladder cancer) and could serve as novel diagnostic markers for BCa." 2 Screening circular RNA expression patterns following focal cerebral ischemia in mice. - - mmu_circRNA_40001 DOID:6713 cerebrovascular disease ischemic brain after stroke "RT-qPCR, microarray" up-regulated "we constructed an interaction network of circRNA-miRNA-target genes, including 13 miRNAs and their corresponding genes, indicating that changes in circRNA are associated with genes related with brain injury and recovery. In conclusion, circRNAs are complicated in the pathological development of brain injury after stroke, suggesting novel diagnostic and therapeutic targets for stroke therapy." 1 Screening circular RNA expression patterns following focal cerebral ischemia in mice. - - mmu_circRNA_013120 DOID:6713 cerebrovascular disease ischemic brain after stroke "RT-qPCR, microarray" up-regulated "we constructed an interaction network of circRNA-miRNA-target genes, including 14 miRNAs and their corresponding genes, indicating that changes in circRNA are associated with genes related with brain injury and recovery. In conclusion, circRNAs are complicated in the pathological development of brain injury after stroke, suggesting novel diagnostic and therapeutic targets for stroke therapy." 1 Screening circular RNA expression patterns following focal cerebral ischemia in mice. - - mmu_circRNA_40806 DOID:6713 cerebrovascular disease ischemic brain after stroke "RT-qPCR, microarray" down-regulated "we constructed an interaction network of circRNA-miRNA-target genes, including 15 miRNAs and their corresponding genes, indicating that changes in circRNA are associated with genes related with brain injury and recovery. In conclusion, circRNAs are complicated in the pathological development of brain injury after stroke, suggesting novel diagnostic and therapeutic targets for stroke therapy." 1 Circular RNA expression profiles reveal that hsa_circ_0018289 is up-regulated in cervical cancer and promotes the tumorigenesis. hsa_circ_0018289 hsa_circ_SYT15 - DOID:4362 cervical cancer cervical cancer microarray up-regulated "Hsa_circ_0018289 plays important role in cervical cancer proliferation, migration and invasion, suggesting the miRNA sponge of hsa_circ_0018289 and its oncogenic role on cervical cancer tumorigenesis." 3 The circular RNA MICRA for risk stratification after myocardial infarction. - - MICRA DOID:5844 myocardial infarction myocardial Infarction RT-qPCR down-regulated we show that MICRA provides an incremental value to risk stratify patients after MI. Further prospective studies are warranted to confirm this predictive value and the clinical usefulness of this finding. 2 Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients. - - hsa_circ_402458 DOID:12236 primary biliary cholangitis primary biliary cirrhosis RT-qPCR up-regulated "Our results indicated that there were 18 up-regulated and 4 down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals. Among the differentially expressed circRNAs, hsa_circ_402458 (P=0.0033), hsa_circ_087631 and hsa_circ_406329 (P=0.0185) were up-regulated, and hsa_circ_407176 (P=0.0066) and hsa_circ_082319 were down-regulated in the PBC group versus the healthy group as demonstrated by qRT-PCR." 1 Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients. - - hsa_circ_087631 DOID:12236 primary biliary cholangitis primary biliary cirrhosis RT-qPCR up-regulated "Our results indicated that there were 18 up-regulated and 4 down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals. Among the differentially expressed circRNAs, hsa_circ_402458 (P=0.0033), hsa_circ_087631 and hsa_circ_406329 (P=0.0185) were up-regulated, and hsa_circ_407176 (P=0.0066) and hsa_circ_082320 were down-regulated in the PBC group versus the healthy group as demonstrated by qRT-PCR." 1 Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients. - - hsa_circ_406329 DOID:12236 primary biliary cholangitis primary biliary cirrhosis RT-qPCR up-regulated "Our results indicated that there were 18 up-regulated and 4 down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals. Among the differentially expressed circRNAs, hsa_circ_402458 (P=0.0033), hsa_circ_087631 and hsa_circ_406329 (P=0.0185) were up-regulated, and hsa_circ_407176 (P=0.0066) and hsa_circ_082321 were down-regulated in the PBC group versus the healthy group as demonstrated by qRT-PCR." 1 Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients. - - hsa_circ_407176 DOID:12236 primary biliary cholangitis primary biliary cirrhosis RT-qPCR down-regulated "Our results indicated that there were 18 up-regulated and 4 down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals. Among the differentially expressed circRNAs, hsa_circ_402458 (P=0.0033), hsa_circ_087631 and hsa_circ_406329 (P=0.0185) were up-regulated, and hsa_circ_407176 (P=0.0066) and hsa_circ_082322 were down-regulated in the PBC group versus the healthy group as demonstrated by qRT-PCR." 1 Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients. - - hsa_circ_082319 DOID:12236 primary biliary cholangitis primary biliary cirrhosis RT-qPCR down-regulated "Our results indicated that there were 18 up-regulated and 4 down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals. Among the differentially expressed circRNAs, hsa_circ_402458 (P=0.0033), hsa_circ_087631 and hsa_circ_406329 (P=0.0185) were up-regulated, and hsa_circ_407176 (P=0.0066) and hsa_circ_082323 were down-regulated in the PBC group versus the healthy group as demonstrated by qRT-PCR." 1 Crosstalk in competing endogenous RNA network reveals the complex molecular mechanism underlying lung cancer. - - circRNA4046 DOID:1324 lung cancer lung cancer RNA-seq down-regulated "Three circRNAs (circRNA4046, circRNA4882, and circRNA4406) were included in the TF regulatory network as miRNA targets." 1 Crosstalk in competing endogenous RNA network reveals the complex molecular mechanism underlying lung cancer. - - circRNA4406 DOID:1324 lung cancer lung cancer RNA-seq down-regulated "Three circRNAs (circRNA4046, circRNA4882, and circRNA4406) were included in the TF regulatory network as miRNA targets." 1 Crosstalk in competing endogenous RNA network reveals the complex molecular mechanism underlying lung cancer. - - circRNA4882 DOID:1324 lung cancer lung cancer RNA-seq down-regulated "Three circRNAs (circRNA4046, circRNA4882, and circRNA4406) were included in the TF regulatory network as miRNA targets." 1 Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b. hsa_circ_0001724 hsa_circ_CDK6 hsa_circ_000984 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Further analysis revealed that hsa_circ_000984 knockdown could inhibit cell proliferation, migration, invasion in vitro and tumor formation in vivo in colorectal cancer (CRC) cell lines. Mechanically, we found that hsa_circ_000984 may act as a competing endogenous RNA (ceRNA) by competitively binding miR-106b and effectively upregulate the expression of CDK6, thereby inducing a series of malignant phenotypes of tumor cells." 1 Genome-Wide Search for Competing Endogenous RNAs Responsible for the Effects Induced by Ebola Virus Replication and Transcription Using a trVLP System. - - circRNA-chr19 DOID:4325 Ebola hemorrhagic fever ebola virus disease RNA-seq up-regulated CircRNA-chr19 targeting miR-30b-3p regulated CLDN18 expression by functioning as a ceRNA. 1 CircLRP6 Regulation of ZEB1 via miR-455 Is Involved in the Epithelial-Mesenchymal Transition During Arsenite-Induced Malignant Transformation of Human Keratinocytes. - hsa_circ_LRP6 - DOID:162 cancer cancer RNA-seq up-regulated "Thus, for HaCaT cells chronically exposed to arsenite, circLRP6 via miR-455 regulation of ZEB1 is involved in the EMT during malignant transformation. The results establish a previously unknown mechanism for arsenite-induced carcinogenesis." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA120 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 32 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA167 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 33 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA2918 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 34 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA3341 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 35 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA3594 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 36 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA3703 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 37 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA3706 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 38 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA3707 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 39 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA378 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 40 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA4628 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 41 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA5669 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 42 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA666 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 43 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA7534 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 44 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA7535 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 45 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA7536 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 46 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA7537 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 47 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA7673 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 48 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA7674 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 49 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA7675 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 50 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA7676 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 51 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA7679 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 52 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA8505 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 53 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA8506 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 54 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA8507 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 55 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA904 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 56 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA9227 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 57 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA9652 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 58 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA9656 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 59 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA9658 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 60 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA9671 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 61 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA9771 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 62 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. - - circRNA9777 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 63 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells." 1 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. - hsa_circ_VRK1 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK1 might be a promising target for BCSCs." 2 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. - hsa_circ_BRIP - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK2 might be a promising target for BCSCs." 1 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. - hsa_circ_OLA - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK3 might be a promising target for BCSCs." 1 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. - hsa_circ_ETFA - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK4 might be a promising target for BCSCs." 1 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. - hsa_circ_MED13 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK5 might be a promising target for BCSCs." 1 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. - hsa_circ_BCL11B - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK6 might be a promising target for BCSCs." 1 Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer. hsa_circ_0000064 hsa_circ_B4GALT2 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "Western blot analysis showed that the protein levels of caspase-3, caspase-9, bax, p21, CDK6 and cyclin D1 significantly restrained by si-hsa_circ_0000064, while the expression of bcl-2 notably increased in A549 and H1229 cells. Further, si-hsa_circ_0000064 also abated migration and invasion activities of A549 and H1229 cells, which may be associated with reduced expressions of MMP-2 and MMP-9. In general, our data suggest that hsa_circ_0000064 represents a novel potential biomarker and therapeutic target of lung cancer." 1 Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. hsa_circ_0001564 hsa_circ_CANX - DOID:3347 osteosarcoma osteosarcoma microarray up-regulated "Our study discovers that hsa_circ_0001564 acts as miR-29c-3p sponge to mediate the tumorigenicity, which could act as a potential biomarker for the osteosarcoma and provide a novel insight for competing endogenous RNAs (ceRNAs) mechanism in osteosarcoma." 1 Downregulated expression of hsa_circ_0074362 in gastric cancer and its potential diagnostic values. hsa_circ_0074362 hsa_circ_ARHGAP26 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Hsa_circ_0074362 probably plays a role in the initiation of gastric cancer and may be a potential biomarker of gastric cancer. 3 CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients. - - hsa_circRNA_404833 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq, microarray" up-regulated "This work illustrates that clusters of circRNAs are aberrantly expressed in early-stage lung adenocarcinoma, which might offer potential targets for the early diagnosis of this disease and new genetic insights into lung cancer." 1 CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients. - - hsa_circRNA_006411 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq, microarray" down-regulated "This work illustrates that clusters of circRNAs are aberrantly expressed in early-stage lung adenocarcinoma, which might offer potential targets for the early diagnosis of this disease and new genetic insights into lung cancer." 1 CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients. - - hsa_circRNA_401977 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq, microarray" down-regulated "This work illustrates that clusters of circRNAs are aberrantly expressed in early-stage lung adenocarcinoma, which might offer potential targets for the early diagnosis of this disease and new genetic insights into lung cancer." 1 Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis. - - mmu-circRNA-30365 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" down-regulated "Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis." 1 Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis. - - mmu-circRNA-33736 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" down-regulated "Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis." 1 Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis. - - mmu-circRNA-2483 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" down-regulated "Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis." 1 Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis. - - mmu-circRNA-36866 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" up-regulated "Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis." 1 Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis. - - mmu-circRNA-33186 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" up-regulated "Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis." 1 Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis. - - mmu-circRNA-2443 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" up-regulated "Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis." 1 Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis. - - mmu-circRNA-7063 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" up-regulated "Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis." 1 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. hsa_circ_0000681 hsa_circ_PRKCB - DOID:2957 pulmonary tuberculosis pulmonary tuberculosis "RT-qPCR, RNA-seq, microarray" up-regulated "we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management." 1 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. hsa_circ_0008797 hsa_circ_GSK3B - DOID:2957 pulmonary tuberculosis pulmonary tuberculosis "RT-qPCR, RNA-seq, microarray" up-regulated "we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management." 1 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. hsa_circ_0002113 hsa_circ_IFNGR2 - DOID:2957 pulmonary tuberculosis pulmonary tuberculosis "RT-qPCR, RNA-seq, microarray" up-regulated "we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management." 1 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. hsa_circ_0002362 hsa_circ_ASAP2 - DOID:2957 pulmonary tuberculosis pulmonary tuberculosis "RT-qPCR, RNA-seq, microarray" up-regulated "we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management." 1 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. hsa_circ_0000414 hsa_circ_IRAK3 - DOID:2957 pulmonary tuberculosis pulmonary tuberculosis "RT-qPCR, RNA-seq, microarray" up-regulated "we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management." 1 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. hsa_circ_0063179 hsa_circ_CSF2RB - DOID:2957 pulmonary tuberculosis pulmonary tuberculosis "RT-qPCR, RNA-seq, microarray" up-regulated "we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management." 1 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. hsa_circ_0002908 hsa_circ_PTK2 - DOID:2957 pulmonary tuberculosis pulmonary tuberculosis "RT-qPCR, RNA-seq, microarray" up-regulated "we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management." 1 "CD90 promotes cell migration, viability and sphere_forming ability of hepatocellular carcinoma cells." hsa_circ_0067531 hsa_circ_PIK3CB - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated hsa_circ_0067531 may affect the biological functions of CD90+ HCC cells and may be a promising candidate to aid in the diagnosis and therapy of HCC. 1 CircRNA_100782 regulates pancreatic carcinoma proliferation through the IL6-STAT3 pathway. - - circRNA_100782 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated these results suggest that circRNA_100782 regulates BxPC3 cell proliferation by acting as miR-124 sponge through the IL6-STAT3 pathway. 1 Overexpression of CircRNA BCRC4 regulates cell apoptosis and MicroRNA-101/EZH2 signaling in bladder cancer. - hsa_circ_BCRC4 circ_RNA BCRC4 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "our findings suggest that BCRC4 functions as a tumor suppressor in BC, and mediates anticancer function, at least in part, by up-regulating the expression of miR-101. Targeting this newly identified circRNA may help us develop a novel strategy for treating human BC." 1 [Effect of Circular RNA UBAP2 Silencing on Proliferation and Invasion of Human Lung Cancer A549 Cells and Its Mechanism]. - hsa_circ_UBAP2 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "We also found that after circUBAP2 silencing, cell invasion of A549 cells was significantly inhibited. Western blot and Real-time PCR results showed that expression of CDK6, cyclin D1, c-IAP1, Bcl-2, Survivin, FAK, Rac1 and MMP2 were down-regulated, and the expression of p27 and Bax were up-regulated. Moreover, the activities of JNK and ERK1/2 were inhibited because of circUBAP2 silencing, the target genes were miR-339-5p, miR-96-3p and miR-135b-3p." 1 CircDOCK1 suppresses cell apoptosis via inhibition of miR_196a_5p by targeting BIRC3 in OSCC. - hsa_circ_DOCK1 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "Our results demonstrated that circDOCK1 regulated BIRC3 expression by functioning as a competing endogenous RNA(ceRNA) and participated in the process of OSCC apoptosis. Thus, we propose that circDOCK1 could represent a novel potential biomarker and therapeutic target of OSCC." 1 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0005015 hsa_circ_HAS2 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 1 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0000615 hsa_circ_ZNF609 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 2 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0019069 hsa_circ_SLC16A12 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 1 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0066922 hsa_circ_HGD - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 1 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0081108 hsa_circ_COL1A2 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 4 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0081162 hsa_circ_COL1A2 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 4 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0087206 hsa_circ_ALDH1A1 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 1 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0087215 hsa_circ_ANXA1 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 1 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0041796 hsa_circ_C17orf81 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" down-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 2 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0072410 hsa_circ_NNT - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" down-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 2 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0026388 hsa_circ_KRT75 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" down-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 1 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0057093 hsa_circ_PDK1 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" down-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 1 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0030055 hsa_circ_MTRF1 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" down-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 1 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0026372 hsa_circ_KRT81 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" down-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 1 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. hsa_circ_0068489 hsa_circ_MASP1 - DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" down-regulated "CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis." 1 circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination. - hsa_circ_HECTD1 - DOID:10325 silicosis silicosis "RT-qPCR, microarray" down-regulated "Our study elucidated a link between SiO2-induced macrophage activation and the circHECTD1/HECTD1 pathway, thereby providing new insight into the potential use of HECTD1 in the development of novel therapeutic strategies for treating silicosis." 1 Circular RNA hsa_circ_0021001 in peripheral blood: a potential novel biomarker in the screening of intracranial aneurysm. hsa_circ_0021001 hsa_circ_ARFIP2 - DOID:10941 intracranial aneurysm intracranial aneurysm RT-qPCR down-regulated "We found for the first time that hsa_circ_0021001 decreased significantly in the peripheral blood of IA patients, which suggested that hsa_circ_0021001 might be used as a potential novel marker for the diagnosis of IA." 1 "Circular RNA Atp9b, a competing endogenous RNA, regulates the progression of osteoarthritis by targeting miR-138-5p." - mmu_circ_Atp9b - DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Taken together, these results suggest that circRNA_Atp9b regulates OA progression by modulating ECM catabolism and inflammation in chondrocytes via sponging miR-138-5p. Our findings provide novel insight into the regulatory mechanism of circRNA_Atp9b in OA and may contribute to establishing potential therapeutic strategies." 1 Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer. - hsa_circ_LDLRAD3 - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "Circ-LDLRAD3 was up-regulated in pancreatic cancer cell lines (P < 0.01), pancreatic cancer tissues (P < 0.01), and plasma samples from patients with pancreatic cancer (P < 0.01). High expression of circ-LDLRAD3 was significantly associated with venous invasion, lymphatic invasion, and metastasis. The area under the ROC curve of circ-LDLRAD3 alone or combination with CA19-9 was 0.67 and 0.87, respectively, with a sensitivity and specificity of 0.5738 (alone) and 0.7049 (alone), and 0.8033 (combination) and 0.9355 (combination), respectively." 2 Circular RNA hsa_circ_0000567 can be used as a promising diagnostic biomarker for human colorectal cancer. hsa_circ_0000567 hsa_circ_SETD3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated Hsa_circ_0000567 may be a novel suppressor and a potential diagnosis biomarker in CRC. 2 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. hsa_circ_0109046 hsa_circ_ZNF700 - DOID:1380 endometrial cancer endometrial cancer "RT-qPCR, RNA-seq" up-regulated We identified 275 differentially expressed circRNAs and the expression level of two circRNAs was confirmed using real-time quantitative PCR. 2 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. hsa_circ_0002577 hsa_circ_WDR26 - DOID:1380 endometrial cancer endometrial cancer "RT-qPCR, RNA-seq" up-regulated We identified 275 differentially expressed circRNAs and the expression level of two circRNAs was confirmed using real-time quantitative PCR. 4 Circular RNA expression in ovarian endometriosis. hsa_circ_0062557 hsa_circ_CHCHD10 - DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" up-regulated "The circRNA 0062557 and circRNA 0026143 were overexpressed in EC, consistent with the data from microarray; however, there is no statistical significance. The data confirmed that circRNA 0023115 and circRNA 0000673 were significantly lower expressed, with 5.7-and 1.7 fold change downregulated in EC compared with EU (p < 0.05)." 1 Circular RNA expression in ovarian endometriosis. hsa_circ_0026143 hsa_circ_TROAP - DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" up-regulated "The circRNA 0062557 and circRNA 0026143 were overexpressed in EC, consistent with the data from microarray; however, there is no statistical significance. The data confirmed that circRNA 0023115 and circRNA 0000673 were significantly lower expressed, with 5.7-and 1.7 fold change downregulated in EC compared with EU (p < 0.05)." 1 Circular RNA expression in ovarian endometriosis. hsa_circ_0023115 hsa_circ_GSTP1 - DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" down-regulated "The circRNA 0062557 and circRNA 0026143 were overexpressed in EC, consistent with the data from microarray; however, there is no statistical significance. The data confirmed that circRNA 0023115 and circRNA 0000673 were significantly lower expressed, with 5.7-and 1.7 fold change downregulated in EC compared with EU (p < 0.05)." 1 Circular RNA expression in ovarian endometriosis. hsa_circ_0000673 hsa_circ_RSL1D1 - DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" down-regulated "The circRNA 0062557 and circRNA 0026143 were overexpressed in EC, consistent with the data from microarray; however, there is no statistical significance. The data confirmed that circRNA 0023115 and circRNA 0000673 were significantly lower expressed, with 5.7-and 1.7 fold change downregulated in EC compared with EU (p < 0.05)." 1 "A novel circular RNA, hsa_circ_0046701, promotes carcinogenesis by increasing the expression of miR-142-3p target ITGB8 in glioma." hsa_circ_0046701 hsa_circ_YES1 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated The results demonstrated that the hsa_circ_0046701/miR-142-3p/ITGB8 axis might play critical regulatory roles in the pathogenesis and development of glioma. 1 "Downregulated circular RNA hsa_circ_0001649 regulates proliferation, migration and invasion in cholangiocarcinoma cells." hsa_circ_0001649 hsa_circ_SHPRH - DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR down-regulated "Furthermore, tumor xenograft study confirmed the in_itro results. Collectively, our findings suggest that hsa_circ_0001649 might be a rational CCA-related therapeutic target." 1 Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein. - hsa_circ_VMA21 - DOID:90 degenerative disc disease intervertebral disc degeneration RT-qPCR down-regulated CircVMA21 could alleviate inflammatory cytokines-induced NP cell apoptosis and imbalance between anabolism and catabolism of extracellular matrix through miR-200c-XIAP pathway. It provides a potentially effective therapeutic strategy for IVDD. 1 A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. - hsa_circ_SHPRH circ-SHPRH DOID:0060108 brain glioma glioma RT-qPCR down-regulated "Our findings provide a novel perspective regarding circRNA function in physiological and pathological processes. Specifically, SHPRH-146aa generated from overlapping genetic codes of circ-SHPRH is a tumor suppressor in human glioblastoma." 2 Circular RNA Expression Profiles Alter Significantly after Traumatic Brain Injury in Rats. - - rno_circRNA_006508 DOID:81292 traumatic brain injury traumatic brain injury microarray up-regulated "The circRNAs rno_circRNA_006508 and rno_circRNA_010705 were observed to be upregulated, and rno_circRNA_001167 and rno_circRNA_001168 were observed to be downregulated significantly after TBI." 1 Circular RNA Expression Profiles Alter Significantly after Traumatic Brain Injury in Rats. - - rno_circRNA_010705 DOID:81292 traumatic brain injury traumatic brain injury microarray up-regulated "The circRNAs rno_circRNA_006508 and rno_circRNA_010705 were observed to be upregulated, and rno_circRNA_001167 and rno_circRNA_001168 were observed to be downregulated significantly after TBI." 1 Circular RNA Expression Profiles Alter Significantly after Traumatic Brain Injury in Rats. - - rno_circRNA_001167 DOID:81292 traumatic brain injury traumatic brain injury microarray down-regulated "The circRNAs rno_circRNA_006508 and rno_circRNA_010705 were observed to be upregulated, and rno_circRNA_001167 and rno_circRNA_001168 were observed to be downregulated significantly after TBI." 1 Circular RNA Expression Profiles Alter Significantly after Traumatic Brain Injury in Rats. - - rno_circRNA_001168 DOID:81292 traumatic brain injury traumatic brain injury microarray down-regulated "The circRNAs rno_circRNA_006508 and rno_circRNA_010705 were observed to be upregulated, and rno_circRNA_001167 and rno_circRNA_001168 were observed to be downregulated significantly after TBI." 1 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. hsa_circ_0092374 hsa_circ_GADD45A - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future. 1 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. hsa_circ_0003146 hsa_circ_EHD2 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future. 1 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. hsa_circ_0034398 hsa_circ_C15orf41 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future. 1 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. hsa_circ_0001866 hsa_circ_UBQLN1 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future. 1 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. hsa_circ_0008615 hsa_circ_PPP1R13L - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future. 1 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. hsa_circ_0046599 hsa_circ_B3GNTL1 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" down-regulated we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future. 1 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. hsa_circ_0021549 hsa_circ_MPPED2 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" down-regulated we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future. 1 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. hsa_circ_0040705 hsa_circ_USP10 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" down-regulated we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future. 1 Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN. - hsa_circ_ZFR - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "Circ-ZFR restrained GC cell proliferation, induced cell cycle arrest and promoted apoptosis by sponging miR-130a/miR-107 and regulating PTEN." 1 "Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson Disease." - cel_circ_zip-2 circzip-2 DOID:14330 Parkinson disease Parkinson disease RT-qPCR down-regulated Further interaction studies revealed that circzip-2 possibly sponges microRNA molecule miR-60 towards asserting an important role in various processes associated with PD. 1 Silencing of hsa_circ_0007534 suppresses proliferation and induces apoptosis in colorectal cancer cells. hsa_circ_0007534 hsa_circ_DDX42 - DOID:9256 colorectal cancer colorectal cancer microarray up-regulated Hsa_circ_0007534 plays a crucial role in the initiation and progression of CRC and may be a potential therapeutic target of CRC. 3 Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation. hsa_circ_0012673 hsa_circ_DHCR24 - DOID:1324 lung cancer lung cancer microarray up-regulated "Furthermore, hsa_circ_0012673 was primarily localized in the cytoplasm and promoted cell proliferation of LAC cells by sponging miR-22, which targeted erb-b2 receptor tyrosine kinase 3 (ErbB3) in LAC. Hsa_circ_0012673 promotes LAC proliferation by suppressing miR-22, which targets ErbB3." 2 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. - - circRNA_14623 DOID:2957 pulmonary tuberculosis pulmonary tuberculosis RNA-seq up-regulated "hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB." 1 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. - - circRNA_09585 DOID:2957 pulmonary tuberculosis pulmonary tuberculosis RNA-seq up-regulated "hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB." 1 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. - - circRNA_05538 DOID:2957 pulmonary tuberculosis pulmonary tuberculosis RNA-seq down-regulated "hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB." 1 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. - - circRNA_09993 DOID:2957 pulmonary tuberculosis pulmonary tuberculosis RNA-seq down-regulated "hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB." 1 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. - - circRNA_13478 DOID:2957 pulmonary tuberculosis pulmonary tuberculosis RNA-seq down-regulated "hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB." 1 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. - - circRNA_00074 DOID:2957 pulmonary tuberculosis pulmonary tuberculosis RNA-seq up-regulated "hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB." 1 Microarray profiles reveal that circular RNA hsa_circ_0007385 functions as an oncogene in non-small cell lung cancer tumorigenesis. hsa_circ_0007385 hsa_circ_MEMO1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated "In summary, results suggest hsa_circ_0007385 plays a role in NSCLC tumorigenesis, providing a potential therapeutic target for NSCLC." 5 Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. hsa_circ_0001445 hsa_circ_SMARCA5 cSMARCA5 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated "Herein, we studied the role of cSMARCA5, a circular RNA, in hepatocellular carcinoma. Our in vitro and in vivo data showed that cSMARCA5 inhibits the growth and migration of hepatocellular carcinoma cells, making it a potential therapeutic target." 3 Circular RNA circ-NT5C2 acts as an oncogene in osteosarcoma proliferation and metastasis through targeting miR-448. - hsa_circ_NT5C2 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "our study investigates the circRNAs expression profiles and determines the function of circ-NT5C2 in osteosarcoma tumorigenesis, which might serve as a novel therapeutic target of osteosarcoma patients." 2 "Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression." - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "Circ-ITCH acts as a tumor suppressor by a novel circ-ITCH/miR-17, miR-224/p21, PTEN axis, which may provide a potential biomarker and therapeutic target for the management of BCa." 1 circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling. - - circRNA_0046366 DOID:9452 fatty liver disease hepatocellular steatosis RT-qPCR down-regulated Dysregulation of circRNA_0046366/miR-34a/PPARalpha signaling may be a novel epigenetic mechanism underlying hepatocellular steatosis. circRNA_0046366 serves as a potential target for the treatment of hepatic steatosis. 1 Circular RNAs as novel regulators of beta-cell functions in normal and disease conditions. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:9351 diabetes mellitus diabetes microarray down-regulated Our findings point to circular RNAs as novel regulators of beta-cell activities and suggest an involvement of this novel class of non-coding RNAs in beta-cell dysfunction under diabetic conditions. 2 Circular RNAs as novel regulators of beta-cell functions in normal and disease conditions. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:9351 diabetes mellitus diabetes microarray down-regulated Our findings point to circular RNAs as novel regulators of beta-cell activities and suggest an involvement of this novel class of non-coding RNAs in beta-cell dysfunction under diabetic conditions. 1 Silica-induced initiation of circular ZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation. - hsa_circ_ZC3H4 - DOID:10325 silicosis silicosis RT-qPCR up-regulated "Our study elucidates a link between SiO2-induced macrophage activationand the circZC3H4 RNA/ZC3H4 pathway, thereby providing novel insight into the potentialuse of ZC3H4 to develop novel therapeutic strategies for silicosis." 2 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. - - circ_0015756 DOID:687 hepatoblastoma hepatoblastoma microarray up-regulated "CircRNAs are involved in the pathogenesis of hepatoblastoma. circ_0015756 is a promising target for the prognosis, diagnosis, and treatment of hepatoblastoma." 1 CircSMARCA5 Inhibits Migration of Glioblastoma Multiforme Cells by Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB. hsa_circ_0001445 hsa_circ_SMARCA5 - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated "Collectively, our data show circSMARCA5 as a promising druggable tumor suppressor in GBM and suggest that it may exert its function by tethering the RBP SRSF1." 3 circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated CircHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma. 6 Hsa_circ_0001649: A circular RNA and potential novel biomarker for colorectal cancer. hsa_circ_0001649 hsa_circ_SHPRH - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "In conclusion, this study showed that the expression level of hsa_circ_0001649 was down-regulated in CRC and could use it as a new biomarker for specific and sensitive inspection of CRC." 1 A novel prognostic biomarker for cholangiocarcinoma: circRNA Cdr1as. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR up-regulated Our finding suggested that circRNA Cdr1as may serve as a potential vicious molecular biomarker to predict the aggressive tumor progression and worse prognosis for CCA patients. 2 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis. - - circRNA-000911 DOID:1612 breast cancer breast cancer microarray down-regulated "On the whole, our findings indicate that circRNA-000911 plays an anti-oncogenic role in breast cancer and may thus serve as a promising therapeutic target for patients with breast cancer. Therefore, the overexpression of circRNA-000911 may provide a future direction which may aid in the development of a novel treatment strategy for breast cancer." 1 Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion. - - circ0000082 DOID:1909 melanoma melanoma "RT-qPCR, microarray" up-regulated "The present study revealed several differentially expressed circRNAs, indicating that the newly identified circRNAs may provide new therapeutic targets for melanoma." 1 Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion. - - circ0016418 DOID:1909 melanoma melanoma "RT-qPCR, microarray" up-regulated "The present study revealed several differentially expressed circRNAs, indicating that the newly identified circRNAs may provide new therapeutic targets for melanoma." 1 Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion. - - circ0023988 DOID:1909 melanoma melanoma "RT-qPCR, microarray" down-regulated "The present study revealed several differentially expressed circRNAs, indicating that the newly identified circRNAs may provide new therapeutic targets for melanoma." 1 Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion. - - circ0008157 DOID:1909 melanoma melanoma "RT-qPCR, microarray" down-regulated "The present study revealed several differentially expressed circRNAs, indicating that the newly identified circRNAs may provide new therapeutic targets for melanoma." 1 Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion. - - circ0030388 DOID:1909 melanoma melanoma "RT-qPCR, microarray" down-regulated "The present study revealed several differentially expressed circRNAs, indicating that the newly identified circRNAs may provide new therapeutic targets for melanoma." 1 Microarray profile of circular RNAs identifies hsa_circ_0014130 as a new circular RNA biomarker in non-small cell lung cancer. hsa_circ_0014130 hsa_circ_PIP5K1A - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated "In summary, our findings indicated that hsa_circ_0014130 could be used as a potential NSCLC biomarker and might be closely related to the carcinogenesis of NSCLC." 4 Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model. - - mmu_circRNA_017963 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1." 1 Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model. - - mmu_circRNA_003540 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1." 1 Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model. - - mmu_circRNA_013699 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1." 1 Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model. - - mmu_circRNA_012180 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1." 2 Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model. - - mmu_circRNA_006173 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1." 1 Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model. - - mmu_circRNA_006229 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1." 1 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. - - hsa_circRNA_001937 DOID:399 tuberculosis active tuberculosis "RT-qPCR, microarray" up-regulated "This study identified a set of deregulated circRNAs in active TB PBMCs, our data also suggest that hsa_circRNA_001937 can be used as a potential diagnostic biomarker of TB." 2 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. - - hsa_circRNA_009024 DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" up-regulated "Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. " 1 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. - - hsa_circRNA_001937 DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" up-regulated "Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. " 2 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. - - hsa_circRNA_005086 DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" up-regulated "Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. " 1 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. - - hsa_circRNA_102101 DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" down-regulated "Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. " 1 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. - - hsa_circRNA_104964 DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" down-regulated "Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. " 1 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. - - hsa_circRNA_104296 DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" down-regulated "Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. " 1 Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression. hsa_circ_0000977 hsa_circ_NOL10 - DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression. 2 CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/beta-catenin axis. hsa_circ_0067934 - circ_0067934 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated the circ_0067934/miR-1324/FZD5/beta-catenin signaling axis might serve as a promising therapeutic target for HCC intervention. 2 Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis. hsa_circ_0087537 hsa_circ_FAM120A - DOID:8398 osteoarthritis facet joint osteoarthritis "RT-qPCR, microarray" up-regulated Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR. 1 Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis. hsa_circ_0072668 hsa_circ_ADAMTS6 - DOID:8398 osteoarthritis facet joint osteoarthritis "RT-qPCR, microarray" up-regulated Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR. 2 Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis. hsa_circ_0071896 hsa_circ_TRIO - DOID:8398 osteoarthritis facet joint osteoarthritis "RT-qPCR, microarray" up-regulated Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR. 2 Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis. hsa_circ_0063781 hsa_circ_PPARA - DOID:8398 osteoarthritis facet joint osteoarthritis "RT-qPCR, microarray" up-regulated Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR. 1 Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis. hsa_circ_0053743 hsa_circ_BIRC6 - DOID:8398 osteoarthritis facet joint osteoarthritis "RT-qPCR, microarray" up-regulated Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR. 1 Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis. hsa_circ_0029067 hsa_circ_CLIP1 - DOID:8398 osteoarthritis facet joint osteoarthritis "RT-qPCR, microarray" down-regulated Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR. 1 Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis. hsa_circ_0005127 hsa_circ_REXO2 - DOID:8398 osteoarthritis facet joint osteoarthritis "RT-qPCR, microarray" down-regulated Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR. 1 Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk. - hsa_circ_GRB10 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated "the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD." 3 Identification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis. hsa_circ_0004712 - circ_0004712 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" up-regulated "This study provides evidence that circRNAs are differentially expressed between eutopic and normal endometrium, which suggests that circRNAs are candidate factors in the activation of endometriosis. circ_0002198 and circ_0004712 may be potential novel biomarkers for the diagnosis of ovarian endometriosis." 2 Identification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis. hsa_circ_0002198 - circ_0002198 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" up-regulated "This study provides evidence that circRNAs are differentially expressed between eutopic and normal endometrium, which suggests that circRNAs are candidate factors in the activation of endometriosis. circ_0002198 and circ_0004712 may be potential novel biomarkers for the diagnosis of ovarian endometriosis." 3 The Relationship of Circular RNAs With Ovarian Endometriosis. hsa_circ_0004712 - circ_0004712 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" up-regulated "This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets." 2 The Relationship of Circular RNAs With Ovarian Endometriosis. hsa_circ_0002198 - circ_0002198 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" up-regulated "This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets." 3 The Relationship of Circular RNAs With Ovarian Endometriosis. hsa_circ_0002503 - circ_0002503 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" up-regulated "This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets." 1 The Relationship of Circular RNAs With Ovarian Endometriosis. hsa_circ_0000284 - circ_0000284 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" down-regulated "This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets." 1 The Relationship of Circular RNAs With Ovarian Endometriosis. hsa_circ_0003570 - circ_0003570 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" down-regulated "This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets." 1 The Relationship of Circular RNAs With Ovarian Endometriosis. hsa_circ_0008951 - circ_0008951 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" up-regulated "This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets." 1 The Relationship of Circular RNAs With Ovarian Endometriosis. hsa_circ_0017248 - circ_0017248 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" up-regulated "This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets." 1 The Relationship of Circular RNAs With Ovarian Endometriosis. hsa_circ_0034762 - circ_0034762 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" down-regulated "This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets." 1 ERbeta-Mediated Alteration of circATP2B1 and miR-204-3p Signaling Promotes Invasion of Clear Cell Renal Cell Carcinoma. - hsa_circ_ATP2B1 - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR down-regulated "These results identify an ERbeta/circATP2B1/miR-204-3p/FN1 signaling axis in RCC, suggesting ERbeta and circular RNA ATP2B1 as prognostic biomarkers for this disease." 1 circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150. - hsa_circ_HLA-C - DOID:0080162 lupus nephritis lupus nephritis "RT-qPCR, microarray" up-regulated CircHLA-C may play an important role in the pathogenesis of lupus nephritis by sponging miR-150. 1 circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways. - hsa_circ_SHKBP1 circ-SHKBP1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "the present study demonstrated that circ-SHKBP1 regulated the angiogenesis of GECs through miR-544a/FOXP1 and miR-379/FOXP2 pathways, and these findings might provide a potential target and effective strategy for combined therapy of gliomas." 2 Profiles of circular RNAs in human placenta and their potential roles related to preeclampsia. hsa_circ_0007121 hsa_circ_None - DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "Collectively, this study demonstrates the existence of dysregulated circRNAs in the placenta of preeclampsia patients and annotates their potential roles in the pathogenesis of the disease. Encouragingly, hsa_circ_0007121 was found to be a potential noninvasive biomarker for the prediction of preeclampsia." 2 Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506. - - circRNA-000284 DOID:4362 cervical cancer cervical cancer microarray up-regulated "Finally, the tumor promoting effect of circRNA-000284 was abolished by co-expression of miR-506 mimics or Snail-2 silencing vector. In conclusion, circRNA-000284 promotes cell proliferation and invasion in cervical cancer, and may serve as a promising therapeutic target for cervical cancer patients." 1 Identification of differentially expressed circular RNAs during TGF-ss1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells. - - chr5:90817794-90827570 DOID:1287 cardiovascular system disease cardiovascular disease "RT-qPCR, RNA-seq" up-regulated "Chr5:90817794|90827570, chr8:71336875|71337745, and chr6:22033342|22038870 were significantly up-regulated in TGF-beta1-treated rat CAEC. " 1 Identification of differentially expressed circular RNAs during TGF-ss1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells. - - chr8:71336875-71337745 DOID:1287 cardiovascular system disease cardiovascular disease "RT-qPCR, RNA-seq" up-regulated "Chr5:90817794|90827570, chr8:71336875|71337745, and chr6:22033342|22038870 were significantly up-regulated in TGF-beta1-treated rat CAEC. " 1 Identification of differentially expressed circular RNAs during TGF-ss1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells. - - chr6:22033342-22038870 DOID:1287 cardiovascular system disease cardiovascular disease "RT-qPCR, RNA-seq" up-regulated "Chr5:90817794|90827570, chr8:71336875|71337745, and chr6:22033342|22038870 were significantly up-regulated in TGF-beta1-treated rat CAEC. " 1 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. - - circRNA.1030 DOID:9351 diabetes mellitus gestational diabetes mellitus "RT-qPCR, RNA-seq" up-regulated CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM. 1 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. - - circRNA.5333 DOID:9351 diabetes mellitus gestational diabetes mellitus "RT-qPCR, RNA-seq" up-regulated CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM. 1 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. - - circRNA.33299 DOID:9351 diabetes mellitus gestational diabetes mellitus "RT-qPCR, RNA-seq" up-regulated CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM. 1 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. - - circRNA.20159 DOID:9351 diabetes mellitus gestational diabetes mellitus "RT-qPCR, RNA-seq" down-regulated CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM. 1 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. - - circRNA.37134 DOID:9351 diabetes mellitus gestational diabetes mellitus "RT-qPCR, RNA-seq" down-regulated CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM. 1 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. - - circRNA.22054 DOID:9351 diabetes mellitus gestational diabetes mellitus "RT-qPCR, RNA-seq" down-regulated CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM. 1 A potential risk factor of essential hypertension in case-control study: Circular RNA hsa_circ_0037911. hsa_circ_0037911 hsa_circ_GSPT1 - DOID:10825 essential hypertension essential hypertension RT-qPCR up-regulated Our findings suggested that higher expression hsa_circ_0037911 may be key circRNAs for EH development by changing the concentration of Scr and could be a stable biomarker for early diagnosis of EH. 2 circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1. - mmu_circ_HECTD1 - DOID:850 lung disease pulmonary silicosis RT-qPCR up-regulated Our findings reveal a potentially new function for the circHECTD1/HECTD1 pathway and suggest a possible mechanism of fibrosis in patients with pulmonary silicosis. 1 CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Taken together, our data indicate that circHIPK3 may have considerable potential as a prognostic biomarker in CRC, and support the notion that therapeutic targeting of the c-Myb/circHIPK3/miR-7 axis may be a promising treatment approach for CRC patients." 2 Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis. - hsa_circ_MAN2B2 - DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" up-regulated "Taken together, our study demonstrated that circMAN2B2 acts as an oncogenic role in lung cancer through promoting FOXK1 expression by sponging miR-1275." 1 Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer. hsa_circ_0000172 hsa_circ_CSRP1 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "In summary, by investigating the differentially expressed circRNAs for clinical tumor samples, we have revealed a complex regulatory network for bladder cancer. The signaling pathways involved in the proliferation, metastasis, and transformation of the cancer are predicted to be subject to regulations of these differential circRNAs." 1 Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer. hsa_circ_0002495 hsa_circ_RORA - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "In summary, by investigating the differentially expressed circRNAs for clinical tumor samples, we have revealed a complex regulatory network for bladder cancer. The signaling pathways involved in the proliferation, metastasis, and transformation of the cancer are predicted to be subject to regulations of these differential circRNAs." 1 Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer. - - Chr22: 28943661 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "In summary, by investigating the differentially expressed circRNAs for clinical tumor samples, we have revealed a complex regulatory network for bladder cancer. The signaling pathways involved in the proliferation, metastasis, and transformation of the cancer are predicted to be subject to regulations of these differential circRNAs." 1 Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer. - - Chr5: 158368701 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "In summary, by investigating the differentially expressed circRNAs for clinical tumor samples, we have revealed a complex regulatory network for bladder cancer. The signaling pathways involved in the proliferation, metastasis, and transformation of the cancer are predicted to be subject to regulations of these differential circRNAs." 1 Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer. - - Chr9: 74522734 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" down-regulated "In summary, by investigating the differentially expressed circRNAs for clinical tumor samples, we have revealed a complex regulatory network for bladder cancer. The signaling pathways involved in the proliferation, metastasis, and transformation of the cancer are predicted to be subject to regulations of these differential circRNAs." 1 "Overexpressed circPVT1, a potential new circular RNA biomarker, contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1." - hsa_circ_PVT1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated These findings may provide a new insight into the role of circPVT1 as a biomarker for the diagnosis and treatment target of OS. 5 Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression. hsa_circ_0014717 hsa_circ_CCT3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Taken together, hsa_circ_0014717 acts as a potential tumor suppressor that inhibits CRC growth, partly at least, through upregulating p16 expression. Furthermore, our present study may provide a promising therapeutic target for CRC patients." 2 Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics. hsa_circ_0084927 hsa_circ_ESRP1 - DOID:6543 acne acne "RT-qPCR, RNA-seq" down-regulated "Five candidate circRNAs (circRNA_0084927, circRNA_0001073, circRNA_0005941, circRNA_0086376 and circRNA_0018168) were validated to have significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis." 1 Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics. hsa_circ_0001073 hsa_circ_ACVR2A - DOID:6543 acne acne "RT-qPCR, RNA-seq" down-regulated "Five candidate circRNAs (circRNA_0084927, circRNA_0001073, circRNA_0005941, circRNA_0086376 and circRNA_0018169) were validated to have significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis." 1 Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics. hsa_circ_0005941 hsa_circ_FTO - DOID:6543 acne acne "RT-qPCR, RNA-seq" down-regulated "Five candidate circRNAs (circRNA_0084927, circRNA_0001073, circRNA_0005941, circRNA_0086376 and circRNA_0018170) were validated to have significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis." 1 Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics. hsa_circ_0086376 hsa_circ_NFIB - DOID:6543 acne acne "RT-qPCR, RNA-seq" down-regulated "Five candidate circRNAs (circRNA_0084927, circRNA_0001073, circRNA_0005941, circRNA_0086376 and circRNA_0018171) were validated to have significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis." 1 Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics. hsa_circ_0018168 hsa_circ_PARD3 - DOID:6543 acne acne "RT-qPCR, RNA-seq" down-regulated "Five candidate circRNAs (circRNA_0084927, circRNA_0001073, circRNA_0005941, circRNA_0086376 and circRNA_0018172) were validated to have significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis." 1 Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis. hsa_circ_0001859 hsa_circ_TCONS_l2_00028722 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RNA-seq up-regulated Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis. 1 Identification of aberrant circular RNA expression and its potential clinical value in primary great saphenous vein varicosities. hsa_circ_0089810 hsa_circ_None - DOID:799 varicose veins primary great saphenous vein varicosities "RT-qPCR, RNA-seq" down-regulated "This study demonstrated that circRNAs were differentially expressed in PGSVVs, and highlights the crucial roles of circRNAs in the pathogenesis of PGSVVs and indicates that hsa_circ_0006427, hsa_circ_0089810 and hsa_circ_0005267 might be potential diagnostic and clinical biological markers." 1 Identification of aberrant circular RNA expression and its potential clinical value in primary great saphenous vein varicosities. hsa_circ_0006427 hsa_circ_BCAR3 - DOID:799 varicose veins primary great saphenous vein varicosities "RT-qPCR, RNA-seq" down-regulated "This study demonstrated that circRNAs were differentially expressed in PGSVVs, and highlights the crucial roles of circRNAs in the pathogenesis of PGSVVs and indicates that hsa_circ_0006427, hsa_circ_0089810 and hsa_circ_0005267 might be potential diagnostic and clinical biological markers." 1 Identification of aberrant circular RNA expression and its potential clinical value in primary great saphenous vein varicosities. hsa_circ_0005267 hsa_circ_C14orf118 - DOID:799 varicose veins primary great saphenous vein varicosities "RT-qPCR, RNA-seq" down-regulated "This study demonstrated that circRNAs were differentially expressed in PGSVVs, and highlights the crucial roles of circRNAs in the pathogenesis of PGSVVs and indicates that hsa_circ_0006427, hsa_circ_0089810 and hsa_circ_0005267 might be potential diagnostic and clinical biological markers." 1 The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma. - hsa_circ_PRKCI - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated CircPRKCI functioned as a sponge for both miR-545 and miR-589 and abrogated their suppression of the protumorigenic transcription factor E2F7 Intratumor injection of cholesterol-conjugated siRNA specifically targeting circPRKCI inhibited tumor growth in a patient-derived lung adenocarcinoma xenograft model. 3 Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3. hsa_circ_0011946 hsa_circ_SCMH1 - DOID:1612 breast cancer breast cancer RNA-seq up-regulated "Together, these results indicate that hsa_circ_0011946 and RFC3 comprise a novel pathway involved in the progression of breast cancer." 1 Increased expression of circRNA_102231 in lung cancer and its clinical significance. - - circRNA_102231 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated our study demonstrated that circRNA_102231 could act as a potential biomarker and therapeutic target for lung cancer patients. 1 Hsa_circ_0007534/miR-761/ZIC5 regulatory loop modulates the proliferation and migration of glioma cells. hsa_circ_0007534 hsa_circ_DDX42 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated Our results suggested that hsa_circ_0007534/miR-761/ZIC5 regulatory loop might be a promising therapeutic target for glioma treatment. 2 Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients. hsa_circ_0049224 hsa_circ_DNMT1 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR down-regulated "Hsa_circ_0049224 and has_circ_0049220 are probable factors involved in the pathogenesis of SLE, and they have potential clinical value in SLE." 2 Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients. hsa_circ_0049220 hsa_circ_DNMT1 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR down-regulated "Hsa_circ_0049224 and has_circ_0049220 are probable factors involved in the pathogenesis of SLE, and they have potential clinical value in SLE." 2 Circular RNA circC3P1 suppresses hepatocellular carcinoma growth and metastasis through miR-4641/PCK1 pathway. - hsa_circ_C3P1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated our findings illustrated that circC3P1 acts as a tumor suppressor via enhancing PCK1 expression by sponging miR-4641 in HCC. 1 The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma. - - hsa_circ_100571 DOID:686 liver carcinoma primary hepatic carcinoma "RT-qPCR, microarray" down-regulated Five types of circular ribonucleic acid-related micro-ribonucleic acids had varying degrees of upregulation and downregulation between perioperative transplantation of primary hepatic carcinoma patients and normal controls; the hsa_circ_102347 is most likely to have association with primary hepatic carcinoma. 1 The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma. - - hsa_circ_400031 DOID:686 liver carcinoma primary hepatic carcinoma "RT-qPCR, microarray" down-regulated Five types of circular ribonucleic acid-related micro-ribonucleic acids had varying degrees of upregulation and downregulation between perioperative transplantation of primary hepatic carcinoma patients and normal controls; the hsa_circ_102348 is most likely to have association with primary hepatic carcinoma. 1 The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma. - - hsa_circ_102032 DOID:686 liver carcinoma primary hepatic carcinoma "RT-qPCR, microarray" up-regulated Five types of circular ribonucleic acid-related micro-ribonucleic acids had varying degrees of upregulation and downregulation between perioperative transplantation of primary hepatic carcinoma patients and normal controls; the hsa_circ_102349 is most likely to have association with primary hepatic carcinoma. 1 The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma. - - hsa_circ_103096 DOID:686 liver carcinoma primary hepatic carcinoma "RT-qPCR, microarray" up-regulated Five types of circular ribonucleic acid-related micro-ribonucleic acids had varying degrees of upregulation and downregulation between perioperative transplantation of primary hepatic carcinoma patients and normal controls; the hsa_circ_102350 is most likely to have association with primary hepatic carcinoma. 1 The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma. - - hsa_circ_102347 DOID:686 liver carcinoma primary hepatic carcinoma "RT-qPCR, microarray" up-regulated Five types of circular ribonucleic acid-related micro-ribonucleic acids had varying degrees of upregulation and downregulation between perioperative transplantation of primary hepatic carcinoma patients and normal controls; the hsa_circ_102351 is most likely to have association with primary hepatic carcinoma. 1 Identification of the tumor_suppressive function of circular RNA FOXO3 in non_small cell lung cancer through sponging miR_155. - hsa_circ_FOXO3 circRNA_FOXO3 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "These results suggest that circRNA_FOXO3 is a tumor_suppressor in NSCLC and may serve as a promising therapeutic target. Therefore, restoration of circRNA_FOXO3 expression could be a future approach to develop a novel treatment strategy." 2 Microarray expression profile analysis of circular RNAs in pancreatic cancer. - - hsa_circRNA_000167 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" down-regulated The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer. 1 Microarray expression profile analysis of circular RNAs in pancreatic cancer. - - hsa_circRNA_100433 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer. 1 Microarray expression profile analysis of circular RNAs in pancreatic cancer. - - hsa_circRNA_101717 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer. 1 Microarray expression profile analysis of circular RNAs in pancreatic cancer. - - hsa_circRNA_102049 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer. 1 Microarray expression profile analysis of circular RNAs in pancreatic cancer. - - hsa_circRNA_102051 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer. 1 Microarray expression profile analysis of circular RNAs in pancreatic cancer. - - hsa_circRNA_102619 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer. 1 Microarray expression profile analysis of circular RNAs in pancreatic cancer. - - hsa_circRNA_103076 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer. 1 Microarray expression profile analysis of circular RNAs in pancreatic cancer. - - hsa_circRNA_103390 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer. 1 Microarray expression profile analysis of circular RNAs in pancreatic cancer. - - hsa_circRNA_104084 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer. 1 Microarray expression profile analysis of circular RNAs in pancreatic cancer. - - hsa_circRNA_104270 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer. 1 Circular RNA hsa_circ_0000673 promotes hepatocellular carcinoma malignance by decreasing miR-767-3p targeting SET. hsa_circ_0000673 hsa_circ_RSL1D1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated our findings demonstrated that hsa_circ_0000673 promoted HCC malignant behaviors via regulating miR-767-3p/SET pathway. 1 Down-regulation of hsa_circ_0001649 in hepatocellular carcinoma predicts a poor prognosis. hsa_circ_0001649 hsa_circ_SHPRH - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq down-regulated "Hsa_circ_0001649 could act as a novel prognostic biomarker for HCC patients. In addition, hsa_circ_ 0001649 might be a potential therapeutic target for HCC." 4 Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated our study provided novel evidence that ciRS-7 accelerates ESCC progression by acting as a miR-876-5p sponge to enhance MAGE-A family expression. 4 Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma. - - hsa_circRNA_103827 DOID:3907 lung squamous cell carcinoma lung squamous cell carcinoma "RT-qPCR, microarray" up-regulated "Among these, hsa_circRNA_103827 and hsa_circRNA_000122 might be served as potential prognostic biomarkers and therapeutic target for LSCC." 1 Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma. - - hsa_circRNA_000122 DOID:3907 lung squamous cell carcinoma lung squamous cell carcinoma "RT-qPCR, microarray" down-regulated "Among these, hsa_circRNA_103827 and hsa_circRNA_000122 might be served as potential prognostic biomarkers and therapeutic target for LSCC." 1 Competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia. hsa_circ_0036877 hsa_circ_FURIN - DOID:10591 pre-eclampsia preeclampsia "RT-qPCR, microarray" up-regulated "Our study is the first systematic profiling of ceRNAs in placentas of PE patients and revealed the global ceRNA network integration in PE. Moreover, hsa_circ_0036877 can function as a ceRNA and serve as a potential novel blood biomarker for early PE." 2 Circular RNA circ-4099 is induced by TNF-alpha and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration. - - circ-4099 DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" up-regulated Circular RNA circ-4099 is induced by TNF-alpha and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration. 1 "Circular RNA circCDK13 suppresses cell proliferation, migration and invasion by modulating the JAK/STAT and PI3K/AKT pathways in liver cancer." - hsa_circ_CDK13 - DOID:3571 liver cancer liver cancer RT-qPCR down-regulated "On the whole, the findings of this study indicate that circCDK13 is a novel circular RNA that suppresses liver cancer progression, and that these suppressive effects are possibly mediated via the JAK/STAT and PI3K/AKT signaling pathways." 1 Screening potential biomarkers for colorectal cancer based on circular RNA chips. hsa_circ_0126897 hsa_circ_CBC1 - DOID:9256 colorectal cancer colorectal cancer microarray up-regulated "hsa_circ_0126897_CBC1 may be a potential biomarker for CRC, and the cell cycle was closely associated with the occurrence and development of CRC." 1 "Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and promoting cell proliferation." - - circRNA_100284 DOID:684 hepatocellular carcinoma malignant transformation of human hepatic cells RT-qPCR up-regulated The findings support the concept that exosomal circRNAs are involved in cell-cell communication during carcinogenesis induced by arsenite. 1 Circular RNA circNASP modulates the malignant behaviors in osteosarcoma via miR-1253/FOXF1 pathway. - hsa_circ_NASP - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Taken together, our findings demonstrated that circNASP contributes to malignant behaviors of OS cells by miR-1253/FOXF1 pathway, which suggested circNASP/miR-1253/FOXF1axis might be a potential therapeutic target." 1 "Circular RNA hsa-circ-0012129 Promotes Cell Proliferation and Invasion in 30 Cases of Human Glioma and Human Glioma Cell Lines U373, A172, and SHG44, by Targeting MicroRNA-661 (miR-661)." hsa_circ_0012129 hsa_circ_B4GALT2 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "The findings of this study indicated that, in human glioma cells, the circRNA, hsa-circ-0012129 might act as a natural miR-661 sponge, and that miR-661 could have suppressive effects on the expression of circ-0012129." 2 "Circular RNA hsa_circ_0008344 regulates glioblastoma cell proliferation, migration, invasion, and apoptosis." hsa_circ_0008344 hsa_circ_UBAP2 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, microarray" up-regulated Hsa_circ_0008344 is upregulated in glioblastoma and may contribute to the progression of this malignancy. 1 Hsa_circ_0079530 promotes cell proliferation and invasion in non-small cell lung cancer. hsa_circ_0079530 hsa_circ_TWIST1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated These results indicated that hsa_circ_0075930 upregulation may be a critical oncogene and potential new biomarker in NSCLC. 3 Circular RNA PVT1 expression and its roles in acute lymphoblastic leukemia. - hsa_circ_PVT1 - DOID:9952 acute lymphoblastic leukemia acute lymphoblastic leukemia RT-qPCR up-regulated CircPVT1 is upregulated in ALL. Silencing circPVT1 results in cell growth arrest and apoptosis of the cells. Our results also suggested a therapeutic potential of targeting circPVT1 in ALL. 2 CircRNA-Cdr1as Exerts Anti-Oncogenic Functions in Bladder Cancer by Sponging MicroRNA-135a. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated Cdr1as is down-regulated and sponges multiple miRNAs in bladder cancer. It exerts anti-oncogenic functions by sponging microRNA-135a. 2 Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302. - - hsa_circRNA_103809 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "In conclusion, our findings illustrated a novel hsa_circRNA_103809/miR-4302/ZNF121/MYC regulatory signaling pathway in lung cancer progression." 1 circFADS2 regulates lung cancer cells proliferation and invasion via acting as a sponge of miR-498. - hsa_circ_FADS2 hsa_circRNA_100833 DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" up-regulated "Taken together, our findings indicated that circFADS2 was an effective tumor promoter in lung cancer progression, and its functions were performed by regulating the expression of miR-498. These data suggested that circFADS2 could act as a target for lung cancer treatment." 1 Differential Expression Profiles of Circular RNAs During Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells. - - mmu_circRNA_013422 DOID:12347 osteogenesis imperfecta osteogenesis microarray up-regulated the circRNA-miRNA-mRNA pathways may provide information on novel mechanisms and targets for clinical investigations on bone formation and regeneration. 1 Differential Expression Profiles of Circular RNAs During Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells. - - mmu_circRNA_22566 DOID:12347 osteogenesis imperfecta osteogenesis microarray up-regulated the circRNA-miRNA-mRNA pathways may provide information on novel mechanisms and targets for clinical investigations on bone formation and regeneration. 1 Circular RNA expression profile and potential function of hsa_circ_0045272 in systemic lupus erythematosus. hsa_circ_0045272 hsa_circ_ERN1 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" down-regulated Our study demonstrated dysregulated circRNAs in SLE and revealed the function of hsa_circ_0045272 in negatively regulating apoptosis and interleukin-2 secretion and its potential mechanism. 1 Circular RNA circMYO9B facilitates breast cancer cell proliferation and invasiveness via upregulating FOXP4 expression by sponging miR-4316. - hsa_circ_MYO9B - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "In conclusion, our findings demonstrated a key role of circMYO9B/miR-4316/FOXP4 axis in regulating BC progression." 1 CircRNF13 regulates the invasion and metastasis in lung adenocarcinoma by targeting miR-93-5p. - hsa_circ_RNF13 - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated Our data suggest that circRNF13 represents a potential novel biomarker and a therapeutic target of lung adenocarcinoma. 1 Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer disease-like rats using microarray analysis. - - rno_circRNA_001555 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated Our results suggest the involvement of different ncRNA expression patterns in the pathogenesis of AD. Our findings provide a novel perspective for further research into AD pathogenesis and might facilitate the development of novel therapeutics targeting ncRNAs. 1 Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer disease-like rats using microarray analysis. - - rno_circRNA_010684 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated Our results suggest the involvement of different ncRNA expression patterns in the pathogenesis of AD. Our findings provide a novel perspective for further research into AD pathogenesis and might facilitate the development of novel therapeutics targeting ncRNAs. 1 Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer disease-like rats using microarray analysis. - - rno_circRNA_013981 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated Our results suggest the involvement of different ncRNA expression patterns in the pathogenesis of AD. Our findings provide a novel perspective for further research into AD pathogenesis and might facilitate the development of novel therapeutics targeting ncRNAs. 1 Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer disease-like rats using microarray analysis. - - rno_circRNA_017759 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated Our results suggest the involvement of different ncRNA expression patterns in the pathogenesis of AD. Our findings provide a novel perspective for further research into AD pathogenesis and might facilitate the development of novel therapeutics targeting ncRNAs. 1 Mm9_circ_009056 enhances osteogenesis by targeting BMP7 via CGRP-mediated miR-22-3p. - - mm9_circ_009056 DOID:12347 osteogenesis imperfecta enhances osteogenesis "RT-qPCR, microarray" up-regulated mm9_circ_009056 may function as a sponge for miR-22-3p to regulate osteogenesis in CGRP-induced cells. 1 Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer. - hsa_circ_PDE8A circ-PDE8A DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma microarray up-regulated "Circ-PDE8A may play an important role in tumor invasion, and exosomal circ-PDE8A may be a useful marker of PDAC diagnosis or progression." 1 Emerging roles of hsa_circ_0005075 targeting miR-431 in the progress of HCC. hsa_circ_0005075 hsa_circ_EIF4G3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated These results suggest hsa_circ_0005075 promotes HCC via miR-431 regulation. 4 Hsa_circ_0071589 promotes carcinogenesis via the miR-600/EZH2 axis in colorectal cancer. hsa_circ_0071589 hsa_circ_FAT1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated These results demonstrated that the hsa_circ_0071589/miR-600/EZH2 axis may play critical regulatory roles in the pathogenesis of CRC and may serve as a novel therapy target in CRC. 2 RNA-Seq profiling of circular RNAs in human laryngeal squamous cell carcinomas. - - "hsa_circ:chr20:31876585-31,897,648" DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR down-regulated "Validation of down-regulation of hsa_circ:chr20:31876585-31,897,648 in LSCC compared to each adjunctive tissue by Q-RT-PCR, indicating that hsa_circ:chr20:31876585-31,897,648 may be a novel promising tumor suppresser in LSCC." 1 A novel plasma circular RNA circFARSA is a potential biomarker for non-small cell lung cancer. - hsa_circ_FARSA - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" up-regulated "Summarily, this study revealed circRNA profile of NSCLC for the first time and provided the evidence of plasma circFARSA as a potential noninvasive biomarker for this malignancy." 2 "RNA-binding protein trinucleotide repeat-containing 6A regulates the formation of circular RNA circ0006916, with important functions in lung cancer cells." - - circ0006916 DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" down-regulated "These results demonstrate that TNRC6A regulates the biogenesis of the circRNA circ0006916, which has a regulatory role in cell growth." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_406841 DOID:1781 thyroid gland cancer thyroid cancer microarray up-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_000905 DOID:1781 thyroid gland cancer thyroid cancer microarray up-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_019252 DOID:1781 thyroid gland cancer thyroid cancer microarray up-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_089761 DOID:1781 thyroid gland cancer thyroid cancer microarray up-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_006050 DOID:1781 thyroid gland cancer thyroid cancer microarray up-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_074298 DOID:1781 thyroid gland cancer thyroid cancer microarray up-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_066556 DOID:1781 thyroid gland cancer thyroid cancer microarray up-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_101321 DOID:1781 thyroid gland cancer thyroid cancer microarray up-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_023016 DOID:1781 thyroid gland cancer thyroid cancer microarray up-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_019744 DOID:1781 thyroid gland cancer thyroid cancer microarray up-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_404686 DOID:1781 thyroid gland cancer thyroid cancer microarray down-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_000367 DOID:1781 thyroid gland cancer thyroid cancer microarray down-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_001729 DOID:1781 thyroid gland cancer thyroid cancer microarray down-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_004183 DOID:1781 thyroid gland cancer thyroid cancer microarray down-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_100790 DOID:1781 thyroid gland cancer thyroid cancer microarray down-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_104270 DOID:1781 thyroid gland cancer thyroid cancer microarray down-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_102049 DOID:1781 thyroid gland cancer thyroid cancer microarray down-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_406494 DOID:1781 thyroid gland cancer thyroid cancer microarray down-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_100787 DOID:1781 thyroid gland cancer thyroid cancer microarray down-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. - - hsa_circRNA_082319 DOID:1781 thyroid gland cancer thyroid cancer microarray down-regulated "In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray." 1 Circular RNA hsa_circ_0023404 exerts an oncogenic role in cervical cancer through regulating miR-136/TFCP2/YAP pathway. hsa_circ_0023404 hsa_circ_RNF121 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Taken together, our study for the first time demonstrated the pivot role of hsa_circ_0023404 and revealed a novel regulatory loop of hsa_circ_0023404/miR-136/TFCP2/YAP axis in CC progression." 3 Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration. - hsa_circ_ZRANB1 - DOID:8466 retinal degeneration retinal neurodegeneration RT-qPCR up-regulated cZRANB1 acts as miRNA sponge to regulate M¨ąller cell function through cZRANB1/miR-217/RUNX2 network. Intervention of cZRANB1 expression would become an effective strategy for treating retinal neurodegeneration. 1 "CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential Novel Biomarkers for the Prediction of Preeclampsia." hsa_circ_0004904 hsa_circ_POLE2 - DOID:10591 pre-eclampsia preeclampsia "RT-qPCR, microarray" up-regulated "This is the first study to report circRNA profiling in patients with PE prior to the onset of symptoms. Our data suggested that hsa_circ_0004904 and hsa_circ_0001855 combined with PAPP-A might be promising biomarkers for the detection of PE. Moreover, circRNAs may provide new insights into the potential mechanisms underlying the pathophysiology of PE." 1 "CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential Novel Biomarkers for the Prediction of Preeclampsia." hsa_circ_0001855 hsa_circ_RNF38 - DOID:10591 pre-eclampsia preeclampsia "RT-qPCR, microarray" up-regulated "This is the first study to report circRNA profiling in patients with PE prior to the onset of symptoms. Our data suggested that hsa_circ_0004904 and hsa_circ_0001855 combined with PAPP-A might be promising biomarkers for the detection of PE. Moreover, circRNAs may provide new insights into the potential mechanisms underlying the pathophysiology of PE." 1 CircRNA_0023642 promotes migration and invasion of gastric cancer cells by regulating EMT. hsa_circ_0023642 hsa_circ_UVRAG circRNA_0023642 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Our findings suggest that circRNA_0023642 serves as a metastasis activator by promoting EMT and may represent a novel molecular therapeutic target for GC. 2 circRNA_0084043 promote malignant melanoma progression via miR-153-3p/Snail axis. hsa_circ_0084043 hsa_circ_ADAM9 circRNA_0084043 DOID:1909 melanoma melanoma microarray up-regulated "Overall, this result elucidates a new mechanism for circRNA_0084043 in melanoma development and provides a potential therapeutic target for melanoma patients." 3 "Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells." hsa_circ_0066444 - circ_0066444 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our study indicated upregulation of circ_0066444 promotes gastric cell proliferation, invasion, and migration ability and might serve as a novel biomarker for GC." 1 The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker. hsa_circ_0001445 hsa_circ_SMARCA5 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker. 3 Circular RNA 0068669 as a new biomarker for hepatocellular carcinoma metastasis. hsa_circ_0068669 hsa_circ_SENP5 hsa_circ_103561 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated Our findings indicate that hsa_circ_0068669 might be served as a novel potential biomarker for HCC metastasis. 1 Decreased expression of hsa_circ_0137287 predicts aggressive clinicopathologic characteristics in papillary thyroid carcinoma. hsa_circ_0137287 hsa_circ_SLC26A7 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR down-regulated Our findings suggest that hsa_circ_0137287 may serve as a novel biomarker for PTC. 1 Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq. - - hsa_circRNA001885 DOID:255 hemangioma infantile hemangioma RT-qPCR up-regulated our findings highlight the potential importance of circRNAs in the biology of IH and its response to treatment. 1 Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq. - - hsa_circRNA006612 DOID:255 hemangioma infantile hemangioma RT-qPCR up-regulated our findings highlight the potential importance of circRNAs in the biology of IH and its response to treatment. 1 Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1. - hsa_circ_CCNB1 circ-Ccnb1 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated These results shed light on the possible development of new approaches to inhibit the_alignancy of p53 mutations. 1 Circular RNA Myosin Light Chain Kinase (MYLK) Promotes Prostate Cancer Progression through Modulating Mir-29a Expression. hsa_circ_0141940 hsa_circ_MYLK circRNA-MYLK DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated We confirmed circRNA-MYLK was an oncogene in PCa and revealed a novel mechanism underlying circRNA-MYLK in PC progression. 1 CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis. - hsa_circ_IRAK3 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "Intriguingly, FOXC1 could, in turn, bind to the IRAK3 promoter, triggering a positive-feedback loop that perpetuated the circIRAK3/miR-3607/FOXC1 signaling axis. Collectively, our findings indicated that circIRAK3 may exert regulatory roles in BC metastasis and may be a potential target for metastatic BC therapy." 2 "Circular RNA circ_HIPK3 is down-regulated and suppresses cell proliferation, migration and invasion in osteosarcoma." hsa_circ_0000284 hsa_circ_HIPK3 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated our data suggest that circ_HIPK3 may become a novel potential biomarker for diagnosis and treatment target of OS. 4 Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis. hsa_circ_0008039 hsa_circ_PRKAR1B - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated our study indicated that hsa_circ_0008039 exerted oncogenic roles in breast cancer and suggested the hsa_circ_0008039/miR-432-5p/E2F3 axis might be a potential therapeutic target. 2 Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression. - hsa_circ_ZFR - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression. 1 Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma. - hsa_circ_Cul2 circ-10720 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated A circRNA-based mechanism drives Twist1-mediated regulation of vimentin during EMT and provides potential therapeutic targets for treatment of HCC. 1 Profiling and functional analysis of circular RNAs in acute promyelocytic leukemia and their dynamic regulation during all-trans retinoic acid treatment. - hsa_circ_HIPK2 circ-HIPK2 DOID:0060318 acute promyelocytic leukemia acute promyelocytic leukemia "RT-qPCR, RNA-seq" down-regulated "Our study indicates the biological functions of circRNAs in the development and treatment of APL, and provides a comprehensive circRNA resource for future studies." 1 circSMAD2 inhibits the epithelial-mesenchymal transition by targeting miR-629 in hepatocellular carcinoma. - hsa_circ_SMAD2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Altogether, our data support that circSMAD2 inhibits the migration, invasion, and EMT of HCC cells by targeting miR-629." 1 Screening differential circular RNA expression profiles reveal that hsa_circ_0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma. hsa_circ_0128298 hsa_circ_SPINK1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated hsa_circ_0128298 may promote proliferation and metastasis and potentially represents a novel diagnostic and prognostic biomarker for HCC patients. 1 Overexpressing circular RNA hsa_circ_0002052 impairs osteosarcoma progression via inhibiting Wnt/beta-catenin pathway by regulating miR-1205/APC2 axis. hsa_circ_0002052 hsa_circ_PAPPA - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated Our study suggested hsa_circ_0002052/miR-1205/APC2/Wnt/beta-catenin axis might be a potential target for OS therapy. 5 Identification and functional characterization of circRNA-0008717 as an oncogene in osteosarcoma through sponging miR-203. hsa_circ_0008717 hsa_circ_ABCB10 circRNA-0008717 DOID:3347 osteosarcoma osteosarcoma microarray up-regulated "CircRNA-0008717 plays an oncogenic role in osteosarcoma and may serve as a promising prognostic biomarker for osteosarcoma patients. Therefore, silence of circRNA-0008717 could be a future direction to develop a novel treatment strategy." 1 The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells. - hsa_circ_CCDC66 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated HGF/c-Met regulates expression of SAE2 and cirRNA CCDC66 to increase EMT and drug resistance of LADC cells. Multimodality drugs concurrently aiming at these targets would probably provide more benefits for cancer patients. 1 "CircRNA circ_0067934 silencing inhibits the proliferation, migration and invasion of NSCLC cells and correlates with unfavorable prognosis in NSCLC." hsa_circ_0067934 hsa_circ_PRKCI circ_0067934 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our data suggested that circ_0067934 functioned as an oncogenic circular RNA in NSCLC, which provided a potential prognostic biomarker and therapeutic target for NSCLC." 3 Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway. hsa_circ_0001649 hsa_circ_SHPRH - DOID:768 retinoblastoma retinoblastoma RT-qPCR down-regulated Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway. 1 CircIBTK inhibits DNA demethylation and activation of AKT signaling pathway via miR-29b in peripheral blood mononuclear cells in systemic lupus erythematosus. - hsa_circ_IBTK - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, RNA-seq" down-regulated CircIBTK was downregulated in SLE and might regulate DNA demethylation and the AKT signaling pathway via binding to miR-29b in SLE. CircIBTK and miR-29 could also act as biomarkers and therapeutic targets for SLE. 1 Identification of the tumor-suppressive function of circular RNA ITCH in glioma cells through sponging miR-214 and promoting linear ITCH expression. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:0060108 brain glioma glioma RT-qPCR down-regulated the gain and loss functional assays indicate that cir-ITCH plays an anti-oncogenic role through sponging miR-214 and regulating ITCH-Wnt/beta-catenin pathway. 1 Differential expression profile of hepatic circular RNAs in chronic hepatitis B. hsa_circ_0000650 hsa_circ_TGFB2 - DOID:2043 hepatitis B chronic hepatitis b RT-qPCR down-regulated "regression analysis of gene expression revealed a strong positive correlation between hsa_circ_0000650 and TGFbeta2 and a negative correlation between hsa_circ_0000650 and miR-6873-3p, which hinted that hsa_circ_0000650 interacted with TGFbeta2 mediated by miR-6873-3p." 1 Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245. hsa_circ_0046264 hsa_circ_P4HB - DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" down-regulated Hsa_circ_0046264 was a tumor suppressor in lung cancer. Overexpression of hsa_circ_0046264 could up-regulate BRCA2 expression through down-regulating of miR-1245. 1 Down-regulation of circ-PRKCI inhibits cell migration and proliferation in Hirschsprung disease by suppressing the expression of miR-1324 target PLCB1. - hsa_circ_PRKCI circ-PRKCI DOID:10487 Hirschsprung disease hirschsprung disease RT-qPCR down-regulated "we confirmed that circ-PRKCI functioned as a molecular sponge for miR-1324 to upregulate the expression of PLCB1. In conclusion, our present study revealed the important role of circ-PRKCI-miR-1324-PLCB1 regulatory network in HSCR, providing a novel insight for the pathogenesis of HSCR." 1 Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/beta-catenin pathway. - hsa_circ_CBFB circ-CBFB DOID:1040 chronic lymphocytic leukemia chronic lymphocytic leukemia RT-qPCR up-regulated our findings revealed that the circ-CBFB/miR-607/FZD3/Wnt/beta-catenin regulatory signaling cascade contributes to CLL progression. 1 Circular RNA In Invasive and Recurrent Clinical Nonfunctioning Pituitary Adenomas: Expression Profiles and Bioinformatic Analysis. hsa_circ_0054722 hsa_circ_USP34 - DOID:3829 pituitary adenoma pituitary adenoma microarray up-regulated "hsa_circ_0054722, hsa_circ_0007362, and hsa_circ_0012346 expression in NFA with invasion were upregulated compared with the noninvasive." 1 Circular RNA In Invasive and Recurrent Clinical Nonfunctioning Pituitary Adenomas: Expression Profiles and Bioinformatic Analysis. hsa_circ_0007362 hsa_circ_RCL1 - DOID:3829 pituitary adenoma pituitary adenoma microarray up-regulated "hsa_circ_0054722, hsa_circ_0007362, and hsa_circ_0012346 expression in NFA with invasion were upregulated compared with the noninvasive." 1 Circular RNA In Invasive and Recurrent Clinical Nonfunctioning Pituitary Adenomas: Expression Profiles and Bioinformatic Analysis. hsa_circ_0012346 hsa_circ_MKNK1 - DOID:3829 pituitary adenoma pituitary adenoma microarray up-regulated "hsa_circ_0054722, hsa_circ_0007362, and hsa_circ_0012346 expression in NFA with invasion were upregulated compared with the noninvasive." 1 Circular RNA In Invasive and Recurrent Clinical Nonfunctioning Pituitary Adenomas: Expression Profiles and Bioinformatic Analysis. hsa_circ_0062222 hsa_circ_CLTCL1 - DOID:3829 pituitary adenoma pituitary adenoma microarray down-regulated "hsa_circ_0062222, hsa_circ_0016403, hsa_circ_0033349, and hsa_circ_0049730 were downregulated." 1 Circular RNA In Invasive and Recurrent Clinical Nonfunctioning Pituitary Adenomas: Expression Profiles and Bioinformatic Analysis. hsa_circ_0016403 hsa_circ_TATDN3 - DOID:3829 pituitary adenoma pituitary adenoma microarray down-regulated "hsa_circ_0062222, hsa_circ_0016403, hsa_circ_0033349, and hsa_circ_0049730 were downregulated." 1 Circular RNA In Invasive and Recurrent Clinical Nonfunctioning Pituitary Adenomas: Expression Profiles and Bioinformatic Analysis. hsa_circ_0033349 hsa_circ_DYNC1H1 - DOID:3829 pituitary adenoma pituitary adenoma microarray down-regulated "hsa_circ_0062222, hsa_circ_0016403, hsa_circ_0033349, and hsa_circ_0049730 were downregulated." 1 Circular RNA In Invasive and Recurrent Clinical Nonfunctioning Pituitary Adenomas: Expression Profiles and Bioinformatic Analysis. hsa_circ_0049730 hsa_circ_LPHN1 - DOID:3829 pituitary adenoma pituitary adenoma microarray down-regulated "hsa_circ_0062222, hsa_circ_0016403, hsa_circ_0033349, and hsa_circ_0049730 were downregulated." 1 Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect. - - hsa_circRNA_002086 DOID:1657 ventricular septal defect ventricular septal defect RT-qPCR up-regulated "There is a significant difference in expression of the circRNA in cardiac tissue from VSD group compared to the normal group. Combined with the microarray results and previous researches, circRNAs may contribute to the occurrence of VSD by acting as miRNA sponges or by binding proteins, these possible roles for circRNAs in VSD require elucidation in additional studies." 1 Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect. - - hsa_circRNA_007878 DOID:1657 ventricular septal defect ventricular septal defect RT-qPCR down-regulated "There is a significant difference in expression of the circRNA in cardiac tissue from VSD group compared to the normal group. Combined with the microarray results and previous researches, circRNAs may contribute to the occurrence of VSD by acting as miRNA sponges or by binding proteins, these possible roles for circRNAs in VSD require elucidation in additional studies." 1 Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect. - - hsa_circRNA_100709 DOID:1657 ventricular septal defect ventricular septal defect RT-qPCR down-regulated "There is a significant difference in expression of the circRNA in cardiac tissue from VSD group compared to the normal group. Combined with the microarray results and previous researches, circRNAs may contribute to the occurrence of VSD by acting as miRNA sponges or by binding proteins, these possible roles for circRNAs in VSD require elucidation in additional studies." 1 Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect. - - hsa_circRNA_101965 DOID:1657 ventricular septal defect ventricular septal defect RT-qPCR down-regulated "There is a significant difference in expression of the circRNA in cardiac tissue from VSD group compared to the normal group. Combined with the microarray results and previous researches, circRNAs may contribute to the occurrence of VSD by acting as miRNA sponges or by binding proteins, these possible roles for circRNAs in VSD require elucidation in additional studies." 1 Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect. - - hsa_circRNA_402565 DOID:1657 ventricular septal defect ventricular septal defect RT-qPCR down-regulated "There is a significant difference in expression of the circRNA in cardiac tissue from VSD group compared to the normal group. Combined with the microarray results and previous researches, circRNAs may contribute to the occurrence of VSD by acting as miRNA sponges or by binding proteins, these possible roles for circRNAs in VSD require elucidation in additional studies." 1 Screening and bioinformatics analysis of circular RNA expression profiles in hepatitis B-related hepatocellular carcinoma. - - circRNA_101764 DOID:684 hepatocellular carcinoma hepatitis B virus-related hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "In this study, we comprehensively explored the expression of differentially expressed circRNAs in HBV-related HCC, and our results indicate that circRNA_101764 may play an important role in the development of HCC." 1 Effects of hsa_circRBM23 on Hepatocellular Carcinoma Cell Viability and Migration as Produced by Regulating miR-138 Expression. - hsa_circ_RBM23 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated These data indicated that upregulated circRBM23 functioned as oncogene in HCC through regulating the tumor suppressor miR-138. 2 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. hsa_circ_0034642 hsa_circ_VPS18 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" up-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 2 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. - - hsa_circ_103852 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" up-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 1 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. - - hsa_circ_101000 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" up-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 1 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. - - hsa_circ_102086 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" up-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 1 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. - - hsa_circ_100085 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" up-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 1 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. - - hsa_circ_009503 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" up-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 1 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. - - hsa_circ_103744 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" up-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 1 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. - - hsa_circ_071312 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" up-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 1 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. hsa_circ_0006240 hsa_circ_CHAF1A - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" down-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 1 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. - - hsa_circ_101481 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" down-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 1 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. - - hsa_circ_101755 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" down-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 1 Expression profile of circular RNAs in IDH-wild type glioblastoma tissues. - - hsa_circ_017051 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" down-regulated "Differential expression of circRNAs may be associated with IDH-wt glioblastoma development and progression, and these circRNAs can be identified as biomarkers for prognosis prediction and targets for treatment." 1 Circular RNA hsa_circ_0016788 regulates hepatocellular carcinoma tumorigenesis through miR-486/CDK4 pathway. hsa_circ_0016788 hsa_circ_TRIM11 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray up-regulated "In summary, results reveal the role of hsa_circ_0016788/miR-486/CDK4 in HCC tumorigenesis, providing a novel therapeutic target for HCC." 2 Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. - - hsa_circRNA_102713 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated The present study identified circRNAs in the expression profile of human gastric cancer that were potentially involved in the underlying molecular mechanisms of its development. 1 Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. - - hsa_circRNA_100924 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated The present study identified circRNAs in the expression profile of human gastric cancer that were potentially involved in the underlying molecular mechanisms of its development. 1 Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. - - hsa_circRNA_104804 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated The present study identified circRNAs in the expression profile of human gastric cancer that were potentially involved in the underlying molecular mechanisms of its development. 1 Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. - - hsa_circRNA_104707 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated The present study identified circRNAs in the expression profile of human gastric cancer that were potentially involved in the underlying molecular mechanisms of its development. 1 Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. - - hsa_circRNA_102298 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated The present study identified circRNAs in the expression profile of human gastric cancer that were potentially involved in the underlying molecular mechanisms of its development. 1 Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. - - hsa_circRNA_100911 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated The present study identified circRNAs in the expression profile of human gastric cancer that were potentially involved in the underlying molecular mechanisms of its development. 1 Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. - - hsa_circRNA_103538 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated The present study identified circRNAs in the expression profile of human gastric cancer that were potentially involved in the underlying molecular mechanisms of its development. 1 Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. - - hsa_circRNA_103477 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated The present study identified circRNAs in the expression profile of human gastric cancer that were potentially involved in the underlying molecular mechanisms of its development. 1 Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. - - hsa_circRNA_104280 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated The present study identified circRNAs in the expression profile of human gastric cancer that were potentially involved in the underlying molecular mechanisms of its development. 1 Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. - - hsa_circRNA_100144 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated The present study identified circRNAs in the expression profile of human gastric cancer that were potentially involved in the underlying molecular mechanisms of its development. 1 Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. - - hsa_circRNA_103901 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated The present study identified circRNAs in the expression profile of human gastric cancer that were potentially involved in the underlying molecular mechanisms of its development. 1 Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non-small cell lung cancer by regulating the Wnt/beta-catenin pathway. - - circ_001569 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Therefore, the results indicated that circ_001569 promoted cell proliferation by regulating the Wnt/beta-catenin pathway in NSCLC, and circ_001569 may be a potential target of NSCLC treatment." 1 Circular RNA HIPK3 promotes gallbladder cancer cell growth by sponging microRNA-124. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:3121 gallbladder cancer gallbladder cancer RT-qPCR up-regulated "At last, we show that circHIPK3 is upregulated in human gallbladder cancer tissues, which is correlated with miR-124 downregulation and ROCK1-CDK6 upregulation. Together, we conclude that circHIPK3 promotes gallbladder cancer cell growth possibly by sponging miR-124. The over-expressed circHIPK3 could be a novel therapeutic target and diagnosis marker of human gallbladder cancer." 1 CircRNA circ_0026344 as a prognostic biomarker suppresses colorectal cancer progression via microRNA-21 and microRNA-31. hsa_circ_0026344 hsa_circ_ACVRL1 circ_0026344 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "In conclusion, this study revealed that circ_0026344/miR-21/miR-31 regulatory signaling was implicated in CRC progression." 2 Preliminary investigation of the function of hsa_circ_0006215 in pancreatic cancer. hsa_circ_0006215 hsa_circ_SLC4A7 - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "The present study identified the effects of hsa_circ_0006215, miR-378a-3p and SERPINA4 signaling pathways in pancreatic cancer cells." 1 Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge. - hsa_circ_ZNF609 circular RNA-ZNF609 DOID:8466 retinal degeneration retinal neurodegeneration "RT-qPCR, RNA-seq" up-regulated "cZNF609 acted as an endogenous miR-615 sponge to sequester and inhibit miR-615 activity, which led to increased METRN. METRN overexpression could partially rescue cZNF609 silencing-mediated inhibitory effects on retinal glial cell proliferation." 1 "hsa_circ_0000729, a potential prognostic biomarker in lung adenocarcinoma." hsa_circ_0000792 hsa_circ_LOC100506779 - DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" up-regulated "We identified hsa_circ_0000792 as a potential LUAD biomarker; however, further studies are required to determine the mechanism of this circRNA in LUAD development." 1 Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke. - mmu_circ_HECTD1 - DOID:6713 cerebrovascular disease stroke microarray up-regulated "CircHECTD1 functions as an endogenous MIR142 (microRNA 142) sponge to inhibit MIR142 activity, resulting in the inhibition of TIPARP (TCDD inducible poly[ADP-ribose] polymerase) expression with subsequent inhibition of astrocyte activation via macroautophagy/autophagy." 1 Association of microRNA-7 and its binding partner CDR1-AS with the prognosis and prediction of 1(st)-line tamoxifen therapy in breast cancer. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "A negative correlation was observed between hsa-miR-7 and CDR1-AS in both cohorts. Despite associations with various clinical metrics (e.g., tumour grade, tumour size, and relapse location), CDR1-AS was neither prognostic nor predictive of relevant outcomes in our cohorts. However, we did observe stromal CDR1-AS expression, suggesting a possible cell-type specific interaction. " 2 Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7. - hsa_circ_ITGA7 - DOID:9256 colorectal cancer colorectal cancer RNA-seq down-regulated "our findings indicate a suppressor role of circITGA7 and ITGA7 in CRC, and reveal that circITGA7 inhibits the proliferation and metastasis of CRC cells by suppressing the Ras signalling pathway and promoting the transcription of ITGA7, suggesting that circITGA7 is a potential target for CRC treatment. " 4 Circ-UBR5: An exonic circular RNA and novel small nuclear RNA involved in RNA splicing. - hsa_circ_UBR5 circ-UBR5 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "Our findings indicated circ-UBR5 could bind splicing regulatory factor QKI, KH domain containing RNA binding (QKI) and NOVA alternative splicing regulator 1 (NOVA1) and U1 small nuclear RNA (snRNA) in the nucleus, revealing circ-UBR5 might be a novel snRNA involved in RNA splicing regulatory process." 1 CircHIPK3 is upregulated and predicts a poor prognosis in epithelial ovarian cancer. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:2152 ovary epithelial cancer epithelial ovarian cancer RT-qPCR up-regulated CircHIPK3 may be a novel biomarker for predicting EOC prognosis. 1 Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells. - - hg19_circ_0005033 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RNA-seq up-regulated "Moreover, our data revealed that circRNA hg19_circ_0005033 promotes proliferation, migration, invasion, and chemotherapy resistance of laryngeal cancer stem cells." 1 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0085020 hsa_circ_LAPTM4B - DOID:2116 pterygium pterygium "RT-qPCR, microarray" up-regulated "Circ_0085020 (circ-LAPTM4B) was shown as a potential biomarker for pterygium. circ_0085020 (circ-LAPTM4B) silencing affected the viability, proliferation, migration, and apoptosis of pterygium fibroblast and epithelial cells in vitro." 3 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0085019 hsa_circ_LAPTM4B - DOID:2116 pterygium pterygium "RT-qPCR, microarray" up-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 3 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0010170 hsa_circ_MFAP2 - DOID:2116 pterygium pterygium "RT-qPCR, microarray" up-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 1 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0087653 hsa_circ_CTSL2 - DOID:2116 pterygium pterygium "RT-qPCR, microarray" up-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 1 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0085013 hsa_circ_LAPTM4B - DOID:2116 pterygium pterygium "RT-qPCR, microarray" up-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 3 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0031978 hsa_circ_CDKN3 - DOID:2116 pterygium pterygium "RT-qPCR, microarray" up-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 1 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0015295 hsa_circ_GAS5 - DOID:2116 pterygium pterygium "RT-qPCR, microarray" up-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 3 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0015288 hsa_circ_GAS5 - DOID:2116 pterygium pterygium "RT-qPCR, microarray" up-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 3 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0015310 hsa_circ_GAS5 - DOID:2116 pterygium pterygium "RT-qPCR, microarray" up-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 3 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0087198 hsa_circ_GDA - DOID:2116 pterygium pterygium "RT-qPCR, microarray" down-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 1 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0025454 hsa_circ_CD69 - DOID:2116 pterygium pterygium "RT-qPCR, microarray" down-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 1 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0056159 hsa_circ_IL1RN - DOID:2116 pterygium pterygium "RT-qPCR, microarray" down-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 1 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0064840 hsa_circ_ITGA9 - DOID:2116 pterygium pterygium "RT-qPCR, microarray" down-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 1 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0034472 hsa_circ_THBS1 - DOID:2116 pterygium pterygium "RT-qPCR, microarray" down-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 1 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0009558 hsa_circ_ERRFI1 - DOID:2116 pterygium pterygium "RT-qPCR, microarray" down-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 1 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0088344 hsa_circ_STOM - DOID:2116 pterygium pterygium "RT-qPCR, microarray" down-regulated This study provides evidence that circRNAs are involved in the pathogenesis of pterygium and might constitute promising targets for the therapeutic intervention of pterygium. 1 [Experimental Research of Circular RNA hsa_circ_0000254 in Acute Myeloid Leukemia]. hsa_circ_0000254 hsa_circ_RRP12 - DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR dysregulated "The successful construction of the lentiviral expression vector pLCDH-circ254(C254) results in the production of high-titer lentivirus, so as to facilitate further study of the molecular functions of hsa_circ_0000254." 1 Characteristics of circular RNA expression in lung tissues from mice with hypoxia_induced pulmonary hypertension. - - mmu_circRNA_004592 DOID:6432 pulmonary hypertension pulmonary hypertension microarray up-regulated these dysregulated circRNAs are candidate diagnostic biomarkers and potential therapeutic targets for PH. 1 Characteristics of circular RNA expression in lung tissues from mice with hypoxia_induced pulmonary hypertension. - - mmu_circRNA_018351 DOID:6432 pulmonary hypertension pulmonary hypertension microarray down-regulated these dysregulated circRNAs are candidate diagnostic biomarkers and potential therapeutic targets for PH. 1 Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a/CRYAA axis. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:0070353 cataract age-related cataract RT-qPCR down-regulated This study suggests that circRNAs are the potential regulators in cataractogenesis. CircHIPK3 regulates HLECs function through miR-193a-mediated CRYAA expression. This finding would provide a novel insight into the pathogenesis of ARC. 3 Dysregulated circRNAs in plasma from active tuberculosis patients. - - hsa_circRNA_103571 DOID:399 tuberculosis active tuberculosis "RT-qPCR, microarray" down-regulated "Hsa_circRNA_103571 may be served as a potential biomarker for active TB diagnosis, and hsa_circRNA_103571-miRNA-mRNA interaction may provide some novel mechanism for active TB." 1 CircNT5E Acts as a Sponge of miR-422a to Promote Glioblastoma Tumorigenesis. - hsa_circ_NT5E - DOID:3073 brain glioblastoma multiforme glioblastoma microarray up-regulated Microarray profiling of circRNA/lncRNA/mRNA in glioblastoma identifies circNT5E as an oncogenic circular RNA and a sponge of miR-422a. 1 CircRNA circ-BANP-mediated miR-503/LARP1 signaling contributes to lung cancer progression. - hsa_circ_BANP circ-BANP DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "In sum, our study illustrated that circ-BANP-mediated miR-503/LARP1 signaling promoted lung cancer growth, migration and invasion, providing a novel insight on the mechanism underlying lung cancer progression." 1 A novel prognostic biomarker for pancreatic ductal adenocarcinoma: hsa_circ_0001649. hsa_circ_0001649 hsa_circ_SHPRH - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR down-regulated the results illustrated that hsa_circ_0001649 may play a tumor suppressor role in PDAC and offer a potential therapeutic target for treating this fatal disease. 1 Circ-ANAPC7 is Upregulated in Acute Myeloid Leukemia and Appears to Target the MiR-181 Family. - hsa_circ_ANAPC7 circ-ANAPC7 DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, microarray" up-regulated "These findings show that circ-ANAPC7 is a promising biomarker for AML, and that it might participate in AML pathogenesis by acting as a sponge for the miR-181 family." 2 Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells. - hsa_circ_PVRL3 - DOID:10534 stomach cancer gastric cancer microarray down-regulated "Taken together, our study indicated that down-regulation of circPVRL3 could promote the proliferation in gastric carcinoma and have potential to encode protein." 1 A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy. - hsa_circ_Dnmt1 circ-Dnmt1 DOID:1612 breast cancer breast cancer microarray up-regulated A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy. 1 Identification and Characterization of CircRNAs of Two Pig Breeds as a New Biomarker in Metabolism-Related Diseases. - - circRNA_26852 DOID:0014667 disease of metabolism metabolism-related diseases "RT-qPCR, RNA-seq" up-regulated "In this study, circRNA sequencing and bioinformatics technique were used to analyze, for the first time, the expression of circRNAs in the subcutaneous adipose tissues of Large White pig and Laiwu pig. It is inferred that circRNAs might regulate adipogenic differentiation and lipid metabolism. The results provide a theoretical basis for further study on fat deposition mechanism and provide potential therapy targets for metabolism-related diseases." 1 Identification and Characterization of CircRNAs of Two Pig Breeds as a New Biomarker in Metabolism-Related Diseases. - - circRNA_11897 DOID:0014667 disease of metabolism metabolism-related diseases "RT-qPCR, RNA-seq" down-regulated "In this study, circRNA sequencing and bioinformatics technique were used to analyze, for the first time, the expression of circRNAs in the subcutaneous adipose tissues of Large White pig and Laiwu pig. It is inferred that circRNAs might regulate adipogenic differentiation and lipid metabolism. The results provide a theoretical basis for further study on fat deposition mechanism and provide potential therapy targets for metabolism-related diseases." 1 Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma. hsa_circ_0001874 hsa_circ_BICD2 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, microarray" down-regulated This is the first study to demonstrate the potential of salivary hsa_circ_0001874 and hsa_circ_0001971 as biomarkers for the diagnosis of OSCC. 3 Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma. hsa_circ_0001971 hsa_circ_FAM126A - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, microarray" down-regulated This is the first study to demonstrate the potential of salivary hsa_circ_0001874 and hsa_circ_0001971 as biomarkers for the diagnosis of OSCC. 3 "CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8." - - circRNA8924 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8." 1 hsa_circ_0000177-miR-638-FZD7-Wnt Signaling Cascade Contributes to the Malignant Behaviors in Glioma. hsa_circ_0000177 hsa_circ_CR1 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated hsa_circ_0000177-miR-638-FZD7-Wnt Signaling Cascade Contributes to the Malignant Behaviors in Glioma. 1 Circular RNA_MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis. - hsa_circ_MTO1 hsa_circRNA-007874 DOID:1612 breast cancer breast cancer microarray down-regulated Circular RNA_MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis. 1 Decreased circular RNA hsa_circ_0001649 predicts unfavorable prognosis in glioma and exerts oncogenic properties in vitro and in vivo. hsa_circ_0001649 hsa_circ_SHPRH - DOID:0060108 brain glioma glioma RT-qPCR down-regulated "Ultimately, this study suggests that hsa_circ_0001649 may be a potential glioma-related prognostic/therapeutic target." 2 Upregulation of circular RNA hsa_circ_0007534 predicts unfavorable prognosis for NSCLC and exerts oncogenic properties in vitro and in vivo. hsa_circ_0007534 hsa_circ_DDX42 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated the present study indicates that hsa_circ_0007534 might be a potential NSCLC-associated prognostic/therapeutic target. 1 Hsa_circ_0103809 promotes cell proliferation and inhibits apoptosis in hepatocellular carcinoma by targeting miR-490-5p/SOX2 signaling pathway. hsa_circ_0103809 hsa_circ_AP4E1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Our findings suggested that hsa_circ_0103809 might facilitate HCC malignant progression, at least partially, by regulating miR-490-5p/SOX2 signaling pathway." 1 Overexpressed CDR1as functions as an oncogene to promote the tumor progression via miR-7 in non-small-cell lung cancer. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Overexpressed CDR1as in NSCLC functions promotes the tumor progression via miR-7 signals. 5 "Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer." - hsa_circ_IGHG2 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated "Comprehensive analysis indicated that the dysregulated lncRNAs and circRNAs could participate in the genesis and progression of bladder cancer. Our approach may therefore be valuable for detecting novel transcripts, discovering new biomarkers for bladder cancer and expounding the pathogenic mechanisms of this disease." 1 "Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer." hsa_circ_0138896 hsa_circ_PGM5 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "Comprehensive analysis indicated that the dysregulated lncRNAs and circRNAs could participate in the genesis and progression of bladder cancer. Our approach may therefore be valuable for detecting novel transcripts, discovering new biomarkers for bladder cancer and expounding the pathogenic mechanisms of this disease." 1 "Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer." hsa_circ_0018069 hsa_circ_KIAA1462 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "Comprehensive analysis indicated that the dysregulated lncRNAs and circRNAs could participate in the genesis and progression of bladder cancer. Our approach may therefore be valuable for detecting novel transcripts, discovering new biomarkers for bladder cancer and expounding the pathogenic mechanisms of this disease." 1 Circular RNA circ_0001649 acts as a prognostic biomarker and inhibits NSCLC progression via sponging miR-331-3p and miR-338-5p. - - circ_0001649 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "Collectively, this study suggested that circ_0001649/miR-331-3p/miR-338-5p regulatory signaling might be a potential target for NSCLC therapy." 1 Role of Circular RNA DLEU2 in Human Acute Myeloid Leukemia. - hsa_circ_DLEU2 circRNA-DLEU2 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated CircRNA-DLEU2 accelerated human AML by suppressing miR-496 and promoting PRKACB expression. 2 circFBLIM1 act as a ceRNA to promote hepatocellular cancer progression by sponging miR-346. - hsa_circ_FBLIM1 - DOID:687 hepatoblastoma hepatoblastoma "RT-qPCR, microarray" up-regulated "Taken together, we conclude that circFBLIM1 may function as a competing endogenous RNA (ceRNA) to regulate FBLIM1 expression through sponging miR-346 to exert regulatory functions in HCC. circFBLIM1 may be a diagnostic biomarker and potential target for HCC therapy." 1 Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR-185/TGF-beta1. - - circRNA_15698 DOID:557 kidney disease diabetic nephropathy microarray up-regulated "In summary, our study preliminarily investigates the role of circRNAs in mesangial cells and ECM accumulation, providing a novel insight for DN pathogenesis." 1 CircRNA circHIPK3 serves as a prognostic marker to promote glioma progression by regulating miR-654/IGF2BP3 signaling. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated our findings demonstrated that circHIPK3 contributes to glioma progression through targeting miR-654 from IGF2BP3 and implies circHIPK3 might be a potential target for glioma therapy. 7 Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targetting miR-532-5p. hsa_circ_0000673 hsa_circ_RSL1D1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated The present study showed that hsa_circ_0000673 was decreased in GC and it exerted tumor-suppressing effects by targetting miR-532-5p and up-regulating RUNX3 expression level. Hsa_circ_0000673 may be a promising diagnosis biomarker and therapeutic target in GC. 1 Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis. - hsa_circ_IARS circ-IARS DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "Circ-IRAS accesses HUVECs via exosomes derived from pancreatic cancer cells followed by increased endothelial monolayer permeability. Furthermore, this process promotes tumor invasion and metastasis. The results of this study suggest that the presence of circRNAs in exosomes may be important indicator for early diagnosis and prognostic prediction in PDAC." 1 Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus. - hsa_circ_ANKRD36 - DOID:9352 type 2 diabetes mellitus type 2 diabetes mellitus "RT-qPCR, RNA-seq" up-regulated "The expression of circANKRD36 was up-regulated in peripheral blood leucocytes and was correlated with chronic inflammation in T2DM. Therefore, circANKRD36 can be used as a potential biomarker for screening chronic inflammation in patients with T2DM." 1 Competing endogenous RNA analysis reveals the regulatory potency of circRNA_036186 in HNSCC. - - circRNA_036186 DOID:5520 head and neck squamous cell carcinoma head and neck squamous cell carcinoma "RT-qPCR, microarray" up-regulated These findings suggest that circRNA_036186 likely regulates 14_3_3¦Ć expression by functioning as a ceRNA in the development and progression of HNSCC. 1 Regulatory network of circRNA-miRNA-mRNA contributes to the histological classification and disease progression in gastric cancer. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated The targets of circHIPK3-miR-124/miR-29b axes involved in the progression of GC. CircHIPK3 could take part in the proliferation process of GC cell and may be potential biomarker in histological classification of GC. 6 Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma. - - hsa_circ_001242 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated This study showed that hsa_circ_001242 was significantly downregulated in OSCC and may act as a potential novel biomarker for the diagnosis and treatment of OSCC. 1 CircHIPK3 promotes proliferation and invasion in nasopharyngeal carcinoma by abrogating miR-4288-induced ELF3 inhibition. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "The circHIPK3 facilitated NPC progression through protecting ELF3 from miR-4288-mediated silencing, which suggested that the circHIPK3-miR-4288-ELF3 regulatory loop might be a potential target for NPC prevention." 3 Microarray Analysis of Differentially Expressed Profiles of Circular RNAs in a Mouse Model of Intestinal Ischemia/Reperfusion Injury with and Without Ischemic Postconditioning. - rno_circ_Rn45s circRNA_012412 DOID:936 brain disease ischemia reperfusion injury "RT-qPCR, microarray" up-regulated This study was the first to comprehensively delineate the expression profiles of circRNAs in a mouse model of intestinal I/R and iPoC and provides novel clues for understanding the mechanisms of iPoC against intestinal I/R injury. 2 Microarray Analysis of Differentially Expressed Profiles of Circular RNAs in a Mouse Model of Intestinal Ischemia/Reperfusion Injury with and Without Ischemic Postconditioning. - rno_circ_Rn45s circRNA_016863 DOID:936 brain disease ischemia reperfusion injury "RT-qPCR, microarray" up-regulated This study was the first to comprehensively delineate the expression profiles of circRNAs in a mouse model of intestinal I/R and iPoC and provides novel clues for understanding the mechanisms of iPoC against intestinal I/R injury. 2 Circular RNA ciRS-7 Maintains Metastatic Phenotypes as a ceRNA of miR-1299 to Target MMPs. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "Circular RNA ciRS-7 is highly expressed in TNBC tumor specimens and cells, and its downregulation inhibits cell migration and invasion of TNBC cells in vitro and in vivo In addition, ciRS-7 functions as a ceRNA of miR-1299 to enhance the expression of MMPs, which maintains the high migration and invasion properties of TNBC cells." 1 NFIX Circular RNA Promotes Glioma Progression by Regulating miR-34a-5p via Notch Signaling Pathway. - hsa_circ_NFIX - DOID:0060108 brain glioma glioma RT-qPCR up-regulated CircNFIX was markedly upregulated in glioma cells. CircNFIX could regulate NOTCH1 and the Notch signaling pathway to promote glioma progression by sponging miR-34a-5p via the Notch signaling pathway. This finding provided a deeper insight into the function of circNFIX in human glioma cancer progression. 2 [Circular RNA circHIPK3 acts as the sponge of microRNA-124 to promote human oral squamous cell carcinoma cells proliferation]. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated Our results suggest that circHIPK3 may play a key role in the occurrence and development process of OSCC through the regulation of miR-124 expression. 3 CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated our findings demonstrate how ciRS-7 induces malignant progression of ESCC and that ciRS-7 may act as a novel prognostic marker and therapeutic target for this lethal disease. 4 circEPSTI1 as a Prognostic Marker and Mediator of Triple-Negative Breast Cancer Progression. - hsa_circ_EPSTI1 circRNA_000479 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer microarray up-regulated "The circEPSTI1-miR-4753/6809-BCL11A axis affect the proliferation and apoptosis of triple-negative breast cancer through the mechanism of competing endogenous RNAs (ceRNA). In addition, our results identify circEPSTI1 as an independent prognostic marker for survival in patients with TNBC." 1 Upregulated hsa_circ_0004458 Contributes to Progression of Papillary Thyroid Carcinoma by Inhibition of miR-885-5p and Activation of RAC1. hsa_circ_0004458 hsa_circ_PSD3 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "We found that hsa_circ_0004458 promoted the progression of PTC by inhibition of miR-885-5p and activation of RAC1, and hsa_circ_0004458 may serve as a potential therapeutic target and biomarker for PTC." 5 Overexpression of circular RNA circ_001569 indicates poor prognosis in hepatocellular carcinoma and promotes cell growth and metastasis by sponging miR-411-5p and miR-432-5p. - - circ_001569 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "In summary, circ_001569/miR-411-5p/miR-432-5p regulatory signaling might be a rational HCC-related therapeutic target." 1 Profiles of differentially expressed circRNAs in esophageal and breast cancer. - - hsa_circRNA_103670 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RNA-seq up-regulated "We observed 469 upregulated circRNAs and 275 downregulated circRNAs in ESCC. Hsa_circRNA_103670 was upregulated 20.3-fold, while hsa_circRNA_030162 was downregulated 12.1-fold. For BC, 715 circRNAs were upregulated, and 440 circRNAs were downregulated. Hsa_circRNA_005230 was upregulated 12.2-fold, while hsa_circRNA_406225 was downregulated 12.4-fold." 1 Profiles of differentially expressed circRNAs in esophageal and breast cancer. - - hsa_circRNA_030162 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RNA-seq down-regulated "We observed 469 upregulated circRNAs and 275 downregulated circRNAs in ESCC. Hsa_circRNA_103670 was upregulated 20.3-fold, while hsa_circRNA_030162 was downregulated 12.1-fold. For BC, 715 circRNAs were upregulated, and 440 circRNAs were downregulated. Hsa_circRNA_005230 was upregulated 12.2-fold, while hsa_circRNA_406225 was downregulated 12.4-fold." 1 Profiles of differentially expressed circRNAs in esophageal and breast cancer. - - hsa_circRNA_005230 DOID:1612 breast cancer breast cancer RNA-seq up-regulated "We observed 469 upregulated circRNAs and 275 downregulated circRNAs in ESCC. Hsa_circRNA_103670 was upregulated 20.3-fold, while hsa_circRNA_030162 was downregulated 12.1-fold. For BC, 715 circRNAs were upregulated, and 440 circRNAs were downregulated. Hsa_circRNA_005230 was upregulated 12.2-fold, while hsa_circRNA_406225 was downregulated 12.4-fold." 1 Profiles of differentially expressed circRNAs in esophageal and breast cancer. - - hsa_circRNA_406225 DOID:1612 breast cancer breast cancer RNA-seq down-regulated "We observed 469 upregulated circRNAs and 275 downregulated circRNAs in ESCC. Hsa_circRNA_103670 was upregulated 20.3-fold, while hsa_circRNA_030162 was downregulated 12.1-fold. For BC, 715 circRNAs were upregulated, and 440 circRNAs were downregulated. Hsa_circRNA_005230 was upregulated 12.2-fold, while hsa_circRNA_406225 was downregulated 12.4-fold." 1 CircularRNA_104670 plays a critical role in intervertebral disc degeneration by functioning as a ceRNA. - - circRNA_104670 DOID:90 degenerative disc disease intervertebral disc degeneration microarray up-regulated CircRNA_104670 is highly expressed in the NP tissues of IDD and acts as a ceRNA during NP degradation. 1 A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma. hsa_circ_0004913 hsa_circ_TEX2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated Our study provides a novel insight into the pathogenesis and therapy of HCC from the circRNA-miRNA-mRNA network view. 3 A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma. hsa_circ_0002980 hsa_circ_AGK - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated Our study provides a novel insight into the pathogenesis and therapy of HCC from the circRNA-miRNA-mRNA network view. 1 A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma. hsa_circ_0000098 hsa_circ_SLC30A7 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated Our study provides a novel insight into the pathogenesis and therapy of HCC from the circRNA-miRNA-mRNA network view. 4 Downregulation of circular RNA hsa_circ_0000144 inhibits bladder cancer progression via stimulating miR-217 and suppressing RUNX2 expression. hsa_circ_0000144 hsa_circ_SLAMF6 - DOID:11054 urinary bladder cancer bladder cancer RNA-seq up-regulated these findings demonstrated that hsa_circ_0000144 exerts oncogenic roles in bladder cancer via repressing miR-217 to facilitate RUNX2 expression. 1 Silencing of circRNA2837 Plays a Protective Role in Sciatic Nerve Injury by Sponging the miR-34 Family via Regulating Neuronal Autophagy. - - circRNA.2837 DOID:11446 sciatic neuropathy sciatic nerve injury "RT-qPCR, RNA-seq" down-regulated "Our findings suggested that differentially expressed circular RNAs were involved in the pathogenesis of sciatic nerve injury, and circular RNAs exerted regulatory functions in sciatic nerve injury and might be used as potential targets in sciatic nerve injury therapy." 1 Circ-BPTF promotes bladder cancer progression and recurrence through the miR-31-5p/RAB27A axis. hsa_circ_0000799 hsa_circ_BPTF circ-BPTF DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "our findings reveal that circ-BPTF promotes BCa progression through the miR-31-5p/RAB27A axis, suggesting that circ-BPTF may be a potential target for BCa treatment." 1 Upregulated circular RNA circ_0016760 indicates unfavorable prognosis in NSCLC and promotes cell progression through miR-1287/GAGE1 axis. hsa_circ_0016760 hsa_circ_SNAP47 circ_0016760 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0016760/miR-1287/GAGE1 signaling might play vital roles in the tumorigenesis and progression of NSCLC. 6 Circular RNA Complement Factor H (CFH) Promotes Glioma Progression by Sponging miR-149 and Regulating AKT1. hsa_circ_0015758 hsa_circ_CFH circular RNA Complement Factor H (CFH) DOID:0060108 brain glioma glioma RT-qPCR up-regulated Circ-CFH promotes glioma progression by sponging miR-149 and regulating the AKT1 signaling pathway. The circ-CFH/miR-149/AKT1 regulation axis may be a potential target for glioma therapy. 1 [Differentially expressed circular RNAs in human gastric cancer cells]. hsa_circ_0001897 hsa_circ_POMT1 - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The above results suggest that hsa_circ_0001897, hsa_circ_0008106 and hsa_circ_0060456 may be closely related to the occurrence and development of gastric cancer by interacting with miRNA." 2 [Differentially expressed circular RNAs in human gastric cancer cells]. hsa_circ_0008106 hsa_circ_LRCH3 - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The above results suggest that hsa_circ_0001897, hsa_circ_0008106 and hsa_circ_0060456 may be closely related to the occurrence and development of gastric cancer by interacting with miRNA." 2 [Differentially expressed circular RNAs in human gastric cancer cells]. hsa_circ_0060456 hsa_circ_MYBL2 - DOID:10534 stomach cancer gastric cancer microarray up-regulated "The above results suggest that hsa_circ_0001897, hsa_circ_0008106 and hsa_circ_0060456 may be closely related to the occurrence and development of gastric cancer by interacting with miRNA." 2 Global microarray profiling identified hsa_circ_0064428 as a potential immune-associated prognosis biomarker for hepatocellular carcinoma. hsa_circ_0064428 hsa_circ_SLC6A6 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated These findings together imply that_sa_circ_0064428_ould be considered as a potential HCC prognosis biomarker. Future in-depth research is required to further illustrate the involvement of_sa_circ_0064428_n HCC tumourigenesis and metastasis. 1 Circ-ZEB133 promotes the proliferation of human HCC by sponging miR-200a-3p and upregulating CDK6. - hsa_circ_ZEB1.33 circ-ZEB1.33 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Proliferation promotion roles of the circ-ZEB1.33-miR-200a-3p-CDK6 regulating axis are existed and verified in human HCC, both tumor and serum circ-ZEB1.33 can serve as an indicator for the prognosis of HCC patients." 1 Profile and clinical implication of circular RNAs in human papillary thyroid carcinoma. - - hsa_circRNA_047771 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR down-regulated The most up and downregulated circRNAs were hsa_circRNA_007148 and hsa_circRNA_047771. 1 Profile and clinical implication of circular RNAs in human papillary thyroid carcinoma. - - hsa_circRNA_007148 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated The most up and downregulated circRNAs were hsa_circRNA_007148 and hsa_circRNA_047771. 1 Comprehensive analysis of the whole coding and non-coding RNA transcriptome expression profiles and construction of the circRNA-lncRNA co-regulated ceRNA network in laryngeal squamous cell carcinoma. hsa_circ_0033988 hsa_circ_LINC00221 - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "Hsa_circ_0033988 with the highest degree in the circRNA-mediated ceRNA network was associated with fatty acid degradation, which was responsible for the depletion of fat in tumor-associated cachexia." 1 Circ_0056618 and CXCR4 act as competing endogenous in gastric cancer by regulating miR-206. hsa_circ_0056618 - circ_0056618 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_0056618 and CXCR4 act as competing endogenous in gastric cancer by regulating miR-206. 1 CircRBMS3 promotes gastric cancer tumorigenesis by regulating miR-153-SNAI1 axis. - hsa_circ_RBMS3 circRBMS3 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated The circRBMS3 promoted GC cells proliferation and invasion via regulating miR-153/SNAI1 axis. 1 Circular RNA CEP128 acts as a sponge of miR-145-5p in promoting the bladder cancer progression via regulating SOX11. - hsa_circ_CEP128 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "CircCEP128 functions as a ceRNA for miR-145-5p, which could up regulates SOX11 and further promotes cell proliferation and inhibits cell apoptosis of bladder cancer." 2 MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells. - hsa_circ_MAP2K4 hsa_circRNA_101981 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Overexpression of miR-145 promoted the expression of hsa_circRNA_101981, hsa_circRNA_008068, and hsa_circRNA_406557 but_uppressed the expressions of hsa_circRNA_101996 and hsa_circRNA_091420 in prostate cancer LNCaP cells." 1 MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells. - hsa_circ_KATNAL1 hsa_circRNA_008068 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Overexpression of miR-145 promoted the expression of hsa_circRNA_101981, hsa_circRNA_008068, and hsa_circRNA_406557 but_uppressed the expressions of hsa_circRNA_101996 and hsa_circRNA_091420 in prostate cancer LNCaP cells." 2 MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells. - hsa_circ_RAPGEF2 hsa_circRNA_406557 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Overexpression of miR-145 promoted the expression of hsa_circRNA_101981, hsa_circRNA_008068, and hsa_circRNA_406557 but_uppressed the expressions of hsa_circRNA_101996 and hsa_circRNA_091420 in prostate cancer LNCaP cells." 1 MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells. - hsa_circ_SPECC1 hsa_circRNA_101996 DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated "Overexpression of miR-145 promoted the expression of hsa_circRNA_101981, hsa_circRNA_008068, and hsa_circRNA_406557 but_uppressed the expressions of hsa_circRNA_101996 and hsa_circRNA_091420 in prostate cancer LNCaP cells." 1 MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells. - hsa_circ_RPL39 hsa_circRNA_091420 DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated "Overexpression of miR-145 promoted the expression of hsa_circRNA_101981, hsa_circRNA_008068, and hsa_circRNA_406557 but_uppressed the expressions of hsa_circRNA_101996 and hsa_circRNA_091420 in prostate cancer LNCaP cells." 1 Aberrant expression of hsa_circ_0025036 in lung adenocarcinoma and its potential roles in regulating cell proliferation and apoptosis. hsa_circ_0025036 hsa_circ_FOXM1 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "In conclusion, we demonstrate that hsa_circ_0025036 regulates cell proliferation and apoptosis in lung adenocarcinoma cells probably via hsa_circ_0025036/miR-198/SHMT1&TGF-alpha axis. hsa_circ_0025036 may serve as a potential prognostic biomarker and a therapeutic target for lung adenocarcinoma." 1 Downregulation of hsa_circ_0007534 suppresses breast cancer cell proliferation and invasion by targeting miR-593/MUC19 signal pathway. hsa_circ_0007534 hsa_circ_DDX42 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Our findings suggest an oncogenic role for hsa_circ_0007534 in BC by acting as a miR-593 sponge to promote MUC19 expression. 1 Overexpression of hsa_circ_0007534 predicts unfavorable prognosis for osteosarcoma and regulates cell growth and apoptosis by affecting AKT/GSK-3beta signaling pathway. hsa_circ_0007534 hsa_circ_DDX42 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "hsa_circ_0007534 protects against cell apoptosis via Bcl-2/caspase-3 pathway. Furthermore, AKT/GSK-3beta pathway could be activated by hsa_circ_0007534 to facilitate OS progression." 2 Circular RNA circ-VANGL1 as a competing endogenous RNA contributes to bladder cancer progression by regulating miR-605-3p/VANGL1 pathway. - hsa_circ_VANGL1 circ-VANGL1 DOID:11054 urinary bladder cancer bladder cancer microarray up-regulated The circ-VANGL1/miR-605-3p/VANGL1 as a novel essential signaling pathway involved in BC progression. 3 The expression profile and clinical application potential of hsa_circ_0000711 in colorectal cancer. hsa_circ_0000711 hsa_circ_NFATC3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated All of these results indicated that hsa_circ_0000711 may play a crucial role in CRC carcinogenesis and could be a potential effective biomarker for the diagnosis and prognosis of CRC. 3 Circular DNA tumor viruses make circular RNAs. - hsa_circ_vIRF4 - DOID:162 cancer gammaherpesvirus-related tumors RNA-seq up-regulated The circRNAs are a new class of viral transcripts expressed in gammaherpesvirus-related tumors that might contribute to viral oncogenesis. 1 Circular DNA tumor viruses make circular RNAs. - hsa_circ_PANs - DOID:162 cancer gammaherpesvirus-related tumors RNA-seq up-regulated The circRNAs are a new class of viral transcripts expressed in gammaherpesvirus-related tumors that might contribute to viral oncogenesis. 1 Circular RNA of vimentin expression as a valuable predictor for acute myeloid leukemia development and prognosis. - hsa_circ_VIM circ-VIM DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated Circ-VIM could serve as a significant biomarker. 1 "Circular RNAs hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 are predicted to promote CADM1 expression by functioning as miRNAs sponge in human osteosarcoma." hsa_circ_0032462 hsa_circ_SIPA1L1 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated "We envision this discovery of these important moleculars, incuding hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 and CADM1 may lead to further development of new concepts, thus allowing for more opportunities in diagnosis and therapy of OS." 3 "Circular RNAs hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 are predicted to promote CADM1 expression by functioning as miRNAs sponge in human osteosarcoma." hsa_circ_0028173 hsa_circ_ATP2A2 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated "We envision this discovery of these important moleculars, incuding hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 and CADM1 may lead to further development of new concepts, thus allowing for more opportunities in diagnosis and therapy of OS." 2 "Circular RNAs hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 are predicted to promote CADM1 expression by functioning as miRNAs sponge in human osteosarcoma." hsa_circ_0005909 hsa_circ_XPR1 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated "We envision this discovery of these important moleculars, incuding hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 and CADM1 may lead to further development of new concepts, thus allowing for more opportunities in diagnosis and therapy of OS." 2 "Circ008913, via miR-889 regulation of DAB2IP/ZEB1, is involved in the arsenite-induced acquisition of CSC-like properties by human keratinocytes in carcinogenesis." - - circ008913 DOID:162 cancer cancer RNA-seq down-regulated "These results suggest that, in HaCaT cells, arsenite decreases circ008913 levels, which act as a sponge for miR-889 and down-regulate the miR-889 target, DAB2IP, which, in turn, up-regulates ZEB1, increases mRNA levels of the cell-surface markers of skin stem cells, and is involved in arsenite-induced acquisition of CSC-like properties that lead to malignant transformation." 1 Network analyses-based identification of circular ribonucleic acid-related pathways in intrahepatic cholangiocarcinoma. - - circ2174 DOID:4947 cholangiocarcinoma cholangiocarcinoma RNA-seq up-regulated "These data suggest a mechanism whereby circ2174 can act as a sponge to regulate the expression of miR149, and thereby modulate Oct-2 and interleukin-16 signaling pathways in cholangiocarcinoma." 1 Using plasma circRNA_002453 as a novel biomarker in the diagnosis of lupus nephritis. - - circRNA_002453 DOID:0080162 lupus nephritis lupus nephritis RT-qPCR up-regulated This study suggests that upregulated plasma circRNA_002453 level in LN patients is associated with the severity of renal involvement and may also serve as a potential biomarker for LN patient diagnosis. 1 CircRNA_100290 promotes colorectal cancer progression through miR-516b-induced downregulation of FZD4 expression and Wnt/beta-catenin signaling. - - circRNA_100290 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated CircRNA_100290 promotes colorectal cancer progression through miR-516b-induced downregulation of FZD4 expression and Wnt/beta-catenin signaling. 1 CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression. - - hsa_circ_100395 DOID:1324 lung cancer lung cancer RT-qPCR down-regulated CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression. 1 CDR1as is overexpressed in laryngeal squamous cell carcinoma to promote the tumour progression via miR-7 signals. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated CDR1as is an oncogene that promotes LSCC progression by regulating miR-7 signals. 1 Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma. - - mmu_circRNA_000287 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "Our study revealed a comprehensive expression and functional profile for differentially expressed circRNAs in AOM/DSS induced colon carcinogenesis, indicating possible involvement of these dysregulated circRNAs in the development of colitis-induced colon carcinoma." 1 Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma. - - mmu_circRNA_003037 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "Our study revealed a comprehensive expression and functional profile for differentially expressed circRNAs in AOM/DSS induced colon carcinogenesis, indicating possible involvement of these dysregulated circRNAs in the development of colitis-induced colon carcinoma." 1 Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma. - - mmu_circRNA_001226 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "Our study revealed a comprehensive expression and functional profile for differentially expressed circRNAs in AOM/DSS induced colon carcinogenesis, indicating possible involvement of these dysregulated circRNAs in the development of colitis-induced colon carcinoma." 1 Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma. - - mmu_circRNA_001801 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "Our study revealed a comprehensive expression and functional profile for differentially expressed circRNAs in AOM/DSS induced colon carcinogenesis, indicating possible involvement of these dysregulated circRNAs in the development of colitis-induced colon carcinoma." 1 Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma. - - mmu_circRNA_002987 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "Our study revealed a comprehensive expression and functional profile for differentially expressed circRNAs in AOM/DSS induced colon carcinogenesis, indicating possible involvement of these dysregulated circRNAs in the development of colitis-induced colon carcinoma." 1 Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma. - - mmu_circRNA_001155 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "Our study revealed a comprehensive expression and functional profile for differentially expressed circRNAs in AOM/DSS induced colon carcinogenesis, indicating possible involvement of these dysregulated circRNAs in the development of colitis-induced colon carcinoma." 1 Circular RNA hsa_circ_0072995 promotes breast cancer cell migration and invasion through sponge for miR-30c-2-3p. hsa_circ_0072995 hsa_circ_RGNEF - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circular RNA hsa_circ_0072995 promotes breast cancer cell migration and invasion through sponge for miR-30c-2-3p. 1 [Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells]. - - hsa_circRNA_061260 DOID:0060548 luminal breast carcinoma A luminal breast cancer "RT-qPCR, microarray" up-regulated "Nine circRNAs showed differential expressions by more than 2 folds, including 8 up-regulated ones, namely hsa_circRNA_061260 (6.02 folds), hsa_circRNA_103933 (5.96 folds), hsa_circRNA_005239 (5.84 folds), hsa_circRNA_100689 (5.69 folds), hsa_circRNA_004087 (5.60 folds), hsa_circRNA_104420 (5.25 folds), hsa_circRNA_104421 (5.13 folds) and hsa_circRNA_101222 (5.03 folds); only one circRNA was down-regulated, namely hsa_circRNA_104864 (5.09 folds). The expressions of hsa_circRNA_100689, hsa_circRNA_005239 and hsa_circRNA_104864 were further validated by qPCR, which yielded consistent results with the microarray data." 1 [Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells]. - - hsa_circRNA_103933 DOID:0060548 luminal breast carcinoma A luminal breast cancer "RT-qPCR, microarray" up-regulated "Nine circRNAs showed differential expressions by more than 2 folds, including 8 up-regulated ones, namely hsa_circRNA_061260 (6.02 folds), hsa_circRNA_103933 (5.96 folds), hsa_circRNA_005239 (5.84 folds), hsa_circRNA_100689 (5.69 folds), hsa_circRNA_004087 (5.60 folds), hsa_circRNA_104420 (5.25 folds), hsa_circRNA_104421 (5.13 folds) and hsa_circRNA_101222 (5.03 folds); only one circRNA was down-regulated, namely hsa_circRNA_104864 (5.09 folds). The expressions of hsa_circRNA_100689, hsa_circRNA_005239 and hsa_circRNA_104864 were further validated by qPCR, which yielded consistent results with the microarray data." 1 [Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells]. - - hsa_circRNA_005239 DOID:0060548 luminal breast carcinoma A luminal breast cancer "RT-qPCR, microarray" up-regulated "Nine circRNAs showed differential expressions by more than 2 folds, including 8 up-regulated ones, namely hsa_circRNA_061260 (6.02 folds), hsa_circRNA_103933 (5.96 folds), hsa_circRNA_005239 (5.84 folds), hsa_circRNA_100689 (5.69 folds), hsa_circRNA_004087 (5.60 folds), hsa_circRNA_104420 (5.25 folds), hsa_circRNA_104421 (5.13 folds) and hsa_circRNA_101222 (5.03 folds); only one circRNA was down-regulated, namely hsa_circRNA_104864 (5.09 folds). The expressions of hsa_circRNA_100689, hsa_circRNA_005239 and hsa_circRNA_104864 were further validated by qPCR, which yielded consistent results with the microarray data." 1 [Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells]. - - hsa_circRNA_100689 DOID:0060548 luminal breast carcinoma A luminal breast cancer "RT-qPCR, microarray" up-regulated "Nine circRNAs showed differential expressions by more than 2 folds, including 8 up-regulated ones, namely hsa_circRNA_061260 (6.02 folds), hsa_circRNA_103933 (5.96 folds), hsa_circRNA_005239 (5.84 folds), hsa_circRNA_100689 (5.69 folds), hsa_circRNA_004087 (5.60 folds), hsa_circRNA_104420 (5.25 folds), hsa_circRNA_104421 (5.13 folds) and hsa_circRNA_101222 (5.03 folds); only one circRNA was down-regulated, namely hsa_circRNA_104864 (5.09 folds). The expressions of hsa_circRNA_100689, hsa_circRNA_005239 and hsa_circRNA_104864 were further validated by qPCR, which yielded consistent results with the microarray data." 1 [Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells]. - - hsa_circRNA_004087 DOID:0060548 luminal breast carcinoma A luminal breast cancer "RT-qPCR, microarray" up-regulated "Nine circRNAs showed differential expressions by more than 2 folds, including 8 up-regulated ones, namely hsa_circRNA_061260 (6.02 folds), hsa_circRNA_103933 (5.96 folds), hsa_circRNA_005239 (5.84 folds), hsa_circRNA_100689 (5.69 folds), hsa_circRNA_004087 (5.60 folds), hsa_circRNA_104420 (5.25 folds), hsa_circRNA_104421 (5.13 folds) and hsa_circRNA_101222 (5.03 folds); only one circRNA was down-regulated, namely hsa_circRNA_104864 (5.09 folds). The expressions of hsa_circRNA_100689, hsa_circRNA_005239 and hsa_circRNA_104864 were further validated by qPCR, which yielded consistent results with the microarray data." 1 [Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells]. - - hsa_circRNA_104420 DOID:0060548 luminal breast carcinoma A luminal breast cancer "RT-qPCR, microarray" up-regulated "Nine circRNAs showed differential expressions by more than 2 folds, including 8 up-regulated ones, namely hsa_circRNA_061260 (6.02 folds), hsa_circRNA_103933 (5.96 folds), hsa_circRNA_005239 (5.84 folds), hsa_circRNA_100689 (5.69 folds), hsa_circRNA_004087 (5.60 folds), hsa_circRNA_104420 (5.25 folds), hsa_circRNA_104421 (5.13 folds) and hsa_circRNA_101222 (5.03 folds); only one circRNA was down-regulated, namely hsa_circRNA_104864 (5.09 folds). The expressions of hsa_circRNA_100689, hsa_circRNA_005239 and hsa_circRNA_104864 were further validated by qPCR, which yielded consistent results with the microarray data." 1 [Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells]. - - hsa_circRNA_104421 DOID:0060548 luminal breast carcinoma A luminal breast cancer "RT-qPCR, microarray" up-regulated "Nine circRNAs showed differential expressions by more than 2 folds, including 8 up-regulated ones, namely hsa_circRNA_061260 (6.02 folds), hsa_circRNA_103933 (5.96 folds), hsa_circRNA_005239 (5.84 folds), hsa_circRNA_100689 (5.69 folds), hsa_circRNA_004087 (5.60 folds), hsa_circRNA_104420 (5.25 folds), hsa_circRNA_104421 (5.13 folds) and hsa_circRNA_101222 (5.03 folds); only one circRNA was down-regulated, namely hsa_circRNA_104864 (5.09 folds). The expressions of hsa_circRNA_100689, hsa_circRNA_005239 and hsa_circRNA_104864 were further validated by qPCR, which yielded consistent results with the microarray data." 1 [Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells]. - - hsa_circRNA_101222 DOID:0060548 luminal breast carcinoma A luminal breast cancer "RT-qPCR, microarray" up-regulated "Nine circRNAs showed differential expressions by more than 2 folds, including 8 up-regulated ones, namely hsa_circRNA_061260 (6.02 folds), hsa_circRNA_103933 (5.96 folds), hsa_circRNA_005239 (5.84 folds), hsa_circRNA_100689 (5.69 folds), hsa_circRNA_004087 (5.60 folds), hsa_circRNA_104420 (5.25 folds), hsa_circRNA_104421 (5.13 folds) and hsa_circRNA_101222 (5.03 folds); only one circRNA was down-regulated, namely hsa_circRNA_104864 (5.09 folds). The expressions of hsa_circRNA_100689, hsa_circRNA_005239 and hsa_circRNA_104864 were further validated by qPCR, which yielded consistent results with the microarray data." 1 [Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells]. - - hsa_circRNA_104864 DOID:0060548 luminal breast carcinoma A luminal breast cancer "RT-qPCR, microarray" down-regulated "Nine circRNAs showed differential expressions by more than 2 folds, including 8 up-regulated ones, namely hsa_circRNA_061260 (6.02 folds), hsa_circRNA_103933 (5.96 folds), hsa_circRNA_005239 (5.84 folds), hsa_circRNA_100689 (5.69 folds), hsa_circRNA_004087 (5.60 folds), hsa_circRNA_104420 (5.25 folds), hsa_circRNA_104421 (5.13 folds) and hsa_circRNA_101222 (5.03 folds); only one circRNA was down-regulated, namely hsa_circRNA_104864 (5.09 folds). The expressions of hsa_circRNA_100689, hsa_circRNA_005239 and hsa_circRNA_104864 were further validated by qPCR, which yielded consistent results with the microarray data." 1 CircRNA circ-ITCH suppresses papillary thyroid cancer progression through miR-22-3p/CBL/beta-catenin pathway. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR down-regulated "In summary, our study reveals a novel signaling pathway of circ-ITCH/miR-22-3p/CBL/beta-catenin involved in PTC development and progression." 1 Screening circular RNA related to chemotherapeutic resistance in osteosarcoma by RNA sequencing. hsa_circ_0004674 hsa_circ_ADAM22 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated CircRNAs may play a role in OS chemoresistance and hsa_circ_0004674 might be a candidate target. 2 The Circular RNA ciRs-126 Predicts Survival in Critically Ill Patients With Acute Kidney Injury. hsa_circ_0003266 hsa_circ_LRIG1 ciRs-126 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated Circulating concentrations of circRNAs in patients with AKI are detectable. ciRs-126 may potentially sponge miR-126-5p and acts as a predictor of mortality in this patient cohort. 1 The CDR1as/miR-7/TGFBR2 Axis Modulates EMT in Silica-Induced Pulmonary Fibrosis. hsa_circ_0001946 rno_circ_CDR1 "ciRS-7, CDR1as" DOID:0050156 idiopathic pulmonary fibrosis silica-induced pulmonary fibrosis RT-qPCR up-regulated "CircRNA CDR1as stimulated by silica could sponge miR-7 to release TGFBR2, plays an important role during pulmonary fibrosis by promoting EMT process." 1 Global identification of circular RNAs in chronic myeloid leukemia reveals hsa_circ_0080145 regulates cell proliferation by sponging miR-29b. hsa_circ_0080145 hsa_circ_TNS3 - DOID:8552 chronic myeloid leukemia chronic myeloid leukemia RNA-seq up-regulated functional experiments demonstrated that hsa_circ_0080145 knockdown significantly suppressed CML cell proliferation and hsa_circ_0080145 regulated CML cell proliferation by acting as an miR-29b sponge. 3 Circular RNA ciRS-7 triggers the migration and invasion of esophageal squamous cell carcinoma via miR-7/KLF4 and NF-kappaB signals. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated Our present study revealed that ciRS-7 can trigger the migration and invasion of ESCC cells via miR-7/KLF4 and NF-¦ĘB signals. Targeted inhibition of ciRS-7 might be a potential approach for ESCC treatment. 4 Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway. - hsa_circ_NEK6 - DOID:1781 thyroid gland cancer thyroid cancer "RT-qPCR, microarray" up-regulated CircNEK6 promoted the progression of thyroid cancer through up-regulating FZD8 and activating Wnt signaling pathway by targeting miR-370-3p. 1 A novel circular RNA hsa_circ_0020123 exerts oncogenic properties through suppression of miR-144 in non-small cell lung cancer. hsa_circ_0020123 hsa_circ_PDZD8 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated "the hsa_circ_0020123-miR-144-ZEB1/EZH2 axis is critical for NSCLC progression, which indicates that hsa_circ_0020123 is a potential target for NSCLC treatment." 9 "The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells." - hsa_circ_ACAP2 circRNA-ACAP2 DOID:219 colon cancer colon cancer RT-qPCR up-regulated "The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells." 2 Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis. hsa_circ_0001953 hsa_circ_ZFY - DOID:399 tuberculosis active tuberculosis "RT-qPCR, microarray" up-regulated The present findings indicate that the circRNAs hsa_circ_0001953 and hsa_circ_0009024 may represent novel plasma biomarkers for active TB diagnosis. 1 Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis. hsa_circ_0009024 hsa_circ_TXLNG2P - DOID:399 tuberculosis active tuberculosis "RT-qPCR, microarray" up-regulated The present findings indicate that the circRNAs hsa_circ_0001953 and hsa_circ_0009024 may represent novel plasma biomarkers for active TB diagnosis. 1 Hsa_circ_0033155: A potential novel biomarker for non-small cell lung cancer. hsa_circ_0033155 hsa_circ_EML1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated hsa_circ_0033155 may serve as a prospective biomarker for detection and a promising therapeutic target for NSCLC. 1 Circular RNA hsa_circ_0000993 inhibits metastasis of gastric cancer cells. hsa_circ_0000993 hsa_circ_ATL2 - DOID:10534 stomach cancer gastric cancer RNA-seq down-regulated "In conclusion, hsa_circ_0000993 may inhibit metastasis of gastric cancer through sequestering miR-214-5p." 1 Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for rheumatoid arthritis. hsa_circ_0044235 hsa_circ_CDC27 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR down-regulated This study suggests that the hsa_circ_0044235 in peripheral blood may be a potential biomarker of patients with RA. 3 Upregulated circular RNA circ-102004 that promotes cell proliferation in prostate cancer. - - circ-102004 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated Circ-102004 is a potential oncogenic gene that regulates the development and progression of PCa. This study provides a scientific basis for targeting circ-102004 for either diagnosis or therapy. 1 "Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis." hsa_circ_0025039 hsa_circ_FOXM1 - DOID:1909 melanoma melanoma microarray up-regulated "Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis." 2 CircBA93 supports the survival of leukaemic cells by up-regulating c-ABL1 or BCR-ABL1 protein levels. - hsa_circ_BA9.3 - DOID:1240 leukemia leukemia RT-qPCR up-regulated CircBA9.3 supports the survival of leukaemic cells by up-regulating c-ABL1 or BCR-ABL1 protein levels. 1 CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer. - hsa_circ_KIAA1244 circ-KIAA1244 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "Results showed lower expression of circ-KIAA1244 in GC tissues, plasmas, and cells compare to normal controls." 1 Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer. - - F-circEA-2a DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "This work finds a novel oncogenic circRNA generated from EML4-ALK fusion gene, highlighting the pivotal role of circRNA in EML4-ALK-positive NSCLC development." 1 hsa_circ_0061140 Knockdown Reverses FOXM1-Mediated Cell Growth and Metastasis in Ovarian Cancer through miR-370 Sponge Activity. hsa_circ_0061140 hsa_circ_C20orf11 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated hsa_circ_0061140 appeared to function as a competing endogenous RNA of miR-370 that promoted cell growth and metastasis in ovarian cancer through regulation of the miR-370/FOXM1 pathway mediating EMT. 3 "The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4(+) T cells of systemic lupus erythematous." hsa_circ_0012919 hsa_circ_GNG12 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" down-regulated "Down-regulation of hsa_circ_0012919 (i) increased the expression of DNMT1 and reduced the expression of CD70, CD11a, (ii) reversed the DNA hypomethylation of CD11a and CD70 in CD4(+) T cells of SLE, but it could be reversed by down-regulation of DNMT1. Hsa_circ_0012919 regulated KLF13 and RANTES by miR-125a Conclusion: Hsa_circ_0012919 could be regarded as a biomarker for SLE and hsa_circ_0012919 was the competitive endogenous RNA (ceRNA) for miR-125a-3p." 1 Hsa_circ_0003998 promotes cell proliferation and invasion by targeting miR-326 in non-small cell lung cancer. hsa_circ_0003998 hsa_circ_ARFGEF2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Hsa_circ_0003998 promotes cell proliferation and invasion by targeting miR-326 in non-small cell lung cancer. 2 The circular RNA circ-ITCH suppresses ovarian carcinoma progression through targeting miR-145/RASA1 signaling. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated The circular RNA circ-ITCH suppresses ovarian carcinoma progression through targeting miR-145/RASA1 signaling. 4 Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532-3p / FOXO4 axis. - - hsa_circRNA_103809 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532-3p / FOXO4 axis. 2 CircSEMA4B targets miR-431 modulating IL-1beta-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway. - hsa_circ_SEMA4B - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated "CircSEMA4B serves as a miR-431 sponge to compete with SFRP1 or GSK-3beta for miR-431 binding, thus inhibiting IL-1beta-induced degenerative process in NPCs through Wnt signaling." 2 CircSEMA4B targets miR-431 modulating IL-1beta-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway. - hsa_circ_PARP12 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated "CircSEMA4B serves as a miR-431 sponge to compete with SFRP1 or GSK-3beta for miR-431 binding, thus inhibiting IL-2beta-induced degenerative process in NPCs through Wnt signaling." 1 CircSEMA4B targets miR-431 modulating IL-1beta-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway. - hsa_circ_ZNF652 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated "CircSEMA4B serves as a miR-431 sponge to compete with SFRP1 or GSK-3beta for miR-431 binding, thus inhibiting IL-3beta-induced degenerative process in NPCs through Wnt signaling." 1 CircSEMA4B targets miR-431 modulating IL-1beta-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway. - hsa_circ_ARL15 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated "CircSEMA4B serves as a miR-431 sponge to compete with SFRP1 or GSK-3beta for miR-431 binding, thus inhibiting IL-4beta-induced degenerative process in NPCs through Wnt signaling." 2 CircSEMA4B targets miR-431 modulating IL-1beta-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway. - hsa_circ_SPG21 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated "CircSEMA4B serves as a miR-431 sponge to compete with SFRP1 or GSK-3beta for miR-431 binding, thus inhibiting IL-5beta-induced degenerative process in NPCs through Wnt signaling." 1 CircSEMA4B targets miR-431 modulating IL-1beta-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway. - hsa_circ_GSPT1 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated "CircSEMA4B serves as a miR-431 sponge to compete with SFRP1 or GSK-3beta for miR-431 binding, thus inhibiting IL-6beta-induced degenerative process in NPCs through Wnt signaling." 1 Circ0043898 acts as a tumor inhibitor and performs regulatory effect on the inhibition of esophageal carcinoma. hsa_circ_0043898 hsa_circ_EZH1 circ0043898 DOID:1107 esophageal carcinoma esophageal carcinoma "RT-qPCR, RNA-seq" down-regulated Circ0043898 is presented as tumor inhibitor and could be a candidate biomarker in the therapeutic target and diagnosis of esophageal carcinoma. 1 Circular RNA hsa_circ_0052112 promotes cell migration and invasion by acting as sponge for miR-125a-5p in breast cancer. hsa_circ_0052112 hsa_circ_ZNF83 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circular RNA hsa_circ_0052112 promotes cell migration and invasion by acting as sponge for miR-125a-5p in breast cancer. 1 Differentially expressed circular RNAs in systemic lupus erythematosus and their clinical significance. - - hsa_circRNA_001308 DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated The results of qRT-PCR showed that the levels of hsa_circRNA_407176 and hsa_circRNA_001308 were decreased in both plasma and PBMCs of SLE when compared with healthy controls. 1 Differentially expressed circular RNAs in systemic lupus erythematosus and their clinical significance. - - hsa_circRNA_407176 DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated The results of qRT-PCR showed that the levels of hsa_circRNA_407176 and hsa_circRNA_001309 were decreased in both plasma and PBMCs of SLE when compared with healthy controls. 1 CircScd1 Promotes Fatty Liver Disease via the Janus Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway. - hsa_circ_Scd1 - DOID:80208 non-alcoholic fatty liver disease nonalcoholic fatty liver disease "RT-qPCR, microarray" down-regulated Aberrant expression of circScd1 affects the extent of hepatocellular lipidosis in NAFLD and promotes fatty liver disease via the JAK2/STAT5 pathway. 1 Circular Ribonucleic Acid Expression Profile in Mouse Cortex after Traumatic Brain Injury. - - circRNA_16895 DOID:81292 traumatic brain injury traumatic brain injury "RT-qPCR, RNA-seq" down-regulated Our results provide promising functions of circRNAs aberrantly expressed in TBI to explore molecular mechanisms and potential therapeutic targets for its therapy. 1 Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-beta-induced epithelial-mesenchymal transition and metastasis by controlling TIF1gamma in non-small cell lung cancer. hsa_circ_0008305 hsa_circ_PTK2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" down-regulated Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-beta-induced epithelial-mesenchymal transition and metastasis by controlling TIF1gamma in non-small cell lung cancer. 3 A novel circulating hsa_circ_0081001 act as a potential biomarker for diagnosis and prognosis of osteosarcoma. hsa_circ_0081001 hsa_circ_CYP51A1 - DOID:3347 osteosarcoma osteosarcoma RNA-seq up-regulated our study suggested that circulating hsa_circ_0081001 could serve as a potential biomarker and therapeutic target for OS patients. 3 Circular RNA 101368/miR-200a axis modulates the migration of hepatocellular carcinoma through HMGB1/RAGE signaling. - - circRNA-101368 DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray up-regulated we demonstrated a network of circRNAs-miRNA-mRNA in HCC and provided a novel mechanism of HCC cell migration regulation. 1 Profiling and bioinformatics analyses reveal differential expression of circular RNA in tongue cancer revealed by high-throughput sequencing. hsa_circ_0000231 hsa_circ_ARHGAP12 - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "The current study is the first to systematically characterize and annotate circRNA expression in TSCC, the majority were novel circRNAs. Some host genes of the DE circRNAs were involved in tumor signaling pathway and had complicated correlations with tumor-relevant miRNAs, indicating that circRNAs might be promoted development and progression of TSCC." 2 Profiling and bioinformatics analyses reveal differential expression of circular RNA in tongue cancer revealed by high-throughput sequencing. hsa_circ_0002162 hsa_circ_PTK2 - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "The current study is the first to systematically characterize and annotate circRNA expression in TSCC, the majority were novel circRNAs. Some host genes of the DE circRNAs were involved in tumor signaling pathway and had complicated correlations with tumor-relevant miRNAs, indicating that circRNAs might be promoted development and progression of TSCC." 2 Profiling and bioinformatics analyses reveal differential expression of circular RNA in tongue cancer revealed by high-throughput sequencing. hsa_circ_0002837 hsa_circ_TGFB1 - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "The current study is the first to systematically characterize and annotate circRNA expression in TSCC, the majority were novel circRNAs. Some host genes of the DE circRNAs were involved in tumor signaling pathway and had complicated correlations with tumor-relevant miRNAs, indicating that circRNAs might be promoted development and progression of TSCC." 1 Profiling and bioinformatics analyses reveal differential expression of circular RNA in tongue cancer revealed by high-throughput sequencing. hsa_circ_0007976 hsa_circ_HIF1A - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "The current study is the first to systematically characterize and annotate circRNA expression in TSCC, the majority were novel circRNAs. Some host genes of the DE circRNAs were involved in tumor signaling pathway and had complicated correlations with tumor-relevant miRNAs, indicating that circRNAs might be promoted development and progression of TSCC." 1 Profiling and bioinformatics analyses reveal differential expression of circular RNA in tongue cancer revealed by high-throughput sequencing. hsa_circ_0001742 hsa_circ_SMO - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "The current study is the first to systematically characterize and annotate circRNA expression in TSCC, the majority were novel circRNAs. Some host genes of the DE circRNAs were involved in tumor signaling pathway and had complicated correlations with tumor-relevant miRNAs, indicating that circRNAs might be promoted development and progression of TSCC." 4 Profiling and bioinformatics analyses reveal differential expression of circular RNA in tongue cancer revealed by high-throughput sequencing. hsa_circ_0005615 hsa_circ_NFATC3 - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "The current study is the first to systematically characterize and annotate circRNA expression in TSCC, the majority were novel circRNAs. Some host genes of the DE circRNAs were involved in tumor signaling pathway and had complicated correlations with tumor-relevant miRNAs, indicating that circRNAs might be promoted development and progression of TSCC." 1 The effect of Hsa_circ_0001451 in clear cell renal cell carcinoma cells and its relationship with clinicopathological features. hsa_circ_0001451 hsa_circ_FBXW7 - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR down-regulated our finding showed that Hsa_circ_0001451 might become a novel potential biomarker in the diagnosis of ccRCC and a potential novel target for the treatment of ccRCC. 2 Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis. - - hsa_circRNA_100906 DOID:0050156 idiopathic pulmonary fibrosis idiopathic pulmonary fibrosis "RT-qPCR, microarray" up-regulated "hsa_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls." 1 Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis. - - hsa_circRNA_102100 DOID:0050156 idiopathic pulmonary fibrosis idiopathic pulmonary fibrosis "RT-qPCR, microarray" up-regulated "hsa_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls." 1 Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis. - - hsa_circRNA_102348 DOID:0050156 idiopathic pulmonary fibrosis idiopathic pulmonary fibrosis "RT-qPCR, microarray" up-regulated "hsa_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls." 1 Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis. - - hsa_circRNA_101225 DOID:0050156 idiopathic pulmonary fibrosis idiopathic pulmonary fibrosis "RT-qPCR, microarray" down-regulated "hsa_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls." 1 Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis. - - hsa_circRNA_104780 DOID:0050156 idiopathic pulmonary fibrosis idiopathic pulmonary fibrosis "RT-qPCR, microarray" down-regulated "hsa_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls." 1 Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis. - - hsa_circRNA_101242 DOID:0050156 idiopathic pulmonary fibrosis idiopathic pulmonary fibrosis "RT-qPCR, microarray" down-regulated "hsa_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls." 1 Circular RNA profiling reveals circEXOC6B and circN4BP2L2 as novel prognostic biomarkers in epithelial ovarian cancer. - hsa_circ_EXOC6B - DOID:2152 ovary epithelial cancer epithelial ovarian cancer "RT-qPCR, RNA-seq" up-regulated "More importantly, we found that circEXOC6B and circN4BP2L2 may act as novel prognostic biomarkers in patients with EOC." 1 Circular RNA profiling reveals circEXOC6B and circN4BP2L2 as novel prognostic biomarkers in epithelial ovarian cancer. - hsa_circ_N4BP2L2 - DOID:2152 ovary epithelial cancer epithelial ovarian cancer "RT-qPCR, RNA-seq" up-regulated "More importantly, we found that circEXOC6B and circN4BP2L2 may act as novel prognostic biomarkers in patients with EOC." 2 Circular RNA Expression Profile and Analysis of Their Potential Function in Psoriasis. hsa_circ_0061012 hsa_circ_SLMO2-ATP5E - DOID:8893 psoriasis psoriasis "RT-qPCR, microarray" up-regulated "hsa_circ_0061012 was upregulated in psoriatic lesions compared with normal healthy skin tissues. The top five MREs of hsa_circ_0061012 were hsa-miR-7157-5p, hsa-miR-4769-3p, hsa-miR-6817-5p, hsa-miR-4310, and hsa-miR-6882-3p. " 2 Circular RNA Expression Profile in Laryngeal Squamous Cell Carcinoma Revealed by Microarray. hsa_circ_0044520 hsa_circ_COL1A1 - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "hsa_circ_0044520 and hsa_circ_0044529 play important regulatory roles by sponging hsa-miR-4726-5p and hsa-miR-4640-5p, thereby providing novel insights into the tumorigenesis of LSCC." 3 Circular RNA Expression Profile in Laryngeal Squamous Cell Carcinoma Revealed by Microarray. hsa_circ_0044529 hsa_circ_COL1A1 - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "hsa_circ_0044520 and hsa_circ_0044529 play important regulatory roles by sponging hsa-miR-4726-5p and hsa-miR-4640-5p, thereby providing novel insights into the tumorigenesis of LSCC." 3 Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis. - hsa_circ_BCRC-3 circular RNA BCRC-3 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "BCRC-3 functions as a tumor inhibitor to suppress BC cell proliferation through miR-182-5p/p27 axis, which would be a novel target for BC therapy." 1 Intrathecal circHIPK3 shRNA alleviates neuropathic pain in diabetic rats. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:9351 diabetes mellitus diabetes "RT-qPCR, microarray" up-regulated "circHIPK3 are highly abundant in serum from diabetes patients who suffered from neuropathic pain and in dorsal root ganglion from STZ-induced diabetes rats. Upregulation of circHIPK3 was positively associated with grade neuropathic pain in patients with type 2 diabetes. Silencing circHIPK3 alleviated neuropathic pain in diabetic rats, which was involved in neuroinflammation. Further mechanistic investigation demonstrated that circHIPK3 interacted with miR-124 and negatively regulated its expression. MiR-124 inhibitor can reverse circHIPK3 knockdown-mediated alleviation of neuropathic pain and inhibition of neuroinflammation in diabetic rats." 2 Intrathecal circHIPK3 shRNA alleviates neuropathic pain in diabetic rats. hsa_circ_0000284 rno_circ_HIPK3 - DOID:9351 diabetes mellitus diabetes "RT-qPCR, microarray" up-regulated "circHIPK3 are highly abundant in serum from diabetes patients who suffered from neuropathic pain and in dorsal root ganglion from STZ-induced diabetes rats. Upregulation of circHIPK3 was positively associated with grade neuropathic pain in patients with type 2 diabetes. Silencing circHIPK3 alleviated neuropathic pain in diabetic rats, which was involved in neuroinflammation. Further mechanistic investigation demonstrated that circHIPK3 interacted with miR-124 and negatively regulated its expression. MiR-124 inhibitor can reverse circHIPK4 knockdown-mediated alleviation of neuropathic pain and inhibition of neuroinflammation in diabetic rats." 1 "CircZNF609 promotes breast cancer cell growth, migration, and invasion by elevating p70S6K1 via sponging miR-145-5p." - hsa_circ_ZNF609 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "These data suggest that circZNF609 contributes to breast cancer progression, at least partly, by modulating the miR-145-5p/p70S6K1 axis, and it may be a potential therapeutic target for breast cancer." 2 Hsa_circ_101280 promotes hepatocellular carcinoma by regulating miR-375/JAK2. - - hsa_circ_101280 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "both the in vitro and in vivo studies revealed that hsa_circ_101280 largely facilitated the tumorigenesis of HCC, characterized by the promoted proliferation and suppressed apoptosis of HCC cells, by sponging miR-375 and upregulating JAK2." 1 CircRNA_001569 promotes cell proliferation through absorbing miR-145 in gastric cancer. - - circRNA_001569 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "the present study indicated that overexpressed circRNA_001569 promoted cell viability of gastric cancer through suppressing the expression of miR-145, which was mediated by NR4A2. The research will provide great theoretical basis for further clinical diagnosis and therapy." 1 PRMT5 Circular RNA Promotes Metastasis of Urothelial Carcinoma of the Bladder through Sponging miR-30c to Induce Epithelial-Mesenchymal Transition. - hsa_circ_PRMT5 circPRMT5 DOID:4006 bladder urothelial carcinoma urothelial carcinoma of the bladder microarray up-regulated "CircPRMT5 exerts critical roles in promoting UCB cells EMT and/or aggressiveness and is a prognostic biomarker of the disease, suggesting that circPRMT5 may serve as an exploitable therapeutic target for patients with UCB." 1 "circDiaph3 regulates rat vascular smooth muscle cell differentiation, proliferation, and migration." - hsa_circ_Diaph3 - DOID:178 vascular disease vascular injury microarray up-regulated circDiaph3 could be a molecular target to combat intimal hyperplasia. 1 Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer. - hsa_circ_UBXN7 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated The circUBXN7-miR-1247-3p-B4GALT3 regulatory network may provide a new perspective for gene-based treatment strategies for BC. 1 Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer progression through the miR-661/MTA1 pathway. hsa_circ_0001846 hsa_circ_UBAP2 circ-UBAP2 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer microarray up-regulated Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer progression through the miR-661/MTA1 pathway. 1 The competing endogenous circular RNA ADAMTS14 suppressed hepatocellular carcinoma progression through regulating microRNA-572/regulator of calcineurin 1. - hsa_circ_ADAMTS14 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated Our results demonstrated that circADAMTS14 might suppress HCC progression through regulating miR-572/ RCAN1 as the competing endogenous RNA. 1 "High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars." - - Circ_Chr17_50189167_50198002_- DOID:11430 endometriosis in scar of skin hypertrophic scar "RT-qPCR, RNA-seq" up-regulated "lncRNAs and circRNAs may act as ceRNAs, which are implicated in the pathophysiology and development of human HS, and lay a foundation for further insight into the novel regulatory mechanism of lncRNAs and circRNAs in hypertrophic scarring." 1 "High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars." - - Circ_Chr17_50189858_50195330_- DOID:11430 endometriosis in scar of skin hypertrophic scar "RT-qPCR, RNA-seq" up-regulated "lncRNAs and circRNAs may act as ceRNAs, which are implicated in the pathophysiology and development of human HS, and lay a foundation for further insight into the novel regulatory mechanism of lncRNAs and circRNAs in hypertrophic scarring." 1 "High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars." - - Circ_Chr17_50189167_50194626_- DOID:11430 endometriosis in scar of skin hypertrophic scar "RT-qPCR, RNA-seq" up-regulated "lncRNAs and circRNAs may act as ceRNAs, which are implicated in the pathophysiology and development of human HS, and lay a foundation for further insight into the novel regulatory mechanism of lncRNAs and circRNAs in hypertrophic scarring." 1 "High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars." - - Circ_Chr17_50190326_50194041_- DOID:11430 endometriosis in scar of skin hypertrophic scar "RT-qPCR, RNA-seq" up-regulated "lncRNAs and circRNAs may act as ceRNAs, which are implicated in the pathophysiology and development of human HS, and lay a foundation for further insight into the novel regulatory mechanism of lncRNAs and circRNAs in hypertrophic scarring." 1 "High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars." - - Circ_Chr2_72718102_72733118_- DOID:11430 endometriosis in scar of skin hypertrophic scar "RT-qPCR, RNA-seq" down-regulated "lncRNAs and circRNAs may act as ceRNAs, which are implicated in the pathophysiology and development of human HS, and lay a foundation for further insight into the novel regulatory mechanism of lncRNAs and circRNAs in hypertrophic scarring." 1 "High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars." - - Circ_Chr11_33286412_33287511_+ DOID:11430 endometriosis in scar of skin hypertrophic scar "RT-qPCR, RNA-seq" down-regulated "lncRNAs and circRNAs may act as ceRNAs, which are implicated in the pathophysiology and development of human HS, and lay a foundation for further insight into the novel regulatory mechanism of lncRNAs and circRNAs in hypertrophic scarring." 1 Analysis of differentially expressed circular RNAs for the identification of a coexpression RNA network and signature in colorectal cancer. hsa_circ_0000826 hsa_circ_ANKRD12 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated These findings indicate a set of differentially expressed circRNAs that may serve as a candidate diagnostic biomarker and a promising therapeutic target in CRC. 3 Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma. hsa_circ_0005320 hsa_circ_SEPT9 - DOID:0050929 mucosal melanoma metastatic oral mucosal melanoma microarray up-regulated "Among them, hsa_circ_0005320, hsa_circ_0067531, hsa_circ_0008042 were significantly upregulated in primary tumor and metastatic lymph nodes compared to paired adjacent normal tissues and non-metastatic lymph nodes, whereas the expression of hsa_circ_0000869 and hsa_circ_0000853 were downregulated relatively." 1 Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma. hsa_circ_0067531 hsa_circ_PIK3CB - DOID:0050929 mucosal melanoma metastatic oral mucosal melanoma microarray up-regulated "Among them, hsa_circ_0005320, hsa_circ_0067531, hsa_circ_0008042 were significantly upregulated in primary tumor and metastatic lymph nodes compared to paired adjacent normal tissues and non-metastatic lymph nodes, whereas the expression of hsa_circ_0000869 and hsa_circ_0000853 were downregulated relatively." 1 Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma. hsa_circ_0008042 hsa_circ_CPEB4 - DOID:0050929 mucosal melanoma metastatic oral mucosal melanoma microarray up-regulated "Among them, hsa_circ_0005320, hsa_circ_0067531, hsa_circ_0008042 were significantly upregulated in primary tumor and metastatic lymph nodes compared to paired adjacent normal tissues and non-metastatic lymph nodes, whereas the expression of hsa_circ_0000869 and hsa_circ_0000853 were downregulated relatively." 1 Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma. hsa_circ_0000869 hsa_circ_GNG7 - DOID:0050929 mucosal melanoma metastatic oral mucosal melanoma microarray down-regulated "Among them, hsa_circ_0005320, hsa_circ_0067531, hsa_circ_0008042 were significantly upregulated in primary tumor and metastatic lymph nodes compared to paired adjacent normal tissues and non-metastatic lymph nodes, whereas the expression of hsa_circ_0000869 and hsa_circ_0000853 were downregulated relatively." 1 Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma. hsa_circ_0000853 hsa_circ_MALT1 - DOID:0050929 mucosal melanoma metastatic oral mucosal melanoma microarray down-regulated "Among them, hsa_circ_0005320, hsa_circ_0067531, hsa_circ_0008042 were significantly upregulated in primary tumor and metastatic lymph nodes compared to paired adjacent normal tissues and non-metastatic lymph nodes, whereas the expression of hsa_circ_0000869 and hsa_circ_0000853 were downregulated relatively." 1 Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 (Kip1) axis. - hsa_circ_YAP1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Our findings demonstrate that circYAP1 functions as a tumor suppressor in GC cells by targeting the miR-367-5p/p27 Kip1 axis and may provide a prognostic indicator of survival in GC patients. 1 Circular RNA circ-NT5C2 acts as a potential novel biomarker for prognosis of osteosarcoma. - hsa_circ_NT5C2 circ-NT5C2 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circ-NT5C2 is significantly up-regulated in osteosarcoma tissues. Circ-NT5C2 may represent a new marker of prognosis in osteosarcoma. 2 Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. hsa_circ_0135889 hsa_circ_AGO2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated These results indicate that oncogenic circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. 1 Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. hsa_circ_0135889 hsa_circ_AGO2 - DOID:219 colon cancer colon cancer RT-qPCR up-regulated These results indicate that oncogenic circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. 1 Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. hsa_circ_0135889 hsa_circ_AGO2 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated These results indicate that oncogenic circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. 1 Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. hsa_circ_0135889 hsa_circ_AGO2 - DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated These results indicate that oncogenic circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. 2 Circ-U2AF1 promotes human glioma via derepressing neuro-oncological ventral antigen 2 by sponging hsa-miR-7-5p. - hsa_circ_U2AF1 circ-U2AF1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated We suggest that circ-U2AF1 can be a prognostic biomarker and the circ-U2AF1/hsa-miR-7-5p/NOVA2 regulatory pathway may be a novel therapeutic target for treating gliomas. 1 CircRNA has_circ_0078710 acts as the sponge of microRNA-31 involved in hepatocellular carcinoma progression. hsa_circ_0078710 hsa_circ_THBS2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "In vitro and in vivo functional studies showed that overexpression of has_circ_0078710 in HepG2, SMMC-7721 cell lines significantly promoted cell proliferation, migration, invasion and tumor growth by inducing the cell cycle progression. In summary, we identified Has_circ_0078710 as a potential HCC biomarker." 1 Overexpression of circ-0067934 is associated with increased cellular proliferation and the prognosis of non-small cell lung cancer. hsa_circ_0067934 hsa_circ_PRKCI circ-0067934 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ-0067934 was identified as an independent risk factor for OS time in patients with NSCLC, as assessed using univariate and multivariate Cox proportional hazards regression models." 3 Expression of circ_001569 is upregulated in osteosarcoma and promotes cell proliferation and cisplatin resistance by activating the Wnt/beta-catenin signaling pathway. - - circ_001569 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Expression of circ_001569 is upregulated in osteosarcoma and promotes cell proliferation and cisplatin resistance by activating the Wnt/beta-catenin signaling pathway. 1 Hsa_circ_0008309 May Be a Potential Biomarker for Oral Squamous Cell Carcinoma. hsa_circ_0008309 hsa_circ_CUL3 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "the results of the present study revealed that OSCC tissues have abundant circRNAs and, to the best of our knowledge, we firstly explore the regulatory role of the hsa_circ_0008309-miR-136-5P/hsa-miR-382-5P-ATXN1 network in OSCC. The results indicated that hsa_circ_0008309 may be a potential biomarker for OSCC." 1 "Circ-ITCH correlates with small tumor size, decreased FIGO stage and prolonged overall survival, and it inhibits cells proliferation while promotes cells apoptosis in epithelial ovarian cancer." - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:2152 ovary epithelial cancer epithelial ovarian cancer RT-qPCR down-regulated "Circ-ITCH correlates with small tumor size, decreased FIGO stage and prolonged OS, and it inhibits cells proliferation while promotes cells apoptosis in EOC." 1 The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway. - hsa_circ_ACR - DOID:1287 cardiovascular system disease cardiovascular disease RT-qPCR down-regulated Our findings reveal a novel role for the circRNA in regulating autophagy and ACR-Pink1-FAM65B axis as a regulator of autophagy in the heart will be potential therapeutic targets in treatment of cardiovascular diseases. 1 Circ-DLG1 promotes the proliferation of esophageal squamous cell carcinoma. hsa_circ_0007203 hsa_circ_DLG1 circ-DLG1 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated Our study indicated that upregulation of circ-DLG1 promoted esophageal cell proliferation ability and might serve as a novel biomarker for ESCC. 1 Circular RNA Expression in Oral Squamous Cell Carcinoma. - - circ_000334 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "the expression of circ_000334, circ_006740, and circ_006371 are significantly down-regulated in 42 pairs of samples, which means that these circRNA molecules might be implicated in oncogenesis and development of OSCCs." 1 Circular RNA Expression in Oral Squamous Cell Carcinoma. - - circ_006740 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "the expression of circ_000334, circ_006740, and circ_006371 are significantly down-regulated in 42 pairs of samples, which means that these circRNA molecules might be implicated in oncogenesis and development of OSCCs." 1 Circular RNA Expression in Oral Squamous Cell Carcinoma. - - circ_006371 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "the expression of circ_000334, circ_006740, and circ_006371 are significantly down-regulated in 42 pairs of samples, which means that these circRNA molecules might be implicated in oncogenesis and development of OSCCs." 1 Circular RNA HIPK3 exerts oncogenic properties through suppression of miR-124 in lung cancer. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated These observations indicate a possible novel therapeutic strategy involving circHIPK3-miR-124 pathway against lung cancer. 4 circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma. - - circ_104075 DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray up-regulated circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma. 1 Circ_0058063 regulates CDK6 to promote bladder cancer progression by sponging miR-145-5p. hsa_circ_0058063 hsa_circ_ATIC circ_0058063 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Circ_0058063 acted as a sponge of miR-145-5p to promote BC progression by regulating CDK6 expression, which provided some potential targets for BC treatment." 3 Overexpressed circ_0067934 acts as an oncogene to facilitate cervical cancer progression via the miR-545/EIF3C axis. hsa_circ_0067934 hsa_circ_PRKCI circ_0067934 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Our findings revealed that circ_0067934 promotes CC progression via miR-545/EIF3C axis. Our study may provide a new insight into the pathogenesis of CC. 1 CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer. hsa_circ_0008287 hsa_circ_GPATCH1 - DOID:8533 hypopharynx cancer hypopharyngeal cancer RNA-seq up-regulated "Of note, a ceRNA subnetwork was isolated, consisting of two circRNAs (hsa_circ_0008287 and hsa_circ_0005027) and one miRNA (hsa_miR_548c_3p), which significantly affect both ErbB and Hippo signaling pathways." 1 CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer. hsa_circ_0005027 hsa_circ_ARHGAP32 - DOID:8533 hypopharynx cancer hypopharyngeal cancer RNA-seq up-regulated "Of note, a ceRNA subnetwork was isolated, consisting of two circRNAs (hsa_circ_0008287 and hsa_circ_0005027) and one miRNA (hsa_miR_548c_3p), which significantly affect both ErbB and Hippo signaling pathways." 1 Hsa_circ_0136666 promotes the proliferation and invasion of colorectal cancer through miR-136/SH2B1 axis. hsa_circ_0136666 hsa_circ_PRKDC - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "Our data suggested that hsa_circ_0136666 could promote CRC cell progression via the miR-136/SH2B1 axis, elucidating a novel approach to improve the effectiveness of CRC treatment." 4 Upregulation of Circular RNA VPS13C-has-circ-001567 Promotes Ovarian Cancer Cell Proliferation and Invasion. - hsa_circ_VPS13C has-circ-001567 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated The VPS13C-has-circ-001567 plays a role in the development of OC and might be a prognostic marker and therapeutic target for OC. 1 "Upregulated circular RNA circ_0007534 indicates an unfavorable prognosis in pancreatic ductal adenocarcinoma and regulates cell proliferation, apoptosis, and invasion by sponging miR-625 and miR-892b." hsa_circ_0007534 hsa_circ_DDX42 circ_0007534 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated "Upregulated circular RNA circ_0007534 indicates an unfavorable prognosis in pancreatic ductal adenocarcinoma and regulates cell proliferation, apoptosis, and invasion by sponging miR-625 and miR-892b." 1 Silencing circular RNA UVRAG inhibits bladder cancer growth and metastasis by targeting the microRNA-223/fibroblast growth factor receptor 2 axis. - hsa_circ_UVRAG - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Silencing circular RNA UVRAG inhibited bladder cancer growth and metastasis by targeting the miR-223/FGFR2 axis, which may provide a potential biomarker and therapeutic target for the management of BLCA." 2 "Circular RNA hsa_circ_0074362 Promotes Glioma Cell Proliferation, Migration, and Invasion by Attenuating the Inhibition of miR-1236-3p on HOXB7 Expression." hsa_circ_0074362 hsa_circ_ARHGAP26 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated hsa_circ_0074362 played a crucial role in glioma progression by regulating the miR-1236-3p/HOXB7 pathway. 1 CircPAN3 mediates drug resistance in acute myeloid leukemia through the miR-153-5p/miR-183-5p-XIAP axis. - hsa_circ_PAN3 circPAN3 DOID:9119 acute myeloid leukemia acute myeloid leukemia microarray down-regulated Our findings provide evidence that circPAN3 can be a valuable indicator for predicting clinical efficacy of chemotherapy in AML patients and also can serve as a potential target for reversing drug resistance in AML. 2 Upregulation of circular RNA circ_0001721 predicts unfavorable prognosis in osteosarcoma and facilitates cell progression via sponging miR-569 and miR-599. hsa_circ_0001721 hsa_circ_CDK14 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "The present data reveal the participation of circ_0001721 in tumorigenesis of OS cells, and may indicate a novel therapeutic target." 5 Circular RNA Expression Profiling Identifies Prostate Cancer- Specific circRNAs in Prostate Cancer. hsa_circ_0057558 hsa_circ_SLC39A10 circ_0057558 DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" up-regulated Our results demonstrated that differentially expressed circRNAs (circ_0062019 and circ_0057558) and host gene SLC19A1 of circ_0062019 could be used as potential novel biomarkers for prostate cancer. 2 Circular RNA Expression Profiling Identifies Prostate Cancer- Specific circRNAs in Prostate Cancer. hsa_circ_0062019 hsa_circ_BCAS1 circ_0062019 DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" up-regulated Our results demonstrated that differentially expressed circRNAs (circ_0062019 and circ_0057558) and host gene SLC19A1 of circ_0062019 could be used as potential novel biomarkers for prostate cancer. 3 Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes. hsa_circ_0029696 hsa_circ_SKA3 circ-SKA3 DOID:0050902 medulloblastoma medulloblastoma RT-qPCR up-regulated circ-SKA3 and circ-DTL were crucial in the tumorigenesis and development of MB and might be considered as novel and potential biomarkers for the diagnosis and new targets for the intervention of MB. 4 Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes. hsa_circ_0000179 hsa_circ_DTL circ-DTL DOID:0050902 medulloblastoma medulloblastoma RT-qPCR up-regulated circ-SKA3 and circ-DTL were crucial in the tumorigenesis and development of MB and might be considered as novel and potential biomarkers for the diagnosis and new targets for the intervention of MB. 1 Circular RNA hsa_circ_0000523 regulates the proliferation and apoptosis of colorectal cancer cells as miRNA sponge. hsa_circ_0000523 hsa_circ_METTL3 circ_006229 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "The results suggested that the expression of hsa_circ_0000523 correlated to the tumorigenesis of colorectal cancer cells. In addition, as a sponge of miR-31, the low level of hsa_circ_0000523 led to activation of Wnt/beta-catenin signaling pathway, inducing the subsequent progress of colorectal cancer." 4 circCTIC1 promotes the self-renewal of colon TICs through BPTF-dependent c-Myc expression. - hsa_circ_CTIC1 - DOID:219 colon cancer colon cancer RT-qPCR up-regulated CircCTIC1 drove the self-renewal of colon TICs through bromodomain PHD finger transcription factor (BPTF)-mediated c-Myc expression. 1 Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity. hsa_circ_0000285 hsa_circ_HIPK3 circRNA_0000285 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated The present data indicated that circRNA_0000285 may be a novel biomarker for NPC and is involved in NPC radiosensitivity. 3 Circ_0027599/PHDLA1 suppresses gastric cancer progression by sponging miR-101-3p1. hsa_circ_0027599 hsa_circ_PHLDA1 circ_0027599 DOID:10534 stomach cancer gastric cancer microarray down-regulated "PHLDA1 was regulated by circ_0027599/miR-101, which suppressed gastric cancer survival and metastasis in gastric cancer." 2 Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway. - - ciRS-133 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Exosome-delivered circRNAs are involved in WAT browning and play a key role in cancer-associated cachexia. 1 CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. - mmu_circ_DYM - DOID:1470 major depressive disorder major depressive disorder RT-qPCR down-regulated "the involvement of circDYM and its coupling mechanism in depression, providing translational evidence that circDYM may be a novel therapeutic target for depression." 1 CircNUP214 sponges miR-145 to promote the expression of ZEB2 in thyroid cancer cells. hsa_circ_0089153 hsa_circ_NUP214 circNUP214 DOID:1781 thyroid gland cancer thyroid cancer microarray up-regulated "circNUP214 may play an oncogenic role in PTC by acting as a sponge for miR-145, leading to upregulation of ZEB2." 1 Profiling and bioinformatics analyses of differential circular RNA expression in prostate cancer cells. - hsa_circ_SLC7A6 - DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated "Altogether 9545 circRNAs were identified and hundreds of differentially expressed circRNAs were recognized. CircRNA_miRNA networks analysis showed that many circRNAs, including circSLC7A6, circGUCY1A2 and circZFP57 could cross-talk with tumor-related miRNAs such as miR-21, miR-143 and miR-200 family." 1 Profiling and bioinformatics analyses of differential circular RNA expression in prostate cancer cells. - hsa_circ_GUCY1A2 - DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated "Altogether 9545 circRNAs were identified and hundreds of differentially expressed circRNAs were recognized. CircRNA_miRNA networks analysis showed that many circRNAs, including circSLC7A6, circGUCY1A2 and circZFP57 could cross-talk with tumor-related miRNAs such as miR-21, miR-143 and miR-200 family." 1 Profiling and bioinformatics analyses of differential circular RNA expression in prostate cancer cells. - hsa_circ_ZFP57 - DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated "Altogether 9545 circRNAs were identified and hundreds of differentially expressed circRNAs were recognized. CircRNA_miRNA networks analysis showed that many circRNAs, including circSLC7A6, circGUCY1A2 and circZFP57 could cross-talk with tumor-related miRNAs such as miR-21, miR-143 and miR-200 family." 1 CircABCB10 promotes nonsmall cell lung cancer cell proliferation and migration by regulating the miR-1252/FOXR2 axis. - hsa_circ_ABCB10 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "The circABCB10 acted as a tumor promoter through a novel miR-1252/FOXR2 axis, providing potential biomarkers and therapeutic targets for the management of NSCLC." 4 CircRNA circPDSS1 promotes the gastric cancer progression by sponging miR-186-5p and modulating NEK2. - hsa_circ_PDSS1 circPDSS1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Thus, circPDSS1 acts as a tumor promoter by regulating miR-186-5p and NEK2, which could be a potential biomarker and therapeutic target for the management of GC." 2 Identification and integrated analysis of key differentially expressed circular RNAs in ER-positive subtype breast cancer. hsa_circ_0087378 hsa_circ_NTRK2 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated This study revealed the general expression characteristics of specific DECs in ER-positive BC and hsa_circ_0087378 might be a promising candidate target. 1 "A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus." - hsa_circ_FAT1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated The circFAT1(e2) may play a role as a tumor suppressor in GC cells by regulating the miR-548g/RUNX1 axis in the cytoplasm and targeting YBX1 in the nucleus. 1 CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of beta-catenin pathway. - - circRNA_102171 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated CircRNA_102171 overexpression promotes PTC progression through activating Wnt/beta-catenin pathway in a CTNNBIP1-dependent way. 1 Circular RNA-100290 promotes cell proliferation and inhibits apoptosis in acute myeloid leukemia cells via sponging miR-203. - - circular RNA-100290 DOID:9119 acute myeloid leukemia acute myeloid leukemia microarray up-regulated the present study identifies the crucial regulation of hsa_circ_100290 in AML cell proliferation and apoptosis via targeting the miR-203/Rab10 axis. 1 Contribution of dysregulated circRNA_100876 to proliferation and metastasis of esophageal squamous cell carcinoma. - - circRNA_100876 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "CircRNA_100876 expression was upregulated (P<0.05) and was negatively correlated with survival outcome (P<0.05) in ESCC. Inhibition of proliferation, migration, invasion, and epithelial_mesenchymal transition progression was confirmed after circRNA_100876 depletion." 1 CircRNA CDR1as/miR-7 signals promote tumor growth of osteosarcoma with a potential therapeutic and diagnostic value. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3347 osteosarcoma osteosarcoma microarray up-regulated "Inhibition of CDR1as in OS cell lines U2OS and MG63 with high CDR1as levels, leading to de-repressed miR-7 levels, impaired cell vitality and increased apoptosis and G1/S arrest in parallel with reduced ability of cell migration." 1 "circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma." - - hsa_circ_00156 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma." 1 "circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma." - - has_circ_000224 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma." 1 "circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma." - - hsa_circ_000520 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma." 1 FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer. - hsa_circ_FECR1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "This study identifies_LI1_xonic circular RNAs as a new oncogenic driver that promotes tumor metastasis through the miR584-ROCK1 pathway. Importantly, serum exosomal FECR1 may serve as a promising biomarker to track disease progression of SCLC." 1 Circular RNA CCDC66 targets DCX to regulate cell proliferation and migration by sponging miR-488-3p in Hirschsprung disease. - hsa_circ_CCDC66 cir-CCDC66 DOID:10487 Hirschsprung disease hirschsprung disease "RT-qPCR, RNA-seq" down-regulated This is the first report revealing that cir-CCDC66 modulates DCX expression through sponging miR-488-3p and thus participates in the onset of HSCR. 1 Circular RNA circRHOT1 is upregulated and promotes cell proliferation and invasion in pancreatic cancer. - hsa_circ_RHOT1 circRHOT1 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated This study demonstrated that circRHOT1 may serve as an oncogenic circRNA that promotes tumor progression. 1 Circular RNA Hsa_Circ_0091579 Serves as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma. hsa_circ_0091579 hsa_circ_GPC3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated Hsa_circ_0091579 may play a critical role in HCC progression and serve as a potential biomarker for the prognosis of patients with HCC. 6 The pro-metastasis effect of circANKS1B in breast cancer. hsa_circ_0007294 hsa_circ_ANKS1B - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated "circANKS1B abundantly sponged miR-148a-3p and miR-152-3p to increase the expression of transcription factor USF1, which could transcriptionally up-regulate TGF-beta1 expression, resulting in activating TGF-beta1/Smad signaling to promote EMT. " 1 Discovery of Kaposi sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA. hsa_circ_0001400 hsa_circ_RELL1 - DOID:8632 Kaposi sarcoma kaposi sarcoma RT-qPCR up-regulated "Ectopic expression of hsa_circ_0001400, a circRNA induced by infection, suppressed expression of key viral latent gene LANA and lytic gene RTA in KSHV de novo infections." 1 The profile analysis of circular RNAs in human placenta of preeclampsia. hsa_circ_0088227 hsa_circ_PAPPA - DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "our study displayed a preliminary landscape of circRNA differential expression in PE. These circRNAs may be involved in the changes of trophoblast function of PE placenta, especially circRNA_3286." 2 The profile analysis of circular RNAs in human placenta of preeclampsia. - hsa_circ_ACSS1 circRNA_5593 DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "our study displayed a preliminary landscape of circRNA differential expression in PE. These circRNAs may be involved in the changes of trophoblast function of PE placenta, especially circRNA_3287." 1 The profile analysis of circular RNAs in human placenta of preeclampsia. - hsa_circ_SHANK2 circRNA_3800 DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "our study displayed a preliminary landscape of circRNA differential expression in PE. These circRNAs may be involved in the changes of trophoblast function of PE placenta, especially circRNA_3288." 1 Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis. - hsa_circ_FNDC3B - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis. 2 Hsa_circ_0000467 promotes cancer progression and serves as a diagnostic and prognostic biomarker for gastric cancer. hsa_circ_0000467 hsa_circ_SKA3 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Hsa_circ_0000467 can act as a novel noninvasive biomarker for the diagnosis and prognosis of GC and may be a potential therapeutic target for GC. 3 Circular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis. - hsa_circ_LARP4 circular RNA_LARP4 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated These results indicated that circLARP4 expression was lower and highlighted that circLARP4 was identified as a potential biomarker of ovarian cancer prognosis. 2 CircZFR promotes hepatocellular carcinoma progression through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/beta-catenin pathway. - hsa_circ_ZFR - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated Our findings indicated that circZFR may exert carcinogenic role in HCC through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/beta-catenin pathway. 4 CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression. - hsa_circ_SLC3A2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated CircSLC3A2 acts as an oncogenic factor in HCC by sponging miR-490-3p and regulating PPM1F expression. 1 EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis. - hsa_circ_MMP9 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, microarray" up-regulated "Our findings indicate that eIF4A3-induced circMMP9 is an important underlying mechanism in GBM cell proliferation, invasion and metastasis through modulation of the miR-124 signaling pathway, which could provide pivotal potential therapeutic targets for the treatment of GBM." 1 CircRNA has_circ_0006427 suppresses the progression of lung adenocarcinoma by regulating miR-6783-3p/DKK1 axis and inactivating Wnt/beta-catenin signaling pathway. hsa_circ_0006427 hsa_circ_BCAR3 - DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" down-regulated Our study revealed that circ_0006427 suppressed lung adenocarcinoma progression through regulating miR-6783-3p/DKK1 axis. 1 "Screening and bioinformatics analysis of mRNA, long non-coding RNA and circular RNA expression profiles in mucoepidermoid carcinoma of salivary gland." hsa_circ_0012342 hsa_circ_MKNK1 - DOID:4531 mucoepidermoid carcinoma mucoepidermoid carcinoma microarray up-regulated NONHSAT154433.1 and hsa_circ_0012342 might be served as potential prognostic biomarkers and therapeutic target of MEC. 1 CircRNA ZNF609 functions as a competitive endogenous RNA to regulate FOXP4 expression by sponging miR-138-5p in renal carcinoma. - hsa_circ_ZNF609 circ-ZNF609 DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated Our current study reveals the role of the circ-ZNF609/miR-138-5p/FOXP4 regulatory network in renal carcinoma and provides a new perspective for the pathogenesis of renal carcinoma. 1 Thymosin-beta4 Mediates Hepatic Stellate Cell Activation by Interfering with CircRNA-0067835/miR-155/FoxO3 Signaling Pathway. hsa_circ_0067835 hsa_circ_IFT80 circRNA-0067835 DOID:409 liver disease liver fibrosis microarray up-regulated "Our experiments showed that circRNA-0067835 regulated liver fibrosis progression by acting as a sponge of miR-155 to promote FOXO3a expression, indicating that circRNA-0067835 may serve as a potential therapeutic target for patients with liver fibrosis." 1 CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance. hsa_circ_0109291 hsa_circ_ZNF714 circRNA_0109291 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated These findings indicated that hsa_circ_0109291 correlated with the progression of OSCC and might be a new therapeutic target for the treatment of OSCC. 2 Characterization of circRNA_associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation. - - hsa_circRNA002085 DOID:0060224 atrial fibrillation atrial fibrillation "RT-qPCR, RNA-seq" up-regulated "This study reveals a potential perspective from which to investigate circRNAs in circRNA_associated ceRNA networks (hsa_circRNA002085, hsa_circRNA001321) in NPAF, and provides a potential biomarker for AF." 1 Characterization of circRNA_associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation. - - hsa_circRNA001321 DOID:0060224 atrial fibrillation atrial fibrillation RNA-seq up-regulated "This study reveals a potential perspective from which to investigate circRNAs in circRNA_associated ceRNA networks (hsa_circRNA002085, hsa_circRNA001321) in NPAF, and provides a potential biomarker for AF." 1 Comprehensive Circular RNA Profiling Reveals the Regulatory Role of the CircRNA-0067835/miR-155 Pathway in Temporal Lobe Epilepsy. hsa_circ_0067835 hsa_circ_IFT80 circRNA-0067835 DOID:3328 temporal lobe epilepsy temporal lobe epilepsy "RT-qPCR, microarray" down-regulated "circRNA-0067835 regulated refractory epilepsy progression by acting as a sponge of miR-155 to promote FOXO3a expression, indicating that circRNA-0067835 may serve as a potential therapeutic target for patients with TLE." 1 CircPCNXL2 sponges miR-153 to promote the proliferation and invasion of renal cancer cells through upregulating ZEB2. - hsa_circ_PCNXL2 circPCNXL2 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma microarray up-regulated "we demonstrated that circPCNXL2 could regulate RCC cells proliferation and invasion by miR-153/ZEB2 axis, suggesting circPCNXL2 might serve as a potential therapeutic target for ccRCC treatment." 1 circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide. - hsa_circ_Gprc5a - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated we identified that circGprc5a was upregulated in most of bladder patients and played essential roles in CSC self-renewal in all six samples identified. 1 Increased Expression of Circular RNA circ_0005230 Indicates Dismal Prognosis in Breast Cancer and Regulates Cell Proliferation and Invasion via miR-618/ CBX8 Signal Pathway. hsa_circ_0005230 hsa_circ_DNM3OS circ_0005230 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circ_0005230/miR-618/CBX8 axis might play a key role in BC tumorigenesis and development. 1 Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression. hsa_circ_0076248 hsa_circ_ZFAND3 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Our study sheds light on the regulatory mechanism of hsa_circ_0076248 in glioma growth and invasion via sponging miR-181a, which downregulates the SIRT1 expression and also suggests that hsa_circ_0076248, miR-181a, and SIRT1 may serve as potential therapeutic targets for glioma." 1 Circ_0078767 suppresses non-small-cell lung cancer by protecting RASSF1A expression via sponging miR-330-3p. - - circ_0078767 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "Circ_0078767 could suppress NSCLC progression by inhibiting miR-330-3p, which thereby increased RASSF1 levels." 1 CircVRK1 regulates tumor progression and radioresistance in esophageal squamous cell carcinoma by regulating miR-624-3p/PTEN/PI3K/AKT signaling pathway. - hsa_circ_VRK1 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR down-regulated "The circVRK1 suppressed ESCC progression by regulating miR-624-3p/PTEN axis and PI3K/AKT signaling pathway, suggesting the potential therapeutic value of circVRK1 for ESCC." 1 Downregulation of hsa_circ_0000285 serves as a prognostic biomarker for bladder cancer and is involved in cisplatin resistance. hsa_circ_0000285 hsa_circ_HIPK3 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated Our study indicates hsa_circ_0000285 may be a novel biomarker for bladder cancer because of its involvement in bladder cancer chemo-sensitivity. 4 Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/beta-catenin pathway. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR down-regulated Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/beta-catenin pathway. 1 "Circular RNA hsa_circ_0004015 regulates the proliferation, invasion, and TKI drug resistance of non-small cell lung cancer by miR-1183/PDPK1 signaling pathway." hsa_circ_0004015 hsa_circ_CDK14 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "oncogenic effects of hsa_circ_0004015 was attributed to the regulation of miR-1183/PDPK1 axis. In conclusion, circ_0016760/miR-1183/PDPK1 signaling pathway might play vital roles in the tumorigenesis of NSCLC." 2 Circ-SFMBT2 promotes the proliferation of gastric cancer cells through sponging miR-182-5p to enhance CREB1 expression. - hsa_circ_SFMBT2 circ-SFMBT2 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our study reveals that circ-SFMBT2 participates in progression of gastric cancer by competitively sharing miR-182-5p with CREB1, providing a novel target to improve the treatment of gastric cancer." 4 CircFAT1 sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells. - hsa_circ_FAT1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circFAT1 contains a binding site for the microRNA-375 (miR-375) and can abundantly sponge miR-375 to upregulate the expression of Yes-associated protein 1. 2 Circ-TTC17 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma. - hsa_circ_TTC17 circ-TTC17 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "The results of this study demonstrate that upregulated circ-TTC17 plays a key role in promoting proliferation and migration of ESCC cells and has potential to become a novel biomarker for diagnosis, treatment, and prognosis of ESCC in the future." 1 Has_circ_0055625 from circRNA profile increases colon cancer cell growth by sponging miR-106b-5p. hsa_circ_0055625 hsa_circ_DUSP2 - DOID:219 colon cancer colon cancer microarray up-regulated "The circ_0055625/miR-106b/ITGB8 played a role in promoting tumor growth and metastasis, which suggested that circ_0055625 was a potential biomarker of colon cancer." 2 hsa_circRNA_0006528 as a competing endogenous RNA promotes human breast cancer progression by sponging miR-7-5p and activating the MAPK/ERK signaling pathway. hsa_circ_0006528 hsa_circ_PRELID2 hsa_circRNA_0006528 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated This study provides the first evidence of the circ_0006528/miR-7-5p/Raf1/MEK/ERK regulatory network in the development of breast cancer and suggests that circ_0006528 is a potential therapeutic target and prognostic predictor for breast cancer. 4 circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma. - hsa_circ_LARP4 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "The role of circLARP4/miR-761/RUNX3/p53/p21 signaling in HCC progression, providing a potential survival predictor and therapeutic candidate for HCC." 1 Circlular RNA BARD1 (Hsa_circ_0001098) overexpression in breast cancer cells with TCDD treatment could promote cell apoptosis via miR-3942/BARD1 axis. hsa_circ_0001098 hsa_circ_BARD1 circlular RNA BARD1 DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated TCDD induced circ_0001098 overexpression and then suppressed breast cancer tumorigenesis via miR-3942-3p/BARD1 axis. 1 Identification of Differentially Expressed Profiles of Alzheimer Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer Disease Mouse Model. - - mmu_circRNA_013636 DOID:10652 Alzheimer disease Alzheimer disease microarray up-regulated Panax notoginseng saponins (PNS) could significantly prohibit the pathological progress of AD.The present study shows that PNS may exhibit an ability to modulate the expression of AD-associated circRNAs. therapeutic effects of PNS on AD may be through modulating the expression of AD associated circRNAs and suggests that PNS is a potential circRNA-targeted agent against AD. 1 Identification of Differentially Expressed Profiles of Alzheimer Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer Disease Mouse Model. - - mmu_circRNA_012180 DOID:10652 Alzheimer disease Alzheimer disease microarray up-regulated Panax notoginseng saponins (PNS) could significantly prohibit the pathological progress of AD.The present study shows that PNS may exhibit an ability to modulate the expression of AD-associated circRNAs. therapeutic effects of PNS on AD may be through modulating the expression of AD associated circRNAs and suggests that PNS is a potential circRNA-targeted agent against AD. 2 Upregulation of circular RNA circ_0000502 predicts unfavorable prognosis in osteosarcoma and facilitates cell progression via sponging miR-1238. hsa_circ_0000502 hsa_circ_None circ_0000502 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ_0000502 was identified upregulated in both OS tissue specimens and cells. In addition, its expression predicts clinical severity and unfavorable prognosis.For mechanism exploration, circ_0000502 could directly sponge microRNA (miR)-1238." 1 CircPUM1 promotes the malignant behavior of lung adenocarcinoma by regulating miR-326. - hsa_circ_PUM1 circPUM1 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated This present study revealed that circPUM1 functions as an oncogene to promote the tumorigenesis of lung adenocarcinoma through circPUM1/miR-326/Cyclin D1 and Bcl-2 axis. 2 Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway. - hsa_circ_AMOTL1L - DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" down-regulated These findings have linked p53/RBM25-mediated circAMOTL1L-miR-193a-5p-Pcdha regulatory axis to EMT in metastatic progression of PCa. 1 Circular RNA profiling identifies circADAMTS13 as a miR-484 sponge which suppresses cell proliferation in hepatocellular carcinoma. - hsa_circ_ADAMTS13 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated The circADAMTS13 can serve as a tumor suppressor during HCC progression via the functional pathway of sponging miR-484. 1 circZMYM2 Competed Endogenously with miR-335-5p to Regulate JMJD2C in Pancreatic Cancer. hsa_circ_0099999 hsa_circ_ZMYM2 - DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated Our study demonstrated that circZMYM2 promoted PC progression. CircZMYM2 had a sponge effect on miR-335-5p and modulated the downstream oncogene JMJD2C. 2 Circular RNA circPVT1 Promotes Proliferation and Invasion Through Sponging miR-125b and Activating E2F2 Signaling in Non-Small Cell Lung Cancer. - hsa_circ_PVT1 circPVT1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circPVT1 promotes NSCLC cell growth and invasion, and may serve as a promising therapeutic target for NSCLC patients. Therefore, silence of circPVT1 could be a future direction to develop a novel treatment strategy." 2 A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1. - hsa_circ_FECR1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "FECR1 circular RNA acts as an upstream regulator to control breast cancer tumor growth by coordinating the regulation of DNA methylating and demethylating enzymes. Thus, FLI1 drives tumor metastasis not only through the canonical oncoprotein pathway, but also by using epigenetic mechanisms mediated by its exonic circular RNA." 1 Circular RNA EIF6 (Hsa_circ_0060060) sponges miR-144-3p to promote the cisplatin-resistance of human thyroid carcinoma cells by autophagy regulation. hsa_circ_0060060 hsa_circ_EIF6 - DOID:1781 thyroid gland cancer thyroid cancer "RT-qPCR, RNA-seq" up-regulated "circEIF6 promoted autophagy by regulating miR-144-3p/TGF-alpha axis, enhancing the cisplatin-resistance in PTC and ATC cells. CircEIF6 promoted tumor growth by regulating miR-144-3p/TGF-alpha and circEIF6 knock-down enhanced cisplatin sensitivity in vivo." 1 A two_circRNA signature predicts tumour recurrence in clinical non_functioning pituitary adenoma. hsa_circ_0000066 hsa_circ_RNF220 - DOID:3829 pituitary adenoma pituitary adenoma microarray up-regulated The present study is the first to suggest a circRNA signature with a clinical application value for predicting recurrence/progression in patients with NFPA. 1 A two_circRNA signature predicts tumour recurrence in clinical non_functioning pituitary adenoma. hsa_circ_0069707 hsa_circ_FRYL - DOID:3829 pituitary adenoma pituitary adenoma microarray up-regulated The present study is the first to suggest a circRNA signature with a clinical application value for predicting recurrence/progression in patients with NFPA. 1 Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7. - hsa_circ_DB circ-DB DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated exosome circRNAs secreted from adipocytes promote tumor growth and reduce DNA damage by suppressing miR-34a and activating the USP7/Cyclin A2 signaling pathway. 1 Overexpressed circ_0029426 in glioblastoma forecasts unfavorable prognosis and promotes cell progression by sponging miR-197. hsa_circ_0029426 hsa_circ_RAN circ_0029426 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, microarray" up-regulated Overexpressed circ_0029426 in glioblastoma forecasts unfavorable prognosis and promotes cell progression by sponging miR-197. 1 Hsa_circRNA_33287 promotes the osteogenic differentiation of maxillary sinus membrane stem cells via miR-214-3p/Runx3. - - circRNA_33287 DOID:0080001 bone disease osteogenic differentiation "RT-qPCR, microarray" up-regulated The novel pathway circRNA_33287/miR-214-3p/Runx3 was found to play a role in regulating the osteoblastic differentiation of MSMSCs in the posterior maxilla. 1 Circular RNA circMTO1 suppresses bladder cancer metastasis by sponging miR-221 and inhibiting epithelial-to-mesenchymal transition. - hsa_circ_MTO1 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated Our findings provide comprehensive evidences that circMTO1 is a prognostic biomarker in bladder cancer and suggest that circMTO1 may function as a novel therapeutic target in human bladder cancer. 1 Circular RNA circ_0034642 elevates BATF3 expression and promotes cell proliferation and invasion through miR-1205 in glioma. hsa_circ_0034642 hsa_circ_VPS18 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated The circ_0034642/miR-1205/BATF3 pathway may play an important role in glioma. 1 "Elevated expression of circular RNA circ_0008450 predicts dismal prognosis in hepatocellular carcinoma and regulates cell proliferation, apoptosis, and invasion via sponging miR-548p." hsa_circ_0008450 hsa_circ_CMTM3 circ_0008450 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated The oncogenic role of circ_0008450 was partially attributed to its suppression on miR-548p. 3 Circular RNA ITCH suppresses proliferation and promotes apoptosis in human epithelial ovarian cancer cells by sponging miR-10a-alpha. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated Circ-ITCH suppresses cells proliferation and promotes cells apoptosis via sponging miR-10a in EOC cells. 4 CircMTO1 inhibits cell proliferation and invasion by regulating Wnt/beta-catenin signaling pathway in colorectal cancer. - hsa_circ_MTO1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "We showed that circMTO1 could act as a tumor suppressor affecting the growth and invasion of CRC cells via regulating Wnt/beta-catenin signaling pathway, providing a novel potential biomarker and therapeutic target for CRC treatment." 1 Circ_0009910 regulates growth and metastasis and is associated with poor prognosis in gastric cancer. hsa_circ_0009910 hsa_circ_MFN2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Altogether, we demonstrate that circ_0009910 acts as a prognostic biomarker and promote cell proliferation, migration, invasion and EMT in GC, indicating that circ_0009910 may be a novel potential biomarker and therapeutic target of GC." 5 Circular RNA regulatory network reveals cell-cell crosstalk in acute myeloid leukemia extramedullary infiltration. hsa_circ_0004520 hsa_circ_VAV2 - DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, microarray" up-regulated Hsa_circRNA_0004520 was chosen for our interest on its target genes: PLXNB2 and VEGFA. Te expression of hsa_circRNA_0004520 was upregulated by 4.38-fold. 1 Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion. hsa_circ_0067705 hsa_circ_TM4SF1 - DOID:106 pleural tuberculosis malignant pleural effusion "RT-qPCR, microarray" up-regulated "Among the top 5 up-regulated circRNAs (hsa_circ_0067705, hsa_circ_0025542, hsa_circ_0072793, hsa_circ_0084927, and hsa_circ_0085386), four were verified significantly up-regulated in LA-MPE by qRT-PCR and hsa_circ_0085386 had an increasing trend. " 1 Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion. hsa_circ_0025542 hsa_circ_MGST1 - DOID:106 pleural tuberculosis malignant pleural effusion "RT-qPCR, microarray" up-regulated "Among the top 5 up-regulated circRNAs (hsa_circ_0067705, hsa_circ_0025542, hsa_circ_0072793, hsa_circ_0084927, and hsa_circ_0085386), four were verified significantly up-regulated in LA-MPE by qRT-PCR and hsa_circ_0085386 had an increasing trend. " 1 Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion. hsa_circ_0072793 hsa_circ_OCLN - DOID:106 pleural tuberculosis malignant pleural effusion "RT-qPCR, microarray" up-regulated "Among the top 5 up-regulated circRNAs (hsa_circ_0067705, hsa_circ_0025542, hsa_circ_0072793, hsa_circ_0084927, and hsa_circ_0085386), four were verified significantly up-regulated in LA-MPE by qRT-PCR and hsa_circ_0085386 had an increasing trend. " 1 Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion. hsa_circ_0084927 hsa_circ_ESRP1 - DOID:106 pleural tuberculosis malignant pleural effusion "RT-qPCR, microarray" up-regulated "Among the top 5 up-regulated circRNAs (hsa_circ_0067705, hsa_circ_0025542, hsa_circ_0072793, hsa_circ_0084927, and hsa_circ_0085386), four were verified significantly up-regulated in LA-MPE by qRT-PCR and hsa_circ_0085386 had an increasing trend. " 1 Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion. hsa_circ_0085386 hsa_circ_MAL2 - DOID:106 pleural tuberculosis malignant pleural effusion microarray up-regulated "Among the top 5 up-regulated circRNAs (hsa_circ_0067705, hsa_circ_0025542, hsa_circ_0072793, hsa_circ_0084927, and hsa_circ_0085386), four were verified significantly up-regulated in LA-MPE by qRT-PCR and hsa_circ_0085386 had an increasing trend. " 1 Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1. hsa_circ_0123778 hsa_circ_CTNNB1 circ-CTNNB1 DOID:162 cancer cancer RT-qPCR up-regulated "Circ-CTNNB1 was predominantly expressed in the nucleus, upregulated in cancer tissues and cell lines, and associated with unfavorable outcomes in patients with cancer." 1 Signature of circular RNAs in peripheral blood mononuclear cells from patients with active tuberculosis. - - hsa_circRNA_059914 DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" down-regulated "hsa_circRNA_103017, hsa_circRNA_059914 and hsa_circRNA_101128 were enhanced, while hsa_circRNA_062400 was reduced in the active TB patient group (n = 31) vs healthy patient group (n = 30)." 1 Signature of circular RNAs in peripheral blood mononuclear cells from patients with active tuberculosis. - - hsa_circRNA_103017 DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" down-regulated "hsa_circRNA_103017, hsa_circRNA_059914 and hsa_circRNA_101128 were enhanced, while hsa_circRNA_062400 was reduced in the active TB patient group (n = 31) vs healthy patient group (n = 30)." 1 Signature of circular RNAs in peripheral blood mononuclear cells from patients with active tuberculosis. - - hsa_circRNA_101128 DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" down-regulated "hsa_circRNA_103017, hsa_circRNA_059914 and hsa_circRNA_101128 were enhanced, while hsa_circRNA_062400 was reduced in the active TB patient group (n = 31) vs healthy patient group (n = 30)." 1 Signature of circular RNAs in peripheral blood mononuclear cells from patients with active tuberculosis. - - hsa_circRNA_062400 DOID:399 tuberculosis tuberculosis "RT-qPCR, microarray" up-regulated "hsa_circRNA_103017, hsa_circRNA_059914 and hsa_circRNA_101128 were enhanced, while hsa_circRNA_062400 was reduced in the active TB patient group (n = 31) vs healthy patient group (n = 30)." 1 CircRNA fibroblast growth factor receptor 3 promotes tumor progression in non-small cell lung cancer by regulating Galectin-1-AKT/ERK1/2 signaling. - hsa_circ_FGFR3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Here, we used quantitative real-time polymerase chain reaction to validate that circFGFR3 expression was higher in NSCLC tissues than in the paratumor tissues. Furthermore, our study indicated that the forced circFGFR3 expression promoted NSCLC cell invasion and proliferation. Mechanistically, we found that circFGFR3 promoted NSCLC cell invasion and proliferation via competitively combining with miR-22-3p to facilitate the galectin-1 (Gal-1), p-AKT, and p-ERK1/2 expressions. Clinically, we revealed that the high circFGFR3 expression correlates with the poor clinical outcomes in patients with NSCLC. Together, these data provide mechanistic insights into the circFGFR3-mediated regulation of both the AKT and ERK1/2 signaling pathways by sponging miR-22-3p and increasing Gal-1 expression." 1 Expression Profile Analysis of Circular RNAs in Ovarian Endometriosis by Microarray and Bioinformatics. - - circ_103470 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" down-regulated "our results suggest that 2 downregulated circRNAs (circ_103470 and circ_101102) may regulated epithelial-mesenchymal transition in endometriosis via miR-141-5p, which may be a promising therapeutic target in the future." 1 Expression Profile Analysis of Circular RNAs in Ovarian Endometriosis by Microarray and Bioinformatics. - - circ_101102 DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, microarray" down-regulated "our results suggest that 2 downregulated circRNAs (circ_103470 and circ_101102) may regulated epithelial-mesenchymal transition in endometriosis via miR-141-6p, which may be a promising therapeutic target in the future." 1 Circular RNA hsa_circ_0000263 participates in cervical cancer development by regulating target gene of miR-150-5p. hsa_circ_0000263 hsa_circ_TCONS_00017720 - DOID:4362 cervical cancer cervical cancer "RT-qPCR, microarray" up-regulated "We found that hsa_circ_0000263 was significantly upregulated in cervical cancer cells. In addition, the knockdown of hsa_circ_0000263, would inhibit cell proliferation and migration ability. In conclusion, our current research reveals the important role of hsa_circ_0000263/miR-150-5p/MDM4/p53 regulatory network in cervical cancer and provides a new insight into the pathogenesis of cervical cancer." 2 Circ-ZNF609 promotes migration of colorectal cancer by inhibiting Gli1 expression via microRNA-150. hsa_circ_0000615 hsa_circ_ZNF609 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ-ZNF609 regulates Gli1 expression via microRNA-150, thus affecting the migration of colorectal cancer." 3 "Involvement of circular RNA SMARCA5/microRNA-620 axis in the regulation of cervical cancer cell proliferation, invasion and migration." hsa_circ_0001445 hsa_circ_SMARCA5 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "The results indicated that circSMARCA5 was downregulated in CC; overexpression of circSMARCA5 inhibited CC cell proliferation, migration and invasion, and induced cell cycle arrest. In addition, we found that circSMARCA5 could bind to miR-620 and significantly downregulated its expression. Furthermore, the results revealed that circSMARCA5 suppressed proliferation and invasion by miR-620 in CC." 3 "Circular RNA ciRS-7 correlates with advance disease and poor prognosis, and its down-regulation inhibits cells proliferation while induces cells apoptosis in non-small cell lung cancer." hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircRNA ciRS-7 overexpression is associated with advanced disease and poor prognosis in NSCLC patients, and the down-regulation of circRNA ciRS-7 inhibits tumor cells proliferation as well as improves cells apoptosis." 5 Has_circ_0008274 promotes cell proliferation and invasion involving AMPK/mTOR signaling pathway in papillary thyroid carcinoma. hsa_circ_0008274 hsa_circ_UGGT2 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated These results demonstrate that increased hsa_circ_0008274 expression modulates hsa_circ_0008274 to enhance PTC cells proliferation and invasion. Hsa_circ_0008274/ AMPK/mTOR axis may be a novel therapeutic candidate target in PTC treatment. 2 Differential circRNA expression profiles in latent human cytomegalovirus infection and validation using clinical samples. hsa_circ_0001445 hsa_circ_SMARCA5 - DOID:0080827 human cytomegalovirus infection human cytomegalovirus infection "RT-qPCR, RNA-seq" down-regulated "Furthermore, a clinical analysis showed that the expression levels of hsa_circ_0001445 and hsa_circ_0001206 were statistically significantly different in HCMV-infected patients vs. normal controls, suggesting that these circRNAs could potentially serve as biomarkers of HCMV-infection.The expression of hsa_circ_0001445 and hsa_circ_0001206 was downregulated during HCMV infection, and both of these differences were statistically significant (P< 0.001)." 1 Differential circRNA expression profiles in latent human cytomegalovirus infection and validation using clinical samples. hsa_circ_0001206 hsa_circ_CRKL - DOID:0080827 human cytomegalovirus infection human cytomegalovirus infection "RT-qPCR, RNA-seq" down-regulated "Furthermore, a clinical analysis showed that the expression levels of hsa_circ_0001445 and hsa_circ_0001206 were statistically significantly different in HCMV-infected patients vs. normal controls, suggesting that these circRNAs could potentially serve as biomarkers of HCMV-infection.The expression of hsa_circ_0001445 and hsa_circ_0001206 was downregulated during HCMV infection, and both of these differences were statistically significant (P< 0.001)." 1 "Novel circular RNA circNF1 acts as a molecular sponge, promoting gastric cancer by absorbing miR-16." - hsa_circ_NF1 - DOID:10534 stomach cancer gastric cancer RNA-seq up-regulated The circNF1 acts as a novel oncogenic circRNA in GC by functioning as a miR-16 sponge. 1 Circular RNA HIPK3 promotes glioma progression by binding to miR-124-3p. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "In summary, we found that overexpression of circ-HIPK3 promotes proliferative and invasive capacities of glioma cells by sponging miR-124-3p to upregulate STAT3 expression." 7 "Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function." - hsa_circ_LRP6 circ_Lrp6 DOID:178 vascular disease vascular disease RT-qPCR up-regulated "The circ_Lrp6 is an intracellular modulator and a natural sponge for miR-145, counterbalancing the functions of the miRNA in VSMCs." 1 Prediction of CircRNA-Disease Associations Using KATZ Model Based on Heterogeneous Networks. hsa_circ_0006054 hsa_circ_KIAA0355 - DOID:9256 colorectal cancer colorectal cancer RNA-seq dysregulated "Furthermore, we analyze the candidate association between hsa_circ_0006054 and colorectal cancer, and results showed that hsa_circ_0006054 may function as miRNA sponge in the carcinogenesis of colorectal cancer." 1 Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease. - - circRNA19591 DOID:0060224 atrial fibrillation atrial fibrillation RNA-seq down-regulated Our findings provide a novel perspective on circRNAs involved in AF due to rheumatic heart disease and establish the foundation for future research of the potential roles of circRNAs in AF. 1 Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease. - - circRNA19596 DOID:0060224 atrial fibrillation atrial fibrillation RNA-seq dysregulated Our findings provide a novel perspective on circRNAs involved in AF due to rheumatic heart disease and establish the foundation for future research of the potential roles of circRNAs in AF. 1 Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease. - - circRNA16175 DOID:0060224 atrial fibrillation atrial fibrillation RNA-seq dysregulated Our findings provide a novel perspective on circRNAs involved in AF due to rheumatic heart disease and establish the foundation for future research of the potential roles of circRNAs in AF. 1 Circular RNA PVT1 acts as a competing endogenous RNA for miR-497 in promoting non-small cell lung cancer progression. hsa_circ_0085553 hsa_circ_PVT1 circPVT1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "We firstly found that circPVT1 was overexpressed in clinical NSCLC tissues and cell lines. NSCLC patients with high expression of circPVT1 exhibited aggressive clinicopathological characteristics and poor prognosis. In vitro assays of the NSCLC cell lines (H1299 and A549 cells) demonstrated that knockdown of circPVT1 inhibited NSCLC cell proliferation and induced NSCLC cell apoptosis. We further found that circPVT1 served as a competing endogenous RNA of miR-497 and indirectly regulated Bcl-2 expression in NSCLC cells. Finally, inhibition of miR-497 abrogated the effects of circPVT1 knockdown in NSCLC cells." 2 RNA sequencing reveals the expression profiles of circRNA and indicates that circDDX17 acts as a tumor suppressor in colorectal cancer. hsa_circ_0002211 hsa_circ_DDX17 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "The results of qRT-PCR for circDDX17 in 60 paired CRC tissues showed that circDDX17 was significantly down-regulated in CRC tissues and associated with unfavorable clinicopathological parameters. In vitro experiments showed that silencing of circDDX17 promoted CRC cell proliferation, migration, invasion, and inhibited apoptosis." 2 Upregulated circular RNA circ_0030235 predicts unfavorable prognosis in pancreatic ductal adenocarcinoma and facilitates cell progression by sponging miR-1253 and miR-1294. hsa_circ_0030235 hsa_circ_RCBTB2 circ_0030235 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated "As a result, the data documented that circ_0030235 was upregulated in PDAC cell lines and cancerous tissues compared with HPDE. Upregulated circular RNA circ_0030235 predicts unfavorable prognosis in pancreatic ductal adenocarcinoma and facilitates cell progression by sponging miR-1253 and miR-1294." 1 Possible epigenetic regulatory effect of dysregulated circular RNAs in epilepsy. - - mmu_circRNA_002170 DOID:1826 epilepsy epilepsy RT-qPCR up-regulated dysregulated circRNAs might have a pathophysiologic role in chronic epilepsy by regulating multiple disease relevant mRNAs via circRNA-miRNA-mRNA interactions. 1 Possible epigenetic regulatory effect of dysregulated circular RNAs in epilepsy. - - mmu_circRNA_004229 DOID:1826 epilepsy epilepsy RT-qPCR down-regulated dysregulated circRNAs might have a pathophysiologic role in chronic epilepsy by regulating multiple disease relevant mRNAs via circRNA-miRNA-mRNA interactions. 1 Possible epigenetic regulatory effect of dysregulated circular RNAs in epilepsy. - - mmu_circRNA_016800 DOID:1826 epilepsy epilepsy RT-qPCR down-regulated dysregulated circRNAs might have a pathophysiologic role in chronic epilepsy by regulating multiple disease relevant mRNAs via circRNA-miRNA-mRNA interactions. 1 Possible epigenetic regulatory effect of dysregulated circular RNAs in epilepsy. - - mmu_circRNA_31968 DOID:1826 epilepsy epilepsy RT-qPCR down-regulated dysregulated circRNAs might have a pathophysiologic role in chronic epilepsy by regulating multiple disease relevant mRNAs via circRNA-miRNA-mRNA interactions. 1 Possible epigenetic regulatory effect of dysregulated circular RNAs in epilepsy. - - mmu_circRNA_35542 DOID:1826 epilepsy epilepsy RT-qPCR down-regulated dysregulated circRNAs might have a pathophysiologic role in chronic epilepsy by regulating multiple disease relevant mRNAs via circRNA-miRNA-mRNA interactions. 1 Comprehensive circular RNA profiling of proliferative vitreoretinopathy and its clinical significance. hsa_circ_0043144 hsa_circ_CCL3 circ_0043144 DOID:9720 vitreous disease proliferative vitreoretinopathy "RT-qPCR, microarray" up-regulated "The circ_0043144 is a promising prognostic and diagnostic indicator for PVR diseases.Collectively, this study indicates that circRNAs are potential regulators of the pathogenesis of PVR. circ_0043144 is a promising prognostic and diagnostic indicator for PVR diseases." 1 A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation. hsa_circ_0051778 hsa_circ_BCAT2 - DOID:7608 parathyroid adenoma parathyroid adenoma microarray up-regulated "Among upregulated circRNAs; hsa_cirRNA_051778, hsa_cirRNA_402533, hsa_cirRNA_406174, and hsa_cirRNA_0008267 showed the highest fold-change (>5-fold), whereas hsa_circRNA_032603 and hsa_circRNA_058097 showed the highest fold-change (>3-fold) among the downregulated circRNAs." 1 A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation. - - hsa-circRNA_402533 DOID:7608 parathyroid adenoma parathyroid adenoma microarray up-regulated "Among upregulated circRNAs; hsa_cirRNA_051778, hsa_cirRNA_402533, hsa_cirRNA_406174, and hsa_cirRNA_0008267 showed the highest fold-change (>5-fold), whereas hsa_circRNA_032603 and hsa_circRNA_058097 showed the highest fold-change (>3-fold) among the downregulated circRNAs." 1 A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation. hsa_circ_0005622 hsa_circ_PITPNB - DOID:7608 parathyroid adenoma parathyroid adenoma microarray up-regulated "Among upregulated circRNAs; hsa_cirRNA_051778, hsa_cirRNA_402533, hsa_cirRNA_406174, and hsa_cirRNA_0008267 showed the highest fold-change (>5-fold), whereas hsa_circRNA_032603 and hsa_circRNA_058097 showed the highest fold-change (>3-fold) among the downregulated circRNAs." 1 A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation. hsa_circ_0008267 hsa_circ_SDHAP2 - DOID:7608 parathyroid adenoma parathyroid adenoma microarray up-regulated "Among upregulated circRNAs; hsa_cirRNA_051778, hsa_cirRNA_402533, hsa_cirRNA_406174, and hsa_cirRNA_0008267 showed the highest fold-change (>5-fold), whereas hsa_circRNA_032603 and hsa_circRNA_058097 showed the highest fold-change (>3-fold) among the downregulated circRNAs." 1 A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation. hsa_circ_0032603 hsa_circ_LTBP2 - DOID:7608 parathyroid adenoma parathyroid adenoma microarray down-regulated "Among upregulated circRNAs; hsa_cirRNA_051778, hsa_cirRNA_402533, hsa_cirRNA_406174, and hsa_cirRNA_0008267 showed the highest fold-change (>5-fold), whereas hsa_circRNA_032603 and hsa_circRNA_058097 showed the highest fold-change (>3-fold) among the downregulated circRNAs." 1 A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation. hsa_circ_0058097 hsa_circ_FN1 - DOID:7608 parathyroid adenoma parathyroid adenoma microarray down-regulated "Among upregulated circRNAs; hsa_cirRNA_051778, hsa_cirRNA_402533, hsa_cirRNA_406174, and hsa_cirRNA_0008267 showed the highest fold-change (>5-fold), whereas hsa_circRNA_032603 and hsa_circRNA_058097 showed the highest fold-change (>3-fold) among the downregulated circRNAs." 1 Circular RNA Vav3 sponges gga-miR-375 to promote epithelial-mesenchymal transition. - gga_circ_Vav3 circ-Vav3 DOID:3571 liver cancer liver tumors RNA-seq up-regulated "In this study, circRNA sequencing results revealed that a circRNA Vav3 termed circ-Vav3 was upregulated in the liver tumors of chickens infected with ALV-J. We further confirmed that the circ-Vav3/gga-miR-375/YAP1 axis induces epithelial-mesenchymal transition (EMT) through influencing EMT markers to promote tumorigenesis." 1 Up-regulation of circ-SMAD7 inhibits tumor proliferation and migration in esophageal squamous cell carcinoma. - hsa_circ_SMAD7 circ-SMAD7 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR down-regulated "Our study firstly exposed that over-expressioncirc-SMAD7, an influential regulator in cancer progression, can inhibit tumor proliferation and migration in ESCC and have the potential of becoming a biomarker for the diagnosis and therapy of ESCC." 1 Silencing of circ_0009910 inhibits acute myeloid leukemia cell growth through increasing miR-20a-5p. hsa_circ_0009910 hsa_circ_MFN2 - DOID:9119 acute myeloid leukemia acute myeloid leukemia RNA-seq up-regulated Our findings firstly identify that circ_0009910 is significantly upregulated in AML bone marrow samples and might serve as a novel outcome biomarker for AML. Both circ_0009910 and miR-20a-5p may be potential therapeutic targets for future AML treatment. 3 A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p. - hsa_circ_NCX1 - DOID:114 heart disease ischemic myocardial injury RT-qPCR up-regulated "Our findings reveal a novel regulatory pathway that comprises circNCX1, miR-133a-3p and CDIP1, that is involved in cardiomyocyte apoptosis. This pathway may serve as a potential therapeutic avenue for ischemic heart diseases." 1 "Circular RNA microarray expression profile in 3,4-benzopyrene/angiotensin II-induced abdominal aortic aneurysm in mice." - - circRNA_009839 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, microarray" up-regulated This study performed circRNA expression profiling in AAA and the results specifically predicted the regulatory role of circRNAs in AAA pathogenesis. 1 "Circular RNA microarray expression profile in 3,4-benzopyrene/angiotensin II-induced abdominal aortic aneurysm in mice." - - circRNA_009537 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, microarray" up-regulated This study performed circRNA expression profiling in AAA and the results specifically predicted the regulatory role of circRNAs in AAA pathogenesis. 1 "Circular RNA microarray expression profile in 3,4-benzopyrene/angiotensin II-induced abdominal aortic aneurysm in mice." - - circRNA_004742 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, microarray" up-regulated This study performed circRNA expression profiling in AAA and the results specifically predicted the regulatory role of circRNAs in AAA pathogenesis. 1 "Circular RNA microarray expression profile in 3,4-benzopyrene/angiotensin II-induced abdominal aortic aneurysm in mice." - - circRNA_014193 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, microarray" up-regulated This study performed circRNA expression profiling in AAA and the results specifically predicted the regulatory role of circRNAs in AAA pathogenesis. 1 "Circular RNA microarray expression profile in 3,4-benzopyrene/angiotensin II-induced abdominal aortic aneurysm in mice." - - circRNA_002856 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, microarray" up-regulated This study performed circRNA expression profiling in AAA and the results specifically predicted the regulatory role of circRNAs in AAA pathogenesis. 1 "Circular RNA microarray expression profile in 3,4-benzopyrene/angiotensin II-induced abdominal aortic aneurysm in mice." - - circRNA_002813 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, microarray" down-regulated This study performed circRNA expression profiling in AAA and the results specifically predicted the regulatory role of circRNAs in AAA pathogenesis. 1 "Circular RNA microarray expression profile in 3,4-benzopyrene/angiotensin II-induced abdominal aortic aneurysm in mice." - - circRNA_013683 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, microarray" down-regulated This study performed circRNA expression profiling in AAA and the results specifically predicted the regulatory role of circRNAs in AAA pathogenesis. 1 "Circular RNA microarray expression profile in 3,4-benzopyrene/angiotensin II-induced abdominal aortic aneurysm in mice." - - circRNA_018331 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, microarray" down-regulated This study performed circRNA expression profiling in AAA and the results specifically predicted the regulatory role of circRNAs in AAA pathogenesis. 1 "Circular RNA microarray expression profile in 3,4-benzopyrene/angiotensin II-induced abdominal aortic aneurysm in mice." - - circRNA_015216 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, microarray" up-regulated This study performed circRNA expression profiling in AAA and the results specifically predicted the regulatory role of circRNAs in AAA pathogenesis. 1 "Circular RNA microarray expression profile in 3,4-benzopyrene/angiotensin II-induced abdominal aortic aneurysm in mice." - - circRNA_001265 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, microarray" down-regulated This study performed circRNA expression profiling in AAA and the results specifically predicted the regulatory role of circRNAs in AAA pathogenesis. 1 Interpreting Non-coding Genetic Variation in Multiple Sclerosis Genome-Wide Associated Regions. hsa_circ_0043813 hsa_circ_STAT3 - DOID:2377 multiple sclerosis multiple sclerosis RNA-seq up-regulated "this work showed for the first time that MS-GWAS top hits map in LD blocks enriched in circRNAs, suggesting circRNAs as possible novel contributors to the disease pathogenesis." 1 The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression. hsa_circ_0058514 hsa_circ_AGFG1 - DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, RNA-seq" up-regulated "circAGFG1 was evidently up-regulated in TNBC, and its level was correlated with clinical stage, pathological grade and poor prognosis of patients with TNBC. The results indicated that circAGFG1 could promote TNBC cell proliferation, mobility and invasion as well as tumorigenesis and metastasis in vivo. Mechanistic analysis showed that circAGFG1 may act as a ceRNA (competing endogenous RNA) of miR-195-5p to relieve the repressive effect of miR-195-5p on its target cyclin E1 (CCNE1)." 1 MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change. - hsa_circ_DICER1 circ-DICER1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "MOV10 / circ-DICER1 / miR-103a-3p (miR-382-5p) / ZIC4 pathway plays a vital role in regulating the angiogenesis of glioma. Our findings not only provides novel mechanisms for the angiogenesis of glioma, but also provide potential targets for anti-angiogenesis therapies of glioma." 1 circARF3 Alleviates Mitophagy-Mediated Inflammation by Targeting miR-103/TRAF3 in Mouse Adipose Tissue - hsa_circ_ARF3 - DOID:0060611 abdominal obesity-metabolic syndrome adipose inflammation RT-qPCR down-regulated The circARF3 Alleviates Mitophagy-Mediated Inflammation by Targeting miR-103/TRAF3 in Mouse Adipose Tissue 1 Microarray expression profile of circular RNAs and mRNAs in children with systemic lupus erythematosus. hsa_circ_0021372 hsa_circ_RPS13 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated "Among these SLE patients, we detected that the hsa_circ_0021372 and hsa_circ_0075699 levels are associated with C3 and C4 levels in children with SLE. The hsa_circ_0057762 level is positively associated with the SLEDAI-2K score. The ROC curves of circRNAs showed that the levels of hsa_circ_0057762 (AUC 0.804, 95% CI 0.607-1.0, P = 0.02) and hsa_circ_0003090 (AUC 0.848, 95% CI 0.688-1.0, P = 0.008) could differentiate the patients with SLE from the healthy controls. " 1 Microarray expression profile of circular RNAs and mRNAs in children with systemic lupus erythematosus. hsa_circ_0057762 hsa_circ_STRADB - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" down-regulated "Among these SLE patients, we detected that the hsa_circ_0021372 and hsa_circ_0075699 levels are associated with C3 and C4 levels in children with SLE. The hsa_circ_0057762 level is positively associated with the SLEDAI-2K score. The ROC curves of circRNAs showed that the levels of hsa_circ_0057762 (AUC 0.804, 95% CI 0.607-1.0, P = 0.02) and hsa_circ_0003090 (AUC 0.848, 95% CI 0.688-1.0, P = 0.009) could differentiate the patients with SLE from the healthy controls." 1 Microarray expression profile of circular RNAs and mRNAs in children with systemic lupus erythematosus. hsa_circ_0075699 hsa_circ_FAM8A1 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated "Among these SLE patients, we detected that the hsa_circ_0021372 and hsa_circ_0075699 levels are associated with C3 and C4 levels in children with SLE. The hsa_circ_0057762 level is positively associated with the SLEDAI-2K score. The ROC curves of circRNAs showed that the levels of hsa_circ_0057762 (AUC 0.804, 95% CI 0.607-1.0, P = 0.02) and hsa_circ_0003090 (AUC 0.848, 95% CI 0.688-1.0, P = 0.010) could differentiate the patients with SLE from the healthy controls." 1 Microarray expression profile of circular RNAs and mRNAs in children with systemic lupus erythematosus. hsa_circ_0003090 hsa_circ_PLAUR - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" down-regulated "Among these SLE patients, we detected that the hsa_circ_0021372 and hsa_circ_0075699 levels are associated with C3 and C4 levels in children with SLE. The hsa_circ_0057762 level is positively associated with the SLEDAI-2K score. The ROC curves of circRNAs showed that the levels of hsa_circ_0057762 (AUC 0.804, 95% CI 0.607-1.0, P = 0.02) and hsa_circ_0003090 (AUC 0.848, 95% CI 0.688-1.0, P = 0.011) could differentiate the patients with SLE from the healthy controls." 1 RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers. hsa_circ_0001178 hsa_circ_USP25 circRNA_0001178 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated the results of our study revealed the expression profiles and potential functions of differentially expressed circRNAs in traumatic SCI in rats; this may provide new clues for studying the mechanisms underlying SCI and also present novel molecular targets for clinical therapy of SCI. 3 RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers. hsa_circ_0000826 hsa_circ_ANKRD12 circRNA_0000826 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated the results of our study revealed the expression profiles and potential functions of differentially expressed circRNAs in traumatic SCI in rats; this may provide new clues for studying the mechanisms underlying SCI and also present novel molecular targets for clinical therapy of SCI. 3 Inhibition of hsa_circ_0001313 (circCCDC66) induction enhances the radio-sensitivity of colon cancer cells via tumor suppressor miR-338-3p: Effects of cicr_0001313 on colon cancer radio-sensitivity. hsa_circ_0001313 hsa_circ_CCDC66 - DOID:219 colon cancer colon cancer RT-qPCR up-regulated These findings revealed that knockdown of circ_0001313 could induce radio-sensitivity of colon cancer cells by negatively regulating miR-338-3p. 2 Three isoforms of exosomal circPTGR1 promote hepatocellular carcinoma metastasis via the miR449a-MET pathway. - hsa_circ_PTGR1 circPTGR1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq up-regulated Three isoforms of exosomal circPTGR1 promote hepatocellular carcinoma metastasis via the miR449a-MET pathway. 1 CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR-8075. - - hsa_circRNA_101996 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR-8075. 1 Antitumor effects of circ-EPHB4 in hepatocellular carcinoma via inhibition of HIF-1alpha. - hsa_circ_EPHB4 circ-EPHB4 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated The circ-EPHB4 is a tumor inhibitor in HCC and functions by inhibiting HIF-1alpha expression. 1 A circular RNA hsa_circ_0079929 inhibits tumor growth in hepatocellular carcinoma. hsa_circ_0079929 hsa_circ_CDK13 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated Our study shows that tumor suppressive role of hsa_circ_0079299 in HCC provides new recognition of circRNAs in cancers. 1 circRNA of AR-suppressed PABPC1 91 bp enhances the cytotoxicity of natural killer cells against hepatocellular carcinoma via upregulating UL16 binding protein 1. hsa_circ_0085154 hsa_circ_ARSP91 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "In conclusion, CircARSP91 could enhance innate immune surveillance by strengthening the cytotoxicity of NK cells, implying that circRNA may serve a role in tumor immunity." 2 Circular RNA circASS1 is downregulated in breast cancer cells MDA-MB-231 and suppressed invasion and migration. - hsa_circ_ASS1 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated CircASS1 suppresses invasion and migration capacity of breast cancer cells and harbored miR-4443. 1 Circular RNA circ-PRKCI functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-3680-3p in esophageal squamous cell carcinoma. - hsa_circ_PRKCI circ-PRKCI DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated The circ-PRKCI/miR-3680-3p/AKT3 regulatory network plays an important role in esophageal squamous cell carcinoma and that provide new insights into the pathogenesis of esophageal squamous cell carcinoma. 2 "Circ5379-6, a circular form of tumor suppressor PPARalpha, participates in the inhibition of hepatocellular carcinoma tumorigenesis and metastasis." - - circ5379-6 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "We showed that the overexpression of circ5379-6 decreased cell proliferation, inhibited cell migration and invasion, and induced cell apoptosis in the HCC cell lines. Consistently, in vivo studies in nude mice confirmed that the overexpression of circ5379-6 effectively inhibited the tumorigenesis and metastasis of HCC. We conclude that circ5379-6 plays a role similar to its linear counterpart PPARalpha to inhibit HCC tumorigenesis and progression." 1 Circular RNA circ_0001946 acts as a competing endogenous RNA to inhibit glioblastoma progression by modulating miR-671-5p and CDR1. hsa_circ_0001946 hsa_circ_CDR1 circ_0001946 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, microarray" down-regulated "Our study confirmed that the circ_0001946/miR-671-5p/ CDR1 pathway modulates the development of GBM, and this pathway might be a promising target for the development of therapeutics for GBM." 2 Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer. hsa_circ_0011385 hsa_circ_EIF3I circRNA 100146 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated "Our collective findings support a role of circRNA 100146 in the development of NSCLC and further demonstrate endogenous competition among circRNA 100146, SF3B3 and miRNAs, providing novel insights into the mechanisms underlying non-small cell lung cancer." 1 NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling. - hsa_circ_NSD2 circ-NSD2 DOID:9256 colorectal cancer colorectal cancer RNA-seq up-regulated "Our findings highlight a novel oncogenic function of circ-NSD2 and uncover a key mechanism for the circ-NSD2/miR-199b-5p/DDR1/JAG1 axis in CRC metastasis, which may serve as a prognostic factor and therapeutic target for antimetastatic therapy in CRC patients." 1 Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p. - hsa_circ_EBLN3 hsa_circ_001783 DOID:1612 breast cancer breast cancer microarray up-regulated The hsa_circ_001783 promoted progression of breast cancer cells via sponging miR-200c-3p. 1 Comprehensive circRNA expression profile during ischemic postconditioning attenuating hepatic ischemia/reperfusion injury. - - mmu_circRNA_005186 DOID:409 liver disease hepatic ischemia/reperfusion injury "RT-qPCR, microarray" up-regulated The circRNAs are closely related to hepatic I/R injury and IPO and suggests that targeting mmu_circRNA_005186-miR-124-3p-Epha2 pathway might attenuate hepatic I/R injury. 1 Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma. - hsa_circ_ZNF609 circ-ZNF609 DOID:3247 rhabdomyosarcoma rhabdomyosarcoma "RT-qPCR, RNA-seq" up-regulated Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma. 1 Hsa_circRNA_0059655 plays a role in salivary adenoid cystic carcinoma by functioning as a sponge of miR-338-3p. hsa_circ_0059655 hsa_circ_PYGB - DOID:4866 salivary gland adenoid cystic carcinoma salivary adenoid cystic carcinoma "RT-qPCR, microarray" up-regulated "The ceRNA regulatory network analysis showed that hsa_circ_0059655 and other 14 circRNAs derived from PYGB target on several similar genes by miR-338-3p. Among the 15 circRNAs derived from PYGB, hsa_circ_0059655 has the most relationships in the ceRNA network. Furthermore, after hsa_circ_0059655 was knocked down in SACC-83 cells, the expression of hsa-miR-338-3p was up-regulated while CCND1 was down-regulated. The proliferation, migration, and invasion of SACC-83 cells also decreased after hsa_circ_0059655 knock-downed." 1 Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:5041 esophageal cancer esophageal cancer "RT-qPCR, microarray" down-regulated "Hsa_circ_0001946 was confirmed to predict the recurrence, overall survival (OS) and disease-free survival (DFS) in frozen and FFPE tissues, while its overexpression decreased cell proliferation, migration, and invasion." 1 Circular RNA hsa_circ_0078602 may have potential as a prognostic biomarker for patients with hepatocellular carcinoma. hsa_circ_0078602 hsa_circ_SLC22A1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated The results supported the conclusion that circ_0078602 was downregulated in HCC tissue compared with non-cancerous tissue (P=0.015) and exhibited diagnostic potential. 1 Circular RNA hsa_circ_0078602 may have potential as a prognostic biomarker for patients with hepatocellular carcinoma. hsa_circ_0018764 hsa_circ_OIT3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "Attention was then focused on the top four circRNAs whose expression levels were reduced in HCC tissues as compared with non-cancerous tissues. Additionally, RNA expression was validated in 30 matched tissue samples using reverse transcription-quantitative polymerase chain reaction. The results revealed that the expression levels of hsa_circ_0078602 and hsa_circ_0018764 were consistent with microarray analysis (P<0.05)." 1 Circular RNA hsa_circ_0007059 indicates prognosis and influences malignant behavior via AKT/mTOR in oral squamous cell carcinoma. hsa_circ_0007059 hsa_circ_ZNF720 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated Circular RNA hsa_circ_0007059 indicates prognosis and influences malignant behavior via AKT/mTOR in oral squamous cell carcinoma. 1 Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats. - - circRNA_07079 DOID:319 spinal cord disease spinal cord injury "RT-qPCR, RNA-seq" up-regulated the results of our study revealed the expression profiles and potential functions of differentially expressed circRNAs in traumatic SCI in rats; this may provide new clues for studying the mechanisms underlying SCI and also present novel molecular targets for clinical therapy of SCI. 1 Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats. - - circRNA_01282 DOID:319 spinal cord disease spinal cord injury "RT-qPCR, RNA-seq" up-regulated the results of our study revealed the expression profiles and potential functions of differentially expressed circRNAs in traumatic SCI in rats; this may provide new clues for studying the mechanisms underlying SCI and also present novel molecular targets for clinical therapy of SCI. 1 Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats. - - circRNA_11070 DOID:319 spinal cord disease spinal cord injury "RT-qPCR, RNA-seq" up-regulated the results of our study revealed the expression profiles and potential functions of differentially expressed circRNAs in traumatic SCI in rats; this may provide new clues for studying the mechanisms underlying SCI and also present novel molecular targets for clinical therapy of SCI. 1 Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats. - - circRNA_08027 DOID:319 spinal cord disease spinal cord injury "RT-qPCR, RNA-seq" up-regulated the results of our study revealed the expression profiles and potential functions of differentially expressed circRNAs in traumatic SCI in rats; this may provide new clues for studying the mechanisms underlying SCI and also present novel molecular targets for clinical therapy of SCI. 1 Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats. - - circRNA_01373 DOID:319 spinal cord disease spinal cord injury "RT-qPCR, RNA-seq" down-regulated the results of our study revealed the expression profiles and potential functions of differentially expressed circRNAs in traumatic SCI in rats; this may provide new clues for studying the mechanisms underlying SCI and also present novel molecular targets for clinical therapy of SCI. 1 Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats. - - circRNA_06211 DOID:319 spinal cord disease spinal cord injury "RT-qPCR, RNA-seq" down-regulated the results of our study revealed the expression profiles and potential functions of differentially expressed circRNAs in traumatic SCI in rats; this may provide new clues for studying the mechanisms underlying SCI and also present novel molecular targets for clinical therapy of SCI. 1 Hsa_circ_0067997 promotes the progression of gastric cancer by inhibition of miR-515-5p and activation of X chromosome-linked inhibitor of apoptosis (XIAP). hsa_circ_0067997 hsa_circ_FNDC3B circ_0067997 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_0067997 was identified to be an oncogene in GC by regulating miR-515-5p/XIAP axis. 4 Circular RNA hsa_circRNA_102958 may serve as a diagnostic marker for gastric cancer. - - hsa_circRNA_102958 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "In this study, we analyzed 30 patients and found that hsa_circRNA_102958 was significantly overexpressed in gastric cancer tissues compared with paired adjacent normal tissues. Clinicopathological features showed that hsa_circRNA_102958 level in GC tissues was positively associated with TNM stage (p= 0.032). The area under the ROC curve was 0.74. Finally, a total of 5 miRNAs were predicted to have an interaction with hsa_circRNA_102958." 1 circRNA33186 Contributes to the Pathogenesis of Osteoarthritis by Sponging miR-127-5p. - hsa_circ_Umad1 circRNA.33186 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated The circRNA.33186 Contributes to the Pathogenesis of Osteoarthritis by Sponging miR-127-5p. 1 Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance. hsa_circ_0001258 hsa_circ_PPP6R2 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" down-regulated Our findings may provide new evidence for the underlying mechanism of OS chemo-resistance and uncover some novel targets for reversing it. 1 The circular RNome of primary breast cancer. - hsa_circ_CNOT2 - DOID:1612 breast cancer breast cancer RNA-seq up-regulated "The circRNAs are abundantly present, show characteristics of being specifically regulated, are associated with clinical and biological properties, and thus are relevant in breast cancer." 2 Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury. - - rno_circRNA_005342 DOID:319 spinal cord disease traumatic spinal cord injury "RT-qPCR, microarray" down-regulated "five selected circRNAs, namely, rno_circRNA_005342, rno_circRNA_015513, rno_circRNA_002948, rno_circRNA_006096, and rno_circRNA_013017 were all significantly downregulated in the SCI group after verification by qRT-PCR, demonstrating a similar expression pattern in both microarray and PCR data." 1 Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury. - - rno_circRNA_015513 DOID:319 spinal cord disease traumatic spinal cord injury "RT-qPCR, microarray" down-regulated "five selected circRNAs, namely, rno_circRNA_005342, rno_circRNA_015513, rno_circRNA_002948, rno_circRNA_006096, and rno_circRNA_013017 were all significantly downregulated in the SCI group after verification by qRT-PCR, demonstrating a similar expression pattern in both microarray and PCR data." 1 Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury. - - rno_circRNA_002948 DOID:319 spinal cord disease traumatic spinal cord injury "RT-qPCR, microarray" down-regulated "five selected circRNAs, namely, rno_circRNA_005342, rno_circRNA_015513, rno_circRNA_002948, rno_circRNA_006096, and rno_circRNA_013017 were all significantly downregulated in the SCI group after verification by qRT-PCR, demonstrating a similar expression pattern in both microarray and PCR data." 1 Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury. - - rno_circRNA_006096 DOID:319 spinal cord disease traumatic spinal cord injury "RT-qPCR, microarray" down-regulated "five selected circRNAs, namely, rno_circRNA_005342, rno_circRNA_015513, rno_circRNA_002948, rno_circRNA_006096, and rno_circRNA_013017 were all significantly downregulated in the SCI group after verification by qRT-PCR, demonstrating a similar expression pattern in both microarray and PCR data." 1 Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury. - - rno_circRNA_013017 DOID:319 spinal cord disease traumatic spinal cord injury "RT-qPCR, microarray" down-regulated "five selected circRNAs, namely, rno_circRNA_005342, rno_circRNA_015513, rno_circRNA_002948, rno_circRNA_006096, and rno_circRNA_013017 were all significantly downregulated in the SCI group after verification by qRT-PCR, demonstrating a similar expression pattern in both microarray and PCR data." 1 Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family. hsa_circ_0000977 hsa_circ_NOL10 - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "circNOL10 also affects mitochondrial function through regulating the humanin polypeptide family and affecting multiple signaling pathways, ultimately inhibiting cell proliferation and cell cycle progression, and promoting the apoptosis of lung cancer cells, thereby inhibiting lung cancer development." 1 Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection. - - circRNA1001 DOID:934 viral infectious disease orf virus infection "RT-qPCR, RNA-seq" down-regulated "The results indicated that circRNA1001, circRNA1684 and circRN3127 were down-regulated while circRNA7880 was up-regulated, which were consistent with the RNA-seq data" 1 Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection. - - circRNA1684 DOID:934 viral infectious disease orf virus infection "RT-qPCR, RNA-seq" down-regulated "The results indicated that circRNA1001, circRNA1684 and circRN3127 were down-regulated while circRNA7880 was up-regulated, which were consistent with the RNA-seq data" 1 Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection. - - circRNA3127 DOID:934 viral infectious disease orf virus infection "RT-qPCR, RNA-seq" down-regulated "The results indicated that circRNA1001, circRNA1684 and circRN3127 were down-regulated while circRNA7880 was up-regulated, which were consistent with the RNA-seq data" 1 Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection. - - circRNA7880 DOID:934 viral infectious disease orf virus infection "RT-qPCR, RNA-seq" up-regulated "The results indicated that circRNA1001, circRNA1684 and circRN3127 were down-regulated while circRNA7880 was up-regulated, which were consistent with the RNA-seq data" 1 Novel circular RNA expression profile of uveal melanoma revealed by microarray. hsa_circ_0119873 hsa_circ_RASGRP3 - DOID:6039 uveal melanoma uveal melanoma "RT-qPCR, microarray" up-regulated "We used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data, including hsa_circ_0119873, hsa_circ_0128533, hsa_circ_0047924, hsa_circ_0103232, hsa-circRNA10628-6, hsa_circ_0032148 and hsa_circ_0133460, which may be promising candidates to study future molecular mechanisms." 1 Novel circular RNA expression profile of uveal melanoma revealed by microarray. hsa_circ_0128533 hsa_circ_MYO10 - DOID:6039 uveal melanoma uveal melanoma "RT-qPCR, microarray" up-regulated "We used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data, including hsa_circ_0119873, hsa_circ_0128533, hsa_circ_0047924, hsa_circ_0103232, hsa-circRNA10628-6, hsa_circ_0032148 and hsa_circ_0133460, which may be promising candidates to study future molecular mechanisms." 1 Novel circular RNA expression profile of uveal melanoma revealed by microarray. hsa_circ_0047924 hsa_circ_RTTN - DOID:6039 uveal melanoma uveal melanoma "RT-qPCR, microarray" up-regulated "We used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data, including hsa_circ_0119873, hsa_circ_0128533, hsa_circ_0047924, hsa_circ_0103232, hsa-circRNA10628-6, hsa_circ_0032148 and hsa_circ_0133460, which may be promising candidates to study future molecular mechanisms." 1 Novel circular RNA expression profile of uveal melanoma revealed by microarray. hsa_circ_0103232 hsa_circ_OCA2 - DOID:6039 uveal melanoma uveal melanoma "RT-qPCR, microarray" up-regulated "We used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data, including hsa_circ_0119873, hsa_circ_0128533, hsa_circ_0047924, hsa_circ_0103232, hsa-circRNA10628-6, hsa_circ_0032148 and hsa_circ_0133460, which may be promising candidates to study future molecular mechanisms." 2 Novel circular RNA expression profile of uveal melanoma revealed by microarray. - hsa_circ_OCA2 hsa-circRNA10628-6 DOID:6039 uveal melanoma uveal melanoma "RT-qPCR, microarray" up-regulated "We used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data, including hsa_circ_0119873, hsa_circ_0128533, hsa_circ_0047924, hsa_circ_0103232, hsa-circRNA10628-6, hsa_circ_0032148 and hsa_circ_0133460, which may be promising candidates to study future molecular mechanisms." 2 Novel circular RNA expression profile of uveal melanoma revealed by microarray. hsa_circ_0032148 hsa_circ_KCNH5 - DOID:6039 uveal melanoma uveal melanoma "RT-qPCR, microarray" down-regulated "We used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data, including hsa_circ_0119873, hsa_circ_0128533, hsa_circ_0047924, hsa_circ_0103232, hsa-circRNA10628-6, hsa_circ_0032148 and hsa_circ_0133460, which may be promising candidates to study future molecular mechanisms." 1 Novel circular RNA expression profile of uveal melanoma revealed by microarray. hsa_circ_0133460 hsa_circ_DGKI - DOID:6039 uveal melanoma uveal melanoma "RT-qPCR, microarray" down-regulated "We used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data, including hsa_circ_0119873, hsa_circ_0128533, hsa_circ_0047924, hsa_circ_0103232, hsa-circRNA10628-6, hsa_circ_0032148 and hsa_circ_0133460, which may be promising candidates to study future molecular mechanisms." 1 Upregulated circular RNA circ_0025033 promotes papillary thyroid cancer cell proliferation and invasion via sponging miR-1231 and miR-1304. hsa_circ_0025033 hsa_circ_FOXM1 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated Upregulated circular RNA circ_0025033 promotes papillary thyroid cancer cell proliferation and invasion via sponging miR-1231 and miR-1304. 2 Circular RNA expression profiles of peripheral blood mononuclear cells in hepatocellular carcinoma patients by sequence analysis. hsa_circ_0000798 hsa_circ_BPTF circ_0000798 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated Dysregulated circ_0000798 in PBMCs has potential as a convenient biomarker for diagnosing or prognosticating HCC. 1 Using circular RNA SMARCA5 as a potential novel biomarker for hepatocellular carcinoma. - hsa_circ_SMARCA5 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Our study revealed that circSMARCA5 may promote apoptosis, inhibit proliferation, invasion and metastasis of HCC cells. CircSMARCA5 may serve as a potential prediction and monitor biomarker for HCC, especially in HCC patients with AFP blow the cutoff value." 3 Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. - - circNRIP1 DOID:10534 stomach cancer gastric cancer RNA-seq up-regulated The circNRIP1 sponges miR-149-5p to affect the expression level of AKT1 and eventually acts as a tumour promotor in GC. 1 Enhanced expression of circ_0000267 in hepatocellular carcinoma indicates poor prognosis and facilitates cell progression by sponging miR-646. hsa_circ_0000267 hsa_circ_FAM53B - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Enhanced expression of circ_0000267 in hepatocellular carcinoma indicates poor prognosis and facilitates cell progression by sponging miR-646. 3 Circular RNA ARHGAP26 is over-expressed and its downregulation inhibits cell proliferation and promotes cell apoptosis in gastric cancer cells. - hsa_circ_ARHGAP26 circ-ARHGAP26 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated The circ-ARHGAP26 is over-expressed and its downregulation inhibits cell proliferation and promotes cells apoptosis in GC cells. 3 Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis. - - circRNA-28028 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" up-regulated "The results demonstrated that five circRNAs (circRNA-28028, circRNA-29981, circRNA-004372, circRNA-0043021 and circRNA-36096) were upregulated." 1 Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis. - - circRNA-29981 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" up-regulated "The results demonstrated that five circRNAs (circRNA-28028, circRNA-29981, circRNA-004372, circRNA-0043021 and circRNA-36096) were upregulated." 1 Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis. - - circRNA-004372 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" up-regulated "The results demonstrated that five circRNAs (circRNA-28028, circRNA-29981, circRNA-004372, circRNA-0043021 and circRNA-36096) were upregulated." 1 Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis. hsa_circ_0043021 hsa_circ_ZNF207 circRNA-0043021 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" up-regulated "The results demonstrated that five circRNAs (circRNA-28028, circRNA-29981, circRNA-004372, circRNA-0043021 and circRNA-36096) were upregulated." 1 Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis. - - circRNA-36096 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" up-regulated "The results demonstrated that five circRNAs (circRNA-28028, circRNA-29981, circRNA-004372, circRNA-0043021 and circRNA-36096) were upregulated." 1 Circular RNA hsa_circ_103809 suppresses hepatocellular carcinoma proliferation and invasion by sponging miR-620. - - hsa_circ_103809 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Hsa_circ_103809 acts by binding to miR-620 and inhibiting the tumourigenicity of HCC. Thus, this circRNA may serve as a potential biomarker and novel therapeutic target of HCC." 1 circOMA1-Mediated miR-145-5p Suppresses Tumor Growth of Nonfunctioning Pituitary Adenomas by Targeting TPT1. - - circOMA1 DOID:3829 pituitary adenoma pituitary adenoma RT-qPCR up-regulated "CircOMA1 promotes NFPA progression by acting as the sponge of tumor suppressor miR-145-5p to regulate the TPT1 signaling pathway, revealing a therapeutic target in preventing the tumorigenesis of NFPAs." 1 Circular RNA circ-RAD23B promotes cell growth and invasion by miR-593-3p/CCND2 and miR-653-5p/TIAM1 pathways in non-small cell lung cancer. - hsa_circ_RAD23B - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ-RAD23B promotes cell growth and invasion by miR-593-3p/CCND2 and miR-653-5p/TIAM1 pathways in non-small cell lung cancer. 3 The circINTS4/miR-146b/CARMA3 axis promotes tumorigenesis in bladder cancer. - hsa_circ_INTS4 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated The circINTS4/miR-146b/CARMA3 axis might serve as a promising therapeutic target for BC intervention. 1 CircRNA circ_0000190 inhibits the progression of multiple myeloma through modulating miR-767-5p/MAPK4 pathway. hsa_circ_0000190 hsa_circ_CNIH4 - DOID:9538 multiple myeloma multiple myeloma RT-qPCR down-regulated "The ability of circ_0000190 to protect against MM was inherited through repression of miR-767-5p, and miR-767-5p might be a tumor drive through targeting MAPK4." 2 hsa_circ_0081143 promotes cisplatin resistance in gastric cancer by targeting miR-646/CDK6 pathway. hsa_circ_0081143 hsa_circ_COL1A2 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated Our study indicated a novel regulatory loop that hsa_circ_0081143/miR-646/CDK6 axis in GC progression. These data suggested that hsa_circ_0081143 might act as a potential novel therapeutic strategy for GC treatment. 3 Widespread and Functional RNA Circularization in Localized Prostate Cancer. - hsa_circ_CSNK1G3 - DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated The circCSNK1G3 promoting cell growth by interacting with miR-181. 1 CircSMARCA5 Regulates VEGFA mRNA Splicing and Angiogenesis in Glioblastoma Multiforme Through the Binding of SRSF1. - hsa_circ_SMARCA5 - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated The circSMARCA5 is an upstream regulator of pro- to anti-angiogenic VEGFA isoforms ratio within GBM cells and a highly promising GBM prognostic and prospective anti-angiogenic molecule. 3 FUS/circ_002136/miR-138-5p/SOX13 feedback loop regulates angiogenesis in Glioma. - - circ_002136 DOID:0060108 brain glioma glioma RT-qPCR up-regulated The feedback loop of FUS/circ_002136/miR-138-5p/SOX13 played a crucial role in the regulation of angiogenesis in glioma. 1 Hsa_circRNA_0054633 is highly expressed in gestational diabetes mellitus and closely related to glycosylation index. hsa_circ_0054633 hsa_circ_PNPT1 circRNA_0054633 DOID:9351 diabetes mellitus gestational diabetes mellitus RT-qPCR up-regulated This study suggests that hsa_cirRNA_0054633 is abnormally expressed in GDM patients and may play a potential role in the development of GDM. The possibility of using circRNAs for the diagnosis of GDM requires additional investigation in future studies. 1 Enhanced expression of circ_0000735 forecasts clinical severity in NSCLC and promotes cell progression via sponging miR-1179 and miR-1182. hsa_circ_0000735 hsa_circ_P2RX1 circ_0000735 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Enhanced expression of circ_0000735 forecasts clinical severity in NSCLC and promotes cell progression via sponging miR-1179 and miR-1182. 4 Upregulated circular RNA circ_0074027 promotes glioblastoma cell growth and invasion by regulating miR-518a-5p/IL17RD signaling pathway. hsa_circ_0074027 hsa_circ_PITX1 circ_0074027 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated The circ_0074027 plays an oncogenic role in GBM by regulating miR-518a-5p/IL17RD signaling. 3 circKIF4A acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer. - hsa_circ_KIF4A - DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated The circKIF4A-miR-375-KIF4A axis regulates TNBC progression via the competitive endogenous RNA (ceRNA) mechanism. circKIF4A may therefore serve as a prognostic biomarker and therapeutic target for TNBC. 2 CircRNA hsa-circ-0014359 promotes glioma progression by regulating miR-153/PI3K signaling. hsa_circ_0014359 hsa_circ_NUP210L hsa-circ-0014359 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "The circ-0014359 promotes glioma progression via targeting miR-153/PI3K signaling pathway. Thus, our study provides insights into glioma progression and reveals potential new targets for treatment of glioma." 1 Hypoxia-elevated circELP3 contributes to bladder cancer progression and cisplatin resistance. - hsa_circ_ELP3 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated We provide the first direct evidence that circular RNA participates in the adaptive response to hypoxia and may play a role in the progression and drug resistance of bladder cancer. 1 High circ_100053 predicts a poor outcome for chronic myeloid leukemia and is involved in imatinib resistance. - - circ_100053 DOID:8552 chronic myeloid leukemia chronic myeloid leukemia RNA-seq up-regulated "High circ_100053 expression predicted a poor outcome of CML patients and imatinib resistance, suggesting the putative role of circ_100053 as an CML biomarker." 1 Hsa_circ_0003998 Promotes Chemoresistance via Modulation of miR-326 in Lung Adenocarcinoma Cells. hsa_circ_0003998 hsa_circ_ARFGEF2 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Inactivation of hsa_circ_0003998 or activation of miR-326 could be a novel approach for the treatment of LAD. 1 Circular RNA hsa_circ_0072309 inhibits proliferation and invasion of breast cancer cells via targeting miR-492. hsa_circ_0072309 hsa_circ_LIFR - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated Our findings revealed for the first time that the hsa_circ_0072309-miR-492 axis plays an essential role in breast cancer progression. 2 A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma. hsa_circ_0005962 hsa_circ_YWHAZ - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated A circRNA signature was identified as a potential noninvasive biomarker for LUAD diagnosis. 1 A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma. hsa_circ_0086414 hsa_circ_BNC2 - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated A circRNA signature was identified as a potential noninvasive biomarker for LUAD diagnosis. 1 CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p. - hsa_circ_PSMC3 circPSMC3 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Our study reveals that circPSMC3 can serve as a novel potential circulating biomarker for detection of GC. CircPSMC3 participates in progression of gastric cancer by sponging miRNA-296-5p with PTEN, providing a new insight into the treatment of gastric cancer." 1 High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients. - - ciRNA-1880_RHOA DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, RNA-seq" down-regulated "The obtained results provide a valuable addition to the published studies on the mechanism of PCOS pathogenesis by revealing a wide variety of new circRNAs, miRNA, and gene targets that merit further investigation." 1 High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients. - - ciRNA-2003_BECN1 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, RNA-seq" down-regulated "The obtained results provide a valuable addition to the published studies on the mechanism of PCOS pathogenesis by revealing a wide variety of new circRNAs, miRNA, and gene targets that merit further investigation." 1 High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients. - - circRNA-6335_MAN1A2 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, RNA-seq" down-regulated "The obtained results provide a valuable addition to the published studies on the mechanism of PCOS pathogenesis by revealing a wide variety of new circRNAs, miRNA, and gene targets that merit further investigation." 1 High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients. - - circRNA-12884_BPTF DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, RNA-seq" down-regulated "The obtained results provide a valuable addition to the published studies on the mechanism of PCOS pathogenesis by revealing a wide variety of new circRNAs, miRNA, and gene targets that merit further investigation." 1 High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients. - - ciRNA-7323_TIAM1 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, RNA-seq" down-regulated "The obtained results provide a valuable addition to the published studies on the mechanism of PCOS pathogenesis by revealing a wide variety of new circRNAs, miRNA, and gene targets that merit further investigation." 1 High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients. - - ciRNA-10775_RUVBL1 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, RNA-seq" down-regulated "The obtained results provide a valuable addition to the published studies on the mechanism of PCOS pathogenesis by revealing a wide variety of new circRNAs, miRNA, and gene targets that merit further investigation." 1 High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients. - - circRNA-9160_CLEC16A DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, RNA-seq" down-regulated "The obtained results provide a valuable addition to the published studies on the mechanism of PCOS pathogenesis by revealing a wide variety of new circRNAs, miRNA, and gene targets that merit further investigation." 1 High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients. - - circRNA-15112_UBAP2 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, RNA-seq" down-regulated "The obtained results provide a valuable addition to the published studies on the mechanism of PCOS pathogenesis by revealing a wide variety of new circRNAs, miRNA, and gene targets that merit further investigation." 1 High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients. - - ciRNA-785_RELA DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, RNA-seq" up-regulated "The obtained results provide a valuable addition to the published studies on the mechanism of PCOS pathogenesis by revealing a wide variety of new circRNAs, miRNA, and gene targets that merit further investigation." 1 High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients. - - circRNA-14867_ASH1L DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, RNA-seq" down-regulated "The obtained results provide a valuable addition to the published studies on the mechanism of PCOS pathogenesis by revealing a wide variety of new circRNAs, miRNA, and gene targets that merit further investigation." 1 CircRNA circ_0067934 Overexpression Correlates with Poor Prognosis and Promotes Thyroid Carcinoma Progression. hsa_circ_0067934 hsa_circ_PRKCI circ_0067934 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated The circ_0067934 could improve the development of thyroid carcinoma by promoting EMT and PI3K/AKT signaling pathways. 2 hsa_circRNA_104597: a novel potential diagnostic and therapeutic biomarker for schizophrenia. - - hsa_circRNA_104597 DOID:5419 schizophrenia schizophrenia RT-qPCR down-regulated Dysregulation of_sa_circRNA_104597_ay serve as a novel potential diagnostic and therapeutic biomarker for SZ. 1 Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression. - hsa_circ_TFRC cTFRC DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated The cTFRC may exert regulatory functions in BC and may be a potential marker of BC diagnosis or progression. 1 Circular RNA hsa_circ_0014243 may serve as a diagnostic biomarker for essential hypertension. hsa_circ_0014243 hsa_circ_CHTOP - DOID:10825 essential hypertension essential hypertension "RT-qPCR, microarray" up-regulated "The present results suggest that hsa_circ_0014243 has a crucial role in the genesis and development of EH, and presents a certain diagnostic capability for EH." 1 circRAPGEF5 Contributes to Papillary Thyroid Proliferation and Metastatis by Regulation miR-198/FGFR1. hsa_circ_0001681 hsa_circ_RAPGEF5 circRAPGEF5 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "The circRAPGEF5 acts as a tumor promoter via a novel circRAPGEF5/miR-198/FGFR1 axis, providing a potential biomarker and therapeutic target for the management of PTC." 1 Circular RNA expression in exosomes derived from breast cancer cells and patients. hsa_circ_0009634 hsa_circ_ENO1 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated We identified a number of dysregulated circRNAs in exosomes from BCa cells and patients. 1 Circular RNA expression in exosomes derived from breast cancer cells and patients. hsa_circ_0020707 hsa_circ_RPLP2 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated We identified a number of dysregulated circRNAs in exosomes from BCa cells and patients. 1 Circular RNA expression in exosomes derived from breast cancer cells and patients. hsa_circ_0064923 hsa_circ_RPL14 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated We identified a number of dysregulated circRNAs in exosomes from BCa cells and patients. 1 Circular RNA expression in exosomes derived from breast cancer cells and patients. hsa_circ_0104852 hsa_circ_RHCG - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated We identified a number of dysregulated circRNAs in exosomes from BCa cells and patients. 1 Circular RNA expression in exosomes derived from breast cancer cells and patients. hsa_circ_0087064 hsa_circ_GRHPR - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated We identified a number of dysregulated circRNAs in exosomes from BCa cells and patients. 1 circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis. - hsa_circ_TADA2As - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated "The circTADA2As as promising prognostic biomarkers in TNBC patients, and therapeutic targeting of circTADA2As/miRNA/mRNA network may be a potential strategy for the treatment of breast cancer." 1 RNA-Seq profiling of circular RNAs and potential function of hsa_circ_0002360 in human lung adenocarcinom. hsa_circ_0002360 hsa_circ_RUNX1 - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated "The hsa_circ_0002360 was aberrantly and abundantly expressed and implicated in the development of LAC, suggesting a valuable therapeutic target for LAC treatment." 2 CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth. - hsa_circ_SETD3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated "CircSETD3 is a novel tumour suppressor of HCC and is a valuable prognostic biomarker. Moreover, circSETD3 inhibits the growth of HCC partly through the circSETD3/miR-421/MAPK14 pathway." 1 Circular RNA circBACH2 plays a role in papillary thyroid carcinoma by sponging miR-139-5p and regulating LMO4 expression. - hsa_circ_BACH2 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "The circBACH2 acts as a novel oncogenic RNA that sponges miR-139-5p and can be used as a tumor biomarker of PTC. Whats more, these results revealed that the circBACH2/miR-139-5p/LMO4 axis could be targeted as a potential treatment strategy for PTC." 1 circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:3770 pulmonary fibrosis pulmonary fibrosis RT-qPCR up-regulated "We revealed that circHIPK3 is upregulated in bleomycin-induced pulmonary fibrosis mice model, FMT-derived myofibroblasts. circHIPK3 silencing can ameliorate FMT and suppress fibroblast proliferation in vivo and vitro. Fundamentally, circHIPK3 regulates FMT by functioning as an endogenous miR-338-3p sponge and inhibit miR-338-3p activity, thereby leading to increased SOX4 and COL1A1 expression. Moreover, dysregulated circHIPK3 expression was detected in the clinical samples of patients with idiopathic pulmonary fibrosis." 1 Circular RNA circVAPA is up-regulated and exerts oncogenic properties by sponging miR-101 in colorectal cancer. - hsa_circ_VAPA - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "The circVAPA is up-regulated in CRC patients tissues and plasma, and exerts oncogenic properties by sponging miR-101 in CRC." 3 Circular RNA hsa_circ_0000885 Levels are Increased in Tissue and Serum Samples from Patients with Osteosarcoma. hsa_circ_0000885 hsa_circ_INSR - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated Hsa_circ_0000885 was upregulated in serum of osteosarcoma patients and could serve as a good diagnostic biomarker for osteosarcoma. 2 CircHMGCS1 Promotes Hepatoblastoma Cell Proliferation by Regulating the IGF Signaling Pathway and Glutaminolysis. - hsa_circ_HMGCS1 - DOID:687 hepatoblastoma hepatoblastoma "RT-qPCR, RNA-seq" up-regulated "The circHMGCS1/miR-503-5p/IGF-PI3K-Akt axis regulates the proliferation, apoptosis and glutaminolysis of HB cells, implying that circHMGCS1 is a promising therapeutic target and prognostic marker for HB patients." 1 Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets. hsa_circ_0001944 hsa_circ_FIRRE - DOID:1612 breast cancer breast cancer brain metastasis "RT-qPCR, RNA-seq" up-regulated "The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002." 1 Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets. hsa_circ_0001481 hsa_circ_EMB - DOID:1612 breast cancer breast cancer brain metastasis "RT-qPCR, RNA-seq" up-regulated "The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002." 1 Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets. hsa_circ_0000646 hsa_circ_HDGFRP3 - DOID:1612 breast cancer breast cancer brain metastasis "RT-qPCR, RNA-seq" up-regulated "The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002." 1 Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets. hsa_circ_0001006 hsa_circ_RTN4 - DOID:1612 breast cancer breast cancer brain metastasis "RT-qPCR, RNA-seq" up-regulated "The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002." 2 Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets. hsa_circ_0000732 hsa_circ_SCARF1 - DOID:1612 breast cancer breast cancer brain metastasis "RT-qPCR, RNA-seq" up-regulated "The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002." 2 Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets. hsa_circ_0001910 hsa_circ_WWC3 - DOID:1612 breast cancer breast cancer brain metastasis "RT-qPCR, RNA-seq" down-regulated "The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002." 2 Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets. hsa_circ_0008285 hsa_circ_CDYL - DOID:1612 breast cancer breast cancer brain metastasis "RT-qPCR, RNA-seq" down-regulated "The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002." 2 Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets. hsa_circ_0000002 hsa_circ_SDF4 - DOID:1612 breast cancer breast cancer brain metastasis "RT-qPCR, RNA-seq" down-regulated "The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002." 1 Expression profile of circular RNAs in placentas of women with gestational diabetes mellitus. hsa_circ_0005243 hsa_circ_TMEM184B - DOID:9351 diabetes mellitus gestational diabetes mellitus "RT-qPCR, RNA-seq" down-regulated "qRT-PCR verified that the expression of circ_5824, circ_3636, and circ_0395 was consistent with RNA-seq analysis; their expression levels were significantly lower in the GDM group than in the control group. The circRNA-miRNA interaction was analyzed according to the molecular sponge mechanism, and its potential function is discussed. These results shed light on future functional studies of circRNAs related to GDM." 2 Expression profile of circular RNAs in placentas of women with gestational diabetes mellitus. - - circ_3636 DOID:9351 diabetes mellitus gestational diabetes mellitus "RT-qPCR, RNA-seq" down-regulated "qRT-PCR verified that the expression of circ_5824, circ_3636, and circ_0396 was consistent with RNA-seq analysis; their expression levels were significantly lower in the GDM group than in the control group. The circRNA-miRNA interaction was analyzed according to the molecular sponge mechanism, and its potential function is discussed. These results shed light on future functional studies of circRNAs related to GDM." 1 Expression profile of circular RNAs in placentas of women with gestational diabetes mellitus. - - circ_0395 DOID:9351 diabetes mellitus gestational diabetes mellitus "RT-qPCR, RNA-seq" down-regulated "qRT-PCR verified that the expression of circ_5824, circ_3636, and circ_0397 was consistent with RNA-seq analysis; their expression levels were significantly lower in the GDM group than in the control group. The circRNA-miRNA interaction was analyzed according to the molecular sponge mechanism, and its potential function is discussed. These results shed light on future functional studies of circRNAs related to GDM." 1 circRNA_CER mediates malignant progression of breast cancer through targeting the miR_136/MMP13 axis. - hsa_circ_CER - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "The present results suggested that circRNA_CER may serve an important role in the progression of breast cancer by regulating the activity of the miR_136/MMP13 axis, and may be a potential biomarker for the prediction and treatment of breast cancer." 1 Reconstruction and analysis of circRNA_miRNA_mRNA network in the pathology of cervical cancer. - - hsa_circRNA_000596 DOID:4362 cervical cancer cervical cancer microarray dysregulated "The 5 circRNAs (hsa_circRNA_000596, hsa_circRNA_104315, hsa_circRNA_400068, hsa_circRNA_101958 and hsa_circRNA_103519) may function as competing endogenous RNAs and serve critical roles in cervical cancer." 1 Reconstruction and analysis of circRNA_miRNA_mRNA network in the pathology of cervical cancer. - - hsa_circRNA_104315 DOID:4362 cervical cancer cervical cancer microarray dysregulated "The 5 circRNAs (hsa_circRNA_000596, hsa_circRNA_104315, hsa_circRNA_400068, hsa_circRNA_101958 and hsa_circRNA_103519) may function as competing endogenous RNAs and serve critical roles in cervical cancer." 1 Reconstruction and analysis of circRNA_miRNA_mRNA network in the pathology of cervical cancer. - - hsa_circRNA_400068 DOID:4362 cervical cancer cervical cancer microarray dysregulated "The 5 circRNAs (hsa_circRNA_000596, hsa_circRNA_104315, hsa_circRNA_400068, hsa_circRNA_101958 and hsa_circRNA_103519) may function as competing endogenous RNAs and serve critical roles in cervical cancer." 1 Reconstruction and analysis of circRNA_miRNA_mRNA network in the pathology of cervical cancer. - - hsa_circRNA_101958 DOID:4362 cervical cancer cervical cancer microarray dysregulated "The 5 circRNAs (hsa_circRNA_000596, hsa_circRNA_104315, hsa_circRNA_400068, hsa_circRNA_101958 and hsa_circRNA_103519) may function as competing endogenous RNAs and serve critical roles in cervical cancer." 1 Reconstruction and analysis of circRNA_miRNA_mRNA network in the pathology of cervical cancer. - - hsa_circRNA_103519 DOID:4362 cervical cancer cervical cancer microarray dysregulated "The 5 circRNAs (hsa_circRNA_000596, hsa_circRNA_104315, hsa_circRNA_400068, hsa_circRNA_101958 and hsa_circRNA_103519) may function as competing endogenous RNAs and serve critical roles in cervical cancer." 1 circ-Sirt1 controls NF-kappaB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells. - hsa_circ_SIRT1 circ-Sirt1 DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated The circ-Sirt1 is a novel non-coding RNA regulator of VSMC phenotype. 1 "The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition." - hsa_circ_ZC3H4 - DOID:10325 silicosis silicosis RT-qPCR up-regulated "ZC3H4 may act as a novel regulator in the progression of SiO2-induced EMT, which provides a reference for further pulmonary fibrosis research." 2 Identification of Key circRNAs/lncRNAs/miRNAs/mRNAs and Pathways in Preeclampsia Using Bioinformatics Analysis. hsa_circ_0088196 hsa_circ_TNC - DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated "miR-100-5p may suppress PE development, while LIF, LINC01492, and hsa_circ_0088196 may promote it though inhibiting miR-100-5p. The jak-stat signaling pathway was activated and involved in PE progression." 2 Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation. - - chr9:15474007-15490122 DOID:0060224 atrial fibrillation atrial fibrillation RNA-seq dysregulated "The study to uncover the association between circRNAs and AF, which not only improves our understanding of the roles of circRNAs in AF, but also provides candidates of potentially functional circRNAs for AF researchers." 1 Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation. - - chr16:75445723-75448593 DOID:0060224 atrial fibrillation atrial fibrillation RNA-seq dysregulated "The study to uncover the association between circRNAs and AF, which not only improves our understanding of the roles of circRNAs in AF, but also provides candidates of potentially functional circRNAs for AF researchers." 1 Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation. hsa_circ_0007256 hsa_circ_CSGALNACT2 - DOID:0060224 atrial fibrillation atrial fibrillation RNA-seq dysregulated "The study to uncover the association between circRNAs and AF, which not only improves our understanding of the roles of circRNAs in AF, but also provides candidates of potentially functional circRNAs for AF researchers." 1 Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation. - - chr12:56563313-56563992 DOID:0060224 atrial fibrillation atrial fibrillation RNA-seq dysregulated "The study to uncover the association between circRNAs and AF, which not only improves our understanding of the roles of circRNAs in AF, but also provides candidates of potentially functional circRNAs for AF researchers." 1 Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation. hsa_circ_0003533 hsa_circ_ANO10 - DOID:0060224 atrial fibrillation atrial fibrillation RNA-seq dysregulated "The study to uncover the association between circRNAs and AF, which not only improves our understanding of the roles of circRNAs in AF, but also provides candidates of potentially functional circRNAs for AF researchers." 1 Circular RNA circ_0002138 is down-regulated and suppresses cell proliferation in colorectal cancer. hsa_circ_0002138 hsa_circ_USP3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated The circ_0002138 may become a novel potential biomarker for diagnosis and treatment target of CRC. 2 CircRNA has_circ_0001946 promotes cell growth in lung adenocarcinoma by regulating miR-135a-5p/SIRT1 axis and activating Wnt/beta-catenin signaling pathway. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" up-regulated The circ_0001946 might be a potential biomarker for the diagnosis or treatment of LAC. 2 Aberrant expression of serum circANRIL and hsa_circ_0123996 in children with Kawasaki disease. hsa_circ_0123996 hsa_circ_FBXW12 - DOID:13378 Kawasaki disease kawasaki disease RT-qPCR up-regulated Our study indicated that the circANRIL and hsa_circ_0123996 levels in the serum of patients with KD were significantly different from those in healthy individuals. circANRIL and hsa_circ_0123996 may become potential biomarkers for early KD diagnosis. 1 "CircRNA_104916 regulates migration, apoptosis and epithelial-mesenchymal transition in colon cancer cells." - - circRNA_104916 DOID:219 colon cancer colon cancer RT-qPCR down-regulated The circRNA_104916 is a potential biomarker and therapeutic target for colorectal cancers. 1 Elevation of circular RNA circ_0003645 forecasts unfavorable prognosis and facilitates cell progression via miR-1179/TMEM14A pathway in non-small cell lung cancer. hsa_circ_0003645 hsa_circ_C16orf62 circ_0003645 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated This study indicates that circ_0003645 might possess crucial potential as a prognosis predictor and therapeutic target for NSCLC patients. 1 Upregulation of circular RNA circ-ERBB2 predicts unfavorable prognosis and facilitates the progression of gastric cancer via miR-503/CACUL1 and miR-637/MMP-19 signaling. - hsa_circ_ERBB2 circ-ERBB2 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated The circ-ERBB2 functions as an oncogene in GC and might be useful in developing promising therapies for this fatal malignancy. 2 Circular RNA hsa_circ_0001368 suppresses the progression of gastric cancer by regulating miR-6506-5p/FOXO3 axis. hsa_circ_0001368 hsa_circ_KLHL24 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated The hsa_circ_0001368 plays a tumor-suppression role in GC via the miR-6506-5p/FOXO3 axis and may serve as a potential target for GC therapy. 1 Circular RNA hsa_circ_0055538 regulates the malignant biological behavior of oral squamous cell carcinoma through the p53/Bcl-2/caspase signaling pathway. hsa_circ_0055538 hsa_circ_RMND5A - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated Our results indicated that hsa_circ_0055538 is involved in OSCC via the p53 signaling pathway and may be a diagnostic and/or prognostic marker as well as a therapeutic target. 1 Up-regulation of circular RNA hsa_circ_0037909 promotes essential hypertension. hsa_circ_0037911 hsa_circ_GSPT1 - DOID:10825 essential hypertension essential hypertension RT-qPCR up-regulated The combination of hsa_circ_0037911 and hsa-miR-637 may be a significant important biomarker for early diagnosis of EH. 2 Circular RNA circHIPK3 promotes cell proliferation and invasion of prostate cancer by sponging miR-193a-3p and regulating MCL1 expression. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "The circHIPK3-mediated miR-193a-3p-MCL1 signaling promotes PCa development and progression, providing a novel therapeutic target for PCa." 4 Downregulation of circDYNC1H1 exhibits inhibitor effect on cell proliferation and migration in hepatocellular carcinoma through miR-140-5p. - hsa_circ_DYNC1H1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Downregulation of circDYNC1H1 exhibits inhibitor effect on cell proliferation and migration in hepatocellular carcinoma through miR-140-5p. 1 CircRNA_0044073 is upregulated in atherosclerosis and increases the proliferation and invasion of cells by targeting miR_107. hsa_circ_0044073 hsa_circ_GRN CircRNA-0044073 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "circRNA_0044073 is upregulated in atherosclerosis and promotes the proliferation and invasion of cells by targeting miR_107 and activating the JAK/STAT signaling pathway, potentially offering a target for novel treatment strategies against atherosclerosis." 3 Down-regulation of circular RNA ITCH and circHIPK3 in gastric cancer tissues. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Cir_ITCH and circHIPK3 may have imperative roles in GC and serve in the future as potential prognostic biomarkers in GC. 3 Down-regulation of circular RNA ITCH and circHIPK3 in gastric cancer tissues. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Cir_ITCH and circHIPK3 may have imperative roles in GC and serve in the future as potential prognostic biomarkers in GC. 6 circLPAR1 is a novel biomarker of prognosis for muscle-invasive bladder cancer with invasion and metastasis by miR-762. hsa_circ_0087960 hsa_circ_LPAR1 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated The circLPAR1 may function as a potential novel and stable biomarker for the prognosis of MIBC and may be associated with the invasion and metastasis by miR-762. 1 RNA-seq of circular RNAs identified circPTPN22 as a potential new activity indicator in systemic lupus erythematosus. - hsa_circ_PTPN22 circPTPN22 DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, RNA-seq" down-regulated Our data demonstrated the aberrant expression of circRNAs in patients with SLE compared with healthy controls; circPTPN22 might function as a diagnostic and disease severity indicator in SLE. 1 "A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f." hsa_circ_0043278 hsa_circ_TADA2A - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f." 6 Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b. - hsa_circ_TTC3 circ-Ttc3 DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b. 1 "Upregulated circ RNA hsa_circ_0000337 promotes cell proliferation, migration, and invasion of esophageal squamous cell carcinoma." hsa_circ_0000337 hsa_circ_PPFIA1 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "The hsa_circ_0000337 was found to be an upregulated circRNA that is related to ESCC and promotes the progression of disease by regulating cell proliferation, migration, and invasion." 2 Inhibition of circular RNA CDR1as increases chemosensitivity of 5-FU-resistant BC cells through up-regulating miR-7. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:1612 breast cancer breast cancer RT-qPCR up-regulated CDR1as may regulate chemosensitivity of 5-FU-resistant BC cells by inhibiting miR-7 to regulate CCNE1. 2 Circular HDAC9/microRNA-138/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer Disease. - hsa_circ_HDAC9 - DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR down-regulated "The circHDAC9/miR-138/Sirt1 pathway mediates synaptic function and APP processing in AD, providing a potential therapeutic target for its treatment." 1 circEPSTI1 regulates ovarian cancer progression via decoying miR-942. - hsa_circ_EPSTI1 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated The circEPSTI1 regulated EPSTI1 expression and ovarian cancer progression by sponging miR-942. circEPSTI1 could be used as a biomarker and therapeutic target in ovarian cancer. 1 Altered expression profile of circular RNAs in conjunctival melanoma. hsa_circ_0083444 hsa_circ_MTUS1 - DOID:1751 malignant conjunctival melanoma conjunctival melanoma RNA-seq up-regulated CircMTUS1 may serve as an oncogene by binding to hsa-miR-622 and hsa-miR-1208 to regulate several tumor-related pathways. 1 Circular RNA expression alterations in colon tissues of Crohn disease patients. - - hsa_circRNA_102685 DOID:8778 Crohn disease Crohn disease microarray up-regulated "The hsa_circRNA_102685, was involved in certain important signalling pathways of CD, and may be novel targets for diagnosis or treatment in this disease." 1 circEIF4G2 modulates the malignant features of cervical cancer via the miR_218/HOXA1 pathway. - hsa_circ_EIF4G2 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated The present findings suggested that circEIF4G2 promoted cell proliferation and migration via the miR_218/HOXA1 pathway. 1 Circular RNA ciRS-7 promotes the proliferation and metastasis of pancreatic cancer by regulating miR-7-mediated EGFR/STAT3 signaling pathway. - - RNA ciRS-7 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "Circular RNA ciRS-7 plays an oncogene role in PDAC, partly by targeting miR-7 and regulating the EGFR/STAT3 signaling pathway." 1 Circular RNA 0039411 Is Involved in Neodymium Oxide-induced Inflammation and Antiproliferation in a Human Bronchial Epithelial Cell Line via Sponging miR-93-5p hsa_circ_0039411 - - DOID:0050117 disease by infectious agent inflammation and antiproliferation RT-qPCR up-regulated These results suggested that upregulation of circ_0039411 mediated Nd2O3-induced inflammation and dysfunction by sponging miR-93-5p 1 Decreased expression of hsa_circ_0072387 as a valuable predictor for oral squamous cell carcinoma. hsa_circ_0072387 hsa_circ_HMGCS1 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated Our finding suggested that lower expression of has_circ_0072387 could be a key circRNA in OSCC and serve as a potential biomarker in OSCC diagnosis and therapeutic targets. 2 CircRNA-012091/PPP1R13B-mediated Lung Fibrotic Response in Silicosis via Endoplasmic Reticulum Stress and Autophagy. - - circRNA-012091 DOID:850 lung disease pulmonary fibrosis in silicosis RT-qPCR up-regulated "These results suggest that PPP1R13B regulated by circ-012091 promotes the proliferation and migration of lung fibroblasts through ERS and autophagy, and plays a crucial role in the development of pulmonary fibrosis in silicosis." 1 Circ0001429 regulates progression of bladder cancer through binding miR-205-5p and promoting VEGFA expression. hsa_circ_0001429 hsa_circ_MANBA circ0001429 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "Circ0001429 and VEGFA were highly expressed in bladder cancer, while miR-205-5p were lowly expressed in bladder cancer. The circ0001429 could target at miR-205-5p to regulate VEGFA and promote the development of bladder cancer." 1 Reduction of circular RNA expression associated with human retinoblastoma. hsa_circ_0093996 hsa_circ_TET1 - DOID:768 retinoblastoma retinoblastoma RNA-seq down-regulated "CircRNA expression is downregulated in RB tumor, which suggests epigenetic regulation of RB pathogenesis by circRNAs." 2 Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4. hsa_circ_0004339 hsa_circ_DONSON circ-DONSON DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated The circ-DONSON promotes GC progression through recruiting the NURF complex to initiate SOX4 expression. 3 Circular RNA PVT1 promotes metastasis via miR-145 sponging in CRC. - hsa_circ_PVT1 circPVT1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circPVT1, working as an oncogene, promotes metastasis via miR-145 sponging in CRC." 2 Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression. - hsa_circ_LAMP1 - DOID:5603 T-cell acute lymphoblastic leukemia t-cell lymphoblastic lymphoma RT-qPCR up-regulated Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression. 1 CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene. - hsa_circ_SERPINE2 - DOID:8398 osteoarthritis osteoarthritis RNA-seq down-regulated Our results reveal an important role for a novel circRNA-CircSERPINE2 in OA progression. CircSERPINE2 overexpression could alleviate HCs apoptosis and promote anabolism of ECM through miR-1271-ERG pathway. 2 "Role of the ciRS-7/miR-7 axis in the regulation of proliferation, apoptosis and inflammation of chondrocytes induced by IL-1beta." hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "The ciRS-7/miR-7 axis can possibly serve as a regulator in mediating proliferation, apoptosis and inflammation in chondrocytes in the process of OA development." 2 A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling. - hsa_circ_PPP1R12A circPPP1R12A DOID:219 colon cancer colon cancer "RT-qPCR, RNA-seq" up-regulated "In the present study, we illustrated the coding-potential of circRNA circPPP1R12A in the progression of CC. Moreover, we identified that circPPP1R12A-73aa promoted the tumor pathogenesis and metastasis of CC via activating Hippo-YAP signaling pathway." 1 Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression. - hsa_circ_AKT3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression. 4 CircRNA_000543 knockdown sensitizes nasopharyngeal carcinoma to irradiation by targeting miR-9/platelet-derived growth factor receptor B axis. - - circRNA_000543 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated CircRNA_000543 knockdown sensitizes nasopharyngeal carcinoma to irradiation by targeting miR-9/platelet-derived growth factor receptor B axis. 1 "circ-BIRC6, a circular RNA, promotes hepatocellular carcinoma progression by targeting the miR-3918/Bcl2 axis." - hsa_circ_BIRC6 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated circ-BIRC6 functions as a competing endogenous RNA that regulates Bcl2 expression by sponging miR-3918. 2 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0001577 hsa_circ_RANBP9 - DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RNA-seq up-regulated Several circRNAs were differentially expressed in women of reproductive age with PCOS. 2 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0020093 hsa_circ_ATRNL1 - DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RNA-seq down-regulated Several circRNAs were differentially expressed in women of reproductive age with PCOS. 1 Upregulation of circular RNA circ_0034642 indicates unfavorable prognosis in glioma and facilitates cell proliferation and invasion via the miR-1205/BATF3 axis. - - circ_0034642 DOID:0060108 brain glioma glioma RT-qPCR up-regulated Upregulation of circular RNA circ_0034642 indicates unfavorable prognosis in glioma and facilitates cell proliferation and invasion via the miR-1205/BATF3 axis. 1 Circular RNA CEP128 promotes bladder cancer progression by regulating Mir-145-5p/Myd88 via MAPK signaling pathway. - hsa_circ_CEP128 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated Overexpression of circCEP128 promoted bladder cancer progression through modulating miR-145-5p and MYD88 via MAKP signaling pathway. 2 Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression. - hsa_circ_TADA2A - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated CircTADA2A functions as a tumor promoter in OS to increase malignant tumor behavior through the miR-203a-3p/CREB3 axis. 2 Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome. hsa_circ_0043533 hsa_circ_TOP2A - DOID:11612 polycystic ovary syndrome polycystic ovary syndrome microarray up-regulated The expression of circRNAs in CCs was significantly different between PCOS and normal control individuals. 2 Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome. hsa_circ_0097636 hsa_circ_KNTC1 - DOID:11612 polycystic ovary syndrome polycystic ovary syndrome microarray down-regulated The expression of circRNAs in CCs was significantly different between PCOS and normal control individuals. 1 Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome. hsa_circ_0043532 hsa_circ_TOP2A - DOID:11612 polycystic ovary syndrome polycystic ovary syndrome microarray up-regulated The expression of circRNAs in CCs was significantly different between PCOS and normal control individuals. 2 Hsa_circ_0001742 promotes tongue squamous cell carcinoma progression via modulating miR-634 expression. hsa_circ_0001742 hsa_circ_SMO - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma RT-qPCR up-regulated hsa_circ_0001742 could promote TSCC progression by targeting miR-634/RAB1A pathway. 4 "Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis." hsa_circ_0051240 hsa_circ_CEACAM5 - DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, microarray" up-regulated "Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis." 1 Elevation of circular RNA circ_0005230 facilitates cell growth and metastasis via sponging miR-1238 and miR-1299 in cholangiocarcinoma. hsa_circ_0005230 hsa_circ_DNM3OS circ_0005230 DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR up-regulated circular RNA circ_0005230 facilitates cell growth and metastasis via sponging miR-1238 and miR-1299 in cholangiocarcinoma. 2 Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice. - mmu_circ_NFIX - DOID:114 heart disease cardiac regeneration RT-qPCR down-regulated Loss of superenhancer-regulated circNfix promotes cardiac regenerative repair and functional recovery after myocardial infarction by suppressing Ybx1 ubiquitin-dependent degradation and increasing miR-214 activity. 1 Identification of Key Genes and Circular RNAs in Human Gastric Cancer. hsa_circ_0000332 hsa_circ_PC - DOID:10534 stomach cancer gastric cancer microarray down-regulated "Key candidate genes and circRNAs were identified, and novel PPI and circRNA-microRNA-mRNA networks in GC were constructed." 1 Identification of Key Genes and Circular RNAs in Human Gastric Cancer. hsa_circ_0021087 hsa_circ_LMO1 - DOID:10534 stomach cancer gastric cancer microarray down-regulated "Key candidate genes and circRNAs were identified, and novel PPI and circRNA-microRNA-mRNA networks in GC were constructed." 3 CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling. - hsa_circ_DLST - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircDLST promotes the tumorigenesis and metastasis of GC cells by sponging miR-502-5p to activate the NRAS/MEK1/ERK1/2 signaling. 2 Circular RNA circ-FOXM1 facilitates cell progression as ceRNA to target PPDPF and MACC1 by sponging miR-1304-5p in non-small cell lung cancer. - hsa_circ_FOXM1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ-FOXM1/miR-1304-5p/PPDPF/MACC1 signaling was essential for the development and progression of NSCLC. 4 Circular RNA GATAD2A promotes H1N1 replication through inhibiting autophagy. - hsa_circ_GATAD2A - DOID:934 viral infectious disease influenza A virus infection RT-qPCR up-regulated circ-GATAD2A promotes the replication of H1N1 by inhibiting autophagy. 1 circSMARCA5 Functions as a Diagnostic and Prognostic Biomarker for Gastric Cancer. - hsa_circ_SMARCA5 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Our results demonstrated that circSMARCA5 was decreased and exerted tumor-suppressive effects in GC. 2 FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E-cadherin and CD44 expression. - hsa_circ_FNDC3B - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circFNDC3B promotes the migration and invasion of gastric cancer cells via the regulation of E-cadherin and CD44 expression. 4 "circ-CSPP1 promotes proliferation, invasion and migration of ovarian cancer cells by acting as a miR-1236-3p sponge." - hsa_circ_CSPP1 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "our findings suggest that by acting as a miR-1236-3p sponge, circ-CSPP1 impairs the inhibitory effect of miR-1236-3p on ZEB1, which subsequently promotes EMT and OC development." 1 Upregulated circular RNA circ_0070934 facilitates cutaneous squamous cell carcinoma cell growth and invasion by sponging miR-1238 and miR-1247-5p. hsa_circ_0070934 hsa_circ_LARP1B - DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma RT-qPCR up-regulated Upregulated circular RNA circ_0070934 facilitates cutaneous squamous cell carcinoma cell growth and invasion by sponging miR-1238 and miR-1247-5p. 5 Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:114 heart disease cardiac fibrosis "RT-qPCR, RNA-seq" dysregulated "Our data suggest that circHIPK3 serves as a miR-29b-3p sponge to regulate CF proliferation, migration and development of cardiac fibrosis." 4 CircCDYL inhibits the expression of C-MYC to suppress cell growth and migration in bladder cancer. - hsa_circ_CDYL - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated Our findings suggest that circCDYL functions as a tumor suppressor in bladder cancer by down-regulating the expression of C-MYC. 1 Circular RNA circ_0026134 regulates non-small cell lung cancer cell proliferation and invasion via sponging miR-1256 and miR-1287. hsa_circ_0026134 hsa_circ_TUBA1C - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circular RNA circ_0026134 regulates non-small cell lung cancer cell proliferation and invasion via sponging miR-1256 and miR-1287. 3 "Circular RNA hsa_circ_0002024 suppresses cell proliferation, migration, and invasion in bladder cancer by sponging miR-197-3p." hsa_circ_0002024 hsa_circ_NAB1 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "our data demonstrated that hsa_circ_0002024 suppresses cell proliferation, migration, and invasion in BC by sponging miR-197-3p." 1 A regulatory circuit of circ-MTO1/miR-17/QKI-5 inhibits the proliferation of lung adenocarcinoma. hsa_circ_0007874 hsa_circ_MTO1 - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated our data suggest that circ-MTO1 is a critical negative regulator of LUAD and elucidate the potential molecular mechanism of a novel circ-MTO1/miR-17/QKI-5 feedback loop in inhibiting LUAD progression. 1 Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway. hsa_circ_0004771 hsa_circ_NRIP1 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated Hsa_circ_0004771/miR-653/ZEB2 regulatory feedback revealed a new molecular mechanism in the pathogenesis of breast cancer. 2 Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa-miR-132-3p/Sox5 signalling pathway. - hsa_circ_DOCK1 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated circDOCK1 affected the progression of BC via modulation of circDOCK1/hsa-miR-132-3p/Sox5 pathway both in vitro and in vivo and providing a potential biomarker and therapeutic targets for BC. 2 Low Expression of hsa_circ_0018069 in Human Bladder Cancer and Its Clinical Significance. hsa_circ_0018069 hsa_circ_KIAA1462 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated hsa_circ_0018069 may thus play an important role in the occurrence and progression of bladder cancer. 1 CircLMTK2 acts as a novel tumor suppressor in gastric cancer. - hsa_circ_LMTK2 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated circLMTK2 was down-regulated in GC. 2 Hsa_circ_0004370 promotes esophageal cancer progression through miR-1294/LASP1 pathway. hsa_circ_0004370 hsa_circ_PRRX1 - DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "The results present here suggest that hsa_circ_0004370 functions as an oncogene on cell proliferation, apoptosis, and invasion via miR-1294/LASP1 axis." 1 Identification of Altered Circular RNA Expression in Serum Exosomes from Patients with Papillary Thyroid Carcinoma by High-Throughput Sequencing. - - hsacirc_007293 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, RNA-seq" up-regulated "The findings from this study have shown that gene regulation can be studied from exosomes obtained from serum samples in patients with papillary thyroid carcinoma, and supports the need for further studies on the role of exosome circRNAs in thyroid cancer." 1 Identification of Altered Circular RNA Expression in Serum Exosomes from Patients with Papillary Thyroid Carcinoma by High-Throughput Sequencing. - - hsacirc_031752 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, RNA-seq" up-regulated "The findings from this study have shown that gene regulation can be studied from exosomes obtained from serum samples in patients with papillary thyroid carcinoma, and supports the need for further studies on the role of exosome circRNAs in thyroid cancer." 1 Identification of Altered Circular RNA Expression in Serum Exosomes from Patients with Papillary Thyroid Carcinoma by High-Throughput Sequencing. - - hsacirc_020135 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, RNA-seq" down-regulated "The findings from this study have shown that gene regulation can be studied from exosomes obtained from serum samples in patients with papillary thyroid carcinoma, and supports the need for further studies on the role of exosome circRNAs in thyroid cancer." 1 Hypoxia-associated circDENND2A promotes glioma aggressiveness by sponging miR-625-5p. - hsa_circ_DENND2A - DOID:0060108 brain glioma glioma RT-qPCR up-regulated circDENND2A is required for the hypoxia-induced malignancy of glioma cells and functions by sponging miR-625-5p. 1 CircRASSF2 promotes laryngeal squamous cell carcinoma progression by regulating the miR-302b-3p/IGF-1R axis. - hsa_circ_RASSF2 circRASSF2 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma microarray up-regulated these data suggest that circRASSF2 is a central component linking circRNAs to progression of LSCC via an miR-302b-3p/IGF-1R axis. 1 Upregulation of hsa_circ_0136666 contributes to breast cancer progression by sponging miR-1299 and targeting CDK6. hsa_circ_0136666 hsa_circ_PRKDC - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Upregulation of hsa_circ_0136666 promoted breast cancer progression by sponging miR-1299 and targeting CDK6. 1 Circular RNA hsa_circ_0068871 regulates FGFR3 expression and activates STAT3 by targeting miR-181a-5p to promote bladder cancer progression. hsa_circ_0068871 hsa_circ_FGFR3 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Hsa_circ_0068871 regulates the miR-181a-5p/FGFR3 axis and activates STAT3 to promote BCa progression, and it may serve as a potential biomarker." 1 A novel circular RNA circ-ZNF652 promotes hepatocellular carcinoma metastasis through inducing snail-mediated epithelial-mesenchymal transition by sponging miR-203/miR-502-5p. - hsa_circ_ZNF652 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated our findings suggest that circ-ZNF652 is a novel driver of EMT and unveil the important regulatory role of circ-ZNF652/miR-203/miR-502-5p/Snail feedback loop in HCC metastasis. 2 circRAD18 sponges miR-208a/3164 to promote triple-negative breast cancer progression through regulating IGF1 and FGF2 expression. - hsa_circ_RAD18 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated our research revealed the pivotal role of circRAD18-miR-208a/3164-IGF1/FGF2 axis in TNBC tumorigenesis and metastasis though the mechanism of competing endogenous RNAs. 1 CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p. - hsa_circ_ZNF609 circ-ZNF609 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "Highly expressed circ-ZNF609 adsorbs microRNA-150-5p to upregulate Sp1 expression, thereby promoting the proliferation and metastatic ability of NPC cells." 5 Circular RNA MAT2B Promotes Glycolysis and Malignancy of Hepatocellular Carcinoma Through the miR-338-3p/PKM2 Axis Under Hypoxic Stress. - hsa_circ_MAT2B - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circMAT2B promoted HCC progression by enhanced glycolysis by activating the circMAT2B/miR-338-3p/PKM2 axis under hypoxia, which may provide a therapeutic target for HCC." 1 The circRNA circP4HB promotes NSCLC aggressiveness and metastasis by sponging miR-133a-5p. - hsa_circ_P4HB circP4HB DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circP4HB enhances EMT and metastatic disease through miR-133a-5p sequestration, leading to upregulation of vimentin." 2 Circular RNA cMras inhibits lung adenocarcinoma progression via modulating miR-567/PTPRG regulatory pathway. - hsa_circ_Mras cMras DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "A novel circular RNA cMras and its functions were identified, discovering a cMras/miR-567/PTPRG regulatory pathway in LUAD tumorigenesis and development." 1 Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer. - - circRNA1656 DOID:7320 ovarian serous cystadenofibroma high-grade serous ovarian cancer "RT-qPCR, RNA-seq" down-regulated Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer. 1 "Circular RNA circ_001350 regulates glioma cell proliferation, apoptosis, and metastatic properties by acting as a miRNA sponge." - - circ_001350 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circ_001350 directly sponges miR-1236, thus contributing to malignant progression of glioma." 1 Identification of differentially expressed circular RNAs in chemoresistant colorectal cancer. - - hsa_circ_32883 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated Hsa circ 32883 and hsa circ 0338 are upregulated in CRC tissue. 1 Identification of differentially expressed circular RNAs in chemoresistant colorectal cancer. - - hsa_circ_0338 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated Hsa circ 32883 and hsa circ 0338 are upregulated in CRC tissue. 1 Circular RNA expression profile in gingival tissues identifies circ_0062491 and circ_0095812 as potential treatment targets. hsa_circ_0062491 hsa_circ_MIR650 circ_0062491 DOID:824 periodontitis periodontitis "RT-qPCR, RNA-seq" down-regulated Circ_0062491 was identified as the sponge of miR-584 which play a key role in periodontitis. 2 Circular RNA expression profile in gingival tissues identifies circ_0062491 and circ_0095812 as potential treatment targets. hsa_circ_0095812 hsa_circ_LRRC4C circ_0095812 DOID:824 periodontitis periodontitis "RT-qPCR, RNA-seq" up-regulated Circ_0062491 was identified as the sponge of miR-584 which play a key role in periodontitis. 1 Downregulated circular RNA hsa_circ_0067301 regulates epithelial-mesenchymal transition in endometriosis via the miR-141/Notch signaling pathway. hsa_circ_0067301 hsa_circ_PLXND1 - DOID:288 endometriosis of uterus endometriosis RT-qPCR down-regulated Results demonstrate the hsa_circ_0067301/miR-141-5p/Notch-1 axis plays an important regulatory role in the process of EMT in endometriosis. 1 Comprehensive circular RNA expression profiles and the tumor-suppressive function of circHIPK3 in ovarian cancer. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated circHIPK3 is an important regulator of ovarian cancer progression. 1 Translation of the circular RNA circbeta-catenin promotes liver cancer cell growth through activation of the Wnt pathway. - - circbeta-catenin DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq up-regulated circular RNA circbeta-catenin promotes liver cancer cell growth through activation of the Wnt pathway. 1 "Knockdown of cZNF292 suppressed hypoxic human hepatoma SMMC7721 cell proliferation, vasculogenic mimicry, and radioresistance." - hsa_circ_ZNF292 cZNF292 DOID:684 hepatocellular carcinoma hepatoma RT-qPCR dysregulated A novel mechanism of cZNF292 in enhancing hypoxic tumor cell radiosensitivity. 2 Circ-ATP8A2 promotes cell proliferation and invasion as a ceRNA to target EGFR by sponging miR-433 in cervical cancer. - hsa_circ_ATP8A2 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Circ-ATP8A2 promotes cell proliferation and invasion as a ceRNA to target EGFR by sponging miR-433 in cervical cancer. 1 Hsa_circ_0005379 regulates malignant behavior of oral squamous cell carcinoma through the EGFR pathway. hsa_circ_0005379 hsa_circ_GDI2 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated Hsa_circ_0005379 regulates malignant behavior of oral squamous cell carcinoma through the EGFR pathway. 2 Differential expression and bioinformatics analysis of circRNA in osteosarcoma. - - circ_32279 DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated The present study identified a profile of abnormal regulation of circRNA in osteosarcoma. 1 Differential expression and bioinformatics analysis of circRNA in osteosarcoma. - - circ_24831 DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated The present study identified a profile of abnormal regulation of circRNA in osteosarcoma. 1 Differential expression and bioinformatics analysis of circRNA in osteosarcoma. - - circ_2137 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated The present study identified a profile of abnormal regulation of circRNA in osteosarcoma. 1 Differential expression and bioinformatics analysis of circRNA in osteosarcoma. - - circ_20403 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated The present study identified a profile of abnormal regulation of circRNA in osteosarcoma. 1 Integrated analysis of circRNAs and mRNAs expression profile revealed the involvement of hsa_circ_0007919 in the pathogenesis of ulcerative colitis. hsa_circ_0007919 - - DOID:8577 ulcerative colitis ulcerative colitis "RT-qPCR, microarray" down-regulated "Hsa_circ_0007919 was reduced persistently after inflammatory treatments, and it was relevant to Mayo endoscopic subscores and the expression of tight junction molecules. Finally, hsa_circ_0007919 could harbor miR-138, and let-7a to regulate the targeted mRNAs EPC1 and VIPR1." 1 "Overexpression of circ_0005198 sponges miR-1294 to regulate cell proliferation, apoptosis, migration, and invasion in glioma." hsa_circ_0005198 hsa_circ_PARP4 circ_0005198 DOID:0060108 brain glioma glioma RT-qPCR up-regulated circ_0005198 could directly sponge miR-1294 to exert oncogenic functions. 2 circMAN1A2 could serve as a novel serum biomarker for malignant tumors. - hsa_circ_MAN1A2 - DOID:162 cancer malignant cancer RT-qPCR up-regulated circMAN1A2 could be a serum biomarker for malignant tumors. 1 Circular RNA circCHFR Facilitates the Proliferation and Migration of Vascular Smooth Muscle via miR-370/FOXO1/Cyclin D1 Pathway. - hsa_circ_CHFR - DOID:1936 atherosclerosis atherosclerosis "RT-qPCR, microarray" up-regulated this finding states the vital role of the circCHFR/miR-370/FOXO1/Cyclin D1 axis. 6 CircPRKCI-miR-545/589-E2F7 axis dysregulation mediates hydrogen peroxide-induced neuronal cell injury. hsa_circ_0067934 hsa_circ_PRKCI - DOID:231 motor neuron disease neuronal cell injury RT-qPCR down-regulated dysregulation of circPRKCI-miR-545/589-E2F7 axis mediated H(2)O(2)-induced neuronal cell injury. Targeting this novel cascade could be a fine strategy to protect neurons from oxidative stress. 1 Circ_0005075 promotes hepatocellular carcinoma progression by suppression of microRNA-335. hsa_circ_0005075 hsa_circ_EIF4G3 circ_0005075 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Our data provide evidence that circ_0005705 promotes the HCC progression by sponging miR-335 and further regulating MAPK1 expression. 4 Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration. hsa_circ_0054652 hsa_circ_EFEMP1 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" up-regulated These results revealed that circRNAs may play a role in IDD and might be a promising candidate molecular target for gene therapy. 4 Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration. hsa_circ_0054657 hsa_circ_EFEMP1 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" up-regulated These results revealed that circRNAs may play a role in IDD and might be a promising candidate molecular target for gene therapy. 4 Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration. hsa_circ_0054659 hsa_circ_EFEMP1 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" up-regulated These results revealed that circRNAs may play a role in IDD and might be a promising candidate molecular target for gene therapy. 4 Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration. hsa_circ_0025367 hsa_circ_MFAP5 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" up-regulated These results revealed that circRNAs may play a role in IDD and might be a promising candidate molecular target for gene therapy. 1 Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration. hsa_circ_0054660 hsa_circ_EFEMP1 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" up-regulated These results revealed that circRNAs may play a role in IDD and might be a promising candidate molecular target for gene therapy. 4 Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration. hsa_circ_0008932 hsa_circ_LRP6 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" up-regulated These results revealed that circRNAs may play a role in IDD and might be a promising candidate molecular target for gene therapy. 1 Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration. hsa_circ_0092222 hsa_circ_RPS4Y1 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated These results revealed that circRNAs may play a role in IDD and might be a promising candidate molecular target for gene therapy. 2 Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration. hsa_circ_0092221 hsa_circ_RPS4Y1 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated These results revealed that circRNAs may play a role in IDD and might be a promising candidate molecular target for gene therapy. 2 Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration. hsa_circ_0088732 hsa_circ_LCN2 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated These results revealed that circRNAs may play a role in IDD and might be a promising candidate molecular target for gene therapy. 1 Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration. hsa_circ_0069234 hsa_circ_FGFBP1 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated These results revealed that circRNAs may play a role in IDD and might be a promising candidate molecular target for gene therapy. 1 Circular RNA circ_0103552 forecasts dismal prognosis and promotes breast cancer cell proliferation and invasion by sponging miR-1236. hsa_circ_0103552 hsa_circ_UBR1 circ_0103552 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circular RNA circ_0103552 forecasts dismal prognosis and promotes breast cancer cell proliferation and invasion by sponging miR-1236. 3 Comprehensive circular RNA profiling reveals circ_0002060 as a potential diagnostic biomarkers for osteoporosis. hsa_circ_0002060 hsa_circ_DYNC1H1 circ_0002060 DOID:11476 osteoporosis osteoporosis RT-qPCR up-regulated ROC analysis indicated that circ_0002060 showed potential diagnostic value for osteoporosis. 1 Dysregulated circRNA_100876 suppresses proliferation of osteosarcoma cancer cells by targeting microRNA-136. - - circRNA_100876 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "the dysregulation of circRNA_100876 could induce apoptosis and arrest the cell cycle at G2/M stage, followed by suppression of cell proliferation in osteosarcoma, while silencing miR-136 could restore the cell growth." 1 Elevation of circ-PITX1 upregulates interleukin 17 receptor D expression via sponging miR-518a-5p and facilitates cell progression in glioma. - hsa_circ_PITX1 circ-PITX1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated Elevation of circ-PITX1 upregulates interleukin 17 receptor D expression via sponging miR-518a-5p and facilitates cell progression in glioma. 2 Circular RNA hsa_circ_0075828 promotes bladder cancer cell proliferation through activation of CREB1. hsa_circ_0075828 hsa_circ_LINC00340 - DOID:11054 urinary bladder cancer bladder cancer microarray up-regulated "circCASC15 promotes cell proliferation in BC, which might be a new molecular target for BC diagnosis and therapy." 1 "Circular RNA rno_circ_0004002 regulates cell proliferation, apoptosis, and epithelial-mesenchymal transition through targeting miR-342-5p and Wnt3a in anorectal malformations." - - rno_circ_0004002 DOID:1285 rectal disease anorectal malformation RT-qPCR up-regulated "our study shed light on the regulatory mechanism of rno_circ_0004002 in cell proliferation, apoptosis, and EMT via sponging miR-342-5p, which downregulated the Wnt3a expression in anorectal development." 1 Identification of circular RNA-associated competing endogenous RNA network in the development of cleft palate. - - circRNA_0954 DOID:674 cleft palate cleft palate "RT-qPCR, RNA-seq" up-regulated The present results imply that circRNA_0954-miRNA-881-3p-PRKAR1alpha ceRNA network may cause dysfunctional palatal fusion and might facilitate the development of novel epigenetic biomarkers to treat CP in the future. 1 Up-regulated circular RNA VANGL1 contributes to progression of non-small cell lung cancer through inhibition of miR-195 and activation of Bcl-2. - hsa_circ_VANGL1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated we conclude that circVANGL1 functions as an oncogene to promote NSCLC progression partly through miR-195/Bcl-2 axis. 1 Hsa_circ_0005075 predicts a poor prognosis and acts as an oncogene in colorectal cancer via activating Wnt/beta-catenin pathway. hsa_circ_0005075 hsa_circ_EIF4G3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Cellular studies indicated that circ_0005075 can enhance the proliferation, migration, and invasion capacities of CRC cells, thereby promoting tumor progression." 2 Enhanced expression of circular RNA hsa_circ_000984 promotes cells proliferation and metastasis in non-small cell lung cancer by modulating Wnt/beta-catenin pathway. - - hsa_circ_000984 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Enhanced expression of circular RNA hsa_circ_000984 promotes cells proliferation and metastasis in non-small cell lung cancer by modulating Wnt/beta-catenin pathway. 1 Up-regulated circular RNA hsa_circ_0067934 contributes to glioblastoma progression through activating PI3K-AKT pathway. hsa_circ_0067934 hsa_circ_PRKCI - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "Hsa_circ_0067934 is overexpressed and plays an oncogenic role in GBM by promoting cancer cell proliferation and metastasis via upregulation of PI3K-AKT pathway, which suggests that hsa_circ_0067934 is likely to serve as an efficient therapeutic approach in respect of GBM treatment." 1 Hsa_circ_0002577 promotes endometrial carcinoma progression via regulating miR-197/CTNND1 axis and activating Wnt/beta-catenin pathway. hsa_circ_0002577 hsa_circ_WDR26 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated we indicated that hsa_circ_0002577 could play critical functions by hsa_circ_0002577/miR-197/CTNND1/Wnt/beta-catenin signaling pathway. 4 Hsa_circ_0023404 enhances cervical cancer metastasis and chemoresistance through VEGFA and autophagy signaling by sponging miR-5047. hsa_circ_0023404 hsa_circ_RNF121 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated we reveal a novel role of hsa_circ_0023404 for cervical cancer metastasis and chemoresistance by regulating miR-5047. 3 Role and mechanism of circ-PRKCI in hepatocellular carcinoma. - hsa_circ_PRKCI circPRKCI DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "This study explores the role and mechanism of circ-PRKCI in HCC, which provides a new research direction and theoretical basis for the treatment of HCC." 1 "circLRP6 regulates high glucose-induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells." - mmu_circ_LRP6 - DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "these data suggest that circLRP6 regulates HG-induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells via sponging miR-205, upregulating HMGB1 and activating TLR4/NF-kappaB pathway." 1 Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622. hsa_circ_0101432 hsa_circ_RPPH1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Hsa_circ_0101432 inhibited HCC cell apoptosis, promoted cell proliferation, invasive ability and HCC tumor growth by targeting miR-1258 and miR-622 and upregulating MAPK1 mRNA expression." 6 Decreased expression of circ_0020397 in intracranial aneurysms may be contributing to decreased vascular smooth muscle cell proliferation via increased expression of miR-138 and subsequent decreased KDR expression. hsa_circ_0020397 hsa_circ_DOCK1 - DOID:10941 intracranial aneurysm intracranial aneurysm RT-qPCR down-regulated decreased expression of circRNA_0020397 in IA may contribute to the decreased VSMC proliferation via increasing miR-138 expression and subsequently decreasing KDR expression. 1 Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis. - hsa_circ_ACVR2A - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated circACVR2A functions as a tumor suppressor to inhibit bladder cancer cell proliferation and metastasis through miR-626/EYA4 axis. 1 Circ_ORC2 enhances the regulatory effect of miR-19a on its target gene PTEN to affect osteosarcoma cell growth. - hsa_circ_ORC2 circORC2 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circ_ORC2 binds with miR-19a and enhances its expression, thereby inhibiting downstream PTEN expression and activating Akt pathway to promote osteosarcoma cell growth and invasion." 1 Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease. hsa_circ_0001879 hsa_circ_NIPSNAP3A - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, RNA-seq" up-regulated "The combination of hsa_circ_0001879 and hsa_circ_0004104, together with CAD risk factors, had the better performance to discriminate CAD patients from healthy controls. Overexpression of hsa_circ_0004104 resulted in dysregulation of atherosclerosis-related genes in THP-1-derived macrophages." 1 Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease. hsa_circ_0004104 hsa_circ_SPARC - DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, RNA-seq" up-regulated "The combination of hsa_circ_0001879 and hsa_circ_0004104, together with CAD risk factors, had the better performance to discriminate CAD patients from healthy controls. Overexpression of hsa_circ_0004104 resulted in dysregulation of atherosclerosis-related genes in THP-1-derived macrophages." 2 Hsa_circ_001569 is an unfavorable prognostic factor and promotes cell proliferation and metastasis by modulating PI3K-AKT pathway in breast cancer. - - hsa_circ_001569 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "hsa_circ_001569 upregulation was associated with BC lymph-node metastasis, clinical stage, and poor prognosis. Hsa_circ_001569 might contribute to progression of BC by modulating PI3K-AKT pathway." 1 A novel circular RNA hsa_circ_0008035 contributes to gastric cancer tumorigenesis through targeting the miR-375/YBX1 axis. hsa_circ_0008035 hsa_circ_EXT1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "hsa_circ_0008035 acted as a sponge for the miR-375 and absorbed its expression, and miR-375 was found to target YBX1 3-UTR, constructing a hsa_circ_0008035/miR-375/YBX1 axis." 4 Circular RNA ABCB10 promotes tumor progression and correlates with pejorative prognosis in clear cell renal cell carcinoma. - hsa_circ_ABCB10 - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated Circ-ABCB10 promotes tumor progression and correlates with pejorative prognosis in ccRCC. 1 Downregulation of hsa_circ_0068087 ameliorates TLR4/NF-kappaB/NLRP3 inflammasome-mediated inflammation and endothelial cell dysfunction in high glucose conditioned by sponging miR-197. hsa_circ_0068087 hsa_circ_GNB4 - DOID:4195 hyperglycemia hyperglycemia RT-qPCR up-regulated these results suggest that downregulation of hsa_circ_0068087 ameliorates TLR4/NF-¦ĘB/NLRP3 inflammasome-mediated inflammation and endothelial cell dysfunction in the high glucose condition by sponging miR-197. 1 Circular RNA circHIAT1 inhibits cell growth in hepatocellular carcinoma by regulating miR-3171/PTEN axis. - hsa_circ_HIAT1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Both in vitro and in vivo experiments demonstrated the suppressive effect of circHIAT1 on the HCC cell growth. Mechanistically, circHIAT1 acted as the miR-3171 sponge to upregulate PTEN in HCC." 1 Microarray Profiling of Circular RNA Identifies hsa_circ_0126991 as a Potential Risk Factor for Essential Hypertension. hsa_circ_0126991 hsa_circ_SEPT11 - DOID:10825 essential hypertension essential hypertension "RT-qPCR, RNA-seq" up-regulated the present study uncovered a novel perspective that hyperexpression of hsa_circ_0126991 is correlated with the risk of EH and may serve as a stable biomarker for early diagnosis of EH. 1 [Cyclic RNA Molecule circ_0007766 Promotes the Proliferation of Lung Adenocarcinoma Cells by Up-regulating the Expression of Cyclin D1/CyclinE1/CDK4]. hsa_circ_0007766 hsa_circ_ERBB2 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "In vitro functional studies have shown that circ_0007766 may promote the proliferation and migration of lung adenocarcinoma cells. Further molecular mechanism studies have found that circ_0007766 can up-regulate the expression of Cyclin D1/Cyclin E1/CDK4, which are the key proteins of cell cycle, and thus promote the malignant proliferation of lung adenocarcinoma." 2 Hsa_circ_0009361 acts as the sponge of miR-582 to suppress colorectal cancer progression by regulating APC2 expression. hsa_circ_0009361 hsa_circ_GNB1 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" down-regulated "Hsa_circ_0009361 acted as a tumor suppressive sponge of miR-582, which could up-regulate the expression of APC2, inhibit the Wnt/beta-catenin signaling, and suppress the growth and metastasis of CRC." 1 Circular RNA expression profile of knee condyle in osteoarthritis by illumina HiSeq platform. hsa_circ_0045714 hsa_circ_UNK - DOID:8398 osteoarthritis osteoarthritis RNA-seq dysregulated OA-related circRNAs. 4 Circular RNA expression profile of knee condyle in osteoarthritis by illumina HiSeq platform. hsa_circ_0002485 hsa_circ_ATP9B - DOID:8398 osteoarthritis osteoarthritis RNA-seq dysregulated OA-related circRNAs. 1 Circular RNA expression profile of knee condyle in osteoarthritis by illumina HiSeq platform. hsa_circ_0005567 hsa_circ_EPS15 - DOID:8398 osteoarthritis osteoarthritis RNA-seq dysregulated OA-related circRNAs. 2 Matrine induces apoptosis and autophagy of glioma cell line U251 by regulation of circRNA-104075/BCL-9. - - circ-104075 DOID:0060108 brain glioma glioma RT-qPCR dysregulated the present findings suggested that matrine induced apoptosis and autophagy through down-regulating circ-104075 and Bcl-9 expression via inhibition of PI3K/AKT and Wnt-beta-catenin pathways in glioma cells. 1 Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy. - mmu_circ_Slc8a1 - DOID:114 heart disease cardiac hypertrophy RT-qPCR up-regulated "In summary, circSlc8a1 can function as an endogenous sponge for miR-133a in cardiomyocytes. We propose that circSlc8a1 may serve as a novel therapeutic target for cardiac hypertrophy." 1 Circ-ZNF264 Promotes the Growth of Glioma Cells by Upregulating the Expression of miR-4493 Target Gene Apelin. - hsa_circ_ZNF264 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "In glioma cells, circ-ZNF264 can inhibit the function of miR-4493 and then upregulate its target gene apelin expression, thus regulating glioma cell proliferation, apoptosis, and invasion." 1 Circular RNA 0001785 regulates the pathogenesis of osteosarcoma as a ceRNA by sponging miR-1200 to upregulate HOXB2. hsa_circ_0001785 hsa_circ_ELP3 circ-0001785 DOID:3347 osteosarcoma osteosarcoma microarray up-regulated circ-0001785 regulates the pathogenesis of osteosarcoma by sponging miR-1200 to up-regulate HOXB2 expression. 1 Circular RNA F-circSR derived from SLC34A2-ROS1 fusion gene promotes cell migration in non-small cell lung cancer. - - F-circSR1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "identified two novel circRNAs (F-circSR1 and F-circSR2) generated from SLC34A2-ROS1 fusion gene, while F-circSR1 has higher expression than F-circSR2." 1 Circular RNA F-circSR derived from SLC34A2-ROS1 fusion gene promotes cell migration in non-small cell lung cancer. - - F-circSR2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "identified two novel circRNAs (F-circSR1 and F-circSR2) generated from SLC34A2-ROS1 fusion gene, while F-circSR1 has higher expression than F-circSR2." 1 CircHIPK3 overexpression accelerates the proliferation and invasion of prostate cancer cells through regulating miRNA-338-3p. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated Overexpression of circHIPK3 promotes the proliferative and invasive potentials of PCa cells through sponging miRNA-338-3p to regulate ADAM17 expression. 4 A circular RNA derived from COL6A3 functions as a ceRNA in gastric cancer development. - hsa_circ_COL6A3 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "the present study indicated that overexpressed circCOL6A3 promoted cell proliferation, migration and apoptosis of gastric cancer through rescission of miR-3064-5p-induced inhibitory effect on COL6A3." 3 "Knockdown of hsa_circ_0023028 inhibits cell proliferation, migration, and invasion in laryngeal cancer by sponging miR-194-5p." hsa_circ_0023028 hsa_circ_C11orf80 - DOID:2600 laryngeal carcinoma laryngeal cancer RT-qPCR up-regulated "hsa_circ_0023028 functions as an miR-194-5p sponge to promote the proliferation, migration, and invasion of LCa cells." 1 Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus. - hsa_circ_E7 - DOID:11166 human papillomavirus infectious disease human papillomaviruses RT-qPCR up-regulated "virus-derived, protein-encoding circular RNAs are biologically functional and linked to the transforming properties of some HPV." 1 Circular RNA-100219 promotes breast cancer progression by binding to microRNA-485-3p. - - RNA-100219 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Overexpression of circ-10021 promotes the proliferative and migratory capacities of breast cancer cells by sponging microRNA-485-3p to upregulate the NTRK3 expression. 1 Circular RNA circMAN2B2 facilitates glioma progression by regulating the miR-1205/S100A8 axis. - hsa_circ_MAN2B2 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circMAN2B2 could improve cell proliferation, invasion, and migration of the glioma by inhibiting miR-1205 and promoting the expression of S100A8." 1 Circular RNA Cdr1as sensitizes bladder cancer to cisplatin by upregulating APAF1 expression through miR-1270 inhibition. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:11054 urinary bladder cancer bladder cancer RT-qPCR dysregulated Cdr1as exerts a cisplatin-chemosensitization effect on bladder cancer cells through the Cdr1as/miR-1270/APAF1 axis. 2 Circular RNA profiling of neutrophil transcriptome provides insights into asymptomatic Moyamoya disease. - - hsa_circRNA_100146 DOID:13099 Moyamoya disease moyamoya "RT-qPCR, microarray" up-regulated "Five circRNAs (hsa_circRNA_100146, hsa_circRNA_102534, hsa_circRNA_036592, hsa_circRNA_405463 and hsa_circRNA_405324) were chosen and their expression levels were analysed by qRT-PCR in ten MMD and matched control blood samples." 1 Circular RNA profiling of neutrophil transcriptome provides insights into asymptomatic Moyamoya disease. - - hsa_circRNA_102534 DOID:13099 Moyamoya disease moyamoya "RT-qPCR, microarray" down-regulated "Five circRNAs (hsa_circRNA_100146, hsa_circRNA_102534, hsa_circRNA_036592, hsa_circRNA_405463 and hsa_circRNA_405324) were chosen and their expression levels were analysed by qRT-PCR in ten MMD and matched control blood samples." 1 Circular RNA profiling of neutrophil transcriptome provides insights into asymptomatic Moyamoya disease. - - hsa_circRNA_036592 DOID:13099 Moyamoya disease moyamoya "RT-qPCR, microarray" up-regulated "Five circRNAs (hsa_circRNA_100146, hsa_circRNA_102534, hsa_circRNA_036592, hsa_circRNA_405463 and hsa_circRNA_405324) were chosen and their expression levels were analysed by qRT-PCR in ten MMD and matched control blood samples." 1 Circular RNA profiling of neutrophil transcriptome provides insights into asymptomatic Moyamoya disease. - - hsa_circRNA_405463 DOID:13099 Moyamoya disease moyamoya "RT-qPCR, microarray" up-regulated "Five circRNAs (hsa_circRNA_100146, hsa_circRNA_102534, hsa_circRNA_036592, hsa_circRNA_405463 and hsa_circRNA_405324) were chosen and their expression levels were analysed by qRT-PCR in ten MMD and matched control blood samples." 1 Circular RNA profiling of neutrophil transcriptome provides insights into asymptomatic Moyamoya disease. - - hsa_circRNA_405324 DOID:13099 Moyamoya disease moyamoya "RT-qPCR, microarray" down-regulated "Five circRNAs (hsa_circRNA_100146, hsa_circRNA_102534, hsa_circRNA_036592, hsa_circRNA_405463 and hsa_circRNA_405324) were chosen and their expression levels were analysed by qRT-PCR in ten MMD and matched control blood samples." 1 Circular RNA hsa_circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge. hsa_circ_0001649 hsa_circ_SHPRH - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated our study showed that circ-0001649 was lowly expressed in HCC and inhibited HCC progression via multiple miRNAs sponge. 4 [Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells]. - - hsa_circRNA_074595 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated The expression profile of circRNA in HER-2 positive breast cancer cells is significantly different from that in normal mammary epithelial cells. 1 [Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells]. - - hsa_circRNA_085362 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated The expression profile of circRNA in HER-2 positive breast cancer cells is significantly different from that in normal mammary epithelial cells. 1 [Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells]. - - hsa_circRNA_074598 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated The expression profile of circRNA in HER-2 positive breast cancer cells is significantly different from that in normal mammary epithelial cells. 1 [Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells]. - - hsa_circRNA_101379 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated The expression profile of circRNA in HER-2 positive breast cancer cells is significantly different from that in normal mammary epithelial cells. 1 [Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells]. - - hsa_circRNA_406683 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated The expression profile of circRNA in HER-2 positive breast cancer cells is significantly different from that in normal mammary epithelial cells. 1 [Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells]. - - hsa_circRNA_021714 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated The expression profile of circRNA in HER-2 positive breast cancer cells is significantly different from that in normal mammary epithelial cells. 1 [Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells]. - - hsa_circRNA_100777 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated The expression profile of circRNA in HER-2 positive breast cancer cells is significantly different from that in normal mammary epithelial cells. 1 [Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells]. - - hsa_circRNA_100796 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated The expression profile of circRNA in HER-2 positive breast cancer cells is significantly different from that in normal mammary epithelial cells. 1 Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis. hsa_circ_0003380 hsa_circ_ZFPM2 - DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, RNA-seq" up-regulated "Our data suggested that circRNAs are differentially expressed in endometriosis, which might be candidate factors for pathogenesis of this disease and be considered as promising therapeutic targets in the future." 1 Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis. hsa_circ_0020093 hsa_circ_ATRNL1 - DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, RNA-seq" up-regulated "Our data suggested that circRNAs are differentially expressed in endometriosis, which might be candidate factors for pathogenesis of this disease and be considered as promising therapeutic targets in the future." 1 Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis. hsa_circ_0002198 hsa_circ_PDE7B - DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, RNA-seq" up-regulated "Our data suggested that circRNAs are differentially expressed in endometriosis, which might be candidate factors for pathogenesis of this disease and be considered as promising therapeutic targets in the future." 3 Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis. hsa_circ_0008016 hsa_circ_FGFR1 - DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, RNA-seq" up-regulated "Our data suggested that circRNAs are differentially expressed in endometriosis, which might be candidate factors for pathogenesis of this disease and be considered as promising therapeutic targets in the future." 1 Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis. hsa_circ_0077837 hsa_circ_EPB41L2 - DOID:11432 endometriosis of ovary ovarian endometriosis "RT-qPCR, RNA-seq" up-regulated "Our data suggested that circRNAs are differentially expressed in endometriosis, which might be candidate factors for pathogenesis of this disease and be considered as promising therapeutic targets in the future." 1 circZFR promotes cell proliferation and migration by regulating miR-511/AKT1 axis in hepatocellular carcinoma. - hsa_circ_ZFR - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circZFR promotes HCC progression by directly down-regulating miR-511 to activate AKT1 signaling, suggesting that circZFR is a potential target in HCC treatment." 4 A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma. - hsa_circ_CDYL - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma. 1 Circular RNA circ_0079593 indicates a poor prognosis and facilitates cell growth and invasion by sponging miR-182 and miR-433 in glioma. hsa_circ_0079593 hsa_circ_IGF2BP3 circ_0079593 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "microRNA 182 (miR-182) and miR-433 could be sponged and negatively regulated by circ_0079593. Further, rescue assays demonstrated that the biological functions of circ_0079593 are dependent on its inhibition of miR-182 and miR-433." 3 Hsa_circ_0005519 increases IL-13/IL-6 by regulating hsa-let-7a-5p in CD4(+) T cells to affect asthma. hsa_circ_0005519 hsa_circ_SNX13 - DOID:2841 asthma asthma microarray up-regulated hsa_circ_0005519 may induce IL-13 and IL-6 expression by regulating hsa-let-7a-5p in CD4+ T cells to affect asthma. 1 CircMTO1 inhibits liver fibrosis via regulation of miR-17-5p and Smad7. - hsa_circ_MTO1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated we demonstrate that circMTO1 inhibits liver fibrosis via regulation of miR-17-5p and Smad7. 3 Downregulation of circ_0132266 in chronic lymphocytic leukemia promoted cell viability through miR-337-3p/PML axis. hsa_circ_0132266 hsa_circ_MTO1 circ_0132266 DOID:1040 chronic lymphocytic leukemia chronic lymphocytic leukemia RT-qPCR down-regulated indicated the regulatory mechanism of circ_0132266 in CLL progression through circ_0132266/miR-337-3p/PML axis. 1 Circular RNA circTRIM33-12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression. - hsa_circ_TRIM33-12 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "These results reveal the important role of circTRIM33-12 in the proliferation, migration, invasion and immune evasion abilities of HCC cells and provide a new perspective on circRNAs in HCC progression." 1 Circular RNA circ_0020123 promotes non-small cell lung cancer progression by acting as a ceRNA for miR-488-3p to regulate ADAM9 expression. - - circ_0020123 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circular RNA circ_0020123 promotes non-small cell lung cancer progression by acting as a ceRNA for miR-488-3p to regulate ADAM9 expression. 2 circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer. hsa_circ_0025202 hsa_circ_GAPDH circRNA_0025202 DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "hsa_circ_0025202 served an anti-oncogenic role in HR-positive breast cancer, and it could be exploited as a novel marker for tamoxifen-resistant breast cancer." 2 Circular RNA circ KMT2E is up-regulated in diabetic cataract lenses and is associated with miR-204-5p sponge function. - hsa_circ_KMT2E - DOID:13328 diabetic cataract diabetic cataract "RT-qPCR, RNA-seq" up-regulated we speculated that circKMT2E may function as a sponge molecule of miR-204-5p and play a role in the pathogenesis of DC. 1 CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress. - hsa_circ_ACC1 - DOID:3350 mesenchymal cell neoplasm metabolic stress RT-qPCR up-regulated We conclude that circACC1 serves as an economic means to elicit AMPK activation and moreover propose that cancer cells exploit circACC1 during metabolic reprogramming. 1 CircRNA-100338 Is Associated With mTOR Signaling Pathway and Poor Prognosis in Hepatocellular Carcinoma. - - circRNA-100338 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq up-regulated elevated circRNA-100338 activates mTOR signaling pathway in HCC via circRNA-100338/miR-141-3p/RHEB axis and associates with poor prognosis of hepatitis B-related HCC patients. 2 "Circular RNA 0047905 acts as a sponge for microRNA4516 and microRNA1227-5p, initiating gastric cancer progression." hsa_circ_0047905 hsa_circ_SERPINB5 circRNA0047905 DOID:10534 stomach cancer gastric cancer microarray up-regulated We investigated the possibility that circular RNA 0047905 (circRNA0047905) might act as a tumor promoter in the pathogenesis of gastric cancer by profiling miRNA expression in GC tissues and paired noncancerous mucosa tissues using miRNA microarrays. 2 The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p. - hsa_circ_PTPRA circPTPRA DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" down-regulated "circPTPRA suppresses EMT and metastasis of NSCLC cell lines by sponging miR-96-5p, which upregulates the downstream tumor suppressor RASSF8. The circPTPRA/miR-96-5p/RASSF8/E-cadherin axis can be leveraged as a potential treatment avenue in NSCLC." 1 Analysis of ceRNA network identifies prognostic circRNA biomarkers in bladder cancer. hsa_circ_0076704 hsa_circ_CD2AP - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated hsa_circ_0076704 is independent prognostic factor for bladder cancer. 2 Analysis of ceRNA network identifies prognostic circRNA biomarkers in bladder cancer. hsa_circ_0076704 hsa_circ_CD2AP - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "hsa_circ_0076704, hsa_circ_0081963 and hsa_circ_0001361 are potential circRNA related to OS in bladder cancer and expressed in bladder cancer." 2 Analysis of ceRNA network identifies prognostic circRNA biomarkers in bladder cancer. hsa_circ_0081963 hsa_circ_IMMP2L - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "hsa_circ_0076704, hsa_circ_0081963 and hsa_circ_0001362 are potential circRNA related to OS in bladder cancer and expressed in bladder cancer." 1 Analysis of ceRNA network identifies prognostic circRNA biomarkers in bladder cancer. hsa_circ_0001361 hsa_circ_FNDC3B - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "hsa_circ_0076704, hsa_circ_0081963 and hsa_circ_0001363 are potential circRNA related to OS in bladder cancer and expressed in bladder cancer." 2 Expression profiles of circular RNAs in human colorectal cancer based on RNA deep sequencing. hsa_circ_0142527 hsa_circ_PREX2 - DOID:9256 colorectal cancer colorectal cancer RNA-seq down-regulated The circRNA expression profile of CRC provided new clues for understanding the occurrence of CRC. Hsa_circ_0142527 may be served as a potential biomarker for the diagnosis of CRC. 2 Circular RNAs as Potential Blood Biomarkers in Amyotrophic Lateral Sclerosis. hsa_circ_0023919 hsa_circ_PICALM - DOID:332 amyotrophic lateral sclerosis amyotrophic lateral sclerosis microarray down-regulated "expression of 7/10 circRNAs was significant in a larger cohort of ALS patients, compared with age- and sex-matched healthy controls. Three of them (hsa_circ_0023919, hsa_circ_0063411, and hsa_circ_0088036) showed the same regulation as in microarray results." 1 Circular RNAs as Potential Blood Biomarkers in Amyotrophic Lateral Sclerosis. hsa_circ_0063411 hsa_circ_TNRC6B - DOID:332 amyotrophic lateral sclerosis amyotrophic lateral sclerosis microarray up-regulated "expression of 7/10 circRNAs was significant in a larger cohort of ALS patients, compared with age- and sex-matched healthy controls. Three of them (hsa_circ_0023919, hsa_circ_0063411, and hsa_circ_0088036) showed the same regulation as in microarray results." 1 Circular RNAs as Potential Blood Biomarkers in Amyotrophic Lateral Sclerosis. hsa_circ_0088036 hsa_circ_SUSD1 - DOID:332 amyotrophic lateral sclerosis amyotrophic lateral sclerosis microarray up-regulated "expression of 7/10 circRNAs was significant in a larger cohort of ALS patients, compared with age- and sex-matched healthy controls. Three of them (hsa_circ_0023919, hsa_circ_0063411, and hsa_circ_0088036) showed the same regulation as in microarray results." 1 CircPCMTD1 Acts as the Sponge of miR-224-5p to Promote Glioma Progression. - hsa_circ_PCMTD1 circPCMTD1 DOID:0060108 brain glioma glioma microarray up-regulated "circPCMTD1 could contribute to the promotion of glioma progression, and it may serve as the sponge of miR-224-5p to exert its function." 1 Circular RNA CircCACTIN Promotes Gastric Cancer Progression by Sponging MiR-331-3p and Regulating TGFBR1 Expression. - hsa_circ_CACTIN - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated "The circCACTIN/miR-331-3p/TGFBR1 axis affected the proliferation, migration, invasion and EMT of GC through the mechanism of competing endogenous RNAs (ceRNA)." 1 Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes. - hsa_circ_ANKRD12 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated "Our study demonstrates the functional relevance of circANKRD12 in various cancer cell types and, based on its expression pattern, has the potential to become a new clinical biomarker." 3 Circular RNA ATXN7 is upregulated in non-small cell lung cancer and promotes disease progression. - hsa_circ_ATXN7 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated the present study was the first to identify that circATXN7 was upregulated in NSCLC tumor tissues. 1 Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms. hsa_circ_0003227 hsa_circ_NUP155 - DOID:1612 breast cancer breast cancer microarray dysregulated "We combined several systems, biology tools and approaches to identify influential BC circRNAs, miRNAs, and related mRNAs as the members of competing endogenous RNAs (ceRNAs) networks and related RNA binding proteins (RBPs) to study and decipher the BC-triggering biological processes and pathways." 1 Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms. hsa_circ_0001955 hsa_circ_CSNK1G1 - DOID:1612 breast cancer breast cancer microarray dysregulated "We combined several systems, biology tools and approaches to identify influential BC circRNAs, miRNAs, and related mRNAs as the members of competing endogenous RNAs (ceRNAs) networks and related RNA binding proteins (RBPs) to study and decipher the BC-triggering biological processes and pathways." 2 Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms. hsa_circ_0020080 hsa_circ_FAM160B1 - DOID:1612 breast cancer breast cancer microarray dysregulated "We combined several systems, biology tools and approaches to identify influential BC circRNAs, miRNAs, and related mRNAs as the members of competing endogenous RNAs (ceRNAs) networks and related RNA binding proteins (RBPs) to study and decipher the BC-triggering biological processes and pathways." 1 Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms. hsa_circ_0001666 hsa_circ_FAM120B - DOID:1612 breast cancer breast cancer microarray dysregulated "We combined several systems, biology tools and approaches to identify influential BC circRNAs, miRNAs, and related mRNAs as the members of competing endogenous RNAs (ceRNAs) networks and related RNA binding proteins (RBPs) to study and decipher the BC-triggering biological processes and pathways." 2 Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms. hsa_circ_0065173 hsa_circ_SETD2 - DOID:1612 breast cancer breast cancer microarray dysregulated "We combined several systems, biology tools and approaches to identify influential BC circRNAs, miRNAs, and related mRNAs as the members of competing endogenous RNAs (ceRNAs) networks and related RNA binding proteins (RBPs) to study and decipher the BC-triggering biological processes and pathways." 2 Circle RNA hsa_circRNA_100290 serves as a ceRNA for miR-378a to regulate oral squamous cell carcinoma cells growth via Glucose transporter-1 (GLUT1) and glycolysis. - - hsa_circRNA_100290 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "circRNA_100290 serves as a ceRNA to counteract miR-378a-mediated GLUT1 suppression, thus promoting glycolysis and cell proliferation in OSCC." 1 High-throughput sequencing reveals circular RNA hsa_circ_0000592 as a novel player in the carcinogenesis of gastric carcinoma. hsa_circ_0000592 hsa_circ_MGA - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated "This study is the first to identify hsa_circ_0000592 as a novel circRNA with a critical role in MNNG-induced gastric cancer. Due to the essential role of hsa_circ_0000592 in gastric carcinoma cells, it may be considered as a potential biomarker for use in diagnosing gastric carcinoma." 2 RNA sequencing reveals the circular RNA expression profiles of osteoarthritic synovium. hsa_circ_0037658 hsa_circ_CREBBP - DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" up-regulated The expressions of five downregulated circRNAs as well as an upregulated circRNA were confirmed through the use of qRT-PCR. 2 RNA sequencing reveals the circular RNA expression profiles of osteoarthritic synovium. hsa_circ_0001979 hsa_circ_SIPA1L1 - DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" down-regulated The expressions of five downregulated circRNAs as well as an upregulated circRNA were confirmed through the use of qRT-PCR. 1 RNA sequencing reveals the circular RNA expression profiles of osteoarthritic synovium. hsa_circ_0005406 hsa_circ_PHACTR4 - DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" down-regulated The expressions of five downregulated circRNAs as well as an upregulated circRNA were confirmed through the use of qRT-PCR. 1 RNA sequencing reveals the circular RNA expression profiles of osteoarthritic synovium. hsa_circ_0008172 hsa_circ_PARD3B - DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" down-regulated The expressions of five downregulated circRNAs as well as an upregulated circRNA were confirmed through the use of qRT-PCR. 2 RNA sequencing reveals the circular RNA expression profiles of osteoarthritic synovium. hsa_circ_0015260 hsa_circ_C1orf9 - DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" down-regulated The expressions of five downregulated circRNAs as well as an upregulated circRNA were confirmed through the use of qRT-PCR. 1 RNA sequencing reveals the circular RNA expression profiles of osteoarthritic synovium. hsa_circ_0077425 hsa_circ_USP45 - DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" down-regulated The expressions of five downregulated circRNAs as well as an upregulated circRNA were confirmed through the use of qRT-PCR. 1 Circular RNA CDR1as acts as a sponge of miR-135b-5p to suppress ovarian cancer progression. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "CDR1as, acting as a sponge of miR-135b-5p, promotes the expression of HIF1AN and therefore plays a role in tumor inhibition." 3 Circular RNA screening from EIF3a in lung cancer. - hsa_circ_EIF3AS - DOID:1324 lung cancer lung cancer RT-qPCR dysregulated "This is the first study that exploits circRNAs screening from EIF3a in lung cancer, our findings provide a novel perspective on the function of EIF3a and circEIF3as in lung cancer." 1 "Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancer." hsa_circ_0001206 hsa_circ_CRKL - DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated The study revealed expression profiles and potential functions of circRNAs and demonstrated hsa_circ_0001206 played a suppressive role in the pathogenesis of PCa. 2 Circ-SERPINE2 promotes the development of gastric carcinoma by sponging miR-375 and modulating YWHAZ. - hsa_circ_SERPINE2 circ-SERPINE2 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ-SERPINE2 is a novel proliferative promoter through the regulation of miR-375/YWHAZ. Circ-SERPINE2/miR-375/YWHAZ axis might provide a novel therapeutic target of GC. 1 CircSAMD4A accelerates cell proliferation of osteosarcoma by sponging miR-1244 and regulating MDM2 mRNA expression. - hsa_circ_SAMD4A - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circSAMD4A/miR-1244/MDM2 regulatory loop might be a promising therapeutic target for OS treatment. 2 CircRNA_28313/miR-195a/CSF1 axis modulates osteoclast differentiation to affect OVX-induced bone absorption in mice. - - circRNA_28313 DOID:11476 osteoporosis osteoporosis "RT-qPCR, microarray" dysregulated "circRNA_28313, miR-195a, and CSF1 form a ceRNA network to function in RANKL + CSF1-induced osteoclast differentiation, thus affecting OVX-induced bone absorption in mice." 1 circ-PKD2 inhibits carcinogenesis via the miR-204-3p/APC2 axis in oral squamous cell carcinoma. - hsa_circ_PKD2 circ-PKD2 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma microarray down-regulated These results demonstrate that the circ-PKD2/miR-204-3p/APC2 axis represents a novel pathway involved in the pathogenesis of OSCC and may serve as a novel therapeutic target of OSCC. 2 Linear and circular CDKN2B-AS1 expression is associated with Inflammatory Bowel Disease and participates in intestinal barrier formation. - hsa_circ_CDKN2B-AS1 - DOID:0050589 inflammatory bowel disease inflammatory bowel disease RT-qPCR down-regulated Linear and circular CDKN2B-AS1 expression is associated with Inflammatory Bowel Disease and participates in intestinal barrier formation. 1 hsa_circ_0091570 acts as a ceRNA to suppress hepatocellular cancer progression by sponging hsa-miR-1307. hsa_circ_0091570 hsa_circ_MBNL3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated hsa_circ_0091570 sponge miR-1307 as a ceRNA and regulate ISM1 expression by exerting functional roles in HCC. 2 Circular RNA Expression Profiling and the Potential Role of hsa_circ_0089172 in Hashimoto Thyroiditis via Sponging miR125a-3p. hsa_circ_0089172 hsa_circ_NUP214 - DOID:7166 thyroiditis Hashimoto thyroiditis RNA-seq up-regulated these results demonstrate that hsa_circ_0089172 as a potential diagnostic biomarker of HT and may play a crucial role in the pathogenesis of HT via sponging miR-125a-3p. 1 CircRAD23B facilitates proliferation and invasion of esophageal cancer cells by sponging miR-5095. - hsa_circ_RAD23B circRAD23B DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "In summary, these data displayed the crucial role of circRAD23B/miR-5095 regulating PARP2 and AKT2 in esophageal cancer, and provided a novel mechanism in the pathogenesis of esophageal cancer." 1 Circ-0104631 promotes cell proliferation and invasion in colorectal cancer and predicts poor prognosis. hsa_circ_0104631 - circ-0104631 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ-0104631 was highly expressed in CRC tissues. Furthermore, knockdown of Circ-0104631 could inhibit the growth and metastasis of CRC cells by regulating PTEN/Akt/mTOR signaling pathway." 1 Circular RNA profile of parathyroid neoplasms: analysis of co-expression networks of circular RNAs and mRNAs. hsa_circ_0075005 hsa_circ_NPM1 - DOID:1540 parathyroid carcinoma parathyroid carcinoma RT-qPCR up-regulated "This study demonstrates that hsa_circ_0075005 and MYC mRNA may be used for the differential diagnosis of PC and PA. The expression levels of hsa_circ_0035563 are related to CDC73 mutations and recurrence in malignancy, highlighting the significance of this parameter in prognosis of PC patients." 1 Circular RNA hsa_circ_009755 downregulation correlates with clinicopathology in oral squamous cell carcinoma. - - hsa_circ_009755 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR dysregulated Our data indicates that hsa_circ_009755 could serve as a potential biomarker for OSCC diagnosis. 2 circANKS1B regulates FOXM1 expression and promotes cell migration and invasion by functioning as a sponge of the miR-149 in colorectal cancer. - hsa_circ_ANKS1B - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circANKS1B promotes colorectal cancer cell migration and invasion by acting as a molecular sponge of miR-149 to modulate FOXM1 and Slug protein levels. 1 Cecal CircRNAs Are Associated With the Response to Salmonella Enterica Serovar Enteritidis Inoculation in the Chicken. - - chr1:132593578-132598993 DOID:2326 gastroenteritis salmonella enterica erovar enteritidis RNA-seq down-regulated "CircRNAs NC_006091.4: 65510578|65515090, NC_006099.4: 16132825|16236906, and NC_006099.4: 15993284|16006290 play important roles in the response to SE inoculation." 1 Cecal CircRNAs Are Associated With the Response to Salmonella Enterica Serovar Enteritidis Inoculation in the Chicken. - - chr5:52223625-52225021 DOID:2326 gastroenteritis salmonella enterica erovar enteritidis RNA-seq down-regulated "CircRNAs NC_006091.4: 65510578|65515090, NC_006099.4: 16132825|16236906, and NC_006099.4: 15993284|16006290 play important roles in the response to SE inoculation." 1 Cecal CircRNAs Are Associated With the Response to Salmonella Enterica Serovar Enteritidis Inoculation in the Chicken. - - chr20:13405274-13406817 DOID:2326 gastroenteritis salmonella enterica erovar enteritidis RNA-seq up-regulated "CircRNAs NC_006091.4: 65510578|65515090, NC_006099.4: 16132825|16236906, and NC_006099.4: 15993284|16006290 play important roles in the response to SE inoculation." 1 A potential significance of circ_0024169 down regulation in angiosarcoma tissue. hsa_circ_0024169 hsa_circ_CUL5 - DOID:0001816 angiosarcoma angiosarcoma RT-qPCR down-regulated "circ_0024169/CUL5 ratio are likely to be useful as a diagnostic biomarker for vascular tumors, whereas circ_0024169 levels may have more potential as a prognostic marker of angiosarcoma." 1 Identification of circular RNA-microRNA-messenger RNA regulatory network in hepatocellular carcinoma by integrated analysis. - - hsa_circRNA_104268 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "We speculate that hsa_circRNA_104268/hsa-miR-214-3p/E2F2, hsa_circRNA_104168/hsa-miR-139-5p/HRAS, and hsa_circRNA_104769/hsa-miR-93-5p/JUN interaction pairs may play a vital role in HCC. This study expected to provide a novel insight into the pathogenesis and therapy of HCC from the circRNA-miRNA-mRNA network view." 1 Identification of circular RNA-microRNA-messenger RNA regulatory network in hepatocellular carcinoma by integrated analysis. - - hsa_circRNA_104168 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "We speculate that hsa_circRNA_104268/hsa-miR-214-3p/E2F2, hsa_circRNA_104168/hsa-miR-139-5p/HRAS, and hsa_circRNA_104769/hsa-miR-93-6p/JUN interaction pairs may play a vital role in HCC. This study expected to provide a novel insight into the pathogenesis and therapy of HCC from the circRNA-miRNA-mRNA network view." 1 Identification of circular RNA-microRNA-messenger RNA regulatory network in hepatocellular carcinoma by integrated analysis. - - hsa_circRNA_104769 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "We speculate that hsa_circRNA_104268/hsa-miR-214-3p/E2F2, hsa_circRNA_104168/hsa-miR-139-5p/HRAS, and hsa_circRNA_104769/hsa-miR-93-7p/JUN interaction pairs may play a vital role in HCC. This study expected to provide a novel insight into the pathogenesis and therapy of HCC from the circRNA-miRNA-mRNA network view." 1 circRNA_0058097 promotes tension-induced degeneration of endplate chondrocytes by regulating HDAC4 expression through sponge adsorption of miR-365a-5p. hsa_circ_0058097 hsa_circ_FN1 circRNA_0058097 DOID:6227 articular cartilage disease endplate cartilage degeneration RT-qPCR up-regulated circRNA_0058097 promotes tension-induced degeneration of endplate chondrocytes by regulating HDAC4 expression through sponge adsorption of miR-365a-5p. 1 Enhanced expression of circular RNA circ-DCAF6 predicts adverse prognosis and promotes cell progression via sponging miR-1231 and miR-1256 in gastric cancer. - hsa_circ_DCAF6 circ-DCAF6 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circ-DCAF6 acts as an important role in GC tumor progression, and high circ-DCAF6 level may be a useful biomarker for GC." 2 circMTO1 promotes tumorigenesis and chemoresistance of cervical cancer via regulating miR-6893. - hsa_circ_MTO1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated A novel mechanism of circMTO1/miR-6893 in tumorigenesis and chemoresistance of cervical cancer. 2 Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN. - hsa_circ_SLC8A1 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "CircSLC8A1 acts as a tumor suppressor by a novel circSLC8A1/miR-130b, miR-494/PTEN axis, which may provide a potential biomarker and therapeutic target for the management of bladder cancer." 1 "hsa_circ_0006168 sponges miR-100 and regulates mTOR to promote the proliferation, migration and invasion of esophageal squamous cell carcinoma." hsa_circ_0006168 hsa_circ_CNOT6L - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma microarray up-regulated "hsa_circ_0006168 can promote ESCC proliferation, migration and invasion through the competing endogenous RNA (ceRNA) mechanism, which has been first confirmed in our results." 3 Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPKalpha signaling in STK11 mutant lung cancer. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated These results support that circHIPK3 is a key autophagy regulator in a subset of lung cancer and has potential clinical use as a prognostic factor. The circular RNA HIPK3(circHIPK3) functions as an oncogene and autophagy regulator may potential use as a prognostic marker and therapeutic target in lung cancer. 4 Non-coding RNA-Associated ceRNA Networks in a New Contrast-Induced Acute Kidney Injury Rat Model. - - novel_circ_0004153 DOID:557 kidney disease contrast-induced acute kidney injury RNA-seq up-regulated two constructed ceRNA regulatory pathways in this CI-AKI rat model-novel_circ_0004153/rno-miR-144-3p/Gpnmb or Naglu and LNC_000343/rno-miR-1956-5p/KCP-were validated by real-time qPCR. This study is the first one to provide a systematic dissection of non-coding RNA-associated ceRNA profiling in kidney of CI-AKI rats. 1 circRNA_0016624 could sponge miR-98 to regulate BMP2 expression in postmenopausal osteoporosis. hsa_circ_0016624 hsa_circ_DNAH14 circRNA_0016624 DOID:11476 osteoporosis osteoporosis "RT-qPCR, RNA-seq" down-regulated "circRNA_0016624 could sponge miR-98 and enhance BMP2 expression, thus circRNA_0016624 prevents osteoporosis and may provide a novel therapeutic strategy." 1 The RNA-binding protein RBM3 promotes cell proliferation in hepatocellular carcinoma by regulating circular RNA SCD-circRNA 2 production. - - SCD-circRNA 2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "RBM3 overexpression was indicative of a short recurrence-free survival and poor overall survival for HCC patients. Furthermore, by modulating the RBM3 or SCD-circRNA 2 levels, we found that RBM3 promoted the HCC cell proliferation in a SCD-circRNA 2 dependent manner." 1 Circular RNA circPIP5K1A promotes non-small cell lung cancer proliferation and metastasis through miR-600/HIF-1alpha regulation. - hsa_circ_PIP5K1A - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circPIP5K1A acted as a tumor promoter through a novel circPIP5K1A/miR-600/HIF-1alpha axis, which provides candidate markers and therapeutic targets for NSCLC." 4 CircAGFG1 sponges miR-203 to promote EMT and metastasis of non-small-cell lung cancer by upregulating ZNF281 expression. - hsa_circ_AGFG1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated our study suggests that circAGFG1 promotes NSCLC growth and metastasis though a circAGFG1/miR-203/ZNF281 axis and may represent a novel therapeutic target. 2 Hsa_circ_0001946 Inhibits Lung Cancer Progression and Mediates Cisplatin Sensitivity in Non-small Cell Lung Cancer via the Nucleotide Excision Repair Signaling Pathway. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our study demonstrated the role of hsa_circ_0001946 in NSCLC pathogenesis, development, and chemosensitivity, and suggests that hsa_circ_0001946 may serve as a novel biomarker for the diagnosis and prediction of platinum-based chemosensitivity in patients with NSCLC." 5 Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection. - hsa_circ_MARK3 - DOID:0080685 aortic dissection acute stanford type a aortic dissection RNA-seq up-regulated These results provided a preliminary landscape of circRNAs expression profiles and indicated that circMARK3 was a potential biomarker for AAAD diagnosis. 1 High-Throughput Data Reveals Novel Circular RNAs via Competitive Endogenous RNA Networks Associated with Human Intracranial Aneurysms. hsa_circ_0072309 hsa_circ_LIFR - DOID:10941 intracranial aneurysm intracranial aneurysm RT-qPCR down-regulated "To the best of our knowledge, this is the first study to perform circRNA sequencing analysis of IAs. hsa_circ_0072309 and hsa_circ_0008433 are novel and pivotal circRNAs related to IAs." 1 High-Throughput Data Reveals Novel Circular RNAs via Competitive Endogenous RNA Networks Associated with Human Intracranial Aneurysms. hsa_circ_0008433 hsa_circ_PDE4B - DOID:10941 intracranial aneurysm intracranial aneurysm RT-qPCR down-regulated "To the best of our knowledge, this is the first study to perform circRNA sequencing analysis of IAs. hsa_circ_0072309 and hsa_circ_0008433 are novel and pivotal circRNAs related to IAs." 1 CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression. - hsa_circ_NR3C1 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "our findings further confirm the hypothesis that circRNAs function as microRNA sponges, and our data suggest that circNR3C1 and miR-27a-3p would be potential therapeutic targets for bladder cancer treatment." 2 MicroRNA-148a-3p promotes survival and migration of endothelial cells isolated from Apoe deficient mice through restricting circular RNA 0003575. hsa_circ_0003575 hsa_circ_CHMP5 circular RNA 0003575 DOID:1936 atherosclerosis atherosclerosis RT-qPCR dysregulated "We demonstrate that miR-148a-3p suppresses FOXO4 and FOXO3 expression via interruption of circ_0003575 function, which in turn impairs the proliferative and migratory function of endothelial cells, eventually exacerbating the atherosclerosis." 3 "hsa_circ_0000745 promotes cervical cancer by increasing cell proliferation, migration, and invasion." hsa_circ_0000745 hsa_circ_SPECC1 - DOID:4362 cervical cancer cervical cancer microarray up-regulated "As a tumor promoter in CC, hsa_circ_0000745 enhances the cells ability to proliferate, migrate, and invade by reducing the expression of E-cad." 2 Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335. - hsa_circ_EIF4G3 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our study demonstrates that circ-EIF4G3 promotes the proliferation, invasion and migration of gastric cancer via sponging miR-335." 4 "The role of circular RNA HECTD1 expression in disease risk, disease severity, inflammation, and recurrence of acute ischemic stroke." - hsa_circ_HECTD1 - DOID:6713 cerebrovascular disease stroke RT-qPCR up-regulated "CircRNA HECTD1 expression correlates with higher disease risk, disease severity, inflammation, and recurrence of AIS." 3 Circular RNA expression profile in peripheral blood mononuclear cells from Crohn disease patients. - - circRNA_004662 DOID:8778 Crohn disease Crohn disease RT-qPCR up-regulated circRNA_004662 might be a novel candidate for differentiating CD from UC. 1 Differential circular RNA expression profiles of invasive and non-invasive non-functioning pituitary adenomas: A microarray analysis. - - circRNA_069718 DOID:3829 pituitary adenoma pituitary adenoma microarray down-regulated Hsa_circRNA_102597 alone or in combined with Ki-67 index was able to accurately differentiate invasive from non-invasive NFPAs as well as predict tumor progression/recurrence. 1 Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks. hsa_circ_0009029 hsa_circ_ZNF462 circ_0009029 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis RT-qPCR dysregulated "Two lncRNAs (Sngh1 and Slc36a3os) and four circRNAs (circ_0009029, circ_0004572, circ_0009212 and circ_0009453) in competing endogenous RNA (ceRNA) networks were constructed by Cytoscape, and immune-related mRNAs (e.g., Cd28, Cd8a, Il15, and Klrk1) were involved in the ceRNA networks." 1 Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks. hsa_circ_0004572 hsa_circ_RAI14 circ_0004572 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis RT-qPCR dysregulated "Two lncRNAs (Sngh1 and Slc36a3os) and four circRNAs (circ_0009029, circ_0004572, circ_0009212 and circ_0009453) in competing endogenous RNA (ceRNA) networks were constructed by Cytoscape, and immune-related mRNAs (e.g., Cd28, Cd8a, Il15, and Klrk1) were involved in the ceRNA networks." 1 Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks. hsa_circ_0009212 hsa_circ_AGRN circ_0009212 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis RT-qPCR dysregulated "Two lncRNAs (Sngh1 and Slc36a3os) and four circRNAs (circ_0009029, circ_0004572, circ_0009212 and circ_0009453) in competing endogenous RNA (ceRNA) networks were constructed by Cytoscape, and immune-related mRNAs (e.g., Cd28, Cd8a, Il15, and Klrk1) were involved in the ceRNA networks." 1 Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks. hsa_circ_0009453 hsa_circ_NPHP4 circ_0009453 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis RT-qPCR dysregulated "Two lncRNAs (Sngh1 and Slc36a3os) and four circRNAs (circ_0009029, circ_0004572, circ_0009212 and circ_0009453) in competing endogenous RNA (ceRNA) networks were constructed by Cytoscape, and immune-related mRNAs (e.g., Cd28, Cd8a, Il15, and Klrk1) were involved in the ceRNA networks." 1 Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR-1179/ABCA9 and miR-1205/MTA1 signaling pathways. hsa_circ_0039411 hsa_circ_MMP2 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR-1179/ABCA9 and miR-1205/MTA1 signaling pathways. 2 Circular RNA circABCC4 as the ceRNA of miR-1182 facilitates prostate cancer progression by promoting FOXP4 expression. - hsa_circ_ABCC4 - DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated "Taken together, our findings indicated that circABCC4 facilitates the malignant behaviour of prostate cancer by promoting FOXP4 expression through sponging of miR-1182." 2 Systematic identification of lncRNAs and circRNAs-associated ceRNA networks in human lumbar disc degeneration. hsa_circ_0005139 hsa_circ_RDH11 - DOID:90 degenerative disc disease lumbar disc degeneration microarray dysregulated "Three circRNAs, hsa_circ_0005139, hsa_circ_0037858, and hsa_circ_0087890, were identified as key regulators of LDD progression." 1 Systematic identification of lncRNAs and circRNAs-associated ceRNA networks in human lumbar disc degeneration. hsa_circ_0037858 hsa_circ_LITAF - DOID:90 degenerative disc disease lumbar disc degeneration microarray dysregulated "Three circRNAs, hsa_circ_0005139, hsa_circ_0037858, and hsa_circ_0087890, were identified as key regulators of LDD progression." 1 Systematic identification of lncRNAs and circRNAs-associated ceRNA networks in human lumbar disc degeneration. hsa_circ_0087890 hsa_circ_C9orf5 - DOID:90 degenerative disc disease lumbar disc degeneration microarray dysregulated "Three circRNAs, hsa_circ_0005139, hsa_circ_0037858, and hsa_circ_0087890, were identified as key regulators of LDD progression." 1 circ-NOTCH1 acts as a sponge of miR-637 and affects the expression of its target gene Apelin to regulate gastric cancer cell growth. - hsa_circ_NOTCH1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "in GC cells, circ-NOTCH1 inhibits the transcriptional activity of miR-637, thereby upregulating the expression of its target gene Apelin and regulating cell proliferation, apoptosis, and invasiveness." 3 Identification of long non-coding RNA and circular RNA in mice after intra-tracheal instillation with fine particulate matter - mmu_circ_CBT15 CBT15_circR_1011 DOID:552 pneumonia lung inflammation "RT-qPCR, RNA-seq" down-regulated "The upregulated expressions of lncRNA NONMMUT065867, lncRNA NONMMUT064312, lncRNA NONMMUT018123 and the downregulated expressions of circRNA CBT15_circR_1011, circRNA mm9_circ_005915 were identified by qRT-PCR in PM2.5 group" 1 Identification of long non-coding RNA and circular RNA in mice after intra-tracheal instillation with fine particulate matter - - mm9_circ_005915 DOID:552 pneumonia lung inflammation "RT-qPCR, RNA-seq" down-regulated "The upregulated expressions of lncRNA NONMMUT065867, lncRNA NONMMUT064312, lncRNA NONMMUT018123 and the downregulated expressions of circRNA CBT15_circR_1011, circRNA mm9_circ_005915 were identified by qRT-PCR in PM2.5 group" 1 CircRNA-104718 acts as competing endogenous RNA and promotes hepatocellular carcinoma progression through microRNA-218-5p/TXNDC5 signaling pathway. - - circRNA-104718 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated our results indicate that circRNA-104718 acts as a ceRNA and promotes HCC progression through the targeting of miR-218-5p/TXNDC5 signaling pathway. 1 Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma. - hsa_circ_ZKSCAN1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray down-regulated this study revealed the mechanisms underlying the regulatory role of circZKSCAN1 in HCC CSCs and identified the newly discovered Qki5-circZKSCAN1-FMRP-CCAR1-Wnt signaling axis as a potentially important therapeutic target for HCC treatment. 3 Circular RNA profiling identified as a biomarker for predicting the efficacy of Gefitinib therapy for non-small cell lung cancer. hsa_circ_0109320 hsa_circ_ZNF91 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR dysregulated "Taken together, hsa_circ_0109320 may be a potential biomarker for the efficacy of EGFR-TKI in NSCLC patients." 2 Blood circRNAs as biomarkers for the diagnosis of community-acquired pneumonia. hsa_circ_0018429 hsa_circ_BICC1 - DOID:552 pneumonia community-acquired pneumonia "RT-qPCR, microarray" up-regulated we generated a genetic network of potential CAP-related regulatory interactions that should inform future hypothesis-driven research into the causes and potential treatment of this widespread and frequently fatal disease. 1 Blood circRNAs as biomarkers for the diagnosis of community-acquired pneumonia. hsa_circ_0026579 hsa_circ_ESPL1 - DOID:552 pneumonia community-acquired pneumonia "RT-qPCR, microarray" up-regulated we generated a genetic network of potential CAP-related regulatory interactions that should inform future hypothesis-driven research into the causes and potential treatment of this widespread and frequently fatal disease. 1 Blood circRNAs as biomarkers for the diagnosis of community-acquired pneumonia. hsa_circ_0125357 hsa_circ_SLC7A11 - DOID:552 pneumonia community-acquired pneumonia "RT-qPCR, microarray" up-regulated we generated a genetic network of potential CAP-related regulatory interactions that should inform future hypothesis-driven research into the causes and potential treatment of this widespread and frequently fatal disease. 1 Blood circRNAs as biomarkers for the diagnosis of community-acquired pneumonia. hsa_circ_0099188 hsa_circ_TRHDE - DOID:552 pneumonia community-acquired pneumonia "RT-qPCR, microarray" up-regulated we generated a genetic network of potential CAP-related regulatory interactions that should inform future hypothesis-driven research into the causes and potential treatment of this widespread and frequently fatal disease. 2 The potential targets for metastases: a study on altered circular RNA profile in breast cancer liver metastases. - - hsa circ 21439 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "The altered expressed circRNAs were found in BCLM tissues, compared with primary tumor tissues. These circRNAs involved in metastatic related signaling pathways. Hsa_circ_21439 and hsa_circ_11783 were verified to be the most significantly up- and downregulated circRNAs in both BCLM tissues and cells._n silico circRNA/miRNA analysis revealed that has_circ_21439 and has_circ_11783 could act as miRNA sponge." 1 The potential targets for metastases: a study on altered circular RNA profile in breast cancer liver metastases. - - hsa circ 11783 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "The altered expressed circRNAs were found in BCLM tissues, compared with primary tumor tissues. These circRNAs involved in metastatic related signaling pathways. Hsa_circ_21439 and hsa_circ_11783 were verified to be the most significantly up- and downregulated circRNAs in both BCLM tissues and cells._n silico circRNA/miRNA analysis revealed that has_circ_21439 and has_circ_11783 could act as miRNA sponge." 1 Circular RNA Signature in Hepatocellular Carcinoma. hsa_circ_0001806 hsa_circ_CSPP1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Six circRNAs were validated to be greatly up-regulated in HepG2 cells compared with L02 cells, including hsa_circ_0001806, hsa_circ_0003528, hsa_circ_0008583, hsa_circ_0009910, hsa_circ_0032704, and hsa_circ_0065214; while hsa_circ_0007762 was found to be greatly down-regulated in HepG2 cells compared with L02 cells." 6 Circular RNA Signature in Hepatocellular Carcinoma. hsa_circ_0003528 hsa_circ_SEC24A - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Six circRNAs were validated to be greatly up-regulated in HepG2 cells compared with L02 cells, including hsa_circ_0001806, hsa_circ_0003528, hsa_circ_0008583, hsa_circ_0009910, hsa_circ_0032704, and hsa_circ_0065214; while hsa_circ_0007762 was found to be greatly down-regulated in HepG2 cells compared with L02 cells." 4 Circular RNA Signature in Hepatocellular Carcinoma. hsa_circ_0008583 hsa_circ_DLG1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Six circRNAs were validated to be greatly up-regulated in HepG2 cells compared with L02 cells, including hsa_circ_0001806, hsa_circ_0003528, hsa_circ_0008583, hsa_circ_0009910, hsa_circ_0032704, and hsa_circ_0065214; while hsa_circ_0007762 was found to be greatly down-regulated in HepG2 cells compared with L02 cells." 3 Circular RNA Signature in Hepatocellular Carcinoma. hsa_circ_0009910 hsa_circ_MFN2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Six circRNAs were validated to be greatly up-regulated in HepG2 cells compared with L02 cells, including hsa_circ_0001806, hsa_circ_0003528, hsa_circ_0008583, hsa_circ_0009910, hsa_circ_0032704, and hsa_circ_0065214; while hsa_circ_0007762 was found to be greatly down-regulated in HepG2 cells compared with L02 cells." 3 Circular RNA Signature in Hepatocellular Carcinoma. hsa_circ_0032704 hsa_circ_TTLL5 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Six circRNAs were validated to be greatly up-regulated in HepG2 cells compared with L02 cells, including hsa_circ_0001806, hsa_circ_0003528, hsa_circ_0008583, hsa_circ_0009910, hsa_circ_0032704, and hsa_circ_0065214; while hsa_circ_0007762 was found to be greatly down-regulated in HepG2 cells compared with L02 cells." 2 Circular RNA Signature in Hepatocellular Carcinoma. hsa_circ_0065214 hsa_circ_SCAP - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Six circRNAs were validated to be greatly up-regulated in HepG2 cells compared with L02 cells, including hsa_circ_0001806, hsa_circ_0003528, hsa_circ_0008583, hsa_circ_0009910, hsa_circ_0032704, and hsa_circ_0065214; while hsa_circ_0007762 was found to be greatly down-regulated in HepG2 cells compared with L02 cells." 1 Circular RNA Signature in Hepatocellular Carcinoma. hsa_circ_0007762 hsa_circ_STXBP5 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated "Six circRNAs were validated to be greatly up-regulated in HepG2 cells compared with L02 cells, including hsa_circ_0001806, hsa_circ_0003528, hsa_circ_0008583, hsa_circ_0009910, hsa_circ_0032704, and hsa_circ_0065214; while hsa_circ_0007762 was found to be greatly down-regulated in HepG2 cells compared with L02 cells." 1 Identification of Circular RNA Related to Inflammation-Induced Lymphangiogenesis by Microarray Analysis - hsa_circ_ZNF609 cZNF609 DOID:9317 lymphangitis inflammation-induced lymphangiogenesis (LG) RT-qPCR up-regulated circRNAs may serve as potential regulators of corneal LG. 1 KHDRBS3 regulates the permeability of blood-tumor barrier via cDENND4C/miR-577 axis. - hsa_circ_DENND4C cDENND4C DOID:0060108 brain glioma glioma RT-qPCR up-regulated "the present study indicated that KHDRBS3 could regulate BTB permeability through the cDENND4C/miR-577 axis, which enhanced doxorubicin delivery across BTB." 1 hsa_circRNA_100533 regulates GNAS by sponging hsa_miR_933 to prevent oral squamous cell carcinoma. - - hsa_circRNA_100533 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq, microarray" down-regulated the hsa_circRNA_100533-miR-933-GNAS axis affect the proliferation and apoptosis of OSCC cells through the mechanism of competing endogenous RNAs. 1 "SKP2, positively regulated by circ_ODC1/miR-422a axis, promotes the proliferation of retinoblastoma." - hsa_circ_ODC1 - DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated "SKP2, induced by circ_ODC1 and miR-422a, promotes RB proliferation. Our new findings in this research might expedite the discovery of novel prognostic markers and therapeutic targets of RB." 1 Circular RNA circ-SMAD7 promoted ovarian cancer cell proliferation and metastasis by suppressing KLF6. - hsa_circ_SMAD7 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Our study suggests that circ-SMAD7 promotes the progression of ovarian cancer and enhances cell metastasis and proliferation via suppressing KLF6. In addition, circ-SMAD7 may be a novel therapeutic strategy in ovarian cancer." 1 CircRNA_069718 promotes cell proliferation and invasion in triple-negative breast cancer by activating Wnt/beta-catenin pathway. - - circRNA_069718 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Our findings suggested that circRNA_069718 promoted TNBC progression via Wnt/beta-catenin pathway and could serve as a novel therapeutic target for TNBC treatment. 1 Hsa_circ_101555 functions as a competing endogenous RNA of miR-597-5p to promote colorectal cancer progression. - - hsa_circ_101555 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated our results proved that circ101555 might function as a competing endogenous RNA of miR-597-5p to up-regulate CDK6 and RPA3 expression in CRC. 1 Circular RNA circCRIM1 inhibits invasion and metastasis in lung adenocarcinoma through the microRNA (miR)-182/miR-93-leukemia inhibitory factor receptor pathway. - hsa_circ_CRIM1 - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq, microarray" down-regulated Our study showed that circCRIM1 inhibits the invasion and metastasis of lung adenocarcinoma cancer cells. 2 Targeting the circBMPR2/miR-553/USP4 Axis as a Potent Therapeutic Approach for Breast Cancer. - hsa_circ_BMPR2 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq, microarray" down-regulated Our findings demonstrated that circBMPR2 might function as a miR-553 sponge and then relieve the suppression of USP4 to inhibit the progression and tamoxifen resistance of breast cancer. 1 circ_0001730 promotes proliferation and invasion via the miR-326/Wnt7B axis in glioma cells. hsa_circ_0001730 hsa_circ_EPHB4 circ_0001730 DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq, microarray" up-regulated circ_000173 promoted growth and invasion in glioblastoma cells via the miR-326/Wnt7B axis. 3 "Downregulated circular RNA itchy E3 ubiquitin protein ligase correlates with advanced pathologic T stage, high lymph node metastasis risk and poor survivals in prostate cancer patients." - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated "circ-ITCH is downregulated in prostate cancer tissues, and its low expression correlates with advanced pathologic T stage, high lymph mode metastasis risk and poor survival in prostate cancer patients underwent radical prostatectomy." 2 Circular RNA circHIPK3 serves as a prognostic marker to promote chronic myeloid leukemia progression. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:8552 chronic myeloid leukemia chronic myeloid leukemia RT-qPCR up-regulated High circHIPK3 expression predicted a poor outcome of CML patients. 1 Analysis of the circular RNA transcriptome in the grade 3 endometrial cancer. hsa_circ_0039569 hsa_circ_CCL22 - DOID:1380 endometrial cancer endometrial cancer "RT-qPCR, RNA-seq" up-regulated "Furthermore, the regulation of hsa_circ_0039569-hsa-miR -542-3p/hsa-let-7c-5p axis was initially predicted in the grade 3 EC." 3 Analysis of the circular RNA transcriptome in the grade 3 endometrial cancer. hsa_circ_0001610 hsa_circ_TNFRSF21 - DOID:1380 endometrial cancer endometrial cancer "RT-qPCR, RNA-seq" up-regulated "Furthermore, the regulation of hsa_circ_0039569-hsa-miR -542-3p/hsa-let-7c-5p axis was initially predicted in the grade 3 EC." 3 Analysis of the circular RNA transcriptome in the grade 3 endometrial cancer. hsa_circ_0000437 hsa_circ_CORO1C - DOID:1380 endometrial cancer endometrial cancer "RT-qPCR, RNA-seq" down-regulated "Furthermore, the regulation of hsa_circ_0039569-hsa-miR -542-3p/hsa-let-7c-5p axis was initially predicted in the grade 3 EC." 2 Analysis of the circular RNA transcriptome in the grade 3 endometrial cancer. hsa_circ_0001776 hsa_circ_ESYT2 - DOID:1380 endometrial cancer endometrial cancer "RT-qPCR, RNA-seq" down-regulated "Furthermore, the regulation of hsa_circ_0039569-hsa-miR -542-3p/hsa-let-7c-5p axis was initially predicted in the grade 3 EC." 1 Analysis of the circular RNA transcriptome in the grade 3 endometrial cancer. hsa_circ_0009043 hsa_circ_EXOC6B - DOID:1380 endometrial cancer endometrial cancer "RT-qPCR, RNA-seq" down-regulated "Furthermore, the regulation of hsa_circ_0039569-hsa-miR -542-3p/hsa-let-7c-5p axis was initially predicted in the grade 3 EC." 1 Circular RNA TLK1 Aggravates Neuronal Injury and Neurological Deficits after Ischemic Stroke via miR-335-3p/TIPARP. - hsa_circ_TLK1 - DOID:6713 cerebrovascular disease stroke RT-qPCR dysregulated Circular RNA TLK1 Aggravates Neuronal Injury and Neurological Deficits after Ischemic Stroke via miR-335-3p/TIPARP. 3 Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR. - - circ_03848 DOID:409 liver disease liver regeneration RNA-seq dysregulated "And then, four kinds of circRNAs, including circ_03848, circ_08236, circ_13398 and circ_15013 were considered as the candidate key circRNAs and speculated to regulate cell proliferation at 12_72 h after PH by sponging miRNAs and modulating the downstream mRNAs, which based on the number of the corresponding miRNAs and their role enriched and reported in cell proliferation of LR or HCC. I." 1 Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR. - - circ_08236 DOID:409 liver disease liver regeneration RNA-seq dysregulated "And then, four kinds of circRNAs, including circ_03848, circ_08236, circ_13398 and circ_15013 were considered as the candidate key circRNAs and speculated to regulate cell proliferation at 12_73 h after PH by sponging miRNAs and modulating the downstream mRNAs, which based on the number of the corresponding miRNAs and their role enriched and reported in cell proliferation of LR or HCC. I." 1 Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR. - - circ_13398 DOID:409 liver disease liver regeneration RNA-seq dysregulated "And then, four kinds of circRNAs, including circ_03848, circ_08236, circ_13398 and circ_15013 were considered as the candidate key circRNAs and speculated to regulate cell proliferation at 12_74 h after PH by sponging miRNAs and modulating the downstream mRNAs, which based on the number of the corresponding miRNAs and their role enriched and reported in cell proliferation of LR or HCC. I." 1 Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR. - - circ_15013 DOID:409 liver disease liver regeneration RNA-seq dysregulated "And then, four kinds of circRNAs, including circ_03848, circ_08236, circ_13398 and circ_15013 were considered as the candidate key circRNAs and speculated to regulate cell proliferation at 12_75 h after PH by sponging miRNAs and modulating the downstream mRNAs, which based on the number of the corresponding miRNAs and their role enriched and reported in cell proliferation of LR or HCC. I." 1 Upregulation of Circular RNA CircNFIB Attenuates Cardiac Fibrosis by Sponging miR-433. - mmu_circ_NFIB - DOID:114 heart disease cardiac fibrosis RT-qPCR down-regulated Upregulation of Circular RNA CircNFIB Attenuates Cardiac Fibrosis by Sponging miR-433. 1 Circular RNA hsa_circRNA_103809 promoted hepatocellular carcinoma development by regulating miR-377-3p/FGFR1/ERK axis. - - hsa_circRNA_103809 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated hsa_circRNA_103809 promoted hepatocellular carcinoma development by regulating miR-377-3p/FGFR1/ERK axis. 1 Elevated levels of hsa_circ_006100 in gastric cancer promote cell growth and metastasis via miR-195/GPRC5A signalling. - - hsa_circ_006100 DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated Hsa_circ_006100 functions as an oncogene in gastric cancer and exerts its effects via miR-195/GPRC5A signalling. 1 circRNA_0006393 promotes osteogenesis in glucocorticoid_induced osteoporosis by sponging miR_145_5p and upregulating FOXO1. hsa_circ_0006393 hsa_circ_HIF1A - DOID:12347 osteogenesis imperfecta osteogenesis RT-qPCR down-regulated hsa_circ_0006393 increases the expression levels of osteogenic genes during bone remodeling by sponging miR_145_5p and upregulating FOXO1. 1 Expression of circular RNA CDR1_AS in colon cancer cells increases cell surface PD_L1 protein levels. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:219 colon cancer colon cancer RT-qPCR up-regulated CDR1as lead to poor prognosis by increasing cell surface PD_L1 levels through microRNA_7_independent mechanisms. 1 Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression. - hsa_circ_RHOT1 circRHOT1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression. 3 Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis. hsa_circ_0058124 hsa_circ_FN1 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated hsa_circ_0058124/NOTCH3/GATAD2A axis which is critical for PTC tumorigenesis and invasiveness. 2 circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1. - hsa_circ_TP63 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "circTP63 competitively binds to miR-873-3p and prevents miR-873-3p to decrease the level of FOXM1, which upregulates CENPA and CENPB, and finally facilitates cell cycle progression." 1 Circ_1639 induces cells inflammation responses by sponging miR-122 and regulating TNFRSF13C expression in alcoholic liver disease. - - circ_1639 DOID:12351 alcoholic hepatitis alcoholic liver disease RT-qPCR up-regulated inhibition of circ_1639 expression may reduce inflammatory responses in ALD. 1 Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues. hsa_circ_0067582 hsa_circ_RASA2 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues. 3 Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues. hsa_circ_0005758 hsa_circ_KIAA0907 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues. 3 Overexpression of circ_0021093 circular RNA forecasts an unfavorable prognosis and facilitates cell progression by targeting the miR-766-3p/MTA3 pathway in hepatocellular carcinoma. hsa_circ_0021093 - circ_0021093 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Overexpression of circ_0021093 circular RNA forecasts an unfavorable prognosis and facilitates cell progression by targeting the miR-766-3p/MTA3 pathway in hepatocellular carcinoma. 2 MicroRNA-191 promotes hepatocellular carcinoma cell proliferation by has_circ_0000204/miR-191/KLF6 axis. hsa_circ_0000204 hsa_circ_WDR37 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated metastasis-associated protein 3 (MTA3) was a direct target of miR-766-3p and that the oncogenic function of circ_0021093 was partly dependent on the miR-766-3p/MTA3 axis. 2 Upregulated Circular RNA circ-UBE2D2 Predicts Poor Prognosis and Promotes Breast Cancer Progression by Sponging miR-1236 and miR-1287. - hsa_circ_UBE2D2 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circ-UBE2D2 Predicts Poor Prognosis and Promotes Breast Cancer Progression by Sponging miR-1236 and miR-1287. 2 CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression. - hsa_circ_PLK1 circPLK1 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, RNA-seq" up-regulated CircPLK1-miR-296-5p-PLK1 axis regulates tumor progression by ceRNA mechanism in TNBC. 1 Circular RNA expression profiles in cisplatin-induced acute kidney injury in mice. - - chr1:179033093-179061227 DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" up-regulated "The qRT-PCR analysis showed that, compared with that in the control mice, the expression of circRNAs chr1:179033093|179061227, chr3:138209285|138218455 and chr19:5801227|5801816 was increased in the mice with cisplatin-induced AKI, whereas the expression of circRNAs chr1:13628312|13640965, chr5:24371897|24376910 and chr2:126906266|126911818 was decreased." 1 Circular RNA expression profiles in cisplatin-induced acute kidney injury in mice. - - chr3:138209285-138218455 DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" up-regulated "The qRT-PCR analysis showed that, compared with that in the control mice, the expression of circRNAs chr1:179033093|179061227, chr3:138209285|138218455 and chr19:5801227|5801816 was increased in the mice with cisplatin-induced AKI, whereas the expression of circRNAs chr1:13628312|13640965, chr5:24371897|24376910 and chr2:126906266|126911818 was decreased." 1 Circular RNA expression profiles in cisplatin-induced acute kidney injury in mice. - - chr19:5801227-5801816 DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" up-regulated "The qRT-PCR analysis showed that, compared with that in the control mice, the expression of circRNAs chr1:179033093|179061227, chr3:138209285|138218455 and chr19:5801227|5801816 was increased in the mice with cisplatin-induced AKI, whereas the expression of circRNAs chr1:13628312|13640965, chr5:24371897|24376910 and chr2:126906266|126911818 was decreased." 1 Circular RNA expression profiles in cisplatin-induced acute kidney injury in mice. - - chr1:13628312-13640965 DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" down-regulated "The qRT-PCR analysis showed that, compared with that in the control mice, the expression of circRNAs chr1:179033093|179061227, chr3:138209285|138218455 and chr19:5801227|5801816 was increased in the mice with cisplatin-induced AKI, whereas the expression of circRNAs chr1:13628312|13640965, chr5:24371897|24376910 and chr2:126906266|126911818 was decreased." 1 Circular RNA expression profiles in cisplatin-induced acute kidney injury in mice. - - chr5:24371897-24376910 DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" down-regulated "The qRT-PCR analysis showed that, compared with that in the control mice, the expression of circRNAs chr1:179033093|179061227, chr3:138209285|138218455 and chr19:5801227|5801816 was increased in the mice with cisplatin-induced AKI, whereas the expression of circRNAs chr1:13628312|13640965, chr5:24371897|24376910 and chr2:126906266|126911818 was decreased." 1 Circular RNA expression profiles in cisplatin-induced acute kidney injury in mice. - - chr2:126906266-126911818 DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" down-regulated "The qRT-PCR analysis showed that, compared with that in the control mice, the expression of circRNAs chr1:179033093|179061227, chr3:138209285|138218455 and chr19:5801227|5801816 was increased in the mice with cisplatin-induced AKI, whereas the expression of circRNAs chr1:13628312|13640965, chr5:24371897|24376910 and chr2:126906266|126911818 was decreased." 1 Circular RNAs are differentially expressed in prostate cancer and are potentially associated with resistance to enzalutamide. hsa_circ_0004870 hsa_circ_RBM39 - DOID:10283 prostate cancer prostate cancer microarray dysregulated "hsa_circ_0004870, through RBM39, may play a critical role in the development of enzalutamide resistance in CRPC." 1 Circular RNA circ_0008450 upregulates CXCL9 expression by targeting miR-577 to regulate cell proliferation and invasion in nasopharyngeal carcinoma. hsa_circ_0008450 hsa_circ_CMTM3 circ_0008450 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated circ_0008450 acts as an oncogene in NPC cells through regulating miR-577/CXCL9 signaling. 1 Circular RNA hsa_circ_0007142 Is Upregulated and Targets miR-103a-2-5p in Colorectal Cancer. hsa_circ_0007142 hsa_circ_DOCK1 - DOID:9256 colorectal cancer colorectal cancer microarray up-regulated hsa_circ_0007142 is upregulated in CRC and targets miR-103a-2-5p to promote CRC. 4 Circ_SPECC1 enhances the inhibition of miR-526b on downstream KDM4A/YAP1 pathway to regulate the growth and invasion of gastric cancer cells. - hsa_circ_SPECC1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "circ_SPECC1 can enhance miR-526b inhibitory effect on downstream KDM4A/YAP1 pathway by adsorbing it, thus inhibiting GC cell growth and invasion." 2 Circular RNA hsa_circ_0007059 restrains proliferation and epithelial-mesenchymal transition in lung cancer cells via inhibiting microRNA-378. hsa_circ_0007059 hsa_circ_ZNF720 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated hsa_circ_0007059 abated cell proliferation and EMT process in lung cancer cells via inactivation of Wnt/beta-catenin and ERK1/2 pathways via suppressing miR-378. 1 CircTRNC18 inhibits trophoblast cell migration and epithelial-mesenchymal transition by regulating miR-762/Grhl2 pathway in pre-eclampsia. - hsa_circ_TRNC18 - DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated circTNRC18/miR-762/Grhl2 axis plays a key role in trophoblast cell migration and EMT. circTNRC18/miR-762/Grhl2 axis may be a potential therapeutic target in PE. 1 CircRNA hsa_circ_0004585 as a potential biomarker for colorectal cancer. hsa_circ_0004585 hsa_circ_KIAA1199 - DOID:9256 colorectal cancer colorectal cancer microarray up-regulated Hsa_circ_0004585 could be a potential biomarker for diagnosis of CRC. 3 MiR-1261/circ-PTPRZ1/PAK1 pathway regulates glioma cell growth and invasion. - hsa_circ_PTPRZ1 circPTPRZ1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "in glioma cells, the expression of circ-PTPRZ1/PAK1 is regulated by miR-1261, which affects the proliferation, apoptosis, and invasion." 1 Circular RNA circVAPA Promotes Cell Proliferation in Hepatocellular Carcinoma. - hsa_circ_VAPA - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circVAPA contributes to HCC cell proliferation through sponging miR-377-3p and thereby disinhibiting PSAP. 2 Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells. hsa_circ_0008360 hsa_circ_XPNPEP3 - DOID:9351 diabetes mellitus diabetes-associated endothelial dysfunction "RT-qPCR, RNA-seq" dysregulated Our work highlights the potential regulatory mechanisms of three crucial circRNAs in diabetes-associated endothelial dysfunction. 1 Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells. hsa_circ_0005741 hsa_circ_FBXW4 - DOID:9351 diabetes mellitus diabetes-associated endothelial dysfunction "RT-qPCR, RNA-seq" dysregulated Our work highlights the potential regulatory mechanisms of three crucial circRNAs in diabetes-associated endothelial dysfunction. 1 Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells. hsa_circ_0003250 hsa_circ_MRRF - DOID:9351 diabetes mellitus diabetes-associated endothelial dysfunction "RT-qPCR, RNA-seq" dysregulated Our work highlights the potential regulatory mechanisms of three crucial circRNAs in diabetes-associated endothelial dysfunction. 1 Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells. hsa_circ_0045462 hsa_circ_BPTF - DOID:9351 diabetes mellitus diabetes-associated endothelial dysfunction "RT-qPCR, RNA-seq" dysregulated Our work highlights the potential regulatory mechanisms of three crucial circRNAs in diabetes-associated endothelial dysfunction. 1 Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells. hsa_circ_0064772 hsa_circ_CLASP2 - DOID:9351 diabetes mellitus diabetes-associated endothelial dysfunction "RT-qPCR, RNA-seq" dysregulated Our work highlights the potential regulatory mechanisms of three crucial circRNAs in diabetes-associated endothelial dysfunction. 1 Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells. hsa_circ_0007976 hsa_circ_HIF1A - DOID:9351 diabetes mellitus diabetes-associated endothelial dysfunction "RT-qPCR, RNA-seq" dysregulated Our work highlights the potential regulatory mechanisms of three crucial circRNAs in diabetes-associated endothelial dysfunction. 1 Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells. hsa_circ_0005263 hsa_circ_FNDC3A - DOID:9351 diabetes mellitus diabetes-associated endothelial dysfunction "RT-qPCR, RNA-seq" dysregulated Our work highlights the potential regulatory mechanisms of three crucial circRNAs in diabetes-associated endothelial dysfunction. 1 circHECTD1 facilitates glutaminolysis to promote gastric cancer progression by targeting miR-1256 and activating beta-catenin/c-Myc signaling. - hsa_circ_HECTD1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circHECTD1 is a glutaminolysis-associated circRNA that promotes GC progression. The circHECTD1/miR-1256/USP5 axis. 2 "Circ-ITGA7 sponges miR-3187-3p to upregulate ASXL1, suppressing colorectal cancer proliferation." - hsa_circ_ITGA7 - DOID:9256 colorectal cancer colorectal cancer RNA-seq down-regulated Circ-ITGA7 might suppress CRC proliferation by sponging miR-3187-3p and increasing ASXL1 expression. 4 CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression. - - circRNA_101505 DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray dysregulated "circRNA_101505 could sensitize HCC cells to cisplatin by sponging miR-103, and thereby promoting oxidored-nitro domain-containing protein 1 (NOR1) expression." 1 "Circular RNA circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels via directly sponging miR-103 in Alzheimer disease." hsa_circ_0000950 hsa_circ_AKT1S1 circ_0000950 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR dysregulated "circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels through directly sponging miR-103 in AD." 1 Circ-IGF1R has pro-proliferative and anti-apoptotic effects in HCC by activating the PI3K/AKT pathway. - hsa_circ_IGF1R - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ-IGF1R may be a potential target for the prevention and treatment of HCC. 1 "[Effect of circular RNA hsa_circ_0063772 on proliferation, migration and invasion of oral squamous cell carcinoma cells]." hsa_circ_0063772 hsa_circ_ATXN10 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "High expression of hsa_circ_0063772 can inhibit the proliferation, migration and invasion of OSCC cells." 1 "Circular RNA ABCB10 correlates with advanced clinicopathological features and unfavorable survival, and promotes cell proliferation while reduces cell apoptosis in epithelial ovarian cancer." - hsa_circ_ABCB10 - DOID:2152 ovary epithelial cancer epithelial ovarian cancer RT-qPCR up-regulated "Circ-ABCB10 correlates with advanced clinicopathological features and unfavorable survival, and promotes proliferation, reduces apoptosis and negatively regulated miR-1271, miR-1252 and miR-203 in EOC." 2 Upregulation of circFLNA contributes to laryngeal squamous cell carcinoma migration by circFLNA-miR-486-3p-FLNA axis. - hsa_circ_FLNA - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated Dysregulation of the circFLNA/miR-486-3p/FLNA regulatory pathway contributes to LSCC migration. 1 "Silencing circular RNA circZNF609 restrains growth, migration and invasion by up-regulating microRNA-186-5p in prostate cancer." - hsa_circ_ZNF609 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated circZNF609 restrained the YAP1 and AMPK pathways by up-regulating miR-186-5p. 2 The circular RNA circ-ITCH acts as a tumour suppressor in osteosarcoma via regulating miR-22. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "Circ-ITCH took effects on apoptosis, viability, proliferation, migration and invasion through restraining PTEN/PI3K/AKT and SP-1 pathways via down-regulating miR-22 in MG63 and Saos-2 cells. Highlights Low expression of circ-ITCH is observed in osteosarcoma tissues and cell lines; Overexpression circ-ITCH suppresses miR-22 expression; Circ-ITCH promotes proliferation and represses apoptosis by up-regulating miR-22; Circ-ITCH promotes migration and invasion by up-regulating miR-22; Circ-ITCH activates PTEN/PI3K/AKT and SP-1 pathways by up-regulating miR-22." 2 "circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression." - hsa_circ_MYBL2 - DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated circMYBL2 specifically influences FLT3-ITD AML and regulates FLT3 kinase levels through translational regulation. 1 CircRNA LRP6 promotes the development of osteosarcoma via negatively regulating KLF2 and APC levels. - hsa_circ_LRP6 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circLRP6 was highly expressed in OS and served as an oncogene by binding to LSD1 and EZH2 to inhibit expressions of KLF2 and APC. 2 Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4. - - circRNA_000203 DOID:114 heart disease cardiac hypertrophy RT-qPCR up-regulated circRNA_000203 exacerbates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p leading to enhanced Gata4 levels. 2 A Novel Circular RNA Mediates Pyroptosis of Diabetic Cardiomyopathy by Functioning as a Competing Endogenous RNA. - hsa_circ_CACR - DOID:0050700 cardiomyopathy Diabetic cardiomyopathy RT-qPCR dysregulated CACR might be a novel therapeutic target via the CACR/miR-214-3p/caspase-1 pathway in DCM. 1 Circular RNA circSCAF11 Accelerates the Glioma Tumorigenesis through the miR-421/SP1/VEGFA Axis. - hsa_circ_SCAF11 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated Circular RNA circSCAF11 Accelerates the Glioma Tumorigenesis through the miR-421/SP1/VEGFA Axis. 2 CircPAN3 contributes to drug resistance in acute myeloid leukemia through regulation of autophagy. - hsa_circ_PAN3 circPAN3 DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, RNA-seq" dysregulated circPAN3 might be a potential target for treatment of drug-resistance AML. 2 Expression of circZNF609 is Down-Regulated in Colorectal Cancer Tissue and Promotes Apoptosis in Colorectal Cancer Cells by Upregulating p53. - hsa_circ_ZNF609 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated Expression of circZNF609 was down-regulated in colorectal cancer tissue and promoted apoptosis in colorectal cancer cells in vitro by upregulating p53. 3 Circ_0136474 and MMP-13 suppressed cell proliferation by competitive binding to miR-127-5p in osteoarthritis. hsa_circ_0136474 hsa_circ_ASH2L circ_0136474 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Circ_0136474 and MMP-13 suppressed cell proliferation, while enhanced cell apoptosis by competitive binding to miR-127-5p in OA." 2 Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis. hsa_circ_0000977 hsa_circ_NOL10 circ_0000977 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated circ_0000977/miR-153 axis modulates HIF1A-mediated immune escape of PC cells through miR-153 downstream targets HIF1A and ADAM10. 2 Circular RNA ITCH downregulates GLUT1 and suppresses glucose uptake in melanoma to inhibit cancer cell proliferation. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:1909 melanoma melanoma RT-qPCR down-regulated ITCH may downregulate GLUT1 and suppresses glucose uptake in melanoma to inhibit cancer cell proliferation. 2 circKDM4C suppresses tumor progression and attenuates doxorubicin resistance by regulating miR-548p/PBLD axis in breast cancer. - hsa_circ_KDM4C - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "circKDM4C might have considerable potential as a prognostic biomarker in breast cancer, and support the notion that therapeutic targeting of circKDM4C/miR-548p/PBLD axis may be a promising treatment approach for breast cancer patients." 1 Overexpression of circular RNA circ-CDC45 facilitates glioma cell progression by sponging miR-516b and miR-527 and predicts an adverse prognosis. - hsa_circ_CDC45 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated circ-CDC45 sponged and regulated the expression of miR-516b and miR-527 to promote cell growth and invasion. 1 Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression. - hsa_circ_ZFR - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circZFR acted as a sponge to absorb microRNA-101-3p (miR-101-3p) and promoted cullin 4B (CUL4B) expression. 3 Circular RNA PRKCI promotes glioma cell progression by inhibiting microRNA-545. - hsa_circ_PRKCI - DOID:0060108 brain glioma glioma RT-qPCR up-regulated circPRKCI promotes human glioma cell progression possibly by inhibiting miR-545. 1 Circular RNA profile identifies circOSBPL10 as an oncogenic factor and prognostic marker in gastric cancer. - hsa_circ_OSBPL10 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated circOSBPL10 regulates biological functions in GC cells via a circOSBPL10-miR-136-5p-WNT2 axis. 1 Hsa_circ_0003998 may be used as a new biomarker for the diagnosis and prognosis of hepatocellular carcinoma. hsa_circ_0003998 hsa_circ_ARFGEF2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated hsa_circ_0003998 may be used as a novel potential biomarker for the diagnosis and prognosis of HCC patients. 3 Circular RNA hsa_circRNA_102958 promotes tumorigenesis of colorectal cancer via miR-585/CDC25B axis. - - hsa_circRNA_102958 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated hsa_circRNA_102958 promoted CDC25B expression through inhibiting miR-585 in CRC. 1 Circular RNA MYLK promotes hepatocellular carcinoma progression by increasing Rab23 expression by sponging miR-362-3p. - hsa_circ_MYLK - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circMYLK promotes the occurrence and development of HCC by regulating the miR-362-3p/Rab23 axis. 2 CircABCC2 Regulates Hepatocellular Cancer Progression by Decoying MiR-665. - hsa_circ_ABCC2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated circABCC2 regulates ABCC2 expression and HCC progression by sponging miR-665. 1 circGFRA1 Promotes Ovarian Cancer Progression By Sponging miR-449a. - hsa_circ_GFRA1 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated circGFRA1 regulated GFRA1 expression and ovarian cancer progression by sponging miR-449a. 1 Altered expression of circular RNA in primary Sjogren syndrome. - - hsa_circRNA_001264 DOID:12894 Sjogren syndrome sjogren syndrome microarray dysregulated "hsa_circRNA_001264, hsa_circRNA_104121, and hsa_circRNA_045355 might be biomarkers for pSS." 1 Altered expression of circular RNA in primary Sjogren syndrome. - - hsa_circRNA_104121 DOID:12894 Sjogren syndrome sjogren syndrome microarray dysregulated "hsa_circRNA_001264, hsa_circRNA_104121, and hsa_circRNA_045355 might be biomarkers for pSS." 1 Altered expression of circular RNA in primary Sjogren syndrome. - - hsa_circRNA_045355 DOID:12894 Sjogren syndrome sjogren syndrome microarray dysregulated "hsa_circRNA_001264, hsa_circRNA_104121, and hsa_circRNA_045355 might be biomarkers for pSS." 1 Altered expression of circular RNA in primary Sjogren syndrome. - - hsa_circRNA_103461 DOID:12894 Sjogren syndrome sjogren syndrome microarray dysregulated "hsa_circRNA_001264, hsa_circRNA_104121, and hsa_circRNA_045355 might be biomarkers for pSS." 1 Altered expression of circular RNA in primary Sjogren syndrome. - - hsa_circRNA_105034 DOID:12894 Sjogren syndrome sjogren syndrome microarray dysregulated "hsa_circRNA_001264, hsa_circRNA_104121, and hsa_circRNA_045355 might be biomarkers for pSS." 1 Hsa_circ_101882 promotes migration and invasion of gastric cancer cells by regulating EMT. - - hsa_circ_101882 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated hsa_circ_101882 is considered a metastasis promoter by activating EMT and may serve as a critical oncogene and potential new biomarker in GC. 1 Role of CircRNAs_100395 in Proliferation and Metastases of Liver Cancer. - - circRNAs_100395 DOID:3571 liver cancer liver cancer RT-qPCR down-regulated "upregulation of circ_100395 in liver cancer cells inhibited cell proliferation, induced apoptosis, then silenced the EMT pathway and reduced migration and invasion abilities, while this anti-tumor effect was significantly reversed by the downstream target, miR-1228." 1 "CircHIPK3 is decreased in preeclampsia and affects migration, invasion, proliferation, and tube formation of human trophoblast cells." hsa_circ_0000284 hsa_circ_HIPK3 - DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated circHIPK3 may contribute to the development of preeclampsia by leading to the aberrant biological behavior of trophoblast cells. 1 circCPA4 acts as a prognostic factor and regulates the proliferation and metastasis of glioma. - hsa_circ_CPA4 - DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" up-regulated The circCPA4/let-7/CPA4 axis regulates glioma progression by ceRNA mechanism. 3 Down-regulation of hsa_circ_0092125 is related to the occurrence and development of oral squamous cell carcinoma. hsa_circ_0092125 hsa_circ_G6PD - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated down-regulated expression of hsa_circ_0092125 might serve as a biomarker of the OSCC prognosis. 1 Circular RNA MYLK serves as an oncogene to promote cancer progression via microRNA-195/cyclin D1 axis in laryngeal squamous cell carcinoma. - hsa_circ_MYLK - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated circMYLK/miR-195/cyclin D1 regulatory axis could affect the proliferation and cell cycle progression of LSCC cells. 1 Down-regulated circPAPPA suppresses the proliferation and invasion of trophoblast cells via the miR-384/STAT3 pathway. hsa_circ_0088227 hsa_circ_PAPPA - DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "down-regulation of circPAPPA facilitates the onset and development of PE by suppressing trophoblast cells, with involvement of the miR-384/STAT3 signaling pathway." 2 Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma. hsa_circ_0007334 hsa_circ_MBOAT2 hsa_circRNA_0007334 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RNA-seq up-regulated hsa_circRNA_0007334 was significantly upregulated and may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 (MMP7) and collagen type I alpha 1 chain (COL1A1) by the competitive adsorption of hsa-miR-144-3p and hsa-miR-577 to enhance the expression and functions of MMP7 and COL1A1 in PDAC. 1 Circulating plasma circular RNAs as novel diagnostic biomarkers for congenital heart disease in children. - - hsa_circRNA_004183 DOID:1682 congenital heart disease congenital heart disease "RT-qPCR, RNA-seq" down-regulated We identified three circRNAs under-expressed in plasma from children with CHD. These circRNAs may be crucial in the development of CHD and may serve as novel non-invasive biomarkers for the diagnosis of CHD in children. 1 Circulating plasma circular RNAs as novel diagnostic biomarkers for congenital heart disease in children. - - hsa_circRNA_079265 DOID:1682 congenital heart disease congenital heart disease "RT-qPCR, RNA-seq" down-regulated We identified three circRNAs under-expressed in plasma from children with CHD. These circRNAs may be crucial in the development of CHD and may serve as novel non-invasive biomarkers for the diagnosis of CHD in children. 1 Circulating plasma circular RNAs as novel diagnostic biomarkers for congenital heart disease in children. - - hsa_circRNA_105039 DOID:1682 congenital heart disease congenital heart disease "RT-qPCR, RNA-seq" down-regulated We identified three circRNAs under-expressed in plasma from children with CHD. These circRNAs may be crucial in the development of CHD and may serve as novel non-invasive biomarkers for the diagnosis of CHD in children. 1 Identification of circular RNAs hsa_circ_0044235 and hsa_circ_0068367 as novel biomarkers for systemic lupus erythematosus. hsa_circ_0044235 hsa_circ_CDC27 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, RNA-seq" down-regulated the levels of hsa_circ_0044235 and hsa_circ_0068367 in PBMC have potential as biomarkers for SLE diagnosis. 2 Identification of circular RNAs hsa_circ_0044235 and hsa_circ_0068367 as novel biomarkers for systemic lupus erythematosus. hsa_circ_0068367 hsa_circ_VPS8 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, RNA-seq" down-regulated the levels of hsa_circ_0044235 and hsa_circ_0068367 in PBMC have potential as biomarkers for SLE diagnosis. 1 Hsa_circ_0065149 is an Indicator for Early Gastric Cancer Screening and Prognosis Prediction. hsa_circ_0065149 hsa_circ_SETD2 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "In conclusion, our results suggested that downregulated expression of hsa_circ_0065149 is an indicator for prognosis prediction and biomarker for early gastric cancer screening." 1 Silencing circular ANRIL protects HK-2 cells from lipopolysaccharide-induced inflammatory injury through up-regulating microRNA-9. - hsa_circ_ANRIL cANRIL DOID:557 kidney disease chronic kidney disease RT-qPCR dysregulated "silencing cANRIL hindered NF-¦ĘB and JNK/p38 pathways by positively regulating miR-9, thereby protecting HK-2 cells from LPS-induced injury." 1 Microarray Analysis of circRNA Expression Pattern in Corneal Neovascularization. - hsa_circ_ZFP609 - DOID:11382 corneal neovascularization corneal neovascularization RNA-seq dysregulated This study suggests that circRNAs are involved in the pathogenesis of corneal neovascularization. cZFP609 and cKifap3 may serve as promising targets for the treatment of corneal neovascularization. 1 Microarray Analysis of circRNA Expression Pattern in Corneal Neovascularization. - hsa_circ_Kifap3 - DOID:11382 corneal neovascularization corneal neovascularization RNA-seq dysregulated This study suggests that circRNAs are involved in the pathogenesis of corneal neovascularization. cZFP609 and cKifap3 may serve as promising targets for the treatment of corneal neovascularization. 1 CircRNA CBL11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer. - hsa_circ_CBL11 circRNA CBL.11 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "After carbon ion irradiation, circRNA CBL.11 was increased in CRC cells and could function as a competing endogenous RNA (ceRNA) to regulate YWHAE expression by sponging miR-6778-5p, resulting in regulation the proliferation of CRC cells." 1 Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/vimentin axis. - hsa_circ_NHSL1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated CircNHSL1 promotes gastric cancer progression through miR-1306-3p/SIX1/Vimentin axis. 2 Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2. - hsa_circ_HIPK2 - DOID:1596 depressive disorder depression RT-qPCR dysregulated "Our study illustrates the involvement of the gut microbiota-circHIPK2-astrocyte axis in depression, providing translational evidence that transplantation of the gut microbiota from NLRP3 KO mice may serve as a novel therapeutic strategy for depression." 1 Downregulation of hsa_circ_0007534 restricts the proliferation and invasion of cervical cancer through regulating miR-498/BMI-1 signaling. hsa_circ_0007534 hsa_circ_DDX42 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated downregulation of hsa_circ_0007534 represses the proliferation and invasion of cervical cancer through regulating the miR-498/BMI-1 axis. 1 Regulatory network of two circRNAs and an miRNA with their targeted genes under astilbin treatment in pulmonary fibrosis. - - circRNA-394 DOID:3770 pulmonary fibrosis pulmonary fibrosis "RT-qPCR, RNA-seq" up-regulated "Four differentially expressed circRNAs (circRNA-662, 949, 394 and 986) were tested to validate the RNA sequencing data, and their targeted microRNAs and genes were analysed by qRT-PCR, Western blot, Pearson correlation coefficient, a dual-luciferase reporter system and anti-AGO(2) RNA immunoprecipitation. " 1 Regulatory network of two circRNAs and an miRNA with their targeted genes under astilbin treatment in pulmonary fibrosis. - - circRNA-662 DOID:3770 pulmonary fibrosis pulmonary fibrosis "RT-qPCR, RNA-seq" up-regulated "Four differentially expressed circRNAs (circRNA-662, 949, 394 and 986) were tested to validate the RNA sequencing data, and their targeted microRNAs and genes were analysed by qRT-PCR, Western blot, Pearson correlation coefficient, a dual-luciferase reporter system and anti-AGO(3) RNA immunoprecipitation." 1 Regulatory network of two circRNAs and an miRNA with their targeted genes under astilbin treatment in pulmonary fibrosis. - - circRNA-949 DOID:3770 pulmonary fibrosis pulmonary fibrosis "RT-qPCR, RNA-seq" up-regulated "Four differentially expressed circRNAs (circRNA-662, 949, 394 and 986) were tested to validate the RNA sequencing data, and their targeted microRNAs and genes were analysed by qRT-PCR, Western blot, Pearson correlation coefficient, a dual-luciferase reporter system and anti-AGO(4) RNA immunoprecipitation." 1 Regulatory network of two circRNAs and an miRNA with their targeted genes under astilbin treatment in pulmonary fibrosis. - - circRNA-986 DOID:3770 pulmonary fibrosis pulmonary fibrosis "RT-qPCR, RNA-seq" up-regulated "Four differentially expressed circRNAs (circRNA-662, 949, 394 and 986) were tested to validate the RNA sequencing data, and their targeted microRNAs and genes were analysed by qRT-PCR, Western blot, Pearson correlation coefficient, a dual-luciferase reporter system and anti-AGO(5) RNA immunoprecipitation." 1 circPIP5K1A serves as a competitive endogenous RNA contributing to ovarian cancer progression via regulation of miR-661/IGFBP5 signaling. - hsa_circ_PIP5K1A circPIP5K1A DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated circPIP5K1A contributed to ovarian cancer progression via targeting the miR-661/IGFBP5 axis. 2 ERalpha-mediated alterations in circ_0023642 and miR-490-5p signaling suppress bladder cancer invasion. hsa_circ_0023642 hsa_circ_UVRAG circ_0023642 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated ERalpha/circ_0023642/miR-490-5p/EGFR signaling pathway suppressed BCa progression. 2 "Plasma circular RNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma: A large-scale, multicenter study." hsa_circ_0000976 hsa_circ_HPCAL1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" dysregulated "In summary, by a microarray screening and qRT-PCR in a multicenter study, we identified a plasma circRNA panel (CircPanel) containing three circRNAs (hsa_circ_0000976, hsa_circ_0007750 and hsa_circ_0139897) that detected HCC." 1 "Plasma circular RNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma: A large-scale, multicenter study." hsa_circ_0007750 hsa_circ_RABGGTA - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" dysregulated "In summary, by a microarray screening and qRT-PCR in a multicenter study, we identified a plasma circRNA panel (CircPanel) containing three circRNAs (hsa_circ_0000976, hsa_circ_0007750 and hsa_circ_0139897) that detected HCC." 1 "Plasma circular RNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma: A large-scale, multicenter study." hsa_circ_0139897 hsa_circ_MTM1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" dysregulated "In summary, by a microarray screening and qRT-PCR in a multicenter study, we identified a plasma circRNA panel (CircPanel) containing three circRNAs (hsa_circ_0000976, hsa_circ_0007750 and hsa_circ_0139897) that detected HCC." 1 The circular RNA hsa-circ-0072309 plays anti-tumour roles by sponging miR-100 through the deactivation of PI3K/AKT and mTOR pathways in the renal carcinoma cell lines. hsa_circ_0072309 hsa_circ_LIFR - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated The circular RNA hsa-circ-0072309 plays anti-tumour roles by sponging miR-100 through the deactivation of PI3K/AKT and mTOR pathways in the renal carcinoma cell lines. 2 Circular RNA CircMTO1 Inhibits Proliferation of Glioblastoma Cells via miR-92/WWOX Signaling Pathway. - hsa_circ_MTO1 - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated circMTO1 inhibits the proliferation of glioblastoma cells via the miR-92/WWOX signaling pathway. 1 A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1. - hsa_circ_AKT3 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "Circ-AKT3 encodes a 174 amino acid (aa) novel protein AKT3-174aa. AKT3-174aa competitively interacts with phosphorylated PDK1, reduces AKT-thr308 phosphorylation, and plays a negative regulatory role in modulating the PI3K/AKT signal intensity." 2 A circRNA signature predicts postoperative recurrence in stage II/III colon cancer. hsa_circ_0122319 - - DOID:219 colon cancer colon cancer RNA-seq up-regulated "Three circRNA (hsa_circ_0122319, hsa_circ_0079480, and hsa_circ_0087391) were significantly overexpressed in the recurrent samples and in the colon cancer cells." 1 A circRNA signature predicts postoperative recurrence in stage II/III colon cancer. hsa_circ_0087391 hsa_circ_AGTPBP1 - DOID:219 colon cancer colon cancer RNA-seq up-regulated "Three circRNA (hsa_circ_0122319, hsa_circ_0079480, and hsa_circ_0087391) were significantly overexpressed in the recurrent samples and in the colon cancer cells." 1 A circRNA signature predicts postoperative recurrence in stage II/III colon cancer. hsa_circ_0079480 hsa_circ_ISPD - DOID:219 colon cancer colon cancer RNA-seq up-regulated "Three circRNA (hsa_circ_0122319, hsa_circ_0079480, and hsa_circ_0087391) were significantly overexpressed in the recurrent samples and in the colon cancer cells." 1 Down-Regulation of Circular RNA_000926 Attenuates Renal Cell Carcinoma Progression through miRNA-411-Dependent CDH2 Inhibition. hsa_circ_0001022 hsa_circ_ACTR2 circular RNA_000926 DOID:4451 renal carcinoma renal carcinoma "RT-qPCR, RNA-seq" up-regulated Down-regulation of circ_000926 exerts an inhibitory effect on RCC progression through miR-411-dependent CDH2 inhibition. 1 Hsa_circ_0005075 promotes the proliferation and invasion of colorectal cancer cells. hsa_circ_0005075 hsa_circ_EIF4G3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Hsa_circ_0005075 promotes the proliferation and invasion of colorectal cancer cells. 2 Circular RNA 4099 aggravates hydrogen peroxide-induced injury by down-regulating microRNA-706 in L02 cells. - - circular RNA 4099 DOID:2237 hepatitis hepatitis RT-qPCR up-regulated circRNA-4099 aggravated H2O2-induced injury by inhibiting miR-706 through triggering keap1/Nrf2 and p38MAPK in the L02 cells. 1 Circular RNA circ-PRMT5 facilitates non-small cell lung cancer proliferation through upregulating EZH2 via sponging miR-377/382/498. - hsa_circ_PRMT5 circPRMT5 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ-PRMT5 is an oncogenic circRNA in NSCLC that can promote the growth of NSCLC via regulation of miR-377/382/498-EZH2 axis. 3 Circular RNA Cdr1as Upregulates SCAI to Suppress Cisplatin Resistance in Ovarian Cancer via miR-1270 Suppression. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:2394 ovarian cancer ovarian cancer microarray dysregulated Cdr1as sensitizes ovarian cancer to cisplatin by regulating the miR-1270/SCAI signaling pathway. 3 The Role of Circular RNA CDR1as/ciRS-7 in Regulating Tumor Microenvironment: A Pan-Cancer Analysis. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:162 cancer cancer RNA-seq up-regulated CDR1as may play a specific role in immune and stromal cell infiltration in tumor tissue. 1 Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence. - hsa_circ_ZKSCAN1 circ-ZKSCAN1 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated Circ-ZKSCAN1 acts as a tumor suppressor via a novel circ-ZKSCAN1/miR-1178-3p/p21 axis. 1 Silencing circular RNA circ_0010729 protects human cardiomyocytes from oxygen-glucose deprivation-induced injury by up-regulating microRNA-145-5p. hsa_circ_0010729 hsa_circ_HSPG2 circ_0010729 DOID:1287 cardiovascular system disease myocardial ischemia RT-qPCR dysregulated silencing circ_0010729 activated mTOR and MEK/ERK pathways by up-regulating miR-145-5p. 1 RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma. hsa_circ_0077837 hsa_circ_EPB41L2 - DOID:1324 lung cancer lung cancer RNA-seq dysregulated "Moreover, ROC analyses demonstrate that hsa_circ_0077837 and hsa_circ_0001821 have the diagnostic potential for NSCLC patients, while hsa_circ_0001073 and hsa_circ_0001495 could act as biomarkers for NSCLC pathological subtyping." 2 RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma. hsa_circ_0001821 hsa_circ_TCONS_00015354 - DOID:1324 lung cancer lung cancer RNA-seq dysregulated "Moreover, ROC analyses demonstrate that hsa_circ_0077837 and hsa_circ_0001821 have the diagnostic potential for NSCLC patients, while hsa_circ_0001073 and hsa_circ_0001495 could act as biomarkers for NSCLC pathological subtyping." 1 RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma. hsa_circ_0001073 hsa_circ_ACVR2A - DOID:1324 lung cancer lung cancer RNA-seq dysregulated "Moreover, ROC analyses demonstrate that hsa_circ_0077837 and hsa_circ_0001821 have the diagnostic potential for NSCLC patients, while hsa_circ_0001073 and hsa_circ_0001495 could act as biomarkers for NSCLC pathological subtyping." 2 RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma. hsa_circ_0001495 hsa_circ_CCNB1 - DOID:1324 lung cancer lung cancer RNA-seq dysregulated "Moreover, ROC analyses demonstrate that hsa_circ_0077837 and hsa_circ_0001821 have the diagnostic potential for NSCLC patients, while hsa_circ_0001073 and hsa_circ_0001495 could act as biomarkers for NSCLC pathological subtyping." 1 Overexpressed circPVT1 in oral squamous cell carcinoma promotes proliferation by serving as a miRNA sponge. - hsa_circ_PVT1 circPVT1 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated CircPVT1 functioned as competing endogenous RNA (ceRNA) to increase the STAT3 level and cell proliferation through sponging miR_125b. 2 Construction of a circular RNA-microRNA-messengerRNA regulatory network in stomach adenocarcinoma. hsa_circ_0018004 hsa_circ_PDSS1 - DOID:3717 gastric adenocarcinoma stomach adenocarcinoma RT-qPCR down-regulated The expression of hsa_circ_0018004 was lower in STAD tissues than in ANGM. 1 CircRNA_100876 promote proliferation and metastasis of breast cancer cells through adsorbing microRNA-361-3p in a sponge form. - - circRNA_100876 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circRNA_100876 is able to promote BC metastasis as well as proliferative capacity by modulating microRNA-361-3p expression. 1 Circular RNA expression profiling identifies hsa_circ_0011460 as a novel molecule in severe preeclampsia. hsa_circ_0011460 hsa_circ_PGT - DOID:13129 severe pre-eclampsia severe preeclampsia "RT-qPCR, RNA-seq" up-regulated we speculated that hsa_circ_0011460 may participate in the occurrence and development of SPE by anchoring the protein of PGT. 1 "Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia." - hsa_circ_DENND4C - DOID:1612 breast cancer breast cancer RNA-seq up-regulated "circDENND4C silence suppresses glycolysis, migration and invasion in breast cancer cells under hypoxia by increasing miR-200b and miR-200c." 2 Circular RNA ciRS-7 inhibits autophagy of ESCC cells by functioning as miR-1299 sponge to target EGFR signaling. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated circular RNA ciRS-7 inhibits autophagy of ESCC cells by functioning as miR-1299 sponge to target EGFR signaling. 4 Hsa_circ_0035483 sponges hsa-miR-335 to promote the gemcitabine-resistance of human renal cancer cells by autophagy regulation. hsa_circ_0035483 hsa_circ_CCNB2 - DOID:4451 renal carcinoma renal carcinoma RNA-seq dysregulated hsa_circ_0035483 promotes autophagy and tumor growth and enhances gemcitabine resistance in RCC by regulating hsa-miR-335/CCNB1. 2 Circular RNA circ-PITX1 promotes the progression of glioblastoma by acting as a competing endogenous RNA to regulate miR-379-5p/MAP3K2 axis. - hsa_circ_PITX1 circ-PITX1 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated circ-PITX1 exerted as a competing endogenous RNA (ceRNA) in glioblastoma by sponging miR-379-5p to elevate MAP3K2 expression. 3 Circular RNA expression profile of liver tissues in an EtOH-induced mouse model of alcoholic hepatitis. - - mm9_ circ_018725 DOID:12351 alcoholic hepatitis alcoholic hepatitis "RT-qPCR, RNA-seq" dysregulated knockdown of mm9_ circ_018725 could inhibit hepatocyte apoptosis induced by EtOH in vitro. 1 Circular RNA expression and circPTPRM promotes proliferation and migration in hepatocellular carcinoma. - hsa_circ_PTPRM circPTPRM DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq up-regulated CircPTPRM was significantly upregulated in HCC and may function during the tumorigenesis and metastasis of HCC. 1 Fucoidan affects oral squamous cell carcinoma cell functions in vitro by regulating FLNA-derived circular RNA. - hsa_circ_FLNA - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated fucoidan might be considered as a potential natural drug in the treatment of OSCC patients by targeting circFLNA. 1 "Circular RNA hsa_circ_0023404 promotes proliferation, migration and invasion in non-small cell lung cancer by regulating miR-217/ZEB1 axis." hsa_circ_0023404 hsa_circ_RNF121 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "hsa_circ_0023404 promotes the proliferation, migration and invasion of NSCLC cells by regulating miR-217/ZEB1 axis." 2 "CircLMNB1 promotes colorectal cancer by regulating cell proliferation, apoptosis and epithelial-mesenchymal transition." - hsa_circ_LMNB1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Our findings revealed that blocking of circLMNB1 could inhibit CRC development, and help to explain the underlying mechanism by which circLMNB1 knockdown inhibits the metastasis of CRC." 2 The role of circular RNA hsa_circ_0085616 in proliferation and migration of hepatocellular carcinoma cells. hsa_circ_0085616 hsa_circ_ASAP1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Upregulation or downregulation of hsa_circ_0085616 expression could strengthen or weaken the proliferative ability of HCC cells in vitro. 3 CircPOMT1 and circMCM3AP inhibit osteogenic differentiation of human adipose-derived stem cells by targeting miR-6881-3p. - hsa_circ_POMT1 circPOMT1 DOID:0080001 bone disease osteogenic differentiation RNA-seq down-regulated circPOMT1 and circMCM3AP might influence the osteogenic differentiation of hASCs by targeting hsa-miR-6881-3p via BMPs signaling pathway. 1 CircPOMT1 and circMCM3AP inhibit osteogenic differentiation of human adipose-derived stem cells by targeting miR-6881-3p. - hsa_circ_MCM3AP - DOID:0080001 bone disease osteogenic differentiation RNA-seq down-regulated circPOMT1 and circMCM3AP might influence the osteogenic differentiation of hASCs by targeting hsa-miR-6881-4p via BMPs signaling pathway. 1 Circ_0039569 promotes renal cell carcinoma growth and metastasis by regulating miR-34a-5p/CCL22. - - circ_0039569 DOID:4451 renal carcinoma renal carcinoma "RT-qPCR, RNA-seq" up-regulated Circ_0039569 promotes renal cell carcinoma growth and metastasis by regulating miR-34a-5p/CCL22. 1 Circular RNA circ-ADD3 inhibits hepatocellular carcinoma metastasis through facilitating EZH2 degradation via CDK1-mediated ubiquitination. - hsa_circ_ADD3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray down-regulated circ-ADD3 in inhibiting HCC metastasis through regulation of EZH2 stability. 1 Circ-0000284 arouses malignant phenotype of cholangiocarcinoma cells and regulates the biological functions of peripheral cells through cellular communication. hsa_circ_0000284 hsa_circ_HIPK3 circ-0000284 DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR up-regulated "on the one hand circ-0000284 functions as a competitive endogenous RNA to promote cholangiocarcinoma progression, and on the other hand, circ-0000284 can be directly transferred from cholangiocarcinoma cells to surrounding normal cells via exosomes." 2 CircRNA expression profiles and function prediction in peripheral blood mononuclear cells of patients with acute ischemic stroke. - - hsa_circ:chr1:95609447_95616975 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, RNA-seq" up-regulated "Bioinformatics analyses showed that these differentially expressed circRNAs were highly conserved, as well as eight circRNAs that were confirmed by qRT-PCR containing binding sites to multiple microRNAs." 1 CircRNA expression profiles and function prediction in peripheral blood mononuclear cells of patients with acute ischemic stroke. - - hsa_circ:chr6:41250133_41250489 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, RNA-seq" up-regulated "Bioinformatics analyses showed that these differentially expressed circRNAs were highly conserved, as well as eight circRNAs that were confirmed by qRT-PCR containing binding sites to multiple microRNAs." 1 CircRNA expression profiles and function prediction in peripheral blood mononuclear cells of patients with acute ischemic stroke. - - hsa_circ:chr12:94613792_94621011 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, RNA-seq" up-regulated "Bioinformatics analyses showed that these differentially expressed circRNAs were highly conserved, as well as eight circRNAs that were confirmed by qRT-PCR containing binding sites to multiple microRNAs." 1 CircRNA expression profiles and function prediction in peripheral blood mononuclear cells of patients with acute ischemic stroke. - - hsa_circ:chr15:55640530_55640923 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, RNA-seq" up-regulated "Bioinformatics analyses showed that these differentially expressed circRNAs were highly conserved, as well as eight circRNAs that were confirmed by qRT-PCR containing binding sites to multiple microRNAs." 1 CircRNA expression profiles and function prediction in peripheral blood mononuclear cells of patients with acute ischemic stroke. - - hsa_circ:chr9:80869752_80879232 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, RNA-seq" down-regulated "Bioinformatics analyses showed that these differentially expressed circRNAs were highly conserved, as well as eight circRNAs that were confirmed by qRT-PCR containing binding sites to multiple microRNAs." 1 CircRNA expression profiles and function prediction in peripheral blood mononuclear cells of patients with acute ischemic stroke. - - hsa_circ:chr1:58971728_59004978 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, RNA-seq" down-regulated "Bioinformatics analyses showed that these differentially expressed circRNAs were highly conserved, as well as eight circRNAs that were confirmed by qRT-PCR containing binding sites to multiple microRNAs." 1 CircRNA expression profiles and function prediction in peripheral blood mononuclear cells of patients with acute ischemic stroke. - - hsa_circ:chr12:10539502_10546466 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, RNA-seq" down-regulated "Bioinformatics analyses showed that these differentially expressed circRNAs were highly conserved, as well as eight circRNAs that were confirmed by qRT-PCR containing binding sites to multiple microRNAs." 1 CircRNA expression profiles and function prediction in peripheral blood mononuclear cells of patients with acute ischemic stroke. - - hsa_circ:chr12:69044180_69048032 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, RNA-seq" down-regulated "Bioinformatics analyses showed that these differentially expressed circRNAs were highly conserved, as well as eight circRNAs that were confirmed by qRT-PCR containing binding sites to multiple microRNAs." 1 Screening for Differentially Expressed Circular RNAs in the Cartilage of Osteoarthritis Patients for Their Diagnostic Value. - - hsa_circ_0020014_CBC1 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" down-regulated "Five differentially expressed circRNAs were selected for further qRT-PCR verification, including four upregulated (hsa_circ_0057421_CBC1, hsa_circ_0020014_CBC1, hsa_ circ_0032131_CBC1, and hsa_circ_00134111_CBC1) and one downregulated circRNA (hsa_circ_0094742_CBC1) for validation in five pairs of chondrocyte samples. It was shown that hsa_circ_0032131_CBC1 is highly consistent in microarray analysis and qRT-PCR verification, which demonstrated the high reliability of the chip analysis data." 1 Screening for Differentially Expressed Circular RNAs in the Cartilage of Osteoarthritis Patients for Their Diagnostic Value. - - hsa_circ_0032131_CBC1 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" up-regulated "Five differentially expressed circRNAs were selected for further qRT-PCR verification, including four upregulated (hsa_circ_0057421_CBC1, hsa_circ_0020014_CBC1, hsa_ circ_0032131_CBC1, and hsa_circ_00134111_CBC1) and one downregulated circRNA (hsa_circ_0094742_CBC1) for validation in five pairs of chondrocyte samples. It was shown that hsa_circ_0032131_CBC2 is highly consistent in microarray analysis and qRT-PCR verification, which demonstrated the high reliability of the chip analysis data." 1 Screening for Differentially Expressed Circular RNAs in the Cartilage of Osteoarthritis Patients for Their Diagnostic Value. - - hsa_circ_0057421_CBC1 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" up-regulated "Five differentially expressed circRNAs were selected for further qRT-PCR verification, including four upregulated (hsa_circ_0057421_CBC1, hsa_circ_0020014_CBC1, hsa_ circ_0032131_CBC1, and hsa_circ_00134111_CBC1) and one downregulated circRNA (hsa_circ_0094742_CBC1) for validation in five pairs of chondrocyte samples. It was shown that hsa_circ_0032131_CBC3 is highly consistent in microarray analysis and qRT-PCR verification, which demonstrated the high reliability of the chip analysis data." 1 Screening for Differentially Expressed Circular RNAs in the Cartilage of Osteoarthritis Patients for Their Diagnostic Value. - - hsa_circ_0094742_CBC1 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" down-regulated "Five differentially expressed circRNAs were selected for further qRT-PCR verification, including four upregulated (hsa_circ_0057421_CBC1, hsa_circ_0020014_CBC1, hsa_ circ_0032131_CBC1, and hsa_circ_00134111_CBC1) and one downregulated circRNA (hsa_circ_0094742_CBC1) for validation in five pairs of chondrocyte samples. It was shown that hsa_circ_0032131_CBC4 is highly consistent in microarray analysis and qRT-PCR verification, which demonstrated the high reliability of the chip analysis data." 1 Screening for Differentially Expressed Circular RNAs in the Cartilage of Osteoarthritis Patients for Their Diagnostic Value. - - hsa_circ_0134111_CBC1 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" up-regulated "Five differentially expressed circRNAs were selected for further qRT-PCR verification, including four upregulated (hsa_circ_0057421_CBC1, hsa_circ_0020014_CBC1, hsa_ circ_0032131_CBC1, and hsa_circ_00134111_CBC1) and one downregulated circRNA (hsa_circ_0094742_CBC1) for validation in five pairs of chondrocyte samples. It was shown that hsa_circ_0032131_CBC5 is highly consistent in microarray analysis and qRT-PCR verification, which demonstrated the high reliability of the chip analysis data." 1 CircFOXO3 promotes glioblastoma progression by acting as a competing endogenous RNA for NFAT5. - hsa_circ_FOXO3 - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated tumor inhibition by circFOXO3 downregulation could be reversed by miR-138-5p/miR-432-5p inhibitors in GBM cells. 1 High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma. hsa_circ_0088364 hsa_circ_MRRF - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" dysregulated "In conclusion, in this study, we identified a population of circRNAs differentially expressed in NC-treated and NC-untreated HCC xenografts in nude mice tissues by high-throughput sequencing analysis and verified the expression of hsa_circ_0088364 and hsa_circ_0090049 by RT-qPCR." 2 High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma. hsa_circ_0090049 hsa_circ_MBTPS2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" dysregulated "In conclusion, in this study, we identified a population of circRNAs differentially expressed in NC-treated and NC-untreated HCC xenografts in nude mice tissues by high-throughput sequencing analysis and verified the expression of hsa_circ_0088364 and hsa_circ_0090049 by RT-qPCR." 2 A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability. - hsa_circ_MMP9 circ-MMP9 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated circular matrix metalloproteinase 9 acts as a metastasis-promoting gene in oral squamous cell carcinoma through regulating the messenger RNA stability of its parental gene. 1 circPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma. - hsa_circ_PTN circPTN DOID:0060108 brain glioma glioma RT-qPCR up-regulated circPTN is an oncogenic factor that acts by sponging miR-145-5p/miR-330-5p in glioma. 3 CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain. - rno_circ_ANKS1A - DOID:936 brain disease neuropathic pain "RT-qPCR, RNA-seq" up-regulated circAnks1a and VEGFB are regulators of neuropathic pain. 1 Homo Sapiens Circular RNA 0079993 (hsa_circ_0079993) of the POLR2J4 Gene Acts as an Oncogene in Colorectal Cancer Through the microRNA-203a-3p1 and CREB1 Axis. hsa_circ_0079993 hsa_circ_POLR2J4 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated hsa_circ_0079993 acts as an oncogene in CRC through the miRNA-203a-3p.1/CREB1 axis. 1 "FBXW7 circular RNA regulates proliferation, migration and invasion of colorectal carcinoma through NEK2, mTOR, and PTEN signaling pathways in vitro and in vivo." - hsa_circ_FBXW7 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "circ-FBXW7 plays a major role in controlling the progression of CRC through NEK2, mTOR, and PTEN signaling pathways and may be a potential therapeutic target for CRC treatment." 3 Downregulation of circular RNA circ-LDLRAD3 suppresses pancreatic cancer progression through miR-137-3p/PTN axis. - hsa_circ_LDLRAD3 - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "knockdown of circ-LDLRAD3 repressed the proliferation, migration and invasion of pancreatic cancer cells through miR-137-3p/PTN axis." 2 "Circ_0015756 promotes proliferation, invasion and migration by microRNA-7-dependent inhibition of FAK in hepatocellular carcinoma." hsa_circ_0015756 hsa_circ_CFH circ_0015756 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0015756 knockdown was shown to increase the expression of miR-7, reduce the proliferation, invasion, migration and resistance to apoptosis, and down-regulate the expression of FAK in HCC." 3 Hsa_circ_0042666 inhibits proliferation and invasion via regulating miR-223/TGFBR3 axis in laryngeal squamous cell carcinoma. hsa_circ_0042666 hsa_circ_SUPT6H - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR down-regulated hsa_circ_0042666 regulated LSCC cells proliferation and invasion by miR-223/TGFBR3 axis. 1 Preliminary Exploration of hsa_circ_0032131 Levels in Peripheral Blood as a Potential Diagnostic Biomarker of Osteoarthritis. hsa_circ_0032131 hsa_circ_PRKCH - DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" dysregulated Our research indicates that differentially expressed circRNAs may be involved in the development of OA and could be used diagnostically. 3 Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients. - hsa_circ_FOXO3 circFoxo3 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR down-regulated low expression of circ-Foxo3 and Foxo3 were frequent in AML patients. 1 Plasma hsa_circ_0027089 is a diagnostic biomarker for hepatitis B virus-related hepatocellular carcinoma. hsa_circ_0027089 hsa_circ_PTGES3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Twenty-four circRNAs were further investigated via quantitative reverse-transcriptase-polymerase chain reaction assay in a training cohort (n = 48), hsa_circ_0027089 exhibited the highest significance and further distinguished 64 HCC patients from 40 cirrhosis patients and 72 healthy participants in a validation cohort." 2 circFBXW7 Inhibits Malignant Progression by Sponging miR-197-3p and Encoding a 185-aa Protein in Triple-Negative Breast Cancer. - hsa_circ_FBXW7 - DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR down-regulated circFBXW7 sponges miR-197-3p and encodes the FBXW7-185aa protein to suppress TNBC progression through upregulating FBXW7 expression. 1 CircRNA UBAP2 promotes the progression of ovarian cancer by sponging microRNA-144. - hsa_circ_UBAP2 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated CircUBAP2 promotes the progression of ovarian cancer by adsorbing microRNA-144. 1 Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. - hsa_circ_Fndc3b - DOID:5844 myocardial infarction myocardial Infarction RT-qPCR down-regulated circFndc3b interacts with the RNA binding protein Fused in Sarcoma to regulate VEGF expression and signaling. 1 Downregulation of CircRNA CDR1as specifically triggered low-dose Diosbulbin-B induced gastric cancer cell death by regulating miR-7-5p/REGgamma axis. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:10534 stomach cancer gastric cancer RT-qPCR dysregulated knock-down of CircRNA CDR1as specifically promoted the cytotoxic effects of low-dose DB on GC cells instead of hepatocytes by regulating miR-7-5p/REGgamma axis. 2 Upregulated circ_0005576 facilitates cervical cancer progression via the miR-153/KIF20A axis. hsa_circ_0005576 hsa_circ_CDC42 circ_0005576 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circ_0005576/miR-153-3p/KIF20A axis promoting CC progression. 2 Comprehensive expression profiles and bioinformatics analysis reveal special circular RNA expression and potential predictability in the peripheral blood of humans with idiopathic membranous nephropathy. - - hsa_circ_101319 DOID:10976 membranous glomerulonephritis idiopathic membranous nephropathy "RT-qPCR, microarray" up-regulated The levels of circ_101319 were significantly higher (P<0.001) and exhibited promising diagnostic value in patients with IMN (area under ROC =0.89). The co_expression network constructed for circ_101319 indicated that it may be associated with membranous nephropathy_related pathways by mediating miRNAs. 1 Comprehensive circular RNA profiling reveals the regulatory role of the hsa_circ_0137606/miR_1231 pathway in bladder cancer progression. hsa_circ_0137606 hsa_circ_NIPSNAP3A - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "hsa_circ_0137606, could suppress BC proliferation and metastasis by sponging miR_1231." 1 Circular RNA hsa_circ_0053277 promotes the development of colorectal cancer by upregulating matrix metallopeptidase 14 via miR-2467-3p sequestration. hsa_circ_0053277 hsa_circ_NRBP1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated hsa_circ_0053277 facilitated the development of CRC by sponging miR-2467-3p to upregulate MMP14 expression. 1 Circular RNA Expression Profiles in Vaginal Epithelial Tissue of Women With Lubrication Disorders. - - CBT15_circR_3896 DOID:121 vaginal disease lubrication disorder "RT-qPCR, RNA-seq" down-regulated differences in expression of 6 randomly selected circRNAs were confirmed through real-time quantitative polymerase chain reaction. 1 Circular RNA Expression Profiles in Vaginal Epithelial Tissue of Women With Lubrication Disorders. - - CBT15_circR_136 DOID:121 vaginal disease lubrication disorder "RT-qPCR, RNA-seq" down-regulated differences in expression of 6 randomly selected circRNAs were confirmed through real-time quantitative polymerase chain reaction. 1 Circular RNA Expression Profiles in Vaginal Epithelial Tissue of Women With Lubrication Disorders. - - CBT15_circR_3691 DOID:121 vaginal disease lubrication disorder "RT-qPCR, RNA-seq" down-regulated differences in expression of 6 randomly selected circRNAs were confirmed through real-time quantitative polymerase chain reaction. 1 Circular RNA Expression Profiles in Vaginal Epithelial Tissue of Women With Lubrication Disorders. - - CBT15_circR_3245 DOID:121 vaginal disease lubrication disorder "RT-qPCR, RNA-seq" down-regulated differences in expression of 6 randomly selected circRNAs were confirmed through real-time quantitative polymerase chain reaction. 1 Circular RNA Expression Profiles in Vaginal Epithelial Tissue of Women With Lubrication Disorders. - - CBT15_circR_6041 DOID:121 vaginal disease lubrication disorder "RT-qPCR, RNA-seq" up-regulated differences in expression of 6 randomly selected circRNAs were confirmed through real-time quantitative polymerase chain reaction. 1 Circular RNA Expression Profiles in Vaginal Epithelial Tissue of Women With Lubrication Disorders. - - CBT15_circR_6841 DOID:121 vaginal disease lubrication disorder "RT-qPCR, RNA-seq" up-regulated differences in expression of 6 randomly selected circRNAs were confirmed through real-time quantitative polymerase chain reaction. 1 The circular RNA PVT1/miR-203/HOXD3 pathway promotes the progression of human hepatocellular carcinoma. - hsa_circ_PVT1 circPVT1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circPVT1 participates in the progression of HCC through the miR-203/homeobox D3 (HOXD3) pathway. 3 CeRNA Expression Profiling Identifies KIT-Related circRNA-miRNA-mRNA Networks in Gastrointestinal Stromal Tumour. hsa_circ_0069765 hsa_circ_KIT circ_0069765 DOID:9253 gastrointestinal stromal tumor gastrointestinal stromal tumour "RT-qPCR, RNA-seq" up-regulated "In summary, the present research revealed the ceRNA expression profiles in GISTs and identified that three circRNAs (circ_0069765, circ_0079471 and circ_0084097) and three host genes (KIT, ETV1 and PLAT) were upregulated in GISTs using qRT-PCR." 1 CeRNA Expression Profiling Identifies KIT-Related circRNA-miRNA-mRNA Networks in Gastrointestinal Stromal Tumour. hsa_circ_0079471 hsa_circ_PLAT circ_0079471 DOID:9253 gastrointestinal stromal tumor gastrointestinal stromal tumour "RT-qPCR, RNA-seq" up-regulated "In summary, the present research revealed the ceRNA expression profiles in GISTs and identified that three circRNAs (circ_0069765, circ_0079471 and circ_0084097) and three host genes (KIT, ETV1 and PLAT) were upregulated in GISTs using qRT-PCR." 1 CeRNA Expression Profiling Identifies KIT-Related circRNA-miRNA-mRNA Networks in Gastrointestinal Stromal Tumour. hsa_circ_0084097 hsa_circ_ETV1 circ_0084097 DOID:9253 gastrointestinal stromal tumor gastrointestinal stromal tumour "RT-qPCR, RNA-seq" up-regulated "In summary, the present research revealed the ceRNA expression profiles in GISTs and identified that three circRNAs (circ_0069765, circ_0079471 and circ_0084097) and three host genes (KIT, ETV1 and PLAT) were upregulated in GISTs using qRT-PCR." 1 Microarray expression and functional analysis of circular RNAs in the glomeruli of NZB/W F1 mice with lupus nephritis. - - mmu_circRNA_34428 DOID:0080162 lupus nephritis lupus nephritis "RT-qPCR, RNA-seq" up-regulated mmu_circRNA_34428 could serve an important role in LN progression. 1 Circular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a. - hsa_circ_PIP5K1A - DOID:219 colon cancer colon cancer RT-qPCR up-regulated the oncogenic role of the circPIP5K1A-miR-1273a axis in regulation of colon cancer development provides a novel insights into colon cancer pathogenesis. 1 "Crosstalk of mRNA, miRNA, lncRNA, and circRNA and Their Regulatory Pattern in Pulmonary Fibrosis." - - circ949 DOID:3770 pulmonary fibrosis pulmonary fibrosis RNA-seq up-regulated The fibrotic function of lnc949 depended on its host gene FKBP5. circ949 and circ057 formed a regulatory network with lnc865 and lnc556 to simultaneously regulate miR-29b-2-5p targeting STAT3 phosphorylation. 1 "Crosstalk of mRNA, miRNA, lncRNA, and circRNA and Their Regulatory Pattern in Pulmonary Fibrosis." - - circ057 DOID:3770 pulmonary fibrosis pulmonary fibrosis RNA-seq up-regulated The fibrotic function of lnc949 depended on its host gene FKBP5. circ949 and circ057 formed a regulatory network with lnc865 and lnc556 to simultaneously regulate miR-29b-2-5p targeting STAT3 phosphorylation. 1 Upregulated circRNA ARHGAP10 Predicts an Unfavorable Prognosis in NSCLC through Regulation of the miR-150-5p/GLUT-1 Axis. - hsa_circ_ARHGAP10 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" up-regulated Silencing circARHGAP10 also suppressed proliferation and metastasis by targeting the miR-150-5p/GLUT1 axis in NSCLC. 2 "Circular RNA SMARCA5 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by miR-19b-3p/HOXA9 axis." - hsa_circ_SMARCA5 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated circSMARCA5 executed its inhibitory effects on NSCLC cell lines through miR-19b-3p/HOXA9 axis. 2 Circular RNA hsa_circ_0006848 Related to Ribosomal Protein L6 Acts as a Novel Biomarker for Early Gastric Cancer. hsa_circ_0006848 hsa_circ_FOXJ3 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated plasma hsa_circ_0006848 may be a novel noninvasive biomarker in EGC diagnosis. 1 Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop. - hsa_circ_UHRF1 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "circUHRF1 promoted the proliferation, migration, invasion, and epithelial mesenchymal transformation (EMT) in vitro and the tumor growth in vivo." 1 Circular RNA circ-TSPAN4 promotes lung adenocarcinoma metastasis by upregulating ZEB1 via sponging miR-665. - hsa_circ_TSPAN4 circ-TSPAN4 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Circ-TSPAN4 plays a pivotal metastasis-promoting role in LUAD through acting as a sponge for miR-665 and upregulating ZEB1. 1 "Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy." hsa_circ_0101692 - - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, microarray" up-regulated "Three relevant differentially expressed circRNAs were selected (circEGLN3, circNOX4, and circRHOBTB3), their circular nature was experimentally confirmed, and their expression-along with that of their linear counterparts-was measured in 99 malignant and 85 adjacent normal tissue samples using specifically established RT-qPCR assays." 2 "Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy." hsa_circ_0023984 hsa_circ_NOX4 - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, microarray" down-regulated "Three relevant differentially expressed circRNAs were selected (circEGLN3, circNOX4, and circRHOBTB3), their circular nature was experimentally confirmed, and their expression-along with that of their linear counterparts-was measured in 99 malignant and 86 adjacent normal tissue samples using specifically established RT-qPCR assays." 1 "Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy." hsa_circ_0007444 hsa_circ_RHOBTB3 - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, microarray" down-regulated "Three relevant differentially expressed circRNAs were selected (circEGLN3, circNOX4, and circRHOBTB3), their circular nature was experimentally confirmed, and their expression-along with that of their linear counterparts-was measured in 99 malignant and 87 adjacent normal tissue samples using specifically established RT-qPCR assays." 1 Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer. - - circPIEZO1-3 DOID:9256 colorectal cancer colorectal cancer RNA-seq dysregulated "we selected six circRNAs with the most significant differential expression to analyze their circRNA-miRNA-mRNA network. In addition, Kyoto Gene and Genomic Encyclopedia (KEGG) analyses were also performed." 1 Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer. hsa_circ_0067163 hsa_circ_TPRA1 - DOID:9256 colorectal cancer colorectal cancer RNA-seq dysregulated "we selected six circRNAs with the most significant differential expression to analyze their circRNA-miRNA-mRNA network. In addition, Kyoto Gene and Genomic Encyclopedia (KEGG) analyses were also performed." 1 Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer. hsa_circ_0140188 hsa_circ_DMD - DOID:9256 colorectal cancer colorectal cancer RNA-seq dysregulated "we selected six circRNAs with the most significant differential expression to analyze their circRNA-miRNA-mRNA network. In addition, Kyoto Gene and Genomic Encyclopedia (KEGG) analyses were also performed." 1 Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer. hsa_circ_0002632 hsa_circ_STIL - DOID:9256 colorectal cancer colorectal cancer RNA-seq dysregulated "we selected six circRNAs with the most significant differential expression to analyze their circRNA-miRNA-mRNA network. In addition, Kyoto Gene and Genomic Encyclopedia (KEGG) analyses were also performed." 4 Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer. hsa_circ_0001998 hsa_circ_FUT8 - DOID:9256 colorectal cancer colorectal cancer RNA-seq dysregulated "we selected six circRNAs with the most significant differential expression to analyze their circRNA-miRNA-mRNA network. In addition, Kyoto Gene and Genomic Encyclopedia (KEGG) analyses were also performed." 1 Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer. hsa_circ_0023990 hsa_circ_NOX4 - DOID:9256 colorectal cancer colorectal cancer RNA-seq dysregulated "we selected six circRNAs with the most significant differential expression to analyze their circRNA-miRNA-mRNA network. In addition, Kyoto Gene and Genomic Encyclopedia (KEGG) analyses were also performed." 2 CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circRNA Cdr1as serves as a ceRNA to promote the progression of HCC. 4 CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis. - hsa_circ_ERCC2 - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" up-regulated The effects of circERCC2 on NPCs and IVDD rat model were mediated by miR-182-5p/SIRT1 axis. 1 CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK((1/2))/mTOR signaling pathways in oral squamous cell carcinomas. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated high expression of circCDR1as enhanced the viability of OSCC cells under a hypoxic microenvironment by promoting autophagy. 1 circRNA CDR1as Regulated the Proliferation of Human Periodontal Ligament Stem Cells under a Lipopolysaccharide-Induced Inflammatory Condition. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:824 periodontitis periodontitis RT-qPCR down-regulated CDR1as functioned as an miR-7 sponge to activate the ERK signal pathway to mediate the inhibition effect of LPS on cell proliferation. 1 Circular RNA CDR1as sponges miR-7-5p to enhance E2F3 stability and promote the growth of nasopharyngeal carcinoma. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated CircRNA CDR1as promoted the occurrence and development of NPCs by successively up-regulating the expression of miR-7-5p and E2F3. 1 CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma. - hsa_circ_UBAP2 - DOID:1793 pancreatic cancer pancreatic cancer microarray up-regulated circUBAP2-mediated ceRNA network modulates PAAD by regulating the infiltration and function of immune cells. 1 Profiling and bioinformatics analyses reveal differential circular RNA expression in ovarian cancer. hsa_circ_0002711 hsa_circ_NRIP1 - DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, RNA-seq" up-regulated "Using real-time PCR, we verified the significant upregulation of these 5 circRNAs in OC patient serum." 2 Profiling and bioinformatics analyses reveal differential circular RNA expression in ovarian cancer. - - chr5:170610175-170632616+ DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, RNA-seq" up-regulated "Using real-time PCR, we verified the significant upregulation of these 5 circRNAs in OC patient serum." 1 Profiling and bioinformatics analyses reveal differential circular RNA expression in ovarian cancer. hsa_circ_0001756 hsa_circ_HIPK2 - DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, RNA-seq" up-regulated "Using real-time PCR, we verified the significant upregulation of these 5 circRNAs in OC patient serum." 3 Profiling and bioinformatics analyses reveal differential circular RNA expression in ovarian cancer. - - chr4:147227078-147230127- DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, RNA-seq" up-regulated "Using real-time PCR, we verified the significant upregulation of these 5 circRNAs in OC patient serum." 1 Profiling and bioinformatics analyses reveal differential circular RNA expression in ovarian cancer. - - chr16:53175091-53191453+ DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, RNA-seq" up-regulated "Using real-time PCR, we verified the significant upregulation of these 5 circRNAs in OC patient serum." 1 Circular RNA CircEZH2 Suppresses Transmissible Gastroenteritis Coronavirus-induced Opening of Mitochondrial Permeability Transition Pore via Targeting MiR-22 in IPEC-J2. - hsa_circ_EZH2 - DOID:2326 gastroenteritis transmissible gastroenteritis RT-qPCR up-regulated circular RNA circEZH2 was down-regulated during TGEV infection and promoted the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-¦ĘB) via targeting miR-22 in porcine intestinal epithelial cell line (IPEC-J2). 1 Reduction of circular RNA Foxo3 promotes prostate cancer progression and chemoresistance to docetaxel. - hsa_circ_FOXO3 circFoxo3 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "CircFoxo3 inhibited prostate cancer cell survival, migration, invasion and chemoresistance to docetaxel, which was related to circFoxo3s repression of Foxo3 and EMT." 2 Circular RNA hsa_circ_0016070 Is Associated with Pulmonary Arterial Hypertension by Promoting PASMC Proliferation. hsa_circ_0016070 hsa_circ_ATP2B4 - DOID:14557 primary pulmonary hypertension pulmonary arterial hypertension microarray up-regulated hsa_circ_0016070 was associated with vascular remodeling in PAH by promoting the proliferation of pulmonary artery smooth muscle cells (PASMCs) via the miR-942/CCND1. 2 Circ-HIPK3 Strengthens the Effects of Adrenaline in Heart Failure by MiR-17-3p - ADCY6 Axis. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:114 heart disease heart failure RT-qPCR up-regulated the increased circ-HIPK3 can be a helper for adrenaline but was harmful for heart in the long run and might be an ideal therapeutic target of HF. 4 "The circ_0021977/miR-10b-5p/P21 and P53 regulatory axis suppresses proliferation, migration, and invasion in colorectal cancer." hsa_circ_0021977 - circ_0021977 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ_0021977/miR-10b-5p/p21&p53 regulatory axis suppresses proliferation, migration, and invasion by CRC cells." 1 Hsa_circ_0028502 and hsa_circ_0076251 are potential novel biomarkers for hepatocellular carcinoma. hsa_circ_0028502 hsa_circ_SLC24A6 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated hsa_circ_0028502 and hsa_circ_0076251 were potentially valuable biomarkers for HCC diagnosis. 1 Hsa_circ_0028502 and hsa_circ_0076251 are potential novel biomarkers for hepatocellular carcinoma. hsa_circ_0076252 hsa_circ_ZFAND3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated hsa_circ_0028502 and hsa_circ_0076252 were potentially valuable biomarkers for HCC diagnosis. 1 Aberrant dysregulated circular RNAs in the peripheral blood mononuclear cells of patients with rheumatoid arthritis revealed by RNA sequencing: novel diagnostic markers for RA. hsa_circ_0000396 hsa_circ_SLC38A1 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RNA-seq up-regulated hsa_circ_0000396 and hsa_circ_0130438 were downregulated in the RA group versus the healthy group. 2 Aberrant dysregulated circular RNAs in the peripheral blood mononuclear cells of patients with rheumatoid arthritis revealed by RNA sequencing: novel diagnostic markers for RA. hsa_circ_0130438 hsa_circ_KPNA5 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RNA-seq up-regulated hsa_circ_0000396 and hsa_circ_0130438 were downregulated in the RA group versus the healthy group. 2 Circular RNA HIPK3 induces cell proliferation and inhibits apoptosis in non-small cell lung cancer through sponging miR-149. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circHIPK3 regulates the function of NSCLCs through miR-149-mediated FOXM1 expression regulation. 4 Circ_0000218 plays a carcinogenic role in colorectal cancer progression by regulating miR-139-3p/RAB1A axis. hsa_circ_0000218 - circ_0000218 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0000218 upregulated RAB1A and promoted CRC proliferation and metastasis via sponging miR-139-3p. 1 Circular circ_0000885 promotes hepatocellular carcinoma proliferation by epigenetically upregulating Caprin1. hsa_circ_0000885 - circ_0000885 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circular circ_0000885 promotes hepatocellular carcinoma proliferation by epigenetically upregulating Caprin1. 1 Upregulation of circHIPK3 promotes the progression of gastric cancer via Wnt/beta-catenin pathway and indicates a poor prognosis. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircHIPK3 promotes GC cells to proliferate and migrate by regulating the Wnt/beta-catenin pathway. 6 Knockdown of circular RNA CEP128 suppresses proliferation and improves cytotoxic efficacy of temozolomide in glioma cells by regulating miR-145-5p. - hsa_circ_CEP128 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated Knockdown of circular RNA CEP128 suppresses cell proliferation and improves the cytotoxic efficacy of temozolomide in glioma cells by regulating miR-145-5p. 1 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. - hsa_circ_PAX5 - DOID:9952 acute lymphoblastic leukemia pediatric acute lymphoblastic leukemia RNA-seq up-regulated circRNAs specific of B-cells. 1 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. - hsa_circ_AFF3 - DOID:9952 acute lymphoblastic leukemia pediatric acute lymphoblastic leukemia RNA-seq up-regulated circRNAs specific of B-cells. 1 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. - hsa_circ_IL4R - DOID:9952 acute lymphoblastic leukemia pediatric acute lymphoblastic leukemia RNA-seq up-regulated circRNAs specific of B-cells. 1 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. - hsa_circ_SETBP1 - DOID:9952 acute lymphoblastic leukemia pediatric acute lymphoblastic leukemia RNA-seq up-regulated circRNAs specific of B-cells. 1 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. - hsa_circ_IKZF1 - DOID:9952 acute lymphoblastic leukemia acute lymphoblastic leukemia RNA-seq up-regulated circRNAs specific of T-cells. 1 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. - hsa_circ_TNIK - DOID:9952 acute lymphoblastic leukemia acute lymphoblastic leukemia RNA-seq up-regulated circRNAs specific of T-cells. 1 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. - hsa_circ_TXK - DOID:9952 acute lymphoblastic leukemia acute lymphoblastic leukemia RNA-seq up-regulated circRNAs specific of T-cells. 1 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. - hsa_circ_FBXW7 - DOID:9952 acute lymphoblastic leukemia acute lymphoblastic leukemia RNA-seq up-regulated circRNAs specific of T-cells. 1 Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma. hsa_circ_0002130 hsa_circ_C3 - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" up-regulated The results indicated that 10 out of 13 circRNAs showed the same change trends and statistical significance as the circRNA-seq data. 1 Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma. hsa_circ_0000896 hsa_circ_FARSA - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" up-regulated The results indicated that 10 out of 14 circRNAs showed the same change trends and statistical significance as the circRNA-seq data. 1 Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma. hsa_circ_0101692 - - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" up-regulated The results indicated that 10 out of 15 circRNAs showed the same change trends and statistical significance as the circRNA-seq data. 1 Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma. hsa_circ_0005882 hsa_circ_STK39 - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" up-regulated The results indicated that 10 out of 16 circRNAs showed the same change trends and statistical significance as the circRNA-seq data. 1 Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma. hsa_circ_0001250 hsa_circ_GRAMD4 - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" up-regulated The results indicated that 10 out of 17 circRNAs showed the same change trends and statistical significance as the circRNA-seq data. 1 Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma. hsa_circ_0000128 hsa_circ_TNFAIP8L2-SCNM1 circ_TNFAIP8L2-SCNM1 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" up-regulated The results indicated that 10 out of 18 circRNAs showed the same change trends and statistical significance as the circRNA-seq data. 1 Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma. hsa_circ_0103896 - - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" down-regulated The results indicated that 10 out of 19 circRNAs showed the same change trends and statistical significance as the circRNA-seq data. 1 Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma. hsa_circ_0006662 hsa_circ_GLS - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" down-regulated The results indicated that 10 out of 20 circRNAs showed the same change trends and statistical significance as the circRNA-seq data. 1 Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma. hsa_circ_0035432 hsa_circ_CGNL1 - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" down-regulated The results indicated that 10 out of 21 circRNAs showed the same change trends and statistical significance as the circRNA-seq data. 1 Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma. hsa_circ_0094190 - - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" down-regulated The results indicated that 10 out of 22 circRNAs showed the same change trends and statistical significance as the circRNA-seq data. 1 Hsa_circ_0070269 inhibits hepatocellular carcinoma progression through modulating miR-182/NPTX1 axis. hsa_circ_0070269 hsa_circ_PLAC8 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "hsa_circ_0070269 increased NPTX1 expression via sponging miR-182 in HCC cells, which inhibited aggressive tumor behavior." 1 The circular RNA ZNF292 alleviates OGD-induced injury in H9c2 cells via targeting BNIP3. - hsa_circ_ZNF292 - DOID:114 heart disease ischemic heart disease RT-qPCR up-regulated circZNF292 released OGD-induced damage in the H9c2 cells by targeting the BNIP3 through Wnt/beta-catenin and mTOR activation. 1 circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress. - hsa_circ_DLPAG4 - DOID:1287 cardiovascular system disease cardiovascular disease RT-qPCR up-regulated Our results suggest a critical role for circDLGAP4 and HECTD1 in endothelial cell dysfunction induced by I/R. 1 Hsa_circ_0000479 as a Novel Diagnostic Biomarker of Systemic Lupus Erythematosus. hsa_circ_0000479 hsa_circ_EPSTI1 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, RNA-seq" up-regulated hsa_circ_0000479 has potential as a novel biomarker for the diagnosis of SLE. 2 Circ_0026344 restrains metastasis of human colorectal cancer cells via miR-183. hsa_circ_0026344 - circ_0026344 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Silence of circ_0026344 promotes CRC cells migration, invasion and EMT process; miR-183 is a downstream effector of circ_0026344." 2 Circular RNA Pleiotrophin promotes carcinogenesis in glioma via regulation of microRNA-122/SRY-box transcription factor 6 axis. - hsa_circ_PTN - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Circ_PTN acted as a sponge of miR-122 and upregulated miR-122 target SOX6, thus promoting carcinogenesis of glioma cells." 3 Circular RNA expression profiles alter significantly after intracerebral hemorrhage in rats. - - rno_circRNA_011054 DOID:6713 cerebrovascular disease intracerebral hemorrhage "RT-qPCR, microarray" up-regulated The expression level of 2 up-regulated (rno_circRNA_011054 and rno_circRNA_005098) and 1 down-regulated (rno_circRNA_012556) statistically altered after ICH compared with the sham groups and these results were consistent with the microarray data. 1 Circular RNA expression profiles alter significantly after intracerebral hemorrhage in rats. - - rno_circRNA_005098 DOID:6713 cerebrovascular disease intracerebral hemorrhage "RT-qPCR, microarray" up-regulated The expression level of 2 up-regulated (rno_circRNA_011054 and rno_circRNA_005098) and 1 down-regulated (rno_circRNA_012556) statistically altered after ICH compared with the sham groups and these results were consistent with the microarray data. 1 Circular RNA expression profiles alter significantly after intracerebral hemorrhage in rats. - - rno_circRNA_012556 DOID:6713 cerebrovascular disease intracerebral hemorrhage "RT-qPCR, microarray" down-regulated The expression level of 2 up-regulated (rno_circRNA_011054 and rno_circRNA_005098) and 1 down-regulated (rno_circRNA_012556) statistically altered after ICH compared with the sham groups and these results were consistent with the microarray data. 1 Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia. - hsa_circ_RPL15 circ-RPL15 DOID:1040 chronic lymphocytic leukemia chronic lymphocytic leukemia RT-qPCR up-regulated Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia. 1 Exosomal Circular RNA as a Biomarker Platform for the Early Diagnosis of Immune-Mediated Demyelinating Disease. hsa_circ_0087862 hsa_circ_RAD23B - DOID:3213 demyelinating disease demyelinating disease "RT-qPCR, microarray" up-regulated "The expressions of hsa_circ_0087862 and hsa_circ_0012077 in immune-mediated demyelinating disease samples were upregulated 3.55-fold and 1.45-fold, respectively, compared with control samples, with statistically significant differences; the expressions of hsa_circ_0001627 and hsa_circ_0082352 in immune-mediated demyelinating disease samples were downregulated 1.18-fold and 1.05-fold, respectively, compared with control samples." 1 Exosomal Circular RNA as a Biomarker Platform for the Early Diagnosis of Immune-Mediated Demyelinating Disease. hsa_circ_0012077 hsa_circ_PTPRF - DOID:3213 demyelinating disease demyelinating disease "RT-qPCR, microarray" up-regulated "The expressions of hsa_circ_0087862 and hsa_circ_0012077 in immune-mediated demyelinating disease samples were upregulated 3.55-fold and 1.45-fold, respectively, compared with control samples, with statistically significant differences; the expressions of hsa_circ_0001627 and hsa_circ_0082352 in immune-mediated demyelinating disease samples were downregulated 1.18-fold and 1.05-fold, respectively, compared with control samples." 1 Exosomal Circular RNA as a Biomarker Platform for the Early Diagnosis of Immune-Mediated Demyelinating Disease. hsa_circ_0001627 hsa_circ_BACH2 - DOID:3213 demyelinating disease demyelinating disease "RT-qPCR, microarray" down-regulated "The expressions of hsa_circ_0087862 and hsa_circ_0012077 in immune-mediated demyelinating disease samples were upregulated 3.55-fold and 1.45-fold, respectively, compared with control samples, with statistically significant differences; the expressions of hsa_circ_0001627 and hsa_circ_0082352 in immune-mediated demyelinating disease samples were downregulated 1.18-fold and 1.05-fold, respectively, compared with control samples." 1 Exosomal Circular RNA as a Biomarker Platform for the Early Diagnosis of Immune-Mediated Demyelinating Disease. hsa_circ_0082352 hsa_circ_TMEM209 - DOID:3213 demyelinating disease demyelinating disease "RT-qPCR, microarray" down-regulated "The expressions of hsa_circ_0087862 and hsa_circ_0012077 in immune-mediated demyelinating disease samples were upregulated 3.55-fold and 1.45-fold, respectively, compared with control samples, with statistically significant differences; the expressions of hsa_circ_0001627 and hsa_circ_0082352 in immune-mediated demyelinating disease samples were downregulated 1.18-fold and 1.05-fold, respectively, compared with control samples." 1 Selective downregulation of distinct circRNAs in the tissues and plasma of patients with primary hepatic carcinoma. hsa_circ_0003056 hsa_circ_PITPNB - DOID:684 hepatocellular carcinoma hepatic carcinoma "RT-qPCR, RNA-seq" up-regulated The results indicated that hsa_circ_0003056 exhibited reduced expression in PHC tissues. 1 Selective downregulation of distinct circRNAs in the tissues and plasma of patients with primary hepatic carcinoma. hsa_circ_0067127 hsa_circ_ALDH1L1 - DOID:684 hepatocellular carcinoma hepatic carcinoma "RT-qPCR, RNA-seq" up-regulated hsa_circ_0067127 was significantly downregulated in the patients plasma. 1 "Changing expression profiles of lncRNAs, circRNAs and mRNAs in esophageal squamous carcinoma." hsa_circ_0025580 hsa_circ_SLCO1B3 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "circRNAs hsa_circ_0025580, hsa_circ_0024108 and hsa_circ_0025933 were upregulated in ESCC compared with those of the control." 1 "Changing expression profiles of lncRNAs, circRNAs and mRNAs in esophageal squamous carcinoma." hsa_circ_0024108 hsa_circ_MMP1 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "circRNAs hsa_circ_0025580, hsa_circ_0024108 and hsa_circ_0025933 were upregulated in ESCC compared with those of the control." 1 "Changing expression profiles of lncRNAs, circRNAs and mRNAs in esophageal squamous carcinoma." hsa_circ_0025933 hsa_circ_NELL2 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "circRNAs hsa_circ_0025580, hsa_circ_0024108 and hsa_circ_0025933 were upregulated in ESCC compared with those of the control." 2 The integrative regulatory network of circRNA and microRNA in keloid scarring. hsa_circ_0057452 hsa_circ_COL5A2 - DOID:10881 "hand, foot and mouth disease" keloid "RT-qPCR, microarray" up-regulated "hsa_circ_0057452, hsa_circ_0007482, hsa_circ_0020792, hsa_circ_0057342, and hsa_circ_0043688 were significantly upregulated in keloid tissues." 2 The integrative regulatory network of circRNA and microRNA in keloid scarring. hsa_circ_0007482 hsa_circ_COL5A1 - DOID:10881 "hand, foot and mouth disease" keloid "RT-qPCR, microarray" up-regulated "hsa_circ_0057452, hsa_circ_0007482, hsa_circ_0020792, hsa_circ_0057342, and hsa_circ_0043688 were significantly upregulated in keloid tissues." 1 The integrative regulatory network of circRNA and microRNA in keloid scarring. hsa_circ_0020792 hsa_circ_INS-IGF2 - DOID:10881 "hand, foot and mouth disease" keloid "RT-qPCR, microarray" up-regulated "hsa_circ_0057452, hsa_circ_0007482, hsa_circ_0020792, hsa_circ_0057342, and hsa_circ_0043688 were significantly upregulated in keloid tissues." 1 The integrative regulatory network of circRNA and microRNA in keloid scarring. hsa_circ_0057342 hsa_circ_COL3A1 - DOID:10881 "hand, foot and mouth disease" keloid "RT-qPCR, microarray" up-regulated "hsa_circ_0057452, hsa_circ_0007482, hsa_circ_0020792, hsa_circ_0057342, and hsa_circ_0043688 were significantly upregulated in keloid tissues." 1 The integrative regulatory network of circRNA and microRNA in keloid scarring. hsa_circ_0043688 hsa_circ_FKBP10 - DOID:10881 "hand, foot and mouth disease" keloid "RT-qPCR, microarray" up-regulated "hsa_circ_0057452, hsa_circ_0007482, hsa_circ_0020792, hsa_circ_0057342, and hsa_circ_0043688 were significantly upregulated in keloid tissues." 2 Identification of hsa_circ_0001821 as a Novel Diagnostic Biomarker in Gastric Cancer via Comprehensive Circular RNA Profiling. hsa_circ_0001821 hsa_circ_TCONS_00015354 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0001821 was demonstrated to mainly locate in the cytoplasm, implying that it played a potential regulatory role in GC at the posttranscriptional level." 1 Association of circular RNAs and environmental risk factors with coronary heart disease. hsa_circ_0008507 hsa_circ_GBA3 - DOID:3393 coronary artery disease coronary heart disease "RT-qPCR, RNA-seq" up-regulated "Hsa_circ_0008507, hsa_circ_0001946 and hsa_circ_0000284 were closely related to the occurrence and development of CHD." 1 Association of circular RNAs and environmental risk factors with coronary heart disease. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3393 coronary artery disease coronary heart disease "RT-qPCR, RNA-seq" up-regulated "Hsa_circ_0008507, hsa_circ_0001946 and hsa_circ_0000284 were closely related to the occurrence and development of CHD." 1 Association of circular RNAs and environmental risk factors with coronary heart disease. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:3393 coronary artery disease coronary heart disease "RT-qPCR, RNA-seq" up-regulated "Hsa_circ_0008507, hsa_circ_0001946 and hsa_circ_0000284 were closely related to the occurrence and development of CHD." 2 N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. - hsa_circ_NSUN2 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "N6-methyladenosine modification of circNSUN2 modulates cytoplasmic export and stabilizes HMGA2 to promote CRC LM, and suggest that circNSUN2 could represent a critical prognostic marker and/or therapeutic target for the disease." 3 CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer. - hsa_circ_PLEKHM3 - DOID:2394 ovarian cancer ovarian cancer RNA-seq up-regulated circPLEKHM3 functions as a tumor suppressor in ovarian cancer cells by targeting the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis. 2 Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression. - hsa_circ_FOXP1 - DOID:3121 gallbladder cancer gallbladder cancer "RT-qPCR, RNA-seq" up-regulated circFOXP1 serve as a prognostic biomarker and critical regulator in GBC progression and Warburg effect. 1 circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression. - hsa_circ_AF4 - DOID:0081037 mixed phenotype acute leukemia with MLL rearranged mll leukemia RT-qPCR up-regulated the abnormal elevated expression of circAF4 regulates the cell growth via the circAF4/miR-128-3p/MLL-AF4 axis. 1 Circular RNA circ0005276 promotes the proliferation and migration of prostate cancer cells by interacting with FUS to transcriptionally activate XIAP. hsa_circ_0005276 hsa_circ_XIAP circ0005276 DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated circ0005276 interacted with FUS binding protein (FUS) so as to activate the transcription of XIAP. 1 [Effects of circular RNA circ-SOD2 on intestinal epithelial barrier and ulcerative colitis]. - hsa_circ_SOD2 - DOID:8577 ulcerative colitis ulcerative colitis "RT-qPCR, microarray" up-regulated "The dysregulation of circRNAs existed in UC inflamed colorectal mucosa, among which, the upregulated circ-SOD2 weakened the intestinal epithelial barrier and thus might promote the occurrence of ulcerative colitis." 1 Expression Profiles of lncRNAs and circRNAs in Keloid. hsa_circ_0000994 hsa_circ_SLC8A1 - DOID:37 skin disease scar "RT-qPCR, RNA-seq" down-regulated "Expression profiles of mRNAs, lncRNAs, and circRNAs were altered in keloid tissue, which may partly contribute to the etiology of keloids by affecting several signaling pathways relevant to scar wound healing. A better understanding of keloids pathogenesis may identify new therapeutic targets for keloids." 1 Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker. hsa_circ_0044516 - circ_0044516 DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated circ_0044516 played an important role in prostate cancer cell survival and metastasis. 2 Circular RNA expression profile in peripheral whole blood of lung adenocarcinoma by high: Throughput sequencing. - - circRNA5430 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated "Our study revealed that circRNAs were abnormally expressed in PWB of LA, which might offer potential targets for the early diagnosis of the disease and new genetic insights into LA." 1 Circular RNA expression profile in peripheral whole blood of lung adenocarcinoma by high: Throughput sequencing. - - circRNA6783 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated "Our study revealed that circRNAs were abnormally expressed in PWB of LA, which might offer potential targets for the early diagnosis of the disease and new genetic insights into LA." 1 CircRNA cRAPGEF5 inhibits the growth and metastasis of renal cell carcinoma via the miR-27a-3p/TXNIP pathway. - hsa_circ_RAPGEF5 cRAPGEF5 DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated cRAPGEF5 plays a role in suppressing RCC via the miR-27a-3p/TXNIP pathway. 1 A circular RNA from APC inhibits the proliferation of diffuse large B-cell lymphoma by inactivating Wnt/beta-catenin signaling via interacting with TET1 and miR-888. hsa_circ_0127621 hsa_circ_APC - DOID:0050745 diffuse large B-cell lymphoma diffuse large b-cell lymphoma "RT-qPCR, RNA-seq" up-regulated "circ-APC is a novel proliferation inhibitor, and that restoring circ-APC expression may be a promising therapeutic approach for DLBCL patients." 1 Expression profile of circular RNA s in TMJ osteoarthritis synovial tissues and potential functions of hsa_circ_0000448 with specific back-spliced junction. hsa_circ_0000448 hsa_circ_GCN1L1 - DOID:8398 osteoarthritis temporomandibular joint osteoarthritis RT-qPCR up-regulated circRNAs in TMJ synovial tissue participate in the progression of TMJOA and may become a potential therapeutic target. The highly up-regulated has_circ_0000448 probably promotes TNF-alpha secretion of synovium through CeRNA mechanism in TMJOA. 2 The roles of circRFWD2 and circINO80 during NELL-1-induced osteogenesis. - hsa_circ_RFWD2 - DOID:12347 osteogenesis imperfecta osteogenesis RNA-seq up-regulated circRFWD2 and circINO80 could regulate the expression of hsa-miR-6817-5p and influence the recombinant NELL-1-induced osteogenic differentiation of hASCs. 1 The roles of circRFWD2 and circINO80 during NELL-1-induced osteogenesis. - hsa_circ_INO80 - DOID:12347 osteogenesis imperfecta osteogenesis RNA-seq up-regulated circRFWD2 and circINO80 could regulate the expression of hsa-miR-6817-5p and influence the recombinant NELL-1-induced osteogenic differentiation of hASCs. 1 Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI. - hsa_circ_DNMT3B - DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR up-regulated "Downregulation of circDNMT3B contributes to vascular dysfunction in diabetic retinas through regulating miR-20b-5p and BAMBI, providing a potential treatment strategy for diabetic retinopathy." 1 Potential Role of circPVT1 as a proliferative factor and treatment target in esophageal carcinoma. - hsa_circ_PVT1 - DOID:1107 esophageal carcinoma esophageal carcinoma RT-qPCR up-regulated circPVT1 may affect the malignancy of the tumor by affecting miRNA and regulating the levels of Paxs and PPARs. 1 Identification of differentially expressed circRNAs and a novel hsa_circ_0000144 that promote tumor growth in gastric cancer. hsa_circ_0000144 hsa_circ_SLAMF6 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Hsa_circ_0000144 promotes GC cell proliferation, migration, and invasion." 3 Circular RNA circFNDC3B protects renal carcinoma by miR-99a downregulation. - hsa_circ_FNDC3B - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated "Overexpression of circFNDC3B enhanced cell viability, colony formation and migration by miR-99a downregulation via JAK1/STAT3 and MEK/ERK pathways." 1 Upregulation of circular RNA circ_FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR_646/VAMP2 and miR_647/MDM2 signaling pathways. - hsa_circ_FAM53B circ_FAM53B DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "circ_FAM53B could be a competing endogenous RNA (ceRNA) to competitively sponge miR_646 and miR_647 to upregulate VAMP2 and MDM2 expression at the post_transcriptional level, thus mediating the cellular behaviors of OC cells." 1 Microarray profile of circular RNAs identifies hsa_circRNA_102459 and hsa_circRNA_043621 as important regulators in oral squamous cell carcinoma. - - hsa_circRNA_102459 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "circRNA_102459 and circRNA_043621 may function as a tumor_suppressor and promoter, respectively, of OSCC carcinogenesis." 1 Microarray profile of circular RNAs identifies hsa_circRNA_102459 and hsa_circRNA_043621 as important regulators in oral squamous cell carcinoma. - - hsa_circRNA_043621 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "circRNA_102459 and circRNA_043622 may function as a tumor_suppressor and promoter, respectively, of OSCC carcinogenesis." 1 CircRhoC promotes tumorigenicity and progression in ovarian cancer by functioning as a miR-302e sponge to positively regulate VEGFA. - hsa_circ_RhoC - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "the oncogenic effect of RhoC in ovarian cancer is at least in part due to circRhoC, which functions not only as a miR-302e sponge to positively regulate VEGFA protein expression, but may also directly bind and modulate VEGFA expression." 1 Identification of hsa_circ_0005654 as a new early biomarker of gastric cancer. hsa_circ_0005654 hsa_circ_PRDM5 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated hsa_circ_0005654 may serve as a new and promising diagnostic biomarker for screening early gastric cancer. 2 "Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma." - hsa_circ_LARP4 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ-LARP4 high expression correlates with decreased Enneking stage and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging miR-424 in osteosarcoma." 1 Circular RNA circ_0074026 indicates unfavorable prognosis for patients with glioma and facilitates oncogenesis of tumor cells by targeting miR-1304 to modulate ERBB4 expression. hsa_circ_0074026 - circ_0074026 DOID:0060108 brain glioma glioma RT-qPCR up-regulated circ_0074026 modulated ERBB4 to promote tumor progression by regulating miR-1304. 1 Circular RNA circC3P1 restrains kidney cancer cell activity by regulating miR-21/PTEN axis and inactivating PI3K/AKT and NF- kB pathways. - hsa_circ_C3P1 - DOID:263 kidney cancer kidney cancer RT-qPCR down-regulated "circC3P1 restrained KC cell growth, migration, and invasion by regulating miR-21/PTEN axis and inactivating PI3K/AKT and NF-kappaB signaling pathways." 1 Circular RNA circ_0067934 functions as an oncogene in glioma by targeting CSF1. hsa_circ_0067934 - circ_0067934 DOID:0060108 brain glioma glioma RT-qPCR up-regulated The circ_0067934 could suppress cell migration and invasion of glioma by upregulating CSF1. 2 Characterization of hsa_circ_0000594 as a new biomarker and therapeutic target for hepatoblastoma. hsa_circ_0000594 hsa_circ_TTBK2 - DOID:687 hepatoblastoma hepatoblastoma RT-qPCR up-regulated hsa_circ_0000594 was identified to have a critical role in HB development through the hsa_circ_0000594/mir-217/SIRT1 regulatory axis. 1 Circular RNAs expression profiles in plasma exosomes from early-stage lung adenocarcinoma and the potential biomarkers. hsa_circ_0001492 - circ_0001492 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated our study firstly revealed the altered exosomal circRNA expression from plasma samples in patients with LUAD and supports the need for exploring their potential as biomarkers and the pathological effects of lung cancer. 1 Circular RNAs expression profiles in plasma exosomes from early-stage lung adenocarcinoma and the potential biomarkers. hsa_circ_0001346 - circ_0001346 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated our study firstly revealed the altered exosomal circRNA expression from plasma samples in patients with LUAD and supports the need for exploring their potential as biomarkers and the pathological effects of lung cancer. 1 Circular RNAs expression profiles in plasma exosomes from early-stage lung adenocarcinoma and the potential biomarkers. hsa_circ_0000690 - circ_0000690 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated our study firstly revealed the altered exosomal circRNA expression from plasma samples in patients with LUAD and supports the need for exploring their potential as biomarkers and the pathological effects of lung cancer. 1 Circular RNAs expression profiles in plasma exosomes from early-stage lung adenocarcinoma and the potential biomarkers. hsa_circ_0001439 - circ_0001439 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated our study firstly revealed the altered exosomal circRNA expression from plasma samples in patients with LUAD and supports the need for exploring their potential as biomarkers and the pathological effects of lung cancer. 1 Circ_0076305 regulates cisplatin resistance of non-small cell lung cancer via positively modulating STAT3 by sponging miR-296-5p. hsa_circ_0076305 - circ_0076305 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ_0076305 regulated STAT3 expression and DDP resistance of NSCLC cells via sponging miR-296-5p. 1 circIFT80 Functions as a ceRNA of miR-1236-3p to Promote Colorectal Cancer Progression. - hsa_circ_IFT80 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated circIFT80 is a central component linking circRNAs to the progression of CRC via a miR-1236-3p/HOXB7 axis. 3 Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation. - hsa_circ_PICALM - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated CircPICALM can inhibit BC metastasis and bind to miR-1265 to block its pro-invasion activity. 1 Circular RNA USP1 regulates the permeability of blood-tumour barrier via miR-194-5p/FLI1 axis. - hsa_circ_USP1 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "the crucial regulation of circ-USP1 on BTB permeability via miR-194-5p/FLI1 axis-mediated regulation of tight junction proteins, which might facilitate the development of therapeutics against human gliomas." 1 CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of beta-catenin/LEF1 complex via effects on chromatin remodeling. - hsa_circ_MYO10 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to promote chromatin remodeling and thus enhances the transcriptional activity of beta-catenin/LEF1 complex. 1 Identification of differentially expressed circular RNAs in HeLa cells infected with Chlamydia trachomatis. - - hsa_circRNA_001226 DOID:11263 chlamydia chlamydia trachomatis infection "RT-qPCR, RNA-seq" up-regulated "We selected three differentially-expressed circRNAs (hsa_circRNA_001226, hsa_circRNA_007046, and hsa_circRNA_400027), fifteen miRNAs, and thirty-four genes to construct a circRNA/targeted miRNA/gene network." 1 Identification of differentially expressed circular RNAs in HeLa cells infected with Chlamydia trachomatis. - - hsa_circRNA_007046 DOID:11263 chlamydia chlamydia trachomatis infection "RT-qPCR, RNA-seq" up-regulated "We selected three differentially-expressed circRNAs (hsa_circRNA_001226, hsa_circRNA_007046, and hsa_circRNA_400027), fifteen miRNAs, and thirty-four genes to construct a circRNA/targeted miRNA/gene network." 1 Identification of differentially expressed circular RNAs in HeLa cells infected with Chlamydia trachomatis. - - hsa_circRNA_400027 DOID:11263 chlamydia chlamydia trachomatis infection "RT-qPCR, RNA-seq" up-regulated "We selected three differentially-expressed circRNAs (hsa_circRNA_001226, hsa_circRNA_007046, and hsa_circRNA_400027), fifteen miRNAs, and thirty-four genes to construct a circRNA/targeted miRNA/gene network." 1 CircWHSC1 promotes ovarian cancer progression by regulating MUC1 and hTERT through sponging miR-145 and miR-1182. hsa_circ_0001387 hsa_circ_WHSC1 CircWHSC1 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "the highly expressed circWHSC1 in ovarian cancer promotes tumorigenesis by sponging miR-145 and miR-1182, and its exosome forms induce tumor metastasis through acting on peritoneal mesothelium." 1 "Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma." - hsa_circ_E7 - DOID:5525 anal squamous cell carcinoma anal squamous cell carcinoma RT-qPCR up-regulated "circE7 levels correlate with improved survival in ASCC, larger, prospective studies are necessary to confirm the potential role of circE7 as a biomarker." 1 Circ_ANKIB1 stabilizes the regulation of miR-19b on SOCS3/STAT3 pathway to promote osteosarcoma cell growth and invasion. - hsa_circ_ANKIB1 circ_ANKIB1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circ_ANKIB1 could affect the STAT3 pathway and osteosarcoma cell growth and invasion by enhancing the regulation of miR-19b on the downstream target gene SOCS3. 3 Hsa_circ_0001546 acts as a miRNA-421 sponge to inhibit the chemoresistance of gastric cancer cells via ATM/Chk2/p53-dependent pathway. hsa_circ_0001546 hsa_circ_FAM114A2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circ_0001546 sponges miR-421 to upregulate the expression level of ATM and inhibit the proliferation and chemoresistance through the activation of the ATM/Chk2/p53-dependent pathway. 2 "A novel circular RNA, hsa-circ-0000211, promotes lung adenocarcinoma migration and invasion through sponging of hsa-miR-622 and modulating HIF1-alpha expression." hsa_circ_0000211 hsa_circ_SFMBT2 - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated hsa-circ-0000211 promoted LAC cell migration and invasion by modulating the miR-622/HIF1-alpha networ. 1 Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer. - hsa_circ_CCDC66 circ-CCDC66 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated three-circRNA panel improved the ability to diagnose CEA-negative and CA19-9-negative CRC. 4 Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer. - hsa_circ_ABCC1 circ-ABCC1 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated three-circRNA panel improved the ability to diagnose CEA-negative and CA19-10-negative CRC. 2 Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer. - hsa_circ_STIL circ-STIL DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated three-circRNA panel improved the ability to diagnose CEA-negative and CA19-11-negative CRC. 4 Silencing circular RNA hsa_circ_0004491 promotes metastasis of oral squamous cell carcinoma. hsa_circ_0004491 hsa_circ_ORC4 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated The expression level of hsa_circ_0004491 affects the migration and invasion of OSCC cells. 2 Next-generation sequencing reveals hsa_circ_0058092 being a potential oncogene candidate involved in gastric cancer. hsa_circ_0058092 hsa_circ_FN1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated hsa_circ_0058092 was associated with survival of gastric cancer patients. 2 Circ-EZH2 knockdown reverses DDAH1 and CBX3-mediated cell growth and invasion in glioma through miR-1265 sponge activity. - hsa_circ_EZH2 circ-EZH2 DOID:0060108 brain glioma glioma RT-qPCR up-regulated circ-EZH2 served as a miRNA sponge for miR-1265 to release its suppression on DDAH1 and CBX3. 1 Circ-AKT3 inhibits clear cell renal cell carcinoma metastasis via altering miR-296-3p/E-cadherin signals. - hsa_circ_AKT3 circ-AKT3 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, RNA-seq" up-regulated Circ-AKT3 suppresses ccRCC metastasis by enforcing E-cadherin expression through competitively binding miR-296-3p. 1 Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer. hsa_circ_0103398 hsa_circ_THBS1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated High expression of hsa_circ_0103398 and hsa_circ_0127859 was closely associated with unfavorable survival time. 2 Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer. hsa_circ_0127859 hsa_circ_CHSY3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated High expression of hsa_circ_0103398 and hsa_circ_0127860 was closely associated with unfavorable survival time. 1 Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips. hsa_circ_0020014 - hsa_circRNA_0020014 DOID:8398 osteoarthritis kashin-beck disease and osteoarthritis "RT-qPCR, RNA-seq" up-regulated hsa_circRNA_0020014 is a potential biomarker for differential diagnosis between OA and KBD. 2 Circ_0080425 inhibits cell proliferation and fibrosis in diabetic nephropathy via sponging miR-24-3p and targeting fibroblast growth factor 11. - - circ_0080425 DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "circ_0080425 competitive binding to miR-24-3p could release FGF11 from miR-24-3p suppression, which subsequently promoted DN progression." 1 "Silence of cZNF292 suppresses the growth, migration, and invasion of human esophageal cancer Eca-109 cells via upregulating miR-206." - hsa_circ_ZNF292 cZNF292 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "silencing of cZNF292 abated growth, migration, and invasion of Eca-109 cells by upregulating miR-206, which subsequently modulated AMPK and PI3K/AKT signaling pathways." 1 Circular RNA circ-Foxo3 inhibits esophageal squamous cell cancer progression via the miR-23a/PTEN axis. - hsa_circ_FOXO3 circ-Foxo3 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated Circular RNA circ-Foxo3 inhibits esophageal squamous cell cancer progression via the miR-23a/PTEN axis. 1 "Circular RNA circ_0074027 indicates a poor prognosis for NSCLC patients and modulates cell proliferation, apoptosis, and invasion via miR-185-3p mediated BRD4/MADD activation." - - circ_0074027 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated upregulated circ_0074027 in NSCLC accelerates cell progression via miR-185-3p/BRD4/MADD pathway as a competing endogenous RNA. 2 Upregulated circZMIZ1 promotes the proliferation of prostate cancer cells and is a valuable marker in plasma. - hsa_circ_ZMIZ1 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "circZMIZ1 could increase the expression of androgen receptor (AR) and androgen receptor splice variant 7 (AR-V7), which may be partly contributed to the occurrence and development of prostate cancer." 1 Serum circSETDB1 is a promising biomarker for predicting response to platinum-taxane-combined chemotherapy and relapse in high-grade serous ovarian cancer. - hsa_circ_SETDB1 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated serum circSETDB1 may serve as a novel non-invasive biomarker for detecting SOC progression and predicting response to chemotherapy and relapse in high-grade serous ovarian cancer. 3 hsa_circ_0092306 Targeting miR-197-3p Promotes Gastric Cancer Development by Regulating PRKCB in MKN-45 Cells. hsa_circ_0092306 hsa_circ_CCS - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated hsa_circ_0092306 promoted the development of GC by regulating the pathway of miR-197-3p/PRKCB in MKN-45 cells. 1 Circulating Circular RNAs as Biomarkers for the Diagnosis and Prediction of Outcomes in Acute Ischemic Stroke. - hsa_circ_PDS5B - DOID:6713 cerebrovascular disease stroke microarray up-regulated The elevated levels of circPDS5B and circCDC14A after stroke might be because of increased levels in lymphocytes and granulocytes. 1 Circulating Circular RNAs as Biomarkers for the Diagnosis and Prediction of Outcomes in Acute Ischemic Stroke. - hsa_circ_CDC14A - DOID:6713 cerebrovascular disease stroke microarray up-regulated The elevated levels of circPDS5B and circCDC14A after stroke might be because of increased levels in lymphocytes and granulocytes. 2 The circular RNA-NRIP1 plays oncogenic roles by targeting microRNA-505 in the renal carcinoma cell lines. - hsa_circ_NRIP1 - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated the circNRIP1 played oncogenic roles in the ACHN and the CAKI-1 cell lines by targeting miR-505 via stimulating AMPK and PI3K/AKT/mTOR cascades. 1 Silencing circular RNA circANKRD36 remits lipopolysaccharide-induced inflammatory damage by regulating microRNA-15/MyD88. - hsa_circ_ANKRD36 - DOID:8717 decubitus ulcer bedsore RT-qPCR up-regulated MyD88 was authenticated as a target of miR-15. circANKRD36 remitted cell inflammatory damage upregulating miR-15/MyD88 via the NF-kappaB pathway in HaCaT cells. 1 Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice. - - mmu_circRNA_002573 DOID:8466 retinal degeneration retinal neovascularization "RT-qPCR, RNA-seq" up-regulated "In conclusion, our study demonstrated that the interactions of circRNAs and miRNAs may indirectly regulate gene expression and altered circRNA may play a role in retinal neovascularization." 1 Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice. - - mmu_circRNA_011180 DOID:8466 retinal degeneration retinal neovascularization "RT-qPCR, RNA-seq" up-regulated "In conclusion, our study demonstrated that the interactions of circRNAs and miRNAs may indirectly regulate gene expression and altered circRNA may play a role in retinal neovascularization." 1 Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice. - - mmu_circRNA_016108 DOID:8466 retinal degeneration retinal neovascularization "RT-qPCR, RNA-seq" up-regulated "In conclusion, our study demonstrated that the interactions of circRNAs and miRNAs may indirectly regulate gene expression and altered circRNA may play a role in retinal neovascularization." 1 Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice. - - mmu_circRNA_22546 DOID:8466 retinal degeneration retinal neovascularization "RT-qPCR, RNA-seq" up-regulated "In conclusion, our study demonstrated that the interactions of circRNAs and miRNAs may indirectly regulate gene expression and altered circRNA may play a role in retinal neovascularization." 1 circ_0005273 promotes thyroid carcinoma progression by SOX2 expression. hsa_circ_0005273 - circ_0005273 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "circ_0005273 functioned as a tumor promoter of PTC via circ_0005273/miR-1183/SOX2 axis, suggesting a novel biomarker and therapeutic target for PTC." 1 Knockdown of EBV-encoded circRNA circRPMS1 suppresses nasopharyngeal carcinoma cell proliferation and metastasis through sponging multiple miRNAs. - hsa_circ_RPMS1 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated circRPMS1 as a potential therapeutic target for EBV-associated NPC. 1 Silencing Of hsa_circ_0008450 Represses Hepatocellular Carcinoma Progression Through Regulation Of microRNA-214-3p/EZH2 Axis. hsa_circ_0008450 hsa_circ_CMTM3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Knockdown of hsa_circ_0008450 inhibits HCC progression by regulating miR-214-3p/EZH2 axis. 3 Circular RNA circRNA_0000285 promotes cervical cancer development by regulating FUS. hsa_circ_0000285 - circRNA_0000285 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated CircRNA_0000285 could enhance the proliferation and metastasis of CC by up-regulating FUS. 4 Circ_016719 plays a critical role in neuron cell apoptosis induced by I/R via targeting miR-29c/Map2k6. - - circ_016719 DOID:6713 cerebrovascular disease stroke RT-qPCR up-regulated "circ_016719 directly targets miR-29c, and thereby regulates the expression and functions of Map2k6, which significantly contributes to the pro-apoptotic role of circ_016719." 1 Circular RNA circ-FOXP1 induced by SOX9 promotes hepatocellular carcinoma progression via sponging miR-875-3p and miR-421. - hsa_circ_FOXO1 circ-FOXP1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ-FOXP1 is a novel driver for the tumorigenesis and aggressive progression of HCC. 1 A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer. hsa_circ_0082182 hsa_circ_FAM71F2 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0082182, hsa_circ_0000370 and hsa_circ_0035445. ROC curves showed that these circRNAs might have diagnostic value for colorectal cancer." 2 A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer. hsa_circ_0000370 hsa_circ_FLI1 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0082182, hsa_circ_0000370 and hsa_circ_0035445. ROC curves showed that these circRNAs might have diagnostic value for colorectal cancer." 2 A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer. hsa_circ_0035445 hsa_circ_ALDH1A2 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0082182, hsa_circ_0000370 and hsa_circ_0035445. ROC curves showed that these circRNAs might have diagnostic value for colorectal cancer." 1 Comprehensive circular RNA profiling identifies CircFAM120A as a new biomarker of hypoxic lung adenocarcinoma. - hsa_circ_FAM120A - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated circFAM120A may have the potential to be a new biomarker of lung adenocarcinoma hypoxia. 1 Circ-PRMT5 promotes gastric cancer progression by sponging miR-145 and miR-1304 to upregulate MYC. - hsa_circ_PRMT5 circ-PRMT5 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated High circ-PRMT5 expression may provide a poor prognostic indicator of survival in GC patients and targeting circ-PRMT5/miR-145/miR-1304/MYC axis may be a novel therapeutic strategy for GC. 1 circEPSTI1 Acts as a ceRNA to Regulate the Progression of Osteosarcoma. - hsa_circ_EPSTI1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated the circEPSTI1-miR-892b-MCL1 axis affected osteosarcoma progression through the miRNA sponging mechanism. circEPSTI1 may serve as a target and biomarker for osteosarcoma treatment. 1 CircAGFG1 promotes cervical cancer progression via miR-370-3p/RAF1 signaling. - hsa_circ_AGFG1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circAGFG1 promoted proliferation and migration of CC cells via enhancing the activity of RAF/MEK/ERK pathway by sponging miR-370-3p and further regulating RAF1. 1 Hsa_circ_0001361 promotes bladder cancer invasion and metastasis through miR-491-5p/MMP9 axis. hsa_circ_0001361 - circ0001361 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated "circ0001361 plays oncogenic role in BC invasion and metastasis through targeting the miR-491-5p/MMP9 axis, and it might be a potential novel target for BC therapy." 2 Hsa_circ_0075341 is up-regulated and exerts oncogenic properties by sponging miR-149-5p in cervical cancer. hsa_circ_0075341 hsa_circ_MAPK9 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "hsa_circ_0075341 promoted cervical cancer cell proliferation and invasion through regulating the miR-149-5p/AURKA axis, which provided a novel therapeutic target for cervical cancer treatment." 1 Therapeutic targeting of circ-CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression. - hsa_circ_CUX1 circ-CUX1 DOID:769 neuroblastoma neuroblastoma "RT-qPCR, RNA-seq" up-regulated circ-CUX1/EWSR1/MAZ axis as a therapeutic target for aerobic glycolysis and NB progression. 3 Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer. hsa_circ_0000338 - circ_0000338 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0000338 may have dual regulatory roles in chemo-resistant CRC. 2 "Circ-MTO1 correlates with favorable prognosis and inhibits cell proliferation, invasion as well as miR-17-5p expression in prostate cancer." - hsa_circ_MTO1 circ-MTO1 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Circ-MTO1 correlates with decreased pathological T/N stage and favorable survival profiles, and it also inhibits cell proliferation, invasion as well as miR-17-5p expression in prostate cancer." 1 Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma. - hsa_circ_ASH2L circ-ASH2L DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated "circ-ASH2L play an important role in tumor invasion, and high circ-ASH2L may be a useful marker of PDAC diagnosis or progression." 1 Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation. - hsa_circ_HuR circ-HuR DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated Circ-HuR serves as a tumor suppressor to inhibit CNBP-facilitated HuR expression and gastric cancer progression. 1 TGF-beta- and lipopolysaccharide-induced upregulation of circular RNA PWWP2A promotes hepatic fibrosis via sponging miR-203 and miR-223. - hsa_circ_PWWP2A circ-PWWP2A DOID:409 liver disease hepatic fibrosis RT-qPCR up-regulated "circ-PWWP2A is the common downstream reactor of TGF-beta and LPS in HSC activation, and that circ-PWWP2A plays a critical role in hepatic fibrogenesis via sponging miR-203 and miR-223." 1 Circular RNA circGRAMD1B inhibits gastric cancer progression by sponging miR-130a-3p and regulating PTEN and p21 expression. - hsa_circ_GRAMD1B - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circGRAMD1B plays an important role in GC progression by regulating miR-130a-3p-PTEN/p21, which may provide a potential biomarker and therapeutic target for GC." 1 CircZNF609/miR-134-5p/BTG-2 axis regulates proliferation and migration of glioma cell. - hsa_circ_ZNF609 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated CircZNF609 served as a competing RNA to bind miR-134-5p that promoted BTG-2 expression leading to reduced proliferation and migration of glioma cell. 1 Reduced expression of circRNA hsa_circ_0067582 in human gastric cancer and its potential diagnostic values. hsa_circ_0067582 hsa_circ_RASA2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated hsa_circ_000067582 may be a potential biomarker for GC diagnosis and prognosis evaluation. 3 "[Effect of circular RNA hsa_circ_0002203 on the proliferation, migration, invasion, and apoptosis of oral squamous cell carcinoma cells]." hsa_circ_0002203 hsa_circ_CAMTA1 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "The low expression of circular RNA hsa_circ_0002203 in oral squamous cell carcinoma can enhance the proliferation, migration, and invasion of cancer cells and inhibit tumor cell apoptosis." 1 circLMTK2 acts as a sponge of miR-150-5p and promotes proliferation and metastasis in gastric cancer. - hsa_circ_LMTK2 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated circLMTK2 functions as a tumour promoter in GC through the miR-150-5p/c-Myc axis and could thus be a prognostic predictor and therapeutic target for GC. 2 circGSK3beta promotes metastasis in esophageal squamous cell carcinoma by augmenting beta-catenin signaling. - hsa_circ_GSK3beta - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated CircGSK3beta exerts critical roles in promoting ESCC metastasis and may serve as a novel therapeutic target for ESCC patients. 1 Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study. hsa_circ_0000519 hsa_circ_RPPH1 - DOID:1612 breast cancer breast cancer RNA-seq up-regulated The circRNA hsa_circ_0000519 is likely critical in the pathogenesis of breast cancer and may serve as a future therapeutic biomarker. 9 "Circ-SLC7A5, a potential prognostic circulating biomarker for detection of ESCC." - hsa_circ_SLC7A5 circ-SLC7A5 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RNA-seq up-regulated "circ-SLC7A5 are associated with high TNM stage, tending to have shorter overall survival than those with high levels." 1 Circular circPSMC3 inhibits hepatocellular carcinoma migration and invasion by upregulating RBM5. - hsa_circ_PSMC3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circular circPSMC3 inhibits hepatocellular carcinoma migration and invasion by upregulating RBM5. 1 Circular RNA circ_0102049 promotes cell progression as ceRNA to target MDM2 via sponging miR-1304-5p in osteosarcoma. - - circ_0102049 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ_0102049 remarkably accelerated cell proliferation, migration and invasion but attenuated cell apoptosis in OS cells." 2 Circular RNA cESRP1 sensitises small cell lung cancer cells to chemotherapy by sponging miR-93-5p to inhibit TGF-beta signalling. - hsa_circ_ESRP1 cESRP1 DOID:5409 lung small cell carcinoma small cell lung cancer RT-qPCR up-regulated The cESRP1 plays crucial a role in SCLC chemosensitivity by sponging miR-93-5p to inhibit the TGF-beta pathway. 1 circFBXL5 promotes breast cancer progression by sponging miR-660. hsa_circ_0125597 hsa_circ_FBXL5 - DOID:1612 breast cancer breast cancer microarray up-regulated "circFBXL5 acted as a sponge for miR-660 and compete binding to miR-660 with SRSF6, leading to increased expression of SRSF6." 2 Circular RNA circFOXO3 promotes prostate cancer progression through sponging miR-29a-3p. - hsa_circ_FOXO3 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated circFOXO3 acts as a miR-29a-3p sponge to exhibit oncogenic activity that affects the cell cycle and cell apoptosis in PCa through transcriptional up-regulation of SLC25A15. 2 circAtp9b knockdown alleviates LPS-caused inflammation provided that microRNA-27a is upregulated. - hsa_circ_Atp9b - DOID:552 pneumonia lps-caused inflammation RT-qPCR up-regulated LPS triggered adverse inflammation response by elevating the biogenesis of circAtp9b which caused a repressive role in miR-27a expression. 1 Circular RNA hsa_circ_0030018 acts as a sponge of miR-599 to aggravate esophageal carcinoma progression by regulating ENAH expression. hsa_circ_0030018 hsa_circ_POSTN - DOID:1107 esophageal carcinoma esophageal carcinoma RT-qPCR up-regulated hsa_circ_0030018 acted as a sponge of miR-599 to aggravate EC progression by regulating ENAH expression. 1 Circ_0000003 promotes the proliferation and metastasis of non-small cell lung cancer cells via miR-338-3p/insulin receptor substrate 2. hsa_circ_0000003 - circ_0000003 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0000003 promotes the proliferation and metastasis of NSCLC cells via modulating miR-338-3p/IRS2 axis. 1 Identification of Serum Exosomal hsa-circ-0004771 as a Novel Diagnostic Biomarker of Colorectal Cancer. hsa_circ_0004771 hsa_circ_NRIP1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circulating exosomal hsa-circ-0004771 was significantly up-regulated in CRC patients and served as a novel potential diagnostic biomarker of CRC. 2 A novel circFMN2 promotes tumor proliferation in CRC by regulating the miR-1182/hTERT signaling pathways. hsa_circ_0005100 hsa_circ_FMN2 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated circFMN2 is a central component linking circRNAs to progression of CRC via an miR-1182/hTERT axis. 4 Ectopic expression of CYP24A1 circular RNA hsa_circ_0060927 in uterine leiomyomas. hsa_circ_0060927 hsa_circ_CYP24A1 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma RT-qPCR up-regulated hsa_circ_0060927 was ectopically expressed in 33.33% of ULM tissue. 1 CircZFR serves as a prognostic marker to promote bladder cancer progression by regulating miR-377/ZEB2 signaling. - hsa_circ_ZFR - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated circZFR could be a prognostic biomarker in bladder cancer and exerted oncogenic roles through regulating miR-377/ZEB2 axis in bladder cancer. 3 Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs. hsa_circ_0001178 hsa_circ_USP25 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "our data uncover the crucial role of hsa_circ_0001178 in CRC metastasis, and targeted therapy based on this positive feedback ceRNA axis may be a promising treatment for metastatic CRC patients." 3 Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients. hsa_circ_0005941 hsa_circ_FTO - DOID:13207 proliferative diabetic retinopathy proliferative diabetic retinopathy "RT-qPCR, RNA-seq" up-regulated The changed profiling of circRNAs in the vitreous humour was reliable and may become a promising biomarker of DR and the circRNA-miRNA-mRNA network. It may also play an important role in the progression of DR. 1 Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients. hsa_circ_0001897 hsa_circ_POMT1 - DOID:13207 proliferative diabetic retinopathy proliferative diabetic retinopathy "RT-qPCR, RNA-seq" up-regulated The changed profiling of circRNAs in the vitreous humour was reliable and may become a promising biomarker of DR and the circRNA-miRNA-mRNA network. It may also play an important role in the progression of DR. 1 Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients. hsa_circ_0000061 hsa_circ_SCMH1 - DOID:13207 proliferative diabetic retinopathy proliferative diabetic retinopathy "RT-qPCR, RNA-seq" up-regulated The changed profiling of circRNAs in the vitreous humour was reliable and may become a promising biomarker of DR and the circRNA-miRNA-mRNA network. It may also play an important role in the progression of DR. 1 Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients. hsa_circ_0002570 hsa_circ_FAM73A - DOID:13207 proliferative diabetic retinopathy proliferative diabetic retinopathy "RT-qPCR, RNA-seq" up-regulated The changed profiling of circRNAs in the vitreous humour was reliable and may become a promising biomarker of DR and the circRNA-miRNA-mRNA network. It may also play an important role in the progression of DR. 1 Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients. hsa_circ_0000371 hsa_circ_ARHGAP32 - DOID:13207 proliferative diabetic retinopathy proliferative diabetic retinopathy "RT-qPCR, RNA-seq" up-regulated The changed profiling of circRNAs in the vitreous humour was reliable and may become a promising biomarker of DR and the circRNA-miRNA-mRNA network. It may also play an important role in the progression of DR. 1 Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients. hsa_circ_0014614 hsa_circ_DAP3 - DOID:13207 proliferative diabetic retinopathy proliferative diabetic retinopathy "RT-qPCR, RNA-seq" up-regulated The changed profiling of circRNAs in the vitreous humour was reliable and may become a promising biomarker of DR and the circRNA-miRNA-mRNA network. It may also play an important role in the progression of DR. 1 Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients. hsa_circ_0006667 hsa_circ_KLHL24 - DOID:13207 proliferative diabetic retinopathy proliferative diabetic retinopathy "RT-qPCR, RNA-seq" up-regulated The changed profiling of circRNAs in the vitreous humour was reliable and may become a promising biomarker of DR and the circRNA-miRNA-mRNA network. It may also play an important role in the progression of DR. 1 Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients. hsa_circ_0097977 hsa_circ_ATF7IP - DOID:13207 proliferative diabetic retinopathy proliferative diabetic retinopathy "RT-qPCR, RNA-seq" up-regulated The changed profiling of circRNAs in the vitreous humour was reliable and may become a promising biomarker of DR and the circRNA-miRNA-mRNA network. It may also play an important role in the progression of DR. 1 Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients. hsa_circ_0001850 hsa_circ_UBAP2 - DOID:13207 proliferative diabetic retinopathy proliferative diabetic retinopathy "RT-qPCR, RNA-seq" up-regulated The changed profiling of circRNAs in the vitreous humour was reliable and may become a promising biomarker of DR and the circRNA-miRNA-mRNA network. It may also play an important role in the progression of DR. 1 Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients. hsa_circ_0008521 hsa_circ_PSEN1 - DOID:13207 proliferative diabetic retinopathy proliferative diabetic retinopathy "RT-qPCR, RNA-seq" up-regulated The changed profiling of circRNAs in the vitreous humour was reliable and may become a promising biomarker of DR and the circRNA-miRNA-mRNA network. It may also play an important role in the progression of DR. 1 "circMTDH4/miR-630/AEG-1 axis participates in the regulation of proliferation, migration, invasion, chemoresistance, and radioresistance of NSCLC." - hsa_circ_MTDH4 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circMTDH.4 regulated AEG-1 expression via sponging miR-630. 1 Increased circulating circular RNA_103516 is a novel biomarker for inflammatory bowel disease in adult patients. - - circRNA_103516 DOID:0050589 inflammatory bowel disease inflammatory bowel disease RT-qPCR up-regulated Dysregulation of circRNA_103516 may participate in the molecular mechanism of IBD through hsa-miR-19b-1-5p sponging. 1 Up-Regulation of hsa_circ_0000517 Predicts Adverse Prognosis of Hepatocellular Carcinoma. hsa_circ_0000517 hsa_circ_RPPH1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "hsa_circ_0000517, a promising molecular in underlying mechanism of HCC, is a potent valuable biomarker for prognosis prediction." 6 circPUM1 Promotes Tumorigenesis and Progression of Ovarian Cancer by Sponging miR-615-5p and miR-6753-5p. - hsa_circ_PUM1 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "circPUM1 not only promotes ovarian cancer proliferation, migration and invasion, but also acts on the peritoneum and contributes to metastasis of cancer in the form of cancer-derived exosomes." 1 Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription. - hsa_circ_ERBB2 - DOID:3121 gallbladder cancer gallbladder cancer RNA-seq up-regulated circERBB2 serves as an important regulator of cancer cell proliferation. 1 Upregulation Of circMMP9 Promotes Osteosarcoma Progression Via Targeting miR-1265/CHI3L1 Axis. - hsa_circ_MMP9 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circMMP9 contributes to OS development through the miR-1265/CHI3L1 pathway. 1 The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42. - hsa_circ_MLLT10 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq, microarray" up-regulated circMLLT10 acts as a miR-509-3-5p sponge to attenuate its repressive effect on target GINS4. 1 Circ_0006332 promotes growth and progression of bladder cancer by modulating MYBL2 expression via miR-143. hsa_circ_0006332 - circ_0006332 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated circ_0006332 promotes the growth and progression of bladder cancer by modulating MYBL2 expression by acting as a sponge for miR-143. 1 "Circ_0071662, a novel tumor biomarker, suppresses bladder cancer cell proliferation and invasion by sponging miR-146b-3p." hsa_circ_0071662 - circ_0071662 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated circ_0071662 suppresses bladder cancer cell proliferation and invasion by sponging miR-146b-3p. 1 Circ_0001658 promotes the proliferation and metastasis of osteosarcoma cells via regulating miR-382-5p/YB-1 axis. hsa_circ_0001658 - circ_0001658 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circ_0001658 promotes the proliferation and metastasis of OS cells via modulating miR-382-5p/YB-1 axis. 1 Silencing circular RNA VANGL1 inhibits progression of bladder cancer by regulating miR-1184/IGFBP2 axis. - hsa_circ_VANGL1 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated circVANGL1 acts as a tumor promoter through the novel circVANGL1/miR-1184/IGFBP2 axis. 3 Circ-TCF4.85 silencing inhibits cancer progression through microRNA-486-5p-targeted inhibition of ABCF2 in hepatocellular carcinoma. - hsa_circ_TCF4.85 circ-TCF4.85 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated our results reveal that silencing of circ-TCF4.85 suppresses HCC progression via miR-486-5p-targeted inhibition of ABCF2. 1 The expression profile of circRNA and its potential regulatory targets in the placentas of severe pre-eclampsia. hsa_circ_0001438 hsa_circ_LARP1B - DOID:10591 pre-eclampsia preeclampsia RNA-seq up-regulated "hsa_circ_0001438, hsa_circ_0001326, and hsa_circ_32340 were upregulated in the sPE patients." 1 The expression profile of circRNA and its potential regulatory targets in the placentas of severe pre-eclampsia. hsa_circ_0001326 hsa_circ_PHLDB2 - DOID:10591 pre-eclampsia preeclampsia RNA-seq up-regulated "hsa_circ_0001438, hsa_circ_0001326, and hsa_circ_32340 were upregulated in the sPE patients." 2 The expression profile of circRNA and its potential regulatory targets in the placentas of severe pre-eclampsia. - - hsa_circ_32340 DOID:10591 pre-eclampsia preeclampsia RNA-seq up-regulated "hsa_circ_0001438, hsa_circ_0001326, and hsa_circ_32340 were upregulated in the sPE patients." 1 CircLMTK2 acts as a tumor suppressor in prostate cancer via regulating the expression of microRNA-183. - hsa_circ_LMTK2 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated circLMTK2 overexpression exerts an anti-tumor effects through down-regulating the expression of miR-183. 1 Characterization of a Prostate- and Prostate Cancer-Specific Circular RNA Encoded by the Androgen Receptor Gene. - hsa_circ_AR3 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated Our results demonstrated that the origin of the detectable plasma circAR3 is from the prostate/PCa. Plasma circAR3 may be developed to be a PCa biomarker to monitor PCa development and tumor progression. 1 Circular RNA circDLGAP4 exerts neuroprotective effects via modulating miR-134-5p/CREB pathway in Parkinson disease. - hsa_circ_DLGAP4 - DOID:14330 Parkinson disease Parkinson disease RT-qPCR up-regulated circDLGAP4 exerts neuroprotective effects via modulating miR-134-5p/CREB pathway both in human and mouse. 1 CircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1. - hsa_circ_ENO1 circRNA-ENO1 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated circ-ENO1 promoted glycolysis and tumor progression in LUAD by miR-22-3p/ENO1 axis. 1 Circular RNA hsa_circ_0000515 acts as a miR-326 sponge to promote cervical cancer progression through up-regulation of ELK1. hsa_circ_0000515 hsa_circ_RPPH1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated hsa_circ_0000515 acts as a tumor promoter in cervical cancer. 2 Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New-Onset Rheumatoid Arthritis. hsa_circ_0002715 hsa_circ_PCNT - DOID:7148 rheumatoid arthritis new-onset rheumatoid arthritis RT-qPCR up-regulated the combination of hsa_circ_0002715 and hsa_circ_0035198 in peripheral blood may be a potential biomarker of patients with new-onset RA. 1 Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New-Onset Rheumatoid Arthritis. hsa_circ_0035198 hsa_circ_ATP8B4 - DOID:7148 rheumatoid arthritis new-onset rheumatoid arthritis RT-qPCR up-regulated the combination of hsa_circ_0002715 and hsa_circ_0035198 in peripheral blood may be a potential biomarker of patients with new-onset RA. 1 Identification of non-coding RNA regulatory networks in pediatric acute myeloid leukemia reveals circ-0004136 could promote cell proliferation by sponging miR-142. hsa_circ_0004136 - circ-0004136 DOID:70323 childhood acute myeloid leukemia pediatric acute myeloid leukemia "RT-qPCR, RNA-seq" up-regulated Circ-0004136 was significantly upregulated in pediatric AML and could promote cell proliferation by sponging miR-142. 1 Circular RNA circ-PRKCI promotes cell proliferation and invasion by binding to microRNA-545 in gastric cancer. - hsa_circ_PRKCI circ-PRKCI DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ-PRKCI can be used as a potential prognostic indicator of GC. 3 Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145-5p expression. - hsa_circ_ZNF609 circ-ZNF609 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ-ZNF609 promotes proliferative and invasive abilities of gastric cancer cells by inhibiting miRNA-145-5p expression as a ceRNA. 1 Circ_0000064 adsorption of microRNA-143 promotes malignant progression of hepatocellular carcinoma. hsa_circ_0000064 - circ_0000064 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ_0000064 level was remarkably upregulated in hepatocellular carcinoma and was associated with high pathological stage and poor prognosis of patients. 1 Circular RNA circ_0067934 functions as an oncogene in breast cancer by targeting Mcl-1. hsa_circ_0067934 - circ_0067934 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circ_0067934 enhances BC cell proliferation and regulates BC cell cycle via upregulating Mcl-1. 1 CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia. hsa_circ_0058058 hsa_circ_ATIC - DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" up-regulated "qRT-PCR analysis was performed on 6 randomly selected differentially expressed circRNAs, including 3 up-regulated circRNAs (hsa_circ_0058058, hsa_circ_0008045 and hsa_circ_0023313) and 3 down-regulated circRNAs (hsa_circ_0061817, hsa_circ_0002023, and hsa_circ_0008533) in control and NOA group testicular tissue samples." 1 CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia. hsa_circ_0008045 hsa_circ_MGLL - DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" up-regulated "qRT-PCR analysis was performed on 6 randomly selected differentially expressed circRNAs, including 3 up-regulated circRNAs (hsa_circ_0058058, hsa_circ_0008045 and hsa_circ_0023313) and 3 down-regulated circRNAs (hsa_circ_0061817, hsa_circ_0002023, and hsa_circ_0008533) in control and NOA group testicular tissue samples." 1 CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia. hsa_circ_0023313 hsa_circ_PPFIA1 - DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" up-regulated "qRT-PCR analysis was performed on 6 randomly selected differentially expressed circRNAs, including 3 up-regulated circRNAs (hsa_circ_0058058, hsa_circ_0008045 and hsa_circ_0023313) and 3 down-regulated circRNAs (hsa_circ_0061817, hsa_circ_0002023, and hsa_circ_0008533) in control and NOA group testicular tissue samples." 1 CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia. hsa_circ_0061817 hsa_circ_C2CD2 - DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" down-regulated "qRT-PCR analysis was performed on 6 randomly selected differentially expressed circRNAs, including 3 up-regulated circRNAs (hsa_circ_0058058, hsa_circ_0008045 and hsa_circ_0023313) and 3 down-regulated circRNAs (hsa_circ_0061817, hsa_circ_0002023, and hsa_circ_0008533) in control and NOA group testicular tissue samples." 1 CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia. hsa_circ_0002023 hsa_circ_CDC25A - DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" down-regulated "qRT-PCR analysis was performed on 6 randomly selected differentially expressed circRNAs, including 3 up-regulated circRNAs (hsa_circ_0058058, hsa_circ_0008045 and hsa_circ_0023313) and 3 down-regulated circRNAs (hsa_circ_0061817, hsa_circ_0002023, and hsa_circ_0008533) in control and NOA group testicular tissue samples." 1 CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia. hsa_circ_0008533 hsa_circ_CLTCL1 - DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" down-regulated "qRT-PCR analysis was performed on 6 randomly selected differentially expressed circRNAs, including 3 up-regulated circRNAs (hsa_circ_0058058, hsa_circ_0008045 and hsa_circ_0023313) and 3 down-regulated circRNAs (hsa_circ_0061817, hsa_circ_0002023, and hsa_circ_0008533) in control and NOA group testicular tissue samples." 1 CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression. - - circRNA-5692 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated circRNA-5692-miR-328-5p-DAB2IP regulatory pathway inhibits the progression of HCC. 1 CircDUSP16 promotes the tumorigenesis and invasion of gastric cancer by sponging miR-145-5p. - hsa_circ_DUSP16 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircDUSP16 facilitates the tumorigenesis and invasion of GC cells by sponging miR-145-5p. 1 Circ-TFCP2L1 Promotes the Proliferation and Migration of Triple Negative Breast Cancer through Sponging miR-7 by Inhibiting PAK1. - hsa_circ_TFCP2L1 circ-TFCP2L1 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, RNA-seq" up-regulated circ-TFCP2L1 was identified as a sponge of miR-7 functionally targeting PAK1 and further promoting the proliferation and migration of TNBC cells. 1 Hsa_circ_0046159 is involved in the development of chronic thromboembolic pulmonary hypertension. hsa_circ_0046159 hsa_circ_NPLOC4 - DOID:6432 pulmonary hypertension pulmonary hypertension "RT-qPCR, RNA-seq" up-regulated Hsa_circ_0046159 is involved in the development of chronic thromboembolic pulmonary hypertension. 1 Identification of urinary hsa_circ _0137439 as potential biomarker and tumor regulator of bladder cancer. hsa_circ_0137439 hsa_circ_MTDH - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated urinary cell-free hsa_circ_0137439 could be a promising biomarker for tumor diagnosis and prognostic assessment of bladder cancer patients. 1 Circular RNA hsa_circ_0000654 promotes esophageal squamous cell carcinoma progression by regulating the miR-149-5p/IL-6/STAT3 pathway. hsa_circ_0000654 hsa_circ_CHD2 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated circ_0000654 functions as an oncogenic circRNA in ESCC and accelerates ESCC progression via adsorbing miR-149-5p and activating the IL-6/STAT3 signaling pathway. 2 Suppression of circDcbld1 Alleviates Intimal Hyperplasia in Rat Carotid Artery by Targeting miR-145-3p/Neuropilin-1. - rno_circ_Dcbld1 - DOID:13001 carotid stenosis carotid stenosis "RT-qPCR, RNA-seq" up-regulated Suppression of circDcbld1 Alleviates Intimal Hyperplasia in Rat Carotid Artery by Targeting miR-145-3p/Neuropilin-1. 1 circASXL1-1 regulates BAP1 deubiquitinase activity in leukemia. - hsa_circ_ASXL1-1 - DOID:1073 renal hypertension hypertensive renal injury "RT-qPCR, RNA-seq" up-regulated circNr1h4 acts as a competing endogenous RNA for miR-155-5p and then regulates its target gene Far1. 1 CircNr1h4 regulates the pathological process of renal injury in salt-sensitive hypertensive mice by targeting miR-155-5p. - mmu_circ_Nr1h4 - DOID:10763 hypertension hypertension "RT-qPCR, RNA-seq" down-regulated "the silencing of circNr1h4 or overexpression of miR-155-5p significantly decreased Far1 levels and increased reactive oxygen species. Mechanistic investigations indicated that circNr1h4 acts as a competing endogenous RNA for miR-155-5p, leading to regulation of its target gene Far1. " 1 Circular RNA hsa_circ_001895 serves as a sponge of microRNA-296-5p to promote clear cell renal cell carcinoma progression by regulating SOX12. - - hsa_circ_001895 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated hsa_circ_001895 may sponge miR_296_5p and promote SOX12 expression. 1 Hsa_circ_0000285 functions as a competitive endogenous RNA to promote osteosarcoma progression by sponging hsa-miRNA-599. hsa_circ_0000285 hsa_circ_HIPK3 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circ-0000285 overexpression enhanced the proliferative and migratory potentials of osteosarcoma. 4 Lung myofibroblast transition and fibrosis is regulated by circ0044226. hsa_circ_0044226 - circ0044226 DOID:0050156 idiopathic pulmonary fibrosis idiopathic pulmonary fibrosis RT-qPCR up-regulated Circ0044226 knockdown alleviates fibroblast proliferation and FMT by functioning as a competing endogenous RNA. 1 "Comprehensive analysis of the regulatory network of differentially expressed mRNAs, lncRNAs and circRNAs in gastric cancer." hsa_circ_0058819 hsa_circ_COL6A3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "hsa_circ_0058819, hsa_circ_0058830 were significantly up-regulated in GC compared to match normal samples, which was consistent with microarray analysis." 3 "Comprehensive analysis of the regulatory network of differentially expressed mRNAs, lncRNAs and circRNAs in gastric cancer." hsa_circ_0058830 hsa_circ_COL6A3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "hsa_circ_0058819, hsa_circ_0058830 were significantly up-regulated in GC compared to match normal samples, which was consistent with microarray analysis." 3 hsa_circRNA_100873 upregulation is associated with increased lymphatic metastasis of esophageal squamous cell carcinoma. - - hsa_circRNA_100873 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated hsa_circRNA_100873 may be associated with increased lymphatic metastases in ESCC. 1 Circular RNA circ-PVT1 contributes to paclitaxel resistance of gastric cancer cells through the regulation of ZEB1 expression by sponging miR-124-3p. hsa_circ_0085553 hsa_circ_PVT1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circ-PVT1 facilitated PTX resistance by up-regulating ZEB1 mediated via miR-124-3p. 6 Genetic variants in circTUBB interacting with smoking can enhance colorectal cancer risk. - hsa_circ_TUBB - DOID:9256 colorectal cancer colorectal cancer RNA-seq up-regulated rs25497 in circTUBB was significantly associated with colorectal cancer risk in a Chinese population. 1 A novel circRNA-miRNA-mRNA network identifies circ-YOD1 as a biomarker for coronary artery disease. - hsa_circ_YOD1 circ-YOD1 DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, microarray" up-regulated Our investigation of the triple regulatory networks of circRNA-miRNA-mRNA in CAD revealed circ-YOD1 as a potential biomarker for CAD. 1 Hsa_circ_0051079 functions as an oncogene by regulating miR-26a-5p/TGF-beta1 in osteosarcoma. hsa_circ_0051079 hsa_circ_AKT2 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated The study demonstrated that circ_0051079 could act as an oncogene via regulating miR-26a-5p/TGF-beta1 and a potential biomarker for osteosarcoma diagnose. 3 Circ-DB participates in the progression of gastric cancer by competitively binding microRNA-34a to regulate the expression of MET. - hsa_circ_DB circ-DB DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ-DB may regulate MET level through microRNA-34a and affect the proliferative ability and migration of GCa cells. 1 Circular RNA_LARP4 inhibits cell proliferation and invasion of nasopharyngeal carcinoma by repressing ROCK1. - hsa_circ_LARP4 circular RNA_LARP4 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR down-regulated Circular RNA_LARP4 inhibits cell proliferation and invasion of nasopharyngeal carcinoma by repressing ROCK1. 1 Circular RNA circ-SMAD7 promoted glioma cell proliferation and metastasis by upregulating PCNA. - hsa_circ_SMAD7 circ-SMAD7 DOID:0060108 brain glioma glioma RT-qPCR up-regulated Our study suggests that circ-SMAD7 promotes proliferation and metastasis of glioma via upregulating PCNA. Circ-SMAD7/ PCNA might be a novel therapeutic strategy in glioma. 1 CircHIPK3 aggravates myocardial ischemia-reperfusion injury by binding to miRNA-124-3p. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:1287 cardiovascular system disease myocardial ischemia-reperfusion injury RT-qPCR up-regulated "CircHIPK3 inhibits proliferative ability and induces apoptosis of cardiomyocytes after myocardial I/R injury by binding to miRNA-124-3p, which may serve as a potential therapeutic target for I/R." 2 Circ_KATNAL1 regulates prostate cancer cell growth and invasiveness through the miR-145-3p/WISP1 pathway. - hsa_circ_KATNAL1 circ_KATNAL1 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Both circ_KATNAL1 and miR-145-3p inhibit cell proliferation, invasiveness, and migration, down-regulate the expression of MMP-2 and MMP-9, promote cell apoptosis and the activation of caspase-3, caspase-8, caspase-9, and PARP, whereas WISP1 has the opposite effect, and the above-mentioned functions of circ_KATNAL1 were achieved through the miR-145-3p/WISP1 pathway." 2 Circular RNA circ-Foxo3 induced cell apoptosis in urothelial carcinoma via interaction with miR-191-5p. - hsa_circ_FOXO3 circ-Foxo3 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circ-Foxo3 was downregulated in bladder cancer in vivo and in vitro, and promoted bladder cancer apoptosis via direct interaction with miR-191." 2 hsa_circ_0007841: A Novel Potential Biomarker and Drug Resistance for Multiple Myeloma. hsa_circ_0007841 hsa_circ_SEC61A1 - DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated "The results show that in the MM cell lines and drug-resistant cell lines, hsa_circ_0007841 expression was significantly upregulated, which was closely associated with disease prognosis." 5 Emerging Roles Of hsa-circ-0046600 Targeting The miR-640/HIF-1alpha Signalling Pathway In The Progression Of HCC. hsa_circ_0046600 hsa_circ_B3GNTL1 hsa-circ-0046600 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated hsa-circ-0046600 can be used as a new biomarker for HCC diagnosis and disease progression and provides a potential target for targeted therapy. 2 circ_0003418 Inhibits Tumorigenesis And Cisplatin Chemoresistance Through Wnt/beta-Catenin Pathway In Hepatocellular Carcinoma. hsa_circ_0003418 - circ_0003418 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ-0003418 exerts an antitumorigenic role in HCC and advances the sensitivity of HCC cells to cisplatin by restraining the Wnt/beta-catenin pathway. 2 circ5912 suppresses cancer progression via inducing MET in bladder cancer. - - circ5912 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated Our study firstly demonstrate that circ5912 regulates mesenchymal-to epithelial transition pathway to suppress bladder cancer progression and propose new therapeutic targets and biomarkers for bladder cancer. 1 Overexpression of circular RNA hsa_circ_0001038 promotes cervical cancer cell progression by acting as a ceRNA for miR-337-3p to regulate cyclin-M3 and metastasis-associated in colon cancer 1 expression. hsa_circ_0001038 hsa_circ_POLR1A - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated hsa_circ_0001038 plays an oncogenic role in CC cells partly by activating CNNM3 and MACC1. 1 Circular RNA ADAM9 facilitates the malignant behaviours of pancreatic cancer by sponging miR-217 and upregulating PRSS3 expression. - hsa_circ_ADAM9 - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated the ceRNA regulatory network of circ-ADAM9/miR-217/PRSS3 plays a pivotal role in PC progression by the regulation of ERK/VEGF signalling pathway. 1 Clinical significance of hsa_circ_0000419 in gastric cancer screening and prognosis estimation. hsa_circ_0000419 hsa_circ_RAB3IP - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Bioinformatics analysis showed that hsa_circ_0000419 involved in gastric tumorigenesis and progression via its interaction with microRNAs. 1 CircMYC Regulates Glycolysis and Cell Proliferation in Melanoma. - hsa_circ_MYC - DOID:1909 melanoma melanoma RT-qPCR up-regulated "present study revealed that 3 UTR of LDHA acted as a target of miR-1236 using Mel-CV cells. Based on our findings, c-MYC-SRSF1 axis may regulate the production of circMYC." 1 Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis. - hsa_circ_RANGAP1 circ-RanGAP1 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis. 1 circAMOTL1 Motivates AMOTL1 Expression to Facilitate Cervical Cancer Growth. - hsa_circ_AMOTL1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circAMOTL1 served as a competing endogenous RNA (ceRNA) to prompt the expression of AMOTL1 through sponging miR-485-5p. 3 Downregulated Circular RNA hsa_circ_0000291 Suppresses Migration And Proliferation Of Gastric Cancer Via Targeting The miR-183/ITGB1 Axis. hsa_circ_0000291 hsa_circ_CD44 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated hsa_circ_0000291 knockdown inhibited GC cell metastasis and growth by regulating the miR-183/ITGB1 axis. 2 Hypoxia-induced circular RNA has_circRNA_403658 promotes bladder cancer cell growth through activation of LDHA. - hsa_circ_ZNF292 has-circRNA-403658 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "We demonstrated that has-circRNA-403658 was an important circRNA that upregulated in bladder cancer cells under hypoxia, and higher has-circRNA-403658 levels were associated with poorer survival outcome." 1 Identification of Circular RNAs Regulating Islet beta-Cell Autophagy in Type 2 Diabetes Mellitus. - - rno_circRNA_008565 DOID:9352 type 2 diabetes mellitus type 2 diabetes mellitus RT-qPCR up-regulated "We speculate that these circRNAs, especially rno_circRNA_008565, can regulate the autophagy of islet beta-cells via interactions with miRNA. Dysregulation of several circRNAs may play a role in T2DM development, and rno_circRNA_008565 may be a potential regulator of beta-cell autophagy." 1 Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells. - hsa_circ_FGFR1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "our results suggest the critical role of circFGFR1 in the proliferation, migration, invasion, and immune evasion abilities of NSCLC cells and provide a new perspective on circRNAs during NSCLC progression." 1 [Expression of circular RNA hsa_circ_0014130 in lung adenocarcinoma cell lines and its effect on proliferation and invasion of lung adenocarcinoma cell line]. hsa_circ_0014130 hsa_circ_PIP5K1A - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "The hsa_circ_0014130 promotes the invasion and proliferation of lung cancer cells by targeting hsa-miR-566 to enhance the expression of TWIST1, and its expression level can be significantly inhibited by the small molecule inhibitor SB-431542, which significantly inhibits the proliferation and invasion of lung cancer cells. Therefore,hsa_circ_0014130 is a potential lung cancer treatment target." 1 ciRs-6 upregulates March1 to suppress bladder cancer growth by sponging miR-653. hsa_circ_0006260 hsa_circ_SLC41A2 ciRs-6 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated Our study identifies an oncogenic role of ciRs-6 and suggests its usefulness as a novel biomarker for bladder cancer diagnosis and prognosis and as a therapeutic target for bladder cancer. 1 Posttranscriptional regulation of AKT by circular RNA angiomotin- like 1 mediates chemoresistance against paclitaxel in breast cancer cells. - hsa_circ_AMOTL1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circAMOTL1 may play an important role in the PAX resistance of breast cancer cells via regulation of AKT pathway, facilitation of anti-apoptotic protein and inhibition of pro-apoptotic protein." 2 circ-MYBL2 Serves As A Sponge For miR-361-3p Promoting Cervical Cancer Cells Proliferation And Invasion. - hsa_circ_MYBL2 circ-MYBL2 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Our findings suggested that circ-MYBL2 promoted CC progression by regulating miR-361-3p expression, which provided a novel therapeutic target for the treatment of CC patients." 2 CircCDYL Serves as a New Biomarker in Mantle Cell Lymphoma and Promotes Cell Proliferation. - hsa_circ_CDYL - DOID:0050746 mantle cell lymphoma mantle cell lymphoma RT-qPCR up-regulated circ-CDYL might serve as a potential diagnostic biomarker in clinical practice. 1 CircPTPRA acts as a tumor suppressor in bladder cancer by sponging miR-636 and upregulating KLF9. - hsa_circ_PTPRA - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circPTPRA acts as a tumor suppressor in BC, and suggests that this circRNA may be a novel prognostic biomarker and therapeutic target in BC." 1 Circ_0001955 facilitates hepatocellular carcinoma (HCC) tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11. hsa_circ_0001955 - circ_0001955 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ_0001955 facilitated HCC tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11 expression. 5 "Microarray expression profiles and bioinformatics analysis of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma." hsa_circ_0043949 hsa_circ_BRCA1 - DOID:3073 brain glioblastoma multiforme glioblastoma microarray up-regulated "Our findings revealed the alteration of expression patterns of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma for the first time. NONHSAT163779 and hsa_circ_0043949 might be potential therapeutic targets and prognostic biomarkers for the treatment of glioblastoma." 2 Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "CircITCH promoted prostate cancer progression by regulating the HOXB13/miR-17-5p axis, and circITCH have a potential usage as therapeutic target for PC tumors." 2 Downregulated Expression of hsa_circ_0005556 in Gastric Cancer and Its Clinical Significance. hsa_circ_0005556 hsa_circ_NBAS - DOID:10534 stomach cancer gastric cancer RNA-seq up-regulated "hsa_circ_0005556 is a potential biomarker for GC, which may guide judgment of the indication of endoscopic treatment for early gastric cancer (EGC)." 3 Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. hsa_circ_0140628 - - DOID:10159 osteonecrosis steroid-induced osteonecrosis of the femoral head "RT-qPCR, RNA-seq" up-regulated This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH. 1 Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. hsa_circ_0097391 - - DOID:10159 osteonecrosis steroid-induced osteonecrosis of the femoral head "RT-qPCR, RNA-seq" up-regulated This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH. 1 Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. hsa_circ_0058919 hsa_circ_NDUFA10 - DOID:10159 osteonecrosis steroid-induced osteonecrosis of the femoral head "RT-qPCR, RNA-seq" up-regulated This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH. 1 Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. hsa_circ_0002737 hsa_circ_SARNP - DOID:10159 osteonecrosis steroid-induced osteonecrosis of the femoral head "RT-qPCR, RNA-seq" up-regulated This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH. 1 Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. hsa_circ_0004692 hsa_circ_SETD2 - DOID:10159 osteonecrosis steroid-induced osteonecrosis of the femoral head "RT-qPCR, RNA-seq" up-regulated This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH. 1 Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. hsa_circ_0000069 hsa_circ_STIL - DOID:10159 osteonecrosis steroid-induced osteonecrosis of the femoral head "RT-qPCR, RNA-seq" up-regulated This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH. 1 Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. hsa_circ_0003344 hsa_circ_TMCC2 - DOID:10159 osteonecrosis steroid-induced osteonecrosis of the femoral head "RT-qPCR, RNA-seq" up-regulated This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH. 1 Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. hsa_circ_0093677 hsa_circ_ZFAND4 - DOID:10159 osteonecrosis steroid-induced osteonecrosis of the femoral head "RT-qPCR, RNA-seq" up-regulated This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH. 1 Elevated serum circ_0068481 levels as a potential diagnostic and prognostic indicator in idiopathic pulmonary arterial hypertension. hsa_circ_0068481 - circ_0068481 DOID:14557 primary pulmonary hypertension idiopathic pulmonary arterial hypertension RT-qPCR up-regulated Circ_0068481 is a novel and noninvasive biomarker for diagnosing idiopathic pulmonary arterial hypertension and predicting poor clinical outcome in patients with idiopathic pulmonary arterial hypertension. 1 Microarray Analysis For Expression Profiles of lncRNAs and circRNAs in Rat Liver after Brain-Dead Donor Liver Transplantation. - - rno_circRNA_007609 DOID:409 liver disease donor liver transplantation "RT-qPCR, microarray" up-regulated These results suggest that lncRNAs and circRNAs play important roles in the pathogenesis and development of liver injury during BDDLT. 1 circCDYL/microRNA-105-5p participates in modulating growth and migration of colon cancer cells. - hsa_circ_CDYL - DOID:219 colon cancer colon cancer RT-qPCR up-regulated circCDYL overexpression repressed cellular growth and migration via repressing miR-150-5p in colon cancer cells. 1 The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression. - hsa_circ_CLK3 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circCLK3 may serve as a novel diagnostic biomarker for disease progression and a promising molecular target for early diagnoses and treatments of cervical cancer. 1 Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer disease patients. - - hsa_circRNA_103366 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "QRT-PCR is performed to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015." 1 Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer disease patients. - - hsa_circRNA_103936 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "QRT-PCR is performed to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015." 1 Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer disease patients. - - hsa_circRNA_101618 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "QRT-PCR is performed to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015." 1 Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer disease patients. - - hsa_circRNA_405619 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "QRT-PCR is performed to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015." 1 Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer disease patients. - - hsa_circRNA_000843 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "QRT-PCR is performed to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015." 1 Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer disease patients. - - hsa_circRNA_104395 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "QRT-PCR is performed to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015." 1 Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer disease patients. - - hsa_circRNA_402904 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "QRT-PCR is performed to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015." 1 Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer disease patients. - - hsa_circRNA_403472 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "QRT-PCR is performed to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015." 1 Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis. - hsa_circ_ASAP1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated We identified circASAP1 as a key regulator of HCC metastasis that acts on miR-326/miR-532-5p-MAPK1/CSF-1 signaling and serves as a prognostic predictor in patients with HCC. 3 RNA Sequencing Reveals a Comprehensive Circular RNA Expression Profile in a Mouse Model of Alcoholic Liver Disease. - - mou_circ_1657 DOID:12351 alcoholic hepatitis alcoholic liver disease "RT-qPCR, RNA-seq" up-regulated This study demonstrates that a cluster of circRNAs is aberrantly expressed in the livers of ALD mice. mou_circ_1657/miR-19-5b may play a critical role in the development of ALD. Our study provides new insight into the future investigation and therapy on ALD. 1 Circ_0091579 promotes proliferative ability and metastasis of liver cancer cells by regulating microRNA-490-3p. hsa_circ_0091579 - circ_0091579 DOID:3571 liver cancer liver cancer RT-qPCR up-regulated "circ_0091579 is abnormally highly expressed in LCa tissues and cells. Down-regulation of circ_0091579 can inhibit the proliferative ability and metastasis of HCC cells by regulating microRNA-490-3p, thus accelerating the progress of the tumor." 1 Effect of circ MTHFD2 on resistance to pemetrexed in gastric cancer through regulating expression of miR-124. - hsa_circ_MTHFD2 circ MTHFD2 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Circ MTHFD2 directly binds to miR-124 through the molecular sponge effect. This may induce increased protein expression of MDR-1, ultimately enhancing the drug resistance of MGC-803/MTA cells." 1 Circ_0001742 promotes tongue squamous cell carcinoma progression via miR-431-5p/ATF3 axis. hsa_circ_0001742 - circ_0001742 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma RT-qPCR up-regulated "Our results demonstrated that circ_0001742 plays a tumor-promoting effect in TSCC cells by serving as a competing endogenous RNA (ceRNA) to regulate miR-431-5p/ATF3 axis, which might provide a potential therapeutic target for TSCC." 4 Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p. hsa_circ_0002483 hsa_circ_PTK2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p. 3 CircRNA-UCK2 Increased TET1 Inhibits Proliferation and Invasion of Prostate Cancer Cells Via Sponge MiRNA-767-5p. - hsa_circ_UCK2 circRNA-UCK2 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated CircRNA-UCK2 Increased TET1 Inhibits Proliferation and Invasion of Prostate Cancer Cells Via Sponge MiRNA-767-5p. 1 Circ_0000267 promotes gastric cancer progression via sponging MiR-503-5p and regulating HMGA2 expression. hsa_circ_0000267 - circ_0000267 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Circ_0000267 is an oncogenic circRNA that affects the progression of GC, which participates in promotion of GC proliferation, migration, invasion, and EMT via modulating the miR-503-5p/HMGA2 axis." 1 Androgen receptor reverses the oncometabolite R-2-hydroxyglutarate-induced prostate cancer cell invasion via suppressing the circRNA-51217/miRNA-646/TGFbeta1/p-Smad2/3 signaling. - - circRNA-51217 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated This study demonstrates that IDH1 R132H mutation with increased oncometabolite R-2HG in PCa cells may play important roles to increase PCa cell invasion. 1 CircRNA_100367 regulated the radiation sensitivity of esophageal squamous cell carcinomas through miR-217/Wnt3 pathway. - - circRNA_100367 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated Our results revealed that circRNA_100367 attenuated radioresistance of ESCC through miR-217/Wnt3 pathway. 1 [CircRNA_005647 inhibits expressions of fibrosis-related genes in mouse cardiac fibroblasts via sponging miR-27b-3p]. - - circRNA_005647 DOID:114 heart disease cardiac fibrosis RT-qPCR up-regulated CircRNA_005647 is upregulated in cardiac fibrosis and inhibits the expression of fibrosis-related genes through sponging miR-27b-3p in mouse CFs. 1 CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1. - hsa_circ_AHNAK1 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated CircAHNAK1 inhibits proliferation and metastasis of TNBC by modulating miR-421 and RASA1. 1 hsa_circ_0006459 and hsa_circ_0015962 affect prognosis of Dengue fever. hsa_circ_0006459 hsa_circ_GNAQ - DOID:12205 dengue disease dengue fever RT-qPCR up-regulated Downregulation of hsa_circ_0006459 and upregulation of hsa_circ_0015962 affect the treatment response of DF and are potential biomarkers in DF patients. The molecular mechanism involves hsa_circ_0006459-mediated targeted negative regulation of miR-133b and hsa_circ_0015962-mediated targeted negative regulation of miR-4683. 1 hsa_circ_0006459 and hsa_circ_0015962 affect prognosis of Dengue fever. hsa_circ_0015962 hsa_circ_RNPEP - DOID:12205 dengue disease dengue fever RT-qPCR up-regulated Downregulation of hsa_circ_0006459 and upregulation of hsa_circ_0015962 affect the treatment response of DF and are potential biomarkers in DF patients. The molecular mechanism involves hsa_circ_0006459-mediated targeted negative regulation of miR-133b and hsa_circ_0015962-mediated targeted negative regulation of miR-4683. 1 Circ-0003998 promotes cell proliferative ability and invasiveness by binding to miR-197-3p in osteosarcoma. hsa_circ_0003998 - circ-0003998 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ-0003998 plays a vital role in promoting the development of osteosarcoma, whose high expression can predict poor clinical prognosis. Circ-0003998 is highly expressed in osteosarcoma tissues and cell lines. The down-regulation of its level can significantly inhibit the proliferative ability and invasiveness of osteosarcoma cells. Meanwhile, circ-0003998 up-regulates the expression of KLF10 by binding to miR-197-3p, thereby promoting osteosarcoma cell growth and invasion, and accelerating the progression of osteosarcoma." 1 Circular RNA hsa_circ_0000285 acts as an oncogene in laryngocarcinoma by inducing Wnt/beta-catenin signaling pathway. hsa_circ_0000285 hsa_circ_HIPK3 - DOID:2600 laryngeal carcinoma laryngeal cancer RT-qPCR up-regulated Circular RNA hsa_circ_0000285 acts as an oncogene in laryngocarcinoma by inducing Wnt/beta-catenin signaling pathway. 1 "Circular RNA circ_0067934 exhaustion expedites cell apoptosis and represses cell proliferation, migration and invasion in thyroid cancer via sponging miR-1304 and regulating CXCR1 expression." hsa_circ_0067934 - circ_0067934 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "Circ_0067934 downregulation expedited apoptosis and retarded proliferation, migration, and invasion of TC cells through miR-1304/CXCR1 axis." 2 "Circ-0001801 contributes to cell proliferation, migration, invasion and epithelial to mesenchymal transition (EMT) in glioblastoma by regulating miR-628-5p/HMGB3 axis." hsa_circ_0001801 - circ-0001801 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "Overexpression of circ-00018 01 accelerates cell proliferation, migration, invasion and EMT in GBM by absorbing miR-628-5p and facilitating HMGB3 expression, representing promising targeted therapy for GBM." 1 Circular RNA TTBK2 promotes the development of human glioma cells via miR-520b/EZH2 axis. - hsa_circ_TTBK2 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Circ-TTBK2/miR-520b/EZH2 axis modulated cell proliferation, apoptosis, and invasion in glioma cell lines, and might serve as potential targets for glioma diagnosis and therapy." 4 CircRNA_0016418 expedites the progression of human skin melanoma via miR-625/YY1 axis. hsa_circ_0016418 - circRNA_0016418 DOID:8923 skin melanoma skin melanoma RT-qPCR up-regulated "Circ0016418 regulated proliferation, migration, invasion, and EMT of skin melanoma cells through miR-625/YY1 axis. Circ0016418 might be a useful indicator of the therapeutic strategies of skin melanoma." 1 circCCT3 Modulates Vascular Endothelial Growth Factor A and Wnt Signaling to Enhance Colorectal Cancer Metastasis Through Sponging miR-613. - hsa_circ_CCT3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "we propose that circCCT3 contributes to CRC metastasis via miR-613/WNT3 or miR-613/VEGFA, promoting the development of therapeutical approaches for treating CRC." 2 Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice. - - circular RNA NF1-419 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated These findings provide novel insights into circNF1-419 and its potential usefulness for the diagnosis and treatment of dementia by regulating Dynamin-1 and AP2B1 mediated autophagy. 1 Biosynthetic CircRNA_001160 induced by PTBP1 regulates the permeability of BTB via the CircRNA_001160/miR-195-5p/ETV1 axis. - - circRNA_001160 DOID:162 cancer blood-tumor barrier RT-qPCR up-regulated Biosynthetic CircRNA_001160 induced by PTBP1 regulates the permeability of BTB via the CircRNA_001160/miR-195-5p/ETV1 axis. 1 Circular RNA circ-CMPK1 contributes to cell proliferation of non-small cell lung cancer by elevating cyclin D1 via sponging miR-302e. - hsa_circ_CMPK1 circ-CMPK1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circular RNA circ-CMPK1 contributes to cell proliferation of non-small cell lung cancer by elevating cyclin D1 via sponging miR-302e. 1 CircACAP2 promotes breast cancer proliferation and metastasis by targeting miR-29a/b-3p-COL5A1 axis. - hsa_circ_ACAP2 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated CircACAP2 promotes breast cancer proliferation and metastasis by targeting miR-29a/b-3p-COL5A1 axis. 1 CircRNA104250 and lncRNAuc001dgp1 promote the PM(25)-induced inflammatory response by co-targeting miR-3607-5p in BEAS-2B cells. - - circRNA104250 DOID:850 lung disease airway inflammation "RT-qPCR, microarray" up-regulated CircRNA104250 and lncRNAuc001.dgp.1 promote the PM(2.5)-induced inflammatory response by co-targeting miR-3607-5p in BEAS-2B cells. 1 Circular METRN RNA hsa_circ_0037251 Promotes Glioma Progression by Sponging miR-1229-3p and Regulating mTOR Expression. hsa_circ_0037251 hsa_circ_METRN - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "These results indicated that hsa_circ_0037251 may act as a tumour promoter by a hsa_circ_0037251/miR-1229-3p/mTOR axis, and these potential biomarkers may be therapeutic targets for glioma." 1 Circular RNA HIPK3 contributes to hyperglycemia and insulin homeostasis by sponging miR-192-5p and upregulating transcription factor forkhead box O1. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:4195 hyperglycemia hyperglycemia and insulin homeostasis RT-qPCR up-regulated the present study demonstrated that circHIPK3 contributes to hyperglycemia and insulin resistance by sponging miR-192-5p and up-regulating FOXO1. 1 "Circular RNA SMARCA5 correlates with favorable clinical tumor features and prognosis, and increases chemotherapy sensitivity in intrahepatic cholangiocarcinoma." - hsa_circ_SMARCA5 - DOID:4928 intrahepatic cholangiocarcinoma intrahepatic cholangiocarcinoma. RT-qPCR up-regulated "The correlation of circ-SMARCA5 with favorable clinical tumor features, survival profile, and its promoting effect on chemotherapy sensitivity implies its potential as a valuable biomarker in monitoring disease progression and prognosis of ICC." 1 Hsa_circ_0006948 enhances cancer progression and epithelial-mesenchymal transition through the miR-490-3p/HMGA2 axis in esophageal squamous cell carcinoma. hsa_circ_0006948 hsa_circ_FNDC3B - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "In conclusion, hsa_circ_0006948 was overexpressed in ESCC tissues and promoted cancer progression, and it could induce EMT by enhancing HMGA2 by sponging miR-490-3p, suggesting that hsa_circ_0006948 could be a biomarker for ESCC." 4 Circular RNA CDR1-AS contributes to pemetrexed and cisplatin chemoresistance through EGFR/PI3K signaling pathway in lung adenocarcinoma. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "the CDR1-AS is high-expressed in LUAD and is an independent prognostic biomarker for LUAD patients. The high-expression of CDR1-AS is related with the PTX and CDDP insensitivity of LUAD patients, CDR1-AS promotes PTX and CDDP chemoresistance through EGFR/PI3K signaling pathway in LUAD." 2 Screening and identification of epithelial-to-mesenchymal transition-related circRNA and miRNA in prostate cancer. hsa_circ_0001165 hsa_circ_NCOA3 - DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated It was found that hsa_circ_0001165 may regulate TNF expression through hsa-miR-187-3p to induce EMT in prostate cancer cells. 1 Screening and identification of epithelial-to-mesenchymal transition-related circRNA and miRNA in prostate cancer. hsa_circ_0001085 hsa_circ_GLS - DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0001085 may indirectly regulate the PI3K-Akt signaling and TGF-beta signaling pathways through hsa-miR-196b-5p and the MAPK signaling pathway through has-miR-451a, which played a regulatory role in prostate cancer cells in the EMT induction model." 1 The potential of ciRS-7 for predicting onset and prognosis of cervical cancer. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "ciRS-7 possessed great potential in clinical diagnosis of CC, given its involvement in modulating the activity of CC cells." 1 "Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer." - hsa_circ_MDM2 circ_MDM2_000139 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RNA-seq up-regulated "Let-7 family members and POLR2A targeting circ_MDM2_000139, miR-16-5p/miR-134-5p targeting circ_ATF2_001418, miR-133b targeting circ_BIRC6_001271, and miR-221-3p/miR-222-3p targeting circ_CDC25C_002079 might be related to the mechanism in the treatment of NSCLC by XAV939." 1 "Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer." - hsa_circ_ATF2 circ_ATF2_001418 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RNA-seq up-regulated "Let-7 family members and POLR2A targeting circ_MDM2_000139, miR-16-5p/miR-134-5p targeting circ_ATF2_001418, miR-133b targeting circ_BIRC6_001271, and miR-221-3p/miR-222-3p targeting circ_CDC25C_002079 might be related to the mechanism in the treatment of NSCLC by XAV939." 1 "Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer." - hsa_circ_BIRC6 circ_BIRC6_001271 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RNA-seq up-regulated "Let-7 family members and POLR2A targeting circ_MDM2_000139, miR-16-5p/miR-134-5p targeting circ_ATF2_001418, miR-133b targeting circ_BIRC6_001271, and miR-221-3p/miR-222-3p targeting circ_CDC25C_002079 might be related to the mechanism in the treatment of NSCLC by XAV939." 5 "Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer." - hsa_circ_CDC25C circ_CDC25C_002079 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RNA-seq up-regulated "Let-7 family members and POLR2A targeting circ_MDM2_000139, miR-16-5p/miR-134-5p targeting circ_ATF2_001418, miR-133b targeting circ_BIRC6_001271, and miR-221-3p/miR-222-3p targeting circ_CDC25C_002079 might be related to the mechanism in the treatment of NSCLC by XAV939." 1 Exosomal circHIPK3 Released from Hypoxia-Pretreated Cardiomyocytes Regulates Oxidative Damage in Cardiac Microvascular Endothelial Cells via the miR-29a/IGF-1 Pathway. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:114 heart disease hypoxia-pretreated cardiomyocytes RT-qPCR up-regulated "circHIPK3 in HPC-exos plays a role in CMVECs under oxidative conditions through miR-29a-mediated IGF-1 expression, leading to a decrease in oxidative stress-induced CMVECs dysfunction. " 4 Bioinformatic Analysis of Circular RNA-Associated ceRNA Network Associated with Hepatocellular Carcinoma. hsa_circ_0009910 hsa_circ_MFN2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "The results suggested that hsa_circ_0009910, which was upregulated in HCC tissues, participates in the pathogenesis of HCC by acting as a sponge of miR-1261 to regulate the expression of UBE2L3." 3 CircNFIX promotes progression of glioma through regulating miR-378e/RPN2 axis. - hsa_circ_NFIX - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Knockdown of circNFIX inhibits progression of glioma in vitro and in vivo by increasing miR-378e and decreasing RPN2, providing a novel mechanism for understanding the pathogenesis of glioma." 2 Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy. - hsa_circ_DNAJC6 - DOID:11984 hypertrophic cardiomyopathy hypertrophic cardiomyopathy RT-qPCR up-regulated This is the first study indicating the abundancy of disease-relevant circulating circRNAs in HCM and highlighting the importance of a set of circRNAs as possible novel indicators of HCM. 1 Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy. - hsa_circ_MBOAT2 - DOID:11984 hypertrophic cardiomyopathy hypertrophic cardiomyopathy RT-qPCR up-regulated This is the first study indicating the abundancy of disease-relevant circulating circRNAs in HCM and highlighting the importance of a set of circRNAs as possible novel indicators of HCM. 1 Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy. - hsa_circ_TMEM56 - DOID:11984 hypertrophic cardiomyopathy hypertrophic cardiomyopathy RT-qPCR up-regulated This is the first study indicating the abundancy of disease-relevant circulating circRNAs in HCM and highlighting the importance of a set of circRNAs as possible novel indicators of HCM. 1 Knockdown of circular RNA circZNF652 remits LPS-induced inflammatory damage by regulating miR-181a. - hsa_circ_ZNF652 - DOID:10533 viral pneumonia infantile pneumonia RT-qPCR up-regulated Knockdown of circZNF652 remitted LPS-triggered WI-38 cells inflammatory damage through deactivation of NF-kB and JNK/p38pathways by up-regulating miR-181a. 3 Circular RNA ABCB10 promotes hepatocellular carcinoma progression by increasing HMG20A expression by sponging miR-670-3p. - hsa_circ_ABCB10 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circABCB10 promoted HCC progression by modulating the miR-670-3p/HMG20A axis, and circABCB10 may be a potential therapeutic target for HCC." 2 The novel circular RNA circ-CAMK2A enhances lung adenocarcinoma metastasis by regulating the miR-615-5p/fibronectin 1 pathway. - hsa_circ_CAMK2A circ-CAMK2A DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "Circ-CAMK2A plays a crucial role in the metastasis of LUAD, at least partially, by regulating the miR-615-5p/fibronectin 1 axis." 1 Circ_0001667 promotes breast cancer cell proliferation and survival via Hippo signal pathway by regulating TAZ. hsa_circ_0001667 hsa_circ_HEATR2 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "This study uncovered that circ_0001667 was a potential breast cancer prognostic marker, as well as a potential therapeutic target to inhibit breast cancer metastasis by circ_0001667/miR-125a-5p/TAZ axis." 4 Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let_7a_5p/IGF2BP3 in cardiomyocytes. - - circRNA_101237 DOID:114 heart disease cardiomyocytes injury "RT-qPCR, microarray" up-regulated "The results identified a novel circRNA_101237/let-7a-5p/IGF2BP3 axis, which regulated cardiomyocyte apoptosis via autophagy regulation, as a potential therapeutic target for the management of cardiovascular diseases." 1 MetaDE-Based Analysis of circRNA Expression Profiles Involved in Gastric Cancer. hsa_circ_0005927 hsa_circ_VDAC3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "Hsa_circ_0005927 and hsa_circ_0067934 were verified in GC tissues, and a GC risk-related network was constructed." 2 MetaDE-Based Analysis of circRNA Expression Profiles Involved in Gastric Cancer. hsa_circ_0067934 hsa_circ_PRKCI - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Hsa_circ_0005927 and hsa_circ_0067934 were verified in GC tissues, and a GC risk-related network was constructed." 3 Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO. - hsa_circ_SMO742 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated CircSMO742 promoted glioma growth by sponging miR-338-3p to regulate SMO expression. 1 Circular RNA circSLC26A4 Accelerates Cervical Cancer Progression via miR-1287-5p/HOXA7 Axis. - hsa_circ_SLC26A4 - DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" up-regulated "These findings demonstrate that circSLC26A4 facilitates cervical cancer progression through the QKI/circSLC26A4/miR-1287-5p/HOXA7 axis, which might bring novel therapeutic strategies for cervical cancer." 1 Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway. - hsa_circ_LARP4 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR down-regulated CircLARP4 sponges miR-1323 and hampers tumorigenesis of ESCC through modulating PTEN/PI3K/AKT pathway. 1 A novel circular RNA circFN1 enhances cisplatin resistance in gastric cancer via sponging miR-182-5p. - hsa_circ_FN1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated A novel circular RNA circFN1 enhances cisplatin resistance in gastric cancer via sponging miR-182-5p. 2 "Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFbetaR2/phosph-SMAD3 axis." hsa_circ_0003204 hsa_circ_USP36 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFbetaR2/phosph-SMAD3 axis." 7 Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer. hsa_circ_0005963 hsa_circ_TMEM128 ciRS-122 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer. 1 Extracellular vesicle-derived circ_SLC19A1 promotes prostate cancer cell growth and invasion through the miR-497/septin 2 pathway. - hsa_circ_SLC19A1 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated Extracellular vesicle-derived circ_SLC19A1 promotes prostate cancer cell growth and invasion through the miR-497/septin 2 pathway. 2 Circular RNA circ-EGLN3 promotes renal cell carcinoma proliferation and aggressiveness via miR-1299-mediated IRF7 activation. - hsa_circ_EGLN3 - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated Circular RNA circ-EGLN3 promotes renal cell carcinoma proliferation and aggressiveness via miR-1299-mediated IRF7 activation. 2 Expression profile and bioinformatics analyses of circular RNAs in keloid and normal dermal fibroblasts. hsa_circ_0008259 hsa_circ_LMO7 - DOID:10881 "hand, foot and mouth disease" keloid microarray down-regulated "Two candidate circRNAs (hsa_circRNA_0008259, hsa_circRNA_0005480) were verified to be significantly reduced in KDFs, and one candidate circRNA (hsa_circRNA_0002198) was significantly elevated in accordance with RNA-Seq data analysis." 1 Expression profile and bioinformatics analyses of circular RNAs in keloid and normal dermal fibroblasts. hsa_circ_0005480 hsa_circ_DCLK2 - DOID:10881 "hand, foot and mouth disease" keloid microarray down-regulated "Two candidate circRNAs (hsa_circRNA_0008259, hsa_circRNA_0005480) were verified to be significantly reduced in KDFs, and one candidate circRNA (hsa_circRNA_0002199) was significantly elevated in accordance with RNA-Seq data analysis." 1 Expression profile and bioinformatics analyses of circular RNAs in keloid and normal dermal fibroblasts. hsa_circ_0002198 hsa_circ_PDE7B - DOID:10881 "hand, foot and mouth disease" keloid microarray up-regulated "Two candidate circRNAs (hsa_circRNA_0008259, hsa_circRNA_0005480) were verified to be significantly reduced in KDFs, and one candidate circRNA (hsa_circRNA_0002200) was significantly elevated in accordance with RNA-Seq data analysis." 1 CircNF1-419 improves the gut microbiome structure and function in AD-like mice. - mmu_circ_NF1-419 - DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated CircNF1-419 improves the gut microbiome structure and function in AD-like mice. 1 Circ-EPB41L5 regulates the host gene EPB41L5 via sponging miR-19a to repress glioblastoma tumorigenesis. - hsa_circ_EPB41L5 circ-EPB41L5 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" down-regulated "The effects of expression of the ectopic intervention of circ-EPB41L5 or EPB41L5 on proliferation, clone formation, migration, and invasion in vitro and tumorigenesis in vivo were observed to evaluate the function of circ-EPB41L5 or EPB41L5." 1 Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression. - - circ_001621 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression. 1 Circ-SOX4 drives the tumorigenesis and development of lung adenocarcinoma via sponging miR-1270 and modulating PLAGL2 to activate WNT signaling pathway. - hsa_circ_SOX4 circ-SOX4 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "Circ-SOX4 boosted the development of LUAD and activate WNT signaling pathway through sponging miR-1270 and modulating PLAGL2, which provided a valuable theoretical basis for exploring underlying therapeutic target in LUAD." 1 Up-regulation of circ_LARP4 suppresses cell proliferation and migration in ovarian cancer by regulating miR-513b-5p/LARP4 axis. - hsa_circ_LARP4 circ_LARP4 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated Circ_LARP4 could hamper cell proliferation and migration by sponging miR-513b-5p to regulate the expression of LARP4. This research may provide some referential value to OC treatment. 2 Circ_0014130 Participates in the Proliferation and Apoptosis of Nonsmall Cell Lung Cancer Cells via the miR-142-5p/IGF-1 Axis. hsa_circ_0014130 - circ_0014130 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Our results indicated that the silencing circ_0014130 inhibited NSCLC cell proliferation and promoted cell apoptosis by upregulating miR-142-5p and downregulating IGF-1 expression. This might provide new strategies for future diagnosis and treatment of NSCLC. 3 CircRNA CDR1as knockdown inhibits progression of non-small-cell lung cancer by regulating miR-219a-5p/SOX5 axis. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Knockdown of circCDR1as inhibited the progression of NSCLC by decreasing cell viability, migration and invasion and increasing apoptosis by upregulating miR-219a-5p and downregulating SOX5." 5 A novel circular RNA (hsa_circ_0000370) increases cell viability and inhibits apoptosis of FLT3-ITD-positive acute myeloid leukemia cells by regulating miR-1299 and S100A7A. hsa_circ_0000370 hsa_circ_FLI1 - DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated We suggest that the promoting effects of circ_0000370 on the progression of FLT3-ITD+ AML might be relevant to the inhibition of miR-1299 and the upregulation of S100A7A. 1 Identification of circRNA-miRNA networks for exploring an underlying prognosis strategy for breast cancer. hsa_circ_0088088 hsa_circ_HSDL2 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated "The high expression of hsa-circRNA-0088088 (p < 0.001), the low expression of hsa-circRNA-00005795 (p < 0.001) and no significant difference in the expression of hsa-circRNA-00000751 were found in exosomes from BT549 cells or MDA-MB-231 cells compared with exosomes from MCF-7 cells." 2 Identification of circRNA-miRNA networks for exploring an underlying prognosis strategy for breast cancer. hsa_circ_0005795 hsa_circ_LPXN - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "The high expression of hsa-circRNA-0088088 (p < 0.001), the low expression of hsa-circRNA-00005795 (p < 0.001) and no significant difference in the expression of hsa-circRNA-00000751 were found in exosomes from BT549 cells or MDA-MB-231 cells compared with exosomes from MCF-7 cells." 1 Circular RNA circVAPA regulates breast cancer cell migration and invasion via sponging miR-130a-5p. - hsa_circ_VAPA - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated CircVAPA may promote migration and invasion capacity of breast cancer via harboring miR-130a-5p. 1 Circular RNA cSMARCA5 regulates the progression of cervical cancer by acting as a microRNA_432 sponge. - hsa_circ_SMARCA5 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated the present findings suggested that cSMARCA5 may play an important role in the progression of cervical cancer via the ERK signaling pathway by modulating miR_432. 3 Extracellular nanovesicles-transmitted circular RNA has_circ_0000190 suppresses osteosarcoma progression. hsa_circ_0000190 hsa_circ_CNIH4 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated Extracellular nanovesicles-transmitted circular RNA has_circ_0000190 suppresses osteosarcoma progression. 1 Circ_0009910 promotes imatinib resistance through ULK1-induced autophagy by sponging miR-34a-5p in chronic myeloid leukemia. hsa_circ_0009910 - Circ_0009910 DOID:8552 chronic myeloid leukemia chronic myeloid leukemia RT-qPCR up-regulated Circ_0009910 promotes imatinib resistance through ULK1-induced autophagy by sponging miR-34a-5p in chronic myeloid leukemia. 1 Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth. - hsa_circ_RHOBTB3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated "Taken together, this study revealed that circRHOBTB3 might function as competing endogenous RNA (ceRNA) for miR-654-3p, which could contribute to growth inhibition of GC through activating p21 signaling pathway. Our data suggested that circRHOBTB3 would serve as a novel promising diagnosis marker and therapeutic target for GC." 2 Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis. - hsa_circ_ABCB10 circ-ABCB10 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ-ABCB10 knockdown enhances sensitivity of lung cancer cells to cisplatin by targeting miR-556-3p/AK4 axis. 4 Hsa_circ_0086414 Might Be a Diagnostic Biomarker of Oral Squamous Cell Carcinoma. hsa_circ_0086414 hsa_circ_BNC2 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "hsa_circ_0086414 might be an essential diagnostic biomarker in OSCC. Furthermore, hsa_circ_0086414 could be a target for OSCC therapy." 2 Hsa_circ_0057481 promotes laryngeal cancer proliferation and migration by modulating the miR-200c/ZEB1 axis. hsa_circ_0057481 hsa_circ_PMS1 - DOID:2600 laryngeal carcinoma laryngeal cancer "RT-qPCR, microarray" up-regulated Our findings showed that hsa_circ_0057481 might act as a novel therapeutic target in laryngeal cancer. 1 "Circular RNA DLGAP4 is down-regulated and negatively correlates with severity, inflammatory cytokine expression and pro-inflammatory gene miR-143 expression in acute ischemic stroke patients." hsa_circ_0060181 hsa_circ_DLGAP4 - DOID:6713 cerebrovascular disease stroke RT-qPCR up-regulated Circulating circ-DLGAP4 could serve as a novel biomarker for diagnosis and disease surveillance of AIS and is negatively correlated with inflammation and miR-143 expression in AIS patients. 1 Detection of serum long non-coding RNA UCA1 and circular RNAs for the diagnosis of bladder cancer and prediction of recurrence. - hsa_circ_FARSA - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "The present study demonstrated that the expression levels of circFARSA, circSHKBP1, and circBANP were significantly higher in the serum of the recurrent group than in that of the non-recurrent group." 2 Detection of serum long non-coding RNA UCA1 and circular RNAs for the diagnosis of bladder cancer and prediction of recurrence. - hsa_circ_SHKBP1 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "The present study demonstrated that the expression levels of circFARSA, circSHKBP1, and circBANP were significantly higher in the serum of the recurrent group than in that of the non-recurrent group." 1 Detection of serum long non-coding RNA UCA1 and circular RNAs for the diagnosis of bladder cancer and prediction of recurrence. - hsa_circ_BANP - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "The present study demonstrated that the expression levels of circFARSA, circSHKBP1, and circBANP were significantly higher in the serum of the recurrent group than in that of the non-recurrent group." 1 Overexpression of circRNA-001175 promotes proliferation and angiogenesis and inhibits apoptosis of the human umbilical vein endothelial cells (HUVECs) induced by high glucose. - - circRNA-001175 DOID:178 vascular disease vascular disease RT-qPCR up-regulated CircRNA-001175 may play a key role of protection on HUVECs from high glucose stress. CircRNA-001175 has great potential to become diagnostic or predictive biomarkers for high glucose disease and provide new insights into the treatment of diseases. 1 Circulating circular RNAs hsa_circ_0001204 and hsa_circ_0001747 act as diagnostic biomarkers for active tuberculosis detection. hsa_circ_0001204 hsa_circ_DGCR8 - DOID:399 tuberculosis tuberculosis RT-qPCR down-regulated Our present study indicates that circulating hsa_circ_0001204 and hsa_circ_0001747 may represent novel plasma biomarkers for TB diagnosis. 3 Circulating circular RNAs hsa_circ_0001204 and hsa_circ_0001747 act as diagnostic biomarkers for active tuberculosis detection. hsa_circ_0001747 hsa_circ_MKLN1 - DOID:399 tuberculosis tuberculosis RT-qPCR down-regulated Our present study indicates that circulating hsa_circ_0001204 and hsa_circ_0001747 may represent novel plasma biomarkers for TB diagnosis. 1 Hsa_circ_0007534 as a blood-based marker for the diagnosis of colorectal cancer and its prognostic value. hsa_circ_0007534 hsa_circ_DDX42 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated All of the results suggest that hsa_circ_0007534 may be a potential cancer marker of patients with CRC and may associate with poor prognosis. 3 CircRNA_100395 inhibits cell proliferation and metastasis in ovarian cancer via regulating miR-1228/p53/epithelial-mesenchymal transition (EMT) axis. - - circ_100395 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated CircRNA_100395 inhibits cell proliferation and metastasis in ovarian cancer via regulating miR-1228/p53/epithelial-mesenchymal transition (EMT) axis. 1 Profiling and integrated analysis of differentially expressed circRNAs as novel biomarkers for breast cancer. hsa_circ_0069094 hsa_circ_S100P - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "The study have validated and analyzed four most upregulated BC-related circRNAs-hsa_circ_0069094, hsa_circ_0062558, hsa_circ_0074026, and hsa_circ_0079876, and four downregulated circRNAs-hsa_circ_0017536, hsa_circ_0023302, hsa_circ_0017650, and hsa_circ_0017545 in BC." 4 Profiling and integrated analysis of differentially expressed circRNAs as novel biomarkers for breast cancer. hsa_circ_0079876 hsa_circ_ANLN - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "The study have validated and analyzed four most upregulated BC-related circRNAs-hsa_circ_0069094, hsa_circ_0062558, hsa_circ_0074026, and hsa_circ_0079876, and four downregulated circRNAs-hsa_circ_0017536, hsa_circ_0023302, hsa_circ_0017650, and hsa_circ_0017545 in BC." 1 Profiling and integrated analysis of differentially expressed circRNAs as novel biomarkers for breast cancer. hsa_circ_0062558 hsa_circ_MMP11 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "The study have validated and analyzed four most upregulated BC-related circRNAs-hsa_circ_0069094, hsa_circ_0062558, hsa_circ_0074026, and hsa_circ_0079876, and four downregulated circRNAs-hsa_circ_0017536, hsa_circ_0023302, hsa_circ_0017650, and hsa_circ_0017545 in BC." 4 Profiling and integrated analysis of differentially expressed circRNAs as novel biomarkers for breast cancer. hsa_circ_0074026 hsa_circ_PITX1 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "The study have validated and analyzed four most upregulated BC-related circRNAs-hsa_circ_0069094, hsa_circ_0062558, hsa_circ_0074026, and hsa_circ_0079876, and four downregulated circRNAs-hsa_circ_0017536, hsa_circ_0023302, hsa_circ_0017650, and hsa_circ_0017545 in BC." 1 Profiling and integrated analysis of differentially expressed circRNAs as novel biomarkers for breast cancer. hsa_circ_0017536 hsa_circ_AKR1C1 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated "The results showed that hsa_circ_0017536, hsa_circ_0023302, hsa_circ_0017650, and hsa_circ_0017545 were all significantly decreased in BC tissues than in paracancerous normal tissues, which is consistent with the microarray data." 1 Profiling and integrated analysis of differentially expressed circRNAs as novel biomarkers for breast cancer. hsa_circ_0023302 hsa_circ_MYEOV - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated "The results showed that hsa_circ_0017536, hsa_circ_0023302, hsa_circ_0017650, and hsa_circ_0017545 were all significantly decreased in BC tissues than in paracancerous normal tissues, which is consistent with the microarray data." 1 Profiling and integrated analysis of differentially expressed circRNAs as novel biomarkers for breast cancer. hsa_circ_0017650 hsa_circ_ITIH5 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated "The results showed that hsa_circ_0017536, hsa_circ_0023302, hsa_circ_0017650, and hsa_circ_0017545 were all significantly decreased in BC tissues than in paracancerous normal tissues, which is consistent with the microarray data." 2 Profiling and integrated analysis of differentially expressed circRNAs as novel biomarkers for breast cancer. hsa_circ_0017545 hsa_circ_AKR1C3 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated "The results showed that hsa_circ_0017536, hsa_circ_0023302, hsa_circ_0017650, and hsa_circ_0017545 were all significantly decreased in BC tissues than in paracancerous normal tissues, which is consistent with the microarray data." 1 Profiling and integrated analysis of differentially expressed circRNAs as novel biomarkers for breast cancer. hsa_circ_0017650 hsa_circ_ITIH5 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "Hsa_circ_0069094, hsa_circ_0079876, hsa_circ_0017650, and hsa_circ_0017526 were upregulated in plasma." 2 Profiling and integrated analysis of differentially expressed circRNAs as novel biomarkers for breast cancer. hsa_circ_0017526 hsa_circ_tAKR - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "Hsa_circ_0069094, hsa_circ_0079876, hsa_circ_0017650, and hsa_circ_0017526 were upregulated in plasma." 1 miR-449c-5p availability is antagonized by circ-NOTCH1 for MYC-induced NOTCH1 upregulation as well as tumor metastasis and stemness in gastric cancer. - hsa_circ_NOTCH1 circ-NOTCH1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circ-NOTCH1 promoted metastasis and stemness in GC by targeting miR-449c-5p/MYC/NOTCH1 axis, suggesting the possibility of circ-NOTCH1 as a therapeutic marker for GC." 3 Circular RNA SMARCA5 may serve as a tumor suppressor in non-small cell lung cancer. - hsa_circ_SMARCA5 circ-SMARCA5 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "Circ-SMARCA5 may serve as a tumor suppressor in NSCLC, which provides insight to the exploration of novel strategies in NSCLC management." 2 Exosome-transmitted circ_MMP2 promotes hepatocellular carcinoma metastasis by upregulating MMP2. hsa_circ_0039411 hsa_circ_MMP2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Exosome-transmitted circ_MMP2 promotes hepatocellular carcinoma metastasis by upregulating MMP2. 1 circCELSR1 (hsa_circ_0063809) Contributes to Paclitaxel Resistance of Ovarian Cancer Cells by Regulating FOXR2 Expression via miR-1252. hsa_circ_0063809 hsa_circ_CELSR1 - DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, microarray" up-regulated We explored the specific mechanisms of PTX resistance and tumor progress of ovarian cancer due to circCELSR1; presented the circCELSR1-miR-1252-FOXR2 axis and its role in ovarian cancer drug sensitivity and progression; and suggest that the results may provide an experimental basis for clinical application. 3 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0005273 hsa_circ_PTK2 - DOID:9538 multiple myeloma multiple myeloma microarray up-regulated "In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls." 1 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0077765 hsa_circ_RNF217 - DOID:9538 multiple myeloma multiple myeloma microarray up-regulated "In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls." 1 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0009581 hsa_circ_RERE - DOID:9538 multiple myeloma multiple myeloma microarray up-regulated "In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls." 1 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0007146 hsa_circ_NAGPA - DOID:9538 multiple myeloma multiple myeloma microarray up-regulated "In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls." 1 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0004136 hsa_circ_KCNQ5 - DOID:9538 multiple myeloma multiple myeloma microarray up-regulated "In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls." 2 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0001947 hsa_circ_AFF2 - DOID:9538 multiple myeloma multiple myeloma microarray down-regulated "In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls." 1 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0001910 hsa_circ_WWC3 - DOID:9538 multiple myeloma multiple myeloma microarray down-regulated "In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls." 1 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0007609 hsa_circ_DNAJC5 - DOID:9538 multiple myeloma multiple myeloma microarray down-regulated "In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls." 1 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0071375 hsa_circ_KLHL2 - DOID:9538 multiple myeloma multiple myeloma microarray down-regulated "In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls." 1 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0000651 hsa_circ_IQGAP1 - DOID:9538 multiple myeloma multiple myeloma microarray down-regulated "In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls." 1 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0020594 hsa_circ_None - DOID:9538 multiple myeloma multiple myeloma microarray down-regulated "In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls." 1 circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma. - - circRNA-002178 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated circRNA-002178 could act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma. 1 Circ-PAX2 promotes proliferation and metastasis by absorbing miR-186 in lung cancer cells. - hsa_circ_PAX2 circ-PAX2 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Circ-PAX2 promotes proliferation and metastasis by absorbing miR-186 in lung cancer cells. 1 "CircRNA circFNDC3B promotes esophageal cancer progression via cell proliferation, apoptosis, and migration regulation." - hsa_circ_FNDC3B - DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated The circFNDC3B encoded by two FNDC3B gene exons is an important regulator of esophageal cancer progression. 1 Hsa_circ_0102533 serves as a blood-based biomarker for non-small-cell lung cancer diagnosis and regulates apoptosis in vitro. hsa_circ_0102533 hsa_circ_PCNX - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated hsa_circ_0102533 possesses an oncogenic property in the carcinogenesis of NSCLC and might be an early diagnostic biomarker for NSCLC detection. 1 hsa_circ0021347 as a Potential Target Regulated by B7-H3 in Modulating the Malignant Characteristics of Osteosarcoma. hsa_circ_0021347 hsa_circ_SOX6 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated hsa_circ0021347 was selected and validated to be significantly downregulated in OS tissues and cell lines and showed a strong negative relationship with B7-H3 expression in OS. 1 "Circ_LAS1L regulates cardiac fibroblast activation, growth, and migration through miR-125b/SFRP5 pathway." - hsa_circ_LAS1L - DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR down-regulated "This suggests that circ_LAS1L/miR-125b/SFRP5 pathway can regulate the biological function of CF and may play an important role in the process of myocardial fibrosis, thus providing an important theoretical basis for the regulation of myocardial fibrosis after myocardial infarction." 1 circRNA circ-CCND1 promotes the proliferation of laryngeal squamous cell carcinoma through elevating CCND1 expression via interacting with HuR and miR-646. - hsa_circ_CCND1 - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "circ-CCND1 physically bound to human antigen R (HuR) protein to enhance CCND1 mRNA stability; on the other hand, circ-CCND1 could act as an effective sponge for miR-646 to alleviate the repression of miR-646 on CCND1 mRNA. As a result, circ-CCND1 post-transcriptionally elevated CCND1 expression via coordinated avoidance of CCND1 mRNA decay, thereby promoting LSCC tumorigenesis." 2 circCAMSAP1 Promotes Tumor Growth in Colorectal Cancer via the miR-328-5p/E2F1 Axis. hsa_circ_0089477 hsa_circ_CAMSAP1 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "Our data indicated an essential role of the circCAMSAP1/miR-328-5p/E2F1 axis in the progression of CRC, which implied that circCAMSAP1 could serve as a diagnostic and prognostic biomarker as well as a potential therapeutic target for CRC." 2 Circular RNA circFOXM1 Plays a Role in Papillary Thyroid Carcinoma by Sponging miR-1179 and Regulating HMGB1 Expression. hsa_circ_0025033 hsa_circ_FOXM1 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated Our study demonstrated that circFOXM1 modulates cancer progression through the miR-1179/HMGB1 pathway in PTC. Our findings indicate that circFOXM1 may serve as a promising therapeutic target for the treatment of PTC patients. 2 "Circ_0063517 acts as ceRNA, targeting the miR-31-5p-ETBR axis to regulate angiogenesis of vascular endothelial cells in preeclampsia." hsa_circ_0063517 - circ_0063517 DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated Our findings suggest that circ_0063517-miR-31-5p-ETBR axis regulates angiogenesis during the pathological process of PE. 1 Knockdown of circ_0084043 suppresses the development of human melanoma cells through miR-429/tribbles homolog 2 axis and Wnt/beta-catenin pathway. hsa_circ_0084043 - circ_0084043 DOID:1909 melanoma melanoma RT-qPCR up-regulated Knockdown of circ_0084043 suppressed the malignant development of melanoma presumably through modulating miR429/TRIB2 axis and inactivating Wnt/beta-catenin signaling pathway. 3 Circular RNA-ZNF609 regulates corneal neovascularization by acting as a sponge of miR-184. - rno_circ_ZNF609 - DOID:11382 corneal neovascularization corneal neovascularization RT-qPCR up-regulated cZNF609/miR-184 interaction regulated the downstream Akt and VEGF signaling pathway. Intervention of cZNF609 and miR-184 may serve as a potential strategy for pathological corneal neovascularization treatment. 1 "CircZDHHC20 represses the proliferation, migration and invasion in trophoblast cells by miR-144/GRHL2 axis." - hsa_circ_ZDHHC20 - DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated "Our study suggested that a high level of circZDHHC20 inhibited the proliferation, migration, and invasion in trophoblast cells at least partially through sponging miR-144 and up-regulating GRHL2, providing a novel mechanism of PE pathogenesis." 1 Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA-328-3p-mediated inhibition of COL1A1. - - hsa_circRNA_002178 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "Hsa_circRNA_002178 could competitively bind to miR-328-3p and down-regulated its expression. Restoration of miR-328-3p eliminated the tumour-promoting effects of hsa_circRNA_002178. COL1A1, as a target of miR-328-3p, could be up-regulated by overexpression of hsa_circRNA_002178. In vivo experiments further confirmed the inhibition of tumour growth and inflammation by silencing hsa_circRNA_002178 or up-regulating miR-328-3p." 1 "Cyclic RNA hsa_circ_0091017 inhibits proliferation, migration and invasiveness of bladder cancer cells by binding to microRNA-589-5p." hsa_circ_0091017 - hsa_circ_0091017 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "The circular RNA hsa_circ_0091017 can inhibit the proliferation, migration and invasiveness of BCa cells by regulating the expression of microRNA-589-5p." 2 "Circular RNA hsa_circ_0006168 contributes to cell proliferation, migration and invasion in esophageal cancer by regulating miR-384/RBBP7 axis via activation of S6K/S6 pathway." hsa_circ_0006168 - hsa_circ_0006168 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "Abundance of circ_0006168 contributes to cell proliferation, migration, invasion, and glycolysis in EC by competitively sponging miR-384 to facilitate RBBP7 expression, representing prospective targets for EC therapy." 1 CircRNA 010567 improves myocardial infarction rats through inhibiting TGF-beta1. - - circRNA 010567 DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated "CircRNA 010567 siRNA can improve the cardiac function, alleviate the MF, and inhibit the myocardial apoptosis, thereby further suppressing MI-induced MF, whose mechanism may be related to the inhibition on the TGF-beta1 signaling pathway." 1 Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p. - hsa_circ_RSF1 - DOID:409 liver disease radiation-induced liver disease RT-qPCR up-regulated "Enforced expression of circRSF1 increased RAC1 expression by acting as miR-146a-5p sponge to inhibit miR-146a-5p activity, and thus enhanced the cell viability, and promoted inflammatory and fibrotic phenotype of irradiated LX2 cells. " 1 Circular RNA hsa_circ_0004277 contributes to malignant phenotype of colorectal cancer by sponging miR-512-5p to upregulate the expression of PTMA. hsa_circ_0004277 hsa_circ_WDR37 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated our study showed that circ-0004277 promoted the proliferation of colorectal cancer cells as a miR-512-5p sponge to upregulate the PTMA expression. 1 Circular RNA cir-ITCH Promotes Osteosarcoma Migration and Invasion through cir-ITCH/miR-7/EGFR Pathway. - hsa_circ_ITCH cir-ITCH DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated our research uncovered an important role of the cir-ITCH/miR-7/EGFR pathway in the migration and invasion of osteosarcoma cells and suggested that cir-ITCH may be a prognostic marker and a promising therapeutic target for osteosarcoma. 2 CircTIMELESS regulates the proliferation and invasion of lung squamous cell carcinoma cells via the miR-136-5p/ROCK1 axis. hsa_circ_0000408 hsa_circ_TIMELESS - DOID:3907 lung squamous cell carcinoma lung squamous cell carcinoma "RT-qPCR, microarray" up-regulated CircTIMELESS regulates the proliferation and invasion of lung squamous cell carcinoma cells via the miR-136-5p/ROCK1 axis. 1 Circular RNA circABCC4 regulates lung adenocarcinoma progression via miR-3186-3p/TNRC6B axis. - hsa_circ_ABCC4 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Circular RNA circABCC4 regulates lung adenocarcinoma progression via miR-3186-3p/TNRC6B axis. 1 Insights into the expression profiles and functions of circRNAs in a newborn hyperoxia-induced rat bronchopulmonary dysplasia model. - - chr15:67588477-67588841 DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, RNA-seq" down-regulated "Chr15:67588477|67588841, chr19:9683854|9684128, chr1:87010380|87010777 and chr8:71336875|71337745 were down-regulated in the hyperoxia group compared to the normoxia group, which is consistent with the RNA-seq data. However, both chr18:49891333|49891588 and chr1:142682098|142682602 are predicted to be up-regulated in the RNA-seq, although the RT-PCR results indicate that these two genes are down-regulated." 1 Insights into the expression profiles and functions of circRNAs in a newborn hyperoxia-induced rat bronchopulmonary dysplasia model. - - chr19:9683854-9684128 DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, RNA-seq" down-regulated "Chr15:67588477|67588841, chr19:9683854|9684128, chr1:87010380|87010777 and chr8:71336875|71337745 were down-regulated in the hyperoxia group compared to the normoxia group, which is consistent with the RNA-seq data. However, both chr18:49891333|49891588 and chr1:142682098|142682602 are predicted to be up-regulated in the RNA-seq, although the RT-PCR results indicate that these two genes are down-regulated." 1 Insights into the expression profiles and functions of circRNAs in a newborn hyperoxia-induced rat bronchopulmonary dysplasia model. - - chr1:87010380-87010777 DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, RNA-seq" down-regulated "Chr15:67588477|67588841, chr19:9683854|9684128, chr1:87010380|87010777 and chr8:71336875|71337745 were down-regulated in the hyperoxia group compared to the normoxia group, which is consistent with the RNA-seq data. However, both chr18:49891333|49891588 and chr1:142682098|142682602 are predicted to be up-regulated in the RNA-seq, although the RT-PCR results indicate that these two genes are down-regulated." 1 Insights into the expression profiles and functions of circRNAs in a newborn hyperoxia-induced rat bronchopulmonary dysplasia model. - - chr8:71336875-71337745 DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, RNA-seq" down-regulated "Chr15:67588477|67588841, chr19:9683854|9684128, chr1:87010380|87010777 and chr8:71336875|71337745 were down-regulated in the hyperoxia group compared to the normoxia group, which is consistent with the RNA-seq data. However, both chr18:49891333|49891588 and chr1:142682098|142682602 are predicted to be up-regulated in the RNA-seq, although the RT-PCR results indicate that these two genes are down-regulated." 1 Insights into the expression profiles and functions of circRNAs in a newborn hyperoxia-induced rat bronchopulmonary dysplasia model. - - chr18:49891333-49891588 DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, RNA-seq" down-regulated "Chr15:67588477|67588841, chr19:9683854|9684128, chr1:87010380|87010777 and chr8:71336875|71337745 were down-regulated in the hyperoxia group compared to the normoxia group, which is consistent with the RNA-seq data. However, both chr18:49891333|49891588 and chr1:142682098|142682602 are predicted to be up-regulated in the RNA-seq, although the RT-PCR results indicate that these two genes are down-regulated." 1 Insights into the expression profiles and functions of circRNAs in a newborn hyperoxia-induced rat bronchopulmonary dysplasia model. - - chr1:142682098-142682602 DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, RNA-seq" down-regulated "Chr15:67588477|67588841, chr19:9683854|9684128, chr1:87010380|87010777 and chr8:71336875|71337745 were down-regulated in the hyperoxia group compared to the normoxia group, which is consistent with the RNA-seq data. However, both chr18:49891333|49891588 and chr1:142682098|142682602 are predicted to be up-regulated in the RNA-seq, although the RT-PCR results indicate that these two genes are down-regulated." 1 Circular RNA hsa_circ_0061825 (circ-TFF1) contributes to breast cancer progression through targeting miR-326/TFF1 signalling. hsa_circ_0061825 hsa_circ_TFF1 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq, microarray" up-regulated "Circ-TFF1 is a facilitator in breast cancer relying on TFF1 by absorbing miR-326, providing a novel promising target for BC treatment." 3 hsa_circ_0062389 promotes the progression of non-small cell lung cancer by sponging miR-103a-3p to mediate CCNE1 expression. hsa_circ_0062389 hsa_circ_PI4KA - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our results showed that the hsa_circ_0062389/miR-103a-3p/CCNE1 axis might contribute to the tumorigenesis of NSCLC, which provided a new strategy for cancer treatment." 1 Circular RNA 0007255 regulates the progression of breast cancer through miR-335-5p/SIX2 axis. hsa_circ_0007255 hsa_circ_KIF4A - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_0007255 functioned as a novel oncogene in the progression of BC by regulating miR-335-5p/SIX2 axis, and might be a promising biomarker for BC treatment." 4 Circular RNA FAM114A2 suppresses progression of bladder cancer via regulating _NP63 by sponging miR-762. - hsa_circ_FAM114A2 - DOID:4006 bladder urothelial carcinoma bladder urothelial carcinoma RT-qPCR down-regulated "circFAM114A2 might serve as a competing endogenous RNA (ceRNA) of miR-762 in regulating the expression of _NP63, thus suppressed UCB progression through circFAM114A2/miR-762/_NP63 axis." 2 "Circular RNA VRK1 correlates with favourable prognosis, inhibits cell proliferation but promotes apoptosis in breast cancer." hsa_circ_0141206 hsa_circ_VRK1 - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "Circ-VRK1 is downregulated in tumour tissues and associated with reduced tumour stage as well as better survival, and it inhibits cell proliferation but promotes cell apoptosis in breast cancer." 2 CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer. hsa_circ_0005273 hsa_circ_PTK2 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "circPTK2 exerts critical roles in CRC growth and metastasis and may serve as a potential therapeutic target for CRC metastasis, and also a promising biomarker for early diagnosis of metastasis." 4 Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis. - - circRNA-100338 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis. 2 The circular RNA hsa_circ_0007623 acts as a sponge of microRNA-297 and promotes cardiac repair. hsa_circ_0007623 hsa_circ_ZNF432 - DOID:1287 cardiovascular system disease myocardial ischemia RT-qPCR up-regulated "functional experiments revealed hsa_circ_0007623 silencing could up-regulate miR-297 and down-regulate VEGFA expression, and reduce cell proliferation, migration, and angiogenesis. We concluded that hsa_circ_0007623 can bind to miR-297, promote cardiac repair after acute myocardial ischemia, and protect cardiac function." 1 CircRNA expression profiles in human visceral preadipocytes and adipocytes. hsa_circ_0136134 hsa_circ_LPL - DOID:9970 obesity obesity "RT-qPCR, microarray" up-regulated This is the first study of the expression profiles of circRNAs in HPA-v and adipocytes and may suggest potential therapeutic targets for the visceral obesity. 1 CircRNA expression profiles in human visceral preadipocytes and adipocytes. hsa_circ_0017650 hsa_circ_ITIH5 - DOID:9970 obesity obesity "RT-qPCR, microarray" up-regulated This is the first study of the expression profiles of circRNAs in HPA-v and adipocytes and may suggest potential therapeutic targets for the visceral obesity. 1 CircRNA expression profiles in human visceral preadipocytes and adipocytes. - - hsa-circRNA9227-1 DOID:9970 obesity obesity "RT-qPCR, microarray" up-regulated This is the first study of the expression profiles of circRNAs in HPA-v and adipocytes and may suggest potential therapeutic targets for the visceral obesity. 1 ciRS-7 targeting miR-135a-5p promotes neuropathic pain in CCI rats via inflammation and autophagy. - - ciRS-7 DOID:936 brain disease neuropathic pain RT-qPCR up-regulated "we found ciRS-7 regulates neuropathic pain progress by sponging to miR-135a-5p. In CCI rats, inhibiting miR-135a-5p decreases the level of autophagy and inflammation and alleviates neuropathic pain. We present this research that might provide a new insight for neuropathic pain study." 1 CircRNA_0000502 promotes hepatocellular carcinoma metastasis and inhibits apoptosis through targeting microRNA-124. hsa_circ_0000502 - circRNA_0000502 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "High expression of circ_0000502 was significantly positively correlated with poor prognosis of HCC. Besides, circ_0000502 promoted the malignant progression of HCC by regulating miR-124 expression." 2 CircCTDP1 promotes nasopharyngeal carcinoma progression via a microRNA_320b/HOXA10/TGFbeta2 pathway. - hsa_circ_CTDP1 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated CircCTDP1 promotes nasopharyngeal carcinoma progression via a microRNA_320b/HOXA10/TGFbeta2 pathway. 1 CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis. - hsa_circ_PVT1 - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis. 3 Circular RNA Expression Profiles in Plasma from Patients with Heart Failure Related to Platelet Activity. hsa_circ_0062960 hsa_circ_DEPDC5 - DOID:114 heart disease heart failure microarray up-regulated "Among the dysregulated circRNAs, hsa_circ_0112085 (p = 0.0032), hsa_circ_0062960 (p = 0.0006), hsa_circ_0053919 (p = 0.0074) and hsa_circ_0014010 (p = 0.025) showed significantly higher expression in patients with HF compared with healthy controls. " 1 Circular RNA Expression Profiles in Plasma from Patients with Heart Failure Related to Platelet Activity. hsa_circ_0112085 hsa_circ_MARC2 - DOID:114 heart disease heart failure microarray up-regulated "Among the dysregulated circRNAs, hsa_circ_0112085 (p = 0.0032), hsa_circ_0062960 (p = 0.0006), hsa_circ_0053919 (p = 0.0074) and hsa_circ_0014010 (p = 0.026) showed significantly higher expression in patients with HF compared with healthy controls." 1 Circular RNA Expression Profiles in Plasma from Patients with Heart Failure Related to Platelet Activity. hsa_circ_0053919 hsa_circ_LTBP1 - DOID:114 heart disease heart failure microarray up-regulated "Among the dysregulated circRNAs, hsa_circ_0112085 (p = 0.0032), hsa_circ_0062960 (p = 0.0006), hsa_circ_0053919 (p = 0.0074) and hsa_circ_0014010 (p = 0.027) showed significantly higher expression in patients with HF compared with healthy controls." 2 Circular RNA Expression Profiles in Plasma from Patients with Heart Failure Related to Platelet Activity. hsa_circ_0014010 hsa_circ_PRPF3 - DOID:114 heart disease heart failure microarray up-regulated "Among the dysregulated circRNAs, hsa_circ_0112085 (p = 0.0032), hsa_circ_0062960 (p = 0.0006), hsa_circ_0053919 (p = 0.0074) and hsa_circ_0014010 (p = 0.028) showed significantly higher expression in patients with HF compared with healthy controls." 1 Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas. - hsa_circ_MAPK4 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circ-MAPK4 is a critical player in glioma cell survival and apoptosis via p38/MAPK signaling pathway through modulation of miR-125a-3p, which can serve as a new therapeutic target for treatment of gliomas." 2 Circular RNA Circ-ITCH Inhibits the Malignant Behaviors of Cervical Cancer by microRNA-93-5p/FOXK2 Axis. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated circ-ITCH executed its tumor suppressive activity through sponging microRNA-93-5p (miR-93-5p) and regulating the expression of forkhead box K2 (FOXK2). 1 Targeting the estrogen receptor alpha (ERalpha)-mediated circ-SMG1.72/miR-141-3p/Gelsolin signaling to better suppress the HCC cell invasion. - hsa_circ_SMG1.72 circRNA-SMG1.72 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "ERalpha can suppress HCC cell invasion via altering the ERalpha/circRNA-SMG1.72/miR-141-3p/GSN signaling, and targeting this newly identified signaling with small molecules may help in the development of novel therapies to better suppress the HCC progression." 1 Circular RNA CCDC66 facilitates abdominal aortic aneurysm through the overexpression of CCDC66. - hsa_circ_CCDC66 - DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm RNA-seq up-regulated "circCCDC66/miR-342-3p/CCDC66 axis was proved can play the function of modulating the cell proliferation and apoptosis of VSMCs, which provided us a novel molecular mechanism in AAA." 1 Circular RNA ATXN7 promotes the development of gastric cancer through sponging miR-4319 and regulating ENTPD4. - hsa_circ_ATXN7 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circular RNA ATXN7 promotes the development of gastric cancer through sponging miR-4319 and regulating ENTPD4. 1 Protective Effect of Circular RNA (CircRNA) Ddx17 in Ovalbumin (OVA)-Induced Allergic Rhinitis (AR) Mice. - mmu_circ_Ddx17 CircDdx17 DOID:4481 allergic rhinitis Allergic Rhinitis RT-qPCR down-regulated overexpression of circDdx17 inhibited the expression of miR-17-5p and alleviated the condition of AR 1 Microarray analysis of circRNAs expression profile in gliomas reveals that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling. hsa_circ_0037655 - circ_0037655 DOID:0060108 brain glioma glioma "RT-qPCR, microarray" up-regulated Microarray analysis of circRNAs expression profile in gliomas reveals that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling. 2 Analysis of circular RNA-associated competing endogenous RNA network in breast cancer. hsa_circ_0000520 hsa_circ_RPPH1 - DOID:1612 breast cancer breast cancer microarray up-regulated the analyses of the raw microarray data conducted in the present study offer perspectives on the exploration of mechanisms associated with BC tumorigenesis with regard to the circRNA-miRNA-mRNA network. 9 Analysis of circular RNA-associated competing endogenous RNA network in breast cancer. hsa_circ_0006220 hsa_circ_TADA2A - DOID:1612 breast cancer breast cancer microarray down-regulated the analyses of the raw microarray data conducted in the present study offer perspectives on the exploration of mechanisms associated with BC tumorigenesis with regard to the circRNA-miRNA-mRNA network. 4 Analysis of circular RNA-associated competing endogenous RNA network in breast cancer. hsa_circ_0000977 hsa_circ_NOL10 - DOID:1612 breast cancer breast cancer microarray down-regulated the analyses of the raw microarray data conducted in the present study offer perspectives on the exploration of mechanisms associated with BC tumorigenesis with regard to the circRNA-miRNA-mRNA network. 4 Analysis of circular RNA-associated competing endogenous RNA network in breast cancer. hsa_circ_0043278 hsa_circ_TADA2A - DOID:1612 breast cancer breast cancer microarray down-regulated the analyses of the raw microarray data conducted in the present study offer perspectives on the exploration of mechanisms associated with BC tumorigenesis with regard to the circRNA-miRNA-mRNA network. 4 CircBACH1 (hsa_circ_0061395) promotes hepatocellular carcinoma growth by regulating p27 repression via HuR. hsa_circ_0061395 hsa_circ_BACH1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated CircBACH1 (hsa_circ_0061395) promotes hepatocellular carcinoma growth by regulating p27 repression via HuR. 4 Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3. hsa_circ_0070963 hsa_circ_SCLT1 - DOID:409 liver disease liver fibrosis "RT-qPCR, microarray" down-regulated hsa_circ_0070963 appeared to function as a miR-223-3p sponge that inhibited HSC activation in liver fibrosis via regulation of miR-223-3p and LEMD3. 2 Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemoresistance by regulating BMI1 through miR-340. - - Hsa_circ_001680 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemoresistance by regulating BMI1 through miR-340. 1 Utility Of Plasma circBNC2 As A Diagnostic Biomarker In Epithelial Ovarian Cancer. - hsa_circ_BNC2 - DOID:2152 ovary epithelial cancer epithelial ovarian cancer RT-qPCR up-regulated CircBNC2 is downregulated in EOC and warrants investigation in a screening study in females at risk for EOC. 1 Differential expression profile study and gene function analysis of maternal foetal-derived circRNA for screening for Down syndrome. - - hsa_circRNA_103112 DOID:14250 Down syndrome downs syndrome microarray up-regulated "Therefore, the level of hsa_circRNA_103112 in the peripheral blood of a pregnant woman may serve as potential biomarker of fetal DS during non-invasive prenatal screening." 1 Circ-ZKSCAN1 regulates FAM83A expression and inactivates MAPK signaling by targeting miR-330-5p to promote non-small cell lung cancer progression. - hsa_circ_ZKSCAN1 circ-ZKSCAN1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ-ZKSCAN1 is a key positive regulator of NSCLC, and clarifies the potential molecular mechanism of the new circ-ZKSCAN1/miR-330-5p/FAM83A feedback loop in promoting the progress of NSCLC." 1 Prognostic model based on circular RNA circPDK1 for resected lung squamous cell carcinoma. - hsa_circ_PDK1 - DOID:1324 lung cancer lung cancer RNA-seq up-regulated "circPDK1 was identified as a potential biomarker of resected LSCC. The prognostic model including circPDK1, T staging, LN status, age, and SCCAg could effectively predict prognosis of resected LSCC." 1 Knockdown of circular RNA UBAP2 inhibits the malignant behaviours of esophageal squamous cell carcinoma by microRNA-422a/Rab10 axis. - hsa_circ_UBAP2 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "circUBAP2 exerted its role via sponging microRNA (miR)-422a, and miR-422a directly targeted Rab10 in ESCC cells. These findings suggested that circUBAP2 acted as oncogene through regulating the miR-422a/Rab10 axis in ESCC." 1 Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression. hsa_circ_0051443 hsa_circ_TRAPPC6A - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression. 1 Overexpression of circRNA_100290 promotes the progression of laryngeal squamous cell carcinoma through the miR-136-5p/RAP2C axis. - - circRNA_100290 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "circRNA_100290 promotes LSCC progression by targeting the miR-136-5p/RAP2C axis, which may lead to the identification of potential therapeutic targets." 1 Identification of a potentially functional circRNA-miRNA-mRNA regulatory network for investigating pathogenesis and providing possible biomarkers of bladder cancer. hsa_circ_0011385 hsa_circ_EIF3I - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "Hsa_circ_0011385 showed upregulated tendency in BCa tissues corroborated by qRT-PCR, hsa_circ_0011385 may function as a ceRNA, which plays a critical role in carcinogenesis-related pathways, providing new avenues for mechanistic investigation and offering a potential biomarker for BCa." 1 Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666. - hsa_circ_PVT1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666. 3 Circular Noncoding RNA NR3C1 Acts as a miR-382-5p Sponge to Protect RPE Functions via Regulating PTEN/AKT/mTOR Signaling Pathway. - hsa_circ_NR3C1 - DOID:10871 age related macular degeneration age-related macular degeneration "RT-qPCR, RNA-seq" down-regulated circNR3C1 prevents AMD progression and protects RPE by directly sponging miR-382-5p to block its interaction with PTEN and subsequently blocks the AKT/mTOR pathway. Pharmacological circNR3C1 supplementations are promising therapeutic options for atrophic AMD. 1 circRIP2 accelerates bladder cancer progression via miR-1305/Tgf-beta2/smad3 pathway. - hsa_circ_RIP2 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated circRIP2 accelerates bladder cancer progression via miR-1305/Tgf-beta2/smad3 pathway. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. mmu_circ_0005545 mmu_circ_Cdh9 - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR down-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Trpc6 - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR down-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Cep112 - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR down-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Ncoa2 - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR down-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Wdr49 - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR up-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Myrip - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR up-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Cacna1a - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR down-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Cacna1c - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR down-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Hivep2 - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR up-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Zcchc11 - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR down-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Rmst - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR up-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Cdc14b - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR down-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Tshz2 - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR up-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder. - mmu_circ_Ryr3 - DOID:0060041 autism spectrum disorder autism spectrum disorder RT-qPCR down-regulated Thirteen circRNAs and their corresponding linear isoforms were validated by RT-qPCR analysis. 1 Circular RNA circMAN2B2 promotes growth and migration of gastric cancer cells by down-regulation of miR-145. - hsa_circ_MAN2B2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated This work presented the oncogenic function of circMAN2B2 in GC cells growth and migration. CircMAN2B2 exerted its function possibly through regulating miR-145 as well as PI3K/AKT and JNK pathways. 1 Circular RNA circHIAT1 inhibits proliferation and epithelial-mesenchymal transition of gastric cancer cell lines through downregulation of miR-21. - hsa_circ_HIAT1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "circHIAT1 inhibited the activation of phosphatase and tensin homolog/phosphatidylinositol 3 kinase/protein kinase B and extracellular signal-regulated kinase signal pathways via downregulating miR-21. CircHIAT1 functioned as a tumor inhibitor in GC cells through downregulating miR-21, and could be a novel target for GC treatment." 3 CircPRMT5 circular RNA promotes proliferation of colorectal cancer through sponging miR-377 to induce E2F3 expression. - hsa_circ_PRTM5 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated CircPRMT5 circular RNA promotes proliferation of colorectal cancer through sponging miR-377 to induce E2F3 expression. 1 "Circular RNA circHUWE1 Is Upregulated and Promotes Cell Proliferation, Migration and Invasion in Colorectal Cancer by Sponging miR-486." - hsa_circ_HUWE1 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "Circular RNA circHUWE1 Is Upregulated and Promotes Cell Proliferation, Migration and Invasion in Colorectal Cancer by Sponging miR-486." 1 circGFRA1 Enhances NSCLC Progression by Sponging miR-188-3p. - hsa_circ_GFRA1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our study elaborated a novel circGFRA-miR-188-3p-PI3K/AKT regulatory pathway, providing a potential diagnostic biomarker and therapeutic target for NSCLC." 1 Circular RNA Profiling Reveals That circRNA_104433 Regulates Cell Growth by Targeting miR-497-5p in Gastric Cancer. - - hsa_circRNA_104433 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Knockdown of circRNA_104433 inhibited cell cycle transition, and cell proliferation, while promoted cell apoptosis in GC. CircRNA_104433 directly binds to miR-497-5p, which directly regulates CDC25A." 1 Diagnostic Significance of Downregulated circMORC3 as a Molecular Biomarker of Hypopharyngeal Squamous Cell Carcinoma: A Pilot Study. - hsa_circ_MORC3 - DOID:8533 hypopharynx cancer hypopharyngeal cancer RT-qPCR down-regulated "Our results indicate that circMORC3 was downregulated in HSCC tissues and plasma, and it could serve as an early diagnostic HSCC biomarker." 2 Circular RNA HIPK3 Promotes EMT of Cervical Cancer Through Sponging miR-338-3p to Up-Regulate HIF-1alpha. hsa_circ_0000284 hsa_circ_HIPK3 circ-HIPK3 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Circular RNA HIPK3 Promotes EMT of Cervical Cancer Through Sponging miR-338-3p to Up-Regulate HIF-1alpha. 4 Upregulation of hsa_circ_0007874 suppresses the progression of ovarian cancer by regulating the miR-760/SOCS3 pathway. hsa_circ_0007874 - hsa_circ_0007874 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated Upregulation of hsa_circ_0007874 suppresses the progression of ovarian cancer by regulating the miR-760/SOCS3 pathway. 2 circ-CEP85L suppresses the proliferation and invasion of gastric cancer by regulating NFKBIA expression via miR-942-5p. - hsa_circ_CEP85L circ-CEP85L DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated circ-CEP85L suppresses the proliferation and invasion of gastric cancer by regulating NFKBIA expression via miR-942-5p. 1 Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia. - - hsa_circRNA_402130 DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" down-regulated "The differential expression of hsa_circRNA_402130, hsa_circRNA_072697, hsa_circRNA_030050, hsa_circRNA_100812 and hsa_circRNA_406168 was confirmed by qRT-PCR. Enrichment analysis revealed the association of hsa_circRNA_402130 and hsa_circRNA_072697 with multiple signaling pathways." 1 Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia. - - hsa_circRNA_100812 DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" down-regulated "The differential expression of hsa_circRNA_402130, hsa_circRNA_072697, hsa_circRNA_030050, hsa_circRNA_100812 and hsa_circRNA_406168 was confirmed by qRT-PCR. Enrichment analysis revealed the association of hsa_circRNA_402130 and hsa_circRNA_072698 with multiple signaling pathways." 1 Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia. - - hsa_circRNA_406168 DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" down-regulated "The differential expression of hsa_circRNA_402130, hsa_circRNA_072697, hsa_circRNA_030050, hsa_circRNA_100812 and hsa_circRNA_406168 was confirmed by qRT-PCR. Enrichment analysis revealed the association of hsa_circRNA_402130 and hsa_circRNA_072699 with multiple signaling pathways." 1 Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia. - - hsa_circRNA_072697 DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" up-regulated "The differential expression of hsa_circRNA_402130, hsa_circRNA_072697, hsa_circRNA_030050, hsa_circRNA_100812 and hsa_circRNA_406168 was confirmed by qRT-PCR. Enrichment analysis revealed the association of hsa_circRNA_402130 and hsa_circRNA_072700 with multiple signaling pathways." 1 Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia. - - hsa_circRNA_104078 DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" up-regulated "The differential expression of hsa_circRNA_402130, hsa_circRNA_072697, hsa_circRNA_030050, hsa_circRNA_100812 and hsa_circRNA_406168 was confirmed by qRT-PCR. Enrichment analysis revealed the association of hsa_circRNA_402130 and hsa_circRNA_072701 with multiple signaling pathways." 1 Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia. - - hsa_circRNA_030050 DOID:14227 azoospermia non-obstructive azoospermia "RT-qPCR, microarray" up-regulated "The differential expression of hsa_circRNA_402130, hsa_circRNA_072697, hsa_circRNA_030050, hsa_circRNA_100812 and hsa_circRNA_406168 was confirmed by qRT-PCR. Enrichment analysis revealed the association of hsa_circRNA_402130 and hsa_circRNA_072702 with multiple signaling pathways." 1 Upregulation of Circular RNA circATRNL1 to Sensitize Oral Squamous Cell Carcinoma to Irradiation. - hsa_circ_ATRNL1 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RNA-seq down-regulated circANTRL1 may function as the sponge of miR-23a-3p to promote PTEN expression and eventually contributes to OSCC radiosensitivity enhancement. This study indicates that circANTRL1 may be a novel therapeutic target to improve the efficiency of radiotherapy in OSCC. 1 Circ-HOMER1 enhances the inhibition of miR-1322 on CXCL6 to regulate the growth and aggressiveness of hepatocellular carcinoma cells. - hsa_circ_HOMER1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated we found that circ-HOMER1 promoted HCC cell growth and aggressiveness by miR-1322/CXCL6 axis. This study may provide a potential prognostic indicator and therapeutic target for patients with HCC. 2 Circular RNA expression profile and its potential regulative role in human abdominal aortic aneurysm. hsa_circ_0005360 - hsa_circ_0005360 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, RNA-seq" down-regulated This study revealed new circRNAs potentially related to the pathogenesis of AAA. Further experimental studies are warranted to clarify the potential molecular mechanisms. 1 Circular RNA expression profile and its potential regulative role in human abdominal aortic aneurysm. hsa_circ_0002168 - hsa_circ_0002168 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, RNA-seq" down-regulated This study revealed new circRNAs potentially related to the pathogenesis of AAA. Further experimental studies are warranted to clarify the potential molecular mechanisms. 1 Circular RNA expression profile and its potential regulative role in human abdominal aortic aneurysm. hsa_circ_0060063 - hsa_circ_0060063 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, RNA-seq" up-regulated This study revealed new circRNAs potentially related to the pathogenesis of AAA. Further experimental studies are warranted to clarify the potential molecular mechanisms. 1 Circular RNA expression profile and its potential regulative role in human abdominal aortic aneurysm. hsa_circ_0070382 - hsa_circ_0070382 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, RNA-seq" up-regulated This study revealed new circRNAs potentially related to the pathogenesis of AAA. Further experimental studies are warranted to clarify the potential molecular mechanisms. 1 Circular RNA expression profile and its potential regulative role in human abdominal aortic aneurysm. hsa_circ_0027446 - hsa_circ_0027446 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, RNA-seq" down-regulated This study revealed new circRNAs potentially related to the pathogenesis of AAA. Further experimental studies are warranted to clarify the potential molecular mechanisms. 1 Circular RNA expression profile and its potential regulative role in human abdominal aortic aneurysm. hsa_circ_0028198 - hsa_circ_0028198 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, RNA-seq" down-regulated This study revealed new circRNAs potentially related to the pathogenesis of AAA. Further experimental studies are warranted to clarify the potential molecular mechanisms. 1 A Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 Levels. - hsa_circ_MDM2 - DOID:9256 colorectal cancer colorectal cancer RNA-seq up-regulated Our results on the initial characterization of circ-MDM2 identify a new player from the MDM2 locus that suppresses p53 levels and cell cycle progression. 1 circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway. hsa_circ_0000140 - circRNA_0000140 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "mechanistic studies showed that circ_0000140 could bind with miR-31 and up-regulate its target gene LATS2, thus affecting OSCC cellular EMT. Our findings demonstrated the roles of circ_0000140 in OSCC tumorigenesis as well as in metastasis, and circ_0000140 exerts its tumor-suppressing effect through miR-31/LATS2 axis of Hippo signaling pathway in OSCC." 2 Circular RNA circ-Ttc3 protects HaCaT cells from hypoxic injury by downregulation of miR-449a. - hsa_circ_Ttc3 - DOID:8717 decubitus ulcer pressure ulcer RT-qPCR up-regulated Our data suggested that circ-Ttc3 alleviated hypoxic injury and activated NF-kappaB and PI3K/AKT pathways by downregulating miR-449a in HaCaT cells. 1 Circular RNA expression profiles and bioinformatic analysis in coronary heart disease. hsa_circ_0006251 - hsa_circ_0006251 DOID:3393 coronary artery disease coronary heart disease RT-qPCR up-regulated "hsa_circ_0006251 was upregulated, and hsa_circ_0003915, hsa_circ_0012721, hsa_circ_0103771, hsa_circ_0066529 and hsa_circ_0030042 were downregulated. " 1 Circular RNA expression profiles and bioinformatic analysis in coronary heart disease. hsa_circ_0003915 - hsa_circ_0003915 DOID:3393 coronary artery disease coronary heart disease RT-qPCR down-regulated "hsa_circ_0006251 was upregulated, and hsa_circ_0003915, hsa_circ_0012721, hsa_circ_0103771, hsa_circ_0066529 and hsa_circ_0030043 were downregulated." 1 Circular RNA expression profiles and bioinformatic analysis in coronary heart disease. hsa_circ_0012721 - hsa_circ_0012721 DOID:3393 coronary artery disease coronary heart disease RT-qPCR down-regulated "hsa_circ_0006251 was upregulated, and hsa_circ_0003915, hsa_circ_0012721, hsa_circ_0103771, hsa_circ_0066529 and hsa_circ_0030044 were downregulated." 1 Circular RNA expression profiles and bioinformatic analysis in coronary heart disease. hsa_circ_0103771 - hsa_circ_0103771 DOID:3393 coronary artery disease coronary heart disease RT-qPCR down-regulated "hsa_circ_0006251 was upregulated, and hsa_circ_0003915, hsa_circ_0012721, hsa_circ_0103771, hsa_circ_0066529 and hsa_circ_0030045 were downregulated." 1 Circular RNA expression profiles and bioinformatic analysis in coronary heart disease. hsa_circ_0066529 - hsa_circ_0066529 DOID:3393 coronary artery disease coronary heart disease RT-qPCR down-regulated "hsa_circ_0006251 was upregulated, and hsa_circ_0003915, hsa_circ_0012721, hsa_circ_0103771, hsa_circ_0066529 and hsa_circ_0030046 were downregulated." 1 Circular RNA expression profiles and bioinformatic analysis in coronary heart disease. hsa_circ_0030042 - hsa_circ_0030042 DOID:3393 coronary artery disease coronary heart disease RT-qPCR down-regulated "hsa_circ_0006251 was upregulated, and hsa_circ_0003915, hsa_circ_0012721, hsa_circ_0103771, hsa_circ_0066529 and hsa_circ_0030047 were downregulated." 1 CircRBM33 regulates IL-6 to promote gastric cancer progression through targeting miR-149. - hsa_circ_RBM33 hsa_circ_0001772 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circRBM33 manipulates biological function in GC cells through the circRBM33/miR-149/IL-6 axis. CircRBM33 can be used as a tumor biomarker and a possible therapeutic target in the future. 1 Neisseria gonorrhoeae-induced salpingitis is targeted by circular RNA EIF3K via miR-139-5p and regulating MAPK/NF-kappaB signaling pathway to promotes apoptosis and autophagy bacterial cells. - hsa_circ_EIF3K - DOID:5733 salpingitis salpingitis RT-qPCR down-regulated Neisseria gonorrhoeae-induced salpingitis is targeted by circular RNA EIF3K via miR-139-5p and regulating MAPK/NF-kappaB signaling pathway to promotes apoptosis and autophagy bacterial cells. 1 Hsa_circ_CSPP1/MiR-361-5p/ITGB1 Regulates Proliferation and Migration of Cervical Cancer (CC) by Modulating the PI3K-Akt Signaling Pathway. - hsa_circ_CSPP1 Hsa_circ_CSPP1 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Circular RNA hsa_circ_CSPP1 regulates cell migration and proliferation in cervical cancer through miR-361-5p/ITGB1 in PI3K-Akt signaling pathway. 1 Circular RNA-ITCH Inhibits the Proliferation of Ovarian Carcinoma by Downregulating lncRNA HULC. - hsa_circ_ITCH circular RNA-ITCH DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated circular RNA-ITCH may inhibit the proliferation of ovarian carcinoma by downregulating HULC. 4 CircHIPK3 promotes colorectal cancer cells proliferation and metastasis via modulating of miR-1207-5p/FMNL2 signal. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circHIPK3 promoted CRC cells migration, invasion and proliferation modulating of FMNL2 by sponging of miR-1207-5p. Our findings indicated that circHIPK3/miR-1207-5p/FMNL2 axis might be a new strategy in molecular treatment of CRC." 2 Circular RNA-0072309 has antitumor influences in Hep3B cell line by targeting microRNA-665. hsa_circ_0072309 - circRNA-0072309 DOID:3571 liver cancer liver cancer RT-qPCR down-regulated The circRNA-0072309 had antitumor influences in Hep3B cell line through targeting miR-665 relying on the deactivation of PI3K/AKT and Wnt/beta-catenin pathways. 1 Circular RNA PVT1 enhances cell proliferation but inhibits apoptosis through sponging microRNA-149 in epithelial ovarian cancer. hsa_circ_0001821 hsa_circ_TCONS_00015354 - DOID:2152 ovary epithelial cancer epithelial ovarian cancer RT-qPCR up-regulated "Circ-PVT1 enhances cell proliferation but inhibits cell apoptosis through sponging miR-149 in EOC cells, which suggests that circ-PVT1 may serve as a treatment target in EOC." 1 Circular RNA hsa_circ_0056836 functions an oncogenic gene in hepatocellular carcinoma through modulating miR-766-3p/FOSL2 axis. hsa_circ_0056836 hsa_circ_None - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated the hsa_circ_0056836 / miR-766-3p / FOSL2 axis may serve as a promising strategy for HCC treatment. 3 CircRNA hsa_circ_0004771 promotes esophageal squamous cell cancer progression via miR-339-5p/CDC25A axis. hsa_circ_0004771 hsa_circ_NRIP1 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "The upregulation of hsa_circ_0004771 was correlated with heavier tumor burden and poor prognosis, knockdown of it inhibited the ESCC cells proliferation both in vitro and in vivo. Mechanistically, hsa_circ_0004771 positively regulated CDC25A by acting as a molecular sponge of miR-339-5p ." 2 Downregulated expression of hsa_circ_0037515 and hsa_circ_0037516 as novel biomarkers for non-small cell lung cancer. hsa_circ_0037515 hsa_circ_ABCA3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "ABCA3 mRNA, hsa_circ_0037515, and hsa_circ_0037516 are significantly downregulated in 61 paired samples of NSCLC compared to adjacent lung tissues." 2 Downregulated expression of hsa_circ_0037515 and hsa_circ_0037516 as novel biomarkers for non-small cell lung cancer. hsa_circ_0037516 hsa_circ_ABCA3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "ABCA3 mRNA, hsa_circ_0037515, and hsa_circ_0037516 are significantly downregulated in 61 paired samples of NSCLC compared to adjacent lung tissues." 2 Circ-0001313/miRNA-510-5p/AKT2 axis promotes the development and progression of colon cancer. hsa_circ_0001313 hsa_circ_CCDC66 - DOID:219 colon cancer colon cancer "RT-qPCR, microarray" up-regulated "we confirmed that circ-0001313 competitively bound to miRNA-510-5p, thus upregulating its target gene AKT2. Moreover, western blot analyses revealed that circ-0001313 also affects the expression of Bcl-2 family proteins and the activation of PI3K/Akt signaling pathway. " 2 Identification of downregulated circRNAs from tissue and plasma of patients with gastric cancer and construction of a circRNA-miRNA-mRNA network. hsa_circ_0001190 hsa_circ_DYRK1A - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "A total of three downregulated circRNAs (hsa_circ_0001190, hsa_circ_0036287, and hsa_circ_0048607) were identified in this study. " 2 Identification of downregulated circRNAs from tissue and plasma of patients with gastric cancer and construction of a circRNA-miRNA-mRNA network. hsa_circ_0036287 hsa_circ_CLK3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "A total of three downregulated circRNAs (hsa_circ_0001190, hsa_circ_0036287, and hsa_circ_0048607) were identified in this study. " 1 Identification of downregulated circRNAs from tissue and plasma of patients with gastric cancer and construction of a circRNA-miRNA-mRNA network. hsa_circ_0048607 hsa_circ_CHAF1A - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "A total of three downregulated circRNAs (hsa_circ_0001190, hsa_circ_0036287, and hsa_circ_0048607) were identified in this study. " 1 Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion. - hsa_circ_FNTA - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "A clinical BCa sample survey shows that circFNTA expression is elevated in BCa tissues, and results from a BCa mouse model indicate that depletion of circFNTA leads to the suppression of BCa metastases and increased cisplatin chemo-sensitivity." 1 Circular RNA cZNF292 silence alleviates OGD/R-induced injury through up-regulation of miR-22 in rat neural stem cells (NSCs). - rno_circ_ZNF292 cZNF292 DOID:936 brain disease hypoxic-ischaemic encephalopathy RT-qPCR up-regulated silencing cZNF292 attenuated OGD/R-induced NSCs injury and promoted the activation of Wnt/beta-catenin and PKC/ERK pathways via the up-regulation of miR-22. 1 Antagonizing circRNA_002581-miR-122-CPEB1 axis alleviates NASH through restoring PTEN-AMPK-mTOR pathway regulated autophagy. - - CircRNA_002581 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, RNA-seq" up-regulated CPEB1-PTEN-AMPK-mTOR pathway is shown to link the autophagy and circRNA_002581 knockdown-mediated NASH alleviation. CircRNA_002581-miR-122-CPEB1 axis actively participates in the pathogenesis of NASH through PTEN-AMPK-mTOR pathway-related autophagy suppression. Targeting circRNA_002581 is a potential therapeutic strategy for NASH through partial autophagy restoration. 1 Circular RNA Profiling Reveals Exosomal circ_0006156 as a Novel Biomarker in Papillary Thyroid Cancer. hsa_circ_0006156 hsa_circ_FNDC3B - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, RNA-seq, microarray" up-regulated our study demonstrated that circFNDC3B modulates PTC progression through the miR-1178/TLR4 pathway. Our findings indicated that circFNDC3B may serve as a promising therapeutic target for the treatment of PTC patients. 1 circRASSF2 Acts as ceRNA and Promotes Papillary Thyroid Carcinoma Progression through miR-1178/TLR4 Signaling Pathway. - hsa_circ_RASSF2 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated our study demonstrates that circRASSF2 modulates PTC progression through the miR-1178/TLR4 pathway. Our findings indicate that circRASSF2 may serve as a promising therapeutic target for the treatment of PTC patients. 2 Circular RNA hsa_circ_0014130 Inhibits Apoptosis in Non-Small Cell Lung Cancer by Sponging miR-136-5p and Upregulating BCL2. hsa_circ_0014130 hsa_circ_PIP5K1A - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated hsa_circ_0014130 functions as a tumor promoter in NSCLC to promote tumor growth through upregulating Bcl-2 partially via sponging miR-136-5p. 4 Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1. - hsa_circ_CRIM1 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, RNA-seq" up-regulated "circCRIM1 competitively bound to miR-422a and prevented the suppressive effects of miR-422a on its target gene FOXQ1, which finally led to NPC metastasis, EMT and docetaxel chemoresistance." 2 Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke. - mmu_circ_HIPK2 - DOID:6713 cerebrovascular disease ischemic stroke "RT-qPCR, RNA-seq" up-regulated Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke. 1 [Association between circular RNAs expression in serum and gastric cancer]. - - hsa_circ_002059 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our study preliminarily suggested that the expression of hsa_circ_002059, hsa_circ_0000096 and hsa_circ_0001895 in serum might be correlated with gastric cancer." 2 [Association between circular RNAs expression in serum and gastric cancer]. hsa_circ_0000096 hsa_circ_HIAT1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our study preliminarily suggested that the expression of hsa_circ_002059, hsa_circ_0000096 and hsa_circ_0001895 in serum might be correlated with gastric cancer." 3 [Association between circular RNAs expression in serum and gastric cancer]. hsa_circ_0001895 hsa_circ_PRRC2B - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our study preliminarily suggested that the expression of hsa_circ_002059, hsa_circ_0000096 and hsa_circ_0001895 in serum might be correlated with gastric cancer." 2 Circular RNA (circ-0075804) promotes the proliferation of retinoblastoma via combining heterogeneous nuclear ribonucleoprotein K (HNRNPK) to improve the stability of E2F transcription factor 3 E2F3. hsa_circ_0075804 - circ-0075804 DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated "circ-0075804 promotes the proliferation of RB via combining HNRNPK to improve the stability of E2F3, which brings new light for treating RB." 3 Cancer stem cell-specific expression profiles reveal emerging bladder cancer biomarkers and identify circRNA_103809 as an important regulator in bladder cancer. - - CircRNA_103809 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "CircRNA_103809, the top one among the highly expressed circRNA identified in BCSCs, promotes the self-renewal, migration and invasion capabilities of bladder cancer by acting as a miR-511 sponge." 1 Circular RNA-0001283 Suppresses Breast Cancer Proliferation and Invasion via MiR-187/HIPK3 Axis. hsa_circ_0001283 - circRNA-0001283 DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "Ectopic expression of circRNA-0001283 remarkably suppressed cell viability and invasion, and induced apoptosis in breast cancer cells. Furthermore, circRNA-0001283 bound to miR-187 and decreased the expression of miR-187, which resulted in inhibition in cell growth and invasion. Finally, we showed that circRNA-0001283 positively regulated HIPK3 expression by sponging miR-187." 1 circRNA circFUT8 Upregulates Krupple-like Factor 10 to Inhibit the Metastasis of Bladder Cancer via Sponging miR-570-3p. hsa_circ_0003028 hsa_circ_FUT8 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" down-regulated circFUT8 functions as a tumor suppressor in BCa cells by targeting the miR-570-3p/KLF10 axis and may serve as a potential biomarker and therapeutic target for the management of BCa patients with LN metastasis. 1 Circ_PUM1 promotes the development of endometrial cancer by targeting the miR-136/NOTCH3 pathway. - hsa_circ_PUM1 circ_PUM1 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "Circ_PUM1 is capable of binding to miR-136, and up-regulating its target gene NOTCH3, which can be reversed by overexpression of miR-136. Circ_PUM1 can compete with miR-136, leading to up-regulation of NOTCH3, and thereby promote the development of endometrial cancer." 2 hsa_circ_0000092 promotes hepatocellular carcinoma progression through up-regulating HN1 expression by binding to microRNA-338-3p. hsa_circ_0000092 hsa_circ_RPL5 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "The results of this study suggested that hsa_circ_0000092 impaired miR-338-3p-mediated HN1 inhibition to aggravate the development of HCC, indicating that hsa_circ_0000092 is a potential candidate marker and therapeutic target for HCC." 1 RNA-Seq profiling of circular RNAs in human small cell lung cancer. - hsa_circ_STXBP5L circ-STXBP5L DOID:5409 lung small cell carcinoma small cell lung cancer "RT-qPCR, RNA-seq" up-regulated "The five upregulated circRNAs: circ-THRAP3, circ-SEC31A, circ-SATB1, circ-VAPA and circ-STXBP5L were confirmed to be upregulated in nearly 100% of SCLC tissues by qRT-PCR." 1 RNA-Seq profiling of circular RNAs in human small cell lung cancer. - hsa_circ_THRAP3 circ-THRAP3 DOID:5409 lung small cell carcinoma small cell lung cancer "RT-qPCR, RNA-seq" up-regulated "The five upregulated circRNAs: circ-THRAP3, circ-SEC31A, circ-SATB1, circ-VAPA and circ-STXBP5L were confirmed to be upregulated in nearly 100% of SCLC tissues by qRT-PCR." 1 RNA-Seq profiling of circular RNAs in human small cell lung cancer. - hsa_circ_SEC31A circ-SEC31A DOID:5409 lung small cell carcinoma small cell lung cancer "RT-qPCR, RNA-seq" up-regulated "The five upregulated circRNAs: circ-THRAP3, circ-SEC31A, circ-SATB1, circ-VAPA and circ-STXBP5L were confirmed to be upregulated in nearly 100% of SCLC tissues by qRT-PCR." 1 RNA-Seq profiling of circular RNAs in human small cell lung cancer. - hsa_circ_SATB1 circ-SATB1 DOID:5409 lung small cell carcinoma small cell lung cancer "RT-qPCR, RNA-seq" up-regulated "The five upregulated circRNAs: circ-THRAP3, circ-SEC31A, circ-SATB1, circ-VAPA and circ-STXBP5L were confirmed to be upregulated in nearly 100% of SCLC tissues by qRT-PCR." 1 RNA-Seq profiling of circular RNAs in human small cell lung cancer. - hsa_circ_VAPA circ-VAPA DOID:5409 lung small cell carcinoma small cell lung cancer "RT-qPCR, RNA-seq" up-regulated "The five upregulated circRNAs: circ-THRAP3, circ-SEC31A, circ-SATB1, circ-VAPA and circ-STXBP5L were confirmed to be upregulated in nearly 100% of SCLC tissues by qRT-PCR." 1 The circ_VCAN with radioresistance contributes to the carcinogenesis of glioma by regulating microRNA-1183. hsa_circ_0073237 hsa_circ_VCAN - DOID:0060108 brain glioma glioma RT-qPCR down-regulated "overexpression of circ_VCAN expedited carcinogenesis and reduced glioma radiosensitivity by regulating miR-1183.Circ_VCAN serves as a potential oncogene of glioma by regulating miR-1183, and plays an essential role in the radioresistance of glioma." 3 Expression profiles of circular RNA in granulosa cells from women with biochemical premature ovarian insufficiency. - - hsa_circ_003785 DOID:1100 ovarian disease premature ovarian insufficiency "RT-qPCR, microarray" up-regulated "The expression levels of hsa_circ_003785 and hsa_circ_103903 were upregulated and hsa_circ_008389 was downregulated in the bPOI group, consistent with qRT-PCR." 1 Expression profiles of circular RNA in granulosa cells from women with biochemical premature ovarian insufficiency. hsa_circ_008389 - hsa_circ_008389 DOID:1100 ovarian disease premature ovarian insufficiency "RT-qPCR, microarray" down-regulated "The expression levels of hsa_circ_003785 and hsa_circ_103903 were upregulated and hsa_circ_008389 was downregulated in the bPOI group, consistent with qRT-PCR." 1 Hsa_circ_0011385 accelerates the progression of thyroid cancer by targeting miR-361-3p. hsa_circ_0011385 hsa_circ_EIF3I - DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "Hsa_circ_0011385facilitated thyroid cancer cell proliferation, invasion and migration, and inhibited thyroid cancer cell cycle arrest and apoptosis by targeting miR-361-3p, suggesting that the hsa_circ_0011385/miR-361-3p axis might be a promising therapeutic target for thyroid cancer." 1 CircRNA_0001449 disturbs phosphatidylinositol homeostasis and AKT activity by enhancing Osbpl5 translation in transient cerebral ischemia. hsa_circ_0001449 hsa_circ_ARHGAP10 - DOID:2316 brain ischemia cerebral ischemia RNA-seq up-regulated RNA sequencing and RNA pull down analyses confirmed a competing endogenous RNA pathway in which circ_0001449 sponges miR-124-3p and miR-32-5p to promote Osbpl5 translation. Our data showed that circRNA_0001449 regulates membrane homeostasis via ORP5 and is involved in the AKT survival pathway. 1 Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis. hsa_circ_0076906 hsa_circ_PRIM2 - DOID:11476 osteoporosis osteoporosis RT-qPCR down-regulated Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis. 1 "Circ-PRMT5 enhances the proliferation, migration and glycolysis of hepatoma cells by targeting miR-188-5p/HK2 axis." hsa_circ_0031242 hsa_circ_PRMT5 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "In summary, circ-PRMT5 might play a key role in proliferation, migration, glycolysis of HCC cells via miR-188-5p/HK2 axis, which indicated that circ-PRMT5 might be a potential therapeutic target for HCC treatment." 3 Circular RNA hsa_circ_0000467 Promotes the Development of Gastric Cancer by Competitively Binding to MicroRNA miR-326-3p. hsa_circ_0000467 hsa_circ_SKA3 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "hsa_circ_0000467 plays a regulatory role in the development and progression of gastric cancer by regulating miR-326-3p, and this circRNA may be a potential diagnostic marker and therapeutic target of gastric cancer." 3 Next-generation sequencing to investigate circular RNA profiles in the peripheral blood of preterm neonates with bronchopulmonary dysplasia. hsa_circ_0005577 hsa_circ_TIAL1 - DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0005577 (hsa_circ_FANCL), which was significantly increased in the moderate-to-severe BPD subjects, was correlated with oxygenation therapy." 1 CircAP2A2 acts as a ceRNA to participate in infantile hemangiomas progression by sponging miR-382-5p via regulating the expression of VEGFA. - hsa_circ_AP2A2 - DOID:255 hemangioma infantile hemangioma RT-qPCR up-regulated "CircAP2A2 was confirmed to be highly expressed in IH. CircAP2A2 knockdown or miR-382-5p overexpression decreased the proliferation, colony formation, migration, and invasion of HemECs and HUVEC cells. CONCLUSION: CircAP2A2 could promote proliferation and invasion of IH by regulating miR-382-5p/VEGFA axis." 1 Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus. hsa_circ_0000479 hsa_circ_EPSTI1 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR up-regulated "The result showed that the expression levels of hsa_circ_0000479, hsa_circ_0082688, hsa_circ_0082689, hsa_circ_0008529, and hsa_circ_0003694 were significantly increased in PBMCs from SLE patients than those in HC. On the contrary, the expression levels of hsa_circ_0002316, hsa_circ_0000317, and hsa_circ_0000175 in PBMCs from SLE patients were significantly decreased compared with HC." 2 Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus. hsa_circ_0082688 hsa_circ_PARP12 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR up-regulated "The result showed that the expression levels of hsa_circ_0000479, hsa_circ_0082688, hsa_circ_0082689, hsa_circ_0008529, and hsa_circ_0003694 were significantly increased in PBMCs from SLE patients than those in HC. On the contrary, the expression levels of hsa_circ_0002316, hsa_circ_0000317, and hsa_circ_0000176 in PBMCs from SLE patients were significantly decreased compared with HC." 4 Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus. hsa_circ_0082689 hsa_circ_PARP12 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR up-regulated "The result showed that the expression levels of hsa_circ_0000479, hsa_circ_0082688, hsa_circ_0082689, hsa_circ_0008529, and hsa_circ_0003694 were significantly increased in PBMCs from SLE patients than those in HC. On the contrary, the expression levels of hsa_circ_0002316, hsa_circ_0000317, and hsa_circ_0000177 in PBMCs from SLE patients were significantly decreased compared with HC." 4 Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus. hsa_circ_0008529 hsa_circ_ACTR2 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR up-regulated "The result showed that the expression levels of hsa_circ_0000479, hsa_circ_0082688, hsa_circ_0082689, hsa_circ_0008529, and hsa_circ_0003694 were significantly increased in PBMCs from SLE patients than those in HC. On the contrary, the expression levels of hsa_circ_0002316, hsa_circ_0000317, and hsa_circ_0000178 in PBMCs from SLE patients were significantly decreased compared with HC." 1 Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus. hsa_circ_0003694 hsa_circ_SMAD2 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR up-regulated "The result showed that the expression levels of hsa_circ_0000479, hsa_circ_0082688, hsa_circ_0082689, hsa_circ_0008529, and hsa_circ_0003694 were significantly increased in PBMCs from SLE patients than those in HC. On the contrary, the expression levels of hsa_circ_0002316, hsa_circ_0000317, and hsa_circ_0000179 in PBMCs from SLE patients were significantly decreased compared with HC." 1 Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus. hsa_circ_0002316 hsa_circ_OMA1 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR down-regulated "The result showed that the expression levels of hsa_circ_0000479, hsa_circ_0082688, hsa_circ_0082689, hsa_circ_0008529, and hsa_circ_0003694 were significantly increased in PBMCs from SLE patients than those in HC. On the contrary, the expression levels of hsa_circ_0002316, hsa_circ_0000317, and hsa_circ_0000180 in PBMCs from SLE patients were significantly decreased compared with HC." 1 Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus. hsa_circ_0000317 hsa_circ_AHNAK - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR down-regulated "The result showed that the expression levels of hsa_circ_0000479, hsa_circ_0082688, hsa_circ_0082689, hsa_circ_0008529, and hsa_circ_0003694 were significantly increased in PBMCs from SLE patients than those in HC. On the contrary, the expression levels of hsa_circ_0002316, hsa_circ_0000317, and hsa_circ_0000181 in PBMCs from SLE patients were significantly decreased compared with HC." 1 Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus. hsa_circ_0000175 hsa_circ_ELK4 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR down-regulated "The result showed that the expression levels of hsa_circ_0000479, hsa_circ_0082688, hsa_circ_0082689, hsa_circ_0008529, and hsa_circ_0003694 were significantly increased in PBMCs from SLE patients than those in HC. On the contrary, the expression levels of hsa_circ_0002316, hsa_circ_0000317, and hsa_circ_0000182 in PBMCs from SLE patients were significantly decreased compared with HC." 1 Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1alpha/HK2. - hsa_circ_RNF20 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "circRNF20 harbor miR-487a, acting as miRNA sponge, and then miR-487a targeted the 3-UTR of hypoxia-inducible factor-1alpha (HIF-1alpha). Moreover, HIF-1alpha could bind with the promoter of hexokinase II (HK2) and promoted its transcription. In conclusion, this finding illustrates the vital roles of circRNF20 via the circRNF20/ miR-487a/HIF-1alpha/HK2 axis in breast cancer progress and Warburg effect, providing an interesting insight for the BC tumorigenesis." 1 "Circular RNA hsa_circ_0011946 promotes cell growth, migration, and invasion of oral squamous cell carcinoma by upregulating PCNA." hsa_circ_0011946 hsa_circ_SCMH1 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Hsa_circ_0011946 could promote cell growth, migration, and invasion of OSCC by upregulating PCNA, which may offer a new therapeutic intervention for OSCC patients." 3 Circular RNA circ-ABCB10 promotes the proliferation and invasion of thyroid cancer by targeting KLF6. - hsa_circ_ABCB10 circ-ABCB10 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "Circ-ABCB10 was first identified as a novel oncogene in thyroid cancer. Furthermore, it significantly enhanced the proliferation and invasion of thyroid cancer by targeting KLF6. Our findings suggested that circ-ABCB10 could be used as a potential therapeutic target in thyroid cancer." 1 Upregulation of circular SMAD7 inhibits tumorigenesis of gastric cancer by reversing epithelial-to-mesenchymal transition. - hsa_circ_SMAD7 circ-SMAD7 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated These results indicate that upregulation of circ-SMAD7 inhibits GC cell migration and invasion via reversing the EMT process. 1 Circular RNA hsa_circ_0010882 promotes the progression of gastric cancer via regulation of the PI3K/Akt/mTOR signaling pathway. hsa_circ_0010882 hsa_circ_RPL11 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Hsa_circ_0010882, as an oncogenic molecule, is highly expressed in the plasma of patients with GC and is associated with poor prognosis. It plays an important role in proliferation, migration, and invasive genotypes of GC cell lines via regulation of the PI3K/Akt/mTOR signaling pathway. Additionally, it might be a potential prognostic biomarker for GC patients." 1 Circular RNA hsa_circ_0017247 acts as an oncogene in bladder cancer by inducing Wnt/beta-catenin signaling pathway. hsa_circ_0017247 hsa_circ_AKT3 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated Circular RNA hsa_circ_0017247 acts as an oncogene in bladder cancer by inducing Wnt/beta-catenin signaling pathway. 1 The circular RNA NT5E promotes non-small cell lung cancer cell growth via sponging microRNA-134. - hsa_circ_NT5E - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated The circular RNA NT5E promotes non-small cell lung cancer cell growth via sponging microRNA-134. 1 Circular RNA TUBD1 Acts as the miR-146a-5p Sponge to Affect the Viability and Pro-Inflammatory Cytokine Production of LX-2 Cells through the TLR4 Pathway. - hsa_circ_TUBD1 - DOID:409 liver disease radiation-induced liver disease RT-qPCR up-regulated "Mechanistic analysis suggested that circTUBD1 acted as the miR-146a-5p sponge to affect pro-inflammatory cytokine production through regulating expression of Toll-like receptor 4 (TLR4), interleukin receptor-associated kinase 1 (IRAK1), tumor necrosis factor receptor-associated factor-6 (TRAF6), and phosphorylation of nuclear factor-kappa B (pNF-kappaB) in irradiated and LPS-stimulated LX-2 cells. " 2 Circular RNA circ_0006282 Contributes to the Progression of Gastric Cancer by Sponging miR-155 to Upregulate the Expression of FBXO22. hsa_circ_0006282 hsa_circ_TCEB1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our findings indicated that over-expression of circ_0006282 down_regulated miR-155 to activate the expression of FBXO22, thus promoting proliferation and metastasis of GC cells, which provides a promising therapeutic target for GC treatment." 3 circPCNX and Pecanex Promote Hepatocellular Carcinoma Cell Viability by Inhibiting miR-506. hsa_circ_0032388 hsa_circ_PCNX - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "We propose that circPCNX and PCNX are new prognostic markers for HCC. Based on our findings, circPCNX and PCNX may promote HCC progression by regulating miR-506." 1 Hsa_circ_0003159 inhibits gastric cancer progression by regulating miR-223-3p/NDRG1 axis. hsa_circ_0003159 hsa_circ_CACNA2D1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Hsa_circ_0003159 suppressed proliferation, migration, invasion and xenograft tumor growth but promoted apoptosis by decreasing miR-223-3p and increasing NDRG1 in GC, indicating a novel target for treatment of GC." 3 Circular RNA-CDR1as acts as the sponge of microRNA-641 to promote osteoarthritis progression. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated our results indicate that circRNA-CDR1as plays a crucial role in regulating OA progression via modulating extracellular matrix metabolism and inflammation via sponging miR-641 and provide a novel regulatory role of circRNA-CDR1as in OA. 2 Circ-MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self-Renewal of Hepatocellular Cancer Stem Cells. hsa_circ_0004287 hsa_circ_MALAT1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circMALAT1 functions as a brake in ribosomes to retard PAX5 mRNA translation and promote CSCs self-renewal by forming an unprecedented ternary complex with both ribosomes and mRNA. 1 CircHIPK3 Promotes Gemcitabine (GEM) Resistance in Pancreatic Cancer Cells by Sponging miR-330-5p and Targets RASSF1. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "CircHIPK3 promotes gemcitabine (GEM) resistance in pancreatic cancer cells by targeting RASSF1 via miR-330-5p and regulates proliferation, invasive, migration, EMT, and apoptosis. Our research revealed that circHIPK3 may be a novel biomarker in GEM-resistant PC and could be used as a prognostic target." 2 CircPRKCI relieves lipopolysaccharide-induced HK2 cell injury by upregulating the expression of miR-545 target gene ZEB2. - hsa_circ_PRKCI - DOID:4676 uremia uremia RT-qPCR down-regulated This research indicated that the highly expressed circPRKCI relieved inflammatory injury induced by LPS in HK2 cells by suppressing miR-545/ZEBs and depressing the briskness of NF-kB pathway. 1 Circ-IGF1R inhibits cell invasion and migration in non-small cell lung cancer. hsa_circ_0005035 hsa_circ_IGF1R - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" down-regulated "The overexpression of circ-IGF1R significantly inhibited the invasion and migration of the lung cancer cells. The potential network of circ-IGF1R-miR-1270-VANGL2 was preliminarily determined, and the expression patterns of miR-1270 and VANGL2 were verified in lung cancer cell lines. CONCLUSION: Circ-IGF1R may inhibit lung cancer invasion and migration through a potential network of circ-IGF1R-miR-1270-VANGL2." 1 "Circ_0058124 Upregulates MAPK1 Expression to Promote Proliferation, Metastasis and Metabolic Abilities in Thyroid Cancer Through Sponging miR-940." hsa_circ_0058124 - circ_0058124 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "Circ_0058124 Upregulates MAPK1 Expression to Promote Proliferation, Metastasis and Metabolic Abilities in Thyroid Cancer Through Sponging miR-940." 1 circHIPK3 Promotes Cell Proliferation and Migration of Gastric Cancer by Sponging miR-107 and Regulating BDNF Expression. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "circHIPK3 was identified as a sponge of miR-107, and as such it regulated brain-derived neurotrophic factor (BDNF), which plays a pivotal role in the development of GC." 6 circPVT1 Facilitates Invasion and Metastasis by Regulating miR-205-5p/c-FLIP Axis in Osteosarcoma. - hsa_circ_PVT1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Our study demonstrated circPVT1 functions as a sponge for miR-205-5p to promote c-FLIP expression, thereby enhancing EMT and inducing OS invasion and metastasis in vitro, implying that circPVT1 might be a potential therapeutic target for further clinical therapy of OS." 5 CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a. hsa_circ_0049116 hsa_circ_MUC16 - DOID:2152 ovary epithelial cancer epithelial ovarian cancer "RT-qPCR, microarray" up-regulated "circMUC16 could directly bind to miR-199a-5p and relieve suppression of target Beclin1 and RUNX1. In turn, RUNX1 elevated the expression of circMUC16 via promotion of its transcription. CircMUC16 could directly bind to ATG13 and promote its expression." 1 Analysis of differentially expressed circular RNAs in endothelial cells under impinging flow. - - hsa_circRNA_103635 DOID:850 lung disease airway inflammation "RT-qPCR, microarray" up-regulated We present the differential expression profiles of circRNAs in ECs after the application of impinging flow; our results indicate that these differentially expressed circRNAs may be involved in inflammatory responses and damage in ECs. The present findings provide valuable information on cRNA profiles as well as clues for future studies that will investigate the roles that circRNAs play in ECs after inflammatory injury. 1 Analysis of differentially expressed circular RNAs in endothelial cells under impinging flow. - - hsa_circRNA_102511 DOID:850 lung disease airway inflammation "RT-qPCR, microarray" up-regulated We present the differential expression profiles of circRNAs in ECs after the application of impinging flow; our results indicate that these differentially expressed circRNAs may be involved in inflammatory responses and damage in ECs. The present findings provide valuable information on cRNA profiles as well as clues for future studies that will investigate the roles that circRNAs play in ECs after inflammatory injury. 1 Analysis of differentially expressed circular RNAs in endothelial cells under impinging flow. - - hsa_circRNA_405463 DOID:850 lung disease airway inflammation "RT-qPCR, microarray" up-regulated We present the differential expression profiles of circRNAs in ECs after the application of impinging flow; our results indicate that these differentially expressed circRNAs may be involved in inflammatory responses and damage in ECs. The present findings provide valuable information on cRNA profiles as well as clues for future studies that will investigate the roles that circRNAs play in ECs after inflammatory injury. 1 Analysis of differentially expressed circular RNAs in endothelial cells under impinging flow. - - hsa_circRNA_400049 DOID:850 lung disease airway inflammation "RT-qPCR, microarray" up-regulated We present the differential expression profiles of circRNAs in ECs after the application of impinging flow; our results indicate that these differentially expressed circRNAs may be involved in inflammatory responses and damage in ECs. The present findings provide valuable information on cRNA profiles as well as clues for future studies that will investigate the roles that circRNAs play in ECs after inflammatory injury. 1 Analysis of differentially expressed circular RNAs in endothelial cells under impinging flow. - - hsa_circRNA_101159 DOID:850 lung disease airway inflammation "RT-qPCR, microarray" down-regulated We present the differential expression profiles of circRNAs in ECs after the application of impinging flow; our results indicate that these differentially expressed circRNAs may be involved in inflammatory responses and damage in ECs. The present findings provide valuable information on cRNA profiles as well as clues for future studies that will investigate the roles that circRNAs play in ECs after inflammatory injury. 1 Analysis of differentially expressed circular RNAs in endothelial cells under impinging flow. - - hsa_circRNA_100778 DOID:850 lung disease airway inflammation "RT-qPCR, microarray" down-regulated We present the differential expression profiles of circRNAs in ECs after the application of impinging flow; our results indicate that these differentially expressed circRNAs may be involved in inflammatory responses and damage in ECs. The present findings provide valuable information on cRNA profiles as well as clues for future studies that will investigate the roles that circRNAs play in ECs after inflammatory injury. 1 Analysis of differentially expressed circular RNAs in endothelial cells under impinging flow. - - hsa_circRNA_006349 DOID:850 lung disease airway inflammation "RT-qPCR, microarray" down-regulated We present the differential expression profiles of circRNAs in ECs after the application of impinging flow; our results indicate that these differentially expressed circRNAs may be involved in inflammatory responses and damage in ECs. The present findings provide valuable information on cRNA profiles as well as clues for future studies that will investigate the roles that circRNAs play in ECs after inflammatory injury. 1 Analysis of differentially expressed circular RNAs in endothelial cells under impinging flow. - - hsa_circRNA_405324 DOID:850 lung disease airway inflammation "RT-qPCR, microarray" down-regulated We present the differential expression profiles of circRNAs in ECs after the application of impinging flow; our results indicate that these differentially expressed circRNAs may be involved in inflammatory responses and damage in ECs. The present findings provide valuable information on cRNA profiles as well as clues for future studies that will investigate the roles that circRNAs play in ECs after inflammatory injury. 1 Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-kappaB axis in endothelial cells. - hsa_circ_RELL1 - DOID:850 lung disease airway inflammation "RT-qPCR, microarray" up-regulated "circ-RELL1 directly bound to miR-6873-3p in cytoplasm. Subsequently miR-6873-3p reduced MyD88 (myeloid differentiation primary response 88) protein expression and alleviated MyD88 medicated NF-kappaB activation. Furthermore, circ-RELL1 can abolish the inhibition of inflammation response by miR-6873-3p. Our findings illustrate a novel regulatory pathway that circ-RELL1 modulate inflammatory response by miR-6873-3p/MyD88/NF-kappaB axis in ox-LDL induced endothelial cells, which provides a potential therapeutic candidate for endothelium inflammation in atherosclerotic cardiovascular disease." 1 CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. - hsa_circ_CIDN - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated "Our results revealed that circRNA-CIDN binding to miR-34a-5p played an important role in mitigating compression loading-induced nucleus pulposus cell damage via targeting SIRT1, providing a potential therapeutic strategy for IDD treatment." 1 circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells via Pyroptosis. - hsa_circ_ACTR2 - DOID:557 kidney disease diabetic nephropathy "RT-qPCR, microarray" up-regulated "our study identified a new circRNA, circACTR2, that regulates high glucose-induced pyroptosis, inflammation and fibrosis in proximal tubular cells. The present study preliminarily explores the role of circRNAs in pyroptosis of tubular cells, and provides novel insight into the pathogenesis of DKD and new therapeutic strategies." 1 Identification of functional circRNA/miRNA/mRNA regulatory network for exploring prospective therapy strategy of colorectal cancer. hsa_circ_0030632 hsa_circ_UGGT2 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "we validated the expression of the top four upregulated circRNAs (hsa_circ_0030632, hsa_circ_0004887, hsa_circ_0001550, and hsa_circ_0001681) in both of paired CRC tissues and CRC cell lines." 1 Identification of functional circRNA/miRNA/mRNA regulatory network for exploring prospective therapy strategy of colorectal cancer. hsa_circ_0004887 hsa_circ_AURKA - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "we validated the expression of the top four upregulated circRNAs (hsa_circ_0030632, hsa_circ_0004887, hsa_circ_0001550, and hsa_circ_0001682) in both of paired CRC tissues and CRC cell lines." 1 Identification of functional circRNA/miRNA/mRNA regulatory network for exploring prospective therapy strategy of colorectal cancer. hsa_circ_0001550 hsa_circ_RARS - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "we validated the expression of the top four upregulated circRNAs (hsa_circ_0030632, hsa_circ_0004887, hsa_circ_0001550, and hsa_circ_0001683) in both of paired CRC tissues and CRC cell lines." 2 Identification of functional circRNA/miRNA/mRNA regulatory network for exploring prospective therapy strategy of colorectal cancer. hsa_circ_0001681 hsa_circ_RAPGEF5 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "we validated the expression of the top four upregulated circRNAs (hsa_circ_0030632, hsa_circ_0004887, hsa_circ_0001550, and hsa_circ_0001684) in both of paired CRC tissues and CRC cell lines." 1 Oncogenic hsa_circ_0091581 promotes the malignancy of HCC cell through blocking miR-526b from degrading c-MYC mRNA. hsa_circ_0091581 hsa_circ_GPC3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated Oncogenic hsa_circ_0091581 promotes the malignancy of HCC cell through blocking miR-526b from degrading c-MYC mRNA. 4 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - - circ_40203 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" up-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 2 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - - circ_45876 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" up-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 1 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - - circ_24344 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" up-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 1 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - - circ_43956 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" up-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 1 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - - circ_37286 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" up-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 1 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - - circ_40203 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" up-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 2 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - - circ_38328 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" down-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 1 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - - circ_26316 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" down-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 1 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - - circ_41878 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" down-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 1 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - - circ_40795 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" down-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 1 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - - circ_003795 DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" down-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 1 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - hsa_circ_BBS2 - DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" down-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 1 Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke. - hsa_circ_PHKA2 - DOID:2316 brain ischemia acute ischemic stroke "RT-qPCR, microarray" down-regulated These results demonstrate that blood circRNAs may serve as potential biomarkers for AIS diagnosis and reveal the pathophysiological responses in the brain after ischemic stroke. 1 Circular RNA hsa_circ_0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation. hsa_circ_0084443 hsa_circ_PRKDC - DOID:10881 "hand, foot and mouth disease" diabetic foot ulcer "RT-qPCR, microarray" up-regulated "We identified hsa_circ_0084443, a circRNA downregulated during NW healing, as a negative regulator of keratinocyte migration. Higher levels of hsa_circ_0084443 were detected in DFU samples, suggesting that it plays a role in pathology. These findings pave the way to understanding the functional role of circRNAs in human skin wound healing." 1 CircRNA_103762 promotes multidrug resistance in NSCLC by targeting DNA damage inducible transcript 3 (CHOP). - - circRNA_103762 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Together, we demonstrated that circRNA_103762 is upregulated in NSCLC and functions as an oncogene in NSCLC, and circRNA_103762 enhanced MDR by inhibited CHOP expression in NSCLC cells. These results will help us understand the MDR of NSCLC, providing better effective therapy strategies for patients." 1 Circ_0000388 Exerts Oncogenic Function in Cervical Cancer Cells by Regulating miR-337-3p/TCF12 Axis. hsa_circ_0000388 - circ_0000388 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Circ_0000388 was a novel oncogenic circRNA in CC, and promoted cancer progression via regulating miR-337-3p and TCF12, and could be potentially used as a diagnostic biomarker and therapy target." 1 Expression and clinical significance of circular RNAs hsa_circ_0000175 and hsa_circ_0008410 in peripheral blood mononuclear cells from patients with rheumatoid arthritis. hsa_circ_0000175 hsa_circ_ELK4 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR down-regulated "PBMC hsa_circ_0000175, hsa_circ_0008410, and the combination of PBMC hsa_circ_0000175 and hsa_circ_0008410 may improve the diagnostic accuracy for RA. In addition, the expression levels of PBMC hsa_circ_0000175 and hsa_circ_0008410 were associated with disease activity and severity of RA." 2 Expression and clinical significance of circular RNAs hsa_circ_0000175 and hsa_circ_0008410 in peripheral blood mononuclear cells from patients with rheumatoid arthritis. hsa_circ_0008410 hsa_circ_PGS1 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "PBMC hsa_circ_0000175, hsa_circ_0008410, and the combination of PBMC hsa_circ_0000175 and hsa_circ_0008410 may improve the diagnostic accuracy for RA. In addition, the expression levels of PBMC hsa_circ_0000175 and hsa_circ_0008411 were associated with disease activity and severity of RA." 1 "Genome-wide, integrative analysis of circular RNA dysregulation and the corresponding circular RNA-microRNA-mRNA regulatory axes in autism." - hsa_circ_ARID1A - DOID:0060041 autism spectrum disorder autism spectrum disorder "RT-qPCR, RNA-seq, microarray" up-regulated "We further confirmed that some ASD risk genes (NLGN1, STAG1, HSD11B1, VIP, and UBA6) were regulated by an up-regulated circRNA (circARID1A) via sponging a down-regulated microRNA (miR-204-3p) in human neuronal cells. " 1 Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network. - - hsa_circRNA_102115 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma microarray up-regulated curcumin could enhance radiosensitization of NPC cell lines via mediating regulation of tumor stem-like cells by the hsa_circRNA_102115-hsa-miR-335-3p-MAPK1 interaction network. 1 Circular RNA 0060428 sponges miR-375 to promote osteosarcoma cell proliferation by upregulating the expression of RPBJ. hsa_circ_0060428 - circ-0060428 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circ-0060428 regulated the expression of apoptosis related proteins (Bax, Bcl-2, and cleaved-Caspase-3) by upregulating RPBJ expression in osteosarcoma cells. Altogether, we confirmed the up-regulated circ-0060428 could improve the proliferation and survival of osteosarcoma cells by sponging miR-375 to upregulate RBPJ expression. This finding supported a novel clinically biomarker and treatment target for osteosarcoma therapy." 1 CircRNA_0005075 suppresses carcinogenesis via regulating miR-431/p53/epithelial-mesenchymal transition axis in gastric cancer. hsa_circ_0005075 hsa_circ_EIF4G3 circ_RNA_0005075 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "The research clearly elucidated the potential role and relative regulatory mechanism of circRNA_0005075 in gastric cancer (GC) progression. Briefly, circRNA_0005075 could directly inhibit the expression level of miR-431, then regulate the p53/Epithelial-mesenchymal transition axis, and finally inhibit cell growth and metastasis in GC. Consequently, circRNA_0005075 might act as an oncogene in the GC procession, which provides a promising way for the treatment of GC." 4 Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7. - hsa_circ_RACGAP1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7. 1 Circ_0009910 promotes proliferation and metastasis of hepatocellular carcinoma cells through miR-335-5p/ROCK1 axis. hsa_circ_0009910 - Circ_0009910 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ_0009910-silenced suppressed the growth and metastasis of HCC cells through upregulating the inhibitory effect of miR-335-5p on ROCK1. 3 Circular RNA circ-SMAD7 is downregulated in colorectal cancer and suppresses tumor metastasis by regulating epithelial mesenchymal transition. - hsa_circ_SMAD7 circ-SMAD7 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "circ-SMAD7 could inhibit cell migration and invasion of CRC by suppressing the EMT process, which might offer a potential therapeutic target for CRC." 1 CircDDX17 reduces 5-fluorouracil resistance and hinders tumorigenesis in colorectal cancer by regulating miR-31-5p/KANK1 axis. - hsa_circ_DDX17 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Upregulation of circDDX17 strengthened chemosensitivity of CRC to 5-Fu and blocked CRC progression by regulating miR-31-5p/KANK1 axis, which might provide an effective treatment strategy for CRC patients." 2 Circular RNA hsa_circ_0012673 facilitates lung cancer cell proliferation and invasion via miR-320a/LIMK18521 axis. hsa_circ_0012673 hsa_circ_DHCR24 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Circ_0012673 was a tumor-promoter in lung cancer via acting as competing endogenous RNA to regulate LIMK1 expression by binding miR-320a. 2 Circular RNA_LARP4 inhibits the progression of non-small-cell lung cancer by regulating the expression of SMAD7. - hsa_circ_LARP4 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated Circ LARP4 could suppress the metastasis of NSCLC by up-regulating SMAD7. 4 "Circular RNA hsa_circ_0008039 promotes proliferation, migration and invasion of breast cancer cells through upregulating CBX4 via sponging miR-515-5p." hsa_circ_0008039 hsa_circ_PRKAR1B - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circular RNA hsa_circ_0008039 promotes proliferation, migration and invasion of breast cancer cells through upregulating CBX4 via sponging miR-515-5p." 2 Circular RNA circ_0017247 promotes melanoma migration and invasion via targeting miR-145. hsa_circ_0017247 - circ_0017247 DOID:1909 melanoma melanoma RT-qPCR up-regulated Circular RNA circ_0017247 promotes melanoma migration and invasion via targeting miR-145. 1 Comprehensive RNA Sequencing in Adenoma-Cancer Transition Identified Predictive Biomarkers and Therapeutic Targets of Human CRC. hsa_circ_0049487 hsa_circ_CNN1 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "Receiver operating characteristic (ROC) curve analysis identified three circRNAs (hsa_circ_0049487, hsa_circ_0066875, and hsa_circ_0007444) as possible novel biomarkers predicting the transition from colonic adenoma to cancer. Overall, our findings may provide novel perspectives to clarify the mechanisms of the transition from premalignant adenoma to cancer and identify specific circRNA-related signatures with possible applications for the early diagnosis of and as potential therapeutic targets in CRC." 1 Comprehensive RNA Sequencing in Adenoma-Cancer Transition Identified Predictive Biomarkers and Therapeutic Targets of Human CRC. hsa_circ_0066875 hsa_circ_TIMMDC1 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "Receiver operating characteristic (ROC) curve analysis identified three circRNAs (hsa_circ_0049487, hsa_circ_0066875, and hsa_circ_0007445) as possible novel biomarkers predicting the transition from colonic adenoma to cancer. Overall, our findings may provide novel perspectives to clarify the mechanisms of the transition from premalignant adenoma to cancer and identify specific circRNA-related signatures with possible applications for the early diagnosis of and as potential therapeutic targets in CRC." 1 Comprehensive RNA Sequencing in Adenoma-Cancer Transition Identified Predictive Biomarkers and Therapeutic Targets of Human CRC. hsa_circ_0007444 hsa_circ_RHOBTB3 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "Receiver operating characteristic (ROC) curve analysis identified three circRNAs (hsa_circ_0049487, hsa_circ_0066875, and hsa_circ_0007446) as possible novel biomarkers predicting the transition from colonic adenoma to cancer. Overall, our findings may provide novel perspectives to clarify the mechanisms of the transition from premalignant adenoma to cancer and identify specific circRNA-related signatures with possible applications for the early diagnosis of and as potential therapeutic targets in CRC." 3 "Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis." hsa_circ_0002532 hsa_circ_TCONS_00017187 hsa_circRNA_002532 DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, microarray" down-regulated "the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470." 1 "Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis." hsa_circ_0059665 hsa_circ_ABHD12 has_circRNA_059665 DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, microarray" down-regulated "the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103471." 1 "Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis." hsa_circ_0001626 hsa_circ_BACH2 hsa_circRNA_104156 DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, microarray" down-regulated "the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103472." 1 "Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis." hsa_circ_0000378 hsa_circ_LRP6 hsa_circRNA_101015 DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, microarray" up-regulated "the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103473." 1 "Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis." hsa_circ_0029407 hsa_circ_GLT1D1 hsa_circRNA_101211 DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, microarray" up-regulated "the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103474." 1 "Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis." hsa_circ_0067301 hsa_circ_PLXND1 hsa_circRNA_103470 DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, microarray" up-regulated "the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103475." 1 Circular RNA has_circ_0003204 inhibits oxLDL-induced vascular endothelial cell proliferation and angiogenesis. hsa_circ_0003204 hsa_circ_USP36 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Circular RNA has_circ_0003204 inhibits oxLDL-induced vascular endothelial cell proliferation and angiogenesis. 7 CircCBFB-mediated miR-28-5p facilitates abdominal aortic aneurysm via LYPD3 and GRIA4. - hsa_circ_CBFB - DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm RT-qPCR up-regulated "MiR-28-5p acted as an apoptosis driver while circCBFB, GRIA4 and LYPD3 exerted anti-apoptosis effects in VSMCs. Mechanically, GRIA4 and LYPD3 were suppressed by miR-28-5p. Moreover, circCBFB served as a sponge of miR-28-5p, releasing GRIA4 and LYPD3 from miR-28-5p suppression. Functionally, GRIA4, LYPD3 and miR-28-5p were required in circCBFB-mediated VSMC apoptosis. SIGNIFICANCE: This work unveiled an innovative axis of circCBFB/miR-28-5p/GRIA4/LYPD3 in VSMC apoptosis, exerting its potential in providing new thoughts in AAA management." 1 STAT3-induced upregulation of circCCDC66 facilitates the progression of non-small cell lung cancer by targeting miR-33a-5p/KPNA4 axis. - hsa_circ_CCDC66 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "STAT3-induced circCCDC66 upregulation accelerates NSCLC progression via miR-33a-5p/KPNA4 axis, suggesting circCCDC66 as a promising biomarker in NSCLC treatment." 1 Lcn2-derived Circular RNA (hsa_circ_0088732) Inhibits Cell Apoptosis and Promotes EMT in Glioma via the miR-661/RAB3D Axis. hsa_circ_0088732 hsa_circ_LCN2 - DOID:0060108 brain glioma glioma "RT-qPCR, microarray" up-regulated "We demonstrated that hsa_circ_0088732 facilitated glioma progression by sponging miR-661 to increase RAB3D expression. This study provides a theoretical basis for understanding the development and occurrence of glioma, as well as for the development of targeted drugs." 1 A Dual-Circular RNA Signature as a Non-invasive Diagnostic Biomarker for Gastric Cancer. hsa_circ_0021087 hsa_circ_LMO1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated The results indicated that both hsa_circ_0021087 and hsa_circ_0005051 were downregulated in GC. 3 A Dual-Circular RNA Signature as a Non-invasive Diagnostic Biomarker for Gastric Cancer. hsa_circ_0005051 hsa_circ_UBXN7 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated The results indicated that both hsa_circ_0021087 and hsa_circ_0005052 were downregulated in GC. 1 CircRNA hsa_circ_0013958 may contribute to the development of ovarian cancer by affecting epithelial-mesenchymal transition and apoptotic signaling pathways. hsa_circ_0013958 hsa_circ_ACP6 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated Hsa_circ_0013958 may contribute to the development of ovarian cancer by affecting epithelial-mesenchymal transition and apoptotic signaling pathways. 2 Hsa_circ_RNA_0011780 Represses the Proliferation and Metastasis of Non-Small Cell Lung Cancer by Decreasing FBXW7 via Targeting miR-544a. hsa_circ_0011780 hsa_circ_MACF1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated Hsa_circ_RNA_0011780 Represses the Proliferation and Metastasis of Non-Small Cell Lung Cancer by Decreasing FBXW7 via Targeting miR-544a. 2 Hsa_circ_0137008 suppresses the malignant phenotype in colorectal cancer by acting as a microRNA-338-5p sponge. hsa_circ_0137008 hsa_circ_PREX2 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated Hsa_circ_0137008 suppresses the malignant phenotype in colorectal cancer by acting as a microRNA-338-5p sponge. 2 Hsa_Circ_0007843 Acts as a mIR-518c-5p Sponge to Regulate the Migration and Invasion of Colon Cancer SW480 Cells. hsa_circ_0007843 hsa_circ_ARHGAP32 - DOID:219 colon cancer colon cancer "RT-qPCR, microarray" up-regulated "hsa_circ_0007843 acted as an miRNA sponge to regulate MMP2 expression by removing the inhibitory effect of miR-518c-5p on MMP2 gene translation, which further affected the invasive capability of SW480 cells." 1 Hsa_Circ_0007843 Acts as a mIR-518c-5p Sponge to Regulate the Migration and Invasion of Colon Cancer SW480 Cells. hsa_circ_0010575 hsa_circ_HSPG2 - DOID:219 colon cancer colon cancer "RT-qPCR, microarray" up-regulated "By using RT-PCR, we confirmed that the expression of hsa_circ_0007843, hsa_circ_0010575, hsa_circ_0007331, and hsa_circ_0001615 was significantly higher in colon cancer tissue than in normal colonic tissue." 1 Hsa_Circ_0007843 Acts as a mIR-518c-5p Sponge to Regulate the Migration and Invasion of Colon Cancer SW480 Cells. hsa_circ_0007331 hsa_circ_ACAP2 - DOID:219 colon cancer colon cancer "RT-qPCR, microarray" up-regulated "By using RT-PCR, we confirmed that the expression of hsa_circ_0007843, hsa_circ_0010575, hsa_circ_0007331, and hsa_circ_0001616 was significantly higher in colon cancer tissue than in normal colonic tissue." 2 Hsa_Circ_0007843 Acts as a mIR-518c-5p Sponge to Regulate the Migration and Invasion of Colon Cancer SW480 Cells. hsa_circ_0001615 hsa_circ_PHIP - DOID:219 colon cancer colon cancer "RT-qPCR, microarray" up-regulated "By using RT-PCR, we confirmed that the expression of hsa_circ_0007843, hsa_circ_0010575, hsa_circ_0007331, and hsa_circ_0001617 was significantly higher in colon cancer tissue than in normal colonic tissue." 1 Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy. mmu_circ_0000250 - - DOID:10881 "hand, foot and mouth disease" diabetic foot ulcer RT-qPCR down-regulated "mmu_circ_0000250 enhanced the therapeutic effect of ADSC-exosomes to promote wound healing in diabetes by absorption of miR-128-3p and upregulation of SIRT1. Therefore, these findings advocate targeting the mmu_circ_0000250/miR-128-3p/SIRT1 axis as a candidate therapeutic option for diabetic ulcers." 1 Circular RNA YAP1 acts as the sponge of microRNA-21-5p to secure HK-2 cells from ischaemia/reperfusion-induced injury. hsa_circ_0024093 hsa_circ_YAP1 - DOID:3021 acute kidney failure acute kidney injury RT-qPCR down-regulated circYAP1 activated PI3K/AKT/mTOR pathway and secured HK-2 cells from I/R injury via sponging miR-21-5p. 1 Circular RNA circ_0001105 Inhibits Progression and Metastasis of Osteosarcoma by Sponging miR-766 and Activating YTHDF2 Expression. hsa_circ_0001105 hsa_circ_SP140 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "Our findings suggest that circ_0001105 inhibits OS progression, at least partially, by regulating miR-766/YTHDF2 signaling pathway." 1 CircMACF1 Attenuates Acute Myocardial Infarction Through miR-500b-5p-EMP1 Axis. - mmu_circ_MACF1 - DOID:9408 acute myocardial infarction acute myocardial Infarction "RT-qPCR, RNA-seq" down-regulated CircMACF1 impaired the progression of AMI by modulating the miR-500b-5p/EMP1 axis. CircMACF1 may be a potential therapeutic target for treating AMI. Graphical Abstract CircMACF1 upregulated EMP1 expression by sponge miR-500b-5p. 1 CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification. hsa_circ_0000384 hsa_circ_MRPS35 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated "Our findings not only reveal the pivotal roles of circMRPS35 in governing histone modification in anticancer treatment, but also advocate for triggering circMRPS35/KAT7/FOXO1/3a pathway to combat gastric cancer." 2 "Circ_0032821 acts as an oncogene in cell proliferation, metastasis and autophagy in human gastric cancer cells in vitro and in vivo through activating MEK1/ERK1/2 signaling pathway." hsa_circ_0032821 hsa_circ_CEP128 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Circ_0032821 expression induced cell proliferation, EMT, migration, invasion, and autophagy inhibition in human GC cells in vitro and in vivo through activating MEK1/ERK1/2 signaling pathway, suggesting circ_0032821 as an oncogenic role in GC." 3 "Effect of up-regulation of circMATR3 on the proliferation, metastasis, progression and survival of hypopharyngeal carcinoma." - hsa_circ_MATR3 - DOID:8533 hypopharynx cancer hypopharyngeal cancer "RT-qPCR, RNA-seq" up-regulated "circMATR3 may participate in cancer-related pathways by serving as miRNA sponges. In conclusion, our findings first identified the oncogenic roles of circMATR3 in promoting the progression of HSCC and demonstrated that circMATR3 may be a novel prognostic marker and therapeutic target for HSCC." 1 Circ-PGAM1 promotes malignant progression of epithelial ovarian cancer through regulation of the miR-542-3p/CDC5L/PEAK1 pathway. - hsa_circ_PGAM1 - DOID:2152 ovary epithelial cancer epithelial ovarian cancer RT-qPCR up-regulated The circ-PGAM1/miR-542-3p/CDC5L/PEAK1 pathway played an important role in the progression of ovarian cancer and might be a novel therapeutic target for ovarian cancer. 1 "A novel circular RNA, circ-ATAD1, contributes to gastric cancer cell progression by targeting miR-140-3p/YY1/PCIF1 signaling axis." - hsa_circ_ATAD1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated "A novel circular RNA, circ-ATAD1, contributes to gastric cancer cell progression by targeting miR-140-3p/YY1/PCIF1 signaling axis." 1 CircPIP5K1A activates KRT80 and PI3K/AKT pathway to promote gastric cancer development through sponging miR-671-5p. - hsa_circ_PIP5K1A - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "CircPIP5K1A/miR-671-5p/KRT80 axis contributes to GC progression through PI3K/AKT pathway, implying this axis may be a potential therapeutic target for the treatment of GC patients." 2 CircAKT3 inhibits glycolysis balance in lung cancer cells by regulating miR-516b-5p/STAT3 to inhibit cisplatin sensitivity. - hsa_circ_AKT3 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "CircAKT3 inhibit cisplatin sensitivity of lung cancer cells at least partly through regulating miR-516b-5p/STAT3 axis-mediated glycolysis balance, providing a possible long noncoding RNA -targeted therapy for lung cancer." 1 Circular RNA expression profile in blood according to ischemic stroke etiology. - - hsa_circRNA_102488 DOID:6713 cerebrovascular disease stroke "RT-qPCR, microarray" down-regulated "Differential expression of hsa_circRNA_102488, originated from UBA52 gene, was replicated in the validation cohort." 1 A two-circular RNA signature of donor circFOXN2 and circNECTIN3 predicts early allograft dysfunction after liver transplantation. - hsa_circ_FOXN2 - DOID:409 liver disease early allograft dysfunction after liver transplantation "RT-qPCR, RNA-seq" down-regulated Donor circFOXN2 and circNEXTIN3 were associated with the incidence of EAD. The novel model combing the two-circular RNA signature had a high predictive value for EAD. 1 A two-circular RNA signature of donor circFOXN2 and circNECTIN3 predicts early allograft dysfunction after liver transplantation. - hsa_circ_NECTIN3 - DOID:409 liver disease early allograft dysfunction after liver transplantation "RT-qPCR, RNA-seq" down-regulated Donor circFOXN2 and circNEXTIN4 were associated with the incidence of EAD. The novel model combing the two-circular RNA signature had a high predictive value for EAD. 1 CircRNA_0058063 functions as a ceRNA in bladder cancer progression via targeting miR-486-3p/FOXP4 axis. hsa_circ_0058063 hsa_circ_ATIC - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "circRNA_0058063 functions by sponging miR-486-3p in BC progression, which could act as a new biomarker and further developed to be a therapeutic target in BC." 3 Circ_0038467 regulates lipopolysaccharide-induced inflammatory injury in human bronchial epithelial cells through sponging miR-338-3p. hsa_circ_0038467 hsa_circ_UQCRC2 - DOID:552 pneumonia pneumonia RT-qPCR up-regulated "The current work had led to the identification of circ_0038467 knockdown that alleviated LPS-induced inflammatory injury in 16HBE cells at least partly through sponging miR-338-3p and regulating JAK/STAT3 pathway, highlighting novel molecular targets for the treatment of pneumonia." 4 "Circ-FOXM1 contributes to cell proliferation, invasion, and glycolysis and represses apoptosis in melanoma by regulating miR-143-3p/FLOT2 axis." - hsa_circ_FOXM1 - DOID:1909 melanoma melanoma RT-qPCR up-regulated Circ-FOXM1 facilitated the development of melanoma by upregulating FLOT2 through miR-143-3p. 2 Hsa_circ_103973 Acts as a Sponge of miR-335 to Promote Cervical Cancer Progression. - - hsa_circ_103973 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Circ_103973 promoted CC cell proliferation in vitro by physically binding miR-335, which further targeted and regulated PPP6C." 1 Circular RNA hsa_circ_0068033 Acts as a Diagnostic Biomarker and Suppresses the Progression of Breast Cancer Through Sponging miR-659. hsa_circ_0068033 hsa_circ_NAALADL2 - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "hsa_circ_0068033 acts as a tumor suppressor gene in BC, and the hsa_circ_0068033/miR-659 axis participates in the progression of BC." 2 Hsa_circ_0012563 promotes migration and invasion of esophageal squamous cell carcinoma by regulating XRCC1/EMT pathway. hsa_circ_0012563 hsa_circ_ZYG11A - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated Hsa_circ_0012563 promotes migration and invasion of esophageal squamous cell carcinoma by regulating XRCC1/EMT pathway. 1 "Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer." - hsa_circ_LARP4 - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer." 2 Circular RNA hsa_circ_0004812 impairs IFN-induced immune response by sponging miR-1287-5p to regulate FSTL1 in chronic hepatitis B. hsa_circ_0004812 hsa_circ_NINL - DOID:2043 hepatitis B chronic hepatitis b RT-qPCR up-regulated Circ_0004812 was identified as a potential target for CHB infection. Circ_0004812 promoted the expression of FSTL1 by inhibiting miR-1287-5p. 1 CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17. - hsa_circ_LONP2 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq, microarray" up-regulated "circLONP2 acts as key metastasis-initiating molecule during CRC progression through modulating the intracellular maturation and intercellular transfer of miR-17, resulting in dissemination of metastasis-initiating ability in primary site and acceleration of metastasis formation in foreign organs. circLONP2 could serve as an effective prognostic predictor and/or novel anti-metastasis therapeutic target in CRC treatment." 1 Circ_0072083 interference enhances growth-inhibiting effects of cisplatin in non-small-cell lung cancer cells via miR-545-3p/CBLL1 axis. hsa_circ_0072083 - circ_0072083 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0072083 interference enhances growth-inhibiting effects of cisplatin in non-small-cell lung cancer cells via miR-545-3p/CBLL1 axis. 1 Circular RNA circPITX1 knockdown inhibits glycolysis to enhance radiosensitivity of glioma cells by miR-329-3p/NEK2 axis. - hsa_circ_PITX1 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "CircPITX1 knockdown reduced glycolysis to contribute to radiosensitivity in glioma through miR-329-3p/NEK2 axis, providing a possible mechanism of circPITX1 in the development of glioma." 2 CircPIP5K1A facilitates gastric cancer progression via miR-376c-3p/ZNF146 axis. hsa_circ_0014130 hsa_circ_PIP5K1A - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircPIP5K1A facilitates gastric cancer progression via miR-376c-3p/ZNF146 axis. 2 Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axis. hsa_circ_0008035 - circ_0008035 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axis. 4 RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis. hsa_circ_0001200 hsa_circ_PTTG1IP - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "Generally, these results suggest that expression of hsa_circ_0001200, hsa_circ_0001566, hsa_circ_0003972, and hsa_circ_0008360 in PBMCs from RA patients may serve as potential biomarkers for the diagnosis of RA, and these circRNAs may influence the occurrence and development of RA." 1 RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis. hsa_circ_0001566 hsa_circ_MAPK9 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "Generally, these results suggest that expression of hsa_circ_0001200, hsa_circ_0001566, hsa_circ_0003972, and hsa_circ_0008361 in PBMCs from RA patients may serve as potential biomarkers for the diagnosis of RA, and these circRNAs may influence the occurrence and development of RA." 2 RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis. hsa_circ_0003972 hsa_circ_FAM120A - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "Generally, these results suggest that expression of hsa_circ_0001200, hsa_circ_0001566, hsa_circ_0003972, and hsa_circ_0008362 in PBMCs from RA patients may serve as potential biomarkers for the diagnosis of RA, and these circRNAs may influence the occurrence and development of RA." 1 RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis. hsa_circ_0008360 hsa_circ_XPNPEP3 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR down-regulated "Generally, these results suggest that expression of hsa_circ_0001200, hsa_circ_0001566, hsa_circ_0003972, and hsa_circ_0008363 in PBMCs from RA patients may serve as potential biomarkers for the diagnosis of RA, and these circRNAs may influence the occurrence and development of RA." 2 Circ0004390 promotes cell proliferation through sponging miR-198 in ovarian cancer. hsa_circ_0004390 - Circ0004390 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Circ0004390 regulated ovarian cancer proliferation by miR-198/MET axis, which might provide a potential target for the treatment of ovarian cancer." 1 Hsa_circ_0008225 inhibits tumorigenesis of glioma via sponging miR-890 and promoting ZMYND11 expression. hsa_circ_0008225 hsa_circ_ZMYND11 - DOID:0060108 brain glioma glioma RT-qPCR down-regulated "Our results suggested that hsa_circ_0008225 functions as a tumor inhibitor in glioma by sponging miR-890 and then promoting the function of ZMYND11. Therefore, hsa_circ_0008225 could be a potential prognostic biomarker for the treatment of glioma." 1 hsa_circ_001653 Implicates in the Development of Pancreatic Ductal Adenocarcinoma by Regulating MicroRNA-377-Mediated HOXC6 Axis. hsa_circ_0001568 hsa_circ_DUSP22 - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated hsa_circ_001653 Implicates in the Development of Pancreatic Ductal Adenocarcinoma by Regulating MicroRNA-377-Mediated HOXC6 Axis. 1 circRNA-AKT1 Sequesters miR-942-5p to Upregulate AKT1 and Promote Cervical Cancer Progression. hsa_circ_0033550 - circ-0033550 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "we illustrated that circ-AKT1 upregulated AKT1 by sponging miR-942-5p. Rescue assays confirmed the role of the circ-AKT1/miR-942-5p/AKT1 axis in CC progression. In vivo assays validated that circ-AKT1 promoted tumor growth in CC. Overall, circRNA-AKT1 sequestered miR-942-5p to upregulate AKT1 and promote CC progression, which may offer a new molecular target for the treatment improvement of CC." 1 Circular RNA expression profiling in the fetal side of placenta from maternal polycystic ovary syndrome and circ_0023942 inhibits the proliferation of human ovarian granulosa cell. hsa_circ_0023942 - circ_0023942 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, microarray" down-regulated Maternal PCOS impairs circ_0023942 expression in fetus. Overexpression of circ_0023942 inhibits human ovarian granulosa cell proliferation possibly via regulating CDK-4. 1 Circular RNA MTO1 suppresses tumorigenesis of gastric carcinoma by sponging miR-3200-5p and targeting PEBP1. - hsa_circ_MTO1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Circular RNA MTO1 suppresses tumorigenesis of gastric carcinoma by sponging miR-3200-5p and targeting PEBP1. 3 circGNB1 Facilitates Triple-Negative Breast Cancer Progression by Regulating miR-141-5p-IGF1R Axis. - hsa_circ_GNB1 - DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated circGNB1 Facilitates Triple-Negative Breast Cancer Progression by Regulating miR-141-5p-IGF1R Axis. 1 Circular RNA CircHIPK3 Promotes Gemcitabine Sensitivity in Bladder Cancer. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "The circHIPK3 is low-expressed in BC and is an independent prognostic biomarker for BC patients. The low-expression of circHIPK3 is associated with the insensitivity to gemcitabine of BC patients, over-expression of circHIPK3 promotes gemcitabine sensitivity in BC." 4 Circular RNA-ABCB10 suppresses hepatocellular carcinoma progression through upregulating NRP1/ABL2 via sponging miR-340-5p/miR-452-5p. hsa_circ_0008717 hsa_circ_ABCB10 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated Circular RNA-ABCB10 suppresses hepatocellular carcinoma progression through upregulating NRP1/ABL2 via sponging miR-340-5p/miR-452-5p. 2 "Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis." - hsa_circ_DENND4C - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis." 1 Circ_0001971 regulates oral squamous cell carcinoma progression and chemosensitivity by targeting miR-194/miR-204 in vitro and in vivo. hsa_circ_0001971 - circ_0001971 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Circ_0001971 regulates cell proliferation, migration, invasion, apoptosis, and chemosensitivity of OSCC by interacting with miR-194 and miR-204 in vitro and in vivo. We provided a theoretical basis for the action mechanism of circ_0001971 on OSCC progression and chemosensitivity." 3 Circular RNA circ-ABCB10 promotes non-small cell lung cancer proliferation and inhibits cell apoptosis through repressing KISS1. hsa_circ_0008717 hsa_circ_ABCB10 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Results above indicated that circ-ABCB10 promoted cell proliferation and inhibited cell apoptosis of NSCLC by suppressing KISS1, which suggested that circ-ABCB10 may be a potential therapeutic target in NSCLC." 4 Circular RNA circ_0103552 promotes the invasion and migration of thyroid carcinoma cells by sponging miR-127. - - circ-0103552 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated circ-0103552 acts as a regulator in the invasion and migration of TC by sponging miR-127. 1 "Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma." - hsa_circ_TTBK2 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Circ-TTBK2 regulated cell proliferation, invasion and ferroptosis via targeting ITGB8 by sponging miR-761 in glioma, providing a promising biomarker for the clinical therapy of human glioma." 4 mmu_circ_0000790 Is Involved in Pulmonary Vascular Remodeling in Mice with HPH via MicroRNA-374c-Mediated FOXC1. mmu_circ_0000790 - mmu_circ_0000790 DOID:6432 pulmonary hypertension pulmonary hypertension RT-qPCR up-regulated mmu_circ_0000790 Is Involved in Pulmonary Vascular Remodeling in Mice with HPH via MicroRNA-374c-Mediated FOXC1. 1 circ_0000638 inhibits neodymium oxide-induced bronchial epithelial cell inflammation through the miR-498-5p/NF-kappaB axis. - - circRNA_0000638 DOID:1176 bronchial disease neodymium oxide-induced bronchial epithelial cell inflammation RT-qPCR down-regulated "Circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells." 1 Circular RNA circMTO1 Suppresses RCC Cancer Cell Progression via miR9/LMX1A Axis. - hsa_circ_MTO1 - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated "circMTO1 suppresses renal cell carcinoma progression by circMTO1/miR9/ LMX1A, indicating that circMTO1 may be a potential target in renal cell carcinoma therapy." 1 "A novel circular RNA (hsa_circRNA_102336), a plausible biomarker, promotes the tumorigenesis by sponging miR-515-5p in human bladder cancer." - - hsa_circRNA_102336 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated circ_102336 indirectly regulate apoptosis and ABC transport pathways through miR-515-5p to finally modulate BC cell proliferation and chemo-resistance. 1 CircEHMT1 inhibits metastatic potential of breast cancer cells by modulating miR-1233-3p/KLF4/MMP2 axis. - hsa_circ_EHMT1 - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated circEHMT1 has potential as a prognostic factor in breast cancer and played a tumor suppressor role via the circEHMT1/miR-1233-3p/KLF4/MMP2 axis. 1 Up-Regulation of Hsa_circ_0008792 Inhibits Osteosarcoma Cell Invasion and Migration and Promotes Apoptosis by Regulating Hsa-miR-711/ZFP1. hsa_circ_0008792 hsa_circ_PAPPA - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated Up-Regulation of Hsa_circ_0008792 Inhibits Osteosarcoma Cell Invasion and Migration and Promotes Apoptosis by Regulating Hsa-miR-711/ZFP1. 5 hsa_circRNA_012515 Is Highly Expressed in NSCLC Patients and Affects Its Prognosis. hsa_circ_0001255 hsa_circ_PANX2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated hsa_circRNA_012515 Is Highly Expressed in NSCLC Patients and Affects Its Prognosis. 1 Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs. hsa_circ_0097435 - - DOID:114 heart disease heart failure "RT-qPCR, RNA-seq" up-regulated hsa_circ_0097435 can be used as a biological blood marker and revealed a new pathway involved in regulating myocardial cell injury. 1 Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs. hsa_circ_0099476 hsa_circ_WNK1 - DOID:114 heart disease heart failure "RT-qPCR, RNA-seq" up-regulated "The levels of hsa_circ_0097435 (p < 0.01), hsa_circ_0099476 (p < 0.01), hsa_circ_0001312 (p < 0.01), hsa_circ_0005158 (p < 0.01), hsa_circ_0029696 (p < 0.01), and hsa_circ_0040414 (p < 0.01) were significantly higher in the HF group than in the NC group." 1 Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs. hsa_circ_0001312 hsa_circ_CCDC66 - DOID:114 heart disease heart failure "RT-qPCR, RNA-seq" up-regulated "The levels of hsa_circ_0097435 (p < 0.01), hsa_circ_0099476 (p < 0.01), hsa_circ_0001312 (p < 0.01), hsa_circ_0005158 (p < 0.01), hsa_circ_0029696 (p < 0.01), and hsa_circ_0040414 (p < 0.01) were significantly higher in the HF group than in the NC group." 1 Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs. hsa_circ_0005158 hsa_circ_RALBP1 - DOID:114 heart disease heart failure "RT-qPCR, RNA-seq" up-regulated "The levels of hsa_circ_0097435 (p < 0.01), hsa_circ_0099476 (p < 0.01), hsa_circ_0001312 (p < 0.01), hsa_circ_0005158 (p < 0.01), hsa_circ_0029696 (p < 0.01), and hsa_circ_0040414 (p < 0.01) were significantly higher in the HF group than in the NC group." 1 Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs. hsa_circ_0029696 hsa_circ_SKA3 - DOID:114 heart disease heart failure "RT-qPCR, RNA-seq" up-regulated "The levels of hsa_circ_0097435 (p < 0.01), hsa_circ_0099476 (p < 0.01), hsa_circ_0001312 (p < 0.01), hsa_circ_0005158 (p < 0.01), hsa_circ_0029696 (p < 0.01), and hsa_circ_0040414 (p < 0.01) were significantly higher in the HF group than in the NC group." 1 Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs. hsa_circ_0040414 hsa_circ_TXNL4B - DOID:114 heart disease heart failure "RT-qPCR, RNA-seq" up-regulated "The levels of hsa_circ_0097435 (p < 0.01), hsa_circ_0099476 (p < 0.01), hsa_circ_0001312 (p < 0.01), hsa_circ_0005158 (p < 0.01), hsa_circ_0029696 (p < 0.01), and hsa_circ_0040414 (p < 0.01) were significantly higher in the HF group than in the NC group." 2 Hsa_circ_0001649 restrains gastric carcinoma growth and metastasis by downregulation of miR-20a. hsa_circ_0001649 hsa_circ_SHPRH - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Upregulation of hsa_circ_0001649 restrained GC cell growth and metastasis by downregulating miR-20a and thereby inactivated ERK and Wnt/beta-catenin pathways. 2 Circular RNA profile in diabetic peripheral neuropathy: analysis of coexpression networks of circular RNAs and mRNAs. mmu_circ_0000904 - - DOID:9743 diabetic neuropathy diabetic neuropathy "RT-qPCR, microarray" up-regulated The results also showed that the expression of circRNA.4614 was upregulated significantly. 1 Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression. - hsa_circ_CDYL - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circCDYL promotes BC progression via the miR-1275-ATG7/ULK1-autophagic axis and circCDYL could act as a potential prognostic and predictive molecule for breast cancer patients. 2 CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA-Binding Proteins and Sponging MiR-942. - hsa_circ_FOXK2 - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated "circFOXK2 promoted cell growth, migration, and invasion and was involved in cell-cycle progression and apoptosis. circFOXK2 contained multiple miRNA binding sites, functioning as a sponge for miR-942, which in turn promoted expression of ANK1, GDNF, and PAX6. " 1 Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer. - - hsa_circ_100242 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "The results from RT-qPCR demonstrated that hsa_circ_100241, hsa_circ_100242 and hsa_circ_101303 were markedly upregulated whereas hsa_circ_104510 was significantly downregulated in bladder cancer tissues compared with normal tissue." 1 Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer. - - hsa_circ_100241 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "The results from RT-qPCR demonstrated that hsa_circ_100241, hsa_circ_100242 and hsa_circ_101303 were markedly upregulated whereas hsa_circ_104510 was significantly downregulated in bladder cancer tissues compared with normal tissue." 1 Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer. - - hsa_circ_101303 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "The results from RT-qPCR demonstrated that hsa_circ_100241, hsa_circ_100242 and hsa_circ_101303 were markedly upregulated whereas hsa_circ_104510 was significantly downregulated in bladder cancer tissues compared with normal tissue." 1 Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer. - - hsa_circ_104510 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" down-regulated "The results from RT-qPCR demonstrated that hsa_circ_100241, hsa_circ_100242 and hsa_circ_101303 were markedly upregulated whereas hsa_circ_104510 was significantly downregulated in bladder cancer tissues compared with normal tissue." 1 Integrated analysis of transcriptome profiling predicts potential lncRNA and circRNA targets in human nasopharyngeal carcinoma. - - hsa_circRNA_104204 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, microarray" up-regulated "The changes in expression of the four selected DE circRNAs (hsa_circRNA_104204, hsa_circRNA_101252, hsa_circRNA_100160 and hsa_circRNA_001430) were consistent with the results of microarray analysis." 1 Integrated analysis of transcriptome profiling predicts potential lncRNA and circRNA targets in human nasopharyngeal carcinoma. - - hsa_circRNA_101252 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, microarray" up-regulated "The changes in expression of the four selected DE circRNAs (hsa_circRNA_104204, hsa_circRNA_101252, hsa_circRNA_100160 and hsa_circRNA_001430) were consistent with the results of microarray analysis." 1 Integrated analysis of transcriptome profiling predicts potential lncRNA and circRNA targets in human nasopharyngeal carcinoma. - - hsa_circRNA_100160 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, microarray" up-regulated "The changes in expression of the four selected DE circRNAs (hsa_circRNA_104204, hsa_circRNA_101252, hsa_circRNA_100160 and hsa_circRNA_001430) were consistent with the results of microarray analysis." 1 Integrated analysis of transcriptome profiling predicts potential lncRNA and circRNA targets in human nasopharyngeal carcinoma. - - hsa_circRNA_001430 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, microarray" down-regulated "The changes in expression of the four selected DE circRNAs (hsa_circRNA_104204, hsa_circRNA_101252, hsa_circRNA_100160 and hsa_circRNA_001430) were consistent with the results of microarray analysis." 1 Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR-605/FOXO3/ABCB1 axis. - hsa_circ_FBXO11 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR-605/FOXO3/ABCB1 axis. 1 Hsa_circ_0061140 promotes endometrial carcinoma progression via regulating miR-149-5p/STAT3. hsa_circ_0061140 hsa_circ_C20orf11 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated hsa_circ_0061140 might act as an effective therapy to treat EC through functioning as a molecular sponge of miR-149-5p. 1 CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p. - mmu_circ_ZFP644 - DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, RNA-seq" down-regulated CircZFP644 may play an important role in the pathogenesis of SAP through sponging miR-21-3p. Our findings may provide novel insights regarding the workings of the pathophysiological mechanism of SAP and offer novel targets for SAP. 1 CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p. - mmu_circ_AMY2a5 - DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, RNA-seq" down-regulated "The expression levels of CircAMY2a5, CircZFP644, CircDTNB, CircCELA3b, CircARHGEF38, and CircSRPK2, were significantly downregulated in the SAP group compared with the normal control. Taken together, the qRT-PCR results for these six circRNAs were consistent with the RNA-seq data." 1 CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p. - mmu_circ_DTNB - DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, RNA-seq" down-regulated "The expression levels of CircAMY2a5, CircZFP644, CircDTNB, CircCELA3b, CircARHGEF38, and CircSRPK2, were significantly downregulated in the SAP group compared with the normal control. Taken together, the qRT-PCR results for these six circRNAs were consistent with the RNA-seq data." 1 CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p. - mmu_circ_CELA3b - DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, RNA-seq" down-regulated "The expression levels of CircAMY2a5, CircZFP644, CircDTNB, CircCELA3b, CircARHGEF38, and CircSRPK2, were significantly downregulated in the SAP group compared with the normal control. Taken together, the qRT-PCR results for these six circRNAs were consistent with the RNA-seq data." 1 CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p. - mmu_circ_ARHGEF38 - DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, RNA-seq" down-regulated "The expression levels of CircAMY2a5, CircZFP644, CircDTNB, CircCELA3b, CircARHGEF38, and CircSRPK2, were significantly downregulated in the SAP group compared with the normal control. Taken together, the qRT-PCR results for these six circRNAs were consistent with the RNA-seq data." 1 CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p. - mmu_circ_SRPK2 - DOID:2913 acute pancreatitis acute pancreatitis "RT-qPCR, RNA-seq" down-regulated "The expression levels of CircAMY2a5, CircZFP644, CircDTNB, CircCELA3b, CircARHGEF38, and CircSRPK2, were significantly downregulated in the SAP group compared with the normal control. Taken together, the qRT-PCR results for these six circRNAs were consistent with the RNA-seq data." 1 Cisplatin resistance-associated circRNA_101237 serves as a prognostic biomarker in hepatocellular carcinoma. - - circRNA_101237 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "CircRNA_101237 was determined to be upregulated in tumor tissue and serum of patients with HCC as compared with that in paracancerous tissues and the serum of healthy controls, respectively. In addition, the expression of circRNA_101237 was associated with tumor size, lymph node metastasis, distant metastasis and TNM stage." 1 Circular RNA CCDC66 promotes gastric cancer progression by regulating c-Myc and TGF-beta signaling pathways. - hsa_circ_CCDC66 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "CircCCDC66 promotes GC growth and metastasis by activating c-Myc and TGF-beta signaling pathways, suggesting that it may serve as a potential biomarker for GC." 2 Global transcriptomic study of circRNAs expression profile in sorafenib resistant hepatocellular carcinoma cells. hsa_circ_0006294 hsa_circ_CRIM1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated "our data demonstrate, using a global transcriptomic network, that the circRNA expression profile is significantly altered in sorafenib-resistant HCC cells and that the differentially expressed circRNAs may play important functions in HCC sorafenib resistance and HCC progression." 2 Global transcriptomic study of circRNAs expression profile in sorafenib resistant hepatocellular carcinoma cells. hsa_circ_0035944 hsa_circ_DENND4A - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated "our data demonstrate, using a global transcriptomic network, that the circRNA expression profile is significantly altered in sorafenib-resistant HCC cells and that the differentially expressed circRNAs may play important functions in HCC sorafenib resistance and HCC progression." 1 Global transcriptomic study of circRNAs expression profile in sorafenib resistant hepatocellular carcinoma cells. hsa_circ_0084663 hsa_circ_CSPP1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated "our data demonstrate, using a global transcriptomic network, that the circRNA expression profile is significantly altered in sorafenib-resistant HCC cells and that the differentially expressed circRNAs may play important functions in HCC sorafenib resistance and HCC progression." 6 circFOXM1 promotes proliferation of non-small cell lung carcinoma cells by acting as a ceRNA to upregulate FAM83D. hsa_circ_0025039 hsa_circ_FOXM1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" up-regulated "circFOXM1promotes NSCLC progression by interacting with miR-614 and thus inactivating the function of miR-614, which will further release the suppression of FAM83D. circFOXM1/miR-614/FAM83D regulatory network may serve as a potential therapeutic target for NSCLC patients." 4 The Circular RNA circSKA3 Binds Integrin beta1 to Induce Invadopodium Formation Enhancing Breast Cancer Invasion. hsa_circ_0000467 hsa_circ_SKA3 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "the circular RNA circSKA3 promotes tumor progression by complexing with Tks5 and integrin beta1, inducing invadopodium formation." 2 Circular RNA MAN2B2 promotes cell proliferation of hepatocellular carcinoma cells via the miRNA-217/MAPK1 axis. - hsa_circ_MAN2B2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circMAN2B2 acted as an onco-miRNA in HCC by sponging miRNA-217 to promote MAPK1 expression. 1 miR-488-3p sponged by circ-0000495 and mediated upregulation of TROP2 in head and neck squamous cell carcinoma development. hsa_circ_0000495 hsa_circ_MYCBP2 - DOID:5520 head and neck squamous cell carcinoma head and neck squamous cell carcinoma RT-qPCR up-regulated "Our study unraveled a novel mechanism by which down-regulation of miR-488-3p sponged by circ-0000495 releases its epigenetic silencing to TROP2. The increased TROP2 promotes tumor proliferation, therefore, providing evidence in support of targeting the circ-0000495/miR-488-3p/TROP2 axis in contributing to HNSCC therapy and preventing tumor metastasis." 1 "Circular RNA circ_ACACA regulates proliferation, migration and glycolysis in non_small_cell lung carcinoma via miR_1183 and PI3K/PKB pathway." - hsa_circ_ACACA circ-ACACA DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ_ACACA regulated the PI3K/PKB pathway through interacting with miR_1183 and downregulation of circ_ACACA suppressed tumor growth. 3 EMT related circular RNA expression profiles identify circSCYL2 as a novel molecule in breast tumor metastasis. - hsa_circ_SCYL2 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated "The current study identified that circSCYL2 was downregulated in breast cancer tissues and cell lines, and that circSCYL2 overexpression inhibited cell migration and invasion. This study provides expression profiles of circRNAs in EMT groups of breast cancer cells. circSCYL2, which is downregulated in breast cancer tissues and cells, may play an important role in breast cancer EMT progression." 1 circ_ARF3 regulates the pathogenesis of osteosarcoma by sponging miR-1299 to maintain CDK6 expression. - hsa_circ_ARF3 circ_ARF3 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "in the OS, highly expressed circ_ARF3 acts as a sponge of miR-1299 to inhibit miR-1299 mediated CDK6 downregulation which further promoted OS pathogenesis. circ_ARF3 could be a potential target for OS treatment in the future." 1 Circ_0001178 regulates miR-382/VEGFA axis to facilitate hepatocellular carcinoma progression. hsa_circ_0001178 - circ_0001178 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0001178 was demonstrated to modulate miR-382 expression negatively. The effect of circ_0001178 on HCC tumor was rescued by miR-382 overexpression. Furthermore, vascular epithelial growth factor A (VEGFA) is identified in various cancers. Currently, VEGFA was proved to be the downstream target of miR-382." 1 A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating Snail in colon cancer. - hsa_circ_FNDC3B - DOID:219 colon cancer colon cancer "RT-qPCR, RNA-seq" down-regulated "circFNDC3B-218aa inhibited the expression of Snail, and subsequently promoted the tumor-suppressive effect of FBP1 in CC." 1 "The regulatory network among CircHIPK3, LncGAS5, and miR-495 promotes Th2 differentiation in allergic rhinitis." hsa_circ_0000284 hsa_circ_HIPK3 - DOID:4481 allergic rhinitis allergic rhinitis RT-qPCR up-regulated The results showed that the highly expressed CircHIPK3 and LncGAS5 promoted Th2 differentiation of ovalbumin-induced CD4(+) T cells and aggravated nasal symptoms of AR mice. We also found that CircHIPK3 and LncGAS5 induced the upregulation of Th2 cell-specific transcript factor GATA-3 via modulating their common target miR-495. 1 Hsa_circ_0079662 induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF-alpha pathway in human colon cancer. hsa_circ_0079662 hsa_circ_HOXA9 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "hsa_circ_0079662, as a ceRNA binding with hsa-mir-324-5p, can regulate target gene HOXA9 and induced the mechanism of chemotherapy drug oxaliplatin resistance in CRC through the TNF-alpha pathway in human colon cancer." 1 Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage. hsa_circ_0001868 hsa_circ_AGTPBP1 - DOID:936 brain disease periventricular white matter damage "RT-qPCR, RNA-seq" up-regulated "Up-regulated circRNAs including hsa_circ_0001868, hsa_circ_0083176, hsa_circ_0018401, and hsa_circ_0006357 and down-regulated circRNA hsa_circ_0006716 were confirmed by results from qPCR." 1 Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage. hsa_circ_0083176 hsa_circ_DNAJB6 - DOID:936 brain disease periventricular white matter damage "RT-qPCR, RNA-seq" up-regulated "Up-regulated circRNAs including hsa_circ_0001868, hsa_circ_0083176, hsa_circ_0018401, and hsa_circ_0006357 and down-regulated circRNA hsa_circ_0006716 were confirmed by results from qPCR." 1 Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage. hsa_circ_0018401 hsa_circ_SGMS1 - DOID:936 brain disease periventricular white matter damage "RT-qPCR, RNA-seq" up-regulated "Up-regulated circRNAs including hsa_circ_0001868, hsa_circ_0083176, hsa_circ_0018401, and hsa_circ_0006357 and down-regulated circRNA hsa_circ_0006716 were confirmed by results from qPCR." 1 Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage. hsa_circ_0006357 hsa_circ_EZH2 - DOID:936 brain disease periventricular white matter damage "RT-qPCR, RNA-seq" up-regulated "Up-regulated circRNAs including hsa_circ_0001868, hsa_circ_0083176, hsa_circ_0018401, and hsa_circ_0006357 and down-regulated circRNA hsa_circ_0006716 were confirmed by results from qPCR." 1 Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage. hsa_circ_0006716 hsa_circ_UBE2D2 - DOID:936 brain disease periventricular white matter damage "RT-qPCR, RNA-seq" down-regulated "Up-regulated circRNAs including hsa_circ_0001868, hsa_circ_0083176, hsa_circ_0018401, and hsa_circ_0006357 and down-regulated circRNA hsa_circ_0006716 were confirmed by results from qPCR." 1 A circRNA derived from linear HIPK3 relieves the neuronal cell apoptosis in spinal cord injury via ceRNA pattern. hsa_circ_0000284 rno_circ_HIPK3 - DOID:319 spinal cord disease spinal cord injury RT-qPCR down-regulated circ-HIPK3 relieves the neuronal cell apoptosis through regulating miR-588/DPYSL5 axis in SCI. 1 Circular RNA hsa_circ_0000326 acts as a miR-338-3p sponge to facilitate lung adenocarcinoma progression. hsa_circ_0000326 hsa_circ_TCONS_l2_00004572 - DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" up-regulated "hsa_circ_0000326 acted as a positive regulator of cell proliferation and migration and a negative regulator of apoptosis. Mechanistic studies showed that hsa_circ_0000326 acted as a miR-338-3p sponge and altered the function of miR-338-3p, which in turn upregulated the expression of the downstream target RAB14 and affected the proliferation, migration and apoptosis of lung adenocarcinoma cells." 1 Circular RNA PVT1 promotes metastasis via regulating of miR-526b/FOXC2 signals in OS cells. - hsa_circ_PVT1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circPVT1, functioning as an oncogene, promotes OS cells metastasis via regulation of FOXC2 by acting as a ceRNA of miR-526b. CircPVT1/miR-526b/FOXC2 axis might be a novel target in molecular treatment of OS." 5 "Downregulated hsa_circ_0077837 and hsa_circ_0004826, facilitate bladder cancer progression and predict poor prognosis for bladder cancer patients." hsa_circ_0077837 hsa_circ_EPB41L2 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "hsa_circ_0077837 and hsa_circ_0004826 might act as tumor suppressors in the bladder cancer progression and serve as a potential biomarker for the diagnosis, prognosis, and therapy of bladder cancer." 1 "Downregulated hsa_circ_0077837 and hsa_circ_0004826, facilitate bladder cancer progression and predict poor prognosis for bladder cancer patients." hsa_circ_0004826 hsa_circ_UTRN - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "hsa_circ_0077837 and hsa_circ_0004826 might act as tumor suppressors in the bladder cancer progression and serve as a potential biomarker for the diagnosis, prognosis, and therapy of bladder cancer." 1 Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjogren syndrome. hsa_circ_0129656 hsa_circ_IQGAP2 - DOID:12894 Sjogren syndrome sjogren syndrome "RT-qPCR, RNA-seq" up-regulated "Circ-IQGAP2 and circ-ZC3H6 had significantly upregulated expression in the MSGs of pSS patients, and this elevated expression was confirmed by quantitative real-time PCR of plasma exosome RNA." 1 Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjogren syndrome. hsa_circ_0001062 hsa_circ_ZC3H6 - DOID:12894 Sjogren syndrome sjogren syndrome "RT-qPCR, RNA-seq" up-regulated "Circ-IQGAP2 and circ-ZC3H6 had significantly upregulated expression in the MSGs of pSS patients, and this elevated expression was confirmed by quantitative real-time PCR of plasma exosome RNA." 1 CircRNACCDC66 regulates cisplatin resistance in gastric cancer via the miR-618/BCL2 axis. hsa_circ_0001313 hsa_circ_CCDC66 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircRNACCDC66 regulates cisplatin resistance in gastric cancer via the miR-618/BCL2 axis. 2 hsa_circRNA_101237: A Novel Diagnostic and Prognostic Biomarker and Potential Therapeutic Target for Multiple Myeloma. - - hsa_circRNA_101237 DOID:9538 multiple myeloma multiple myeloma "RT-qPCR, microarray" up-regulated "It was first reported that hsa_circRNA_101237 was significantly upregulated in MM. It was indicated that hsa_circRNA_101237 may be a novel biomarker for MM, and it plays a significant role in the occurrence and development of MM." 1 Circular RNA circVAPA knockdown suppresses colorectal cancer cell growth process by regulating miR-125a/CREB5 axis. - hsa_circ_VAPA - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Our studies disclosed that circVAPA knockdown suppressed CRC cells cycle progression, migration, invasion and glycolysis partly by modulating miR-125a/CREB5 axis, suggesting a potential therapeutic strategy for CRC treatment." 3 circRNA_0084043 contributes to the progression of diabetic retinopathy via sponging miR-140-3p and inducing TGFA gene expression in retinal pigment epithelial cells. hsa_circ_0084043 - circRNA_0084043 DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR up-regulated loss of circRNA_0084043 depressed HG-induced damage via sponging miR-140-3p and regulating TGFA. 1 hsa_circ_0041795 contributes to human retinal pigment epithelial cells (ARPE 19) injury induced by high glucose via sponging miR-646 and activating VEGFC. hsa_circ_0041795 hsa_circ_C17orf81 - DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR up-regulated hsa_circ_0041795 contributes to human retinal pigment epithelial cells (ARPE 19) injury induced by high glucose via sponging miR-646 and activating VEGFC. 2 The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer. hsa_circ_0005320 hsa_circ_SEPT9 - DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "the circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer through circSEPT9/miR-637/LIF axis. Therefore, circSEPT9 could be used as a potential prognostic marker and therapeutical target for TNBC." 1 CircRNA_101951 promotes migration and invasion of colorectal cancer cells by regulating the KIF3A-mediated EMT pathway. - - circRNA_101951 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated CircRNA_101951 promotes migration and invasion of colorectal cancer cells by regulating the KIF3A-mediated EMT pathway. 1 "Circular RNA has_circ_0000527 participates in proliferation, invasion and migration of retinoblastoma cells via miR-646/BCL-2 axis." hsa_circ_0000527 - circ_0000527 DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated "Expression level of circ_0000527 in RB samples was significantly up-regulated compared to normal tissues, while miR-646 was markedly down-regulated. Overexpression of circ_0000527 promoted the viability, migration and invasion of RB cells, while miR-646 transfection had the opposite effects. Circ_0000527 sponged miR-646 to regulate the expression of BCL-2." 5 circKIF4A promotes tumorogenesis of glioma by targeting miR-139-3p to activate Wnt5a signaling. - hsa_circ_KIF4A - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circKIF4A was overexpressed in glioma, and knockdown of circKIF4A suppressed glioma progression via miR-139-3p/Wnt5a axis. The results indicated that circKIF4A may be a potential target for clinical treatment of glioma." 2 Hsa_circ_0007534 knockdown represses the development of colorectal cancer cells through regulating miR-613/SLC25A22 axis. hsa_circ_0007534 hsa_circ_DDX42 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "We demonstrated that circ_0007534 knockdown suppressed the growth of CRC cells by regulating miR-613/SLC25A22 axis, providing potential target for the treatment of CRC." 3 Association between hsa_circ_0006156 expression and incidence of gastric cancer. hsa_circ_0006156 hsa_circ_FNDC3B - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "The expression of hsa_circ_0006156 substantially declines in gastric cancer tissues, which is related to the differentiation degree, presence, or absence of lymph node metastasis and prognosis of gastric cancer patients. Therefore, hsa_circ_0006156 may clinically serve as a biomarker for the prognostic prediction of gastric cancer patients." 4 "Circ_CHFR expedites cell growth, migration and inflammation in ox-LDL-treated human vascular smooth muscle cells via the miR-214-3p/Wnt3/beta-catenin pathway." - hsa_circ_CHFR - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Circ_CHFR contributed to the progression of AS through the miR-214-3p/Wnt3/beta-catenin signals, which illuminated the molecular mechanism of AS and suggested circ_CHFR might be an index for AS treatment." 6 CircRNA SCARB1 Promotes Renal Cell Carcinoma Progression Via Mir- 510-5p/SDC3 Axis. - hsa_circ_SCARB1 - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated Circ-SCARB1 promotes RCC progression via sequestering miR-510-5p and indirectly up-regulating SDC3 expression. This provides a novel perspective for the pathogenesis of RCC and potential therapeutic targets for the treatment of RCC. 1 "Circular RNA 0060745, a Novel circRNA, Promotes Colorectal Cancer Cell Proliferation and Metastasis Through miR-4736 Sponging." hsa_circ_0060745 - circ_0060745 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circ_0060745 promoted CRC cell proliferation and metastasis via modulation of miR-4736/CSE1L signaling. The Circ_0060745/miR-4736/CSE1L axis might be a novel target for the treatment of CRC. 1 CircRNA ZNF609 Knockdown Suppresses Cell Growth via Modulating miR-188/ELF2 Axis in Nasopharyngeal Carcinoma. - hsa_circ_ZNF609 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "circ-ZNF609 depletion-repressed proliferation and cell cycle transition, and induced apoptosis of NPC cells via modulation of miR-188/ELF2 axis, providing potential targets for the therapy of NPC." 5 Circ-ABCB10 Contributes to Paclitaxel Resistance in Breast Cancer Through Let-7a-5p/DUSP7 Axis. - hsa_circ_ABCB10 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ-ABCB10 mediated PTX resistance, apoptosis, invasion and autophagy of BC cells via let-7a-5p/DUSP7 axis." 2 Circular RNA hsa_circ_0002052 promotes osteosarcoma via modulating miR-382/STX6 axis. hsa_circ_0002052 hsa_circ_PAPPA - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "circ-0002052, functioning as a sponge for miR-382, enhances the activation of Wnt/beta-catenin mediated by STX6 to stimulate the progression of OS, and circ-0002052 may be an underlying treatment target and a biomarker for prognosis of osteosarcoma." 5 Circ_0000285 promotes podocyte injury through sponging miR-654-3p and activating MAPK6 in diabetic nephropathy. hsa_circ_0000285 - circ_0000285 DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "MAPK6 was markedly suppressed by circ_0000285 siRNA, which was rescued by the decrease of miR-654-3p. These findings revealed that circ_0000285 promoted podocyte injury via sponging miR-654-3p and activating MAPK6 in DN." 1 Hsa_circ_0031288/hsa-miR-139-3p/Bcl-6 regulatory feedback circuit influences the invasion and migration of cervical cancer HeLa cells. hsa_circ_0031288 hsa_circ_PABPN1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "the hsa_circ_0031288/hsa-miR-139-3p/Bcl-6 regulatory axis affects cell migration and proliferation, and its mechanism may involve hsa_circ_0031288 acting as a sponge for hsa-miR-139-3p, thereby relieving the transcriptional inhibition of Bcl-6." 2 Piplartine attenuates the proliferation of hepatocellular carcinoma cells via regulating hsa_circ_100338 expression. - - hsa_circ_100338 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "circ-100338 played as a ceRNA in promoting the progression of HCC by sponging miR-141-3p, while piplartine can participate in the development of HCC by inhibiting the expression of circ-100338." 1 Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. - - circ_100251 DOID:1040 chronic lymphocytic leukemia chronic lymphocytic leukemia RT-qPCR up-regulated Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. 1 Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. - - circ_102680 DOID:1040 chronic lymphocytic leukemia chronic lymphocytic leukemia RT-qPCR down-regulated Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. 1 Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. - - circ_103997 DOID:1040 chronic lymphocytic leukemia chronic lymphocytic leukemia RT-qPCR down-regulated Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. 1 Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. - - circ_001430 DOID:1040 chronic lymphocytic leukemia chronic lymphocytic leukemia RT-qPCR down-regulated Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. 1 Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. - - circ_102683 DOID:1040 chronic lymphocytic leukemia chronic lymphocytic leukemia RT-qPCR down-regulated Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. 1 Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. - - circ_104424 DOID:1040 chronic lymphocytic leukemia chronic lymphocytic leukemia RT-qPCR up-regulated Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern. 1 circPRRC2A promotes angiogenesis and metastasis through epithelial-mesenchymal transition and upregulates TRPM3 in renal cell carcinoma. - hsa_circ_PRRC2A - DOID:4451 renal carcinoma renal carcinoma "RT-qPCR, microarray" up-regulated "our results indicate that circPRRC2A prevents the degradation of TRPM3, a tissue-specific oncogene, mRNA by sponging miR-514a-5p and miR-6776-5p. Moreover, circPRRC2A promotes tumor EMT and aggressiveness in patients with RCC." 1 Circular RNA SAMD4A controls adipogenesis in obesity through the miR-138-5p/EZH2 axis. hsa_circ_0004846 - hsa_circ_0004846 DOID:9970 obesity obesity "RT-qPCR, microarray" up-regulated "CircSAMD4A regulated preadipocyte differentiation by acting as a miR-138-5p sponge, and thus increasing EZH2 expression. These results suggested that circSAMD4A can serve as a potential target for obesity treatments and/or as a potential prognostic marker for obese patients following bariatric surgery." 1 Circular RNA hsa_circ_0072309 inhibits non-small cell lung cancer progression by sponging miR-580-3p. hsa_circ_0072309 - hsa_circ_0072309 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated These data showed that circ_0072309 inhibits the progression of NSCLC progression via blocking the expression of miR-580-3p. These findings revealed the anti-tumor role of circ_0072309 during the development of NSCLC and provided a novel diagnostic biomarker and potential therapy for NSCLC. 3 CircRNA BIRC6 promotes non-small cell lung cancer cell progression by sponging microRNA-145. - hsa_circ_BIRC6 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircRNA BIRC6 promotes non-small cell lung cancer cell progression by sponging microRNA-145. 5 "circTNFRSF21, a newly identified circular RNA promotes endometrial carcinoma pathogenesis through regulating miR-1227-MAPK13/ATF2 axis." hsa_circ_0001610 hsa_circ_TNFRSF21 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "circTNFRSF21, a newly identified circular RNA promotes endometrial carcinoma pathogenesis through regulating miR-1227-MAPK13/ATF2 axis." 3 "hsa_circ_0072387 Suppresses Proliferation, Metastasis, and Glycolysis of Oral Squamous Cell Carcinoma Cells by Downregulating miR-503-5p." hsa_circ_0072387 hsa_circ_HMGCS1 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "hsa_circ_0072387 inhibited OSCC progression by downregulating miR-503-5p, explicating that hsa_circ_0072387 could function as a novel potential therapeutic target for OSCC." 2 Integrated analyses reveal hsa_circ_0028883 as a diagnostic biomarker in active tuberculosis. hsa_circ_0028883 hsa_circ_DYNLL1 - DOID:399 tuberculosis tuberculosis RT-qPCR up-regulated "Hsa_circ_0028883 is a potentially reliable biomarker to diagnose active TB, but there remains a need to further study the mechanism in TB." 1 CircRNA_100876 sponges miR-136 to promote proliferation and metastasis of gastric cancer by upregulating MIEN1 expression. - - circRNA_100876 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "the promotion of GC growth and metastasis induced by circRNA_100876 interacted with miR-136 and MIEN1, indicating an emerging announcement for uncovering the potential mechanism of GC progression." 1 Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation. - hsa_circ_RGNEF - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circRGNEF suppresses BC progression by functioning as a miR-548 sponge to enhance KIF2C expression. Therefore, circRGNEF might be a candidate BC treatment target." 1 Genome-Wide Microarray Analysis of circRNAs Revealed Novel Biomarkers for Glioma Treatment and Their Promoting Effect on Glioma Progression. hsa_circ_0013520 hsa_circ_ST7L - DOID:0060108 brain glioma glioma "RT-qPCR, microarray" up-regulated "hsa_circ_0013520 and hsa_circ_0004379 were up-regulated in glioma tissues and cell lines, and their expression was positively correlated with poor clinical features of glioma patients, which may serve as novel biomarkers for glioma diagnosis and therapy." 1 Genome-Wide Microarray Analysis of circRNAs Revealed Novel Biomarkers for Glioma Treatment and Their Promoting Effect on Glioma Progression. hsa_circ_0004379 hsa_circ_YIPF6 - DOID:0060108 brain glioma glioma "RT-qPCR, microarray" up-regulated "hsa_circ_0013520 and hsa_circ_0004380 were up-regulated in glioma tissues and cell lines, and their expression was positively correlated with poor clinical features of glioma patients, which may serve as novel biomarkers for glioma diagnosis and therapy." 1 CircRNA hsa_circ_0087862 Acts as an Oncogene in Non-Small Cell Lung Cancer by Targeting miR-1253/RAB3D Axis. hsa_circ_0087862 hsa_circ_RAD23B - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated hsa_circ_0087862 acted as an oncogene in NSCLC by targeting miR-1253/RAB3D. 3 Identification of circRNA-miRNA-mRNA Networks for Exploring the Fundamental Mechanism in Lung Adenocarcinoma. hsa_circ_0072088 hsa_circ_ZFR - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated "Following the Agarose gel electrophoresis and qRT-PCR validation, hsa_circ_0072088 and hsa_circ_0008274 were chosen for further analysis." 1 Identification of circRNA-miRNA-mRNA Networks for Exploring the Fundamental Mechanism in Lung Adenocarcinoma. hsa_circ_0008274 hsa_circ_UGGT2 - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" down-regulated "Following the Agarose gel electrophoresis and qRT-PCR validation, hsa_circ_0072088 and hsa_circ_0008275 were chosen for further analysis." 1 Circular RNA Circ-ZNF609 Promotes Lung Adenocarcinoma Proliferation by Modulating miR-1224-3p/ETV1 Signaling. hsa_circ_0000615 hsa_circ_ZNF609 - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated "Circ-ZNF609 enhances LAUD progression by increasing oncogenic EVT1 expression via sponging miR-1224-3p, revealing that circ-ZNF609/miR-1224-3p/ETV1 axis may be a promising therapeutic target for LAUD treatment." 2 Serum Circular FoxO3a Serves as a Novel Prognostic Biomarker in Squamous Cervical Cancer. - hsa_circ_FoxO3a - DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated "serum circFoxO3a is a useful tool for predicting survival in SCC. CONCLUSION: Altogether, our findings demonstrated that serum circFoxO3a could serve as a potential novel noninvasive predictive prognostic biomarker and therapeutic target for SCC." 1 A novel circular RNA circENTPD7 contributes to glioblastoma progression by targeting ROS1. - hsa_circ_ENTPD7 - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "Taken together, these findings indicate that circRNA circENTPD7 promotes glioblastoma cell proliferation and motility by regulating miR-101-3p/ROS1." 1 Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis. - mmu_circ_FBXW4 - DOID:409 liver disease hepatic fibrosis "RT-qPCR, microarray" down-regulated "We found that circFBXW4 downregulated in liver fibrogenesis. Enforcing the expression of circFBXW4 inhibited HSCs activation, proliferation and induced apoptosis, attenuated mouse liver fibrogenesis injury and showed anti-inflammation effect. Mechanistically, circFBXW4 directly targeted to miR-18b-3p to regulate the expression of FBXW7 in HF. Conclusions: circFBXW4 may act as a suppressor of HSCs activation and HF through the circFBXW4/miR-18b-3p/FBXW7 axis. Our findings identify that circFBXW4 serves as a potential biomarker for HF therapy." 1 Circular RNA expression profile of lung squamous cell carcinoma: identification of potential biomarkers and therapeutic targets. hsa_circ_0014235 hsa_circ_S100A2 - DOID:3907 lung squamous cell carcinoma lung squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "clinical studies indicated that hsa_circ_0014235 and hsa_circ_0025580 could serve as novel diagnostic biomarkers for LUSC. Taken together, our study revealed exosomal circRNAs expression profile in LUSC for the first time and showed the important diagnostic potential for circRNAs in LUSC." 1 Circular RNA expression profile of lung squamous cell carcinoma: identification of potential biomarkers and therapeutic targets. hsa_circ_0025580 hsa_circ_SLCO1B3 - DOID:3907 lung squamous cell carcinoma lung squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "clinical studies indicated that hsa_circ_0014235 and hsa_circ_0025581 could serve as novel diagnostic biomarkers for LUSC. Taken together, our study revealed exosomal circRNAs expression profile in LUSC for the first time and showed the important diagnostic potential for circRNAs in LUSC." 1 Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood. - hsa_circ_CAMSAP1 - DOID:9352 type 2 diabetes mellitus type 2 diabetes RT-qPCR up-regulated "Some islet circRNAs are also expressed in peripheral blood and the expression of one, circCAMSAP1, correlates with diabetes status. These findings highlight the potential of circRNAs as biomarkers for T2D." 1 CircSMC3 regulates gastric cancer tumorigenesis by targeting miR-4720-3p/TJP1 axis. hsa_circ_0000260 hsa_circ_SMC3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "circSMC3 decreased miR-4720-3p expression by acting as a miRNA sponge, and tight junction protein 1 (TJP1) 3UTR was identified to be the target of miR-4720-3p, contributing to a circSMC3/miR-4720-3p/TJP1 axis. Thus, our results indicate that circSMC3 promotes gastric cancer cell proliferation and motility through miR-4720-3p/TJP1." 1 Circular RNA expression profile of Alzheimer disease and its clinical significance as biomarkers for the disease risk and progression. hsa_circ_0003611 hsa_circ_LPAR1 - DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC40C were decreased in AD patients compared with Ctrl subjects." 3 Circular RNA expression profile of Alzheimer disease and its clinical significance as biomarkers for the disease risk and progression. hsa_circ_0002945 hsa_circ_AXL - DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC39C were decreased in AD patients compared with Ctrl subjects." 3 Circular RNA expression profile of Alzheimer disease and its clinical significance as biomarkers for the disease risk and progression. hsa_circ_0032253 hsa_circ_GPHN - DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC40C were decreased in AD patients compared with Ctrl subjects." 1 Circular RNA expression profile of Alzheimer disease and its clinical significance as biomarkers for the disease risk and progression. hsa_circ_0030777 hsa_circ_PCCA - DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC41C were decreased in AD patients compared with Ctrl subjects." 1 Circular RNA expression profile of Alzheimer disease and its clinical significance as biomarkers for the disease risk and progression. hsa_circ_0031258 hsa_circ_HAUS4 - DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC42C were decreased in AD patients compared with Ctrl subjects." 1 Circular RNA expression profile of Alzheimer disease and its clinical significance as biomarkers for the disease risk and progression. hsa_circ_0000775 hsa_circ_KIF18B - DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC43C were decreased in AD patients compared with Ctrl subjects." 1 Circular RNA expression profile of Alzheimer disease and its clinical significance as biomarkers for the disease risk and progression. hsa_circ_0047285 hsa_circ_TTC39C - DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC44C were decreased in AD patients compared with Ctrl subjects." 1 CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:2913 acute pancreatitis acute pancreatitis RT-qPCR up-regulated "circHIPK3 promotes pyroptosis in acinar cells through regulation of the miR-193a-5p/GSDMD axis, which eventually aggravates AP disease." 1 Inhibition of hsa_circ_0002570 suppresses high-glucose-induced angiogenesis and inflammation in retinal microvascular endothelial cells through miR-1243/angiomotin axis. hsa_circ_0002570 hsa_circ_FAM73A - DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR up-regulated "Our results showed that, in DR patients and high-glucose-induced hRMECs, miR-1243, circ_0002570, and angiomotin were all abnormally expressed. MiR-1243 could directly and competitively bind to both circ_0002570 and angiomotin mRNA to inhibit their expression. Moreover, circ_0002570 suppressed the abilities of proliferation, migration, and angiogenesis in hRMECs induced by high glucose, which was dependent on miR-1243-angiomotin axis. Furthermore, circ_0002570 could upregulate angiomotin by targeting miR-1243 to mediate the dysfunction of hRMECs induced by high glucose." 1 Hsa_circ_0091074 regulates TAZ expression via microRNA_1297 in triple negative breast cancer cells. hsa_circ_0091074 hsa_circ_TCONS_00016926 - DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "The current results indicate that miR_1297 serves as a suppressor of breast cancer cell proliferation and invasiveness, and that this can be partially reversed by hsa_circ_0091074, suggesting that the hsa_circ_0091074/miR_1297/TAZ/TEAD4 axis may represent a potential therapeutic target for triple negative breast cancer in the future." 1 Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma. - - circ_081069 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, microarray" up-regulated "The present results suggested that circRNAs may be involved in TSCC development, and understanding the interaction between circ_081069 and miR_665 may facilitate the development of novel diagnostic and therapeutic targets for TSCC." 1 Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma. - - circ_045179 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, microarray" up-regulated "The present results suggested that circRNAs may be involved in TSCC development, and understanding the interaction between circ_081069 and miR_666 may facilitate the development of novel diagnostic and therapeutic targets for TSCC." 1 Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma. - - circ_087212 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, microarray" down-regulated "The present results suggested that circRNAs may be involved in TSCC development, and understanding the interaction between circ_081069 and miR_667 may facilitate the development of novel diagnostic and therapeutic targets for TSCC." 1 Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma. - - circ_000317 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, microarray" down-regulated "The present results suggested that circRNAs may be involved in TSCC development, and understanding the interaction between circ_081069 and miR_668 may facilitate the development of novel diagnostic and therapeutic targets for TSCC." 1 Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma. - - circ_000780 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, microarray" down-regulated "The present results suggested that circRNAs may be involved in TSCC development, and understanding the interaction between circ_081069 and miR_669 may facilitate the development of novel diagnostic and therapeutic targets for TSCC." 1 Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma. - - circ_102039 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, microarray" down-regulated "The present results suggested that circRNAs may be involved in TSCC development, and understanding the interaction between circ_081069 and miR_670 may facilitate the development of novel diagnostic and therapeutic targets for TSCC." 1 Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma. - - circ_003251 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, microarray" down-regulated "The present results suggested that circRNAs may be involved in TSCC development, and understanding the interaction between circ_081069 and miR_671 may facilitate the development of novel diagnostic and therapeutic targets for TSCC." 1 circRNA_001275 upregulates Wnt7a expression by competitively sponging miR_370_3p to promote cisplatin resistance in esophageal cancer. - - circRNA_001275 DOID:5041 esophageal cancer esophageal cancer "RT-qPCR, microarray" up-regulated circRNA_001275 upregulates Wnt7a expression by competitively sponging miR_370_3p to promote cisplatin resistance in esophageal cancer. 1 Circular RNA hsa_circ_0001380 in peripheral blood as a potential diagnostic biomarker for active pulmonary tuberculosis. hsa_circ_0001380 hsa_circ_UBXN7 - DOID:2957 pulmonary tuberculosis pulmonary tuberculosis RT-qPCR down-regulated "hsa_circ_0001380 was downregulated in the peripheral blood of patients with APTB, and could serve as a diagnostic biomarker." 1 Circular RNA 0016788 displays as a biomarker for tumor progression and poor prognosis in surgical hepatocellular carcinoma patients. - - circ_0016788 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0016788 displays the potential as a biomarker for assisting personalized treatment, tumor management, and prognosis surveillance in surgical HCC patients." 1 A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289. - - circ_0018289 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Circ_0018289 could serve as a potential disease monitoring and prognostic biomarker in cervical cancer patients. 2 Circular RNA circ-CDYL sponges miR-1180 to elevate yes-associated protein in multiple myeloma. - hsa_circ_CDYL - DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated Circular RNA circ-CDYL sponges miR-1180 to elevate yes-associated protein in multiple myeloma. 1 Circular RNA Circ100084 functions as sponge of miR_23a_5p to regulate IGF2 expression in hepatocellular carcinoma. - - hsa_circRNA_100084 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated hsa_circRNA_100084 could promote the expression of IGF2 by acting as a sponge of hsa_miR_23a_5p in liver cancer cells. 1 Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. - - hsa_circRNA_084725 DOID:869 cholesteatoma cholesteatoma microarray up-regulated Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. 1 Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. - - hsa_circRNA_103276 DOID:869 cholesteatoma cholesteatoma microarray up-regulated Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. 1 Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. - - hsa_circRNA_006562 DOID:869 cholesteatoma cholesteatoma microarray down-regulated Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. 1 Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. - - hsa_circRNA_101458 DOID:869 cholesteatoma cholesteatoma microarray down-regulated Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. 1 Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. - - hsa_circRNA_101965 DOID:869 cholesteatoma cholesteatoma microarray down-regulated Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. 1 Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. - - hsa_circRNA_102747 DOID:869 cholesteatoma cholesteatoma microarray down-regulated Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma. 1 "Circ_0002770, acting as a competitive endogenous RNA, promotes proliferation and invasion by targeting miR-331-3p in melanoma." hsa_circ_0002770 - circ_0002770 DOID:1909 melanoma melanoma microarray up-regulated "circ_0002770 facilitated melanoma cell proliferation, invasion and migration by sponging miR-331-3p and modulating DUSP5 and TGFBR1." 1 Screening Circular RNAs Related to Acquired Gefitinib Resistance in Non-small Cell Lung Cancer Cell Lines. hsa_circ_0000567 hsa_circ_SETD3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" up-regulated We further used hsa_circ_0000567 and hsa_circ_0006867 as key circRNAs to construct circRNA-miRNA-mRNA networks. Several target mRNAs of these two circRNAs had been shown to significantly associate with the overall survival of patients with lung cancer. 3 Screening Circular RNAs Related to Acquired Gefitinib Resistance in Non-small Cell Lung Cancer Cell Lines. hsa_circ_0006867 hsa_circ_LRBA - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" down-regulated We further used hsa_circ_0000567 and hsa_circ_0006868 as key circRNAs to construct circRNA-miRNA-mRNA networks. Several target mRNAs of these two circRNAs had been shown to significantly associate with the overall survival of patients with lung cancer. 1 Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis. - hsa_circ_SERPINA3 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis. 1 Overexpression of circARF3 mitigates TNF-alpha-induced inflammatory damage by up-regulating miR-125b. hsa_circ_0026070 hsa_circ_ARF3 - DOID:9588 encephalitis encephalitis RT-qPCR up-regulated overexpression of circARF3 mitigated cell inflammatory damage via inactivation of JNK and NF-kappaB pathways and thereby up-regulation of miR-125b. 1 CircRNA_0048211 protects postmenopausal osteoporosis through targeting miRNA-93-5p to regulate BMP2. - - circRNA_0048211 DOID:11476 osteoporosis postmenopausal osteoporosis RT-qPCR down-regulated "CircRNA_0048211 negatively targets miRNA-93-5p to upregulate BMP2, thus alleviating the progression of PMOP." 1 CircPSM3 inhibits the proliferation and differentiation of OA chondrocytes by targeting miRNA-296-5p. - hsa_circ_PSMC3 - DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated CircPSM3 was upregulated in OA chondrocytes. CircPSM3 participated in the proliferation and differentiation of OA chondrocytes through targeted binding to miRNA-296-5p. CircPSM3 may become a potential therapeutic target for osteoarthritis treatment. 1 Circular RNA circCNOT6L regulates cell development through modulating miR-384/FN1 axis in esophageal squamous cell carcinoma. - hsa_circ_CNOT6L - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated circCNOT6L positively regulated the development of ESCC cells via modulating miR-384/FN1 axis. Our findings provided a theoretical basis for the therapy of ESCC patients. 3 CircRNA EPB41L2 inhibits tumorigenicity of lung adenocarcinoma through regulating CDH4 by miR-211-5p. - hsa_circ_EPB41L2 - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "Circ_EPB41L2 functioned as a tumor suppressor to inhibit the proliferation, migration and invasion through regulating CDH4 by miR-211-5p in LUAD cells, suggesting a new understanding on the tumorigenesis of LUAD and novel molecular therapeutic targets." 2 "Circular RNA circCRIM1 suppresses lung adenocarcinoma cell migration, invasion, EMT, and glycolysis through regulating miR-125b-5p/BTG2 axis." - hsa_circ_CRIM1 - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "CircCRIM1 was lowly expressed in LUAC. Moreover, circCRIM1 functioned as a sponge of miR-125b-5p to improve BTG2 expression, thereby suppressing LUAC development. Our finding indicated that circCRIM1 could be considered as a biomarker and target for the diagnosis and therapy of LUAC patients." 2 circHMCU Promotes Proliferation and Metastasis of Breast Cancer by Sponging the let-7 Family. - hsa_circ_HMCU - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circHMCU exerted oncogenic functions in breast cancer and could be a used as a novel biomarker in the diagnosis and prognosis of breast cancer. 2 CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-alpha in TMJ osteoarthritis. hsa_circ_0000448 hsa_circ_GCN1L1 - DOID:8398 osteoarthritis temporomandibular joint osteoarthritis RNA-seq up-regulated CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-alpha in TMJ osteoarthritis. 2 Assessing circular RNAs in Alzheimer disease and frontotemporal lobar degeneration. - hsa_circ_HOMER1 - DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR down-regulated "Two circRNAs (circHOMER1 and circKCNN2) also showed significant expression alterations in the group of FTLD-Tau and FTLD-TDP43, respectively. Overall, these results reinforce the conception that expression of circRNAs is different in AD, and also suggest a wider involvement of this particular class of RNA in other neurodegenerative dementias." 1 Assessing circular RNAs in Alzheimer disease and frontotemporal lobar degeneration. - hsa_circ_KCNN2 - DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR down-regulated "Two circRNAs (circHOMER1 and circKCNN2) also showed significant expression alterations in the group of FTLD-Tau and FTLD-TDP44, respectively. Overall, these results reinforce the conception that expression of circRNAs is different in AD, and also suggest a wider involvement of this particular class of RNA in other neurodegenerative dementias." 1 Circular RNA MYLK promotes tumour growth and metastasis via modulating miR-513a-5p/VEGFC signalling in renal cell carcinoma. - hsa_circ_MYLK - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated "circMYLK has an oncogenic role in RCC growth and metastasis by modulating miR-513a-5p/VEGFC signalling. Thus, circMYLK has potential as a diagnostic biomarker and therapeutic target in the treatment of RCC." 1 Knockdown of circAPLP2 Inhibits Progression of Colorectal Cancer by Regulating miR-485-5p/FOXK1 Axis. hsa_circ_0000372 hsa_circ_APLP2 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circAPLP2 knockdown inhibited CRC progression through regulating miR-485-5p/FOXK1 axis, providing a novel avenue for treatment of CRC." 1 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. - hsa_circ_Cznf532 Cznf532 DOID:8947 diabetic retinopathy diabetic retinopathy "RT-qPCR, microarray" up-regulated these data identify a circRNA-mediated mechanism that coordinates pericyte biology and vascular homeostasis in DR. Induction of cZNF532 or antagonism of miR-29a-3p is an exploitable therapeutic approach for the treatment of DR. 1 Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson Disease in a Mouse Model. mmu_circ_0003292 - mmu_circRNA_0003292 DOID:14330 Parkinson disease Parkinson disease RT-qPCR down-regulated "Seven DE-cirRNAs were selected for qRT-PCR verification, where the expressions were consistent with the sequencing analysis." 1 Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson Disease in a Mouse Model. mmu_circ_0000870 - mmu_circRNA_0000870 DOID:14330 Parkinson disease Parkinson disease RT-qPCR down-regulated "Seven DE-cirRNAs were selected for qRT-PCR verification, where the expressions were consistent with the sequencing analysis." 1 Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson Disease in a Mouse Model. mmu_circ_0004144 - mmu_circRNA_0004144 DOID:14330 Parkinson disease Parkinson disease RT-qPCR down-regulated "Seven DE-cirRNAs were selected for qRT-PCR verification, where the expressions were consistent with the sequencing analysis." 1 Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson Disease in a Mouse Model. mmu_circ_0000468 - mmu_circRNA_0000468 DOID:14330 Parkinson disease Parkinson disease RT-qPCR down-regulated "Seven DE-cirRNAs were selected for qRT-PCR verification, where the expressions were consistent with the sequencing analysis." 1 Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson Disease in a Mouse Model. mmu_circ_0013321 - mmu_circRNA_0013321 DOID:14330 Parkinson disease Parkinson disease RT-qPCR down-regulated "Seven DE-cirRNAs were selected for qRT-PCR verification, where the expressions were consistent with the sequencing analysis." 1 Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson Disease in a Mouse Model. mmu_circ_0001320 - mmu_circRNA_0001320 DOID:14330 Parkinson disease Parkinson disease RT-qPCR up-regulated "Seven DE-cirRNAs were selected for qRT-PCR verification, where the expressions were consistent with the sequencing analysis." 1 Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson Disease in a Mouse Model. mmu_circ_0000517 - mmu_circRNA_0000517 DOID:14330 Parkinson disease Parkinson disease RT-qPCR up-regulated "Seven DE-cirRNAs were selected for qRT-PCR verification, where the expressions were consistent with the sequencing analysis." 1 "circ_0067934 increases bladder cancer cell proliferation, migration and invasion through suppressing miR-1304 expression and increasing Myc expression levels." hsa_circ_0067934 - circ_0067934 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circ_0067934 was demonstrated to increase bladder cancer cell proliferation, migration and invasion through promoting Myc expression levels via the suppression of miR-1304 expression." 1 CDR1as/miR-7/CKAP4 axis contributes to the pathogenesis of abdominal aortic aneurysm by regulating the proliferation and apoptosis of primary vascular smooth muscle cells. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm RT-qPCR down-regulated "CDR1as also decreased caspase 3/7 activity, which was reversed by miR-7 mimics. miR-7 increased the activity of caspase 3/7, which was again reversed by the overexpression of CKAP4. Therefore, CDR1as, miR-7 and CKAP4 may act in the same pathway to regulate VSMC proliferation and apoptosis." 1 Comprehensive circular RNA profiling reveals the regulatory role of circRNA_0007694 in papillary thyroid carcinoma. hsa_circ_0007694 hsa_circ_ATM - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, RNA-seq" down-regulated "Over-expression of hsa_circ_0007694 promoted apoptosis and inhibited proliferation, migration, and invasion in PTC cells in vitro, and decreased tumor growth in vivo. Transcriptome sequence analysis suggested 129 differentially expressed genes between PTC tissue and paired pericarcinomatous tissue. KEGG analysis and western blotting indicated that the PI3K/AKT/mTOR and Wnt signaling networks are most likely to be related to hsa_circ_0007694 in thyroid cancer. " 1 Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway. hsa_circ_0000745 - circ-0000745 DOID:9952 acute lymphoblastic leukemia acute lymphoblastic leukemia RT-qPCR up-regulated upregulated circ-0000745 in leukemia cells could promoter cell viability by increasing the activation of ERK pathway. 2 circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer. hsa_circ_0086375 hsa_circ_NFIB1 - DOID:1793 pancreatic cancer pancreatic cancer RNA-seq down-regulated "circNFIB1 attenuated the oncogenic effect of miR-486-5p and consequently upregulated PIK3R1 expression, which further downregulated VEGF-C expression through inhibition of the PI3K/Akt pathway, and ultimately suppressed lymphangiogenesis and LN metastasis in PDAC." 1 The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC. - hsa_circ_FAM169A - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" up-regulated "circ-FAM169A sequestered miR-583, which could potentially upregulate BTRC, an inducer of the NF-kappaB signaling pathway. In conclusion, the present study revealed that circ-FAM169A promotes IDD development via miR-583/BTRC signaling." 2 "Hsa_circ_0102272 serves as a prognostic biomarker and regulates proliferation, migration and apoptosis in thyroid cancer." hsa_circ_0102272 hsa_circ_RTN1 - DOID:1781 thyroid gland cancer thyroid cancer "RT-qPCR, RNA-seq" up-regulated Hsa_circ_0102272 displays oncogenic function via repressing malignant biological properties and serves as a prognostic biomarker in TC patients. 3 Plasma exo-hsa_circRNA_0056616: A potential biomarker for lymph node metastasis in lung adenocarcinoma. hsa_circ_0056616 - hsa_circRNA_0056616 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated CXCR4 was higher in the lung adenocarcinoma tissues with lymph node metastasis. Higher plasma levels of exo-hsa_circRNA_0056616 in these patients also suggest that this circRNA represents a potential biomarker for lymph node metastasis predictor in lung adenocarcinoma. 1 circNFIC suppresses breast cancer progression by sponging miR-658. hsa_circ_0002018 hsa_circ_NFIC - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated "Our study highlighted the regulatory function of the circNFIC/miR-658/UPK1A pathway in breast cancer progression, which could be a potential therapeutic target for breast cancer." 1 Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells. - hsa_circ_RIC3 - DOID:62 aortic valve disease aortic valve calcification "RT-qPCR, microarray" up-regulated "melatonin ameliorates aortic valve calcification via the regulation of CircRIC3/miR-204-5p/DPP4 signaling in hVICs; therefore, melatonin medication might be considered a novel pharmaceutical strategy for CAVD treatment." 1 Circ_0067934 correlates with poor prognosis and promotes laryngeal squamous cell cancer progression by sponging miR-1324. hsa_circ_0067934 - Circ_0067934 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "Circ_0067934 may function as an oncogene in LSCC, which provided a feasible prognostic biomarker and therapeutic target for LSCC." 1 The decreased circular RNA hsa_circ_0072309 promotes cell apoptosis of ischemic stroke by sponging miR-100. hsa_circ_0072309 hsa_circ_LIFR - DOID:4451 renal carcinoma renal carcinoma RT-qPCR down-regulated "the circ_0072309-miR-100-mTOR regulatory axis could alleviate IS, and it may be a potential target for the treatment of IS." 2 Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis. hsa_circ_0009065 hsa_circ_BFAR - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq, microarray" up-regulated "Our findings showed that circBFAR plays an important role in the proliferation and metastasis of PDAC, which might be explored as a potential prognostic marker and therapeutic target for PDAC." 1 Hsa_circ_0017639 expression promotes gastric cancer proliferation and metastasis by sponging miR-224-5p and upregulating USP3. hsa_circ_0017639 hsa_circ_SFMBT2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "hsa_circ_0017639 takes part in GC progression through regulating the miR-224-5p/USP3 axis, highlighting its potential as an effective GC therapeutic target." 4 CircRNA WHSC1 targets the miR-646/NPM1 pathway to promote the development of endometrial cancer. - hsa_circ_WHSC1 circWHSC1 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated CircWHSC1 promotes endometrial cancer development through sponging miR-646 and targeting NPM1. 1 Circular RNA circ_0020710 drives tumor progression and immune evasion by regulating the miR-370-3p/CXCL12 axis in melanoma. hsa_circ_0020710 - circ_0020710 DOID:1909 melanoma melanoma RT-qPCR up-regulated "Elevated circ_0020710 drives tumor progression via the miR-370-3p/CXCL12 axis, and circ_0020710 is a potential target for melanoma treatment." 1 circ_103809 promotes breast cancer progression by regulating the PI3K/AKT signaling pathway. - - hsa_circ_103809 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "hsa_circ_103809 was highly expressed in breast cancer tissues and cells, and may play an oncogene role in the development of breast cancer, and is expected to become a new target for breast cancer therapy." 1 Down-regulation of circDMNT3B is conducive to intestinal mucosal permeability dysfunction of rats with sepsis via sponging miR-20b-5p. - rno_circ_DMNT3B circDMNT3B DOID:0040085 bacterial sepsis sepsis RT-qPCR up-regulated "Down-regulation of circDMNT3B was conducive to the dysfunction of intestinal mucosal permeability via sponging miR-20b-5p in sepsis rats, which may provide the novel strategy for sepsis treatment in the future" 1 CircularRNA-9119 promotes the proliferation of cervical cancer cells by sponging miR-126/MDM4. - - circ9119 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Our findings demonstrated that circ9119 acts as an oncogene in CC. Our study provides evidence for targeting circ9119 for the treatment of CC. 1 Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression. - hsa_circ_CCDC9 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated "CircCCDC9 functions as a tumor suppressor in inhibiting the progression of GC through miR-6792-3p/CAV1 axis, which has provided an exploitable biomarker and therapeutic target for patients with GC." 1 N(6)-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1-Regulated Astrocyte Dysfunction and Depressive-like Behaviors. - mmu_circ_STAG1 circSTAG1 DOID:1470 major depressive disorder major depressive disorder RNA-seq down-regulated "Our findings dissect the functional link between circSTAG1 and m(6)A methylation in the context of MDD, providing evidence that circSTAG1 may be a novel therapeutic target for MDD." 1 Oncogenic circular RNA Hsa-circ-000684 interacts with microRNA-186 to upregulate ZEB1 in gastric cancer. - - hsa-circ-000684 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "hsa-circ-000684 reduces the miR-186 expression which leads to an increase in the ZEB1 expression and, consequently, promotion of GC progression." 1 Comprehensive circular RNA profiling reveals that hsa_circ_0001368 is involved in growth hormone-secreting pituitary adenoma development. hsa_circ_0001368 hsa_circ_KLHL24 - DOID:3829 pituitary adenoma pituitary adenoma "RT-qPCR, microarray" up-regulated "Among these differentially expressed circRNAs, hsa_circ_0001368 was verified significant up-regulated by qRT-PCR, which was specific up-regulated in GHPA and correlated with the invasiveness and serum GH level of GHPA; functional studies indicated that knockdown of hsa_circ_0001368 significantly inhibited the proliferation, invasion and GH secreting level of GHPA primary culture cells. Moreover, hsa_circ_0001368 had a significant positive correlation with the pituitary-specific transcription factor Pit-1." 1 Circular RNA circ_0000337 contributes to osteosarcoma via the miR-4458/BACH1 pathway. hsa_circ_0000337 - circ_0000337 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ_0000337 promoted OS progression via sponging miR-4458 and thus elevating BACH1 expression, offering rational therapeutic target for OS." 1 Identification of candidate lncRNAs and circRNAs regulating WNT3/beta-catenin signaling in essential hypertension. hsa_circ_0039388 hsa_circ_RBL2 - DOID:10825 essential hypertension essential hypertension "RT-qPCR, RNA-seq" up-regulated "Our analysis identified two lncRNAs, transmembrane protein 183A pseudogene (LOC646616) and leucine aminopeptidase 3 pseudogene 2 (LAP3P2), and two circRNAs, hsa_circ_0039388 and hsa_circ_0038648, that are highly co-expressed with both wingless-type MMTV integration site family member 3 (WNT3) and calcium/calmodulin-dependent protein kinase II inhibitor 2 (CAMK2N2) mRNAs and also share common microRNA binding sites with these two transcripts." 1 Identification of candidate lncRNAs and circRNAs regulating WNT3/beta-catenin signaling in essential hypertension. hsa_circ_0038648 hsa_circ_PRKCB - DOID:10825 essential hypertension essential hypertension "RT-qPCR, RNA-seq" up-regulated "Our analysis identified two lncRNAs, transmembrane protein 183A pseudogene (LOC646616) and leucine aminopeptidase 3 pseudogene 2 (LAP3P2), and two circRNAs, hsa_circ_0039388 and hsa_circ_0038648, that are highly co-expressed with both wingless-type MMTV integration site family member 3 (WNT3) and calcium/calmodulin-dependent protein kinase II inhibitor 2 (CAMK2N2) mRNAs and also share common microRNA binding sites with these two transcripts." 1 circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS. hsa_circ_0005615 hsa_circ_NFATC3 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq, microarray" up-regulated circ5615 exerted oncogenic function as competing endogenous RNA (ceRNA) of miR-149-5p to release TNKS and activated Wnt/beta-catenin pathway. 3 The circular RNA circMAST1 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-1299 and regulating CTNND1 expression. - hsa_circ_MAST1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated circMAST1 elicits HCC progression by sponging miRNA-1299 and stabilizing CTNND1. 1 Genome-Wide Analysis of circular RNAs and validation of hsa_circ_0006719 as a potential novel diagnostic biomarker in congenital scoliosis patients. hsa_circ_0006719 hsa_circ_VKORC1 - DOID:60249 scoliosis scoliosis "RT-qPCR, RNA-seq" up-regulated Only hsa_circ_0006719 was confirmed to have a higher expression level in the CS group than the healthy control group . 1 Exosomes derived from circRNA Rtn4-modified BMSCs attenuate TNF-alpha-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a. - hsa_circ_Rtn4 circ-Rtn4 DOID:11476 osteoporosis osteoporosis RT-qPCR up-regulated Exosomes derived from circRNA Rtn4-modified BMSCs attenuate TNF-alpha-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a. 1 CircRNA ACAP2 induces myocardial apoptosis after myocardial infarction by sponging miR-29. - rno_circ_ACAP2 circ_ACAP2 DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated The expression of circ ACAP2 increased in cardiomyocytes after MI and promoted apoptosis by binding to miR-29. 1 CircSMARCA5 Facilitates the Progression of Prostate Cancer Through miR-432/PDCD10 Axis. - hsa_circ_SMARCA5 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated CircSMARCA5 deteriorated PCa through the miR-432/PDCD10 axis. CircSMARCA5/miR-432/PDCD10 axis might be an underlying therapeutic target for PCa treatment. 3 "Circular RNA KIF4A promotes cell migration, invasion and inhibits apoptosis through miR-152/ZEB1 axis in breast cancer." - hsa_circ_KIF4A - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Silencing of circKIF4A hampered cell metastasis and promoted apoptosis by regulating ZEB1 via sponging miR-152 in BC. 4 Comprehensive profiling of circRNAs and the tumor suppressor function of circHIPK3 in clear cell renal carcinoma. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:4451 renal carcinoma renal carcinoma "RT-qPCR, RNA-seq" down-regulated "Overexpression of circHIPK3 effectively suppressed CCRCC cell invasion and migration in vitro, and inhibited CCRCC cell proliferation in vitro and in vivo. Moreover, bioinformatic analysis and luciferase reporter assay showed that circHIPK3 targeted miR-637 in CCRCC cells. " 1 Circular RNA circMDM2 accelerates the glycolysis of oral squamous cell carcinoma by targeting miR-532-3p/HK2. - hsa_circ_MDM2 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Mechanistically, circMDM2 sponged miR-532-3p to promote the hexokinase 2 (HK2), forming the circMDM2/miR-532-3p/HK2 axis. In conclusion, these findings demonstrated that circMDM2/miR-532-3p/HK2 axis promotes the proliferation and glycolysis of OSCC, rendering a potential diagnostic biomarker and prospective therapeutic target for OSCC." 1 A circular RNA derived from DAB1 promotes cell proliferation and osteogenic differentiation of BMSCs via RBPJ/DAB1 axis. - hsa_circ_DAB1 - DOID:12347 osteogenesis imperfecta osteogenesis RT-qPCR up-regulated "knocking down either RBPJ or DAB1 partially recovered BMSC proliferation and osteogenic differentiation that was suppressed by circ-DAB1 overexpression. Conclusively, circ-DAB1 promotes cell proliferation and osteogenic differentiation of BMSCs via NOTCH/RBPJ pathway." 1 Circular RNA ABCB10 promotes non-small cell lung cancer progression by increasing E2F5 expression through sponging miR-584-5p. - hsa_circ_ABCB10 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated Circular RNA ABCB10 promotes non-small cell lung cancer progression by increasing E2F5 expression through sponging miR-584-5p. 4 Circular RNA hsa_circ_0008285 inhibits colorectal cancer cell proliferation and migration via the miR-382-5p/PTEN axis. hsa_circ_0008285 hsa_circ_CDYL - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "knockdown of circ_0008285 promoted CRC cell proliferation and migration in vitro. Mechanistically, by using RNA-sequencing, bioinformatics analysis, dual-luciferase reporter assay, and western blotting, we determined that circ_0008285 suppressed the PI3K/AKT pathway via the miR-382-5p/PTEN axis." 1 Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR up-regulated "CDR1as could bind with miR-641 and accelerate miR-641 degradation, which possibly leads to the upregulation of the relative mRNA levels of AKT3 and mTOR in RBE cells. " 2 Overexpression of hsa_circ_0136666 predicts poor prognosis and initiates osteosarcoma tumorigenesis through miR-593-3p/ZEB2 pathway. hsa_circ_0136666 - - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Overexpression of hsa_circ_0136666 predicts poor prognosis and initiates osteosarcoma tumorigenesis through miR-593-3p/ZEB2 pathway. 2 Circular RNA Circ_0025033 Promotes the Evolvement of Ovarian Cancer Through the Regulation of miR-330-5p/KLK4 Axis. hsa_circ_0025033 - Circ_0025033 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated This study demonstrated that circ_0025033 contributed to the progression of OC via the miR-330-5p/KLK4 axis and might be a candidate target in the identification and treatment of OC. 4 Circular RNA circNRIP1 Sponges microRNA-138-5p to Maintain Hypoxia-Induced Resistance to 5-Fluorouracil Through HIF-1alpha-Dependent Glucose Metabolism in Gastric Carcinoma. - hsa_circ_NRIP1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circNRIP1 functioned as a miR-138-5p sponge to enhance hypoxia-induced resistance to 5-FU through modulation of HIF-1alpha-dependent glycolysis, which provides a novel potential approach to overcome hypoxia-induced 5-FU resistance in GC." 6 "Circ_100565 promotes proliferation, migration and invasion in non-small cell lung cancer through upregulating HMGA2 via sponging miR-506-3p." - - Circ_100565 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated "Circ_100565 increased HMGA2 expression to promote proliferation, migration and invasion in NSCLC via absorbing miR-506-3p. Our findings provided a new biomarker for NSCLC therapy." 1 Circular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis. hsa_circ_0002375 hsa_circ_KITLG - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, RNA-seq" up-regulated "CircRNA-miRNA-target gene network analysis revealed a potential mechanism that hsa_circ_0002375 (circKITLG) may be involved in NPC through sponging up miR-3198 and interfering with its downstream targets. Silencing of circKITLG inhibited NPC cell proliferation, migration, and invasion in vitro. " 1 Circular RNA circ_0001368 inhibited growth and invasion in renal cell carcinoma by sponging miR-492 and targeting LATS2. hsa_circ_0001368 - circ_0001368 DOID:4451 renal carcinoma renal carcinoma RT-qPCR down-regulated circ_0001368 upregulated the LATS2 expression and suppressed ACHN and 786-O cell growth and invasion by sponging miR-492. circ_0001368 suppressed the proliferation ability of 786-O in vivo. 1 Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis. hsa_circ_0082002 hsa_circ_MET - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "circMET is an onco-circRNA that induces HCC development and immune tolerance via the Snail/DPP4/CXCL10 axis. Furthermore, sitagliptin may enhance the efficacy of anti-PD1 therapy in a subgroup of patients with HCC." 1 Circular RNA circ_0007142 Facilitates Colorectal Cancer Progression by Modulating CDC25A Expression via miR-122-5p. hsa_circ_0007142 - circ_0007142 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0007142 sponged miR-122-5p and CDC25A was a target of miR-122-5p. Circ_0007142 knockdown impeded cell proliferation, colony formation, migration, and invasion in CRC cells by regulating miR-122-5p. " 3 The interaction between circular RNA hsa_circ_0000285 and miR-599 in thyroid cancer. hsa_circ_0000285 hsa_circ_HIPK3 - DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated Hsa_circ_0000285 could enhance cell metastasis of TC by targeting miR-599. Hsa_circ_0000285/miR-599 may be utilized as potential therapeutic targets in TC. 3 Downregulation of hsa_circ_0005243 induces trophoblast cell dysfunction and inflammation via the beta-catenin and NF-kappaB pathways. hsa_circ_0005243 hsa_circ_TMEM184B - DOID:9351 diabetes mellitus diabetes "RT-qPCR, RNA-seq" down-regulated "Downregulation of hsa_circ_0005243 may be associated with the pathogenesis of GDM via the regulation of beta-catenin and NF-kappaB signal pathways, suggesting a new potential therapeutic target for GDM." 2 "Circular RNA circTUBGCP3 Is Up-Regulated and Promotes Cell Proliferation, Migration and Survivability via Sponge _mir-30b in Osteosarcoma." - hsa_circ_TUBGCP3 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "The data indicate that circTUBGCP3 may act as a sponge of miR-30b that further alters the expression of Vimentin, and promotes the proliferation and metastatic properties of OS cells. " 2 "Hsa_circ_0043265 Suppresses Proliferation, Metastasis, EMT and Promotes Apoptosis in Non-Small Cell Lung Cancer Through miR-25-3p/FOXP2 Pathway." hsa_circ_0043265 hsa_circ_ACACA - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "Hsa_circ_0043265 could sponge miR-25-3p to improve FOXP2 expression, thereby inhibiting NSCLC progression. This study showed that hsa_circ_0043265 could be a potential biomarker for early diagnosis of NSCLC." 3 Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models. - hsa_circ_SCMH1 - DOID:2316 brain ischemia acute ischemic stroke RT-qPCR dysregulated Rabies virus glycoprotein-circSCMH1-extracellular vesicles afford protection by promoting functional recovery in the rodent and the nonhuman primate ischemic stroke models. 1 Circ-RNF111 contributes to paclitaxel resistance in breast cancer by elevating E2F3 expression via miR-140-5p. - hsa_circ_RNF111 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ-RNF111 improved PTX resistance of BC by upregulating E2F3 via sponging miR-140-5p. 2 The up-regulated hsa-circRNA9102-5 may be a risk factor for essential hypertension. - - hsa-circRNA9102-5 DOID:10825 essential hypertension essential hypertension "RT-qPCR, microarray" up-regulated "The present results suggested that hsa-circRNA9102-5 may have played a crucial role in the development of EH by sponging hsa-miR-150-5p, which showed great potential as a novel target." 1 The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway. - mmu_circ_TLK1 - DOID:936 brain disease ischemia reperfusion injury RT-qPCR up-regulated The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway. 1 CircFOXO3 functions as a molecular sponge for miR-143-3p to promote the progression of gastric carcinoma via upregulating USP44. hsa_circ_0006404 hsa_circ_FOXO3 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircFOXO3 functions as a molecular sponge for miR-143-3p to promote the progression of gastric carcinoma via upregulating USP44. 1 Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA-296-5p/CXCL10 axis. hsa_circ_0000515 hsa_circ_RPPH1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA-296-5p/CXCL10 axis. 9 Circular RNA hsa_circ_0085131 is involved in cisplatin-resistance of non-small-cell lung cancer cells by regulating autophagy. hsa_circ_0085131 hsa_circ_PABPC1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "hsa_circ_0085131 enhances DDP-resistance of NSCLC cells through sequestering miR-654-5p to upregulate ATG7, leading to cell autophagy." 1 Circular RNA circHIPK3 modulates the proliferation of airway smooth muscle cells by miR-326/STIM1 axis. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:2841 asthma asthma RT-qPCR up-regulated "circHIPK3 functions as a regulator in the airway remodeling during the asthma development through miR-326/STIM1 axis, providing a novel insight for the therapeutic target." 1 Knockdown of circHomer1 ameliorates METH-induced neuronal injury through inhibiting Bbc3 expression. - mmu_circ_Homer1 - DOID:231 motor neuron disease neuronal injury RT-qPCR up-regulated Knockdown of circHomer1 ameliorates METH-induced neuronal injury through inhibiting Bbc3 expression. 1 Circular RNA circ_0000615 knockdown suppresses the development of nasopharyngeal cancer through regulating the miR-338-3p/FGF2 axis. hsa_circ_0000615 hsa_circ_ZNF609 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "Circ_0000615 knockdown suppressed the growth of NPC cells via modulating miR-338-3p/FGF2 axis, providing a theoretical basis for the treatment of NPC." 5 Circular RNA circNRIP1 promotes migration and invasion in cervical cancer by sponging miR-629-3p and regulating the PTP4A1/ERK1/2 pathway. hsa_circ_0004771 hsa_circ_NRIP1 - DOID:4362 cervical cancer cervical cancer "RT-qPCR, microarray" up-regulated Circular RNA circNRIP1 promotes migration and invasion in cervical cancer by sponging miR-629-3p and regulating the PTP4A1/ERK1/2 pathway. 1 Circular RNA circKIF4A Sponges miR-375/1231 to Promote Bladder Cancer Progression by Upregulating NOTCH2 Expression. hsa_circ_0007255 hsa_circ_KIF4A - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated circKIF4A sponges miR-375/1231 to promote bladder cancer progression by upregulating NOTCH2. 1 Circ_0008532 promotes bladder cancer progression by regulation of the miR-155-5p/miR-330-5p/MTGR1 axis. hsa_circ_0008532 hsa_circ_CBFA2T2 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Circ_0008532 may act as an oncogene in BC through a novel circ_0008532/miR-155-5p, miR-330-5p /MTGR1/Notch pathway axis, which in turn may provide potential biomarkers and a therapeutic target for the management of bladder cancer." 1 Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p. hsa_circ_0000376 hsa_circ_PRH1-PRR4 - DOID:1612 breast cancer breast cancer microarray down-regulated "A novel circular RNA, hsa_circ_0000376, was identified in breast cancer that may act as a sponge targeting miR-1285-3p expression which through its target genes, SMURF1, BTRC, and TP53, may further regulate tumorigenesis." 2 Circular RNA_0001742 has potential to predict advanced tumor stage and poor survival profiles in tongue squamous cell carcinoma management. hsa_circ_0001742 hsa_circ_SMO - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma RT-qPCR up-regulated Circ_0001742 serves as a potential biomarker for advanced tumor stage and poor survival in TSCC patients. 4 Circular RNA hsa_circ_0054537 sponges miR-130a-3p to promote the progression of renal cell carcinoma through regulating cMet pathway. hsa_circ_0054537 hsa_circ_PSME4 - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated circRNA hsa_circ_0054537 functioned as a competitive endogenous RNA to regulate cMet expression via sponging miR-130a-3p in renal cancer. 1 Circular RNA hsa_circ_0003141 promotes tumorigenesis of hepatocellular carcinoma via a miR-1827/UBAP2 axis. hsa_circ_0003141 hsa_circ_UBAP2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "hsa_circ_0003141 functions as an oncogene in HCC cells, and suggest that the hsa_circ_0003141/miR-1827/UBAP2 axis might represent a novel therapeutic option for the treatment of HCC." 4 Circular RNA circ-MAT2B facilitates glycolysis and growth of gastric cancer through regulating the miR-515-5p/HIF-1alpha axis. - hsa_circ_MAT2B - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circular RNA circ-MAT2B facilitates glycolysis and growth of gastric cancer through regulating the miR-515-5p/HIF-1alpha axis. 1 Knockdown of circular RNA circ-FARSA restricts colorectal cancer cell growth through regulation of miR-330-5p/LASP1 axis. - hsa_circ_FARSA - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Silencing of circ-FARSA restricted the growth of CRC through regulating the miR-330-5p/LASP1 axis, providing a novel regulatory mechanism for CRC tumorigenesis." 1 Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis. - hsa_circ_CORO1C - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "Knockdown of circCORO1C inhibited the proliferation, migration, invasion, and in vivo tumorigenesis of LSCC cells. Mechanistic studies revealed that circCORO1C competitively bound to let-7c-5p and prevented it from decreasing the level of PBX3, which promoted the epithelial-mesenchymal transition and finally facilitated the malignant progression of LSCC. " 2 Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells. - hsa_circ_SATB2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circSATB2 participated in the progression of NSCLC and was differentially expressed in lung cancer tissue and serumal exosomes. circSATB2 may be potential biomarker for the diagnosis of NSCLC. 2 Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a/b/c-3p to upregulate STAT3/Gli2. hsa_circ_0043800 hsa_circ_STAT3 - DOID:687 hepatoblastoma hepatoblastoma RT-qPCR up-regulated Gli2-induced circ_0043800 served as the ceRNA to promote HB by up-regulation of STAT3 and Gli2 at a miR-29a/b/c-3p dependent manner. 1 CircRNA_101237 promotes NSCLC progression via the miRNA-490-3p/MAPK1 axis. - - circRNA_101237 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "hsa_circRNA_101237 promoted the expression of MAPK1 via miRNA-490-3p sponge, thus affecting the NSCLC as an important onco-circRNA." 1 Elevated Levels of circRUNX1 in Colorectal Cancer Promote Cell Growth and Metastasis via miR-145-5p/IGF1 Signalling. - hsa_circ_RUNX1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circRUNX1 functions as a tumor promotor in CRC cells by targeting the miR-145-5p/IGF1 signaling pathway and may have potential use as a prognostic indicator and therapeutic target in CRC patients. 2 Circular RNA _CircPRMT5 Accelerates Proliferation and Invasion of Papillary Thyroid Cancer Through Regulation of miR-30c/E2F3 Axis. - hsa_circ_PRMT5 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated circPRMT5 acts as an oncogenic circRNA to promote PTC progression via regulating miR-30c/E2F3 axis. 1 Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A. - hsa_circ_LARP4 - DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated Circular RNA_LARP4 could suppress cell migration and invasion of PCa by upregulating FOXO3A. 1 Circ_0061140 promotes metastasis of bladder cancer through adsorbing microRNA-1236. hsa_circ_0061140 hsa_circ_C20orf11 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Circ_0061140 level was found remarkably elevated in BCa tissues, as well as in cell lines, which was closely relevant to the incidence of lymph node or distant metastasis of BCa patients. In addition, circ_0061140 may enhance the proliferation rate and invasion ability of BCa cells through the modulation of microRNA-1236." 1 Sevoflurane impedes the progression of glioma through modulating the circular RNA has_circ_0012129/miR-761/TGIF2 axis. hsa_circ_0012129 hsa_circ_B4GALT2 - DOID:0060108 brain glioma glioma RT-qPCR dysregulated Sevoflurane mediated the progression of glioma via regulating the circ_0012129/miR-761/TGIF2 axis. 2 "Circular RNA LPAR3 sponges microRNA-198 to facilitate esophageal cancer migration, invasion, and metastasis." - hsa_circ_LPAR3 - DOID:5041 esophageal cancer esophageal cancer "RT-qPCR, microarray" up-regulated "Circular RNA LPAR3 can regulate the miR-198-MET signal axis to promote the migration, invasion, and metastasis of esophageal cancer cells, which can thereby serve as a potential diagnostic and therapeutic target of esophageal cancer." 1 "Silencing circSLAMF6 represses cell glycolysis, migration, and invasion by regulating the miR-204-5p/MYH9 axis in gastric cancer under hypoxia." - hsa_circ_SLAMF6 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "CircSLAMF6 was involved in glycolysis, migration, and invasion by regulating the miR-204-5p/MYH9 axis in GC cells under hypoxia." 3 Circular RNA COL1A2 promotes angiogenesis via regulating miR-29b/VEGF axis in diabetic retinopathy. hsa_circ_0081108 hsa_circ_COL1A2 - DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR up-regulated "circCOL1A2 facilities angiogenesis during the pathological progression of DR via regulating miR-29b/VEGF axis, suggesting that targeting circCOL1A2 may be a potential treatment for DR." 4 CircTP53 promotes the proliferation of thyroid cancer via targeting miR-1233-3p/MDM2 axis. - hsa_circ_TP53 - DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated overexpressed circTP53 decreased the protein level of p53 via targeting miR-1233-3p/MDM2 axis and promoted cancer cell proliferation. 1 Circular RNA circ_0124644 exacerbates the ox-LDL-induced endothelial injury in human vascular endothelial cells through regulating PAPP-A by acting as a sponge of miR-149-5p. hsa_circ_0124644 hsa_circ_ROBO2 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Circular RNA circ_0124644 exacerbates the ox-LDL-induced endothelial injury in human vascular endothelial cells through regulating PAPP-A by acting as a sponge of miR-149-5p. 2 CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p. - hsa_circ_TLK1 - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated circTLK1 plays a critical role in RCC progression by sponging miR-136-5p to increase CBX4 expression. circTLK1 may act as a diagnostic biomarker and therapeutic target for RCC. 1 Circular RNA hsa_circ_0078607 suppresses ovarian cancer progression by regulating miR-518a-5p/Fas signaling pathway. hsa_circ_0078607 hsa_circ_SLC22A3 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "that circ_0078607 suppressed ovarian cancer progression by sponging oncogenic miR-518a-5p to induce Fas expression, which may provide new therapeutic approach for ovarian cancer." 4 CircRNA 001372 Reduces Inflammation in Propofol-Induced Neuroinflammation and Neural Apoptosis through PIK3CA/Akt/NF-kappaB by miRNA-148b-3p. - - circRNA001372 DOID:81177 neuronitis neurotoxicity and neuroinflammation RT-qPCR down-regulated CircRNA001372 suppresses propofol-induced neurotoxicity and neuroinflammation through PI3K/Akt/NF-kappaB signaling pathway in rat brain and neurocytes. MiRNA-148b-3p antagonizes the effects of circRNA001372. 1 Suppression of Circular RNA Hsa_circ_0109320 Attenuates Non-Small Cell Lung Cancer Progression via MiR-595/E2F7 Axis. hsa_circ_0109320 hsa_circ_ZNF91 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0109320/miR-595/E2F2 axis may exert a pivotal role in the pathological mechanism of NSCLC progression, and it has potential application in the future treatment of NSCLC." 2 CircRNA circ_POLA2 promotes lung cancer cell stemness via regulating the miR-326/GNB1 axis. hsa_circ_0022812 hsa_circ_POLA2 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "circ_POLA2 promotes lung cancer cell stemness and progression via regulating the miR-326/GNB1 axis, which might serve as a novel therapeutic target for lung cancer patients." 1 Circular RNA circSLC25A16 contributes to the glycolysis of non-small-cell lung cancer through epigenetic modification. hsa_circ_0018534 hsa_circ_SLC25A16 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated "the crucial function of circSLC25A16 on NSCLC glycolysis through miR-488-3p/HIF-1alpha/LDHA, suggesting the underlying pathogenesis for NSCLC and providing a therapeutic strategy for precise treatment." 1 "Increased AT(2)R expression is induced by AT(1)R autoantibody via two axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to promote VSMC migration." - hsa_circ_ErbB4 - DOID:178 vascular disease vascular disease microarray up-regulated "Increased AT(2)R expression is induced by AT(1)R autoantibody via two axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to promote VSMC migration." 1 Circular RNA circ-CSPP1 regulates CCNE2 to facilitate hepatocellular carcinoma cell growth via sponging miR-577. - hsa_circ_CSPP1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "circ-CSPP1 contributed to HCC progression by positively regulating CCNE2 via miR-577, thus established its potential as new a prognostic and therapeutic marker for HCC patients." 6 Circular RNA-9119 protects IL-1beta-treated chondrocytes from apoptosis in an osteoarthritis cell model by intercepting the microRNA-26a/PTEN axis. - - circRNA-9119 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" down-regulated "CircRNA-9119 is an important regulator of IL-1beta-treated chondrocytes through the miR-26a/PTEN axis, possibly contributing to OA development." 1 Circular RNA (circRNA) CDYL Induces Myocardial Regeneration by ceRNA After Myocardial Infarction. - mmu_circ_CDYL - DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR down-regulated CircCDYL can promote the proliferation of cardiomyocytes through the miR-4793-5p/APP pathway. 1 Circ_0000517 Contributes to Hepatocellular Carcinoma Progression by Upregulating TXNDC5 via Sponging miR-1296-5p. hsa_circ_0000517 hsa_circ_RPPH1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ_0000517 accelerated HCC progression by upregulating TXNDC5 through sponging miR-1296-5p. 6 CircBPTF knockdown ameliorates high glucose-induced inflammatory injuries and oxidative stress by targeting the miR-384/LIN28B axis in human umbilical vein endothelial cells. - hsa_circ_BPTF CircBPTF DOID:4194 glucose metabolism disease high glucose-induced inflammatory injuries and oxidative stress RT-qPCR up-regulated CircBPTF knockdown protected against HG-induced inflammatory injuries and oxidative stress by mediating the miR-384/LIN28B axis in HUVECs 1 Circ_0072088 promotes the development of non-small cell lung cancer via the miR-377-5p/NOVA2 axis. hsa_circ_0072088 hsa_circ_ZFR - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0072088 facilitated the proliferation and metastasis of NSCLC cells through upregulating NOVA2 via functioning as a competitive endogenous RNA (ceRNA) for miR-377-5p. 3 The circRNA-MYLK plays oncogenic roles in the Hep-2 cell line by sponging microRNA-145-5p. - hsa_circ_MYLK - DOID:2600 laryngeal carcinoma laryngeal cancer RT-qPCR up-regulated circRNA-MYLK had oncogenic roles via targeting miR-145-5p in the Hep-2 cell line via stimulating MEK/ERK and NF-kappaB cascades. 1 circCYFIP2 Acts as a Sponge of miR-1205 and Affects the Expression of Its Target Gene E2F1 to Regulate Gastric Cancer Metastasis. hsa_circ_0003506 hsa_circ_CYFIP2 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "circCYFIP2 might serve as an oncogenic circRNA to promote GC progression via the miR-1205/E2F1 axis, which provided a potential therapeutic target for the treatment of GC." 2 circFMN2 Sponges miR-1238 to Promote the Expression of LIM-Homeobox Gene 2 in Prostate Cancer Cells. - hsa_circ_FMN2 - DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" down-regulated circFMN2 acts as a competing endogenous RNA (ceRNA) for miR-1238 to regulate LIM-homeobox gene 2 (LHX2) expression. circFMN2 regulates the miR-1238/LHX2 axis to promote PCa progression. 2 Circular RNA circUBAP2 regulates proliferation and invasion of osteosarcoma cells through miR-641/YAP1 axis. - hsa_circ_UBAP2 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Knockdown of circUBAP2 impeded proliferation and invasion of OS cells by downregulating the expression of YAP1 via sponging miR-641. 5 Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression. - hsa_circ_ZNF566 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "High circZNF566 expression in HCC tissues was positively correlated with clinicopathological features and poor prognosis. Functionally, in vitro experiments showed that circZNF566 promoted HCC cell migration, invasion, and proliferation, whereas in vivo experiments showed that circZNF566 promoted tumorigenesis and metastasis. " 1 Circular RNA-hsa-circ-0000670 promotes gastric cancer progression through the microRNA-384/SIX4 axis. hsa_circ_0000670 hsa_circ_C16orf72 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated Circular RNA-hsa-circ-0000670 promotes gastric cancer progression through the microRNA-384/SIX4 axis. 2 "Knockdown of circ_0003340 induces cell apoptosis, inhibits invasion and proliferation through miR-564/TPX2 in esophageal cancer cells." hsa_circ_0003340 hsa_circ_OGDH - DOID:5041 esophageal cancer esophageal cancer RT-qPCR down-regulated "Knockdown of circ_0003340 induces cell apoptosis, inhibits invasion and proliferation through miR-564/TPX2 in esophageal cancer cells." 3 "[Circular RNA-UBXN7 promotes proliferation, migration and suppresses apoptosis in hepatocellular cancer]." - hsa_circ_UBXN7 - DOID:684 hepatocellular carcinoma hepatocellular cancer RT-qPCR up-regulated "circ_UBXN7 plays an important role in promoting the occurrence and development of liver cancer, and is expected to become a potential target for the treatment of liver cancer." 1 Hsa_circ_0003732 promotes osteosarcoma cells proliferation via miR-545/CCNA2 axis. hsa_circ_0003732 hsa_circ_HUWE1 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated hsa_circ_0003732 promotes OS cells proliferation via miR-545/CCNA2 axis and imply hsa_circ_0003732 may be a potential prognosis biomarker and therapeutic target for OS. 2 Circular RNA FUNDC1 improves prediction of stroke associated infection in acute ischemic stroke patients with high risk. hsa_circ_0007290 hsa_circ_FUNDC1 - DOID:2316 brain ischemia acute ischemic stroke RT-qPCR up-regulated circFUNDC1 could be used to construct a risk model for the prediction of SAI that is beneficial for AIS patients preventive treatment. 2 circPUM1 promotes polycystic ovary syndrome progression by sponging to miR-760. hsa_circ_0000043 hsa_circ_PUM1 - DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RT-qPCR up-regulated circPUM1 promotes PCOS progression through sponging to miR-760. We may provide a promising therapeutic target for PCOS. 1 Circular RNA Gprc5a Promotes HCC Progression by Activating YAP1/TEAD1 Signalling Pathway by Sponging miR-1283. - hsa_circ_Gprc5a - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Knockout of circGprc5a inhibited proliferation of HCC and induced apoptosis. CircGprc5a activated the YAP1/TEAD1 signaling pathway by acting as a sponge for miR-1283. Furthermore, overexpression of miR-1283 abolished the promotion of circGprc5a on HCC cells. " 1 CircHIPK3 Facilitates the G2/M Transition in Prostate Cancer Cells by Sponging miR-338-3p. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated CircHIPK3 promotes G2/M transition and induces PCa cell proliferation by sponging miR-338-3p and increasing the expression of Cdc25B and Cdc2. CircHIPK3 may play an oncogenic role in PCa. 4 Circular RNA hsa_circ_0131242 Promotes Triple-Negative Breast Cancer Progression by Sponging hsa-miR-2682. hsa_circ_0131242 hsa_circ_MAP3K4 - DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, microarray" up-regulated Our study identified hsa_circ_0131242 expression in TNBC for the first time and found that hsa_circ_0131242 may promote triple-negative breast cancer progression by sponging hsa-miR-2682. 1 Upregulation of hsa_circRNA_102958 Indicates Poor Prognosis and Promotes Ovarian Cancer Progression Through miR-1205/SH2D3A Axis. - - hsa_circ_102958 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Knockdown of hsa_circRNA_102958 significantly suppressed the proliferation, migration and invasion of OC cells and vice versa. hsa_circRNA_102958 was a competing endogenous RNA (ceRNA) for miR-1205. hsa_circRNA_102958 inhibited miR-1205 activity to promote SH2D3A expression. Overexpression of SH2D3A promoted proliferation, migration and invasion of OC cells." 1 Circ-APBB1IP as a Prognostic Biomarker Promotes Clear Cell Renal Cell Carcinoma Progression Through The ERK1/2 Signaling Pathway. - hsa_circ_APBB1IP - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, microarray" up-regulated "knockdown of circ-APBB1IP by siRNA suppressed the proliferation, migration, and invasion and increased the apoptosis of ccRCC cells. Further study found that knockdown of circ-APBB1IP up-regulated protein expression of cleaved caspase-3, cleaved caspase-7, cleaved caspase-8, cleaved caspase-9, Bax, Bad, Bak, E-cadherin and down-regulated expression of Bcl-2, N-cadherin, MMP-2, MMP-9, p-ERK1/2. " 1 Upregulated Circular RNA hsa_circ_0008433 Regulates Pathogenesis in Endometriosis Via miRNA. hsa_circ_0008433 hsa_circ_PDE4B - DOID:288 endometriosis of uterus endometriosis "RT-qPCR, RNA-seq" up-regulated "The hsa_circ_0008433 knockdown inhibited endometrial stromal cell proliferation, migration, colony formation, and angiopoiesis; promoted cell apoptosis; and downregulated Ki67 and PCNA expression levels. Moreover, the hsa_circ_0008433 knockdown increased Bax and E-CAD expression and decreased Bcl2, CDKN1B, and CyclinD1 levels." 1 Circ_LDLR promoted the development of papillary thyroid carcinoma via regulating miR-195-5p/LIPH axis. - hsa_circ_LDLR - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "Silencing of circ_LDLR suppressed PTC cell colony formation, proliferation, migration and invasion and promoted apoptosis in vitro and hampered tumor growth in vivo." 3 "Matrine inhibits cell growth, migration, invasion and promotes autophagy in hepatocellular carcinoma by regulation of circ_0027345/miR-345-5p/HOXD3 axis." hsa_circ_0027345 hsa_circ_LRIG3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Matrine inhibited cell development and tumorigenesis in HCC by increasing miR-345-5p and decreasing circ_0027345 and HOXD3. 3 Circular RNA circ_0000284 plays an oncogenic role in the progression of non-small cell lung cancer through the miR-377-3p-mediated PD-L1 promotion. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0000284 facilitated the progression of NSCLC by up-regulating the PD-L1 expression as a competing endogenous RNA (ceRNA) of miR-377, possibly developing a different perspective in understanding the molecular pathogenesis of NSCLC." 4 Hsa_Circ_0007841 Enhances Multiple Myeloma Chemotherapy Resistance Through Upregulating ABCG2. hsa_circ_0007841 hsa_circ_SEC61A1 - DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated Our data collectively suggest a new model in which hsa_circ_0007841 promotes acquired chemotherapy resistance by upregulating ATP-binding cassette transporters G2 providing a novel molecular basis of chemotherapy in multiple myeloma cancer. 5 Genome-wide profiling of host-encoded circular RNAs highlights their potential role during the Japanese encephalitis virus-induced neuroinflammatory response. hsa_circ_0000220 - circ_0000220 DOID:10844 Japanese encephalitis Japanese encephalitis "RT-qPCR, RNA-seq" up-regulated The knockdown of circ_0000220 or overexpression of miR-326-3p caused a lower production of JEV-induced inflammatory cytokines 1 Hsa_circ_0003998 promotes epithelial to mesenchymal transition of hepatocellular carcinoma by sponging miR-143-3p and PCBP1. hsa_circ_0003998 hsa_circ_ARFGEF2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated Circ0003998 promotes EMT of HCC by circ0003998/miR-143-3p/FOSL2 axis and circ0003998 /PCBP1/CD44v6 axis. 3 Circular RNA circ_0003645 silencing alleviates inflammation and apoptosis via the NF-kappaB pathway in endothelial cells induced by oxLDL. hsa_circ_0003645 hsa_circ_C16orf62 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "circ_0003645 silencing alleviated inflammation and apoptosis, while promoted the viability in oxLDL-induced endothelial cells by the NF-kappaB pathway." 3 Silencing of hsa_circ_0101145 reverses the epithelial-mesenchymal transition in hepatocellular carcinoma via regulation of the miR-548c-3p/LAMC2 axis. hsa_circ_0101145 - - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0101145 silencing suppressed HCC progression by functioning as an miR-548c-3p sponge to enhance LAMC2 expression. Therefore, hsa_circ_0101145 could be an HCC treatment target." 1 Overexpressed circ-RPL15 predicts poor survival and promotes the progression of gastric cancer via regulating miR-502-3p/OLFM4/STAT3 pathway. hsa_circ_0064574 hsa_circ_RPL15 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circ-RPL15 promotes GC progression and predicts poor prognosis of GC patients, and regulates the malignant phenotypes of GC cells by mediating the miR-502-3p/OLFM4/STAT3 axis." 1 High expression of circulating exosomal circAKT3 is associated with higher recurrence in HCC patients undergoing surgical treatment. - hsa_circ_AKT3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated high circulating exosomal circAKT3 is associated with a higher risk of HCC recurrence and mortality. Follow-up of HCC patients with high exosomal circAKT3 after surgery may help to reduce the risk of recurrence and improve prognosis. 1 Circular RNA circ_0001105 protects the intestinal barrier of septic rats by inhibiting inflammation and oxidative damage and YAP1 expression. hsa_circ_0001105 - circ_0001105 DOID:0040085 bacterial sepsis sepsis RT-qPCR up-regulated "circ_0001105 protects the intestinal barrier function of septic rats by inhibiting intestinal inflammation, oxidative damage and YAP1 expression. Our results provide a novel insight for developing sepsis treatment." 1 "Hsa_circ_0023642 promotes proliferation, invasion, and migration of gastric cancer by sponging microRNA-223." hsa_circ_0023642 hsa_circ_UVRAG - DOID:10534 stomach cancer gastric cancer microarray up-regulated "This study shows that the upregulation of hsa_circ_0023642 affects the malignant progression, clinical stage, and prognosis of GC which provides a new molecular target for the therapy of GC." 2 Hsa_circ_0038646 promotes cell proliferation and migration in colorectal cancer via miR-331-3p/GRIK3. hsa_circ_0038646 hsa_circ_PRKCB - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated hsa_circ_0038646 functions as a tumor promoter in CRC by increasing GRIK3 expression via sponging of miR-331-3p. The hsa_circ_0038646/miR-331-3p/GRIK3 axis may be a novel therapeutic and diagnostic target of CRC. 1 CircABCB10 silencing inhibits the cell ferroptosis and apoptosis by regulating the miR-326/CCL5 axis in rectal cancer. - hsa_circ_ABCB10 - DOID:1993 rectum cancer rectal cancer RT-qPCR up-regulated CircABCB10 silencing inhibits the cell ferroptosis and apoptosis by regulating the miR-326/CCL5 axis in rectal cancer. 1 CircABCB10 promotes the proliferation and migration of lung cancer cells through down-regulating microRNA-217 expression. - hsa_circ_ABCB10 - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "In vitro cell experiments demonstrated that knocking down circABCB10 remarkably suppressed the proliferation and migration ability of LCa cells. In addition, circABCB10 can specifically bind to microRNA-217 and negatively regulate its expression of microRNA-217 in LCa cells. Finally, cell functional experiments showed that microRNA-217 is a key downstream gene that mediates the regulation of circABCB10 on LCa cell function." 1 Circular RNA hsa_circ_103809 promotes cell migration and invasion of gastric cancer cells by binding to microRNA-101-3p. - - hsa_circ_103809 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Hsa_circ_103809, highly expressed in GCa, may promote the migration capacity of GCa cells by adsorbing microRNA-101-3p and thus become a new therapeutic target for GCa." 1 Circ-100338 induces angiogenesis after myocardial ischemia-reperfusion injury by sponging miR-200a-3p. - - hsa_circ_100338 DOID:936 brain disease ischemia reperfusion injury RT-qPCR down-regulated "CircRNA-100338 may inhibit the function of miRNA-200a-3p by combining with miRNA-200a-3p, and then miRNA-200a-3p plays a role in regulating FUS, thereby regulating the state of angiogenesis." 1 Circ_0074027 Contributes to Non-Small Cell Lung Cancer Progression by Upregulating CUL4B Expression Through miR-335-5p. hsa_circ_0074027 hsa_circ_PITX1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0074027 facilitated NSCLC cell progression through regulating miR-335-5p/CUL4B axis. 3 CircRNA-PTN Sponges miR-326 to Promote Proliferation in Hepatocellular Carcinoma. hsa_circ_0003949 hsa_circ_PTN - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circPTN acted as a sponge through interacting with miR-326. Overexpression of miR-326 could rescue the cell proliferation inhibition and ErbB/PI3K downregulation in HCC cells by circPTN. Besides, the effects of miR-326 on HCC were missing when circPTN binding sites were mutated." 1 CircRNA DONSON contributes to cisplatin resistance in gastric cancer cells by regulating miR-802/BMI1 axis. - hsa_circ_DONSON - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "circDONSON promoted cisplatin resistance in gastric cancer cells by regulating miR-802/BMI1 axis, shedding light on the development of a novel therapeutic strategy to overcome chemoresistance in gastric cancer patients." 3 Circular RNA DOCK1 downregulates microRNA-124 to induce the growth of human thyroid cancer cell lines. - hsa_circ_DOCK1 - DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated circDOCK1 contributed to thyroid carcinogenesis through inhibition of miR-124 in thyroid cancer cells with dampening signaling transduction of JAK/STAT/AMPK in virtue of miR-124 downregulation. 1 hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis. hsa_circ_0004018 hsa_circ_SMYD4 - DOID:409 liver disease liver fibrosis RT-qPCR up-regulated hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis. 1 Circular RNA circ_0111277 attenuates human trophoblast cell invasion and migration by regulating miR-494/HTRA1/Notch-1 signal pathway in pre-eclampsia. hsa_circ_0111277 hsa_circ_PAPPA2 - DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated "trophoblast cell migration and invasion were shown to be promoted and modulated by the hsa_circ_0111277/miR-494-3p/HTRA1/Notch-1 axis, which provides useful insight for exploring a new therapeutic approach for PE." 1 Hsa_circ_0009910: oncogenic circular RNA targets microRNA-145 in ovarian cancer cells. hsa_circ_0009910 hsa_circ_MFN2 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Hsa_circ_0009910, representing unfavorable prognosis, induced proliferative and motile phenotypes by suppressing miR-145 in ovarian cancer cells." 2 Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma. - hsa_circ_UHRF1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Exosomal circUHRF1 is predominantly secreted by HCC cells and contributes to immunosuppression by inducing NK cell dysfunction in HCC. CircUHRF1 may drive resistance to anti-PD1 immunotherapy, providing a potential therapeutic strategy for patients with HCC." 2 circ_0080145 Enhances Imatinib Resistance of Chronic Myeloid Leukemia by Regulating miR-326/PPFIA1 Axis. hsa_circ_0080145 hsa_circ_TNS3 - DOID:8552 chronic myeloid leukemia chronic myeloid leukemia RT-qPCR up-regulated "circ_0080145 contributes to IM resistance via modulating miR-326/PPFIA1 axis, which might provide a novel avenue for CML therapy." 3 Circular RNA TUBA1C accelerates the progression of non-small-cell lung cancer by sponging miR-143-3p. hsa_circ_0026134 hsa_circ_TUBA1C - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "the decline of tumor growth resulted from circTUBA1C deficiency could be recovered by miR-143-3p knockdown. Taken together, these findings indicated the important role of circTUBA1C/miR-143-3p axis in NSCLC, which may provide a potential target for NSCLC therapy." 3 Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation. hsa_circ_0000936 hsa_circ_SHKBP1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated "exosomal circSHKBP1 regulates the miR-582-3p/HUR/VEGF pathway, suppresses HSP90 degradation, and promotes GC progression. circSHKBP1 is a promising circulating biomarker for GC diagnosis and prognosis and an exceptional candidate for further therapeutic exploration." 1 SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway. hsa_circ_0075686 hsa_circ_ATXN1 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated SRSF10/circ-ATXN1/miR-526b-3p axis played a crucial role in regulating the angiogenesis of GECs. The above findings provided new targets for anti-angiogenic therapy in glioma. 1 circ_0007385 served as competing endogenous RNA for miR-519d-3p to suppress malignant behaviors and cisplatin resistance of non-small cell lung cancer cells. hsa_circ_0007385 hsa_circ_MEMO1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ_0007385 was upregulated in NSCLC tissues and cells, and was associated with poor overall survival. Silenced circ_0007385 suppressed NSCLC cell proliferation, migration, invasion, and DDP resistance in vitro, and tumor growth in vivo. circ_0007385 was upregulated in NSCLC tissues and cells, and was associated with poor overall survival." 5 Elevation in the Expression of circ_0079586 Predicts Poor Prognosis and Accelerates Progression in Glioma via Interactions with the miR-183-5p/MDM4 Signaling Pathway. hsa_circ_0079586 hsa_circ_IGF2BP3 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circ_0079586 was found to be up-regulated in GM that increased the proliferation, migration and invasion in GM cells via interaction with the miR-183-5p/MDM4 axis. We anticipate that our study would provide newer insights into the mechanism and treatment of GM." 2 CircNOL10 Acts as a Sponge of miR-135a/b-5p in Suppressing Colorectal Cancer Progression via Regulating KLF9. - hsa_circ_NOL10 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "circNOL10 impeded CRC development by mediating proliferation, cell cycle, migration, and invasion by sponging miR-135a-5p and miR-135b-5p, which provided new understanding for CRC treatment." 1 A Novel Serum Exosomes-Based Biomarker hsa_circ_0002130 Facilitates Osimertinib-Resistance in Non-Small Cell Lung Cancer by Sponging miR-498. hsa_circ_0002130 hsa_circ_C3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated A Novel Serum Exosomes-Based Biomarker hsa_circ_0002130 Facilitates Osimertinib-Resistance in Non-Small Cell Lung Cancer by Sponging miR-498. 1 Diagnostic Role of Dysregulated Circular RNA hsa_circ_0036722 in Laryngeal Squamous Cell Carcinoma. hsa_circ_0036722 hsa_circ_RHCG - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR down-regulated "hsa_circ_0036722 was downregulated in LSCC, which regulate the function of RHCG in LSCC via inhibiting miR-1248, and it could serve as a potential diagnostic marker for LSCC." 1 Circ-PRKDC Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells by Regulating miR-375/FOXM1 Axis and Wnt/beta-Catenin Pathway. - hsa_circ_PRKDC - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ-PRKDC enhanced 5-FU resistance in CRC by regulating FOXM1/miR-375 axis and wnt/beta-catenin pathway. 4 The Regulatory Role of circRNA_101308 in Cervical Cancer and the Prediction of Its Mechanism. - - hsa_circ_101308 DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated CircRNA_101308 is downregulated and acts as a tumor suppressor in CC. CircRNA_101308 can participate in many different processes by sponging different miRNAs in CC cells. This exploration of circRNA_101308 provides new directions for research on cancer development and the clinical treatment of CC. 1 CircHN1 affects cell proliferation and migration in gastric cancer. - hsa_circ_HN1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated CircHN1 is aberrantly expressed in GC and affects the proliferation and migration of gastric cancer cells by acting as miRNA sponge. 4 Circular RNA FOXO3 Suppresses Bladder Cancer Progression and Metastasis by Regulating MiR-9-5p/TGFBR2. - hsa_circ_FOXO3 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "circ-FOXO3 was significantly down-regulated in bladder cancers. circ-FOXO3 overexpression inhibits BC cell progression and metastasis. Furthermore, circ-FOXO3 regulates TGFBR2 expression through sponging miR-9-5p in BC cell lines." 2 Circular RNA La-Related Protein 4 Inhibits Non-Small Cell Lung Cancer Cell Proliferation While Promotes Apoptosis Through Sponging microRNA-21-5p. - hsa_circ_LARP4 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated Circ-LARP4 is decreased and suppresses cell proliferation while promoted apoptosis by sponging miR-21-5p in NSCLC. 4 "circMET promotes NSCLC cell proliferation, metastasis, and immune evasion by regulating the miR-145-5p/CXCL3 axis." hsa_circ_0082003 hsa_circ_MET - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circMET acts as a miR-145-5p sponge to upregulate CXCL3 expression. Collectively, circMET regulates the miR-145-5p/CXCL3 axis and serves as a novel, promising diagnostic and prognostic biomarker in patients with NSCLC." 1 Circular RNA circ_0011269 sponges miR-122 to regulate RUNX2 expression and promotes osteoporosis progression. hsa_circ_0011269 hsa_circ_ZCCHC17 - DOID:11476 osteoporosis osteoporosis "RT-qPCR, microarray" down-regulated circ_0011269 sponges miR-122 to regulate RUNX2 expression and promotes osteoporosis progression. 1 "Down-regulation of circ_0061140 attenuates ectopic endometrial cell proliferation, migration and invasion in endometriosis via inactivating Notch2." hsa_circ_0061140 hsa_circ_C20orf11 - DOID:288 endometriosis of uterus endometriosis RT-qPCR up-regulated Decrease of circ_0061140 could depress endometriosis progression through modulating miR-140-3p and Notch2. 2 Circular RNA Expression Profiles and the Pro-tumorigenic Function of CircRNA_10156 in Hepatitis B Virus-Related Liver Cancer. - - circRNA_10156 DOID:3571 liver cancer liver cancer "RT-qPCR, RNA-seq" up-regulated "depletion of circRNA_10156 upregulated miR-149-3p, reduced Akt1 expression, and suppressed liver cancer cell proliferation." 1 RNA-Seq Profiling of Serum Exosomal Circular RNAs Reveals Circ-PNN as a Potential Biomarker for Human Colorectal Cancer. hsa_circ_0101802 hsa_circ_PNN - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "the expression of hsa-miR-6833-3P, hsa-let-7i-3p and hsa-miR-1301-3P were negatively correlated with circ-PNN in CRC patients. Collectively, our findings indicated that serum exosomal circ-PNN might be a potential non-invasive biomarker for the detection of CRC and may play a crucial role in the pathogenesis of CRC." 3 Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR_185_5p and matrix metalloproteinase 2. - hsa_circ_TIMP2 - DOID:90 degenerative disc disease intervertebral disc degeneration RT-qPCR down-regulated circ_TIMP2 promoted TNF_alpha_ and IL_1beta_induced NP cell imbalance between ECM anabolism and catabolism via miR_185_5p_MMP2 signaling. 1 CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR_1236_3p in cutaneous squamous cell carcinoma. hsa_circ_0070934 hsa_circ_LARP1B - DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma "RT-qPCR, microarray" up-regulated the effects of the circ_0070934/miR_1236_3p/HOXB7 regulatory axis on CSCC and provided a novel insight for the pathogenesis of CSCC. 5 circPAN3 exerts a profibrotic role via sponging miR-221 through FoxO3/ATG7-activated autophagy in a rat model of myocardial infarction. - rno_circ_PAN3 - DOID:1287 cardiovascular system disease cardiovascular disease RT-qPCR up-regulated "circPAN3 exhibited profibrotic effects during autophagy-mediated cardiac fibrosis via miR-221/FoxO3/ATG7 axis, which may serve as potential biomarkers for cardiac fibrosis therapeutics." 1 Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/beta-catenin signalling pathway. - hsa_circ_FGD4 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated circFGD4 suppressed GC progression through sponging miR-532-3p and enhancing APC expression to inactivate the beta-catenin signalling. Thus circFGD4 provides a novel potential biomarker and valuable therapeutic strategy for GC. 1 CircVCAN regulates the proliferation and apoptosis of osteoarthritis chondrocyte through NF-kappaB signaling pathway. - hsa_circ_VCAN - DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "CircVCAN is overexpressed in OA tissues and cells. CircVCAN can affect the proliferation and apoptosis of OA chondrocytes by blocking the activation of the NF-kappaB signaling pathway. Thus, CircVCAN may be an important target molecule for OA treatment." 1 Circle RNA FOXP1 promotes cell proliferation in lung cancer by regulating miR-185-5p/Wnt1 signaling pathway. hsa_circ_0008234 hsa_circ_FOXP1 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated circFOXP1 promoted cell proliferation and repressed cell apoptosis in LUAD by regulating miR-185-5p/WNT1 signaling pathway. It provides a novel potential therapeutic agent for the treatment of LUAD. 1 CircDDX17 acts as a competing endogenous RNA for miR-605 in breast cancer progression. - hsa_circ_DDX17 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "We identified the downregulation of circDDX17 in breast cancer, and circDDX17 acted as a tumour suppressor by inhibiting proliferation and promoting apoptosis through its function as a sponge of miR-605 in breast cancer, indicating that it serves as a potential biomarker and a therapeutic target for breast cancer." 1 Circ-ABCB10 acts as an oncogene in glioma cells via regulation of the miR-620/FABP5 axis. - hsa_circ_ABCB10 - DOID:0060108 brain glioma glioma RT-qPCR down-regulated "circ-ABCB10 affects glioma progression by regulating the miR-620/FABP5 axis, and circ-ABCB10 might be used as a potential target for the treatment of glioma." 1 "A Novel Circular RNA, circ_0005394, Predicts Unfavorable Prognosis and Contributes to Hepatocellular Carcinoma Progression by Regulating miR-507/E2F3 and miR-515-5p/CXCL6 Signaling Pathways." hsa_circ_0005394 hsa_circ_ZC3H7A - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Rescue assay indicated that circ_0005394 facilitated HCC growth and invasion by regulating miR-507/E2F3 and miR-515-5p/CXCL6 signaling pathways. This study uncovered an important role of circ_0005394 in regulating HCC progression, providing a novel perspective for clarifying its pathogenesis." 1 Down-Regulation of circNRIP1 Promotes the Apoptosis and Inhibits the Migration and Invasion of Gastric Cancer Cells by miR-182/ROCK1 Axis. - hsa_circ_NRIP1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Silence of circNRIP1 inhibited progression of gastric cancer by increasing miR-182 and decreasing ROCK1, providing a novel target for the treatment of gastric cancer." 6 circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1alpha pathway. - - circRNA_100859 DOID:219 colon cancer colon cancer "RT-qPCR, microarray" up-regulated the circRNA_100859-miR-217-HIF-1alpha axis may serve as a novel diagnostic and prognostic biomarker for patients with colon cancer. 1 Exosomal circ-HIPK3 Facilitates Tumor Progression and Temozolomide Resistance by Regulating miR-421/ZIC5 Axis in Glioma. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:0060108 brain glioma glioma RT-qPCR down-regulated Exosomal circ-HIPK3 could promote cell progression and TMZ resistance by regulating miR-421/ZIC5 axis in TMZ-resistant glioma. 7 Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis. hsa_circ_0007334 hsa_circ_MBOAT2 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "circMBOAT2 overexpression upregulated the expression of mTOR by acting as a decoy for miR-1271-5p, resulting in the activation of the PI3K/Akt pathway, ultimately promoting the progression of PCa. Importantly, application of an inhibitor of mTOR significantly antagonized circMBOAT2-mediated PCa tumorigenesis in vivo. circMBOAT2 promotes proliferation and metastasis of PCa through miR-1271-5p/mTOR axis-mediated activation of the PI3K/Akt pathway." 1 Circular RNA circDLGAP4 is involved in lung cancer development through modulating microRNA-143/CDK1 axis. - hsa_circ_DLGAP4 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated circular RNA circDLGAP4 is involved in lung cancer development through modulating microRNA-143/CDK1 axis. circDLGAP4 may serve as a potential biomarker for the diagnosis or treatment of lung cancer. 1 Hsa_circ_0026134 expression promoted TRIM25- and IGF2BP3-mediated hepatocellular carcinoma cell proliferation and invasion via sponging miR-127-5p. hsa_circ_0026134 hsa_circ_TUBA1C - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Down-regulation of hsa_circ_0026134 suppressed TRIM25- and IGF2BP3-mediated HCC cell proliferation and invasion via promotion of miR-127-5p expression, which have been confirmed by luciferase reporter assay. " 2 The circular RNA circEIF3M promotes breast cancer progression by promoting cyclin D1 expression. hsa_circ_0003119 hsa_circ_EIF3M - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated circEIF3M promotes triple-negative breast cancer progression via the circEIF3M/ miR-33a/ cyclin D1 axis. 1 Circular RNA circNTRK2 facilitates the progression of esophageal squamous cell carcinoma through up-regulating NRIP1 expression via miR-140-3p. - hsa_circ_NTRK2 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated CircNTRK2 promoted ESCC progression by regulating miR-140-3p/NRIP1 pathway. Our findings contribute to a better understanding of circRNAs as miRNA sponges and highlight a promising therapy target in ESCC. 2 circ_KIAA1429 accelerates hepatocellular carcinoma advancement through the mechanism of m(6)A-YTHDF3-Zeb1. hsa_circ_0084922 hsa_circ_KIAA1429 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circ_KIAA1429 could accelerate HCC advancement, maintained the expression of Zeb1 through the mechanism of m(6)A-YTHDF3-Zeb1 in HCC." 2 CircMMP11 acts as a ce-circRNA in breast cancer progression by regulating miR-1204. - hsa_circ_MMP11 - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated The circMMP11/miR-1204/MMP11 axis regulates breast cancer progression via a competitive endogenous RNA (ceRNA) mechanism. CircMMP11 may serve as a potential therapeutic target in BC. 4 Circular RNA circ-LDLRAD3 serves as an oncogene to promote non-small cell lung cancer progression by upregulating SLC1A5 through sponging miR-137. - hsa_circ_LDLRAD3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated knock-down of circ-LDLRAD3 inhibited the development of NSCLC by regulating miR-137/SLC1A5 axis. 1 Circular RNA S-7 promotes ovarian cancer EMT via sponging miR-641 to up-regulate ZEB1 and MDM2. - - ciRS-7 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "CiRS-7 serves as a competing endogenous RNA of miR-641 that promoted cell growth and metastasis in OC, via regulating ZEB1 and MDM2-mediated EMT. High ciRS-7 expression was a poor prognosis of TNM stages, lymph node metastasis status and overall survival rate in OC patients. Targeting ciRS-7/miR-641/ZEB1 or ciRS-7/miR-641/MDM2 axis may be a novel diagnostic, prognostic and therapeutic strategy for OC." 1 circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression. - hsa_circ_NFATC3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated "both circNFATC3 and NFATC3 were shown to inhibit the phosphorylation of JNK, c-Jun, AKT, and mTOR signaling pathways. Overall, the circNFATC3 can sponge miR-548I to protect NFATC3 itself, then it regulates hepatoma cell function via the JNK, c-Jun, AKT, and mTOR signaling pathways, and the circNFATC3 can be a tumor-repressor on HCC." 1 Sevoflurane Regulates Glioma Progression by Circ_0002755/miR-628-5p/MAGT1 Axis. hsa_circ_0002755 hsa_circ_CLIP2 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "overexpression of circ_0002755 overturned Sev-mediated inhibitory effect on glioma progression. Further research indicated that circ_0002755 targeted miR-628-5p, and miR-628-5p targeted MAGT1, and Sev modulated glioma progression via circ_0002755/miR-628-5p/MAGT1 axis. Moreover, Sev hindered tumor growth in vivo." 3 Circular RNA Hsa_circ_0066755 as an Oncogene via sponging miR-651 and as a Promising Diagnostic Biomarker for Nasopharyngeal Carcinoma. hsa_circ_0066755 hsa_circ_KIAA1524 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "hsa_circ_0066755 played a role of oncogene in NPC and could be used as an effective diagnostic marker for NPC, and that hsa_circ_0066755 / miR-651 axis also involved in the progression of NPC." 1 Circular RNA hsa-circ-0007766 modulates the progression of Gastric Carcinoma via miR-1233-3p/GDF15 axis. hsa_circ_0007766 hsa_circ_ERBB2 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "This study unveils a mechanism by which hsa-circ-0007766 regulates GDF15 via hsa-circ-0007766/miR-1233-3p/GDF15 axis, which may provide new insight for GC therapeutic strategies." 2 Circ_0000527 promotes the progression of retinoblastoma by regulating miR-646/LRP6 axis. hsa_circ_0000527 hsa_circ_FAM158A - DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated Circ_0000527 enhances the proliferation and metastasis of RB cells by modulating the miR-646/LRP6 axis. 5 A Novel Circular RNA hsa_circRPPH1_015 Exerts an Oncogenic Role in Breast Cancer by Impairing miRNA-326-Mediated ELK1 Inhibition. - hsa_circ_RPPH1_015 hsa_circRPPH1_015 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "hsa_circRPPH1_015 could bind to miRNA-326 that negatively regulates ELK1. Elevation of miRNA-326 expression resulted in inhibition of cell proliferation, colony formation, and cell invasion of MCF-7. Disturbance of miRNA-326 or overexpression of ELK1 restored the proliferation and aggressiveness in hsa_circRPPH1_015-depleted MCF-7 cells. " 1 "Circular RNA circ_0091579 Promotes Hepatocellular Carcinoma Proliferation, Migration, Invasion, and Glycolysis Through miR-490-5p/CASC3 Axis." hsa_circ_0091579 - circ_0091579 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circ_0091579 promoted cell proliferation, migration, invasion, and glycolysis partially through miR-490-5p/CASC3 axis in HCC cells." 6 Hsa_circ_0088036 promotes the proliferation and migration of fibroblast-like synoviocytes by sponging miR-140-3p and upregulating SIRT 1 expression in rheumatoid arthritis. hsa_circ_0088036 hsa_circ_SUSD1 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "circ0088036 may play an essential role in promoting synovial pathogenesis via the circ0088036/miR-140-3p/SIRT 1 axis in RA, providing new insight into circRNAs during RA progression." 3 Circular RNA-9119 suppresses in ovarian cancer cell viability via targeting the microRNA-21-5p-PTEN-Akt pathway. - - circ9119 DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, microarray" up-regulated circ9119 could regulate cell proliferation and apoptosis of OC cells via by acting as an miR-21 sponge and targeting the PTEN-Akt pathway. 1 CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism. - hsa_circ_HECTD1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated circHECTD1 facilitates HCC progression by sponging miR-485-5p to up-regulate MUC1. 1 "Knockdown of Circ_0081143 Mitigates Hypoxia-Induced Migration, Invasion, and EMT in Gastric Cancer Cells Through the miR-497-5p/EGFR Axis." hsa_circ_0081143 - circ_0081143 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "The present work suggested that circ_0081143 knockdown ameliorated hypoxia-induced migration, invasion, and EMT in GC cells at least partly by the miR-497-5p/EGFR axis, illuminating a novel molecular target for GC treatment." 3 Circular RNA circVEGFC accelerates high glucose-induced vascular endothelial cells apoptosis through miR-338-3p/HIF-1alpha/VEGFA axis. - hsa_circ_VEGFC - DOID:9351 diabetes mellitus diabetes "RT-qPCR, microarray" up-regulated "the promotion of circVEGFC/miR-338-3p/HIF-1alpha/VEGFA axis in the HG-induced ECs apoptosis, providing a potential treatment strategy for ECs damage in DM." 1 CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1. - hsa_circ_AGFG1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circAGFG1 modulated YY1/CTNNB1 axis to drive metastasis and stemness in CRC by sponging miR-4262 and miR-185-5p. 1 Circular RNA HIPK3 regulates human lens epithelial cell dysfunction by targeting the miR-221-3p/PI3K/AKT pathway in age-related cataract. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:0070353 cataract age-related cataract RT-qPCR down-regulated "circHIPK3 protected HLECs from dysfunction by regulating miR-221-3p/PI3K/AKT pathway, indicating a new insight into the pathogenesis of ARC and providing a potential therapeutic target for ARC." 3 Circular RNA Circ_0000064 promotes the proliferation and fibrosis of mesangial cells via miR-143 in diabetic nephropathy. hsa_circ_0000064 hsa_circ_B4GALT2 - DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated Circular RNA Circ_0000064 promotes the proliferation and fibrosis of mesangial cells via miR-143 in diabetic nephropathy. 3 Hsa-circRNA-103809 Promotes Hepatocellular Carcinoma Development via MicroRNA-1270/PLAG1 Like Zinc Finger 2 Axis. - - circRNA-103809 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Hsa-circRNA-103809 promoted development of HCC via sequestering miR-1270 and up-regulating PLAGL2. 1 Circular RNA circFANCL motivates the glioma progression via the action on the miR-337-3p/HMGB1 signal axis. - hsa_circ_FANCL - DOID:0060108 brain glioma glioma RT-qPCR down-regulated "Through the illustration of oncogenic function of circFANCL in glioma by the miR-337-3p/HMGB1 axis, we believed that circFANCL might be a great target in the early diagnosis and late treatment of glioma." 1 Circular RNA hsa_circ_0005909 modulates osteosarcoma progression via the miR-936/HMGB1 axis. hsa_circ_0005909 hsa_circ_XPR1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circ_0005909 inhibition impeded the progression of OS via downregulating HMGB1 via sponging miR-936. 2 circITGA7 Functions as an Oncogene by Sponging miR-198 and Upregulating FGFR1 Expression in Thyroid Cancer. - hsa_circ_ITGA7 - DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated circITGA7 Functions as an Oncogene by Sponging miR-198 and Upregulating FGFR1 Expression in Thyroid Cancer. 1 Circular RNA_CNST Promotes the Tumorigenesis of Osteosarcoma Cells by Sponging miR-421. hsa_circ_0017311 hsa_circ_CNST - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circCNST promotes the tumorigenesis of OS cells by sponging miR-421, and provides a potential biomarker for patients with OS." 2 Circular RNA circCTNNA1 promotes colorectal cancer progression by sponging miR-149-5p and regulating FOXM1 expression. - hsa_circ_CTNNA1 - DOID:219 colon cancer colon cancer "RT-qPCR, microarray" up-regulated "circCTNNA1 facilitated CC proliferation and invasion via the circCTNNA1/miR-149-5p/FOXM1 axis, and it might function as a novel diagnostic or therapeutic target for patients with CC." 1 Hsa_circ_0046263 functions as a ceRNA to promote nasopharyngeal carcinoma progression by upregulating IGFBP3. hsa_circ_0046263 hsa_circ_P4HB - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "circ-0046263 plays a tumor-promoting role in NPC to enhance malignant behavior through the miR-133a-5p/IGFBP3 axis, which could be a potential target for NPC therapy." 1 "Circular RNA hsa_circ_0000073 contributes to osteosarcoma cell proliferation, migration, invasion and methotrexate resistance by sponging miR-145-5p and miR-151-3p and upregulating NRAS." hsa_circ_0000073 hsa_circ_OMA1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "hsa_circ_0000073 facilitated the proliferation, migration, invasion and MTX resistance of OS cells through the inhibition of miR-145-5p and miR-151-3p-mediated downregulation of NRAS." 4 Downregulation of circular RNA hsa_circ_0000735 boosts prostate cancer sensitivity to docetaxel via sponging miR-7. hsa_circ_0000735 hsa_circ_P2RX1 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Hsa_circ_0000735 downregulation boosted PCa sensitivity to DTX and reduced tumor growth via sponging miR-7, providing a promising prognostic biomarker and therapeutic target for PCa." 1 "Circular RNA ITCH suppresses proliferation, invasion, and glycolysis of ovarian cancer cells by up-regulating CDH1 via sponging miR-106a." - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "Circ-ITCH suppressed proliferation, invasion, glycolysis, and promoted apoptosis of ovarian cancer cells by modulating the miR-106a/CDH1 axis." 4 Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis. - hsa_circ_CCNB2 Circ_CCNB2 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "knockdown of circ_CCNB2 was shown to promote PCa radiosensitivity through autophagy repression by miR-30b-5p/KIF18A axis, developing a molecular resistance mechanism of PCa radiotherapy and a feasible strategy to increase radiosensitivity." 1 Circular RNA DHX33 promotes malignant behavior in ccRCC by targeting miR-489-3p/MEK1 axis. - hsa_circ_DHX33 - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, microarray" up-regulated circDHX33 plays a role in promoting ccRCC via the miR-489-3p/MEK1 axis and may serve as a novel therapeutic target for the treatment of ccRCC patients. 1 Circular RNA hsa_circ_0076690 acts as a prognostic biomarker in osteoporosis and regulates osteogenic differentiation of hBMSCs via sponging miR-152. hsa_circ_0076690 hsa_circ_RUNX2 - DOID:11476 osteoporosis osteoporosis "RT-qPCR, RNA-seq" down-regulated hsa_circ_0076690 may act as a potential diagnostic biomarker for osteoporosis patients and hsa_circ_0076690 could regulate osteogenic differentiation of hBMSCs via sponging miR-152. 1 Circular RNA circREPS2 Acts as a Sponge of miR-558 to Suppress Gastric Cancer Progression by Regulating RUNX3/beta-catenin Signaling. hsa_circ_0139996 hsa_circ_REPS2 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated circREPS2 suppresses the progression of GC via miR-558/RUNX3/beta-catenin signaling and is a novel promising biomarker and target for GC treatment. 1 "CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer In Vitro and Inhibits Tumorigenesis In Vivo via the miR-452-5p/KAT6B Axis." - hsa_circ_KIAA0907 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer In Vitro and Inhibits Tumorigenesis In Vivo via the miR-452-5p/KAT6B Axis." 3 Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway. - hsa_circ_SFMBT2 Circular RNA SFMBT2 DOID:0060108 brain glioma glioma RT-qPCR down-regulated circRNA Scm like with 4 Mbt domains 2/microRNA-182-5p/metastasis suppressor 1 axis could be a putative therapeutic target for the treatment of patients with glioma. 1 Circular RNA circ_001842 plays an oncogenic role in renal cell carcinoma by disrupting microRNA-502-5p-mediated inhibition of SLC39A14. - - circ_001842 DOID:4451 renal carcinoma renal carcinoma "RT-qPCR, microarray" up-regulated "circ_001842 in RCC pathogenesis through a miR-502-5p-dependent SLC39A14 mechanism, suggesting circ_001842 is a potential target for RCC treatment." 1 "A novel circRNA, circNUP98, a potential biomarker, acted as an oncogene via the miR-567/ PRDX3 axis in renal cell carcinoma." - hsa_circ_NUP98 - DOID:4451 renal carcinoma renal carcinoma "RT-qPCR, microarray" up-regulated "silencing of circ NUP98 inhibited RCC progression by down-regulating of PRDX3 via up-regulation of miR-567. Furthermore, STAT3 was identified as an inducer of circ NUP98 in RCC cells. CircNUP98 acts as an oncogene by a novel STAT3/circ NUP98/miR-567/PRDX3 axis, which may provide a potential biomarker and therapeutic target for the treatment of RCC." 1 Circ_0000105 promotes liver cancer by regulating miR-498/PIK3R1. hsa_circ_0000105 hsa_circ_PIK3R1 - DOID:3571 liver cancer liver cancer RT-qPCR up-regulated "Circ_0000105 overexpression promoted liver cancer cell proliferation and inhibited apoptosis, whereas knocking down circ_0000105 triggered the opposite effect. miR-498 was a downstream target of circ_0000105, inhibiting liver cancer cell proliferation and promoting apoptosis. Mechanistically, circ_0000105 indirectly up-regulated the expression of PIK3R1 by adsorbing miR-498. " 1 Circular RNA 000554 represses epithelial-mesenchymal transition in breast cancer by regulating microRNA-182/ZFP36 axis. hsa_circ_0000376 hsa_circ_PRH1-PRR4 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circRNA_000554 functioned as an inhibitor of EMT in BC and suggests a molecular mechanism that circRNA_000554 bound to miR-182 to upregulate ZFP36 in this process. 2 Circular RNA MTO1 Inhibits the Proliferation and Invasion of Ovarian Cancer Cells Through the miR-182-5p/KLF15 Axis. hsa_circ_0007874 hsa_circ_MTO1 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "Upregulation of circMTO1 inhibited proliferation and invasion of ovarian cancer cells while downregulation of circMTO1 promoted these processes. Mechanistically, we showed that circMTO1 sponged miR-182-5p to support KLF15 expression, eventually leading to inhibition of ovarian cancer progression." 2 Circular RNA circFAT1(e2) Promotes Osteosarcoma Progression and Metastasis by Sponging miR-181b and Regulating HK2 Expression. - hsa_circ_FAT1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circFAT1(e2) exerted oncogenic roles in OS and suggested the circFAT1(e2)/miR-181b/HK2 axis might be a potential therapeutic target. 2 Circular RNA hsa_circ_0001588 promotes the malignant progression of lung adenocarcinoma by modulating miR-524-3p/NACC1 signaling. hsa_circ_0001588 hsa_circ_HIST1H4E - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "hsa_circ_0001588 upregulated the expression of NACC1 by combining with miR-524-3p to promote the proliferation, migration, and invasion of lung adenocarcinoma cells, suggesting that hsa_circ_0001588 may be an underlying therapeutic target for lung adenocarcinoma." 1 Circular RNA PRKCI silencing represses esophageal cancer progression and elevates cell radiosensitivity through regulating the miR-186-5p/PARP9 axis. - hsa_circ_PRKCI - DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "CircPRKCI regulated cell malignancy and radioresistance through modulating the miR-186-5p /PARP9 axis in EC, which provided a might target for EC treatment." 1 "Circular RNA circ-CPA4/ let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)." - hsa_circ_CPA4 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "circ-CPA4 regulated cell growth, mobility, stemness and drug resistance in NSCLC cells and inactivated CD8(+) T cells in the tumor immune microenvironment through let-7 miRNA/PD-L1 axis." 2 Circular RNA MYLK Promotes Glycolysis and Proliferation of Non-Small Cell Lung Cancer Cells by Sponging miR-195-5p and Increasing Glucose Transporter Member 3 Expression. - hsa_circ_MYLK - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circular RNA MYLK Promotes Glycolysis and Proliferation of Non-Small Cell Lung Cancer Cells by Sponging miR-195-5p and Increasing Glucose Transporter Member 3 Expression. 1 Circular RNA Circ_0016760 Modulates Non-Small-Cell Lung Cancer Growth Through the miR-577/ZBTB7A Axis. hsa_circ_0016760 hsa_circ_SNAP47 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0016760 and ZBTB7A were upregulated and miR-577 was downregulated in NSCLC tissues and cells. Circ_0016760 exhaustion curbed the colony formation, migration, invasion, and ECAR of NSCLC cells in vitro and impeded tumor growth in vivo.Circ_0016760 silencing impeded NSCLC advancement through regulation of the miR-577/ZBTB7A axis." 6 circIQCH sponges miR-145 to promote breast cancer progression by upregulating DNMT3A expression. hsa_circ_0104345 hsa_circ_IQCH - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "our study demonstrated the pivotal role of circIQCH-miR-145-DNMT3A axis in breast cancer growth and metastasis via the mechanism of competing endogenous RNAs. Thus, circIQCH could be a potential therapeutic target for breast cancer." 2 Exosomes Mediated Transfer of Circ_UBE2D2 Enhances the Resistance of Breast Cancer to Tamoxifen by Binding to MiR-200a-3p. - hsa_circ_UBE2D2 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Exosomes mediated transfer of circ_UBE2D2 reinforced tamoxifen resistance in breast cancer by binding to miR-200a-3p, providing new insights into the boost of the effectiveness of tamoxifen on breast cancer patients." 2 Circ_0109291 Promotes Cisplatin Resistance of Oral Squamous Cell Carcinoma by Sponging miR-188-3p to Increase ABCB1 Expression. hsa_circ_0109291 - - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Circ_0109291 could promote the DDP resistance of OSCC, suggesting that silenced circ_0109291 might be a key step to inhibit OSCC resistance." 2 Circular RNA UBAP2 contributes to tumor growth and metastasis of cervical cancer via modulating miR-361-3p/SOX4 axis. - hsa_circ_UBAP2 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "CircUBAP2 represents a prognostic marker and contributes to tumor growth and metastasis via modulating miR-361-3p/SOX4 axis in CC, which indicates a potential therapeutic target for CC treatment." 1 The Circular RNA CDR1as Regulates the Proliferation and Apoptosis of Human Cardiomyocytes Through the miR-135a/HMOX1 and miR-135b/HMOX1 Axes. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:114 heart disease heart failure RT-qPCR up-regulated CDR1as is a potential biomarker of CHF that is mechanistically involved in the disease pathogenesis and participates in regulating the occurrence and development of CHF through the miR-135a/HMOX1 and miR-135b/HMOX1 signaling axes. 1 "Circular RNA hsa_circ_0096157 contributes to cisplatin resistance by proliferation, cell cycle progression, and suppressing apoptosis of non-small-cell lung carcinoma cells." hsa_circ_0096157 hsa_circ_MALAT1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "increased hsa_circ_0096157 expression contributed to DDP resistance in NSCLC cells by promoting cell proliferation, migration, invasion and cell cycle progression and inhibiting apoptosis." 1 Circ_0068655 Promotes Cardiomyocyte Apoptosis via miR-498/PAWR Axis. hsa_circ_0068655 hsa_circ_UBXN7 - DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated "the expression of circ_0068655 can promote cardiomyocyte apoptosis through the modulation of miR-498-PAWR axis in vitro, which highlights the diagnostic and therapeutic value of circ_0068655 in patients with MI." 2 Low expression of CircRNA HIPK3 promotes osteoarthritis chondrocyte apoptosis by serving as a sponge of miR-124 to regulate SOX8. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Our results demonstrated that CircHIPK3 was significantly upregulated in OA cartilage tissue and cells. Low expression of CircHIPK3 promoted the apoptosis of OA chondrocytes by promoting miR-124 to suppress SOX8 expression. The molecular mechanism of CircHIPK3 in present study is expected to provide new ideas for the treatment of osteoarthritis. 2 Circular RNA CirCHIPK3 promotes cell proliferation and invasion of breast cancer by sponging miR-193a/HMGB1/PI3K/AKT axis. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "CirCHIPK3 regulated miR-193a/HMGB1/PI3K/AKT signaling to facilitate BC development and progression, providing a novel therapeutic target for BC." 4 Circ0061052 regulation of FoxC1/Snail pathway via miR-515-5p is involved in the epithelial-mesenchymal transition of epithelial cells during cigarette smoke-induced airway remodeling. hsa_circ_0061052 hsa_circ_OSBPL2 - DOID:3083 chronic obstructive pulmonary disease chronic obstructive pulmonary disease RT-qPCR up-regulated "by regulating miR-515-5p through a FoxC1/Snail regulatory axis, circ0061052 is involved in the CS-induced EMT and airway remodeling in COPD." 2 Circular RNA YAP1 attenuates osteoporosis through up-regulation of YAP1 and activation of Wnt/beta-catenin pathway. hsa_circ_0024097 hsa_circ_YAP1 - DOID:11476 osteoporosis osteoporosis RT-qPCR up-regulated It was firstly uncovered in present study that circ_0024097 attenuated osteoporosis through promoting osteogenic differentiation via miR-376b-3p/YAP1 axis and Wnt/beta-catenin pathway. 1 Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/beta-catenin pathway. hsa_circ_0067934 hsa_circ_PRKCI - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0067934 acted as a competing endogenous RNA to facilitate NSCLC progression by regulating the miR-1182/KLF8 axis and activating Wnt/beta-catenin pathway. 3 Circular RNA hsa_circ_0000517 modulates hepatocellular carcinoma advancement via the miR-326/SMAD6 axis. hsa_circ_0000517 hsa_circ_RPPH1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Hsa_circ_0000517 depletion repressed HCC advancement via regulating the miR-326/SMAD6 axis. 6 "CircPOSTN/miR-361-5p/TPX2 axis regulates cell growth, apoptosis and aerobic glycolysis in glioma cells." - hsa_circ_POSTN - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circPOSTN regulated cell growth, apoptosis, and aerobic glycolysis in glioma through miR-361-5p/TPX2 axis." 5 Circular RNA circMAGI3 accelerates the glycolysis of non-small cell lung cancer through miR-515-5p/HDGF. - hsa_circ_MAGI3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circMAGI3 promoted the glycolysis and proliferation of NSCLC cells. Mechanistically, circMAGI3 functioned as a sponge for miR-515-5p to relieve its target gene HDGF expression, thereby accelerating the glycolysis of NSCLC." 2 Circular RNA circHIPK3 Promotes Cell Metastasis through miR-637/STAT3 Axis in Osteosarcoma. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated our research uncovered an important role of the circHIPK3/miR-637/STAT3 pathway in the migration and invasion of OS cells and suggested that circHIPK3 may be a prognostic marker and a promising therapeutic target for OS. 4 Downregulated circular RNA zRANB1 mediates Wnt5a/beta-Catenin signaling to promote neuropathic pain via miR-24-3p/LPAR3 axis in CCI rat models. - rno_circ_ZRANB1 - DOID:936 brain disease neuropathic pain RT-qPCR down-regulated cZRNAB1 regulated Wnt5a/beta-Catenin Signaling expression via miR-24-3p/LPAR3 axis in CCI rat models. 1 circRACGAP1 promotes non-small cell lung cancer proliferation by regulating miR-144-5p/CDKL1 signaling pathway. - hsa_circ_RACGAP1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "our study revealed a novel machinery of circRACGAP1/miR-144-5p/CDKL1 for the NSCLC tumorigenesis and development, providing potential diagnostic and therapeutic targets for NSCLC." 2 Silencing hsa_circRNA_0008035 exerted repressive function on osteosarcoma cell growth and migration by upregulating microRNA-375. hsa_circ_0008035 hsa_circ_EXT1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated silencing hsa_circRNA_0008035 exerted repressive function on OSA cell growth and migration and Notch pathway by accelerating miR-375. 1 "A Regulatory Axis of circ_0008193/miR-1180-3p/TRIM62 Suppresses Proliferation, Migration, Invasion, and Warburg Effect in Lung Adenocarcinoma Cells Under Hypoxia." hsa_circ_0008193 - circ_0008193 DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "Upregulating circ_0008193 inhibited LUAD cell proliferation, migration, invasion, and Warburg effect under hypoxia in vitro and in vivo through regulation of the miR-1180-3p/TRIM62 axis." 1 Circ_0007841 promotes the progression of multiple myeloma through targeting miR-338-3p/BRD4 signaling cascade. hsa_circ_0007841 hsa_circ_SEC61A1 - DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated "Circ_0007841 acted as an oncogene to promote the proliferation, cell cycle and motility and restrain the apoptosis of MM cells through sequestering miR-338-3p to up-regulate the expression of BRD4." 5 Effects of the circ_101238/miR-138-5p/CDK6 axis on proliferation and apoptosis keloid fibroblasts. - - circ_101238 DOID:10881 "hand, foot and mouth disease" keloid RT-qPCR up-regulated circ_101238 may serve as a promising therapeutic candidate for keloid therapy and that circ_101238/miR-138-5p/CDK6 signaling has the potential to regulate the growth of keloid fibroblasts. 1 "Protective effects of P2X7R antagonist in sepsis-induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression." mmu_circ_0001679 - circ_0001679 DOID:0040085 bacterial sepsis sepsis-induced acute lung injury (ALI) "RT-qPCR, RNA-seq" up-regulated "P2X(7) R antagonism attenuates sepsis-induced ALI by inhibiting dysregulated expression of circRNA (circ_0001679, circ_0001212) and mRNA (Pln, Cdh2 and Nprl3)" 1 "Protective effects of P2X7R antagonist in sepsis-induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression." mmu_circ_0001212 - circ_0001212 DOID:0040085 bacterial sepsis sepsis-induced acute lung injury (ALI) "RT-qPCR, RNA-seq" up-regulated "P2X(7) R antagonism attenuates sepsis-induced ALI by inhibiting dysregulated expression of circRNA (circ_0001679, circ_0001212) and mRNA (Pln, Cdh2 and Nprl3)" 1 Serum-Derived Exosomes-Mediated Circular RNA ARHGAP10 Modulates the Progression of Non-Small Cell Lung Cancer Through the miR-638/FAM83F Axis. - hsa_circ_ARHGAP10 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Inhibition of serum-derived exosomes-mediated circARHGAP10 curbed NSCLC progression through the miR-638/FAM83F axis. 2 Circular RNA hsa_Circ_101141 as a Competing Endogenous RNA Facilitates Tumorigenesis of Hepatocellular Carcinoma by Regulating miR-1297/ROCK1 Pathway. - - hsa_circ_101141 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circRNA circ_101141 acted as a ceRNA to facilitate tumorigenesis of HCC by regulating miR-1297/ROCK1 pathway. 1 "Interference with circBC048201 inhibits the proliferation, migration, and invasion of bladder cancer cells through the miR-1184/ITGA3 axis." - hsa_circ_BC048201 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circBC048201 was abnormally highly expressed in bladder cancer tissues and cells, and the interference with circBC048201 inhibited the proliferation, migration, and invasion of bladder cancer cells through the miR-1184/ITGA3 axis." 2 "CircRSF1 contributes to endothelial cell growth, migration and tube formation under ox-LDL stress through regulating miR-758/CCND2 axis." - hsa_circ_RSF1 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated "CircRSF1 could protect against ox-LDL-induced endothelial cell injury in vitro via miR-758/CCND2 axis, suggesting circRSF1 as a potential target for the treatment of atherosclerosis." 3 Circular RNA circTNPO3 Regulates Paclitaxel Resistance of Ovarian Cancer Cells by miR-1299/NEK2 Signaling Pathway. - hsa_circ_TNPO3 - DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, microarray" up-regulated circTNPO3 contributed to PTX resistance of OC cells at least partly through upregulating NEK2 expression by sponging miR-1299. circTNPO3/miR-1299/NEK2 signaling pathway might play vital roles in the tumorigenesis and chemoresistance of OC. 2 The circular RNA circ-GRB10 participates in the molecular circuitry inhibiting human intervertebral disc degeneration. - hsa_circ_GRB10 - DOID:90 degenerative disc disease intervertebral disc degeneration RT-qPCR down-regulated "circ-GBR10 participates in the molecular circuitry that controls human IDD development. These findings provide a basis for further functional, diagnostic and therapeutic studies of circ-GRB10 in IDD." 3 Circular RNA DGKB Promotes the Progression of Neuroblastoma by Targeting miR-873/GLI1 Axis. hsa_circ_0133622 hsa_circ_DGKB - DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated our work proved that circDGKB promoted NB progression via targeting miR-873/GLI1 axis in vitro and in vivo. Our study provided a new target for NB treatment and indicated that circDGKB could act as a novel diagnostic marker for NB. 1 Circular RNA circ-SLC7A6 acts as a tumor suppressor in non-small cell lung cancer through abundantly sponging miR-21. - hsa_circ_SLC7A6 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "circ-SLC7A6 is a novel tumor suppressor in NSCLC, targeting circ-SLC7A6/miR-21 axis may be a promising treatment for NSCLC patients." 1 "Hsa_circ_0029589 knockdown inhibits the proliferation, migration and invasion of vascular smooth muscle cells via regulating miR-214-3p and STIM1." hsa_circ_0029589 hsa_circ_CHFR - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Circ_0029589 knockdown repressed proliferation, migration and invasion of VSMCs challenged via ox-LDL by regulating miR-214-3p and STIM1, indicating that circ_0029589 might play important role in atherosclerosis." 6 Circular noncoding RNA circMBOAT2 is a novel tumor marker and regulates proliferation/migration by sponging miR-519d-3p in colorectal cancer. - hsa_circ_MBOAT2 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circMBOAT2 regulated cell proliferation and migration by competitively binding to miR-519d-3p and targeting troponin-associated protein (TROAP) in CRC cells. 1 An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. - mmu_circ_Kcnt2 circKcnt2 DOID:0060180 colitis colitis "RT-qPCR, microarray" down-regulated our data support a function of the circRNA circKcnt2 in regulating ILC3 inactivation and resolution of innate colitis 1 Circ_WBSCR17 aggravates inflammatory responses and fibrosis by targeting miR-185-5p/SOX6 regulatory axis in high glucose-induced human kidney tubular cells. - mmu_circ_WBSCR17 - DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "Circ_WBSCR17 triggered the dysfunction of HG-induced HK-2 cells, including inflammatory responses and fibrosis, which was accomplished via the miR-185-5p/SOX6 regulatory axis." 1 CircTADA2A suppresses the progression of colorectal cancer via miR-374a-3p/KLF14 axis. - hsa_circ_TADA2A - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated CircTADA2A functioned as a tumor suppressor in CRC to inhibit the glycolysis and cell cycle and potentiate the apoptosis of CRC cells via miR-374a-3p/KLF14 axis. 3 CircZNF609 is involved in the pathogenesis of focal segmental glomerulosclerosis by sponging miR-615-5p. - mmu_circ_ZNF609 - DOID:1312 focal segmental glomerulosclerosis focal segmental glomerulosclerosis RT-qPCR up-regulated circZNF609 may play an important role in FSGS by sponging miR-615-5p. 1 CircPlekha7 plays an anti-fibrotic role in intrauterine adhesions by modulating endometrial stromal cell proliferation and apoptosis. - hsa_circ_Plekha7 - DOID:13812 adhesions of uterus intrauterine adhesions "RT-qPCR, RNA-seq" up-regulated "circPlekha7 plays an anti-fibrotic role in IUA and may serve as a promising prognostic biomarker for patients with IUA. Therefore, overexpression of circPlekha7 could be a potential treatment strategy for IUA." 1 Circular RNA circLPAR3 Facilitates Esophageal Squamous Cell Carcinoma Progression Through Upregulating HMGB1 via Sponging miR-375/miR-433. - hsa_circ_LPAR3 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "CircLPAR3 might play an oncogenic role in ESCC through sponging miR-375/miR-433 to promote HMGB1 expression, which might provide a theoretical basis for circLPAR3 to become a biomarker for ESCC therapy." 2 Circular RNA ZNF609 Promoted Hepatocellular Carcinoma Progression by Upregulating PAP2C Expression via Sponging miR-342-3p. - hsa_circ_ZNF609 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated CircZNF609 was highly expressed in HCC tissues and driven HCC progression by sponging miR-342-3p and upregulating RAP2C. This study may provide new potential therapeutic targets for HCC treatment. 2 CircEPSTI1 Promotes the Progression of Non-Small Cell Lung Cancer Through miR-145/HMGB3 Axis. - hsa_circ_EPSTI1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircEPSTI1 aggravated the progression of NSCLC through elevating the expression of HMGB3 via sponging miR-145. 2 Circ_0046599 Promotes the Development of Hepatocellular Carcinoma by Regulating the miR-1258/RPN2 Network. hsa_circ_0046599 - Circ_0046599 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Our results provided new evidence that circ_0046599 could promote the progression of HCC by increasing RPN2 expression via sponging miR-1258. 1 A novel circular RNA hsa_circ_0060927 may serve as a potential diagnostic biomarker for human colorectal cancer. hsa_circ_0060927 hsa_circ_CYP24A1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "the results of our study illustrated the expression levels hsa_circ_0060927 in CRC; however, further studies are required to validate the present results." 2 Up-regulation of circular RNA hsa_circ_01844 induces apoptosis and suppresses proliferation and migration of glioblastoma cells. - - hsa_circ_01844 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated "Hsa_circ_01844 shows decreased expression in glioblastoma and its overexpression induces apoptosis and inhibits proliferation, migration, and invasion of glioblastoma cells." 1 Circ-SMARCA5 suppresses colorectal cancer progression via downregulating miR-39-3p and upregulating ARID4B. - hsa_circ_SMARCA5 Circ-SMARCA5 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Circ-SMARCA5 functions as a tumor suppressor by upregulating ARID4B expression via sponging miR-39-3p, and thereby inhibited CRC progression." 1 CircPSMC3 alleviates the symptoms of PCOS by sponging miR-296-3p and regulating PTEN expression. - hsa_circ_PSMC3 CircPSMC3 DOID:229 female reproductive system disease Polycystic ovary syndrome RT-qPCR down-regulated we preliminarily characterized the role and possible insights of circPSMC3/miR-296-3p/PTEN axis in the proliferation and apoptosis of KGN cells 1 Circulating exosomal circFoxp1 confers cisplatin resistance in epithelial ovarian cancer cells. - hsa_circ_Foxp1 - DOID:2152 ovary epithelial cancer epithelial ovarian cancer RT-qPCR up-regulated circFoxp1 is an oncogene in EOC cells and can confer DDP resistance to EOC cells. Circulating exosomal circFoxp1 can be used as a biomarker and potential therapeutic target for EOC. 1 CircIL4R facilitates the tumorigenesis and inhibits ferroptosis in hepatocellular carcinoma by regulating the miR-541-3p/GPX4 axis. - hsa_circ_IL4R - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated CircIL4R played an oncogenic role in HCC via the miR-541-3p/GPX4 axis in vivo. Our data suggested that circIL4R served for a tumor promoter and ferroptosis inhibitor in HCC by the miR-541-3p/GPX4 network. 1 Circular RNA PRMT5 confers cisplatin-resistance via miR-4458/REV3L axis in non-small-cell lung cancer. - hsa_circ_PRMT5 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "Circ-PRMT5 promoted DDP resistance via REV3L by sponging miR-4458 in NSCLC, thus providing a novel therapeutic strategy for patients with NSCLC." 3 Hypoxia inducible factor-1 (HIF-1alpha) reduced inflammation in spinal cord injury via miR-380-3p/ NLRP3 by Circ 0001723. hsa_circ_0001723 - Circ 0001723 DOID:319 spinal cord disease spinal cord injury RT-qPCR down-regulated We concluded that HIF-1alpha reduced inflammation in spinal cord injury via miR-380-3p/ NLRP3 by Circ 0001723. 1 CircHIPK3 Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Cells Proliferation and Metastasis via Altering of miR-508-3p/CXCL13 Signal. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated circHIPK3 promoted ccRCC cell proliferation and metastasis by altering miR-5083p/CXCL13 signaling. The present findings might provide a novel target for the molecular treatment of ccRCC. 1 Knockdown of circ_0000512 Inhibits Cell Proliferation and Promotes Apoptosis in Colorectal Cancer by Regulating miR-296-5p/RUNX1 Axis. hsa_circ_0000512 hsa_circ_RPPH1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Knockdown of circ_0000512 inhibited cell proliferation and induced apoptosis in CRC cell by regulating miR-296-5p/RUNX1 axis, which might provide a potential therapeutic target for CRC treatment." 1 circ_0136666 Facilitates the Progression of Colorectal Cancer via miR-383/CREB1 Axis. hsa_circ_0136666 - - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circ_0136666 deteriorated CRC through miR-383/CREB1 axis. circ_0136666/miR-383/CREB1 axis might be an underlying therapeutic target for CRC therapy. 3 Analysis of Circular RNAs in the Coronary Arteries of Patients with Kawasaki Disease. - hsa_circ_WHAMMP1 - DOID:13378 Kawasaki disease kawasaki disease RNA-seq down-regulated "For circWHAMMP1 and circZNF124, the microRNAs that may be regulated by these circRNAs were also identified." 1 Analysis of Circular RNAs in the Coronary Arteries of Patients with Kawasaki Disease. - hsa_circ_ZNF124 - DOID:13378 Kawasaki disease kawasaki disease RNA-seq down-regulated "For circWHAMMP1 and circZNF124, the microRNAs that may be regulated by these circRNAs were also identified." 1 Hsa_circ_0008934 promotes the proliferation and migration of osteosarcoma cells by targeting miR-145-5p to enhance E2F3 expression. hsa_circ_0008934 hsa_circ_ASAP1 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated Elevated hsa_circ_0008934 expression promotes the proliferation and migration of osteosarcoma cells by sponging miR-145-5p to enhance E2F3 expression. 1 Circ_0000218 plays a carcinogenic role in laryngeal cancer through regulating microRNA-139-3p/Smad3 axis. hsa_circ_0000218 hsa_circ_DCLRE1C - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated Circ_0000218 inhibition inhibited the growth of LSCC by targeting miR-139-3p/Smad3 axis. 1 Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress. - mmu_circ_VMA21 - DOID:3021 acute kidney failure acute kidney injury RT-qPCR down-regulated Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress. 1 Circ_0010220-mediated miR-503-5p/CDCA4 axis contributes to osteosarcoma progression tumorigenesis. hsa_circ_0010220 hsa_circ_ARHGEF10L - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated circ_0010220 can be an important biomarker for osteosarcoma via regulating miR-503-5p and CDCA4. 3 CircZNF609 aggravates neuropathic pain via miR-22-3p/ENO1 axis in CCI rat models. - mmu_circ_ZNF609 - DOID:936 brain disease neuropathic pain RT-qPCR up-regulated circZNF609 promoted inflammation factors expression to aggravate neuropathic pain progression via miR-22-3p/ENO1 axis in CCI rat models. 1 Downregulation of circEPSTI1 represses the proliferation and invasion of non-small cell lung cancer by inhibiting TRIM24 via miR-1248 upregulation. - hsa_circ_EPSTI1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated downregulation of circEPSTI1 represses the proliferation and invasion of NSCLC by inhibiting TRIM24 via miR-1248 upregulation. 2 Circular RNA has circ 0001591 promoted cell proliferation and metastasis of human melanoma via ROCK1/PI3K/AKT by targeting miR-431-5p. hsa_circ_001436 - - DOID:1909 melanoma melanoma RT-qPCR up-regulated circ 0001591 inhibits the progression of human melanoma through ROCK1/PI3K/AKT signal pathway by targeting ROCK1 by miR-431-5p. 1 Circular RNA SIPA1L1 promotes osteogenesis via regulating the miR-617/Smad3 axis in dental pulp stem cells. - hsa_circ_SIPA1L1 - DOID:12347 osteogenesis imperfecta osteogenesis "RT-qPCR, RNA-seq" up-regulated CircRNASIPA1L1 promotes osteogenesis of DPSCs by adsorbing miR-617 and further targeting Smad3. 2 Circular RNA circ_0020123 promotes non-small cell lung cancer progression by sponging miR-590-5p to regulate THBS2. hsa_circ_0020123 hsa_circ_PDZD8 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circular RNA circ_0020123 regulated THBS2 by sponging miR-590-5p to promote cell proliferation and migration and inhibit cell apoptosis in NSCLC cells. 9 FOXA1-induced circOSBPL10 potentiates cervical cancer cell proliferation and migration through miR-1179/UBE2Q1 axis. - hsa_circ_OSBPL10 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "FOXA1-induced circOSBPL10 facilitates CC progression through miR-1179/UBE2Q1 axis, highlighting a strong potential for circOSBPL10 to serve as a promising therapeutic target in CC." 1 CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression. - hsa_circ_ZFR - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "the silencing of circZFR suppressed BC malignant progression in vitro via the regulation of the miR-578/HIF1A axis, providing evidence for the crucial involvement of circZFR in BC pathogenesis." 2 Knockdown of circHIPK3 Facilitates Temozolomide Sensitivity in Glioma by Regulating Cellular Behaviors Through miR-524-5p/KIF2A-Mediated PI3K/AKT Pathway. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:0060108 brain glioma glioma RT-qPCR down-regulated "Knockdown of circHIPK3 promoted TMZ sensitivity in glioma by modulating proliferation, metastasis, and apoptosis through miR-524-5p/KIF2A-mediated PI3K/AKT pathway. CircHIPK3 may be the potential target for the diagnosis and therapy of TMZ-resistant glioma." 7 Circ_0011292 Enhances Paclitaxel Resistance in Non-Small Cell Lung Cancer by Regulating miR-379-5p/TRIM65 Axis. hsa_circ_0011292 hsa_circ_TINAGL1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0011292 facilitated tumorigenesis and PTX resistance in NSCLC by regulating the miR-379-5p/TRIM65 axis, suggesting that circ_0011292 was a promising therapeutic target for NSCLC chemotherapy." 2 "Circ_0079593 facilitates proliferation, metastasis, glucose metabolism and inhibits apoptosis in melanoma by regulating the miR-516b/GRM3 axis." hsa_circ_0079593 hsa_circ_IGF2BP3 - DOID:1909 melanoma melanoma RT-qPCR up-regulated "circ_0079593 accelerated melanoma progression via upregulating GRM3 by sponging miR-516b, which suggested that circ_0079593 had the potential to be a new therapeutic biomarker for melanoma." 2 [Effect of circular RNA hsa_circ_0008898 on oral squamous cell carcinoma and its mechanism]. hsa_circ_0008898 hsa_circ_OAT - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Knockdown of hsa_circ_0008898 inhibited OSCC cells proliferation, cloning, migration and invasion and induced cell cycle arrest in vitro by regulating the miR-197-5p/RHOA. Additionally, Knockdown of hsa_circ_0008898 also inhibited tumor formation of OSCC cells in vivo." 1 Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis. hsa_circ_0000034 hsa_circ_DHDDS - DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated "ADAM19 overexpression abolished the influence of miR-361-3p mimic on viability, migration, invasion, apoptosis, and EMT of RB cells. Circ_0000034 expedited RB progression through upregulating ADAM19 via sponging miR-361-3p, which indicated that circ_0000034 might a target for RB therapy." 3 CircC3P1 attenuated pro-inflammatory cytokine production and cell apoptosis in acute lung injury induced by sepsis through modulating miR-21. - mmu_circ_C3P1 CircC3P1 DOID:0040085 bacterial sepsis sepsis RT-qPCR dysregulated "CircC3P1 attenuated pro-inflammatory cytokine production and cell apoptosis in ALI induced by sepsis through modulating miR-21, indicating that circC3P1 is a promising therapeutic biomarker for sepsis-induced ALI" 1 CircRNA hsa_circ_0002577 accelerates endometrial cancer progression through activating IGF1R/PI3K/Akt pathway. hsa_circ_0002577 hsa_circ_WDR26 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "circRNA hsa_circ_002577 accelerated EC progression by acting as a miR-625-5p sponge, upregulating IGF1R and activating the PI3K/Akt pathway, suggesting the potential therapeutic use of hsa_circ_002577 in EC treatment." 4 Rno_circ_0005139 regulates apoptosis by targeting Wnt5a in rat anorectal malformations. rno_circ_0005139 - Rno_circ_0005139 DOID:1285 rectal disease anorectal malformation "RT-qPCR, RNA-seq, microarray" down-regulated "Rno_circ_0005139 influences cell proliferation and apoptosis by acting as a miR-324-3p sponge, thereby downregulating Wnt5a in ARM. Accordingly, rno_circ_0005139, miR-324-3p, and Wnt5a could be targeted therapeutic factors for ARM." 1 The Potential Tumor Promotional Role of circVAPA in Retinoblastoma via Regulating miR-615-3p and SMARCE1. - hsa_circ_VAPA - DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated "circVAPA promoted RB proliferation and metastasis by sponging miR-615-3p, thereby upregulating SMARCE1. CircVAPA was a potential biomarker for Rb therapy." 1 "Circular RNA MAT2B Induces Colorectal Cancer Proliferation via Sponging miR-610, Resulting in an Increased E2F1 Expression." - hsa_circ_MAT2B - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circMAT2B promoted CRC proliferation by regulating the miR-610/E2F1 axis, which may serve as a potential therapeutic target for CRC treatment." 1 Circular RNA circNHSL1 Contributes to Gastric Cancer Progression Through the miR-149-5p/YWHAZ Axis. - hsa_circ_NHSL1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circNHSL1 knockdown repressed migration, invasion, and glutaminolysis in vitro and inhibited tumor growth in vivo by miR-149-5p/YWHAZ axis in GC, implying an underlying circRNA-targeted therapy for GC treatment." 2 Circular RNA 103862 Promotes Proliferation and Invasion of Laryngeal Squamous Cell Carcinoma Cells Through the miR-493-5p/GOLM1 Axis. - - circRNA_103862 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "circRNA_103862 promotes the proliferation of LSCC through targeting the miR-493-5p/GOLM1 axis, and it might serve as a potential prognosis marker and therapy target for LSCC." 1 Circular RNA cMTO1 Promotes PTEN Expression Through Sponging miR-181b-5p in Liver Fibrosis. hsa_circ_0007874 hsa_circ_MTO1 cMTO1 DOID:409 liver disease liver fibrosis RT-qPCR down-regulated "cMTO1 inhibits HSC activation, at least in part, through miR-181b-5p-mediated PTEN expression. Our results also suggest that cMTO1 may be a novel therapeutic target in liver fibrosis." 1 Circular RNA circCCDC66 Contributes to Malignant Phenotype of Osteosarcoma by Sponging miR-338-3p to Upregulate the Expression of PTP1B. - hsa_circ_CCDC66 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "circCCDC66 contributed to malignant behaviors of OS cells by miR-338-3p/PTP1B pathway, which suggested circCCDC66/miR-338-3p/PTP1B axis might be a potential therapeutic target." 1 Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway. hsa_circ_0026359 hsa_circ_KRT7 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated miR-1200/POLD4 pathway mediated the promoting role of circ_0026359 in CDDP resistance of gastric cancer. circ_0026359 could be used as a potential target for CDDP-resistant gastric cancer therapy. 1 circ_0037128/miR-17-3p/AKT3 axis promotes the development of diabetic nephropathy. hsa_circ_0037128 hsa_circ_NPRL3 - DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated we have characterized the function of a novel circ_0037128 and illustrated the significance of circ_0037128-miR-17-3p-AKT3 axis in DN pathogenesis. 2 Circ_0005075 targeting miR-151a-3p promotes neuropathic pain in CCI rats via inducing NOTCH2 expression. hsa_circ_0005075 - circ_0005075 DOID:0060164 pain disorder neuropathic pain RT-qPCR up-regulated we indicated that loss ofcirc_0005075relieved neuropathic pain progression by inducement of miR-151a-3p and inactivation of NOTCH2 signaling. 1 "Circular RNA circ_0029589 regulates proliferation, migration, invasion, and apoptosis in ox-LDL-stimulated VSMCs by regulating miR-424-5p/IGF2 axis." hsa_circ_0029589 hsa_circ_CHFR - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Circ_0029589 silence might inhibit the progression of AS by regulating miR-424-5p/IGF2 axis, providing a novel mechanism for pathogenesis of AS." 6 Circular RNA circ_0000517 regulates hepatocellular carcinoma development via miR-326/IGF1R axis. hsa_circ_0000517 hsa_circ_RPPH1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ_0000517 knockdown repressed hepatocellular carcinoma development in vitro and in vivo by modulating miR-326 and IGF1R. 6 "Circ_0000140 restrains the proliferation, metastasis and glycolysis metabolism of oral squamous cell carcinoma through upregulating CDC73 via sponging miR-182-5p." hsa_circ_0000140 - Circ_0000140 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "Circ_0000140 restrains the proliferation, metastasis and glycolysis metabolism of oral squamous cell carcinoma through upregulating CDC73 via sponging miR-182-5p." 2 Circ_0007031 enhances tumor progression and promotes 5-fluorouracil resistance in colorectal cancer through regulating miR-133b/ABCC5 axis. hsa_circ_0007031 hsa_circ_TUBGCP3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Our current work had led to the identification of circ_0007031 knockdown that repressed CRC cell malignant progression and enhanced 5-FU sensitivity via regulating ABCC5 expression by sponging miR-133b. 4 "CircDHDDS/miR-361-3p/WNT3A Axis Promotes the Development of Retinoblastoma by Regulating Proliferation, Cell Cycle, Migration, and Invasion of Retinoblastoma Cells." - hsa_circ_DHDDS - DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated "circDHDDS/miR-361-3p/WNT3A axis stimulated the development of RB by regulation of proliferation, cell cycle program, migration, and invasion of RB cells." 3 The circRNA circ_0000291 acts as a sponge of microRNA 326 to regulate E26 transformation-specific sequence-1 expression and promote breast cancer progression. hsa_circ_0000291 hsa_circ_CD44 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0000291 is the novel oncogenic circRNA and promotes BC progression via modulating the miR-326/ETS1 axis. 2 hsa_circ_0003738 Inhibits the Suppressive Function of Tregs by Targeting miR-562/IL-17A and miR-490-5p/IFN-gamma Signaling Pathway. hsa_circ_0003738 hsa_circ_LRRC16A - DOID:8893 psoriasis psoriasis RT-qPCR up-regulated "upregulated circ_0003738 decreased the suppressive function of psoriatic Tregs via the miR-562/IL17RA and miR-490-5p/IFNGR2 (IFN-gamma receptor 2) axis, which indicated the involvement of circRNAs in the pathogenesis of dysfunctional Tregs. These findings will provide new therapeutic targets for the treatment of psoriasis." 1 CircRNA circ_0072995 promotes the progression of epithelial ovarian cancer by modulating miR-147a/CDK6 axis. hsa_circ_0072995 hsa_circ_RGNEF - DOID:2152 ovary epithelial cancer epithelial ovarian cancer RT-qPCR up-regulated CircRNA circ_0072995 promotes the progression of epithelial ovarian cancer by modulating miR-147a/CDK6 axis. 1 "hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223." hsa_circ_001587 hsa_circ_TCONS_00003590 - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223." 1 Circular RNA circEXOC6B Inhibits the Progression of Ovarian Cancer by Sponging miR-421 and Regulating RUS1 Expression. - hsa_circ_EXOC6B - DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "we found that circEXOC6B suppressed the growth of ovarian cancer cells through upregulating RSU1 partially via sponging miR-421. Therefore, circEXOC6B might be a potential target for the treatment of ovarian cancer." 2 "Blocking circ_0013912 Suppressed Cell Growth, Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells in vitro and in vivo Partially Through Sponging miR-7-5p." hsa_circ_0013912 hsa_circ_POLR3C - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated Circ_0013912 knockdown could suppress cell growth and metastasis of PDAC cells via sponging miR-7-5p. 1 Circ_0015756 Aggravates Hepatocellular Carcinoma Development by Regulating FGFR1 via Sponging miR-610. hsa_circ_0015756 hsa_circ_CFH - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Circ_0015756 played its tumorigenic properties in HCC by activating FGFR1 via sponging miR-610, and circ_0015756 was expected to be a vital indicator in HCC diagnosis and treatment." 3 Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer. hsa_circ_0044556 hsa_circ_COL1A1 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated Hsa_circ_0044556 promoted the progression of CRC. It is possible that hsa_circ_0044556 will become a novel biomarker or therapeutic target for CRC. 2 Circular RNA HIPK3 exacerbates diabetic nephropathy and promotes proliferation by sponging miR-185. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated circHIPK3 exhibits a promotive function in DN by sponging miR-185 and this evidence suggests that circHIPK3 might be a biomarker or therapeutic target for DN. 3 "Circular RNA circ_0007142 regulates cell proliferation, apoptosis, migration and invasion via miR-455-5p/SGK1 axis in colorectal cancer." hsa_circ_0007142 hsa_circ_DOCK1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0007142/miR-455-5p/SGK1 axis regulated cell proliferation, apoptosis, migration and invasion of CRC cells, providing a probable therapy target for CRC." 4 Circ_0000144 facilitates the progression of thyroid cancer via the miR-217/AKT3 pathway. hsa_circ_0000144 hsa_circ_SLAMF6 - DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated Circ_0000144 exerts a cancer-promoting effect on TC cells via the miR-217/AKT3 pathway. 1 Circular RNA Circ_0000442 acts as a sponge of MiR-148b-3p to suppress breast cancer via PTEN/PI3K/Akt signaling pathway. hsa_circ_0000442 hsa_circ_MED13L - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated Circular RNA Circ_0000442 acts as a sponge of MiR-148b-3p to suppress breast cancer via PTEN/PI3K/Akt signaling pathway. 2 Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p. hsa_circ_0000034 hsa_circ_DHDDS - DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated "hsa_circ_0000034 promoted the oncogenicity of retinoblastoma via regulation of miR-361-3p expression, a finding that may contribute toward retinoblastoma therapeutics." 3 Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "Rather than acting as a miRNA sponge, CDR1as functions as a tumor suppressor through binding directly to p53 at its DBD region to restrict MDM2 interaction. Thus, CDR1as binding disrupts the p53/MDM2 complex to prevent p53 from ubiquitination and degradation. CDR1as may also sense DNA damage signals and form a protective complex with p53 to preserve p53 function." 2 Circular RNA circ-MTO1 serves as a novel potential diagnostic and prognostic biomarker for gallbladder cancer. - hsa_circ_MTO1 circ-MTO1 DOID:3121 gallbladder cancer gallbladder cancer RT-qPCR up-regulated "Circ-MTO1 is a potential early diagnostic and prognostic biomarker for patients with gallbladder cancer. Thus, our present work might provide a new understanding of the diagnosis and treatment of GBC." 1 "Knockdown of circ0082374 inhibits cell viability, migration, invasion and glycolysis in glioma cells by miR-326/SIRT1." hsa_circ_0082374 hsa_circ_CPA4 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "silence of circ0082374 repressed the viability, migration, invasion and glycolysis in glioma cells by regulating miR-326 and SIRT1 in a ceRNA mechanism, providing a new mechanism for the pathogenesis of glioma." 3 Knockdown of circular RNA circMAT2B reduces oxygen-glucose deprivation-induced inflammatory injury in H9c2 cells through up-regulating miR-133. - hsa_circ_MAT2B - DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated circMAT2B knockdown works as an inflammatory inhibitor in OGD-induced H9c2 cells inflammatory injury through up-regulating miR-133. 1 "A novel identified circular RNA, circ_0000491, aggravates the extracellular matrix of diabetic nephropathy glomerular mesangial cells through suppressing miR_101b by targeting TGFbetaRI." mmu_circ_0000491 - - DOID:557 kidney disease diabetic nephropathy "RT-qPCR, RNA-seq" up-regulated "circRNA_0000491/miR_101b/TGFbetaRI axis in ECM accumulation and fibrosis_associated protein expression levels of mesangial cells, which suggested that circRNA_0000491 may be beneficial for the development of an effective therapeutic target for DN." 1 Circular RNA NOX4 promotes the development of colorectal cancer via the microRNA_485_5p/CKS1B axis. hsa_circ_0023990 hsa_circ_NOX4 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circNOX4 may serve an oncogenic role in CRC by promoting the proliferation, migration, invasion and glycolysis of CRC cells via the miR_485_5p/CKS1B axis." 2 Circular RNA circNFATC3 acts as a miR-9-5p sponge to promote cervical cancer development by upregulating SDC2. hsa_circ_0005615 hsa_circ_NFATC3 - DOID:4362 cervical cancer cervical cancer "RT-qPCR, microarray" up-regulated "Our data indicate that circNFATC3 sponges miR-9-5p to regulate SDC2 expression and, thereby, to promote CC tumor development." 2 "CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-beta2 axis under hypoxia." mmu_circ_0001052 mmu_circ_HIPK3 - DOID:114 heart disease cardiac fibrosis RT-qPCR up-regulated "These findings demonstrated that circHIPK3 acted as a miR-152-3p sponge to regulate CF proliferation, migration and phenotypic transformation through TGF-beta2, revealing that modulation of circHIPK3 expression may represent a potential target to promote the transition of hypoxia-induced CFs to myofibroblasts." 1 The Significance of Circular RNA DDX17 in Prostate Cancer. - hsa_circ_DDX17 - DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated our findings indicated that the circDDX17/miR-346/LHPP pathway inhibited the progression of prostate cancer and that circDDX17 may be a new potential therapeutic or diagnostic target for treating and diagnosing prostate cancer. 2 Circular RNA MYLK Promotes Hepatocellular Carcinoma Progression Through the miR29a/KMT5C Signaling Pathway. - hsa_circ_MYLK - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circMYLK promotes HCC progression by acting as a competing endogenous RNA of miR-29a, which regulates the downstream oncogene KMT5C." 2 Exosomal circFBLIM1 Promotes Hepatocellular Carcinoma Progression and Glycolysis by Regulating the miR-338/LRP6 Axis. hsa_circ_0010090 hsa_circ_FBLIM1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircFBLIM1 facilitated HCC progression and glycolysis via modulating the miR-338/LRP6 axis, which may provide promising therapeutic targets for HCC." 1 Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p. - hsa_circ_ZNF292 - DOID:0070353 cataract age-related cataract "RT-qPCR, RNA-seq" down-regulated "circZNF292, a down-regulated circRNA in the anterior lens capsule of ARC patients, may be involved in resistance to oxidative damage and apoptosis of lens epithelial cells by sponging miR-23b-3p, providing a potential target for prevention and treatment of ARC." 1 Novel circular RNA 2960 contributes to secondary damage of spinal cord injury by sponging miRNA-124. - - circRNA2960 DOID:319 spinal cord disease spinal cord injury RT-qPCR up-regulated "A novel circRNA-2960 was the most significantly upregulated in the SCI group. It could downregulate its target molecule miRNA_124, then exacerbate the inflammatory response and induce apoptosis at the lesion site." 1 CircMMP1 promotes the progression of glioma through miR-433/HMGB3 axis in vitro and in vivo. hsa_circ_0024108 hsa_circ_MMP1 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated CircMMP1 promoted the progression of glioma through acting as a competitive endogenous RNA (ceRNA) of miR-433 to up-regulate HMGB3. CircMMP1 level in serum exosomes might be a potential marker for the diagnosis of glioma patients. Targeting circMMP1/miR-433/HMGB3 signaling might be a novel insight for glioma treatment. 2 circCRKL suppresses the progression of prostate cancer cells by regulating the miR-141/KLF5 axis. - hsa_circ_CRKL - DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated "These findings revealed that circCRKL inhibited the progression of PCa through upregulating KLF5 expression by sponging miR-141, elucidating a novel regulatory pathway in PCa cells. Our research suggested an underlying circRNA-targeted therapy for PCa." 2 "Downregulation of Hsa_circ_0000735 Inhibits the Proliferation, Migration, Invasion, and Glycolysis in Non-small-cell Lung Cancer by Targeting miR-940/BMPER Axis." hsa_circ_0000735 hsa_circ_P2RX1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0000735 regulated proliferation, migration, invasion, and glycolysis in NSCLC cells by targeting miR-940/BMPER axis." 4 Circular RNA circRNA_103809 Accelerates Bladder Cancer Progression and Enhances Chemo-Resistance by Activation of miR-516a-5p/FBXL18 Axis. hsa_circ_0103809 - - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circRNA_103809 promotes proliferation, migration, invasion and chemo-resistance of BC cells through regulating miR-516a-5p/FBXL18 axis." 1 "Circ_0000376, a Novel circRNA, Promotes the Progression of Non-Small Cell Lung Cancer Through Regulating the miR-1182/NOVA2 Network." hsa_circ_0000376 hsa_circ_PRH1-PRR4 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0000376 promoted NSCLC progression by regulating the miR-1182/NOVA2 axis, suggesting that circ_0000376 might be a potential biomarker for NSCLC treatment." 4 "Blocking circ_0000520 Suppressed Breast Cancer Cell Growth, Migration and Invasion Partially via miR-1296/SP1 Axis Both in vitro and in vivo." hsa_circ_0000520 hsa_circ_RPPH1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_0000520 knockdown could suppress cell growth, migration and invasion both in vitro and in vivo through regulating miR-1296/SP1 pathway." 9 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. - - circRNA_0031 DOID:0060224 atrial fibrillation atrial fibrillation "RT-qPCR, microarray" up-regulated "All of 4 upregulated circRNAs (circRNA_0031, circRNA_1837, circRNA_5901 and circRNA_7571) and 3 out of 4 downregulated circRNAs (circRNA_5801, circRNA_7386 and circRNA_7577) were randomly confirmed by RT-PCR." 1 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. - - circRNA_1837 DOID:0060224 atrial fibrillation atrial fibrillation "RT-qPCR, microarray" up-regulated "All of 4 upregulated circRNAs (circRNA_0031, circRNA_1837, circRNA_5901 and circRNA_7571) and 3 out of 4 downregulated circRNAs (circRNA_5801, circRNA_7386 and circRNA_7578) were randomly confirmed by RT-PCR." 1 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. - - circRNA_5901 DOID:0060224 atrial fibrillation atrial fibrillation "RT-qPCR, microarray" up-regulated "All of 4 upregulated circRNAs (circRNA_0031, circRNA_1837, circRNA_5901 and circRNA_7571) and 3 out of 4 downregulated circRNAs (circRNA_5801, circRNA_7386 and circRNA_7579) were randomly confirmed by RT-PCR." 1 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. - - circRNA_7571 DOID:0060224 atrial fibrillation atrial fibrillation "RT-qPCR, microarray" up-regulated "All of 4 upregulated circRNAs (circRNA_0031, circRNA_1837, circRNA_5901 and circRNA_7571) and 3 out of 4 downregulated circRNAs (circRNA_5801, circRNA_7386 and circRNA_7580) were randomly confirmed by RT-PCR." 1 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. - - circRNA_5801 DOID:0060224 atrial fibrillation atrial fibrillation "RT-qPCR, microarray" down-regulated "All of 4 upregulated circRNAs (circRNA_0031, circRNA_1837, circRNA_5901 and circRNA_7571) and 3 out of 4 downregulated circRNAs (circRNA_5801, circRNA_7386 and circRNA_7581) were randomly confirmed by RT-PCR." 1 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. - - circRNA_7386 DOID:0060224 atrial fibrillation atrial fibrillation "RT-qPCR, microarray" down-regulated "All of 4 upregulated circRNAs (circRNA_0031, circRNA_1837, circRNA_5901 and circRNA_7571) and 3 out of 4 downregulated circRNAs (circRNA_5801, circRNA_7386 and circRNA_7582) were randomly confirmed by RT-PCR." 1 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. - - circRNA_7577 DOID:0060224 atrial fibrillation atrial fibrillation "RT-qPCR, microarray" down-regulated "All of 4 upregulated circRNAs (circRNA_0031, circRNA_1837, circRNA_5901 and circRNA_7571) and 3 out of 4 downregulated circRNAs (circRNA_5801, circRNA_7386 and circRNA_7583) were randomly confirmed by RT-PCR." 1 EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1-2 signaling. - hsa_circ_ASAP1 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" up-regulated "CircASAP1 expression was significantly upregulated in recurrent GBM tissues and TMZ-resistant cell lines. CircASAP1 overexpression enhanced GBM cell proliferation and TMZ resistance, which could be reduced by circASAP1 knockdown. Further experiments revealed that circASAP1 increased the expression of NRAS via sponging miR-502-5p. Moreover, circASAP1 depletion effectively restored the sensitivity of TMZ-resistant xenografts to TMZ treatment in vivo." 1 CircATP2B4 promotes hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the miR-223/ATR axis. - hsa_circ_ATP2B4 - DOID:14557 primary pulmonary hypertension pulmonary arterial hypertension RT-qPCR up-regulated CircATP2B4 potentiated hypoxia-induced proliferation and migration of PASMCs through the miR-223/ATR axis. Restoration of the level of miR-223 might be an effective therapeutic method for the treatment of PAH. 2 CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression. - mmu_circ_PAN3 - DOID:936 brain disease ischemia reperfusion injury RT-qPCR down-regulated "Our findings reveal a novel role for circPAN3 in modulating autophagy and apoptosis in myocardial I/R injury and the circPAN3-miR-421-Pink1 axis as a regulatory network, which might provide potential therapeutic targets for cardiovascular diseases." 1 circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion. - hsa_circ_PRKCB - DOID:936 brain disease ischemia reperfusion injury RT-qPCR up-regulated Our findings reveal a crucial role for the circ-PRKCB/miR-339-5p/p66Shc signaling pathway in regulating oxidative stress in the I/R intestine. This pathway may be a potential therapeutic target for intestinal I/R injury. 1 circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis. - hsa_circ_PTCH1 - DOID:4451 renal carcinoma renal carcinoma "RT-qPCR, RNA-seq" up-regulated circPTCH1 promotes RCC metastasis via the miR-485-5p/MMP14 axis and activation of the EMT process. Targeting circPTCH1 may represent a promising therapeutic strategy for metastatic RCC. 1 Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output. - hsa_circ_SCAR - DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" down-regulated Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output. 1 CircARHGAP12 promotes nasopharyngeal carcinoma migration and invasion via ezrin-mediated cytoskeletal remodeling. - hsa_circ_ARHGAP12 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, RNA-seq" up-regulated "circARHGAP12 was found to promote the malignant biological phenotype of NPC via cytoskeletal remodeling, thus providing a clue for targeted therapy of NPC." 1 Circ_0086720 knockdown strengthens the radiosensitivity of non-small cell lung cancer via mediating the miR-375/SPIN1 axis. hsa_circ_0086720 hsa_circ_UBAP2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ_0086720 downregulation enhanced the sensitivity of NSCLC to radiation by regulating the miR-375/SPIN1 axis, contributing to the improvement of the radiotherapies in NSCLC." 1 Circular RNA circ-NCOR2 accelerates papillary thyroid cancer progression by sponging miR-516a-5p to upregulate metastasis-associated protein 2 expression. - hsa_circ_NCOR2 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated Circular RNA circ-NCOR2 accelerates papillary thyroid cancer progression by sponging miR-516a-5p to upregulate metastasis-associated protein 2 expression. 1 Peripheral blood circular RNA hsa_circ_0082688-hsa_circ_0008675 can be used as a candidate biomarker of systemic lupus erythematosus with renal involvement. hsa_circ_0082688 hsa_circ_PARP12 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated "The level of hsa_circ_0082688, hsa_circ_0082689 and hsa_circ_0008675 were significantly elevated in SLE+RI patients with respect to the SLE-RI, RA, NWS patients and the HC. The level of hsa_circ_0082688, hsa_circ_0082689 and hsa_circ_0008675 were associated with C4, anti-dsDNA, anti-nucleosome." 4 Peripheral blood circular RNA hsa_circ_0082688-hsa_circ_0008675 can be used as a candidate biomarker of systemic lupus erythematosus with renal involvement. hsa_circ_0082689 hsa_circ_PARP12 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated "The level of hsa_circ_0082688, hsa_circ_0082689 and hsa_circ_0008675 were significantly elevated in SLE+RI patients with respect to the SLE-RI, RA, NWS patients and the HC. The level of hsa_circ_0082688, hsa_circ_0082689 and hsa_circ_0008675 were associated with C4, anti-dsDNA, anti-nucleosome." 4 Peripheral blood circular RNA hsa_circ_0082688-hsa_circ_0008675 can be used as a candidate biomarker of systemic lupus erythematosus with renal involvement. hsa_circ_0008675 hsa_circ_ZNFX1 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated "The level of hsa_circ_0082688, hsa_circ_0082689 and hsa_circ_0008675 were significantly elevated in SLE+RI patients with respect to the SLE-RI, RA, NWS patients and the HC. The level of hsa_circ_0082688, hsa_circ_0082689 and hsa_circ_0008675 were associated with C4, anti-dsDNA, anti-nucleosome." 1 Circ-ZNF609 Accelerates the Radioresistance of Prostate Cancer Cells by Promoting the Glycolytic Metabolism Through miR-501-3p/HK2 Axis. - hsa_circ_ZNF609 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Circ-ZNF609 promoted the progression and radioresistance of PCa cells through accelerating the glycolysis via miR-501-3p/HK2 axis, providing promising targets for improving the prognosis of PCa patients." 2 "Exosomal Circ-ZNF652 Promotes Cell Proliferation, Migration, Invasion and Glycolysis in Hepatocellular Carcinoma via miR-29a-3p/GUCD1 Axis." - hsa_circ_ZNF652 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Exosomal circ-ZNF652 contributes to HCC cell proliferation, migration, invasion and glycolysis by miR-29a-3p/GUCD1 axis." 2 "CircUBE2D2 (hsa_circ_0005728) promotes cell proliferation, metastasis and chemoresistance in triple-negative breast cancer by regulating miR-512-3p/CDCA3 axis." hsa_circ_0005728 hsa_circ_UBE2D2 - DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated CircUBE2D2 promoted TNBC progression and doxorubicin resistance through acting as a sponge of miR-512-3p to up-regulate CDCA3 expression. Targeting circUBE2D2 combine with doxorubicin might be exploited as a novel therapy for TNBC. 1 Diagnostic value of exosomal circMYC in radioresistant nasopharyngeal carcinoma. - hsa_circ_MYC - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated circMYC is an oncogene in NPC cells and can enhance the radiotherapy resistance of NPC cells. Circulating exosomal circMYC can be used as a potential therapeutic target for NPC. 1 Circular RNA circ_0010283 regulates the viability and migration of oxidized low_density lipoprotein_induced vascular smooth muscle cells via an miR_370_3p/HMGB1 axis in atherosclerosis. hsa_circ_0010283 hsa_circ_UBR4 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated circ_0010283 mediated cell viability and migration via a miR_370_3p/HMGB1 axis in ox_LDL_induced VSMCs. 3 Propofol suppresses gastric cancer tumorigenesis by modulating the circular RNA_PVT1/miR_195_5p/E26 oncogene homolog 1 axis. - hsa_circ_PVT1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "propofol inhibited the proliferation and invasion, but enhanced the apoptosis of GC cells by regulating the circ_PVT1/miR_195_5p/ETS1 axis." 6 Circular RNA circ_HN1 facilitates gastric cancer progression through modulation of the miR-302b-3p/ROCK2 axis. hsa_circ_0045602 hsa_circ_HN1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circ_HN1 exerted an oncogenic role in GC through upregulating ROCK2 via sponging miR-302b-3p, offering evidence that circ_HN1 is a potential target for GC therapy." 4 Silencing circ_0062389 alleviates cardiomyocyte apoptosis in heart failure rats via modulating TGF-beta1/Smad3 signaling pathway. - - circ_0062389 DOID:114 heart disease heart failure RT-qPCR down-regulated "Silencing circ_0062389 could alleviate cardiomyocyte apoptosis in HF rats via modulating TGF-beta1/Smad3 signaling pathway, which might be a promising target for the treatment of HF." 1 TV-circRGPD6 Nanoparticle Suppresses Breast Cancer Stem Cell-Mediated Metastasis via the miR-26b/YAF2 Axis. - hsa_circ_RGPD6 - DOID:1612 breast cancer breast cancer microarray down-regulated "we have developed a TV-circRGPD6 nanoparticle that selectively expresses circRGPD6 in metastatic BCSCs to eradicate breast cancer metastasis, therefore providing a novel avenue to treat breast cancers." 1 Quietness of circular RNA circ_0054633 alleviates the inflammation and proliferation in lipopolysaccharides-induced acute lung injury model through NF-kappaB signaling pathway. hsa_circ_0054633 rno_circ_PNPT1 - DOID:850 lung disease acute lung injury RT-qPCR up-regulated "Quietness of circ_0054633 alleviated LPS-induced ALI via NF-kappaB signaling pathway, implicating circ_0054633 may be a potential biomarker for diagnose and therapy of ALI." 1 CircSFXN1 regulates the behaviour of trophoblasts and likely mediates preeclampsia. - hsa_circ_SFXN1 - DOID:10591 pre-eclampsia preeclampsia "RT-qPCR, microarray" up-regulated "we identified a novel circRNA that regulates tumorigenic activities, suggesting a new pathway governing CircSFXN1/sFLT1-mediated regulation of trophoblast behaviour." 1 Circ_0000079 Decoys the RNA-Binding Protein FXR1 to Interrupt Formation of the FXR1/PRCKI Complex and Decline Their Mediated Cell Invasion and Drug Resistance in NSCLC. hsa_circ_0000079 hsa_circ_USP1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "circ_0000079 might inhibit cell invasion and drug resistance in NSCLC by interrupting the formation of the FXR1/PRCKI complex by interacting with FXR1, and circ_0000079 could act as a potential biomarker and therapeutic target for NSCLC." 1 CircRNA CircRIMS Acts as a MicroRNA Sponge to Promote Gastric Cancer Metastasis. - hsa_circ_RIMS - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated circRIMS has potential as an early biomarker for use in predicting invasive metastasis in GC and to guide clinical diagnosis and treatment for precision medicine. 1 Circular RNA hsa_circ_0001649 suppresses the growth of osteosarcoma cells via sponging multiple miRNAs. hsa_circ_0001649 hsa_circ_SHPRH - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "circ_0001649 worked as a sponge to absorb miR-338-5p, miR-647 and miR-942 to suppress cell proliferation, induce apoptosis and inhibit STAT pathway. Circ_0001649 suppressed OS cell proliferation and STAT pathway and induced apoptosis through sponging miR-338-5p, miR-647 and miR-942." 1 Silencing circular RNA hsa_circ_009755 promotes growth and metastasis of oral squamous cell carcinoma. hsa_circ_009755 - hsa_circ_009755 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "The expression of hsa_circ_009755 was low in OSCC tissues and three OSCC cell lines. Silencing hsa_circ_009755 significantly enhanced the proliferation, migration, and invasion and suppressed the apoptosis of OSCC cells." 2 Circular RNA CircITGA7 Promotes Tumorigenesis of Osteosarcoma via miR-370/PIM1 Axis. hsa_circ_0004840 hsa_circ_TGA7 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circITGA7 promotes OS proliferation and metastasis via miR-370/PIM1. 1 circKMT2D contributes to H(2)O(2)-attenuated osteosarcoma progression via the miR-210/autophagy pathway. - hsa_circ_KMT2D - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated these findings indicated that circKMT2D knockdown may contribute to the inhibition of H(2)O(2)-attenuated OS progression via miR-210/autophagy pathway. 1 Circular RNA GLIS2 promotes colorectal cancer cell motility via activation of the NF-kappaB pathway. - hsa_circ_GLIS2 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "our study reveals that circGLIS2, acting as a potential oncogene, maintains the abnormal activation state of the NF-kappaB signaling pathway via the miR-671 sponge mechanism in CRC cells. This study provides a scientific basis for targeting circGLIS2 in colorectal cancer interventions." 1 "CircZNF609 promotes cell proliferation, migration, invasion, and glycolysis in nasopharyngeal carcinoma through regulating HRAS via miR-338-3p." - hsa_circ_ZNF609 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "circZNF609 acted as a competing endogenous RNA of miR-338-3p to regulate HRAS. CircZNF609 knockdown suppressed cell tumorigenesis in NPC via regulating miR-338-3p/HRAS axis, suggesting a novel therapeutic strategy for NPC." 5 Upregulation of circ_0000142 promotes multiple myeloma progression by adsorbing miR-610 and upregulating AKT3 expression. hsa_circ_0000142 hsa_circ_CCT3 - DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated "circ_0000142 functioned as a competitive endogenous RNA, directly targeting miR-610 and positively regulating AKT3 expression. In brief, circ_0000142 enhances the proliferation and metastasis of MM cells by modulating the miR-610/AKT3 axis." 1 Upregulated hsa_circ_0005785 Facilitates Cell Growth and Metastasis of Hepatocellular Carcinoma Through the miR-578/APRIL Axis. hsa_circ_0005785 hsa_circ_ANAPC7 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "our current study revealed an oncogenic role of hsa_circ_0005785 in the tumorigenesis of HCC. Moreover, targeting to the hsa_circ_0005785/miR-578/APRIL regulatory pathway might be a promising diagnostic and therapeutic strategy for HCC clinical practice." 2 Downregulation of hsa_circ_0000936 sensitizes resistant glioma cells to temozolomide by sponging miR-1294. hsa_circ_0000936 hsa_circ_SHKBP1 - DOID:0060108 brain glioma glioma RT-qPCR down-regulated "downregulation of hsa_circ_0000936 sensitizes TMZ-resistant glioma cells to TMZ by sponging miR-1294, suggesting that hsa_circ_0000936 may be a potential target for overcoming the resistance of glioma cells to TMZ." 2 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0083920 hsa_circ_UNC5D - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" up-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0062558 hsa_circ_MMP11 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" up-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0020376 hsa_circ_ADAM12 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" up-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0056686 hsa_circ_KIF5C - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" up-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 2 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0006571 hsa_circ_SATB2 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" up-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0016628 hsa_circ_DNAH14 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" up-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0046674 hsa_circ_TYMS - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" up-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0084859 hsa_circ_MMP16 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" up-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0039985 hsa_circ_CDH3 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" up-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0020786 hsa_circ_TCONS_00063837_H19 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" up-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0043579 hsa_circ_TMEM99 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" down-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0026353 hsa_circ_NR4A1 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" down-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0015729 hsa_circ_PTGS2 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" down-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0081566 hsa_circ_SERPINE1 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" down-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0087207 hsa_circ_ALDH1A1 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" down-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0030979 hsa_circ_F10 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" down-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0066135 hsa_circ_ITIH3 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" down-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0076808 hsa_circ_COL21A1 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" down-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0020068 hsa_circ_ABLIM1 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" down-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma. hsa_circ_0054660 hsa_circ_EFEMP1 - DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma "RT-qPCR, microarray" down-regulated Bioinformatics analysis suggested that most differentially expressed circRNAs participate in pathways were related to pathological processes of ULM. 1 Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF-kappaB activation. hsa_circ_0060745 - circ_0060745 DOID:9408 acute myocardial infarction acute myocardial infarction (AMI) RT-qPCR up-regulated knockdown of circ_0060745 mitigates AMI by suppressing cardiomyocyte apoptosis and inflammation 1 A Circle RNA Regulatory Axis Promotes Lung Squamous Metastasis via CDR1-Mediated Regulation of Golgi Trafficking. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:3907 lung squamous cell carcinoma lung squamous cell carcinoma RT-qPCR up-regulated "This study shows that circRNA, CDR1as, promotes lung squamous migration, metastasis, and Golgi trafficking through its complimentary transcript, CDR1." 1 circKIF4A sponges miR-127 to promote ovarian cancer progression. - hsa_circ_KIF4A - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated circKIF4A acted as a competitive endogenous RNA (ceRNA) to promoted ovarian cancer progression by sponging miR-127 and upregulated the expression of Junctional adhesion molecule 3 (JAM3). 1 Circular RNA PVT1 promotes the invasion and epithelial-mesenchymal transition of breast cancer cells through serving as a competing endogenous RNA for miR-204-5p. hsa_circ_0085539 hsa_circ_PVT1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Collectively, this study provides the first link between circPVT1 expression and BCa development. We found that circPVT1 was upregulated in BCa, and its upregulation might promote the invasion and EMT of BCa cells by serving as a ceRNA for miR-204-5p. Therefore, circPVT1 might be a potential diagnostic biomarker and therapeutic target for BCa patients." 4 circKRT7-miR-29a-3p-COL1A1 Axis Promotes Ovarian Cancer Cell Progression. - hsa_circ_KRT7 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated circKRT7 promotes EMT-related cell progression by absorbing miR-29a-3p in ovarian cancer. This suggests the crucial role of circular RNA in the malignant evolution in cancer. 1 Circular RNA circNELL2 Acts as the Sponge of miR-127-5p to Promote Esophageal Squamous Cell Carcinoma Progression. hsa_circ_0025933 hsa_circ_NELL2 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "circNELL2 promoted the progression of ESCC cells via sponging miR-127-5p, and it has the potential to serve as a novel prognostic and therapeutic target for ESCC." 2 Interference of Hsa_circ_0003928 Alleviates High Glucose-Induced Cell Apoptosis and Inflammation in HK-2 Cells via miR-151-3p/Anxa2. hsa_circ_0003928 hsa_circ_TAOK1 - DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated hsa_circ_0003928 could act as a sponge of miR-151-3p and regulate HG-induced inflammation and apoptosis partly through regulating Anxa2. 3 "CircFLNA Acts as a Sponge of miR-646 to Facilitate the Proliferation, Metastasis, Glycolysis, and Apoptosis Inhibition of Gastric Cancer by Targeting PFKFB2." - hsa_circ_FLNA - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "CircFLNA Acts as a Sponge of miR-646 to Facilitate the Proliferation, Metastasis, Glycolysis, and Apoptosis Inhibition of Gastric Cancer by Targeting PFKFB2." 2 CircTTBK2 Contributes to the Progression of Glioma Through Regulating miR-145-5p/CPEB4 Axis. - hsa_circ_TTBK2 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "CircTTBK2 functioned as a tumor promoter in glioma by modulating miR-145-5p/CPEB4 axis, which might offer a new sight for glioma therapy." 4 Circular RNA hsa_circ_0003496 Contributes to Tumorigenesis and Chemoresistance in Osteosarcoma Through Targeting (microRNA) miR-370/Kruppel-Like Factor 12 Axis. hsa_circ_0003496 hsa_circ_UBAP2 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Our present work suggested that the knockdown of circ_0003496 suppressed OS progression and enhanced DXR sensitivity at least partially through modulating KLF12 expression via functioning as a miR-370 sponge, highlighting new opportunities for OS management." 5 CircRNA Circ_0001721 Promotes the Progression of Osteosarcoma Through miR-372-3p/MAPK7 Axis. hsa_circ_0001721 hsa_circ_CDK14 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Knockdown of circ_0001721 inhibited glycolysis, cell proliferation, cell migration, invasion and epithelial-to-mesenchymal transition (EMT), and promoted apoptosis." 5 Circ_0007031 Serves as a Sponge of miR-760 to Regulate the Growth and Chemoradiotherapy Resistance of Colorectal Cancer via Regulating DCP1A. hsa_circ_0007031 hsa_circ_TUBGCP3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0007031 might play a positive role in the CRR of CRC through regulating the miR-760/DCP1A axis, which might provide a new approach for treating the CRR of CRC." 4 Downregulation of circRNA_0000285 Suppresses Cervical Cancer Development by Regulating miR197-3p-ELK1 Axis. hsa_circ_0000285 hsa_circ_HIPK3 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Knockdown of circ_0000285 reduced xenograft tumor growth in vivo. CONCLUSION: Knockdown of circ_0000285 repressed CC development by increasing miR197-3p and decreasing ELK1. 4 "Circular RNA circ-0016068 Promotes the Growth, Migration, and Invasion of Prostate Cancer Cells by Regulating the miR-330-3p/BMI-1 Axis as a Competing Endogenous RNA." hsa_circ_0016068 hsa_circ_BTG2 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated circ-0016068 may be a promising diagnostic biomarker for early stage prostate cancer and a potential target for novel cancer therapeutics. 1 "Circular RNA PRKCI and microRNA-545 relate to sepsis risk, disease severity and 28-day mortality." - hsa_circ_PRKCI - DOID:0040085 bacterial sepsis sepsis RT-qPCR down-regulated "circ-PRCKI insufficiency and miR-545 sufficiency were related to sepsis risk, clinical disease severity and 28-day mortality risk." 1 Hsa_circ_0000231 knockdown inhibits the glycolysis and progression of colorectal cancer cells by regulating miR-502-5p/MYO6 axis. hsa_circ_0000231 hsa_circ_ARHGAP12 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Hsa_circ_0000231 knockdown inhibited CRC progression and glycolysis by downregulating MYO6 expression through sponging miR-502-5p, which might provide a theoretical basis in further studying circ_0000231-directed therapy in CRC." 2 CircFOXP1/FOXP1 promotes osteogenic differentiation in adipose-derived mesenchymal stem cells and bone regeneration in osteoporosis via miR-33a-5p. - hsa_circ_FOXP1 - DOID:11476 osteoporosis osteoporosis "RT-qPCR, microarray" down-regulated This research found that circFOXP1 was significantly down-regulated in OP patient bone tissues and functioned like a miRNA sponge targeting miR-33a-5p to increase FOXP1 expression. 1 Restoration of circPSMC3 sensitizes gefitinib-resistant esophageal squamous cell carcinoma cells to gefitinib by regulating miR-10a-5p/PTEN axis. - hsa_circ_PSMC3 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR down-regulated "upregulation of circPSMC3 overcame resistance of GR ESCC cells to gefitinib by modulating the miR-10a-5p/PTEN axis, which provide a new therapeutic strategy for overcoming gefitinib resistance in ESCC." 1 Silencing circRNA_001937 may inhibit cutaneous squamous cell carcinoma proliferation and induce apoptosis by preventing the sponging of the miRNA_597_3p/FOSL2 pathway. - - circRNA_001937 DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma "RT-qPCR, microarray" up-regulated circRNA_001937 expression was increased in CSCC and silencing circRNA_001937 gene expression may inhibit CSCC progression by sponging the miRNA_597_3p/FOSL2 pathway. 1 Expression and clinical significance of circular RNA hsa_circ_0079787 in the peripheral blood of patients with axial spondyloarthritis. hsa_circ_0079787 hsa_circ_DPY19L1P1 - DOID:848 arthritis axial spondyloarthritis RT-qPCR down-regulated "peripheral_blood hsa_circ_0079787 and the combination of hsa_circ_0079787_PLT_MPV_PCT may provide improved diagnostic accuracy for AxSpA. In addition, the levels of hsa_circ_0079787 in the peripheral blood were correlated with disease activity and severity of AxSpA." 1 Circ-CUX1 Accelerates the Progression of Neuroblastoma via miR-16-5p/DMRT2 Axis. - hsa_circ_CUX1 - DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated "circ-CUX1 accelerated the proliferation, migration, invasion and glycolysis of NB cells through targeting miR-16-5p/DMRT2 signaling cascade." 3 CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures. - mmu_circ_Hivep2 - DOID:1826 epilepsy epilepsy microarray down-regulated "circHivep2 regulates microglia activation in the progression of epilepsy by interfering with miR-181a-5p to promote SOCS2 expression, indicating that circHivep2 may serve as a therapeutic tool to prevent the development of epilepsy." 1 Circular RNA Encoded Amyloid Beta peptides-A Novel Putative Player in Alzheimer Disease. hsa_circ_0007556 hsa_circ_APP - DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated "circAbeta-a and its corresponding translation product could potentially represent novel therapeutic targets for AD treatment. Importantly, our data point to yet another evolutionary route for potentially increasing proteome complexity by generating additional polypeptide variants using back-splicing of primary transcripts that yield circular RNA templates." 1 Exosomal Circ-MEMO1 Promotes the Progression and Aerobic Glycolysis of Non-small Cell Lung Cancer Through Targeting MiR-101-3p/KRAS Axis. - hsa_circ_MEMO1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Exosomal Circ-MEMO1 Promotes the Progression and Aerobic Glycolysis of Non-small Cell Lung Cancer Through Targeting MiR-101-3p/KRAS Axis. 3 Circular RNA CircHIPK3 Elevates CCND2 Expression and Promotes Cell Proliferation and Invasion Through miR-124 in Glioma. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated circHIPK3 had carcinogenic effects by regulating the expression of CCND2 in glioma by sponging miR-124. These findings provided favorable evidence to reveal the role of circHIPK3 in the development of gliomas. 7 CircEXOC6B Suppresses the Proliferation and Motility and Sensitizes Ovarian Cancer Cells to Paclitaxel Through miR-376c-3p/FOXO3 Axis. - hsa_circ_EXOC6B - DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "CircEXOC6B suppressed the progression and PTX resistance of ovarian cancer cells through sequestering miR-376c-3p, thus enhancing FOXO3 level." 2 Circular RNA circ_C16orf62 Suppresses Cell Growth in Gastric Cancer by miR-421/Tubulin beta-2A Chain (TUBB2A) Axis. - hsa_circ_C16orf62 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "circ_C16orf62 impeded proliferation, migration, and invasion in vitro and retarded tumor growth in vivo by the miR-421/TUBB2A axis in GC, providing a potential therapeutic strategy for patients with GC." 1 Circ_0010729 regulates hypoxia-induced cardiomyocyte injuries by activating TRAF5 via sponging miR-27a-3p. hsa_circ_0010729 - Circ_0010729 DOID:114 heart disease hypoxia-induced cardiomyocyte injuries RT-qPCR up-regulated circ_0010729 knockdown alleviated hypoxia-induced AC16 cell injuries by mediating the miR-27a-3p/TRAF5 axis. 1 circHIPK3 Acts as Competing Endogenous RNA and Promotes Non-Small-Cell Lung Cancer Progression through the miR-107/BDNF Signaling Pathway. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circHIPK3 promotes tumor progression through a new circHIPK3/miR-107/BDNF axis, which offers potential markers and medical treatment for NSCLC." 4 The circular RNA circPTK2 inhibits EMT in hepatocellular carcinoma by acting as a ceRNA and sponging miR-92a to upregulate E-cadherin. - hsa_circ_PTK2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Overexpression of miR-92a enhanced cell proliferation and invasion by targeting the E-cadherin 3UTR in HCC cells. Furthermore, we found that circPTK2 inhibited EMT by inhibiting miR-92a, preventing its ability to downregulate E-cadherin in HCC cells." 1 Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis. hsa_circ_0020394 hsa_circ_DOCK1 circ_0020394 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "Puerarin impedes cell viability, migration, invasion, and glycolysis, and promoted apoptosis in bladder cancer by regulating circ_0020394/miR-328-3p/NRBP1 axis." 2 "Circular RNA circABCC4 acts as a ceRNA of miR-154-5p to improve cell viability, migration and invasion of breast cancer cells in vitro." - hsa_circ_ABCC4 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "CircABCC4 knockdown repressed breast cancer cells viability, migration, and invasion by up-regulating miR-154-5p via inhibiting NF-kappaB and Wnt/beta-catenin signal pathways." 1 Circular RNA hsa_circ_0005556 Accelerates Gastric Cancer Progression by Sponging miR-4270 to Increase MMP19 Expression. hsa_circ_0005556 hsa_circ_NBAS - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Our study shows that the hsa_circ_0005556/miR-4270/MMP19 axis is involved in proliferation, migration, and invasion of gastric cancer cells through the competing endogenous RNA (ceRNA) mechanism." 3 Circ-HIPK2 Accelerates Cell Apoptosis and Autophagy in Myocardial Oxidative Injury by Sponging miR-485-5p and Targeting ATG101. - mmu_circ_HIPK2 - DOID:1287 cardiovascular system disease myocardial injury RT-qPCR up-regulated "circ-HIPK2 facilitates autophagy to accelerate cell apoptosis and cell death in H2O2-caused myocardial oxidative injury through the miR-485-5p/ATG101 pathway, indicating a novel therapeutic target point for patients with myocardial injury." 1 CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-kappaB axis. - - CircRNA_09505 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-kappaB axis. 1 "circSMARCA5 Promoted Osteosarcoma Cell Proliferation, Adhesion, Migration, and Invasion through a Competing Endogenous RNA Network." - hsa_circ_SMARCA5 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circSMARCA5 was an oncogene in OS by inducing cancer cell proliferation, adhesion, migration, and invasion. Mechanically, circSMARCA5 could sponge various OS growth- and metastasis-related miRNAs, including microRNA-432 and miR-181c." 1 CircRNA ITCH increases bortezomib sensitivity through regulating the miR-615-3p/PRKCD axis in multiple myeloma. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:9538 multiple myeloma multiple myeloma RT-qPCR down-regulated "circITCH overexpression enhanced the sensitivity of MM cells to BTZ through miR-615-3p/PRKCD axis, providing a novel potential target for combating BTZ resistance in patients with MM." 1 CircDENND2A Promotes Non-small Cell Lung Cancer Progression via Regulating MiR-34a/CCNE1 Signaling. - hsa_circ_DENND2A - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated CircDENND2A Promotes Non-small Cell Lung Cancer Progression via Regulating MiR-34a/CCNE1 Signaling. 1 "Circular RNA circ-102,166 acts as a sponge of miR-182 and miR-184 to suppress hepatocellular carcinoma proliferation and invasion." - - "circ-102,166" DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq, microarray" down-regulated "Our data revealed a tumor-suppressing role of circ-102,166 in HCC. Down-regulation of circ-102,166 enhanced the proliferation and invasion of HCC cells by releasing the oncomiRs miR-182 and miR-184." 1 Circular RNA CircCDH13 contributes to the pathogenesis of osteoarthritis via CircCDH13/miR-296-3p/PTEN axis. - hsa_circ_CDH13 - DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" up-regulated "Silencing of CircCDH13 could reduce chondrocyte apoptosis, inhibit ECM catabolism, and promote ECM anabolism through the miR-296-3p-PTEN pathway. It provides a potential target for developing effective interventions in treating OA." 1 Circ_0091581 Promotes the Progression of Hepatocellular Carcinoma Through Targeting miR-591/FOSL2 Axis. hsa_circ_0091581 - circ_0091581 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0091581 acted as an oncogene to enhance the viability, colony formation, metastasis and cell cycle and inhibit the apoptosis of HCC cells through targeting miR-591/FOSL2 axis." 2 "Circ_0000285 regulates proliferation, migration, invasion and apoptosis of osteosarcoma by miR-409-3p/IGFBP3 axis." hsa_circ_0000285 - circ_0000285 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circ_0000285 regulated proliferation, migration, invasion and apoptosis of OS cells by miR-409-3p/IGFBP3 axis, implying that circ_0000285 was a potential target for OS therapy." 2 The novel circ_0028171/miR-218-5p/IKBKB axis promotes osteosarcoma cancer progression. hsa_circ_0028171 - circ_0028171 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "circ_0028171 might promote the malignant behavior of OS tissues through miR-218-5p/IKBKB axis, which could be a potential novel marker for early diagnosis of OS." 1 Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus. - hsa_circ_PPM1F - DOID:9744 type 1 diabetes mellitus type 1 diabetes mellitus RT-qPCR up-regulated Overexpression of circPPM1F could promote pancreatic islet injury by enhancing M1 macrophage activation and circPPM1F may serve as a novel potential therapeutic target for T1DM in children. 1 Overexpression of circRNA chr7:154954255-154998784+ in cancer-associated pancreatic stellate cells promotes the growth and metastasis of pancreatic cancer by targeting the miR-4459/KIAA0513 axis. - - chr7:154954255-154998784+ DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, RNA-seq" up-regulated Chr7:154954255-154998784+ may promote the development of pancreatic cancer through the miR-4459/KIAA0513 axis in CaPSCs and may be an important therapeutic target for patients with pancreatic cancer in the future. 1 "Circ_0000043 promotes the proliferation, migration, invasiveness, and epithelial-mesenchymal transition in breast cancer cells via the miR-136-Smad3 axis." hsa_circ_0000043 - circ_0000043 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_0000043 promotes the proliferation, migration, invasiveness, and epithelial-mesenchymal transition in breast cancer cells via the miR-136-Smad3 axis." 1 "Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration, and invasion by regulating MAPK pathway." hsa_circ_0003204 hsa_circ_USP36 - DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" up-regulated "Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration, and invasion by regulating MAPK pathway." 1 Circular RNA 0086996 regulates growth and migration of osteosarcoma cells via miR-125b-5p. hsa_circ_0086996 hsa_circ_RECK - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ_0086996 acts as miR-125b-5p sponge to mediate the tumorigenicity, which could act as a potential biomarker for the osteosarcoma and provides a novel insight for the mechanism in osteosarcoma." 1 "Circular RNA hsa_circ_0001785 inhibits the proliferation, migration and invasion of breast cancer cells in vitro and in vivo by sponging miR-942 to upregulate SOCS3." hsa_circ_0001785 hsa_circ_ELP3 - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "circ_0001785 has low expression in BC. Circ_0001785 overexpression significantly inhibited cell proliferation, migration/invasion and the tumor growth. " 3 circRNA circ-MYBL2 is a novel tumor suppressor and potential biomarker in multiple myeloma. - hsa_circ_MYBL2 - DOID:9538 multiple myeloma multiple myeloma RT-qPCR down-regulated circ-MYBL2 affects the post-translational modification of its host protein through acting as a protein-binding partner of Cyclin F. 1 "Cir-ITCH inhibits gastric cancer migration, invasion and proliferation by regulating the Wnt/beta-catenin pathway." - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated cir-ITCH was shown to prevent gastric cancer tumourgenesis through the Wnt/beta-catenin signalling pathway by sequestering miR-17. 3 Circular RNA Hsa_circ_0004018 Inhibits Wnt/beta-Catenin Signaling Pathway by Targeting microRNA-626/DKK3 in Hepatocellular Carcinoma. hsa_circ_0004018 hsa_circ_SMYD4 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated We revealed that hsa_circ_0004018/miR-626/DKK3 regulatory axis may be a possible novel therapeutic target for HCC. 3 Circ_0006528 Contributes to Paclitaxel Resistance of Breast Cancer Cells by Regulating miR-1299/CDK8 Axis. hsa_circ_0006528 - circ_0006528 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0006528 partially contributed to PTX resistance of breast cancer cells through up-regulating CDK8 expression by sponging miR-1299. 4 Downregulation of circNRIP1 Suppresses the Paclitaxel Resistance of Ovarian Cancer via Regulating the miR-211-5p/HOXC8 Axis. - hsa_circ_NRIP1 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "CircNRIP1 silencing could inhibit the PTX resistance of OC via regulating the miR-211-5p/HOXC8 axis, showing that circNRIP1 might be a potential target for OC resistance treatment." 2 Gambogic Acid Inhibits the Progression of Gastric Cancer via circRNA_ASAP2/miR-33a-5p/CDK7 Axis. - hsa_circ_ASAP2 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Circ_ASAP2 overexpression promoted cell proliferation, migration and invasion, whereas inhibited cell apoptosis by upregulating CDK7 expression through binding to miR-33a-5p in GA-induced GC cells. This study provided a theoretical basis in GC treatment with GA." 3 Circ_0084927 Facilitates Cervical Cancer Development via Sponging miR-142-3p and Upregulating ARL2. hsa_circ_0084927 - circ_0084927 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Circ_0084927 accelerated the progression of cervical cancer partly by mediating the miR-142-3p/ARL2 axis. 3 CircCFL1/MiR-107 Axis Targeting HMGB1 Promotes the Malignant Progression of Diffuse Large B-Cell Lymphoma Tumors. - hsa_circ_CFL1 - DOID:0050745 diffuse large B-cell lymphoma diffuse large b-cell lymphoma RT-qPCR up-regulated circRNA CircCFL1 could regulate the expression of HMGB1 through miR-107 to promote the proliferation and migration of DLBCL. 1 Hsa_circ_0084927 Regulates Cervical Cancer Advancement via Regulation of the miR-634/TPD52 Axis. hsa_circ_0084927 hsa_circ_ESRP1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Hsa_circ_0084927 accelerated CC advancement via upregulating TPD52 via sponging miR-634, offering a new evidence to support hsa_circ_0084927 as a promising target for CC treatment." 3 Circ_0058124 Aggravates the Progression of Papillary Thyroid Carcinoma by Activating LMO4 Expression via Targeting miR-370-3p. hsa_circ_0058124 - circ_0058124 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "Circ_0058124 promoted the development of PTC by mediating the miR-370-3p/LMO4 axis, and circ_0058124, functioned as an oncogene in PTC, might be used as a promising biomarker for PTC diagnosis and treatment." 2 CircCSNK1G1 Contributes to the Development of Colorectal Cancer by Increasing the Expression of MYO6 via Competitively Targeting miR-455-3p. - hsa_circ_CSNK1G1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "CircCSNK1G1 participated in the progression of CRC partly by modulating the miR-455-3p/MYO6 network, which provided a theoretical basis for circCSNK1G1 involving in CRC pathogenesis, hinting that circCSNK1G1 might be a useful biomarker for CRC treatment." 2 CircNFIX Acts as a miR-212-3p Sponge to Enhance the Malignant Progression of Non-Small Cell Lung Cancer by Up-Regulating ADAM10. - hsa_circ_NFIX - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our findings first identified that the knockdown of circNFIX, a highly expressed circRNA in NSCLC, exerted a repressive role in NSCLC malignant progression at least in part through targeting the miR-212-3p/ADAM10 axis, illuminating a novel understanding of circRNA regulation in NSCLC." 1 "Circ_0072088 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Cancer by Absorbing miR-377." hsa_circ_0072088 - circ_0072088 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "circ_0072088 upregulated VEGF gene expression by acting as the sponge of miRNA-377. In conclusion, circ_0072088 might be used as a diagnostic biomarker and therapeutic target for ESCC." 1 Circ-Tulp4 promotes beta-cell adaptation to lipotoxicity by regulating soat1 expression. - mmu_circ_Tulp4 - DOID:9351 diabetes mellitus diabetes "RT-qPCR, RNA-seq" down-regulated "circ-Tulp4 might be a potential therapeutic intervention for T2DM. Besides, soat1 might be important for beta-cell adaptation to lipotoxicity." 1 CircCPA4 Promotes the Malignant Phenotypes in Glioma via miR-760/MEF2D Axis. - hsa_circ_CPA4 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circCPA4 knockdown suppressed cell malignant phenotypes in glioma via miR-760/MEF2D axis to impede the progression of glioma, suggesting potential therapeutic targets for glioma treatment." 3 The Regulation of circRNA RNF13/miRNA-1224-5p Axis Promotes the Malignant Evolution in Acute Myeloid Leukemia. - hsa_circ_RNF13 - DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR down-regulated "CircRNF13 inhibited the proliferation, migration, and invasion of AML cells by regulating the expression of miRNA-1224-5p. This study provides some clues for the diagnosis and treatment of AML." 1 Circular RNA hsa_circ_0102231 sponges miR-145 to promote non-small cell lung cancer cell proliferation by up-regulating the expression of RBBP4. hsa_circ_0102231 - - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "hsa_circ_0102231 promotes proliferation and invasion by mediating the miR-145/RBBP4 axis in NSCLC, indicating that it might be a potential target for NSCLC treatment." 1 Circular RNA SMARCA5 suppressed non-small cell lung cancer progression by regulating miR-670-5p/RBM24 axis. - hsa_circ_sSMARCA5 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "circsSMARCA5 may serve as an NSCLC suppressor by regulating the miR-670-5p/RBM24 axis, and it may have the potential to be a biomarker or therapeutic target for NSCLC." 1 CircRNA EPHB4 modulates stem properties and proliferation of gliomas via sponging miR-637 and up-regulating SOX10. hsa_circ_0081519 hsa_circ_EPHB4 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "the circEPHB4/miR-637/SOX10/Nestin axis plays a central role in controlling stem properties, self-renewal and glycolysis of glioma cells and predicts the overall survival of glioma patients. Targeting this axis might provide a therapeutic strategy for malignant gliomas." 3 Circular RNA MTO1 inhibits gastric cancer progression by elevating PAWR via sponging miR-199a-3p. - hsa_circ_MTO1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "circMTO1 can regulate the growth of gastric cancer cells by regulating miR-199a-3p/PAWR axis, thus inhibiting the development and progression of gastric cance." 3 Circ_0000215 Increases the Expression of CXCR2 and Promoted the Progression of Glioma Cells by Sponging miR-495-3p. hsa_circ_0000215 - circ_0000215 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "miR-495-3p targeted CXCR2 and negatively regulated CXCR2/PI3K/Akt pathway. However, the effects of miR-495-3p were all dampened by overexpression of circ_0000215. CONCLUSION: These data demonstrated that circ_0000215 functions as a competitive endogenous RNA by sponging miR-495-3p, thus accelerating glioma progression through CXCR2 axis." 1 Identification of circ_0085616 as an Upregulated and Oncogenic Circular RNA in Cervical Cancer Via the miR-503-5p-Mediated ATXN7L3 Activation. hsa_circ_0085616 - circ_0085616 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circ_0085616 facilitated the carcinogenic effect on CC via the activation of ATXN7L3 by sponging miR-503-5p. Our study may be likely to provide a novel molecular target for CC therapy. 2 Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients. hsa_circ_0072391 hsa_circ_HMGCS1 - DOID:288 endometriosis of uterus endometriosis "RT-qPCR, RNA-seq, microarray" up-regulated "Hsa_circ_0072391, hsa_circ_0007299 and hsa_circ_0057799 were significantly increased, and hsa_circ_001533 was significantly decreased in endometriosis-associated infertility patients." 1 Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients. hsa_circ_0007299 hsa_circ_CYP51A1 - DOID:288 endometriosis of uterus endometriosis "RT-qPCR, RNA-seq, microarray" up-regulated "Hsa_circ_0072391, hsa_circ_0007299 and hsa_circ_0057799 were significantly increased, and hsa_circ_001534 was significantly decreased in endometriosis-associated infertility patients." 1 Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients. hsa_circ_0057799 hsa_circ_BMPR2 - DOID:288 endometriosis of uterus endometriosis "RT-qPCR, RNA-seq, microarray" up-regulated "Hsa_circ_0072391, hsa_circ_0007299 and hsa_circ_0057799 were significantly increased, and hsa_circ_001535 was significantly decreased in endometriosis-associated infertility patients." 1 Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients. hsa_circ_0001599 hsa_circ_FKBP5 - DOID:288 endometriosis of uterus endometriosis "RT-qPCR, RNA-seq, microarray" down-regulated "Hsa_circ_0072391, hsa_circ_0007299 and hsa_circ_0057799 were significantly increased, and hsa_circ_001536 was significantly decreased in endometriosis-associated infertility patients." 1 Circular RNA 0001273 in exosomes derived from human umbilical cord mesenchymal stem cells (UMSCs) in myocardial infarction. hsa_circ_0001273 - circ-0001273 DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated "Circ-0001273 can remarkably inhibit the occurrence of myocardial cell apoptosis in ischemic environment, promote MI repair, and provide a good reference for clinical treatment." 1 "circ_SEPT9, a newly identified circular RNA, promotes oral squamous cell carcinoma progression through miR-1225/PKN2 axis." - hsa_circ_SEPT9 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "circ_SEPT9, a newly identified circular RNA, promotes oral squamous cell carcinoma progression through miR-1225/PKN2 axis." 1 Circ-XPO1 upregulates XPO1 expression by sponging multiple miRNAs to facilitate osteosarcoma cell progression. - hsa_circ_XPO1 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "circ-XPO1 regulated the expression of XPO1 through sponging miRNAs as a competing endogenous (ceRNA), providing the possibility that circ-XPO1 might play as a new therapeutic target for OS." 2 CircSERPINE2 weakens IL-1beta-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis. - hsa_circ_SERPINE2 - DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "circSERPINE2 attenuated IL-1beta-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis, indicating a new target for OA treatment." 2 Circular RNA Circ_ANKMY2 Regulates Temporal Lobe Epilepsy Progression via the miR-106b-5p/FOXP1 Axis. - hsa_circ_ANKMY2 - DOID:1826 epilepsy epilepsy RT-qPCR up-regulated "circ_ANKMY2 modulated TLE advancement via regulation of FOXP1 expression through sponging miR-106b-5p, and circ_ANKMY2 might be an underlying target for the improvement of TLE." 1 Circular RNA hsa_circ_0000282 contributes to osteosarcoma cell proliferation by regulating miR-192/XIAP axis. hsa_circ_0000282 hsa_circ_METTL15 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circ_0000282 was a novel oncogenic circRNA in OSA. Circ_0000282/miR-192/XIAP axis regulated OSA cell proliferation apoptosis with competitive endogenous RNA mechanism. 1 Circular RNA THBS1 promotes proliferation and apoptosis of non-small cell lung cancer cells by sponging miR-129-5p and regulating SOX4 expression. - hsa_circ_THBS1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated CircTHBS1 promotes the proliferation and inhibits the apoptosis of NSCLC cells through targeting miR-129-5p and regulating SOX4 expression. 1 Circular RNA Involved in the Protective Effect of Malva sylvestris L. on Myocardial Ischemic/Re-Perfused Injury. - - circ003593 DOID:114 heart disease ischemic heart disease "RT-qPCR, microarray" up-regulated circRNA circ003593-mediated the protective role of MS through NLRP3 inflammasome. Circ003593 may serve as a potential therapeutic target for ischemic heart diseases. 1 Circular RNA circ_0000039 enhances gastric cancer progression through miR-1292-5p/DEK axis. hsa_circ_0000039 hsa_circ_YTHDF2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Circ_0000039 is a new oncogenic circRNA in GC, which regulates the miR-1292-5p/DEK axis to modulate the malignant biological behaviors of GC." 1 CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc. hsa_circ_0002402 hsa_circ_ECE1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated CircECE1 regulates the Warburg effect through the c-Myc/TXNIP axis. CircECE1 mediated signal transduction plays a important role in OS process and energy metabolism. These findings may identify novel targets for OS molecular therapy. 2 Tobacco-Related Exposure Upregulates Circ_0035266 to Exacerbate Inflammatory Responses in Human Bronchial Epithelial Cells. hsa_circ_0035266 - - DOID:552 pneumonia pneumonia RT-qPCR up-regulated "circ_0035266 served as a competitive endogenous RNA for miR-181d-5p to regulate DDX3X expression, which is involved in the modulation of NNK+LPS-induced inflammatory responses in BEAS-2B cells." 1 CircTET1 Inhibits Retinoblastoma Progression via Targeting miR-492 and miR-494-3p through Wnt/beta-catenin Signaling Pathway. hsa_circ_0093996 hsa_circ_TET1 - DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated "CircTET1 inhibited RB progression by sponging miR-492/miR-494-3p and inactivating the Wnt/beta-catenin pathway, which provided new insights for RB treatment." 2 circCRAMP1L is a novel biomarker of preeclampsia risk and may play a role in preeclampsia pathogenesis via regulation of the MSP/RON axis in trophoblasts. - hsa_circ_CRAMP1L - DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "Reduced plasma levels of circCRAMP1L may be associated with an increased risk of preeclampsia, and circCRAMP1L may be a novel biomarker of preeclampsia risk." 1 Circular RNA circ_PVT1 induces epithelial-mesenchymal transition to promote metastasis of cervical cancer. hsa_circ_0009143 hsa_circ_PVT1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circRNA_PVT1 can induce EMT of cervical cancer cells via targeting miR-1286 by exosome pathway, which can be a novel mechanism of cervical cancer progression." 1 circ_001504 promotes the development of renal cell carcinoma by sponging microRNA-149 to increase NUCB2. - - circ_001504 DOID:4451 renal carcinoma renal carcinoma "RT-qPCR, microarray" up-regulated "reduced expression of circ_001504 lowered NUCB2 expression by sponging miR-149, thereby attenuating RCC progression, providing insight into circ_001504/miR-149/NUCB2 feedback loop into RCC treatment." 1 Comprehensive Assessment of Plasma Circ_0004771 as a Novel Diagnostic and Dynamic Monitoring Biomarker in Gastric Cancer. hsa_circ_0004771 hsa_circ_NRIP1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated "Plasma circ_0004771 is differentially expressed in GC patients, postoperative GC patients and patients with recurrence, suggesting that plasma circ_0004771 can be used as a novel diagnostic and dynamic monitoring biomarker in GC." 6 Circ-ELF2 Acts as a Competing Endogenous RNA to Facilitate Glioma Cell Proliferation and Aggressiveness by Targeting MiR-510-5p/MUC15 Signaling. - hsa_circ_ELF2 - DOID:0060108 brain glioma glioma "RT-qPCR, microarray" up-regulated This study indicates that circ-ELF2/miR-510-5p/MUC15 signaling plays a key role in promoting the occurrence and development of GM. 1 The Novel Circular RNA Circ-PGAP3 Promotes the Proliferation and Invasion of Triple Negative Breast Cancer by Regulating the miR-330-3p/Myc Axis. - hsa_circ_PGAP3 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated The Novel Circular RNA Circ-PGAP3 Promotes the Proliferation and Invasion of Triple Negative Breast Cancer by Regulating the miR-330-3p/Myc Axis. 1 Hsa_circ_0003645 Promotes Breast Cancer Progression by Regulating miR-139-3p/HMGB1 Axis. hsa_circ_0003645 hsa_circ_C16orf62 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_0003645 functions as a ceRNA for miR-139-3p, which could upregulate HMGB1 and further promote cell proliferation in breast cancer." 1 "Knockdown of CircCRIM1 Inhibits HDAC4 to Impede Osteosarcoma Proliferation, Migration, and Invasion and Facilitate Autophagy by Targeting miR-432-5p." - hsa_circ_CRIM1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Knockdown of CircCRIM1 Inhibits HDAC4 to Impede Osteosarcoma Proliferation, Migration, and Invasion and Facilitate Autophagy by Targeting miR-432-5p." 2 CircRNA circUGGT2 Contributes to Hepatocellular Carcinoma Development via Regulation of the miR-526b-5p/RAB1A Axis. - hsa_circ_UGGT2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircUGGT2 silencing inhibited HCC development via modulating the miR-526b-5p/RAB1A axis, providing a possible target for HCC treatment." 2 Circular RNA circCSNK1G3 induces HOXA10 signaling and promotes the growth and metastasis of lung adenocarcinoma cells through hsa-miR-143-3p sponging. - hsa_circ_CSNK1G3 - DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" up-regulated Circular RNA circCSNK1G3 induces HOXA10 signaling and promotes the growth and metastasis of lung adenocarcinoma cells through hsa-miR-143-3p sponging. 1 Androgen receptor suppresses vasculogenic mimicry in hepatocellular carcinoma via circRNA7/miRNA7-5p/VE-cadherin/Notch4 signalling. - hsa_circ_RNA7 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "AR could suppress the formation of HCC VM by down-regulating circRNA7/miRNA7-5p/VE-Cadherin/Notch4 signals in HCC, which will help in the design of novel therapies against HCC." 1 circSETD3 regulates MAPRE1 through miR-615-5p and miR-1538 sponges to promote migration and invasion in nasopharyngeal carcinoma. - hsa_circ_SETD3 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, RNA-seq" up-regulated circSETD3 regulates MAPRE1 through miR-615-5p and miR-1538 sponges to promote migration and invasion in nasopharyngeal carcinoma. 2 Overexpression of hsa_circ_0001715 is a Potential Diagnostic and Prognostic Biomarker in Lung Adenocarcinoma. hsa_circ_0001715 hsa_circ_LIMK1 - DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" up-regulated "Our study revealed an aberrant circRNA expression profile in lung adenocarcinoma, and hsa_circ_0001715 is up-regulated and could act as a novel diagnostic and prognostic biomarker for lung adenocarcinoma." 1 Circ_0000260 Regulates the Development and Deterioration of Gastric Adenocarcinoma with Cisplatin Resistance by Upregulating MMP11 via Targeting MiR-129-5p. hsa_circ_0000260 hsa_circ_SMC3 - DOID:3717 gastric adenocarcinoma gastric adenocarcinoma RT-qPCR up-regulated Circ_0000260 regulated CDDP chemoresistance of GAC by promoting MMP11 expression via targeting miR-129-5p. 1 Identification of hsa_circ_0039053 as an up-regulated and oncogenic circRNA in hepatocellular carcinoma via the miR-637-mediated USP21 activation. hsa_circ_0039053 hsa_circ_ITGAL - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "hsa_circ_0039053 could be regarded as a competing endogenous RNA (ceRNA) to positively modulate the expression of USP21 combining with miR-637, which provided a potential target in HCC treatment." 1 Exosomes Derived From CircAkap7-Modified Adipose-Derived Mesenchymal Stem Cells Protect Against Cerebral Ischemic Injury. - hsa_circ_Akap7 - DOID:6713 cerebrovascular disease ischemic stroke RT-qPCR up-regulated We demonstrate here that exo-circAkap7 protected against cerebral ischemic injury by promoting autophagy and ameliorating oxidative stress. 1 Circular RNA circ_0032821 contributes to oxaliplatin (OXA) resistance of gastric cancer cells by regulating SOX9 via miR-515-5p. hsa_circ_0032821 hsa_circ_CEP128 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Exosomal circ_0032821 boosted OXA resistance of GC cells partly by the miR-515-5p/SOX9 axis, hinting a promising therapeutic target for GC treatment." 3 Circular RNA circCCDC9 alleviates ischaemic stroke ischaemia/reperfusion injury via the Notch pathway. - mmu_circ_CCDC9 - DOID:6713 cerebrovascular disease ischemic stroke RT-qPCR up-regulated "overexpression of circCCDC9 protected the blood-brain barrier and inhibited apoptosis by suppressing the Notch1 signalling pathway, while knockdown of circCCDC9 had the opposite effects. Our findings showed that circCCDC9 is a potential novel therapeutic target for cerebrovascular protection in acute ischaemic stroke." 1 Sevoflurane suppresses cell viability and invasion and promotes cell apoptosis in colon cancer by modulating exosome_mediated circ_HMGCS1 via the miR_34a_5p/SGPP1 axis. hsa_circ_0072391 hsa_circ_HMGCS1 - DOID:219 colon cancer colon cancer RT-qPCR down-regulated Sevoflurane suppresses cell viability and invasion and promotes cell apoptosis in colon cancer by modulating exosome_mediated circ_HMGCS1 via the miR_34a_5p/SGPP1 axis. 1 Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18. - hsa_circ_PDE4D - DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "Mechanistically, we found that circPDE4D exerted its effect by acting as a sponge for miR-103a-3p and thereby regulated FGF18 expression, which is a direct target of miR-103a-3p. In conclusion, our findings highlight a novel protective role of circPDE4D in OA pathogenesis and indicate that the targeting of the circPDE4D-miR-103a-3p-FGF18 axis might provide a potential and promising approach for OA therapy." 2 Circ-PTK2 promotes the proliferation and suppressed the apoptosis of acute myeloid leukemia cells through targeting miR-330-5p/FOXM1 axis. - hsa_circ_PTK2 - DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated Circ-PTK2 promotes the proliferation and suppressed the apoptosis of acute myeloid leukemia cells through targeting miR-330-5p/FOXM1 axis. 2 Bupivacaine suppresses the progression of gastric cancer through regulating circ_0000376/miR-145-5p axis. hsa_circ_0000376 hsa_circ_PRH1-PRR4 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Bupivacaine exerted an anti-tumor role to suppress the progression of gastric cancer through reducing the abundance of circ_0000376 and up-regulating miR-145-5p. 1 Circ0106714 inhibits tumorigenesis of colorectal cancer by sponging miR-942-5p and releasing DLG2 via Hippo-YAP signaling. hsa_circ_0106714 hsa_circ_TADA2A - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "circ0106714 could suppress CRC by sponging miR-942-5p and releasing DLG2, thus promoting YAP phosphorylation." 3 Circular RNA circ_0000043 promotes endometrial carcinoma progression by regulating miR-1271-5p/CTNND1 axis. hsa_circ_0000043 hsa_circ_PUM1 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "circ_0000043 positively regulated CTNND1 expression by sponging miR-1271-5p. CONCLUSION: Circ_0000043 knockdown inhibited the progression of EC by regulating miR-1271-5p/CTNND1 axis, which might provide a promising circRNA-targeted therapy for EC." 2 Circular RNA profiling identifies circ102049 as a key regulator of colorectal liver metastasis. - - circ102049 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "Our findings provide new evidence that circ102049 might be a potential prognostic factor in CRC, and the circ102049-miR-761/miR-192-3p-FRAS1 axis as an anti-metastatic target for CRC patients." 1 Depletion of circ_0007841 inhibits multiple myeloma development and BTZ resistance via miR-129-5p/JAG1 axis. hsa_circ_0007841 - circ_0007841 DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated "Circ_0007841 positively regulated JAG1 expression via absorbing miR-129-5p. Circ_0007841 knockdown inhibited MM cell proliferation, metastasis and chemoresistance through modulating miR-129-5p/JAG1 axis, suggesting that circ_0007841 might serve as a potential therapeutic target of MM.. Circ_0007841 knockdown inhibited MM cell proliferation, metastasis and chemoresistance through modulating miR-129-5p/JAG1 axis, suggesting that circ_0007841 might serve as a potential therapeutic target of MM." 5 Hsa_circ_0060450 Negatively Regulates Type I Interferon-Induced Inflammation by Serving as miR-199a-5p Sponge in Type 1 Diabetes Mellitus. hsa_circ_0060450 hsa_circ_MYBL2 - DOID:9744 type 1 diabetes mellitus type 1 diabetes mellitus "RT-qPCR, microarray" up-regulated Hsa_circ_0060450 Negatively Regulates Type I Interferon-Induced Inflammation by Serving as miR-199a-5p Sponge in Type 1 Diabetes Mellitus. 1 Circular RNA Expression Profiling Identifies Glaucoma-Related Circular RNAs in Various Chronic Ocular Hypertension Rat Models. hsa_circ_0023826 hsa_circ_ODZ4 - DOID:1686 glaucoma glaucoma RT-qPCR down-regulated "Together with the target microRNAs underlying the top differentially expressed circular RNAs, a new target of hsa_circ_0023826 and its host gene TENM4 were identified and further verified in the aqueous humor of glaucoma patients, indicating a promising biomarker for the disease." 2 Circular RNA Expression Profiling Identifies Glaucoma-Related Circular RNAs in Various Chronic Ocular Hypertension Rat Models. hsa_circ_0023826 rno_circ_ODZ4 - DOID:1686 glaucoma glaucoma RT-qPCR down-regulated "Together with the target microRNAs underlying the top differentially expressed circular RNAs, a new target of hsa_circ_0023826 and its host gene TENM4 were identified and further verified in the aqueous humor of glaucoma patients, indicating a promising biomarker for the disease." 1 CircRNA_0092516 regulates chondrocyte proliferation and apoptosis in osteoarthritis through the miR-337-3p/PTEN axis. hsa_circ_0092516 - - DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "our data expounded that the interference with circRNA_0092516 boosted chondrocyte proliferation and restrained cell apoptosis through the miR-337-3p/PTEN axis, eventually slowed down the progress of OA." 1 Circular RNA circTP63 enhances estrogen receptor-positive breast cancer progression and malignant behaviors through the miR-873-3p/FOXM1 axis. - hsa_circ_TP63 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circTP63 binds to miR-873-3p and prevents the targeting of FOXM1, thus inducing the progression and malignant behaviors of estrogen receptor-positive breast cancer, such as cell proliferation, cell cycle dysregulation, invasion, migration and even tumor growth. CircTP63 might be a potential biomarker or target to treat estrogen receptor-positive breast cancer patients in the future." 1 Circular RNA hsa_circ_0007364 increases cervical cancer progression through activating methionine adenosyltransferase II alpha (MAT2A) expression by restraining microRNA-101-5p. hsa_circ_0007364 hsa_circ_PTP4A2 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "hsa_circ_0007364 might serve as an oncogenic circRNA in CC progression by regulating the miR-101-5p/MAT2A axis, which provides a potential therapeutic target to the treatment. Research highlights hsa_circ_0007364 was upregulated in CC hsa_circ_0007364 promoted CC cell progression hsa_circ_0007364/miR-101-5p/MAT2A axis in CC." 1 Circular RNA SIPA1L1 regulates osteoblastic differentiation of stem cells from apical papilla via miR-204-5p/ALPL pathway. - hsa_circ_SIPA1L1 circRNA-SIPA1L1 DOID:12347 osteogenesis imperfecta osteogenesis RT-qPCR up-regulated CircSIPA1L1 upregulates ALPL through targeting miR-204-5p and promotes the osteogenic differentiation of SCAPs. 2 Downregulating circRNA_0044516 Inhibits Cell Proliferation in Gastric Cancer Through miR-149/Wnt1/beta-catenin Pathway. hsa_circ_0044516 hsa_circ_COL1A1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Mechanistically, silencing circRNA_0044516 reduced the protein level of Wnt1 and beta-catenin through miR-149, and finally suppressed viability and contributed to apoptosis of GC cells. Moreover, circRNA_0044516 knockdown inhibited the tumor growth of HGC-27 cells in nude mice. CONCLUSIONS: Our results indicated an important role of circRNA_0044516 in GC and elucidated that downregulation of circRNA_0044516 inhibits the proliferation of GC cells through miR-149/Wnt1/beta-catenin." 3 Circular RNA hsa_circ_0001445 in plasma as a novel biomarker for osteoporosis in postmenopausal women. hsa_circ_0001445 hsa_circ_SMARCA5 - DOID:11476 osteoporosis osteoporosis RT-qPCR down-regulated "The expression levels of hsa_circ_0001445 in plasma were much lower in OPO patients compared with OPE patients and healthy controls. Its expression was positively correlated with the T-score and was negatively correlated with beta-isomerized C-terminal telopeptides (beta-CTx). It could distinguish OPE or/and OPO patients from healthy controls. Moreover, its expression was significantly upregulated in the plasma of OPO patients after anti-osteoporotic treatment. " 1 Exosomal transfer of circular RNA FBXW7 ameliorates the chemoresistance to oxaliplatin in colorectal cancer by sponging miR-18b-5p. - hsa_circ_FBXW7 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "The circ-FBXW7 delivery by exosomes could ameliorate chemoresistance to oxaliplatin in CRC by directly binding to miR-128-3p, suggesting a promising therapeutic strategy for oxaliplatin-resistant CRC patients." 3 Downregulation of circular RNA HECTD1 induces neuroprotection against ischemic stroke through the microRNA-133b/TRAF3 pathway. - hsa_circ_HECTD1 - DOID:6713 cerebrovascular disease ischemic stroke RT-qPCR down-regulated "circ-HECTD1 knockdown inhibited the expression of TRAF3 by targeting miR-133b, thereby attenuating neuronal injury caused by cerebral ischemia." 3 Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression. hsa_circ_0032462 - circ_0032462 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "our research revealed the function of circ_0032462 in osteosarcoma progression, which might serve as a novel chemotherapeutic target for osteosarcoma." 2 circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2. - hsa_circ_CUL2 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "circCUL2 may function as a tumor suppressor and regulator of cisplatin sensitivity through miR-142-3p/ROCK2-mediated autophagy activation, which could be a key mechanism and therapeutic target for GC." 1 Hsa_circ_0043278 functions as competitive endogenous RNA to enhance glioblastoma multiforme progression by sponging miR-638. hsa_circ_0043278 hsa_circ_TADA2A - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated circ-0043278/miRNA-638/ Homeobox A9 (HOXA9) axis had a vital function in promoting GBM progression. Our findings may provide potential new targets for the diagnosis and therapy of GBM. 1 Circular RNA TMEM87A promotes cell proliferation and metastasis of gastric cancer by elevating ULK1 via sponging miR-142-5p. - hsa_circ_TMEM87A - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circTMEM87A functions as an oncogene through the miR-142-5p/ULK1 axis in GC. CircTMEM87A might be a prognostic biomarker as well as a promising therapeutic target for GC. 1 Circular RNA circ-PRKCI promotes lung cancer progression by binding to microRNA-1324 to regulate MECP2 expression. - hsa_circ_PRKCI - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Our study shows for the first time that circ-PRKCI modulates the progression of LCa through microRNA-150-5p/MECP2 axis. 3 CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1. - hsa_circ_GLCE - DOID:90 degenerative disc disease intervertebral disc degeneration "RT-qPCR, microarray" down-regulated CircGLCE attenuates IDD by inhibiting the apoptosis of NP cells and ECM degradation through the targeting of miR-587/STAP1. CircGLCE may be a potential therapeutic target for IDD treatments. 1 circ-CBFB upregulates p66Shc to perturb mitochondrial dynamics in APAP-induced liver injury. - hsa_circ_CBFB - DOID:409 liver disease liver injury RT-qPCR up-regulated "p66Shc is a key regulator of APAP-induced liver injury that acts by triggering mitochondrial dynamics perturbation. circ-CBFB functions as a ceRNA to regulate p66Shc during APAP-induced liver injury, which may provide a potential therapeutic target." 1 Soy isoflavone genistein inhibits hsa_circ_0031250/miR-873-5p/FOXM1 axis to suppress non-small-cell lung cancer progression. hsa_circ_0031250 hsa_circ_PRMT5 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated Soy isoflavone genistein inhibits hsa_circ_0031250/miR-873-5p/FOXM1 axis to suppress non-small-cell lung cancer progression. 3 Circular RNA TGFBR2 acts as a ceRNA to suppress nasopharyngeal carcinoma progression by sponging miR-107. - hsa_circ_TGFBR2 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, microarray" down-regulated circTGFBR2 may serve as a novel tumor suppressive factor and potential target for new therapies in NPC patients. 1 Hsa-circ_0010283 Regulates Oxidized Low-Density Lipoprotein-Induced Proliferation and Migration of Vascular Smooth Muscle Cells by Targeting the miR-133a-3p/Pregnancy-Associated Plasma Protein A Axis. hsa_circ_0010283 hsa_circ_UBR4 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "circ_0010283 participated in ox-LDL-induced dysfunctions of HVSMCs by modulating the miR-133a-3p/PAPPA pathway, suggesting that circ_0010283 might be associated with atherosclerosis pathogenesis." 3 Circular RNA MGAT1 regulates cell proliferation and apoptosis in hypoxia-induced cardiomyocytes through miR-34a/YAP1 axis. hsa_circ_0075370 hsa_circ_MGAT1 - DOID:1682 congenital heart disease congenital heart disease RT-qPCR down-regulated "circMGAT1 sponged miR-34a to regulate the expression of YAP1. In conclusion, circMGAT1 inhibited cell apoptosis and enhanced cell proliferation by regulating the miR-34a/YAP1 axis, providing a therapy target for the treatment of human CHD." 1 Circ_0067835 sponges miR-324-5p to induce HMGA1 expression in endometrial carcinoma cells. hsa_circ_0067835 hsa_circ_IFT80 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "circ_0067835 can compete with miR-324-5p, resulting in HMGA1 up-regulation, and therefore induce the development of endometrial cancer." 2 Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit. hsa_circ_0004872 hsa_circ_MAPK1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "hsa_circ_0004872 acted as a tumor suppressor in GC by forming a negative regulatory loop consisting of hsa_circ_0004872/miR-224/Smad4/ADAR1. Thus, hsa_circ_0004872 may serve as a potential biomarker and therapeutic target for GC." 2 Upregulated circPDK1 Promotes RCC Cell Migration and Invasion by Regulating the miR-377-3P-NOTCH1 Axis in Renal Cell Carcinoma. - hsa_circ_PDK1 - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated "CircPDK1 is aberrantly expressed in RCC and promotes the metastasis of RCC cells mainly through sponging miR-377-3P and reducing its negative regulation of NOTCH1. Thus, circPDK1 may act as a therapeutic target and biomarker for RCC." 1 Circ_0109046 Promotes the Progression of Endometrial Cancer via Regulating miR-136/HMGA2 Axis. hsa_circ_0109046 hsa_circ_ZNF700 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "Circ_0109046 accelerated EC progression via modulating miR-136/HMGA2 axis, indicating that circ_0109046 might be a promising therapeutic target for EC." 2 "Ropivacaine Inhibits Cell Proliferation, Migration and Invasion, Whereas Induces Oxidative Stress and Cell Apoptosis by circSCAF11/miR-145-5p Axis in Glioma." - hsa_circ_SCAF11 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Ropivacaine suppressed glioma progression by regulating circSCAF11 and miR-145-5p, which might provide a theoretical foundation in glioma treatment." 2 Exosomal circular RNA_400068 promotes the development of renal cell carcinoma via the miR_210_5p/SOCS1 axis. - - hsa_circ_400068 DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated "the present findings provided a novel insight into the crucial regulatory functions of circ_400068 in RCC, and the circ_400068/miR_210_5p/SOCS1 axis could be a candidate therapeutic target for the treatment of patients with RCC." 1 Circular RNA circSEMA5A promotes bladder cancer progression by upregulating ENO1 and SEMA5A expression. hsa_circ_0071820 hsa_circ_SEMA5A - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated circSEMA5A is upregulated in BC and facilitates BC progression by mediating miR-330-5p/ENO1 signaling and upregulating SEMA5A expression. 1 Circular RNA HIPK3 plays a carcinogenic role in cervical cancer progression via regulating miR-485-3p/FGF2 axis. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Overexpressed circHIPK3 could remarkably expedite the proliferation, migration and invasion of SiHa cells, and knocking down circHIPK3 could significantly impede the proliferation, migration and invasion of HeLa cells. MiR-485-3p can directly bind to circHIPK3 and the 3UTR of FGF2. Overexpression of circHIPK3 triggered the upregulation of FGF2 expression while knockdown of circHIPK3 reduced FGF2 expression in CC cells, and the transfection of miR-485-3p mimics reversed the upregulation of FGF2 expression and enhanced malignant phenotypes in CC cells with overexpressed circHIPK3." 4 "Depletion of circ-BIRC6, a circular RNA, suppresses non-small cell lung cancer progression by targeting miR-4491." - hsa_circ_BIRC6 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ-BIRC6 functions as a critical regulator of proliferation and apoptosis via binding to and negatively regulating miR-4491, suggesting that circ-BIRC6 might be a potential target for treatment of NSCLC." 5 "Circ_0057553/miR-515-5p Regulates Prostate Cancer Cell Proliferation, Apoptosis, Migration, Invasion and Aerobic Glycolysis by Targeting YES1." hsa_circ_0057553 - circ_0057553 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Circ_0057553 affected PCa cell viability, migration, invasion, apoptosis and glycolysis through miR-515-5p/YES1 axis." 1 Hsa_circ_0006916 Knockdown Represses the Development of Hepatocellular Carcinoma via Modulating miR-599/SRSF2 Axis. hsa_circ_0006916 hsa_circ_HOMER1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ_0006916 knockdown represses the progression of HCC via regulating miR-599 and SRSF2. 2 Down-Regulation of Circ_0032833 Sensitizes Colorectal Cancer to 5-Fluorouracil and Oxaliplatin Partly Depending on the Regulation of miR-125-5p and MSI1. hsa_circ_0032833 - circ_0032833 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "This study illuminated an unambiguous mechanism circ_0032833/miR-125-5p/MSI1 on regulating 5-fluorouracil and oxaliplatin sensitivities in FOLFOX therapy, maybe providing a deep insight of resistance formation and developing a novel strategy to enhance chemosensitivity in CRC." 1 "A novel circular RNA, hsa_circ_0030998 suppresses lung cancer tumorigenesis and Taxol resistance by sponging miR-558." hsa_circ_0030998 hsa_circ_LAMP1 - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "hsa_circ_0030998 can slow down the progression of lung cancer by targeting miR-558 and suppress malignant phenotypes such as proliferation, migration, and invasion progression of lung cancer cells. Therefore, we highlight that circ_0030998 could be a novel tumor suppressor of lung cancer." 1 Effect of the Up-Regulation of Circular RNA Hsa_circ_0069767 Derived from C-KIT on the Biological Behavior of Multiple Myeloma Cells. hsa_circ_0069767 hsa_circ_KIT - DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated "Patients with high expression of circ_0069767 had longer PFS and OS. Cell function experiments showed that overexpression of circ_0069767 in MM cells led to decreased proliferation, migration and invasion, but increased apoptosis; meanwhile, knockdown of circ_0069767 caused opposite biological behaviors. Circ_0069767 by sponging miR-636 in MM cells regulates the expression of K-RAS while the K-RAS gene remained unmutated." 1 Hypoxia-induced circular RNA hsa_circ_0008450 accelerates hepatocellular cancer progression via the miR-431/AKAP1 axis. hsa_circ_0008450 hsa_circ_CMTM3 - DOID:684 hepatocellular carcinoma hepatocellular cancer RT-qPCR up-regulated "circ_0008450 repression mitigated the progression of HCC under hypoxia by downregulating AKAP1 via miR-431, providing a potential target for HCC treatment." 3 Circular RNA microarray expression profile and potential function of circ0005875 in clear cell renal cell carcinoma. hsa_circ_0005875 hsa_circ_NPHP3-ACAD11 - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, microarray" up-regulated These data indicate that hsa_circ_0005875 might play a role in promoting tumor growth and metastasis and be a potential biomarker of ccRCC. 1 Circular RNA circRPPH1 promotes triple-negative breast cancer progression via the miR-556-5p/YAP1 axis. - hsa_circ_RPPH1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Our data reveal that circRPPH1 plays a vital regulatory role in breast cancer via the miR-556-5p/YAP1 axis and may serve as a promising therapeutic target for breast cancer treatment. 9 "Hsa_circ_0088233 Alleviates Proliferation, Migration, and Invasion of Prostate Cancer by Targeting hsa-miR-185-3p." hsa_circ_0088233 hsa_circ_PAPPA - DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" up-regulated circ_0088233 may function as an oncogene and play an oncogenic role by sponging hsa-miR-185-3p. This study increases the understanding of circRNAs in the progression of prostate cancer. These results implicate circ_0088233 as a potential therapeutic target for prostate cancer. 1 CircCOG8 Downregulation Contributes to the Compression-Induced Intervertebral Disk Degeneration by Targeting miR-182-5p and FOXO3. - hsa_circ_COG8 - DOID:90 degenerative disc disease intervertebral disk degeneration RT-qPCR down-regulated the present study revealed that the circCOG8/miR-182-5p/FOXO3 pathway was an important underlying mechanism in the involvement of compression during the IDD progression. Intervention of circCOG8 is a new therapeutic strategy for IDD treatment. 1 Promotion of Bronchopulmonary Dysplasia Progression Using Circular RNA circabcc4 via Facilitating PLA2G6 Expression by Sequestering miR-663a. - hsa_circ_ABCC4 - DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia RT-qPCR up-regulated "circABCC4 promotes the evolving of BPD by spongening miR-663a and up-regulating PLA2G6 expression, which makes circABCC4 an ideal molecular target for early diagnosis and intervention of BPD." 1 "Circular RNA circ-CCAC1 Facilitates Adrenocortical Carcinoma Cell Proliferation, Migration, and Invasion through Regulating the miR-514a-5p/C22orf46 Axis." - hsa_circ_CCAC1 - DOID:3948 adrenocortical carcinoma adrenocortical carcinoma RT-qPCR up-regulated "Circular RNA circ-CCAC1 Facilitates Adrenocortical Carcinoma Cell Proliferation, Migration, and Invasion through Regulating the miR-514a-5p/C22orf46 Axis." 1 Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression. - hsa_circ_MCTP2 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated CircMCTP2 sensitizes GC to CDDP through the upregulation of MTMR3 by sponging miR-99a-5p. Overexpression of CircMCTP2 could be a new therapeutic strategy for counteracting CDDP resistance in GC. 1 Involvement of circRNA_0007059 in the regulation of postmenopausal osteoporosis by promoting the microRNA-378/BMP-2 axis. hsa_circ_0007059 - circ_0007059 DOID:11476 osteoporosis postmenopausal osteoporosis RNA-seq down-regulated circ_0007059 plays an important role in osteoclastogenesis via the miR-378/BMP-2 signaling pathway. 1 Involvement of circRNA_0007059 in the regulation of postmenopausal osteoporosis by promoting the microRNA-378/BMP-2 axis. hsa_circ_0001795 - circ_0001795 DOID:11476 osteoporosis postmenopausal osteoporosis RNA-seq down-regulated "We selected the top six circRNAs with different expression levels, including three circRNAs that were upregulated (circ_0043813, circ_0001649, and circ_0005654) and three that were downregulated (circ_0007059, circ_0001204, and circ_0001795), for quantitative real-time PCR (qPCR) validation." 2 Involvement of circRNA_0007059 in the regulation of postmenopausal osteoporosis by promoting the microRNA-378/BMP-2 axis. hsa_circ_0001204 - circ_0001204 DOID:11476 osteoporosis postmenopausal osteoporosis RNA-seq down-regulated "We selected the top six circRNAs with different expression levels, including three circRNAs that were upregulated (circ_0043813, circ_0001649, and circ_0005654) and three that were downregulated (circ_0007059, circ_0001204, and circ_0001796), for quantitative real-time PCR (qPCR) validation." 1 Involvement of circRNA_0007059 in the regulation of postmenopausal osteoporosis by promoting the microRNA-378/BMP-2 axis. hsa_circ_0043813 - circ_0043813 DOID:11476 osteoporosis postmenopausal osteoporosis RNA-seq up-regulated "We selected the top six circRNAs with different expression levels, including three circRNAs that were upregulated (circ_0043813, circ_0001649, and circ_0005654) and three that were downregulated (circ_0007059, circ_0001204, and circ_0001797), for quantitative real-time PCR (qPCR) validation." 1 Involvement of circRNA_0007059 in the regulation of postmenopausal osteoporosis by promoting the microRNA-378/BMP-2 axis. hsa_circ_0001649 - circ_0001649 DOID:11476 osteoporosis postmenopausal osteoporosis RNA-seq up-regulated "We selected the top six circRNAs with different expression levels, including three circRNAs that were upregulated (circ_0043813, circ_0001649, and circ_0005654) and three that were downregulated (circ_0007059, circ_0001204, and circ_0001798), for quantitative real-time PCR (qPCR) validation." 1 Involvement of circRNA_0007059 in the regulation of postmenopausal osteoporosis by promoting the microRNA-378/BMP-2 axis. hsa_circ_0005654 - circ_0005654 DOID:11476 osteoporosis postmenopausal osteoporosis RNA-seq up-regulated "We selected the top six circRNAs with different expression levels, including three circRNAs that were upregulated (circ_0043813, circ_0001649, and circ_0005654) and three that were downregulated (circ_0007059, circ_0001204, and circ_0001799), for quantitative real-time PCR (qPCR) validation." 1 Circular RNA Paired-Related Homeobox 1 Promotes Gastric Carcinoma Cell Progression via Regulating MicroRNA-665/YWHAZ Axis. hsa_circ_0004370 hsa_circ_PRRX1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Circ-PRRX1 knockdown suppressed GC development by targeting miR-665 to inhibit YWHAZ expression, and the potential molecular mechanism may provide a theoretical basis for GC therapy." 2 Differentially expressed circular RNAs and the competing endogenous RNA network associated with preeclampsia. - - circRNA15922 DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "Six of the downregulated circRNAs (circRNA15922, circRNA4675, circRNA17433, circRNA8840, circRNA10271, and circRNA2713) were observed to be significantly downregulated in the PE samples, which was in keeping with the sequencing results." 1 Differentially expressed circular RNAs and the competing endogenous RNA network associated with preeclampsia. - - circRNA4675 DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "Six of the downregulated circRNAs (circRNA15922, circRNA4675, circRNA17433, circRNA8840, circRNA10271, and circRNA2713) were observed to be significantly downregulated in the PE samples, which was in keeping with the sequencing results." 1 Differentially expressed circular RNAs and the competing endogenous RNA network associated with preeclampsia. - - circRNA17433 DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "Six of the downregulated circRNAs (circRNA15922, circRNA4675, circRNA17433, circRNA8840, circRNA10271, and circRNA2713) were observed to be significantly downregulated in the PE samples, which was in keeping with the sequencing results." 1 Differentially expressed circular RNAs and the competing endogenous RNA network associated with preeclampsia. - - circRNA8840 DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "Six of the downregulated circRNAs (circRNA15922, circRNA4675, circRNA17433, circRNA8840, circRNA10271, and circRNA2713) were observed to be significantly downregulated in the PE samples, which was in keeping with the sequencing results." 1 Differentially expressed circular RNAs and the competing endogenous RNA network associated with preeclampsia. - - circRNA10271 DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "Six of the downregulated circRNAs (circRNA15922, circRNA4675, circRNA17433, circRNA8840, circRNA10271, and circRNA2713) were observed to be significantly downregulated in the PE samples, which was in keeping with the sequencing results." 1 Differentially expressed circular RNAs and the competing endogenous RNA network associated with preeclampsia. - - circRNA2713 DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "Six of the downregulated circRNAs (circRNA15922, circRNA4675, circRNA17433, circRNA8840, circRNA10271, and circRNA2713) were observed to be significantly downregulated in the PE samples, which was in keeping with the sequencing results." 1 Circ_PSD3 promotes the progression of papillary thyroid carcinoma via the miR-637/HEMGN axis. - hsa_circ_PSD3 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated Circ_PSD3 promoted the progression of PTC through regulating miR-637/HEMGN axis and activating PI3K/Akt signaling. Circ_PSD3/miR-637/HEMGN signaling axis might be a potential target for PTC therapy. 5 CircSEC31A Promotes the Malignant Progression of Non-Small Cell Lung Cancer Through Regulating SEC31A Expression via Sponging miR-376a. - hsa_circ_SEC31A - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our findings first identified that the knockdown of circSEC31A suppressed NSCLC malignant progression at least partly through modulating SEC31A expression by acting as a miR-376a sponge, providing a novel molecular target of NSCLC therapy." 1 Circular RNA circANKRD36 regulates Casz1 by targeting miR-599 to prevent osteoarthritis chondrocyte apoptosis and inflammation. - hsa_circ_ANKRD36 - DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated circANKRD36 sponge miR-599 to up-regulate the expression of Casz1 and thus prevent apoptosis and inflammation in OA. 1 Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation. - hsa_circ_MAP3K5 - DOID:178 vascular disease neointimal hyperplasia RNA-seq up-regulated "We identify circMAP3K5 as a master regulator of TET2-mediated vascular SMC differentiation. Targeting the circMAP3K5/miR-22-3p/TET2 axis may provide a potential therapeutic strategy for diseases associated with intimal hyperplasia, including restenosis and atherosclerosis." 1 CircTBL1XR1/miR-424 axis regulates Smad7 to promote the proliferation and metastasis of colorectal cancer. - hsa_circ_TBL1XR1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circTBL1XR1 was highly expressed in colon cancer, and miR-424 was poorly expressed in colon cancer cells. circTBL1XR1 regulates the expression of Smad7 through miR-424, thereby affecting the malignant progression of colorectal cancer." 1 Circular RNA circ_0008305 aggravates hepatocellular carcinoma growth through binding to miR-186 and inducing TMED2. hsa_circ_0008305 - circ_0008305 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circ_0008305 up-regulated TMED2 expression by sponging miR-186, which resulted in significantly induced HCC progression in vitro and in vivo. These revealed the significant role of circ_0008305 in HCC progression, which might indicate a new perspective on circRNAs in HCC development." 1 "Circular RNA circGFRA1 promotes angiogenesis, cell proliferation and migration of hepatocellular carcinoma by combining with miR-149." - hsa_circ_GFRA1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircGFRA1 is highly expressed in HCC and its level is negatively correlated with miR-149 expression. CircGFRA1 can promote the proliferative, migration and angiogenic activity of HCC by binding miR-149." 2 Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis. hsa_circ_000121 - hsa_circRNA_000121 DOID:3969 thyroid gland papillary carcinoma papillary thyroid microcarcinoma "RT-qPCR, microarray" up-regulated "In total, 400 significantly upregulated and 290 significantly downregulated circRNAs were identified in PTMC (L) compared with PTMC. Among them, 10 circRNAs were selected and validated by real time-PCR. Putative microRNAs (miRNAs) that could bind to the differentially expressed circRNAs were predicted." 1 Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis. hsa_circ_000466 - hsa_circRNA_000466 DOID:3969 thyroid gland papillary carcinoma papillary thyroid microcarcinoma "RT-qPCR, microarray" up-regulated "In total, 400 significantly upregulated and 290 significantly downregulated circRNAs were identified in PTMC (L) compared with PTMC. Among them, 11 circRNAs were selected and validated by real time-PCR. Putative microRNAs (miRNAs) that could bind to the differentially expressed circRNAs were predicted." 1 Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis. hsa_circ_001059 - hsa_circRNA_001059 DOID:3969 thyroid gland papillary carcinoma papillary thyroid microcarcinoma "RT-qPCR, microarray" up-regulated "In total, 400 significantly upregulated and 290 significantly downregulated circRNAs were identified in PTMC (L) compared with PTMC. Among them, 12 circRNAs were selected and validated by real time-PCR. Putative microRNAs (miRNAs) that could bind to the differentially expressed circRNAs were predicted." 1 Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis. - - hsa_circRNA_051239 DOID:3969 thyroid gland papillary carcinoma papillary thyroid microcarcinoma "RT-qPCR, microarray" up-regulated "In total, 400 significantly upregulated and 290 significantly downregulated circRNAs were identified in PTMC (L) compared with PTMC. Among them, 13 circRNAs were selected and validated by real time-PCR. Putative microRNAs (miRNAs) that could bind to the differentially expressed circRNAs were predicted." 1 Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis. - - hsa_circRNA_102116 DOID:3969 thyroid gland papillary carcinoma papillary thyroid microcarcinoma "RT-qPCR, microarray" up-regulated "In total, 400 significantly upregulated and 290 significantly downregulated circRNAs were identified in PTMC (L) compared with PTMC. Among them, 14 circRNAs were selected and validated by real time-PCR. Putative microRNAs (miRNAs) that could bind to the differentially expressed circRNAs were predicted." 1 Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis. hsa_circ_001729 - hsa_circRNA_001729 DOID:3969 thyroid gland papillary carcinoma papillary thyroid microcarcinoma "RT-qPCR, microarray" down-regulated "In total, 400 significantly upregulated and 290 significantly downregulated circRNAs were identified in PTMC (L) compared with PTMC. Among them, 15 circRNAs were selected and validated by real time-PCR. Putative microRNAs (miRNAs) that could bind to the differentially expressed circRNAs were predicted." 1 Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis. hsa_circ_004183 - hsa_circRNA_004183 DOID:3969 thyroid gland papillary carcinoma papillary thyroid microcarcinoma "RT-qPCR, microarray" down-regulated "In total, 400 significantly upregulated and 290 significantly downregulated circRNAs were identified in PTMC (L) compared with PTMC. Among them, 16 circRNAs were selected and validated by real time-PCR. Putative microRNAs (miRNAs) that could bind to the differentially expressed circRNAs were predicted." 1 Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis. - - hsa_circRNA_102051 DOID:3969 thyroid gland papillary carcinoma papillary thyroid microcarcinoma "RT-qPCR, microarray" down-regulated "In total, 400 significantly upregulated and 290 significantly downregulated circRNAs were identified in PTMC (L) compared with PTMC. Among them, 17 circRNAs were selected and validated by real time-PCR. Putative microRNAs (miRNAs) that could bind to the differentially expressed circRNAs were predicted." 1 Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis. - - hsa_circRNA_404686 DOID:3969 thyroid gland papillary carcinoma papillary thyroid microcarcinoma "RT-qPCR, microarray" down-regulated "In total, 400 significantly upregulated and 290 significantly downregulated circRNAs were identified in PTMC (L) compared with PTMC. Among them, 18 circRNAs were selected and validated by real time-PCR. Putative microRNAs (miRNAs) that could bind to the differentially expressed circRNAs were predicted." 1 Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis. - - hsa_circRNA_405571 DOID:3969 thyroid gland papillary carcinoma papillary thyroid microcarcinoma "RT-qPCR, microarray" down-regulated "In total, 400 significantly upregulated and 290 significantly downregulated circRNAs were identified in PTMC (L) compared with PTMC. Among them, 19 circRNAs were selected and validated by real time-PCR. Putative microRNAs (miRNAs) that could bind to the differentially expressed circRNAs were predicted." 1 CircSAMD4A aggravates H/R-induced cardiomyocyte apoptosis and inflammatory response by sponging miR-138-5p. - mmu_circ_SAMD4A - DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR up-regulated CircSAMD4A aggravates H/R-induced cardiomyocyte apoptosis and inflammatory response by sponging miR-138-5p. 1 Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma. hsa_circ_0000673 hsa_circ_RSL1D1 - DOID:4947 cholangiocarcinoma cholangiocarcinoma "RT-qPCR, microarray" up-regulated "Five DE circRNAs were validated with qRT-PCR in 40 pairs of dCCA tissues, and hsa_circ_0000673 showed promising diagnostic performance in distinguishing dCCA from normal tissues (AUC = 0.85, p < 0.01).inhibition of hsa_circ_0000673 suppressed the proliferation, migration, and invasion of CCA cells." 1 Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma. hsa_circ_0060144 hsa_circ_PHF20 - DOID:4947 cholangiocarcinoma cholangiocarcinoma "RT-qPCR, microarray" up-regulated "Five DE circRNAs were validated with qRT-PCR in 40 pairs of dCCA tissues, and hsa_circ_0000673 showed promising diagnostic performance in distinguishing dCCA from normal tissues (AUC = 0.85, p < 0.02)." 1 Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma. hsa_circ_0008274 hsa_circ_UGGT2 - DOID:4947 cholangiocarcinoma cholangiocarcinoma "RT-qPCR, microarray" up-regulated "Five DE circRNAs were validated with qRT-PCR in 40 pairs of dCCA tissues, and hsa_circ_0000673 showed promising diagnostic performance in distinguishing dCCA from normal tissues (AUC = 0.85, p < 0.03)." 1 Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma. hsa_circ_0139402 hsa_circ_PTCH1 - DOID:4947 cholangiocarcinoma cholangiocarcinoma "RT-qPCR, microarray" down-regulated "Five DE circRNAs were validated with qRT-PCR in 40 pairs of dCCA tissues, and hsa_circ_0000673 showed promising diagnostic performance in distinguishing dCCA from normal tissues (AUC = 0.85, p < 0.04)." 1 Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma. hsa_circ_0001714 hsa_circ_BAZ1B - DOID:4947 cholangiocarcinoma cholangiocarcinoma "RT-qPCR, microarray" down-regulated "Five DE circRNAs were validated with qRT-PCR in 40 pairs of dCCA tissues, and hsa_circ_0000673 showed promising diagnostic performance in distinguishing dCCA from normal tissues (AUC = 0.85, p < 0.05)." 1 N(6)-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating beta-catenin signaling. - hsa_circ_SORE circRNA-SORE DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circRNA-SORE sequestered miR-103a-2-5p and miR-660-3p by acting as a microRNA sponge, thereby competitively activating the Wnt/beta-catenin pathway and inducing sorafenib resistance." 2 A novel circular RNA circ-LRIG3 facilitates the malignant progression of hepatocellular carcinoma by modulating the EZH2/STAT3 signaling. - hsa_circ_LRIG3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated A novel circular RNA circ-LRIG3 facilitates the malignant progression of hepatocellular carcinoma by modulating the EZH2/STAT3 signaling. 3 CircPVT1 Promoted the Progression of Breast Cancer by Regulating MiR-29a-3p-Mediated AGR2-HIF-1alpha Pathway. - hsa_circ_PVT1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "CircPVT1 acts as an oncogene in BC via promoting the growth, invasion, migration and inhibiting apoptosis through miR-29a-3p-mediated AGR2-HIF-1alpha axis." 4 The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1alpha translation. - hsa_circ_ERBIN - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Our findings uncover a key mechanism for circ-Erbin mediated HIF-1alpha activation by miR-125a-5p-5p/miR-138-5p/4EBP-1 axis and circ-ERBIN is a potential target for CRC treatment. 1 Analyses of circRNA and mRNA profiles in the submandibular gland in hypertension. - - rno_circRNA_002139 DOID:10763 hypertension hypertension "RT-qPCR, microarray" down-regulated "The circRNA validation results as follows: rno_circRNA_002139, rno_circRNA_002996, rno_circRNA_002997, rno_circRNA_007850, rno_circRNA_009194, rno_circRNA_009195, rno_circRNA_013013, and rno_circRNA_016498. This result is consistent with the results of circRNA microarray analysis." 1 Analyses of circRNA and mRNA profiles in the submandibular gland in hypertension. - - rno_circRNA_002996 DOID:10763 hypertension hypertension "RT-qPCR, microarray" down-regulated "The circRNA validation results as follows: rno_circRNA_002139, rno_circRNA_002996, rno_circRNA_002997, rno_circRNA_007850, rno_circRNA_009194, rno_circRNA_009195, rno_circRNA_013013, and rno_circRNA_016498. This result is consistent with the results of circRNA microarray analysis." 1 Analyses of circRNA and mRNA profiles in the submandibular gland in hypertension. - - rno_circRNA_002997 DOID:10763 hypertension hypertension "RT-qPCR, microarray" down-regulated "The circRNA validation results as follows: rno_circRNA_002139, rno_circRNA_002996, rno_circRNA_002997, rno_circRNA_007850, rno_circRNA_009194, rno_circRNA_009195, rno_circRNA_013013, and rno_circRNA_016498. This result is consistent with the results of circRNA microarray analysis." 1 Analyses of circRNA and mRNA profiles in the submandibular gland in hypertension. - - rno_circRNA_007850 DOID:10763 hypertension hypertension "RT-qPCR, microarray" up-regulated "The circRNA validation results as follows: rno_circRNA_002139, rno_circRNA_002996, rno_circRNA_002997, rno_circRNA_007850, rno_circRNA_009194, rno_circRNA_009195, rno_circRNA_013013, and rno_circRNA_016498. This result is consistent with the results of circRNA microarray analysis." 1 Analyses of circRNA and mRNA profiles in the submandibular gland in hypertension. - - rno_circRNA_009194 DOID:10763 hypertension hypertension "RT-qPCR, microarray" down-regulated "The circRNA validation results as follows: rno_circRNA_002139, rno_circRNA_002996, rno_circRNA_002997, rno_circRNA_007850, rno_circRNA_009194, rno_circRNA_009195, rno_circRNA_013013, and rno_circRNA_016498. This result is consistent with the results of circRNA microarray analysis." 1 Analyses of circRNA and mRNA profiles in the submandibular gland in hypertension. - - rno_circRNA_009195 DOID:10763 hypertension hypertension "RT-qPCR, microarray" down-regulated "The circRNA validation results as follows: rno_circRNA_002139, rno_circRNA_002996, rno_circRNA_002997, rno_circRNA_007850, rno_circRNA_009194, rno_circRNA_009195, rno_circRNA_013013, and rno_circRNA_016498. This result is consistent with the results of circRNA microarray analysis." 1 Analyses of circRNA and mRNA profiles in the submandibular gland in hypertension. - - rno_circRNA_013013 DOID:10763 hypertension hypertension "RT-qPCR, microarray" up-regulated "The circRNA validation results as follows: rno_circRNA_002139, rno_circRNA_002996, rno_circRNA_002997, rno_circRNA_007850, rno_circRNA_009194, rno_circRNA_009195, rno_circRNA_013013, and rno_circRNA_016498. This result is consistent with the results of circRNA microarray analysis." 1 Analyses of circRNA and mRNA profiles in the submandibular gland in hypertension. - - rno_circRNA_016498 DOID:10763 hypertension hypertension "RT-qPCR, microarray" down-regulated "The circRNA validation results as follows: rno_circRNA_002139, rno_circRNA_002996, rno_circRNA_002997, rno_circRNA_007850, rno_circRNA_009194, rno_circRNA_009195, rno_circRNA_013013, and rno_circRNA_016498. This result is consistent with the results of circRNA microarray analysis." 1 Exosomal circ_DLGAP4 promotes diabetic kidney disease progression by sponging miR-143 and targeting ERBB3/NF-kappaB/MMP-2 axis. - hsa_circ_DLGAP4 - DOID:557 kidney disease diabetic kidney disease RT-qPCR up-regulated "overexpression of circ_DLGAP4 markedly promoted DKD progression in vivo via modulating miR-143/ERBB3/NF-kappaB/MMP-2. In conclusion, we indicated that exosomal circ_DLGAP4 could prove a novel insight for DKD development." 1 Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression. hsa_circ_0066659 hsa_circ_TMEM45A - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "circTMEM45A acted as a miR-65 sponge to relieve the repressive effect of miR-665 on its target IGF2. Moreover, circTMEM45A was upregulated in serum exosomes from HCC patients. circTMEM45A promotes HCC progression through the miR-665/IGF2 axis and may serve as a novel diagnostic marker and target for treatment of HCC patients." 1 Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression. hsa_circ_0001955 hsa_circ_CSNK1G1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014130)." 5 Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression. hsa_circ_0001535 hsa_circ_FAM13B - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014131)." 2 Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression. hsa_circ_0061395 hsa_circ_BACH1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014132)." 4 Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression. hsa_circ_0000502 hsa_circ_None - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014133)." 3 Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression. hsa_circ_0046366 hsa_circ_FASN - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014134)." 1 Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression. hsa_circ_0003418 hsa_circ_None - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014135)." 3 Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression. hsa_circ_0026134 hsa_circ_TUBA1C - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014136)." 2 Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression. hsa_circ_0005692 hsa_circ_GLIS2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014137)." 2 Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression. hsa_circ_0014130 hsa_circ_PIP5K1A - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014138)." 1 Circular RNA circCUL3 Accelerates the Warburg Effect Progression of Gastric Cancer through Regulating the STAT3/HK2 Axis. hsa_circ_0008309 hsa_circ_CUL3 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated "circCUL3/miR-515-5p/STAT3/HK2 axis regulation on the GC Warburg effect, providing a novel possibility for an understanding of GC pathogenesis." 1 "hsa_circ_0001955 Enhances In Vitro Proliferation, Migration, and Invasion of HCC Cells through miR-145-5p/NRAS Axis." hsa_circ_0001955 hsa_circ_CSNK1G1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "hsa_circ_0001955 Enhances In Vitro Proliferation, Migration, and Invasion of HCC Cells through miR-145-5p/NRAS Axis." 5 circNR3C1 Suppresses Bladder Cancer Progression through Acting as an Endogenous Blocker of BRD4/C-myc Complex. - hsa_circ_NR3C1 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated circNR3C1 inhibits BC progression through acting as endogenous blocker of BRD4/C-myc complex. 2 circRNA CDR1as Promotes Pulmonary Artery Smooth Muscle Cell Calcification by Upregulating CAMK2D and CNN3 via Sponging miR-7-5p. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:6432 pulmonary hypertension pulmonary hypertension RT-qPCR up-regulated the CDR1as/miR-7-5p/CNN3 and CAMK2D regulatory axis mediates HPASMC osteoblastic differentiation and calcification induced by hypoxia. This evidence reveals an approach to the treatment of PH. 1 Exosome-Shuttled circSHOC2 from IPASs Regulates Neuronal Autophagy and Ameliorates Ischemic Brain Injury via the miR-7670-3p/SIRT1 Axis. - mmu_circ_SHOC2 - DOID:6713 cerebrovascular disease ischemic stroke RT-qPCR up-regulated "our findings indicate that circSHOC2 in IPAS-EXOs suppressed neuronal apoptosis and ameliorated neuronal damage by regulating autophagy and acting on the miR-7670-3p/SIRT1 axis, which might contribute to a therapeutic strategy for ischemic stroke treatment." 1 Circular RNA circRIMS1 Acts as a Sponge of miR-433-3p to Promote Bladder Cancer Progression by Regulating CCAR1 Expression. - hsa_circ_RIMS1 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated "our research demonstrated that circRIMS1 promotes tumor growth, migration, and invasion through the miR-433-3p/CCAR1 regulatory axis, representing a potential therapeutic target and biomarker in bladder cancer." 1 circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway. - hsa_circ_PARD3 - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "Our study reveals that the novel autophagy-suppressive circPARD3 promotes LSCC progression and chemoresistance through the PRKCI-Akt-mTOR pathway, providing new insights into circRNA-mediated autophagy regulation and potential biomarker and target for LSCC treatment." 1 CircSOD2 induced epigenetic alteration drives hepatocellular carcinoma progression through activating JAK2/STAT3 signaling pathway. - hsa_circ_SOD2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated The novel signaling axis circSOD2/miR-502-5p/DNMT3a/JAK2/STAT3/circSOD2 provides a better understanding of HCC tumorigenesis. The molecular mechanism underlying this signaling axis offers new prevention and treatment of HCC. 3 The microarray identification circular RNA hsa_circ_0105015 up-regulated involving inflammation pathway in essential hypertension. hsa_circ_0105015 - - DOID:10825 essential hypertension essential hypertension RT-qPCR up-regulated Hyperexpression of hsa_circ_0105015 is a significant risk factor of EH and its association with EH involves inflammatory pathways. Hyperexpression of hsa_circ_0105015 combined with hypoexpression of hsa-miR-637 indicates vascular inflammation or endothelial dysfunction and has potential as a biomarker for early diagnosis of EH. 1 G protein-coupled oestrogen receptor promotes cell growth of non-small cell lung cancer cells via YAP1/QKI/circNOTCH1/m6A methylated NOTCH1 signalling. - hsa_circ_NOTCH1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "GPER could promote NSCLC cell growth via regulating the YAP1/QKI/circNOTCH1/m6A methylated NOTCH1 pathway, and targeting our identified molecules may be a potentially therapeutic approach to suppress NSCLC development." 1 Identification of Two Novel Circular RNAs Deriving from BCL2L12 and Investigation of Their Potential Value as a Molecular Signature in Colorectal Cancer. - hsa_circ_BCL2L12-1 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "circ-BCL2L12-2 expression is inversely associated with TNM stage, while circ-BCL2L12-1 overexpression is associated with shorter overall survival in CRC, particularly among TNM stage II patients. Overall, we identified two novel BCL2L12 circRNAs, one of which can further stratify TNM stage II patients into two subgroups with substantially distinct prognosis." 1 Identification of Two Novel Circular RNAs Deriving from BCL2L12 and Investigation of Their Potential Value as a Molecular Signature in Colorectal Cancer. - hsa_circ_BCL2L12-2 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "circ-BCL2L12-2 expression is inversely associated with TNM stage, while circ-BCL2L12-1 overexpression is associated with shorter overall survival in CRC, particularly among TNM stage II patients. Overall, we identified two novel BCL2L12 circRNAs, one of which can further stratify TNM stage II patients into two subgroups with substantially distinct prognosis." 1 Circ_SATB2 Attenuates the Anti-Tumor Role of Celastrol in Non-Small-Cell Lung Carcinoma Through Targeting miR-33a-5p/E2F7 Axis. - hsa_circ_SATB2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Cela suppressed NSCLC development through regulating circ_SATB2/miR-33a-5p/E2F7 signaling cascade. 2 Interference of circRNA HIPK3 alleviates cardiac dysfunction in lipopolysaccharide-induced mice models and apoptosis in H9C2 cardiomyocytes. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:820 myocarditis myocarditis RT-qPCR up-regulated we characterized the expression and regulation of circHIPK3 in LPS-induced myocarditis in the animal model and H9c2 cells. The results demonstrated that circHIPK3 expression is significantly upregulated when exposed to LPS in vivo and in vitro. Knockdown of circHIPK3 effectively alleviated LPS-induced myocarditis. 1 HIPK3 Circular RNA Promotes Metastases of HCC Through Sponging miR-338-3p to Induce ZEB2 Expression. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircHIPK3 plays a regulatory role in metastatic HCC by sponging miR-338-3p to induce ZEB2 expression, thus promoting EMT procession." 6 Circular RNA circ_0004507 contributes to laryngeal cancer progression and cisplatin resistance by sponging miR-873 to upregulate multidrug resistance 1 and multidrug resistance protein 1. hsa_circ_0004507 - circ_0004507 DOID:2600 laryngeal carcinoma laryngeal cancer RT-qPCR up-regulated "Knockdown of circ_0004507 inhibited laryngeal cancer progression and cisplatin resistance by sponging miR-873, providing a potential target for laryngeal cancer therapy." 1 "Hsa_circ_0006872 promotes cigarette smoke-induced apoptosis, inflammation and oxidative stress in HPMECs and BEAS-2B cells through the miR-145-5p/NF-kappaB axis." hsa_circ_0006872 hsa_circ_ASCC3 - DOID:3083 chronic obstructive pulmonary disease chronic obstructive pulmonary disease RT-qPCR up-regulated "Hsa_circ_0006872 promotes cigarette smoke-induced apoptosis, inflammation and oxidative stress in HPMECs and BEAS-2B cells through the miR-145-5p/NF-kappaB axis." 1 Oxidized low-density lipoprotein accelerates the injury of endothelial cells via circ-USP36/miR-98-5p/VCAM1 axis. - hsa_circ_USP36 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Ox-LDL promoted the apoptosis and inflammation but suppressed the viability of HUVEC cells through upregulating circ-USP36, thus elevating the expression of VCAM1 via miR-98-5p." 7 Tumor promoting effects of circRNA_001287 on renal cell carcinoma through miR-144-targeted CEP55. - - circRNA_001287 DOID:4451 renal carcinoma renal carcinoma "RT-qPCR, microarray" up-regulated "circ_001287 can up-regulate CEP55 by binding to miR-144, which resulted in increased proliferative, invasive and migratory capacities and tumor growth in vivo." 1 Circular RNA 100146 Promotes Colorectal Cancer Progression by the MicroRNA 149/HMGA2 Axis. - - Circular RNA 100146 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circRNA 100146 knockdown repressed proliferation, enhanced apoptosis, and hindered migration and invasion in SW620 and SW480 cells through targeting the miR-149/HMGA2 axis." 1 "Circ-UBR1 facilitates proliferation, metastasis, and inhibits apoptosis in breast cancer by regulating the miR-1299/CCND1 axis." - hsa_circ_UBR1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circ-UBR1 might play a pro-cancer role in BC progression by regulating the miR-1299/CCND1 axis. 3 "Circular RNA circGSK3B Promotes Cell Proliferation, Migration, and Invasion by Sponging miR-1265 and Regulating CAB39 Expression in Hepatocellular Carcinoma." - hsa_circ_GSK3B - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "circGSK3B-miR-1265-CAB39 axis can promote the proliferation, migration, invasion of HCC cells, indicating that circGSKB may serve as a promising diagnostic and prognostic marker in HCC." 1 Circular RNA hsa_circ_0000658 inhibits osteosarcoma cell proliferation and migration via the miR-1227/IRF2 axis. hsa_circ_0000658 hsa_circ_MCTP2 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated Circular RNA hsa_circ_0000658 inhibits osteosarcoma cell proliferation and migration via the miR-1227/IRF2 axis. 1 "A novel circular RNA, circXPO1, promotes lung adenocarcinoma progression by interacting with IGF2BP1." - hsa_circ_XPO1 - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated "circXPO1 could bind with IGF2BP1 and enhance CTNNB1 mRNA stability, and subsequently promote LUAD progression." 1 A novel circular RNA hsa_circRNA_103809/miR-377-3p/GOT1 pathway regulates cisplatin-resistance in non-small cell lung cancer (NSCLC). - - hsa_circRNA_103809 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Analysis of data suggested that targeting the hsa_circRNA_103809/miR-377-3p/GOT1 pathway increased susceptibility of CR-NSCLC cells to cisplatin, and this study provided novel targets to improve the therapeutic efficacy of cisplatin for NSCLC treatment in clinic." 1 Circ-PRMT5 promotes breast cancer by the miR-509-3p/TCF7L2 axis activating the PI3K/AKT pathway. - hsa_circ_PRMT5 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Functionally, knockdown of circ-PRMT5 suppresses cell proliferation and angiogenesis and increases cell apoptosis in breast cancer. Mechanistically, we identified that circ-PRMT5 up-regulates TCF7L2 expression by acting as a miR-509-3p sponge. The negative expression correlation between miR-509-3p and circ-PRMT5 or TCF7L2 in clinical tissues was further demonstrated." 2 CircRNA-1806 Decreases T Cell Apoptosis and Prolongs Survival of Mice After Cryptococcal Infection by Sponging miRNA-126. - - CircRNA-1806 DOID:0080159 cryptococcal meningitis cryptococcal meningitis "RT-qPCR, microarray" down-regulated CircRNA-1806 Decreases T Cell Apoptosis and Prolongs Survival of Mice After Cryptococcal Infection by Sponging miRNA-126. 1 Circular RNA hsa_circ_0005114-miR-142-3p/miR-590-5p-adenomatous polyposis coli protein axis as a potential target for treatment of glioma. hsa_circ_0005114 hsa_circ_RIMS2 - DOID:0060108 brain glioma glioma RNA-seq down-regulated "hsa-miR-142-3p/hsa-miR-590-5p-APC-related circ/ceRNA axes may be important in glioma, and hsa_circ_0005114 interacted with both of these miRNAs. Functional analysis showed that hsa_circ_0005114 was involved in insulin secretion, while APC was associated with the Wnt signaling pathway." 1 Hsa_circ_0002483 regulates miR-758-3p/MYC axis to promote acute myeloid leukemia progression. hsa_circ_0002483 - circ_0002483 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated miR-758-3p overexpression restrained cell proliferation and promoted cycle arrest and apoptosis via decreasing MYC. Circ_0002483 knockdown repressed AML cell proliferation and promoted cycle arrest and apoptosis via controlling miR-758-3p/MYC axis. 1 "Circular RNA circ_ASAP2 promotes cell viability, migration, and invasion of gastric cancer cells by regulating the miR-770-5p/CDK6 axis." - hsa_circ_ASAP2 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Circ_ASAP2 knockdown can repress the development of GC cells partly through regulating the miR-770-5p/CDK6 axis, suggesting an underlying circRNA-targeted therapy for GC treatment." 3 Circ_0025033 promotes the progression of ovarian cancer by activating the expression of LSM4 via targeting miR-184. hsa_circ_0025033 - Circ_0025033 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Circ_0025033 promotes the progression of OC by regulating LSM4 expression via targeting miR-184, which provided a new strategy to treat OC." 4 Circ0120816 acts as an oncogene of esophageal squamous cell carcinoma by inhibiting miR-1305 and releasing TXNRD1. hsa_circ_0120816 - Circ0120816 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, microarray" up-regulated circ0120816 played an active role in promoting ESCC development by targeting miR-1305 and upregulating oncogene TXNRD1. 1 Exosome-transferred hsa_circ_0014235 promotes DDP chemoresistance and deteriorates the development of non-small cell lung cancer by mediating the miR-520a-5p/CDK4 pathway. hsa_circ_0014235 hsa_circ_S100A2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Exosome-transferred hsa_circ_0014235 promotes DDP chemoresistance and deteriorates the development of non-small cell lung cancer by mediating the miR-520a-5p/CDK4 pathway. 2 "CircSMYD4 regulates proliferation, migration and apoptosis of hepatocellular carcinoma cells by sponging miR-584-5p." - hsa_circ_SMYD4 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Up-regulation of circSMYD4 inhibited the proliferation, invasion and migration and promoted the apoptosis of HCC cells in vitro, while it inhibited tumor growth, promoted apoptosis-related proteins, and suppressed alpha-fetoprotein (AFP) levels in vivo. CircSMYD4 could be used as a miRNA sponge to target miR-584-5p. In addition, miR-584-5p overexpression partially reversed the regulatory effect of circSMYD4 on HCC." 3 Circ_0015756 promotes the progression of ovarian cancer by regulating miR-942-5p/CUL4B pathway. hsa_circ_0015756 - Circ_0015756 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated CircSMYD4 prevents the development of HCC through regulating multiple signaling pathways such as metastasis and apoptosis by sponging miR-584-5p. 2 TRPS1 and YAP1 Regulate Cell Proliferation and Drug Resistance of Osteosarcoma via Competitively Binding to the Target of circTADA2A - miR-129-5p. - hsa_circ_TADA2A circTADA2A DOID:3347 osteosarcoma Osteosarcoma RT-qPCR up-regulated "CircRNA TADA2A could target miR-129-5p, which was competitively bound by TRPS1 and YAP1, thereby regulating OS cell proliferation and drug resistance" 2 Circ-EEF2 facilitated autophagy via interaction with mir-6881-3p and ANXA2 in EOC. - hsa_circ_EEF2 - DOID:2152 ovary epithelial cancer epithelial ovarian cancer RT-qPCR up-regulated "circEEF2 could directly bind with ANXA2 to inhibit the expression of p-mTOR. In conclusion, findings of the current study illustrate that circEEF2 promoted autophagy, proliferation, and invasion of EOC by interacting with miR-6881-3p and ANXA2." 1 "Circular RNA circPLK1 promotes breast cancer cell proliferation, migration and invasion by regulating miR-4500/IGF1 axis." - hsa_circ_PLK1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "CircPLK1 silence inhibited BC cell growth, migration and invasion by regulating miR-4500/IGF1 axis, suggesting circPLK1/miR-4500/IGF axis might be a potential therapeutic target." 1 Circular RNA Circ-BANP Regulates Oxidized Low-density Lipoprotein-induced Endothelial Cell Injury Through Targeting the miR-370/Thioredoxin-interacting Protein Axis. hsa_circ_0040824 hsa_circ_BANP circ-BANP DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Our findings demonstrated that circ-BANP regulated ox-LDL-induced cell injury in HUVECs at least in part through targeting the miR-370/TXNIP axis, illuminating circ-BANP as a potential target for AS detection and treatment." 1 "Hsa_circ_0001445 inhibits ox-LDL-induced HUVECs inflammation, oxidative stress and apoptosis by regulating miRNA-640." hsa_circ_0001445 - circ_0001445 DOID:178 vascular disease inflammatory RT-qPCR down-regulated "Our findings concluded that Hsa_circ_0001445 inhibits ox-LDL-induced HUVEC inflammation, oxidative stress and apoptosis by regulating miRNA-640." 1 Circ_0003998 enhances doxorubicin resistance in hepatocellular carcinoma by regulating miR-218-5p/EIF5A2 pathway. hsa_circ_0003998 - Circ_0003998 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0003998 knockdown sensitized HCC cell to DOX by regulating miR-218-5p/EIF5A2 axis, indicating new markers of poor response to DOX and potential therapeutic strategies for the chemotherapy of HCC." 3 Circular RNA hsa_circ_0001829 promotes gastric cancer progression through miR-155-5p/SMAD2 axis. hsa_circ_0001829 hsa_circ_TCONS_00015535 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "our findings firstly demonstrated a novel oncogenic role of hsa_circ_0001829 in GC progression through miR-155-5p-SMAD2 axis, and our study may offer novel biomarkers and therapeutic targets for GC." 1 CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression. - hsa_circ_CDKN2B-AS1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circCDKN2B-AS1 facilitates aerobic glycolysis by sponging the IMP3 protein to stabilize HK2 mRNA, consequently promoting the malignant phenotype in cervical cancer, which may provide a potential approach for cervical cancer therapeutics." 1 "CircLRRK1 targets miR-223-3p to inhibit the proliferation, migration and invasion of trophoblast cells by regulating the PI3K/AKT signaling pathway." - hsa_circ_LRRK1 - DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated "CircLRRK1 could suppress the proliferation, migration and invasion of trophoblast cells by regulating the PI3K/AKT signaling pathway via targeting miR-223-3p, suggesting that circLRRK1 might be a potential biomarker for the treatment of PE." 1 CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/beta-catenin pathway. - - hsa_circRNA_104348 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circular RNA hsa_circRNA_104348 might function as a competing endogenous RNA (ceRNA) to promotes HCC progression by targeting miR-187-3p/RTKN2 axis and activating Wnt/beta-catenin pathway. 1 Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer detection. hsa_circ_0001900 hsa_circ_CAMSAP1 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "We ultimately determined that hsa_circ_0001900, hsa_circ_0001178, and hsa_circ_0005927 were upregulated in the plasma of CRC patients relative to healthy controls and were correlated with clinicopathological findings in these patients." 2 Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer detection. hsa_circ_0001178 hsa_circ_USP25 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "We ultimately determined that hsa_circ_0001900, hsa_circ_0001178, and hsa_circ_0005928 were upregulated in the plasma of CRC patients relative to healthy controls and were correlated with clinicopathological findings in these patients." 3 Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer detection. hsa_circ_0005927 hsa_circ_VDAC3 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "We ultimately determined that hsa_circ_0001900, hsa_circ_0001178, and hsa_circ_0005929 were upregulated in the plasma of CRC patients relative to healthy controls and were correlated with clinicopathological findings in these patients." 2 circEYA1 Functions as a Sponge of miR-582-3p to Suppress Cervical Adenocarcinoma Tumorigenesis via Upregulating CXCL14. - hsa_circ_EYA1 - DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" up-regulated circEYA1 Functions as a Sponge of miR-582-3p to Suppress Cervical Adenocarcinoma Tumorigenesis via Upregulating CXCL14. 1 circRASGRF2 functions as an oncogenic gene in hepatocellular carcinoma by acting as a miR-1224 sponge. hsa_circ_0073181 hsa_circ_RASGRF2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated circRASGRF2 functions as an oncogenic gene in hepatocellular carcinoma by acting as a miR-1224 sponge. 2 Circular RNA Circ-03955 Promotes Epithelial-Mesenchymal Transition in Osteosarcoma by Regulating miR-3662/Metadherin Pathway. - - Circ-03955 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Mechanism analysis revealed that circ-03955 could bind to miR-3662, and the latter could target MTDH, leading to its suppressed expression and facilitating epithelial-mesenchymal transition (EMT). All these findings demonstrate that the presence of circ-03955 promotes EMT in osteosarcoma by acting as miR-3662 sponge-mediated MTDH expression." 1 Comprehensive analysis of circular RNA in oral leukoplakia: upregulated circHLA-C as a potential biomarker for diagnosis and prognosis. - hsa_circ_HLA-C - DOID:9655 oral mucosa leukoplakia oral leukoplakia "RT-qPCR, RNA-seq" up-regulated circHLA-C as a promising diagnostic biomarker with potential as a therapeutic genetic target for OLK. 1 circARRDC3 contributes to interleukin_13__nduced inflammatory cytokine and mucus production in nasal epithelial cells via the miR_375/KLF4 axis. - hsa_circ_ARRDC3 circARRDC3 DOID:4483 rhinitis rhinitis RT-qPCR up-regulated "In conclusion, circARRDC3 contributed to the development of AR by regulating the miR_375/KLF4 axis. These findings may provide novel insights into the pathogenesis of AR." 1 circ_100984-miR-432-3p axis regulated c-Jun/YBX-1/beta-catenin feedback loop promotes bladder cancer progression. - - Circ_100984 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circ_100984-miR-432-3p axis regulated c-Jun/YBX-1/beta-catenin feedback loop promotes BC progression, providing a potential therapeutic axis for BC progression." 1 Circ_0005198 enhances temozolomide resistance of glioma cells through miR-198/TRIM14 axis. hsa_circ_0005198 - circ_0005198 DOID:0060108 brain glioma glioma RT-qPCR up-regulated circ_0005198-miR-198-TRIM14 regulatory pathway is critical to TMZ resistance of glioma. 2 CircRNA_0000392 promotes colorectal cancer progression through the miR-193a-5p/PIK3R3/AKT axis. hsa_circ_0000392 - circRNA_0000392 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated CircRNA_0000392 functions as an oncogene through the miR-193a-5p/PIK3R3/Akt axis in CRC cells. 1 Circular RNA hsa_circ_0008003 facilitates tumorigenesis and development of non-small cell lung carcinoma via modulating miR-488/ZNF281 axis. hsa_circ_0008003 hsa_circ_LDB2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ-0008003 triggered tumour formation in NSCLC, which was adjusted via miR-488/ZNF281 axis." 4 CircPUM1 promotes hepatocellular carcinoma progression through the miR-1208/MAP3K2 axis. - hsa_circ_PUM1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circPUM1 could promote the development of HCC by up-regulating the expression of MAP3K2 via sponging miR-1208. 1 Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades. hsa_circ_0000915 hsa_circ_FKBP8 - DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" up-regulated "Our findings indicated that 4 circRNAs (hsa_circ_0000915, hsa_circ_0127664, hsa_circ_0008362, and hsa_circ_0001467) are associated with the pathological characteristics of glioma and revealed critical regulatory functions at multiple levels. The results presented here might provide vital molecular biomarkers and potential therapeutic targets for glioma." 2 Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades. hsa_circ_0127664 hsa_circ_KCNN2 - DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" up-regulated "Our findings indicated that 4 circRNAs (hsa_circ_0000915, hsa_circ_0127664, hsa_circ_0008362, and hsa_circ_0001468) are associated with the pathological characteristics of glioma and revealed critical regulatory functions at multiple levels. The results presented here might provide vital molecular biomarkers and potential therapeutic targets for glioma." 1 Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades. hsa_circ_0008362 hsa_circ_FBXW4 - DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" up-regulated "Our findings indicated that 4 circRNAs (hsa_circ_0000915, hsa_circ_0127664, hsa_circ_0008362, and hsa_circ_0001469) are associated with the pathological characteristics of glioma and revealed critical regulatory functions at multiple levels. The results presented here might provide vital molecular biomarkers and potential therapeutic targets for glioma." 1 Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades. hsa_circ_0001467 hsa_circ_MARCH6 - DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" up-regulated "Our findings indicated that 4 circRNAs (hsa_circ_0000915, hsa_circ_0127664, hsa_circ_0008362, and hsa_circ_0001470) are associated with the pathological characteristics of glioma and revealed critical regulatory functions at multiple levels. The results presented here might provide vital molecular biomarkers and potential therapeutic targets for glioma." 1 Hsa_circ_0000069 Knockdown Inhibits Tumorigenesis and Exosomes with Downregulated hsa_circ_0000069 Suppress Malignant Transformation via Inhibition of STIL in Pancreatic Cancer. hsa_circ_0000069 hsa_circ_STIL - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated hsa_circ_0000069 knockdown could inhibit pancreatic cancer tumorigenesis and exosomes with downregulated hsa_circ_0000069 could suppress HPDE cell malignant transformation. 1 CircRNA_102272 Promotes Cisplatin-Resistance in Hepatocellular Carcinoma by Decreasing MiR-326 Targeting of RUNX2. - - circRNA_102272 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated CircRNA_102272 is significantly increased in HCC tissues and cells and promotes HCC cell proliferation and cisplatin-resistance. 1 Cisplatin-resistant osteosarcoma cell-derived exosomes confer cisplatin resistance to recipient cells in an exosomal circ_103801-dependent manner. - - circ_103801 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated serum exosomal hsa_circ_103801 may serve as an effective prognostic biomarker for OS. 1 Differential expression of circular RNAs in bone marrow-derived exosomes from essential thrombocythemia patients. - hsa_circ_DAP3 - DOID:2224 essential thrombocythemia essential thrombocythemia RNA-seq up-regulated "circDAP3, circASXL1 and circRUNX1 were significantly down-regulated in ET patients when compared with healthy people. And we confirmed that circ_0014614 could inhibit K562 cells differentiate into megakaryocytes." 1 Differential expression of circular RNAs in bone marrow-derived exosomes from essential thrombocythemia patients. - hsa_circ_ASXL1 - DOID:2224 essential thrombocythemia essential thrombocythemia RNA-seq up-regulated "circDAP3, circASXL1 and circRUNX1 were significantly down-regulated in ET patients when compared with healthy people. And we confirmed that circ_0014614 could inhibit K562 cells differentiate into megakaryocytes." 1 Differential expression of circular RNAs in bone marrow-derived exosomes from essential thrombocythemia patients. - hsa_circ_RUNX1 - DOID:2224 essential thrombocythemia essential thrombocythemia RNA-seq up-regulated "circDAP3, circASXL1 and circRUNX1 were significantly down-regulated in ET patients when compared with healthy people. And we confirmed that circ_0014614 could inhibit K562 cells differentiate into megakaryocytes." 1 [Over-expression of circNR4A1/Hsa-circ-0026352 inhibits proliferation and induces apoptosis in MCF-7 cells]. hsa_circ_0026352 hsa_circ_NR4A1 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated Over-expression of circNR4A1 can inhibit cell proliferation and induce cell apoptosis in MCF-7 cells. 1 "Identification, biogenesis and function prediction of novel circRNA during the chicken ALV-J infection." - - circRNA_3079 DOID:4492 avian influenza chicken alv-j infection RNA-seq up-regulated "Bioinformatics analysis results showed that circRNA_3079 and the predicted target genes are enriched in many pathways related to immunity or tumors, such as p53 signaling pathway, JakSTAT signaling pathway and NODlike receptor signaling pathway, which revealed that circRNA_3079 may indirectly regulate the ALV-J infection process through the regulation of target genes." 1 "Association study of hsa_circ_0001946, hsa-miR-7-5p and PARP1 in coronary atherosclerotic heart disease." hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:0080938 nonobstructive coronary artery disease coronary atherosclerotic heart disease RT-qPCR up-regulated "The present work demonstrated the predictive power of hsa_circ_0001946, hsa-miR-7-5p and PARP1 as combined biomarkers for CHD, and suggests a regulatory axis they consisted might contribute to the CHD development." 1 CircDUSP16 Contributes to Cell Development in Esophageal Squamous Cell Carcinoma by Regulating miR-497-5p/TKTL1 Axis. - hsa_circ_DUSP16 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "CircDUSP16 knockdown suppressed hypoxia-induced ESCC cell growth, invasion, and glycolysis by regulating TKTL1 expression through sponging miR-497-5p." 1 Diagnostic and Therapeutic Value of Hsa_circ_0002594 for T Helper 2-Mediated Allergic Asthma. hsa_circ_0002594 hsa_circ_ELF2 - DOID:9415 allergic asthma allergic asthma "RT-qPCR, RNA-seq" up-regulated hsa_circ_0002594 was upregulated in CD4+ T cells and might have potential value in the diagnosis and treatment of Th2-mediated allergic asthma. 1 Circular RNA 0001313 Knockdown Suppresses Non-Small Cell Lung Cancer Cell Proliferation and Invasion via the microRNA-452/HMGB3/ERK/MAPK Axis. hsa_circ_0001313 - circ0001313 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ0001313 blunted the ERK/MAPK pathway via the miR-452/HMGB3 axis. 1 Expression Profile of Circular RNAs in Oral Squamous Cell Carcinoma. - hsa_circ_TNNI3K circRNA0001766 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated knocking down circRNA0001766 inhibited the expression of VEGFA and the proliferation of OSCC cells. 1 "CircASH2L Promotes Ovarian Cancer Tumorigenesis, Angiogenesis, and Lymphangiogenesis by Regulating the miR-665/VEGFA Axis as a Competing Endogenous RNA." - hsa_circ_ASH2L - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "circASH2L plays a critical role in regulating ovarian cancer cell tumorigenesis, angiogenesis, and lymphangiogenesis through the miR-665/VEGFA axis." 1 Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases. - hsa_circ_ITGA7 - DOID:4079 heart valve disease valvular heart diseases "RT-qPCR, RNA-seq" up-regulated "This study provided a preliminary landscaping of circRNAs expression profiles which are involved in persistent AF due to VHD, and established the probability for future related researches in this field." 1 Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases. - hsa_circ_KCNN2 - DOID:4079 heart valve disease valvular heart diseases "RT-qPCR, RNA-seq" up-regulated "This study provided a preliminary landscaping of circRNAs expression profiles which are involved in persistent AF due to VHD, and established the probability for future related researches in this field." 1 Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases. - hsa_circ_MIB1 - DOID:4079 heart valve disease valvular heart diseases "RT-qPCR, RNA-seq" up-regulated "This study provided a preliminary landscaping of circRNAs expression profiles which are involved in persistent AF due to VHD, and established the probability for future related researches in this field." 1 Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases. - hsa_circ_BARD1 - DOID:4079 heart valve disease valvular heart diseases "RT-qPCR, RNA-seq" up-regulated "This study provided a preliminary landscaping of circRNAs expression profiles which are involved in persistent AF due to VHD, and established the probability for future related researches in this field." 1 Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases. - hsa_circ_LAMA2 - DOID:4079 heart valve disease valvular heart diseases "RT-qPCR, RNA-seq" up-regulated "This study provided a preliminary landscaping of circRNAs expression profiles which are involved in persistent AF due to VHD, and established the probability for future related researches in this field." 1 Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases. - hsa_circ_RYR2 - DOID:4079 heart valve disease valvular heart diseases "RT-qPCR, RNA-seq" up-regulated "This study provided a preliminary landscaping of circRNAs expression profiles which are involved in persistent AF due to VHD, and established the probability for future related researches in this field." 1 Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases. - hsa_circ_ANO5 - DOID:4079 heart valve disease valvular heart diseases "RT-qPCR, RNA-seq" up-regulated "This study provided a preliminary landscaping of circRNAs expression profiles which are involved in persistent AF due to VHD, and established the probability for future related researches in this field." 1 Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases. - hsa_circ_TNNI3K - DOID:4079 heart valve disease valvular heart diseases "RT-qPCR, RNA-seq" up-regulated "This study provided a preliminary landscaping of circRNAs expression profiles which are involved in persistent AF due to VHD, and established the probability for future related researches in this field." 1 "Knockdown of circ_0006528 Suppresses Cell Proliferation, Migration, Invasion, and Adriamycin Chemoresistance via Regulating the miR-1236-3p/CHD4 Axis in Breast Cancer." hsa_circ_0006528 - circ_0006528 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Downregulation of circ_0006528 restrained cell proliferation, migration, invasion, and drug resistance of ADM-resistant BCa cells through inhibiting CHD4 and inducing miR-1236-3p." 4 circ_0067934: A Potential Biomarker and Therapeutic Target for Hepatocellular Carcinoma. hsa_circ_0067934 - circ_0067934 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ_0067934 may function as a potential biomarker for the diagnosis and prognosis of HCC. 2 A Circular RNA Derived from Golgi Glycoprotein 1 mRNA Regulates KRAS Expression and Promotes Colorectal Cancer Progression by Targeting microRNA-622. - hsa_circ_GLG1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_GLG1 promoted KRAS expression at both the mRNA and protein levels by acting as an miR-622 sponge. 1 Oxidative Stress-Induced circHBEGF Promotes Extracellular Matrix Production via Regulating miR-646/EGFR in Human Trabecular Meshwork Cells. - hsa_circ_HBEGF - DOID:1070 primary open angle glaucoma primary open-angle glaucoma "RT-qPCR, microarray" up-regulated circHBEGF could competitively bind to miR-646 as a miRNA sponge to regulate EGFR expression in HTMCs. 1 Circular RNA circ_SETD2 represses breast cancer progression via modulating the miR-155-5p/SCUBE2 axis. - hsa_circ_SETD2 circ_SETD2 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circ_SETD2 curbed BC progression via upregulating SCUBE2 via binding to miR-155-5p. 2 "Circular RNA hsa_circ_0007121 regulates proliferation, migration, invasion, and epithelial-mesenchymal transition of trophoblast cells by miR-182-5p/PGF axis in preeclampsia." hsa_circ_0007121 hsa_circ_None - DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated Hsa_circ_0007121 mediated the progression of PE via miR-182-5p/PGF axis. 2 Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p. hsa_circ_0000034 - circ_0000034 DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated circ_0000034 knockdown suppressed the development of RB by the modulation of miR-361-3p/STX17 axis. 3 Circular RNA ZNF292 affects proliferation and apoptosis of hepatocellular carcinoma cells by regulating Wnt/beta-catenin pathway. - hsa_circ_ZNF292 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Knock downing circRNA ZNF292 leads to cell cycle arrest in G1 phase, thus suppressing cell proliferation and promoting cell apoptosis." 2 Circ-ABCB10 promotes growth and metastasis of nasopharyngeal carcinoma by upregulating ROCK1. - hsa_circ_ABCB10 circ-ABCB10 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated circ-ABCB10 promoted NPC cell proliferation and metastasis via upregulating ROCK1 in vitro. 1 CircRNA_100395 protects breast carcinoma deterioration by targeting MAPK6. - - circRNA_100395 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated CircRNA_100395 serves as an anti-cancer gene in breast carcinoma progression by targeting MAPK6. 1 "Hsa_circ_0000337 promotes proliferation, migration and invasion in glioma by competitively binding miRNA-942-5p and thus upregulates MAT2A." hsa_circ_0000337 hsa_circ_PPFIA1 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "hsa_circ_0000337 sponged miRNA-942-5p to upregulate MAT2A, thus inducing the malignant phenotypes of glioma." 1 Three CircRNAs Function as Potential Biomarkers for Colorectal Cancer. - hsa_circ_FMN2 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ-FMN2, circ-LMNB1, and circ-ZNF609 may function as potential diagnostic and prognostic indicators for CRC detection." 4 Three CircRNAs Function as Potential Biomarkers for Colorectal Cancer. - hsa_circ_LMNB1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ-FMN2, circ-LMNB1, and circ-ZNF609 may function as potential diagnostic and prognostic indicators for CRC detection." 2 Three CircRNAs Function as Potential Biomarkers for Colorectal Cancer. - hsa_circ_ZNF609 circ-ZNF609 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ-FMN2, circ-LMNB1, and circ-ZNF609 may function as potential diagnostic and prognostic indicators for CRC detection." 3 CircAMOTL1 Promotes Tumorigenesis Through miR-526b/SIK2 Axis in Cervical Cancer. - hsa_circ_AMOTL1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circAMOTL1 exerted an oncogenic role in cervical cancer progression through sponging miR-526b. 3 HSA_CIRC_0004050 on proliferation and apoptosis of A549 cells through ERK/JNK signaling pathway. hsa_circ_0004050 hsa_circ_PKD2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "hsa_circ_0004050 could markedly increase the protein expression of DUSP9 via targeting miR-1233-3p in A549 cells, thereby inhibiting the ERK/JNK signaling pathway." 1 Circular RNA ITCH mediates H(2)O(2)-induced myocardial cell apoptosis by targeting miR-17-5p via wnt/beta-catenin signalling pathway. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:1287 cardiovascular system disease cardiovascular disease RT-qPCR up-regulated Circ-ITCH could protect myocardial cells from injuries caused by H2O2 by suppressing apoptosis while miR-17-5p played a reverse role. 1 Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in Endometrial Carcinoma. hsa_circ_0075960 hsa_circ_None - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated hsa_circ_0075960 functioned as a sponge for miR-361-3p/SH2B1 in EC cells and regulated the progression of EC through the modulation of miR-361-3p. 2 Circ-CCS is identified as a cancer-promoting circRNA in lung cancer partly by regulating the miR-383/E2F7 axis. - hsa_circ_CCS circ-CCS DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Circ-CCS was shown to facilitate lung cancer progression via the miR-383/E2F7 axis. 1 "Circ_DHRS3 positively regulates GREM1 expression by competitively targeting miR-183-5p to modulate IL-1beta-administered chondrocyte proliferation, apoptosis and ECM degradation." - hsa_circ_DHRS3 circ_DHRS3 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Circ_DHRS3 mediated IL-1beta-administered chondrocyte proliferation, apoptosis and ECM degradation by positively regulating GREM1 expression via competitively targeting miR-183-5p." 2 CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1. - hsa_circ_SORE "circRNA-SORE, circRNA_104797" DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated silencing circRNA-SORE by injection of siRNA could substantially overcome sorafenib resistance. 2 CircRNA_ACAP2 Suppresses EMT in Head and Neck Squamous Cell Carcinoma by Targeting the miR-21-5p/STAT3 Signaling Axis. - hsa_circ_ACAP2 - DOID:5520 head and neck squamous cell carcinoma head and neck squamous cell carcinoma RT-qPCR up-regulated CircRNA_ACAP2 functions as a tumor suppressor gene in HNSCC and that its function is regulated via the miR-21-5p/STAT3 signaling axis. 1 Hsa_circ_0046263 Drives the Carcinogenesis and Metastasis of Non-Small Cell Lung Cancer Through the Promotion of NOVA2 by Absorbing Mir-940 as a Molecular Sponge. hsa_circ_0046263 hsa_circ_P4HB - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Hsa_circ_0046263 was identified as a cancer-promoting factor in NSCLC via sponging miR-940 and upregulating NOVA2. 2 Circ-PRKDC Facilitates the Progression of Colorectal Cancer Through miR-198/DDR1 Regulatory Axis. - hsa_circ_PRKDC circ-PRKDC DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Knockdown of circ-PRKDC inhibited CRC progression via modulating miR-198/DDR1 pathway. 4 "CircPVT1 Regulates Cell Proliferation, Apoptosis and Glycolysis in Hepatocellular Carcinoma via miR-377/TRIM23 Axis." - hsa_circ_PVT1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated CircPVT1 aggravated the progression of HCC by upregulating TRIM23 via sponging miR-377. 3 Circular RNA circ_DROSHA alleviates the neural damage in a cell model of temporal lobe epilepsy through regulating miR-106b-5p/MEF2C axis. - hsa_circ_DROSHA - DOID:3328 temporal lobe epilepsy temporal lobe epilepsy RT-qPCR down-regulated enforced expression of circ_DROSHA alleviated the cell damage of the TLE cell model at least in part through the regulation of the miR-106b-5p/MEF2C axis. 1 CircASPH promotes KGN cells proliferation through miR-375/MAP2K6 axis in Polycystic Ovary Syndrome. - hsa_circ_ASPH - DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RT-qPCR up-regulated circASPH promotes KGN cells proliferation through miR-375/MAP2K6 axis in PCOS. 1 N(6) -methyladenosine modification of circular RNA circ-ARL3 facilitates Hepatitis B virus-associated hepatocellular carcinoma via sponging miR-1305. - hsa_circ_ARL3 circ-ARL3 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq up-regulated "circ-ARL3 is a critical regulator in HBV-related HCC, targeting the axis of circ-ARL3/miR-1305 may be a promising treatment for HBV+ HCC patients." 1 Profiling and Integrated Analysis of Differentially Expressed Circular RNAs in Plasma Exosomes as Novel Biomarkers for Advanced-Stage Lung Adenocarcinoma. hsa_circ_0102537 - - DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" down-regulated "We identified hsa_circ_0102537 to be downregulated in both LUAD plasma exosomes and tissues. GO, KEGG pathway analysis, circRNA-miRNA-mRNA meshwork, and further experiments suggest that hsa_circ_0102537 could be involved in LUAD progression." 1 hsa_circRNA_000166 Facilitated Cell Growth and Limited Apoptosis through Targeting miR-326/LASP1 Axis in Colorectal Cancer. hsa_circ_000166 - hsa_circRNA_000166 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated downregulation of hsa_circRNA_000166 inhibited the cell growth and facilitated apoptosis during CRC development by sponging the miR-326/LASP1 pathway. 1 circPHIP promotes oral squamous cell carcinoma progression by sponging miR-142-5p and regulating PHIP and ACTN4 expression. - hsa_circ_PHIP - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated circPHIP is overexpressed in OSCC and enhances its malignancy via an miR-142-5p/PHIP-ACTN4/AKT serine/threonine kinase 1 signaling axis. 1 Circular RNA circHIPK3 as a novel circRNA regulator of autophagy and endothelial cell dysfunction in atherosclerosis. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated CircHIPK3 could inhibit lipid content in ox-LD-treated HUVECs via activating autophagy. 2 Knockdown of Circular RNA Hsa_circ_0000714 Can Regulate RAB17 by Sponging miR-370-3p to Reduce Paclitaxel Resistance of Ovarian Cancer Through CDK6/RB Pathway. hsa_circ_0000714 hsa_circ_AARS - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Hsa_circ_0000714 acts as a sponge for miR-370-3p, and regulates RAB17 expression through the CDK6/RB signaling pathway." 1 circBICD2 targets miR-149-5p/IGF2BP1 axis to regulate oral squamous cell carcinoma progression. - hsa_circ_BICD2 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "circBICD2 knockdown repressed OSCC cell proliferation, migration, invasion, and glutaminolysis and increased apoptosis via modulating miR-149-5p/IGF2BP1 axis, which might act as a potential target for OSCC treatment." 3 CircRNA-100284 activates aurora kinase B by inducing methylation of HSP70 via microRNA-217 to promote proliferation of bladder cancer cells. - - CircRNA-100284 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated CircRNA-100284 activates aurora kinase B by inducing methylation of HSP70 via microRNA-217 to promote the proliferation of bladder cancer cells. 1 Circ_0001247 functions as a miR-1270 sponge to accelerate cervical cancer progression by up-regulating ZEB2 expression level. hsa_circ_0001247 - Circ_0001247 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Circ_0001247 promotes progression of CC by sponging miR-1270 to upregulate ZEB2 expression level. 1 Circ_PGPEP1 Serves as a Sponge of miR-1297 to Promote Gastric Cancer Progression via Regulating E2F3. - hsa_circ_PGPEP1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_PGPEP1 Serves as a Sponge of miR-1297 to Promote Gastric Cancer Progression via Regulating E2F3. 1 Circular PVT1 regulates cell proliferation and invasion via miR-149-5p/FOXM1 axis in ovarian cancer. - hsa_circ_PVT1 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated circular PVT1 increased FOXM1 level via binding to miR-149-5p and thus affected ovarian cancer cell viability and migration. 1 Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR. - hsa_circ_DLC1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated "circDLC1, a downstream target of KIAA1429, is a promising prognostic marker for HCC patients, and the circDLC1-HuR-MMP1 axis may serve as a potential therapeutic target for HCC treatment." 1 Circ-ZDHHC5 Accelerates Esophageal Squamous Cell Carcinoma Progression in vitro via miR-217/ZEB1 Axis. - hsa_circ_ZDHHC5 circ-ZDHHC5 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated circ-ZDHHC5 could impact on ESCC progression by sponging miR-217 with ZEB1. 1 "Circ_0061012 contributes to IL-22-induced proliferation, migration and invasion in keratinocytes through miR-194-5p/GAB1 axis in psoriasis." hsa_circ_0061012 - Circ_0061012 DOID:8893 psoriasis psoriasis RT-qPCR up-regulated Circ_0061012 elevated the expression of GAB1 through sponging miR-194-5p in HaCaT cells. Circ_0061012 accelerated IL-22-induced proliferation and metastasis in HaCaT cells through enhancing GAB1 expression via sponging miR-194-5p in psoriasis. 2 Circ_0045714 alleviates TNF-alpha-induced chondrocyte injury and extracellular matrix degradation through miR-218-5p/HRAS axis. hsa_circ_0045714 - circ_0045714 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "Up-regulation of circ_0045714 suppressed TNF-¦Á-induced chondrocyte growth inhibition, inflammation, and ECM degradation via miR-218-5p/HRAS axis, suggesting a novel insight into the pathogenesis of OA and the potential protective role of circ_0045714 in the occurrence and development of OA." 4 CircNOL10 suppresses breast cancer progression by sponging miR-767-5p to regulate SOCS2/JAK/STAT signaling. - hsa_circ_NOL10 - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated CircNOL10 repressed BC development via inactivation of JAK2/STAT5 signaling by regulating miR-767-5p/SOCS2 axis. Our findings offer the possibility of exploiting circNOL10 as a therapeutic and prognostic target for BC patients. 4 Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/beta-catenin pathway. hsa_circ_0008259 hsa_circ_LMO7 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircLMO7 promotes the development of GC by releasing the inhibitory effect of miR-30a-3p on its target gene WNT2. 1 Circular RNA RBM33 contributes to cervical cancer progression via modulation of the miR-758-3p/PUM2 axis. - hsa_circ_RBM33 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "CircRBM33 fostered CC advancement via absorbing miR-758-3p and upregulating PUM2, indicating that circRBM33 was a possible target for CC treatment." 1 Silencing of circHIPK3 Inhibits Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction by Sponging miR-185-3p. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:1287 cardiovascular system disease cardiovascular disease "RT-qPCR, RNA-seq" up-regulated circHIPK3 serve as a miR-185-3p sponge to regulate cardiac hypertrophy revealing a potential new target for the prevention of TAC- and Ang-II induced cardiac hypertrophy. 2 CircRNA DNA methyltransferase 1 silence inhibits breast cancer development by regulating micoRNA-485-3p/zinc finger E-box binding homeobox 1 axis. - hsa_circ_DNMT1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ-DNMT1 knockdown constrains breast cancer development via modulating miR-485-3p/ZEB1 axis. 1 Circ_0114876 promoted IL-1beta-induced chondrocyte injury by targeting miR-671/TRAF2 axis. hsa_circ_0114876 - circ_0114876 DOID:8398 osteoarthritis Osteoarthritis RT-qPCR up-regulated "Circ_0114876 targeted miR-671 to regulate cell progression and inflammation via modulating TRAF2 expression in IL-1beta induced CHON-001 cells, and played an important regulatory mechanism in IL-1beta-induced chondrocyte injury, providing a novel diagnostics and therapeutics in OA." 2 Circular RNA hsa_circ_0061395 accelerates hepatocellular carcinoma progression via regulation of the miR-877-5p/PIK3R3 axis. hsa_circ_0061395 - circ_0061395 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0061395 facilitated HCC progression via regulating the miR-877-5p/PIK3R3 axis, providing a new perspective on the advancement of HCC." 4 Circ-CCDC66 upregulates REXO1 expression to aggravate cervical cancer progression via restraining miR-452-5p. - hsa_circ_CCDC66 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Our results demonstrated the role of circ-CCDC66/miR-452-5p/REXO1 axis in cervical cancer progression, we might provide novel therapeutic targets for cervical cancer clinical intervention." 1 Circ_0001175 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis by Regulating miR-130a-5p. hsa_circ_0001175 - circ_0001175 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ_0001175 is highly expressed in HCC and facilitates HCC progression through regulating miR-130a-5p/SNX5 axis. 1 Circular RNA circGSE1 Promotes Cervical Cancer Progression Through miR-138-5p/Vimentin. - hsa_circ_GSE1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated CircGSE1 promotes the progression and may act as a novel diagnostic biomarker for disease progression of cervical cancer. 1 "CircSKA3 Modulates FOXM1 to Facilitate Cell Proliferation, Migration, and Invasion While Confine Apoptosis in Medulloblastoma via miR-383-5p." - hsa_circ_SKA3 - DOID:0050902 medulloblastoma medulloblastoma RT-qPCR up-regulated CircSKA3 augmented MB progression partly through miR-383-5p/FOXM1 axis. 4 Circ_101341 Deteriorates the Progression of Clear Cell Renal Cell Carcinoma Through the miR- 411/EGLN3 Axis. - - circ_101341 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated "Circ_101341 functioned as a tumor promoter to strengthen proliferation, migration and invasion by regulating EGLN3 via sponging miR-411." 1 Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress. - hsa_circ_RSU1 circRSU1 DOID:8398 osteoarthritis Osteoarthritis "RT-qPCR, RNA-seq" up-regulated "We identified a circRSU1-miR-93-5p-MAP3K8 axis that modulates the progression of OA via oxidative stress regulation, which could serve as a potential target for OA therapy." 1 CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression. - hsa_circ_WHSC1 CircWHSC1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated CircWHSC1 played a tumour-promoting role in HCC by elevating HOXA1 through sponging miR-142-3p. 1 Downregulation of circFASTKD1 ameliorates myocardial infarction by promoting angiogenesis. - hsa_circ_FASTKD1 - DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated circFASTKD1 is a potent inhibitor of angiogenesis after myocardial infarction and that silencing circFASTKD1 exerts therapeutic effects during hypoxia by stimulating angiogenesis in vitro and in vivo. 1 Circ-FOXM1 knockdown suppresses non-small cell lung cancer development by regulating the miR-149-5p/ATG5 axis. - hsa_circ_FOXM1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ-FOXM1 knockdown attenuated the development of NSCLC through modulating the miR-149-5p/ATG5 axis, providing a theoretical basis for the therapy of NSCLC." 4 CircRNA PIP5K1A promotes the progression of glioma through upregulation of the TCF12/PI3K/AKT pathway by sponging miR-515-5p. - hsa_circ_PIP5K1A - DOID:0060108 brain glioma glioma RT-qPCR up-regulated CircPIP5K1A is a potential prognostic marker in glioma and regulates glioma evolvement by modulating the miR-515-5p-mediated TCF12/PI3K/AKT axis. 1 Downregulation of circ-TRPS1 suppressed prostatic cancer prognoses by regulating miR-124-3p/EZH2 axis-mediated stemness. - hsa_circ_TRPS1 circ-TRPS1 DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated circ-TRPS1 suppressed PCa progression through functioning similar to a miR-124-3p sponge to enhance EZH2 expression and cancer stem-like cell differentiation. 1 Downregulation of hsa_circ_0026123 suppresses ovarian cancer cell metastasis and proliferation through the miR_124_3p/EZH2 signaling pathway. hsa_circ_0026123 hsa_circ_TUBA1B - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated hsa_circ_0026123 knockdown inhibited OVA cell progression by regulating the miR_124_3p/EZH2 axis. 2 Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR_4428/FUT2 axis. - hsa_circ_CSNK1G1 CSNK1G1 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated circCSNK1G1 promotes the development of OA by targeting the miR_4428/FUT2 axis. 1 circHIPK3 promotes proliferation and migration and invasion via regulation of miR_637/HDAC4 signaling in osteosarcoma cells. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circHIPK3 sponged miR_637 to promote HDAC4 expression and OS cell proliferation, migration and invasion." 4 Hsa_circ_0016760 exacerbates the malignant development of non_small cell lung cancer by sponging miR_145_5p/FGF5. hsa_circ_0016760 hsa_circ_SNAP47 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated hsa_circ_0016760 exacerbated the malignant development of NSCLC by sponging miR_145_5p/FGF5. 6 circ_0044516 functions in the progression of gastric cancer by modulating MicroRNA-149-5p/HuR axis. hsa_circ_0044516 hsa_circ_COL1A1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circ_0044516 may promote HuR expression through sponging miR-149-5p, thereby playing a part in GC progression." 3 Identification of Circular RNA hsa_Circ_0003391 in Peripheral Blood Is Potentially Associated With Alzheimer Disease. hsa_circ_0003391 hsa_circ_UBASH3B - DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated downregulation of hsa_circ_0003391 in the peripheral blood has a potential relationship with AD. 1 Cyclic RNA Circ_0000735 sponges miR-502-5p to promote bladder cancer cell proliferation and invasion and inhibit apoptosis. hsa_circ_0000735 - circ_0000735 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated Circ_0000735 can adsorb miR-502-5p to promote bladder cancer cell proliferation and invasion and inhibit apoptosis. 1 circRNA circARNT2 Suppressed the Sensitivity of Hepatocellular Carcinoma Cells to Cisplatin by Targeting the miR-155-5p/PDK1 Axis. - hsa_circ_ARNT2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated circARNT2 acts as a sponge for miR-155-5p and verified that PDK1 is a novel target of miR-155-5p. 1 CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells. - hsa_circ_MEG3 - DOID:3571 liver cancer liver cancer RT-qPCR up-regulated CircMEG3 inhibits telomerase activity and shortens telomere lifespan dependent on HULC and Cbf5 in human liver cancer stem cell. 1 circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression. - hsa_circ_DCUN1D4 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated circDCUN1D4 suppressed metastasis and glycolysis of lung cancer cells in a TXNIP-dependent manner. 1 CircRNA_000864 Upregulates B-cell Translocation Gene 2 Expression and Represses Migration and Invasion in Pancreatic Cancer Cells by Binding to miR-361-3p. - - circRNA_000864 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated the overexpression of circRNA_000864 could promote BTG2 expression to inhibit pancreatic cancer development by binding to miR-361-3p. 1 CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-alpha in Postmenopausal Osteoporosis. - hsa_circ_Hmbox1 - DOID:11476 osteoporosis postmenopausal osteoporosis RT-qPCR up-regulated circHmbox1-targeting miR-1247-5p is involved in the regulation of bone metabolisms by TNF-alpha in PMOP . 1 CircRNA_25487 inhibits bone repair in trauma-induced osteonecrosis of femoral head by sponging miR-134-3p through p21. - - CircRNA_25487 DOID:10159 osteonecrosis trauma-induced osteonecrosis of femoral head "RT-qPCR, RNA-seq" up-regulated CircRNA_25487 suppression and miR-134-3p overexpression could promote cell proliferation and invasion while inhibited apoptosis of BMSCs and OLCs. miR-134-3p could target p21. CircRNA_25487 inhibited bone repair in TIONFH by sponging miR-134-3p to upregulate the expression of p21. 1 "Circular RNA circ_0068,888 protects against lipopolysaccharide-induced HK-2 cell injury via sponging microRNA-21-5p." hsa_circ_0068888 hsa_circ_WHSC1 - DOID:3021 acute kidney failure acute kidney injury RT-qPCR down-regulated "hsa_circ_0068,888 shows a protective effect on AKI by sponging miR-21-5p. Hence, up-regulation of hsa_circ_0068,888 might be a potential strategy in treatment for AKI." 1 "As a biomarker for gastric cancer, circPTPN22 regulates the progression of gastric cancer through the EMT pathway." - hsa_circ_PTPN22 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated CircPTPN22 can be used as a potential diagnostic and prognostic marker for GC and can inhibit cell proliferation and metastasis through the competitive binding of miRNA to inhibit the EMT pathway. 1 Circular RNA hsa_Circ_0005795 mediates cell proliferation of cutaneous basal cell carcinoma via sponging miR-1231. hsa_circ_0005795 hsa_circ_LPXN - DOID:2513 basal cell carcinoma basal cell carcinoma RT-qPCR up-regulated "Circ_0005795 works as an oncogene in BCC, which might be used as a promising biomarker and a potential therapeutic target for BCC diagnosis and treatment." 2 Circular RNA circZFR Promotes Hepatocellular Carcinoma Progression by Regulating miR-375/HMGA2 Axis. - hsa_circ_ZFR - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Knockdown of circZFR suppressed the progression of HCC by upregulating miR-375 and downregulating HMGA2, providing new insight into the pathogenesis of HCC." 4 Lidocaine Inhibits Hepatocellular Carcinoma Development by Modulating circ_ITCH/miR-421/CPEB3 Axis. - hsa_circ_ITCH "cir-ITCH, circ-ITCH" DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Lidocaine represses hepatocellular carcinoma cell proliferation, migration, and invasion and promotes apoptosis via regulating circ_ITCH/miR-421/CPEB3 axis, indicating a new insight into the mechanism of lidocaine in hepatocellular carcinoma." 5 Circular RNA circ_0081001 knockdown enhances methotrexate sensitivity in osteosarcoma cells by regulating miR-494-3p/TGM2 axis. hsa_circ_0081001 hsa_circ_CYP51A1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "Knockdown of circ_0081001 enhanced MTX sensitivity of OS cells through downregulating TGM2 by sponging miR-494-3p, elucidating a novel regulatory mechanism for chemoresistance of OS and providing a potential circRNA-targeted therapy for OS." 3 Hsa_circ_0123190 acts as a competitive endogenous RNA to regulate APLNR expression by sponging hsa-miR-483-3p in lupus nephritis. hsa_circ_0123190 - - DOID:0080162 lupus nephritis lupus nephritis "RT-qPCR, RNA-seq" down-regulated Hsa_circ_0123190 may function as a ceRNA to regulate APLNR expression by sponging hsa-miR-483-3p in LN. 1 Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway. hsa_circ_0005273 hsa_circ_PTK2 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Hsa_circ_0005273 regulates the miR-200a-3p/YAP1 axis and inactivates Hippo signaling pathway to promote BC progression, which may become a potential biomarker and therapeutic target." 2 circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity. - hsa_circ_NDUFB2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" down-regulated "circNDUFB2 participates in the degradation of IGF2BPs and activation of anti-tumor immunity during NSCLC progression via the modulation of both protein ubiquitination and degradation, as well as cellular immune responses." 1 CircRNA_103765 acts as a proinflammatory factor via sponging miR-30 family in Crohn disease. - - circRNA_103765 DOID:8778 Crohn disease Crohn disease RT-qPCR up-regulated CircRNA_103765 is a novel important regulator of the pathogenesis of IBD via sponging miR-30 family-mediated DLL4 expression changes. Blockade of circRNA_103765 could serve as a novel approach for the treatment of IBD patients. 1 Identification of circ-FAM169A sponges miR-583 involved in the regulation of intervertebral disc degeneration. - hsa_circ_FAM169A circ-FAM169A DOID:90 degenerative disc disease intervertebral disc degeneration RT-qPCR up-regulated circ-FAM169A-miR-583 pathway may regulate NPCs apoptosis and extracellular matrix synthesis and catabolism by targeting Sox9. 2 Astragaloside IV alleviates atherosclerosis through targeting circ_0000231/miR-135a-5p/CLIC4 axis in AS cell model in vitro. hsa_circ_0000231 - circ_0000231 DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated ASV protected HUVECs against ox-LDL-induced injury through targeting circ_0000231/miR-135a-5p/CLIC4 axis. Targeting circ_0000231/miR-135a-5p/CLIC4 axis might provide a novel insight to develop effective strategy for AS treatment. 2 CircRNA hsa_circ_0030018 regulates the development of glioma via regulating the miR-1297/RAB21 axis. hsa_circ_0030018 hsa_circ_POSTN - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "The hsa_circ_0030018 knockdown repressed glioma progression by mediating the miR-1297/RAB21 pathway, providing potential therapeutic targets for glioma treatment." 5 Circ_0006404 Accelerates Prostate Cancer Progression Through Regulating miR-1299/CFL2 Signaling. hsa_circ_0006404 - circ_0006404 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Circ_0006404 accelerated the survival, motility and proliferation while impeded the apoptosis of PCa cells via miR-1299/CFL2 axis. Circ_0006404 might be a stable potential bio-marker for PCa diagnosis and treatment." 1 Circ_0007444 Inhibits the Progression of Ovarian Cancer via Mediating the miR-570-3p/PTEN Axis. hsa_circ_0007444 - circ_0007444 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "circ_0007444 is a tumor suppressor in OC, which inhibits OC progression by mediating the miR-570-3p/PTEN. circ_0007444 can be a potential candidate for targeted therapy of OC." 2 Circular RNA circ_0020123 Promotes Non-Small Cell Lung Cancer Progression Through miR-384/TRIM44 Axis. hsa_circ_0020123 - circ_0020123 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "circ_0020123 knockdown suppressed NSCLC cell progression by regulating the miR-384/TRIM44 axis, providing the theoretical basis for the therapy of NSCLC." 9 AUF1 ligand circPCNX reduces cell proliferation by competing with p21 mRNA to increase p21 production. hsa_circ_0032434 hsa_circ_PCNX - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "we propose that the interaction of circPCNX with AUF1 selectively prevents AUF1 binding to p21 mRNA, leading to enhanced p21 mRNA stability and p21 protein production, thereby suppressing cell growth." 1 Knockdown of cir_RNA PVT1 Elevates Gastric Cancer Cisplatin Sensitivity via Sponging miR-152-3p. - hsa_circ_PVT1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "CircPVT1 regulated the chemoresistance and malignancy of GC through modulating HDGF expression via sponging miR-152-3p, providing a theoretical basis for the development of effective therapeutic strategies for GC." 6 Reduced expression of circRNA novel_circ_0005280 and its clinical value in the diagnosis of non-small cell lung cancer. hsa_circ_0005280 - novel_circ_0005280 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" up-regulated Novel_circ_0005280 may be a useful biomarker for the diagnosis and prognosis of NSCLC. 1 The decreased expression of hsa_circ_0043278 and its relationship with clinicopathological features of breast cancer. hsa_circ_0043278 hsa_circ_TADA2A - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated hsa_circ_0043278 is downregulated and may play a key role in human breast cancer. 4 Circ_0004104 Accelerates the Progression of Gastric Cancer by Regulating the miR-539-3p/RNF2 Axis. hsa_circ_0004104 hsa_circ_SPARC - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Circ_0004104 accelerated GC progression via regulating the miR-539-3p/RNF2 axis, indicating that circ_0004104 might be a potential therapeutic target for GC." 1 Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric Cancer via miR-409-3p/MAP7 Axis. - hsa_circ_NEK9 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "CircNEK9 accelerated the proliferation, migration, and invasion of GC cells through targeting miR-409-3p/MAP7 axis. Plasma exosomal circNEK9 promoted the migration and invasion of recipient GC cells." 1 Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis. hsa_circ_0003353 - - DOID:848 arthritis arthritis RT-qPCR up-regulated "Our results indicate that hsa_circ_0003353 may play an essential role in promoting immunity, inflammation, synovial invasion, and joint destruction and that hsa_circ_0003353 may act as a biomarker of RA." 1 CircPVT1 promotes progression in clear cell renal cell carcinoma by sponging miR-145-5p and regulating TBX15 expression. - hsa_circ_PVT1 - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, RNA-seq" up-regulated circPVT1 promotes ccRCC growth and metastasis through sponging miR-145-5p and regulating downstream target TBX15 expression. The circPVT1/miR-145-5p/TBX15 axis might be a potential diagnostic marker and therapeutic target in ccRCC. 1 Circ_SMAD4 promotes gastric carcinogenesis by activating wnt/beta-catenin pathway. - hsa_circ_SMAD4 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated "Circ_SMAD4 facilitated GC tumorigenesis by activating CTNNB1-dependent Wnt/beta-catenin pathway. Hopefully, the findings could provide new clues for improving GC prognosis and treatment." 1 FUS-induced circular RNA ZNF609 promotes tumorigenesis and progression via sponging miR-142-3p in lung cancer. - hsa_circ_ZNF609 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated FUS-induced circZNF609 exerts promotional effects on LC cell proliferation and migration through modulation of the miR-142-3p/GNB2 axis. 2 Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis. - hsa_circ_SDHC - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated "Our data indicates, for the first time, an essential role for the circSDHC/miR-127-3p/CDKN3/E2F1 axis in RCC progression. Thus, circSDHC has potential to be a new therapeutic target in patients with RCC." 1 Knockdown of circ-FANCA alleviates LPS-induced HK2 cell injury via targeting miR-93-5p/OXSR1 axis in septic acute kidney injury. - hsa_circ_FANCA - DOID:0040085 bacterial sepsis sepsis RT-qPCR up-regulated Circ-FANCA knockdown attenuated LPS-induced HK2 cell injury by regulating OXSR1 expression via targeting miR-93-5p. 1 Up-Regulation of circEIF6 Contributes to Pancreatic Cancer Development Through Targeting miR-557/SLC7A11/PI3K/AKT Signaling. - hsa_circ_EIF6 - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "CircEIF6 aggravated pancreatic cancer development through promoting cell proliferation, migration and invasion and suppressing cell apoptosis through targeting miR-557/SLC7A11/PI3K/AKT signaling." 1 Circular RNA hsa_circ_0000554 promotes progression and elevates radioresistance through the miR-485-5p/fermitin family members 1 axis in esophageal cancer. hsa_circ_0000554 hsa_circ_LIN52 - DOID:5041 esophageal cancer esophageal cancer RT-qPCR down-regulated "FERMT1 enhancement reversed circ_0000554 inhibition-mediated effects on the colony formation, migration, invasion, radiosensitivity and apoptosis of esophageal cancer cells. Circ_0000554 silencing repressed EC progression and enhanced cell radiosensitivity through downregulating FERMT1 via sponging miR-485-5p, which provided a possible method for improving the radioresistence of esophageal cancer." 1 Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis. - hsa_circ_PUM1 CircPUM1 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated "CircPUM1 upregulates FABP7 expression by competitively binding to miR-340-5p, and then activates the MEK/ERK pathway, thus promoting ccRCC progression." 1 Circular RNA circ_0008274 enhances the malignant progression of papillary thyroid carcinoma via modulating solute carrier family 7 member 11 by sponging miR-154-3p. hsa_circ_0008274 - circ_0008274 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "the knockdown of circ_0008274 repressed PTC malignant progression at least in part through regulating the miR-154-3p/SLC7A11 axis, providing a promising therapeutic opportunity for PTC treatment." 2 Hsa_circ_0001073 targets miR-626/LIFR axis to inhibit lung cancer progression. hsa_circ_0001073 hsa_circ_ACVR2A - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "circ_0001073 represses lung cancer progression via miR-626/LIFR axis, indicating the potential value of circ_0001073 in lung cancer treatment." 2 Circular RNA circRUNX1 promotes papillary thyroid cancer progression and metastasis by sponging MiR-296-3p and regulating DDHD2 expression. - hsa_circ_RUNX1 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "The strong antitumor effect of miR-296-3p and the tumor-promoting effect of DDHD2 were further investigated in PTC, indicating that circRUNX1 modulates PTC progression through the miR-296-3p/DDHD2 pathway. Overall, circRUNX1 plays an oncogenic role in PTC and provides a potentially effective therapeutic strategy for PTC progression." 1 Circular RNA circNINL promotes breast cancer progression through activating beta-catenin signaling via miR-921/ADAM9 axis. - hsa_circ_NINL - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "we demonstrated that circNINL could interact with miR-921 and facilitate BC cells malignant process including proliferation acceleration, migration enhancement and apoptosis evasion via sponging miR-921 in vitro. Further investigations revealed that circNINL/miR-921 axis could mediate the expression of ADAM9 which was a direct target of miR-921." 1 circGFRA1 affects the sensitivity of triple-negative breast cancer cells to paclitaxel via the miR-361-5p/TLR4 pathway. - hsa_circ_GFRA1 - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "circGFRA1 knockdown can inhibit the resistance of TNBC cells to PTX by promoting the expression of miR-361-5p, and subsequently reduce the expression of TLR4." 3 CircCAMSAP1 promotes hepatocellular carcinoma progression through miR-1294/GRAMD1A pathway. - hsa_circ_CAMSAP1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "CircCAMSAP1 was up-regulated in HCC tissues, and circCAMSAP1 up-regulated GRAMD1A expression to promote HCC proliferation, migration and invasion through miR-1294. CircCAMSAP1 might be a potential prognosis and therapeutic target for HCC." 1 Silencing circ-USP1 protects the renal tubular from kidney injury induced by hypoxia via modulating miR-194-5p/DNMT3A axis in acute renal allografts. - mmu_circ_USP1 - DOID:557 kidney disease kidney injury RT-qPCR up-regulated silencing circ-USP1 reduced DNMT3A expression in the kidney of mice that received renal allografts. Circ-USP1 functions as a competing endogenous RNA for miR-194-5p. This occurs in order to regulate DNMT3A expression in kidney injury induced by hypoxia in acute renal allografts. 1 Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma. hsa_circ_0006571 hsa_circ_SATB2 - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated Hsa_circ_0006571 promoted tumor cell migration and invasion via the miR-138/Sirt1 pathway. 2 CircRNAs Dysregulated in Juvenile Myelomonocytic Leukemia: CircMCTP1 Stands Out. - hsa_circ_MCTP1 - DOID:0050458 juvenile myelomonocytic leukemia juvenile myelomonocytic leukemia RT-qPCR up-regulated "In conclusion, this study provides insight into the circRNAome of JMML and paves the path to elucidate new molecular disease mechanisms putting forward circMCTP1 up-regulation as a robust example." 1 "Circular RNA CircNOLC1, Upregulated by NF-KappaB, Promotes the Progression of Prostate Cancer via miR-647/PAQR4 Axis." - hsa_circ_NOLC1 - DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated "CircNOLC1, elevated by transcription factor NF-kappaB, promotes PCa progression via a miR-647/PAQR4 axis, and circNOLC1 is a potential biomarker and target for PCa treatment." 1 Hsa_circ_0010235 functions as an oncogenic drive in non-small cell lung cancer by modulating miR-433-3p/TIPRL axis. hsa_circ_0010235 hsa_circ_ALDH4A1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Hsa_circ_0010235 knockdown suppressed NSCLC progression by regulating miR-433-3p/TIPRL axis, affording a novel mechanism of NSCLC progression." 4 Circular RNA 0081146 facilitates the progression of gastric cancer by sponging miR-144 and up-regulating HMGB1. hsa_circ_0081146 - Circ_0081146 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Circ_0081146 functions as an oncogene in GC to promote cell growth, migration and invasion via modulating the miR-144/HMGB1 axis." 1 Circular RNA ITCH suppresses metastasis of gastric cancer via regulating miR-199a-5p/Klotho axis. - hsa_circ_ITCH circ-ITCH DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "circ-ITCH suppresses metastasis of GC by acting as the sponge of miR-199a-5p and increasing Klotho expression, which serves as a potential biomarker and targets for the diagnosis and therapy of GC." 3 Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1. - hsa_circ_FLNA - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "circFLNA acted as a sponge of miR-486-3p to promote the proliferation, migration, and invasion of lung cancer cells in vitro and in vivo by regulating XRCC1 and CYP1A1." 1 CircSKA3 Downregulates miR-1 Through Methylation in Glioblastoma to Promote Cancer Cell Proliferation. - hsa_circ_SKA3 - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated circSKA3 may downregulate miR-1 through methylation in GBM to promote cancer cell proliferation. 1 circRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene. - - CircRNA_141539 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, microarray" up-regulated circRNA_141539 served as an oncogenic factor in ESCC by sponging miR-4469 and activating CDK3 expression. circRNA_141539 may present as a novel diagnostic and prognostic biomarker and a therapeutic target for patients with ESCC. 1 circRNA circ_102049 Implicates in Pancreatic Ductal Adenocarcinoma Progression through Activating CD80 by Targeting miR-455-3p. - - circRNA_102049 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated "Our findings showed that circRNA_102049 and methylated hub genes play an important role in the proliferation, apoptosis, migration, invasion, and inflammatory response of PDAC, which might be selected as a promising prognostic marker and therapeutic target for PDAC." 1 Propofol suppresses lung cancer tumorigenesis by modulating the circ-ERBB2/miR-7-5p/FOXM1 axis. - hsa_circ_ERBB2 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "Propofol inhibited lung cancer progression via mediating circ-ERBB2/miR-7-5p/FOXM1 axis, which might provide an effective therapeutic target for lung cancer therapy." 2 Circular RNA CircMTO1 suppressed proliferation and metastasis of osteosarcoma through miR-630/KLF6 axis. - hsa_circ_MTO1 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" down-regulated "circMTO1 could suppress osteosarcoma progression by regulating miR-630/KLF6 axis, which may highlight the diagnostic and therapeutic potential of these molecules in osteosarcoma treatment." 2 Upregulated circRNA hsa_circ_0071036 promotes tumourigenesis of pancreatic cancer by sponging miR-489 and predicts unfavorable characteristics and prognosis. hsa_circ_0071036 hsa_circ_INPP4B - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "upregulated hsa_circ_0071036 promotes PDAC pathogenesis and progression by directly sponging miR-489, which implies an important role for this circRNA-miRNA functional network." 1 Circular RNA hsa_circ_0004277 Stimulates Malignant Phenotype of Hepatocellular Carcinoma and Epithelial-Mesenchymal Transition of Peripheral Cells. hsa_circ_0004277 hsa_circ_WDR37 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated exosomal circ-0004277 from HCC cells stimulates EMT of peripheral cells through cellular communication to further promote the invasion of HCC into normal surrounding tissues. 2 Circ_0003998 Regulates the Progression and Docetaxel Sensitivity of DTX-Resistant Non-Small Cell Lung Cancer Cells by the miR-136-5p/CORO1C Axis. hsa_circ_0003998 - Circ_0003998 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our present work identified that circ_0003998 regulated DTX-resistant NSCLC cell colony formation, apoptosis and DTX sensitivity at least partially by controlling CORO1C expression by sponging miR-136-5p, illuminating a rationale for developing circ_0003998 as a therapeutic target of chemoresistant NSCLC." 2 The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex. hsa_circ_0072088 hsa_circ_ZFR - DOID:4362 cervical cancer cervical cancer "RT-qPCR, microarray" up-regulated "circZFR bound with SSBP1, thereby promoting the assembly of CDK2/cyclin E1 complexes. The activation of CDK2/cyclin E1 complexes induced p-Rb phosphorylation, thus releasing activated E2F1 leading to cell cycle progression and cell proliferation. " 2 Circular RNA AKT3 governs malignant behaviors of esophageal cancer cells by sponging miR-17-5p. - hsa_circ_AKT3 - DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated CircAKT3 contributed to the malignant behaviors of esophageal cancer in vitro and in vivo by sponging miR-17-5p thus providing a potential target for treatment of esophageal cancer. 1 Circular RNA circPHC3 Promotes Cell Death and Apoptosis in Human BMECs After Oxygen Glucose Deprivation via miR-455-5p/TRAF3 Axis in vitro. hsa_circ_0001360 hsa_circ_PHC3 - DOID:6713 cerebrovascular disease ischemic stroke "RT-qPCR, RNA-seq" up-regulated "circPHC3 promotes cell death and apoptosis in ischemic stroke in vitro model, which might be a novel molecular target for acute cerebrovascular protection." 2 Circular RNA circSEC24A Promotes Cutaneous Squamous Cell Carcinoma Progression by Regulating miR-1193/MAP3K9 Axis. - hsa_circ_SEC24A - DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma RT-qPCR up-regulated "CircSEC24A interference suppressed the progression of CSCC by regulating miR-1193/MAP3K9 axis, which might be a promising strategy for CSCC treatment." 1 A circGLIS3/miR-644a/PTBP1 positive feedback loop promotes the malignant biological progressions of non-small cell lung cancer. - hsa_circ_GLIS3 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircGLIS3 functions as an oncogene via sponging multiple tumor-suppressive miRNAs in NSCLC. A circGLIS3/miR-644a/PTBP1 positive feedback loop exists in the tumorigenesis and development of NSCLC. 1 CircularRNA circPARP4 promotes glioblastoma progression through sponging miR-125a-5p and regulating FUT4. - hsa_circ_PARP4 - DOID:0060108 brain glioma glioma "RT-qPCR, microarray" up-regulated "Our findings illustrate functions of circPARP4 in modulating glioma progression through miR-125a-5p/FUT4 pathway, which provides a novel and potential target for glioma therapy." 2 Circ0083429 Regulates Osteoarthritis Progression via the Mir-346/SMAD3 Axis. hsa_circ_0083429 - circ0083429 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Circ0083429 regulates the ECM via the regulation of the downstream miRNA-346/SMAD3 in human chondrocytes. 1 Hsa_circ_0020095 Promotes Oncogenesis and Cisplatin Resistance in Colon Cancer by Sponging miR-487a-3p and Modulating SOX9. hsa_circ_0020095 hsa_circ_ATRNL1 - DOID:219 colon cancer colon cancer RT-qPCR up-regulated "Circ_0020095 functions as an oncogene to accelerate CC cell proliferation, invasion, migration and cisplatin resistance through the miR-487a-3p/SOX9 axis." 1 Identification of circ_0089153/miR-608/EGFR p53 axis in ameloblastoma via MAPK signaling pathway. hsa_circ_0089153 - circ_0089153 DOID:0050894 ameloblastoma ameloblastoma "RT-qPCR, microarray" up-regulated "Six novel circRNAs were identified. Hsa_circ_0089153/hsa-miR-608 sponging was validated, hsa-miR-608 downregulated EGFR and p53, which might further regulate cell proliferation, differentiation, apoptosis, and cell cycle processes via the MAPK signaling pathway." 1 Circ_0081572 inhibits the progression of periodontitis through regulating the miR-378h/RORA axis. hsa_circ_0081572 - circ_0081572 DOID:824 periodontitis periodontitis RT-qPCR down-regulated Our results suggested that circ_0081572 might prevent periodontitis by regulating the miR-378h /RORA axis 1 "CircTM7SF3 contributes to oxidized low-density lipoprotein-induced apoptosis, inflammation and oxidative stress through targeting miR-206/ASPH axis in atherosclerosis cell model in vitro." - hsa_circ_TM7SF3 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated CircTM7SF3 contributed to ox-LDL-induced injury in AS cell model through up-regulating the expression of ASPH via targeting miR-206. 2 CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer. hsa_circ_0071127 hsa_circ_NR3C2 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq, microarray" down-regulated "we elucidated a bona fide circNR3C2/miR-513a-3p/HRD1/Vimentin axis that negatively regulates the metastasis of TNBC, suggesting that circNR3C2 and HRD1 can act as potential prognostic biomarkers. Our study may facilitate the development of therapeutic agents targeting circNR3C2 and HRD1 for patients with aggressive breast cancer." 1 Circular RNA hsa_circ_0009172 suppresses gastric cancer by regulation of microRNA-485-3p-mediated NTRK3. hsa_circ_0009172 hsa_circ_DNA2 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Functionally, hsa_circ_0009172 overexpression inhibited proliferative, invasive and migrative potential of gastric cancer cells as well as epithelial-mesenchymal transition (EMT)-related proteins by sponging miR-485-3p to inhibit NTRK3, while miR-485-3p overexpression could reverse the inhibitory effect of hsa_circ_0009172 on gastric cancer." 2 Circ_0035483 Functions as a Tumor Promoter in Renal Cell Carcinoma via the miR-31-5p-Mediated HMGA1 Upregulation. hsa_circ_0035483 - Circ_0035483 DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated These findings clarified that the tumor-promoting function of circ_0035483 in RCC was partly achieved by regulating the miR-31-5p/HMGA1 axis. 2 Circ_0031242 Silencing Mitigates the Progression and Drug Resistance in DDP-Resistant Hepatoma Cells by the miR-924/POU3F2 Axis. hsa_circ_0031242 - Circ_0031242 DOID:684 hepatocellular carcinoma hepatoma RT-qPCR up-regulated "circ_0031242 functioned as an important regulator in DDP-resistant HCC cell progression and DDP resistance through the miR-924/POU3F2 axis, illuminating circ_0031242 as a potential therapeutic target for the chemoresistant HCC." 3 Circular RNA circEPSTI1 accelerates cervical cancer progression via miR-375/409-3P/515-5p-SLC7A11 axis. - hsa_circ_EPSTI1 hsa_circRNA_000479 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated our results revealed that circRNAs may also play very important roles in cervical cancer acting as miRNA sponges. We found that circEPSTI1-miR-375/409-3P/515-5p-SLC7A11 axis promotes the cervical cancer cell proliferation through a mechanism involving ceRNA. 2 Circ_AFF2 facilitates proliferation and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-375/TAB2 axis. - hsa_circ_AFF2 circ_AFF2 DOID:848 arthritis arthritis RT-qPCR up-regulated "These findings clarified that circ_AFF2 induced cell progression, inflammatory response in FLS-RA cells via the miR-375/TAB2 axis. Circ_AFF2 could be used as a biomarker in the diagnosis and treatment of RA." 1 Hsa_circ_0025202 suppresses cell tumorigenesis and tamoxifen resistance via miR-197-3p/HIPK3 axis in breast cancer. hsa_circ_0025202 hsa_circ_GAPDH - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "Hsa_circ_0025202 repressed cell tumorigenesis and TAM resistance via miR-197-3p/HIPK3 axis in BC, suggesting a potential therapeutic strategy to overcome chemoresistance in BC patients." 2 Circ_TOP2A acts as a ceRNA for miR_346 and contributes to glioma progression via the modulation of sushi domain_containing 2. - hsa_circ_TOP2A - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circ_TOP2A promoted GM proliferation and aggressiveness via miR_346/SUSD2 signaling, which is a potential prognostic biomarker and therapeutic target for GM." 2 CircRNA_0000429 Regulates Development of NSCLC by Acting as a Sponge of miR-1197 to Control MADD. hsa_circ_0000429 - CircRNA_0000429 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ_0000429 exhibited a carcinogenic role by sponging miR-1197 and regulating CMADD expression in NSCLC. These findings provided evidence for understanding the role of circ_0000429 in NSCLC tumorigenesis. 1 circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFbetaR1/VEGF-D signaling. - hsa_circ_EHBP1 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated "the circEHBP1/miR-130a-3p/TGFbetaR1/VEGF-D axis contributes to lymphangiogenesis and lymphatic metastasis of bladder cancer independent of VEGF-C, which might lead to the development of circEHBP1 as a potential biomarker and promising therapeutic target for lymphatic metastasis in bladder cancer." 1 Hsa_circ_0001696 modulates cell proliferation and migration in colorectal cancer. hsa_circ_0001696 hsa_circ_HERPUD2 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "hsa_circ_0001696 expression was downregulated in CRC tissues, and inhibition of hsa_circ_0001696 promoted cell proliferation and migration by regulating the levels of CDK4, cyclin D, cyclin E and MMP9." 1 Circular RNA circANKIB1 promotes the progression of osteosarcoma by regulating miR-217/PAX3 axis. - hsa_circ_ANKIB1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Knockdown of circANKIB1 suppressed OS progression by upregulating miR-217 and downregulating PAX3, which might provide a novel insight into the pathogenesis of OS." 3 Down-regulation of circular RNA hsa_circ_0007534 suppresses cell growth by regulating miR-219a-5p/SOX5 axis in osteosarcoma. hsa_circ_0007534 hsa_circ_DDX42 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "circ_0007534 knockdown suppressed the growth of OS cells via regulating miR-219a-5p/SOX5 axis, providing a potential target for OS treatment and diagnosis." 2 "circ_NOTCH3 Functions as a Protooncogene Competing With miR-205-5p, Modulating KLF12 Expression and Promoting the Development and Progression of Basal-Like Breast Carcinoma." hsa_circ_0109177 hsa_circ_NOTCH3 - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated "circ_NOTCH3, being an protooncogene and a powerful biomarker, can function as a sponge, compete with miR-205-5p, modulate KLF12 expression, and promote the development and progression of BLBC." 1 Circular RNA circANKS1B acts as a sponge for miR-152-3p and promotes prostate cancer progression by upregulating TGF-alpha expression. - hsa_circ_ANKS1B - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Knockdown of circANKS1B markedly suppressed cell migration and invasion and TGF-alpha expression in PC cells, whereas the effects of circANKS1B silencing were reversed by miR-152-3p deficiency. In addition, the impact of miR-152-3p silencing on invasion of circANKS1B-deficient PC cells was also abrogated by TGF-alpha deficiency. Overall, circANKS1B acts as a sponge for miR-152-3p to promote PC progression by upregulating TGF-alpha expression." 1 "Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis." hsa_circ_0000735 hsa_circ_P2RX1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "Circ_0000735 promoted NSCLC progression by the miR-635/FAM83F axis, showing that circ_0000735 might be a promising biomarker for NSCLC. Highlights: Circ_0000735 knockdown represses NSCLC cell progression and tumor growth. Circ_0000735 functions as a miR-635 sponge. FAM83F is targeted by miR-635." 4 Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis. - hsa_circ_HECTD1 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "this study investigated a novel biomarker panel consisting of the circHECTD1/miR-296-3p/SLC10A7 axis, which is critical for glioma tumorigenesis and invasiveness and may represent a novel therapeutic target for intervening in glioma progression." 1 Repression of circRNA_000684 inhibits malignant phenotypes of pancreatic ductal adenocarcinoma cells via miR-145-mediated KLF5. - - circRNA_000684 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR down-regulated "CircRNA_000684 negatively regulated miR-145 expression, while miR-145 negatively regulated KLF5. In-vivo, circRNA_000684 elevation or miR-145 repression promoted tumor growth." 1 circST6GALNAC6 suppresses bladder cancer metastasis by sponging miR-200a-3p to modulate the STMN1/EMT axis. hsa_circ_0088708 hsa_circ_ST6GALNAC6 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" down-regulated "Thus, our findings indicate an important underlying mechanism in BCa metastasis by which SP1-induced circST6GALNAC6 sponges miR-200a-3p to promote STMN1/EMT signalling. This mechanism could provide pivotal potential prognostic biomarkers and therapeutic targets for BCa." 2 Circ-AASDH functions as the progression of early stage lung adenocarcinoma by targeting miR-140-3p to activate E2F7 expression. - hsa_circ_AASDH Circ-AASDH DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Circ-AASDH/miR-140-3p/E2F7 regulating axis promoted the progression in LUAD. Our results provided ideas for understanding the biological mechanism of circ-AASDH and clarify potential therapeutic targets in LUAD. 1 M6A modification of circNSUN2 promotes colorectal liver metastasis. - hsa_circ_NSUN2 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "These discoveries not only expand our understanding of circRNAs biology in tumor, but also demonstrate that m6A modification plays a key role for circRNAs in RNA metabolism. Therefore, these findings indicate that circRNAs may be a new approach for therapeutic target of cancers." 3 Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis. - hsa_circ_PIP5K1A circ_PIP5K1A DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ_PIP5K1A positively regulated ABCC1 expression by sponging miR-101. Exosomal circ_PIP5K1A knockdown inhibited NSCLC progression and promoted cisplatin sensitivity by regulating miR-101/ABCC1 axis, providing a novel avenue for treatment of NSCLC." 4 CircRNA ZNF609 Knockdown Represses the Development of Non-Small Cell Lung Cancer via miR-623/FOXM1 Axis. - hsa_circ_ZNF609 CircRNA ZNF609 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circZNF609 knockdown repressed NSCLC development via regulating miR-623 and FOXM1. 1 CircUSP36 knockdown alleviates oxidized low_density lipoprotein_induced cell injury and inflammatory responses in human umbilical vein endothelial cells via the miR_20a_5p/ROCK2 axis. - hsa_circ_USP36 - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "circUSP36 targeted miR_20a_5p to regulate the expression of ROCK2. On the whole, the present study demonstrates that, circUSP36 regulates ox_LDL_induced HUVEC injury and inflammation by modulating ROCK2 via competitively targeting miR_20a_5p." 7 Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways. hsa_circ_0119872 - Circ_0119872 DOID:6039 uveal melanoma uveal melanoma RT-qPCR up-regulated "Circ_0119872 may act as an oncogene in UM through a novel circ_0119872/miR-622/G3BP1 axis, activating the Wnt/beta-catenin and mTOR signalling pathways, which in turn may provide potential biomarkers and therapeutic targets for the management of UM." 1 Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction. - mmu_circ_TTC3 - DOID:2316 brain ischemia cerebral ischemia RT-qPCR up-regulated "Thus, we conclude that circTTC3 regulates CIR injury and NSCs by the miR-372-3p/TLR4 axis in cerebral infarction. Our finding presents new insight into the mechanism by which circTTC3 modulates CIR injury and NSC dysfunction. CircTTC3, miR-372-3p, and TLR4 may serve as potential targets for the treatment of CIR injury during stroke." 1 Circular RNA circARPP21 Acts as a Sponge of miR-543 to Suppress Hepatocellular Carcinoma by Regulating LIFR. hsa_circ_0123629 hsa_circ_ARPP21 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "The circARPP21/miR-543/LIFR axis suppresses the proliferation, invasion, and migration of hepatocellular carcinoma cells. In addition, circARPP21 can serve as a biomarker in HCC, thus offering a potential new approach to HCC therapy." 1 Hsa_circ_0107593 Suppresses the Progression of Cervical Cancer via Sponging hsa-miR-20a-5p/93-5p/106b-5p. hsa_circ_0107593 hsa_circ_ABCA5 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "hsa_circ_0107593 has tumor-suppressing activity in CC by physically binding with hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p." 1 The novel circular RNA circ-PGAP3 retards cervical cancer growth by regulating the miR-769-5p/p53 axis. - hsa_circ_PGAP3 circ-PGAP3 DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated "our data clearly expounded the tumor-inhibiting role of circ-PGAP3 in CC, circ-PGAP3 repressed CC tumorigenesis via regulating the miR-769-5p/p53 axis. Therefore, restoration of circ-PGAP3 may be a promising therapeutic target for this thorny disease." 1 Circ_ 0115744 acts as miR-144 sponge to promote and predict the metastasis of colorectal cancer. hsa_circ_0115744 - circ_0115744 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "we found that increased expression of circ_0115744 could differentiate CRLM from CRC and that the newly identified circ_0115744/miR-144/EZH2 axis was involved in the progression of CRC, which might be used as a potential diagnostic and therapeutic target for patients with CRC." 1 "Circ_0004872 promotes platelet-derived growth factor-BB-induced proliferation, migration and dedifferentiation in HA-VSMCs via miR-513a-5p/TXNIP axis." hsa_circ_0004872 - Circ_0004872 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "TXNIP was modulated by circ_0004872/miR-513a-5p signaling cascade in HA-VSMCs. Circ_0004872 accelerated PDGF-BB-induced proliferation, migration and dedifferentiation in HA-VSMCs through enhancing TXNIP level via sponging miR-513a-5p." 1 Circular RNA CDR1as promotes tumor progression by regulating miR-432-5p/E2F3 axis in pancreatic cancer. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated circCDR1as could promote the development of PC and might be a novel diagnostic target for PC. 1 Circular RNA circ_0014717 Suppresses Hepatocellular Carcinoma Tumorigenesis Through Regulating miR-668-3p/BTG2 Axis. hsa_circ_0014717 hsa_circ_CCT3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ_0014717 Suppresses Hepatocellular Carcinoma Tumorigenesis Through Regulating miR-668-3p/BTG2 Axis. 3 Effects of circular RNA Ttc3/miR-148a/Rcan2 axis on inflammation and oxidative stress in rats with acute kidney injury induced by sepsis. - hsa_circ_Ttc3 circular RNA Ttc3 DOID:557 kidney disease kidney injury RT-qPCR down-regulated "CIRC-Ttc3 relieved inflammation and oxidative stress through regulating the miR-148a/Rcan2 axis in rats with AKI induced by sepsis. Therefore, CIRC-Ttc3 may be a potential therapeutic target for sepsis-induced AKI." 1 CircRNA circYY1 (hsa_circ_0101187) Modulates Cell Glycolysis and Malignancy Through Regulating YY1 Expression by Sponging miR-769-3p in Breast Cancer. hsa_circ_0101187 hsa_circ_YY1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "CircYY1 promoted glycolysis and tumor growth via increasing YY1 expression through sponging miR-769-3p in BC, offering a promising therapeutic target and prognostic biomarker for BC." 1 "Circ_0056285 Regulates Proliferation, Apoptosis and Glycolysis of Osteosarcoma Cells via miR-1244/TRIM44 Axis." hsa_circ_0056285 - Circ_0056285 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ_0056285 facilitated OS progression by sponging miR-1244 and increasing TRIM44 expression, providing a promising therapeutic target for OS." 1 "CircGDI2 Regulates the Proliferation, Migration, Invasion and Apoptosis of OSCC via miR-454-3p/FOXF2 Axis." - hsa_circ_GDI2 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "CircGDI2 served as a repressor to restrain OSCC malignancy via miR-454-3p/FOXF2 axis, which might be a novel biomarker for targeted OSCC therapy." 2 Circ_0065149 Alleviates Oxidized Low-Density Lipoprotein-Induced Apoptosis and Inflammation in Atherosclerosis by Targeting miR-330-5p. hsa_circ_0065149 - circ_0065149 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "These findings suggest that circ_0065149 plays an important role in the proliferation, apoptosis, and inflammatory response of HUVECs via targeting miR-330-5p." 1 circFOXM1 contributes to sorafenib resistance of hepatocellular carcinoma cells by regulating MECP2 via miR-1324. - hsa_circ_FOXM1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated miR-1324 overexpression was capable of reversing the circFOXM1-induced malignant phenotypes and elevated expression of MECP2 in HCC cells. circFOXM1 partially contributed to sorafenib resistance of HCC cells through upregulating MECP2 expression by sponging miR-1324. 2 Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p/Smad7 axis. - hsa_circ_PSD3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq down-regulated "our present findings reveal a novel mechanism by which circPSD3 alleviates hepatic fibrogenesis by targeting the miR-92b-3p/Smad7 axis, and they also indicate that circPSD3 may serve as a potential biomarker for HF." 1 Circular RNA RBPMS inhibits bladder cancer progression via miR-330-3p/RAI2 regulation. - hsa_circ_RBPMS - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "We summarize the circRBPMS/miR-330-3p/RAI2 axis, where circRBPMS acts as a tumor suppressor, and provide a potential biomarker and therapeutic target for BC." 1 "hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension." - hsa_circ_NFXL1_009 - DOID:6432 pulmonary hypertension pulmonary hypertension "RT-qPCR, RNA-seq" up-regulated "hsa_circNFXL1_009 as a key regulator of PAH, and it may be used as a potential therapeutic target for the treatment of PAH." 1 Hsa_circ_0102171 aggravates the progression of cervical cancer through targeting miR-4465/CREBRF axis. hsa_circ_0102171 hsa_circ_KTN1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circ_0102171 aggravates CC progression via targeting miR-4465/CREBRF axis. 1 Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR-218. - mmu_circ_EIF4G2 - DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated circEIF4G2 promotes renal tubular epithelial cell fibrosis via the miR-218/SERBP1 pathway. 1 CircAGAP1 promotes tumor progression by sponging miR-15-5p in clear cell renal cell carcinoma. - hsa_circ_AGAP1 circ0058792 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, microarray" up-regulated "Our results clarify that circAGAP1 exerts its oncogenic functions as a competitive endogenous RNA (ceRNA) by sponging miR-15-5p, which promotes E2F3 expression. Targeting circAGAP1 might be a new attractive therapeutic strategy in ccRCC." 1 CircVAPA exerts oncogenic property in non-small cell lung cancer by the miR-876-5p/WNT5A axis. - hsa_circ_VAPA - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircVAPA promotes aggressive phenotypes of NSCLC cells by the miR-876-5p/WNT5A axis activating Wnt/beta-catenin signaling. 2 Circular RNA circ_0002137 regulated the progression of osteosarcoma through regulating miR-433-3p/ IGF1R axis. hsa_circ_0002137 hsa_circ_CNIH3 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "circ_0002137 could restrain the progression of OS through regulating miR-433-3p/IGF1R axis, providing a comprehensive landscape of circ_0002137 in the generation and development of OS." 1 Inhibition of hsa_circ_0003489 shifts balance from autophagy to apoptosis and sensitizes multiple myeloma cells to bortezomib via miR-874-3p/HDAC1 axis. hsa_circ_0003489 hsa_circ_CDK8 - DOID:9538 multiple myeloma multiple myeloma RT-qPCR down-regulated The hsa_circ_0003489/miR-874-3p/HDAC1 axis critically regulates the balance between apoptosis and autophagy. Silencing hsa_circ_0003489 sensitizes MM cells to BTZ by inhibiting autophagy and thus may boost the therapeutic effects of BTZ. 2 Circular RNA circDNM3OS Functions as a miR-145-5p Sponge to Accelerate Cholangiocarcinoma Growth and Glutamine Metabolism by Upregulating MORC2. - hsa_circ_DNM3OS - DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR up-regulated "CircDNM3OS facilitates CCA growth and glutamine metabolism by regulating the miR-145-5p/MORC2 pathway, offering a novel mechanism to understand the progression of CCA." 2 Circ_0006174 Accelerates Colorectal Cancer Progression Through Regulating miR-138-5p/MACC1 Axis. hsa_circ_0006174 - circ_0006174 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0006174 advanced CRC progression via sponging miR-138-5p to upregulate MACC1 expression, which may provide a promising molecular target for CRC treatment." 5 Circ_0000527 Promotes Retinoblastoma Progression through Modulating miR-98-5p/XIAP Pathway. hsa_circ_0000527 - Circ_0000527 DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated "Circ_0000527 facilitated RB progression via regulating miR-98-5p/XIAP axis, which provided a promising therapeutic target for RB." 5 "Circ_0006948 Contributes to Cell Growth, Migration, Invasion and Epithelial-Mesenchymal Transition in Esophageal Carcinoma." hsa_circ_0006948 - circ_0006948 DOID:1107 esophageal carcinoma esophageal carcinoma RT-qPCR up-regulated circ_0006948 functioned as an oncogenic factor in EC by the miR-4262-mediated FNDC3B expression regulation. 1 "CircKIF2A contributes to cell proliferation, migration, invasion and glycolysis in human neuroblastoma by regulating miR-129-5p/PLK4 axis." - hsa_circ_KIF2A - DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated "circKIF2A knockdown hampered tumorigenesis in vivo. CircKIF2A knockdown suppressed cell proliferation, migration, invasion and glycolysis via downregulating PLK4 expression through miR-129-5p." 2 "CircMMP11 regulates proliferation, migration, invasion, and apoptosis of breast cancer cells through miR-625-5p/ZEB2 axis." - hsa_circ_MMP11 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "CircMMP11/miR-625-5p/ZEB2 axis affected proliferation, migration, invasion, and apoptosis of BC cells through the mechanism of competing endogenous RNAs (ceRNA), indicating that circMMP11 was an oncogenic circRNA in BC." 4 Circ_0020123 Increases ZFX Expression to Facilitate Non-Small Cell Lung Cancer Progression by Sponging miR-142-3p. hsa_circ_0020123 - Circ_0020123 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "These findings suggested that circ_0020123 might be a potential therapy target for NSCLC, which could promote NSCLC progression through regulating the miR-142-3p/ZFX axis." 9 Circular RNA_PDHX Promotes the Proliferation and Invasion of Prostate Cancer by Sponging MiR-378a-3p. hsa_circ_0003768 hsa_circ_PDHX - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated circPDHX facilitated the proliferation and invasion of PCa cells by sponging miR-378a-3p. 2 Knockdown of circRAD23B Exerts Antitumor Response in Colorectal Cancer via the Regulation of miR-1205/TRIM44 axis. - hsa_circ_RAD23B - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated the inhibition of circRAD23B retarded the progression of CRC via acting on the miR-1205/TRIM44 axis. CircRAD23B might be a novel target in CRC treatment. 4 Silencing of circular RNA circPDE5A suppresses neuroblastoma progression by targeting the miR-362-5p/NOL4L axis. - hsa_circ_PDE5A - DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated "the knockdown of circPDE5A suppressed NB malignant progression at least in part by the regulation of the miR-362-5p/NOL4L axis, providing a novel rationale for developing circPDE5A as a potential target for NB management." 1 Inhibition of intervertebral disc disease progression via the circPKNOX1-miR-370-3p-KIAA0355 axis. - hsa_circ_PKNOX1 - DOID:90 degenerative disc disease intervertebral disc disease "RT-qPCR, microarray" up-regulated "We further demonstrated that circPKNOX1 played the role of a sponge by competitively binding miR-370-3p to reverse the inhibition of KIAA0355 expression. Our findings indicated that circPKNOX1 affected the progression of IVDD by regulating the expression of KIAA0355 via miR-370-3p. Therefore, circPKNOX1-based therapy may serve as an effective IVDD treatment strategy." 1 CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129. - hsa_circ_RAB11FIP1 - DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, RNA-seq" up-regulated "CircRAB11FIP1-induced autophagy accelerated EOC proliferation and invasion. Also, circRAB11FIP1 directly bound to miR-129 and regulated its targets ATG7 and ATG14. CircRAB11FIP1 bound to desmocollin 1to facilitate its interaction with ATG101." 1 CircCTNNA1 acts as a ceRNA for miR-363-3p to facilitate the progression of colorectal cancer by promoting CXCL5 expression. - hsa_circ_CTNNA1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "MiR-363-3p could be sponged by circCTNNA1, and the inhibition effect of circCTNNA1 silencing on CRC progression could be reversed by miR-363-3p inhibitor. Moreover, miR-363-3p could interact with CXCL5, and CXCL5 overexpression also could reverse the suppressive effect of miR-363-3p on CRC progression. " 1 Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis. - hsa_circ_VAPA - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircVAPA promotes chemotherapy resistance and malignant progression in GC by miR-125b-5p/STAT3 signaling. Our findings present novel insights into the mechanism by which circVAPA regulates chemotherapy resistance of GC cells. CircVAPA and miR-125b-5p may be considered as the potential targets for GC therapy. 1 Targeting choroidal vascular dysfunction via inhibition of circRNA-FoxO1 for prevention and management of myopic pathology. - hsa_circ_FoxO1 circRNA-FoxO1 DOID:11830 myopia myopia RT-qPCR up-regulated "circFoxO1 acted as the sponge of miR-145 to sequester and inhibit miR-145 activity, thereby inducing VEGFA or ANGPT2 expression. miR-145 could mimic the effects of circFoxO1 silencing on choroidal endothelial phenotypes. " 1 Circular RNA circVMA21 ameliorates lipopolysaccharide (LPS)-induced acute kidney injury by targeting the miR-199a-5p/NRP1 axis in sepsis. - hsa_circ_VMA21 circVMA21 DOID:0040085 bacterial sepsis Sepsis RT-qPCR down-regulated "CircVMA21 upregulation could attenuate LPS-triggered THP-1 cell injury through modulating the miR-199a-5p/NRP1 axis, hinting an underlying therapeutic strategy for sepsis patients." 2 "CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway." - hsa_circ_WAC - DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR down-regulated CircWAC/miR-142/WWP1 form a competing endogenous RNA (ceRNA) network to regulate PI3K/AKT signaling activity in TNBC cells and affect the chemosensitivity of cells. 1 Exosomal hsa_circ_0006859 is a potential biomarker for postmenopausal osteoporosis and enhances adipogenic versus osteogenic differentiation in human bone marrow mesenchymal stem cells by sponging miR-431-5p. hsa_circ_0006859 hsa_circ_ENC1 - DOID:11476 osteoporosis postmenopausal osteoporosis "RT-qPCR, microarray" up-regulated Exosomal hsa_circ_0006859 is a potential biomarker for postmenopausal osteoporosis and controls the balance between osteogenesis and adipogenesis in hBMSCs by sponging miR-431-5p. 1 Circular RNA circ_0079593 enhances malignant melanoma progression by the regulation of the miR-573/ABHD2 axis. hsa_circ_0079593 - circ_0079593 DOID:1909 melanoma malignant melanoma RT-qPCR up-regulated "Our findings identified that the knockdown of circ_0079593 suppressed melanoma progression at least partially through targeting the miR-573/ABHD2 axis, providing evidence for developing circ_0079593 as a promising therapeutic target for melanoma treatment." 2 Circ_0000003 regulates glutamine metabolism and tumor progression of tongue squamous cell carcinoma via the miR_330_3p/GLS axis. hsa_circ_0000003 - circ_0000003 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma RT-qPCR up-regulated "circ_0000003 facilitates TSCC cell proliferation, migration, invasion and glutamine catabolism by regulating the miR_330_3p/GLS pathway." 1 "Circ_0000511 accelerates the proliferation, migration and invasion, and restrains the apoptosis of breast cancer cells through the miR_326/TAZ axis." hsa_circ_0000511 - circ_0000511 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_0000511 upregulated the expression levels of TAZ partly via targeting miR_326 in BC cells. Circ_0000511 silencing restrained tumor growth in vivo. Circ_0000511 accelerated the proliferation, migration and invasion, while inhibiting the apoptosis of BC cells through upregulating TAZ expression via sponging miR_326. The circ_0000511/miR_326/TAZ axis may be a novel therapeutic target for BC treatment." 1 circ_0000212 promotes cell proliferation of colorectal cancer by sponging miR_491 and modulating FOXP4 expression. hsa_circ_0000212 - circ-0000212 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "miR_491 inhibited cell proliferation by targeting FOXP4. circ_0000212 was increased in CRC tissues and was predominantly localized in the cytoplasm. Furthermore, circ_0000212 augmented viability of the CRC cells by sponging miR_491 and modulating FOXP4. " 1 circRNA_0006896_miR1264_DNMT1 axis plays an important role in carotid plaque destabilization by regulating the behavior of endothelial cells in atherosclerosis. hsa_circ_0006896 - circRNA-0006896 DOID:1936 atherosclerosis atherosclerosis "RT-qPCR, microarray" up-regulated "the circRNA_0006896_miR-1264_DNMT1 axis plays an important role in carotid plaque destabilization by regulating the behavior of endothelial cells. Moreover, it suggests that circRNA_0006896 may represent a therapeutic target for controlling JNK/STAT3 signaling in HUVECs. Thus, this study may provide insight on potential interventions against vulnerable plaque formation in patients with AS." 1 Gain of circBRAF Represses Glioma Progression by Regulating miR-1290/FBXW7 Axis. - hsa_circ_BRAF - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circBRAF elevated FBXW7 expression by targeting miR-1290. Introduction of miR-1290 or FBXW7 knockdown could counteract the inhibitory effects of circBRAF upregulation on the malignant phenotypes of glioma cells. Overexpression of circBRAF repressed the tumor growth in vivo. Upregulation of circBRAF suppressed glioma evolvement in vitro and in vivo by regulating miR-1290/FBXW7 axis, broadening the cognition of glioma progression." 1 circUBAP2 regulates osteosarcoma progression via the miR_204_3p/HMGA2 axis. - hsa_circ_UBAP2 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circUBAP2 knockdown significantly inhibited OS cell malignant behavior by binding to miR_204_3p, which subsequently regulated HMGA2 expression. Therefore, the present study demonstrated that circUBAP2 expression was upregulated in OS, and circUBAP2 regulated OS cell malignant behavior via the miR_204_3p/HMGA2 axis." 5 "Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts." - hsa_circ_AFF2 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR down-regulated "Circ-AFF2 promoted proliferation, inflammatory response, migration, and invasion of RAFLSs by modulating the miR-650/CNP axis." 1 Serum hsa_circ_0054633 Is Elevated and Correlated with Clinical Features in Type 2 Diabetes Mellitus. hsa_circ_0054633 hsa_circ_PNPT1 - DOID:9352 type 2 diabetes mellitus type 2 diabetes mellitus RT-qPCR up-regulated Serum hsa_circ_0054633 is a potential noninvasive biomarker in discerning T2DM and is associated with changes in blood glucose and lipid. 3 Circular RNA circSPATA6 Inhibits the Progression of Oral Squamous Cell Carcinoma Cells by Regulating TRAF6 via miR-182. - hsa_circ_SPATA6 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "CircSPATA6 curbed migration and invasion, and expedited cell cycle arrest and apoptosis in OSCC cells partly through regulating the miR-182/TRAF6 axis. These findings hinted at an underlying circRNA-targeted therapy for OSCC." 1 Circular RNA circCLK3 promotes the progression of tongue squamous cell carcinoma via miR-455-5p/PARVA axis. - hsa_circ_CLK3 - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma RT-qPCR up-regulated "circCLK3 exerts its carcinogenic effects on TSCC progression via absorbing miR-455-5p to upregulate PARVA, which expands our knowledge on the underlying mechanism of TSCC." 1 circCUX1 promotes neuroblastoma progression and glycolysis by regulating the miR-338-3p/PHF20 axis. - hsa_circ_CUX1 - DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated "circCUX1 silencing hindered tumor growth in vivo. circCUX1 depletion suppressed tumor progression and glycolysis in NB by regulating miR-338-3p/PHF20 axis, suggesting a potential biomarker for NB treatment." 3 Circular RNA circGLIS3 promotes bladder cancer proliferation via the miR-1273f/SKP1/Cyclin D1 axis. - hsa_circ_GLIS3 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circGLIS3 upregulates the expression of SKP1 by adsorbing miR-1273f and then promotes cyclin D1 expression, ultimately promoting the proliferation of bladder cancer cells. In summary, our study indicates that circGLIS3 plays an oncogene role in the development of bladder cancer and has potential to be a candidate for bladder cancer." 1 Knockdown of circROBO2 attenuates acute myocardial infarction through regulating the miR-1184/TRADD axis. - hsa_circ_ROBO2 - DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR up-regulated "Knockdown of circROBO2 reduced the apoptosis of cardiomyocytes by increasing the expression levels of miR-1184, which in turn decreased the expression levels of TRADD in the myocardium post-MI." 1 Knockdown of Circ_SLC39A8 protects against the progression of osteoarthritis by regulating miR-591/IRAK3 axis. - hsa_circ_SLC39A8 circ_SLC39A8 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Our findings indicated that knockdown of circ_SLC39A8 delayed the progression of OA via modulating the miR-591-IRAK3 axis, providing new insight into the molecular mechanisms of OA pathogenesis." 1 "Circular RNA circSOX4 promotes the proliferation, migration and apoptosis of hepatocellular carcinoma cells by down regulating microRNA-432 expression." - hsa_circ_SOX4 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircSOX4, highly expressed in HCC, indicates a poor prognosis. CircSOX4 may mediate the progression of HCC by binding to microRNA-432." 1 "CircPRKCI regulates proliferation, migration and cycle of lung adenocarcinoma cells by targeting miR-219a-5p-regulated CAMK1D." - hsa_circ_PRKCI - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "CircPRKCI is significantly highly expressed in LUAD, and the highly expressed circPRKCI is capable of facilitating LUAD cell migration, proliferation and cycle. CircPRKCI may regulate the malignant phenotype of LUAD via the miR-219a-5p/CAMK1D axis." 3 "Serum Exosomes-Based Biomarker circ_0008928 Regulates Cisplatin Sensitivity, Tumor Progression, and Glycolysis Metabolism by miR-488/HK2 Axis in Cisplatin-Resistant Nonsmall Cell Lung Carcinoma." hsa_circ_0008928 - circ_0008928 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0008928 knockdown improved CDDP sensitivity and hindered cell proliferation, migration, invasion, and glycolysis metabolism by miR-488/HK2 axis in CDDP-resistant NSCLC. This finding provides a new mechanism for studying CDDP-resistant therapy in NSCLC." 1 Circular RNA circCSPP1 knockdown attenuates doxorubicin resistance and suppresses tumor progression of colorectal cancer via miR-944/FZD7 axis. - hsa_circ_CSPP1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Our data indicated that circCSPP1 knockdown inhibited DOX-resistant CRC cell growth and enhanced doxorubicin sensitivity by miR-944/FZD7 axis, providing a potential target for CRC therapy." 3 circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression. hsa_circ_0004338 hsa_circ_CAMSAP1 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated circCAMSAP1 act as a microRNA sponge and suggest a new therapeutic target of human osteosarcoma. 1 Circ-LAMP1 contributes to the growth and metastasis of cholangiocarcinoma via miR-556-5p and miR-567 mediated YY1 activation. - hsa_circ_LAMP1 - DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR up-regulated "circ-LAMP1 directly sponged miR-556-5p and miR-567, thereby releasing their suppression on YY1 at post-transcriptional level. Rescue assay indicated that the oncogenic role of circ-LAMP1 is partially dependent on its modulation of YY1 in CCA." 1 CircRNA circ-IQGAP1 Knockdown Alleviates Interleukin-1beta-Induced Osteoarthritis Progression via Targeting miR-671-5p/TCF4. - hsa_circ_IQGAP1 - DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "Circ-IQGAP1 knockdown attenuated IL-1beta-caused chondrocyte apoptosis, inflammatory injury, and extracellular matrix degradation. Circ-IQGAP1 could regulate miR-671-5p/TCF4 axis to modulate IL-1beta-caused chondrocyte damage. Circ-IQGAP1 might act as a new target for the treatment of OA." 1 c-Myc-induced circ-NOTCH1 promotes aggressive phenotypes of nasopharyngeal carcinoma cells by regulating the miR-34c-5p/c-Myc axis. - hsa_circ_NOTCH1 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated c-Myc-induced circ-NOTCH1 promoted malignant phenotypes of NPC cells by regulating the miR-34c-5p/c-Myc axis. 1 Circular RNA circ_0021093 regulates miR-432/Annexin A2 pathway to promote hepatocellular carcinoma progression. hsa_circ_0021093 - circ_0021093 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circ_0021093 boosted HCC progression via regulating proliferation, migration and invasion of HCC cells by acting as competing endogenous RNA to sponge miR-432." 2 Hsa_circ_0099198 facilitates the progression of retinoblastoma by regulating miR-1287/LRP6 axis. hsa_circ_0099198 hsa_circ_TRHDE - DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated "circ_0099198 contributed to RB progression by sponging miR-1287 and up-regulating LRP6, which provided novel biomarkers for RB therapy." 1 Circular RNA circRNA_0000094 sponges microRNA-223-3p and up-regulate F-box and WD repeat domain containing 7 to restrain T cell acute lymphoblastic leukemia progression. hsa_circ_0000094 - circRNA_0000094 DOID:5603 T-cell acute lymphoblastic leukemia T-cell acute lymphoblastic leukemia RT-qPCR up-regulated circ_0000094 impedes T-ALL progression by modulating the miR-223-3p/FBW7 axis. 1 "Identification of Plasma hsa_circ_0005397 and Combined With Serum AFP, AFP-L3 as Potential Biomarkers for Hepatocellular Carcinoma." hsa_circ_0005397 hsa_circ_RHOT1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Plasma has_circ_0005397 represents a novel noninvasive biomarker for HCC. Moreover, the combination of plasma hsa_cic_0005397, serum AFP and AFP-L3 might improve the diagnostic value for HCC." 3 Knockdown of circRNA circ_0087378 Represses the Tumorigenesis and Progression of Esophageal Squamous Cell Carcinoma Through Modulating the miR-140-3p/E2F3 Axis. hsa_circ_0087378 hsa_circ_NTRK2 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "circ_0087378 might act as a competing endogenous RNA for miR-140-3p, which could inhibit the tumorigenesis and progression of ESCC through upregulating E2F3 expression." 2 CircHIPK3 Promotes the Tumorigenesis and Development of Gastric Cancer Through miR-637/AKT1 Pathway. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "A new circular RNA circHIPK3 and its function are identified, and the regulatory pathway of circHIPK3/miR-637/AKT1 in the tumorigenesis and development of gastric cancer is discovered." 6 Circular RNA POSTN Promotes Myocardial Infarction-Induced Myocardial Injury and Cardiac Remodeling by Regulating miR-96-5p/BNIP3 Axis. - hsa_circ_Postn - DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated circPostn contributes to MI-induced myocardial injury and cardiac remodeling by regulating miR-96-5p/BNIP3 axis. 1 Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway. - hsa_circ_PRKCA - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Curcumin inhibited NSCLC growth through downregulating circ-PRKCA, which regulated ITGB1 expression by adsorbing miR-384. This study provided a new mechanism to understand how curcumin inhibited the progression of NSCLC." 1 "Circ_0134111 knockdown relieves IL-1beta-induced apoptosis, inflammation and extracellular matrix degradation in human chondrocytes through the circ_0134111-miR-515-5p-SOCS1 network." hsa_circ_0134111 - circ_0134111 DOID:8398 osteoarthritis Osteoarthritis RT-qPCR up-regulated "Circ_0134111 knockdown alleviated apoptosis, inflammatory responses and ECM degradation in OA cell model by mediating the miR-515-5p-SOCS1 network, hinting that circ_0134111 was involved in OA progression." 2 Circular RNA circ_0000467 regulates colorectal cancer development via miR-382-5p/EN2 axis. hsa_circ_0000467 - circ_0000467 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "circ_0000467 facilitates CRC development by modulating the miR-382-5p/EN2 axis, and circ_0000467 is a promising target for CRC therapy." 4 CircTP63 promotes hepatocellular carcinoma progression by sponging miR-155-5p and upregulating ZBTB18. - hsa_circ_TP63 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Our data highlight a critical circTP63-miR-155-5p-ZBTB18 regulatory network involved in the HCC progression, gaining mechanistic insights into the function of circRNAs in HCC progression, and providing effective biomarkers and therapeutic targets for HCC treatment." 1 Circ_DOCK1 regulates USP11 through miR-132-3p to control colorectal cancer progression. - hsa_circ_DOCK1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_DOCK1 interference suppressed cell growth and metastasis, and increased apoptosis of colorectal cancer via decreasing USP11 by increasing miR-132-3p." 4 Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer. - hsa_circ_RHOT1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated we discovered that circRHOT1 contributed to malignant progression and attenuated ferroptosis in breast cancer by the miR-106a-5p/STAT3 axis. Our finding provides new insights into the mechanism by which circRHOT1 promotes the development of breast cancer. CircRHOT1 and miR-106a-5p may serve as potential targets for breast cancer therapy. 1 Circ_0074027 contributes to non-small cell lung cancer progression through positively modulating RHOA via sequestering miR-2467-3p. hsa_circ_0074027 - circ_0074027 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ_0074027 accelerated NSCLC progression by binding to miR-2467-3p to induce RHOA expression. 2 The Expression Pattern and Clinicopathological Importance of Hsa_circ_000425 in Colorectal Cancer. hsa_circ_000425 - hsa_circ_000425 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated hsa_circ_000425 may have a role in the pathogenesis of CRC. 1 IGF2R circular RNA hsa_circ_0131235 expression in the middle temporal cortex is associated with AD pathology. hsa_circ_0131235 - - DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, RNA-seq" up-regulated Elevated hsa_circ_0131235 expression in the MT cortex was significantly associated with AD pathology. 1 Circular RNA TRAPPC6B inhibits intracellular Mycobacterium tuberculosis growth while inducing autophagy in macrophages by targeting microRNA-874-3p. - hsa_circ_TRAPPC6B - DOID:399 tuberculosis tuberculosis RT-qPCR down-regulated circTRAPPC6B antagonises the ability of miR-874-3p to suppress ATG16L1 expression and activate and enhance autophagy sequestration to restrict Mtb growth in macrophages. 2 Analysis and Validation of circRNA-miRNA Network in Regulating m(6)A RNA Methylation Modulators Reveals CircMAP2K4/miR-139-5p/YTHDF1 Axis Involving the Proliferation of Hepatocellular Carcinoma. - hsa_circ_MAP2K4 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated hsa_circ_0007456(circMAP2K4) was validated to promote HCC cell proliferation by binding with hsa-miR-139-5p to promote YTHDF1 expression. 1 Circ_0085289 Alleviates the Progression of Periodontitis by Regulating let-7f-5p/SOCS6 Pathway. hsa_circ_0085289 - circ_0085289 DOID:824 periodontitis periodontitis RT-qPCR down-regulated "Circ_0085289 alleviated PDLC injury induced by LPS stimulation via modulating let-7f-5p/SOCS6 axis, suggesting a promising biomarker for periodontitis treatment." 1 Porcine circovirus type 2 infection activates NF-kappaB pathway and cellular inflammatory responses through circPDCD4/miR-21/PDCD4 axis in porcine kidney 15 cell. - hsa_circ_PDCD4 circPDCD4 DOID:0050117 disease by infectious agent postweaning multisystemic wasting syndrome RT-qPCR up-regulated "Thus, PCV2 activated the NF-¦ĘB pathway and cellular inflammatory responses through regulating circPDCD4, miR-21, and PDCD4 in PK-15 cells." 1 "Circ-RNF13, as an oncogene, regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2." hsa_circ_0067717 hsa_circ_RNF13 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circ-RNF13 might sponge miR-424-5p to suppress HBV-associated HCC cells malignant progression and HBV infection by regulating TGIF2, providing a novel insight into the occurrence and treatment of HBV-associated HCC." 1 CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation. - hsa_circ_HIF1A - DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, microarray" up-regulated circHIF1A played a critical role in the growth and metastasis of TNBC via a positive feedback loop and that circHIF1A could be a promising biomarker for breast cancer diagnosis and a potential therapeutic target for TNBC treatment. 1 Circ-KIAA0907 inhibits the progression of oral squamous cell carcinoma by regulating the miR-96-5p/UNC13C axis. - hsa_circ_KIAA0907 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "circ-KIAA0907 restrains OSCC progression via the miR-96-5p/UNC13C axis, indicating that it may be a potential target for OSCC treatment." 1 Silencing circRNA protein kinase C iota (circ-PRKCI) suppresses cell progression and glycolysis of human papillary thyroid cancer through circ-PRKCI/miR-335/E2F3 ceRNA axis. - hsa_circ_PRKCI - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "circ-PRKCI exerted oncogenic role in PTC by antagonizing cell progression and glycolysis via regulating miR-335/E2F3 axis, suggesting circ-PRKCI was a potential biomarker and target for PTC." 1 Increased Expression of hsa_circ_0002111 and Its Clinical Significance in Papillary Thyroid Cancer. hsa_circ_0002111 hsa_circ_PSD3 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "the over-expression of hsa_circ_0002111 promotes PTC, and thus hsa_circ_0002111 may be a potential diagnostic biomarker and therapeutic target for PTC." 5 Circular RNA circ_0057558 Controls Prostate Cancer Cell Proliferation Through Regulating miR-206/USP33/c-Myc Axis. hsa_circ_0057558 - circ_0057558 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated circ_0057558 gives an impetus to cell proliferation and cell cycle control in prostate cancer cell lines by sponging miR-206 and positively regulating the transcription of the miR-206 target gene USP33. 2 Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4. hsa_circ_0003420 - circ_0003420 DOID:409 liver disease sepsis-induced liver damage RT-qPCR up-regulated We demonstrate that circ_0003420 targets NPAS4 mRNA thereby mediating the cell damage and inflammation caused by LPS. This study provides a possible target for treatment of liver damage induced by sepsis. 1 Circular RNA circAFF2 accelerates gastric cancer development by activating miR-6894-5p and regulating ANTXR 1 expression. - hsa_circ_AFF2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircAFF2 acts as an oncogene in gastric cancer and exerts its effects via miR-6894-5p/ANTXR 1 signaling. 1 Exosome-Mediated Transfer of circ_0000338 Enhances 5-Fluorouracil Resistance in Colorectal Cancer through Regulating MicroRNA 217 (miR-217) and miR-485-3p. hsa_circ_0000338 - circ_0000338 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "The delivery of circ_0000338 via exosomes enhanced 5-FU resistance in CRC through negative regulation of miR-217 and miR-485-3p, indicating a promising diagnostic and therapeutic marker for 5-FU-based chemotherapy in CRC patients." 2 Circ-PITX1 Promotes the Progression of Non-Small Cell Lung Cancer Through Regulating the miR-1248/CCND2 Axis. - hsa_circ_PITX1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ-PITX1 served as a sponge of miR-1248 to promote NSCLC progression by upregulating CCND2. 3 Circular RNA circRNA_101996 promoted cervical cancer development by regulating miR-1236-3p/TRIM37 axis. - - circRNA_101996 DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated "circRNA_101996/miR-1236-3p/TRIM37 axis accelerated cervical cancer development, providing novel insights into cervical cancer diagnosis and treatment." 1 Hsa_circ_0002162 has a critical role in malignant progression of tongue squamous cell carcinoma through targeting miR-33a-5p. hsa_circ_0002162 hsa_circ_PTK2 - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma RT-qPCR up-regulated hsa_circ_0002162 had an important role in malignant progression of TSCC through targeting miR-33a-5p. 2 CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated beta-catenin stabilization. - hsa_circ_FAM73A - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our work demonstrates the crucial role of circFAM73A in the CSC-like properties of GC and uncovers a positive feedback loop in circFAM73A regulation that leads to the progression of gastric cancer, which may provide new insights into circRNA-based diagnostic and therapeutic strategies." 1 Circ_0005927 Inhibits the Progression of Colorectal Cancer by Regulating miR-942-5p/BATF2 Axis. hsa_circ_0005927 - circ_0005927 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0005927 suppressed cell colony-forming ability, migration and invasion, and promoted cell apoptosis by sponging miR-942-5p to induce BATF2 in CRC. The possible mechanism provides a theoretical basis for the study of circRNA-directed therapy for CRC." 2 CircPVT1 up-regulation attenuates steroid-induced osteonecrosis of the femoral head through regulating miR-21-5p-mediated Smad7/TGFbeta signalling pathway. - rno_circ_PVT1 - DOID:10159 osteonecrosis steroid-induced osteonecrosis of the femoral head RT-qPCR up-regulated CircPVT1 exerts protective effects against SIONFH via modulating miR-21-5p-mediated Smad7/TGFbeta pathway. 1 Circular RNA ZNF609 functions as a competing endogenous RNA in regulating E2F transcription factor 6 through competitively binding to microRNA-197-3p to promote the progression of cervical cancer progression. - hsa_circ_ZNF609 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circ-ZNF609 promoted CC progression through modulating the miR-197-3p/E2F6 axis as an oncogene. This finding offers a unique insight into CC molecular mechanism and suggests a potential target for CC therapy. 1 CircRNA circ_0006892 regulates miR-24/PHLPP2 axis to mitigate cigarette smoke extract-induced bronchial epithelial cell injury. hsa_circ_0006892 - circ_0006892 DOID:3083 chronic obstructive pulmonary disease chronic obstructive pulmonary disease RT-qPCR up-regulated "PHLPP2 was targeted via miR-24, and miR-24 knockdown mitigated CSE-induced viability reduction and promotion of apoptosis and inflammatory response via regulating PHLPP2. Circ_0006892 could promote PHLPP2 expression via regulating miR-24. Circ_0006892 attenuated CSE-induced bronchial epithelial cell apoptosis and inflammatory response via regulating miR-24/PHLPP2 axis." 1 "Silencing of circular RNA_0000326 inhibits cervical cancer cell proliferation, migration and invasion by boosting microRNA-338-3p-dependent down-regulation of CDK4." hsa_circ_0000326 - circ_0000326 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circ_0000326 exerted oncogenic effects on cervical cancer by upregulating Cyclin-dependent kinase 4 via sponging microRNA-338-3p. This systematic investigation on circ_0000326 could provide further insight into cervical cancer. 2 Overexpression of circ_CELSR1 facilitates paclitaxel resistance of ovarian cancer by regulating miR-149-5p/SIK2 axis. - hsa_circ_CELSR1 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "MiR-149-5p overexpression suppressed paclitaxel resistance and cell progression in paclitaxel-resistant ovarian cancer cells by interacting with SIK2. In addition, circ_CELSR1 silencing impeded paclitaxel resistance of ovarian cancer in vivo. Circ_CELSR1 improved the resistance of ovarian cancer to paclitaxel by regulating miR-149-5p/SIK2 axis." 3 Circular RNA circ_0005774 contributes to proliferation and suppresses apoptosis of acute myeloid leukemia cells via circ_0005774/miR-192-5p/ULK1 ceRNA pathway. hsa_circ_0005774 - circ_0005774 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated circ_0005774 knockdown repressed cell proliferation and promoted apoptosis of AML cells partially through regulating miR-192-5p/ULK1 axis. 1 Circ-HIPK3 regulates YAP1 expression by sponging miR-381-3p to promote oral squamous cell carcinoma development. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Circ-HIPK3 contributed to OSCC growth and development through regulating YAP1 expression by sponging miR-381-3p, indicating a promising therapeutic strategy for OSCC." 3 Circular RNA VRK1 facilitates pre-eclampsia progression via sponging miR-221-3P to regulate PTEN/Akt. - hsa_circ_VRK1 - DOID:10591 pre-eclampsia preeclampsia "RT-qPCR, microarray" up-regulated "circVRK1 suppresses trophoblast cell migration, invasion and EMT, by acting as a ceRNA to miR-221-3p to regulate PTEN, and further inhibit PI3K/Akt activation. The purpose of this paper is to open wide insights to investigate the onset of PE and provide new potential therapeutic targets in PE." 1 CircSPI1 acts as an oncogene in acute myeloid leukemia through antagonizing SPI1 and interacting with microRNAs. - hsa_circ_SPI1 - DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, RNA-seq" up-regulated we illustrate the clinical significance of circSPI1 by showing that circSPI1-regulated genes are associated with the clinical outcome of AML patients. Our data provide new insight into the complex SPI1 gene regulation now involving circSPI1. 2 N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway. - hsa_circ_CUX1 - DOID:8533 hypopharynx cancer hypopharyngeal cancer "RT-qPCR, RNA-seq" up-regulated "circCUX1 binds to Caspase1 and inhibits its expression, resulting in a decrease in the release of inflammatory factors, thereby developing tolerance to radiotherapy. Our findings indicate that circCUX1 is a potential therapeutic target for radiotherapy tolerance in HPSCC patients." 1 Circular RNA SMARCA5 functions as an anti-tumor candidate in colon cancer by sponging microRNA-552. - hsa_circ_SMARCA5 - DOID:219 colon cancer colon cancer RT-qPCR up-regulated circSMARCA5 inactivated Wnt and YAP1 pathways by inhibiting miR-552. Anti-tumor role of sircSMARCA5 was showed in colon cancer cells as sponging miR-552 and blocking Wnt and YAP1 pathways. 1 The identification of circular RNAs from peripheral blood mononuclear cells in systemic lupus erythematosus. - - hsa_circRNA_100236 DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated "The correlation analysis revealed that has_circRNA_100236, has_circRNA_102489, and has_circRNA_101413 were correlated with positive anti-dsDNA, thrombocytopenia, and positive IgG, respectively. Lastly, their miRNAs targets and the binding sites were predicted." 1 The identification of circular RNAs from peripheral blood mononuclear cells in systemic lupus erythematosus. - - hsa_circRNA_102489 DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated "The correlation analysis revealed that has_circRNA_100236, has_circRNA_102489, and has_circRNA_101414 were correlated with positive anti-dsDNA, thrombocytopenia, and positive IgG, respectively. Lastly, their miRNAs targets and the binding sites were predicted." 1 The identification of circular RNAs from peripheral blood mononuclear cells in systemic lupus erythematosus. - - hsa_circRNA_101413 DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, microarray" up-regulated "The correlation analysis revealed that has_circRNA_100236, has_circRNA_102489, and has_circRNA_101415 were correlated with positive anti-dsDNA, thrombocytopenia, and positive IgG, respectively. Lastly, their miRNAs targets and the binding sites were predicted." 1 CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing. hsa_circ_0001460 hsa_circ_NEIL3 circNEIL3 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" up-regulated "circNEIL3 facilitates the proliferation and metastasis of PDAC through the circNEIL3/miR-432-5p/ADAR1/GLI1/cell cycle and EMT axis and that its expression is regulated by ADAR1 through a negative feedback loop. Therefore, circNEIL3 may serve as a prognostic marker and a therapeutic target for PDAC." 1 CircSEC24A promotes IL-1beta-induced apoptosis and inflammation in chondrocytes by regulating miR-142-5p/SOX5 axis. - hsa_circ_SEC24A - DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "CircSEC24A aggravated IL-1beta-induced injury via modulating miR-142-5p/SOX5 axis, providing possible targets for the clinical diagnosis and treatment of OA." 3 N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization. - - circ1662 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq, microarray" up-regulated METTL3-induced circ1662 promoted CRC cell invasion and migration by accelerating YAP1 nuclear transport. This result implies that circ1662 is a new prognostic and therapeutic marker for CRC metastasis. 1 Circ_0023028 contributes to the progression of laryngeal squamous cell carcinoma by upregulating LASP1 through miR-486-3p. hsa_circ_0023028 - Circ_0023028 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "Circ_0023028 knockdown might impede the progression of LSCC by regulating miR-486-3p/LASP1 axis, which could provide a novel insight on the mechanism of LSCC progression." 1 A circular RNA derived from PLXNB2 as a valuable predictor of the prognosis of patients with acute myeloid leukaemia. - hsa_circ_PLXNB2 - DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "we validated the high expression of circPLXNB2 and PLXNB2 in patients with AML. Elevated circPLXNB2 levels were associated with poor clinical outcomes in patients with AML. Importantly, circPLXNB2 accelerated tumour growth and progression, possibly by regulating PLXNB2 expression. Our study highlights the potential of circPLXNB2 as a new prognostic predictor and therapeutic target for AML in the future." 2 "CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis." - hsa_circ_RSF1 circRSF1 DOID:1936 atherosclerosis Atherosclerosis RT-qPCR up-regulated "CircRSF1 regulated ox-LDL-induced vascular endothelial cell proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in AS, providing new perspectives and methods for the treatment and diagnosis of AS." 3 "Circular RNA hsa_circ_0072309 inhibits the proliferation, invasion and migration of gastric cancer cells via inhibition of PI3K/AKT signaling by activating PPARgamma/PTEN signaling." hsa_circ_0072309 hsa_circ_LIFR - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "hsa_circ_0072309 inhibited proliferation, invasion and migration of gastric cancer cells via the inhibition of PI3K/AKT signaling by activating the PPARgamma/PTEN signaling pathway. Targeting hsa_circ_0072309 may be an innovative therapeutic strategy for the treatment of GC." 2 "Circular RNA_0074027 participates in cell proliferation, apoptosis and metastasis of colorectal cancer cells through regulation of miR_525_3p." hsa_circ_0074027 - cirRNA_0074027 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "The addition of miRNA_525_3p inhibitors could reverse the anti_tumor effects induced by the deletion of circRNA_0074027. The downregulation of cirRNA_0074027 inhibited tumor progression via sponging miR_525_3p, which could be a promising treatment bio_marker for CRC." 1 Circular RNA circ_CCT3 promotes hepatocellular carcinoma progression by regulating the miR_1287_5p/TEAD1/PTCH1/LOX axis. - hsa_circ_CCT3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circular RNA circ_CCT3 promotes hepatocellular carcinoma progression by regulating the miR_1287_5p/TEAD1/PTCH1/LOX axis. 3 "Circular RNA ABCB10 promotes cell proliferation and invasion, but inhibits apoptosis via regulating the microRNA_1271_mediated Capn4/Wnt/beta_catenin signaling pathway in epithelial ovarian cancer." - hsa_circ_ABCB10 - DOID:2152 ovary epithelial cancer epithelial ovarian cancer RT-qPCR down-regulated "circ_ABCB10 promoted cell proliferation and invasion, and suppressed apoptosis by regulating the miR_1271_mediated Capn4/Wnt/beta_catenin signaling pathway in EOC." 2 "Circular RNA hsa_circ_0001666 sponges miR_330_5p, miR_193a_5p and miR_326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4." hsa_circ_0001666 hsa_circ_FAM120B - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated "hsa_circ_0001666 may function as an oncogene, promoting PTC tumorigenesis via the miR_330_5p/miR_193a_5p/miR_326/ETV4 pathway. This provides a basis for identifying potential novel therapeutic targets for PTC." 1 "CircPITX1 Regulates Proliferation, Angiogenesis, Migration, Invasion, and Cell Cycle of Human Glioblastoma Cells by Targeting miR-584-5p/KPNB1 Axis." - hsa_circ_PITX1 - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated "circPITX1/miR-584-5p/KPNB1 axis regulated GBM process via mediating proliferation, angiogenesis, migration, invasion, and cell cycle process of GBM cells." 3 New biomarker for lung cancer - focus on circSETD3. hsa_circ_0000567 hsa_circ_SETD3 - DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" down-regulated "circSETD3 can be used as a novel biomarker for lung cancer. It relieves miR-520h degradation of the transporter ABCG2 by down-regulating the miR-520h expression, causing gefitinib to be pumped out of the cell." 1 Circular RNA PPP1CC promotes Porphyromonas gingivalis-lipopolysaccharide-induced pyroptosis of vascular smooth muscle cells by activating the HMGB1/TLR9/AIM2 pathway. - hsa_circ_PPP1CC - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Knockdown of circRNA PPP1CC relieved Pg-LPS-induced pyroptosis of VSMCs. Pyroptosis of VSMCs appears to promote atherosclerosis and may represent a novel therapeutic target for its treatment. 1 CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR-485-5p/SLC38A1 axis. - hsa_circ_RUNX1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "CircRUNX1 promoted CRC cell growth, metastasis and glutamine metabolism and repressed apoptosis by elevating SLC38A1 through sponging miR-485-5p, which might provide a novel target for CRC treatment." 2 Circ_HIPK3 alleviates CoCl(2)-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:319 spinal cord disease spinal cord injury RT-qPCR down-regulated The regulation of circ_HIPK3 in CoCl(2)-induced injury of AGE1.HN cells was associated with the upregulation of DUSP19. Circ_HIPK3 acted as a pathogenic inhibitor in the progression of SCI via the miR-222-3p-mediated DUSP19 upregulation. 2 circ-Keratin 6c Promotes Malignant Progression and Immune Evasion of Colorectal Cancer through microRNA-485-3p/Programmed Cell Death Receptor Ligand 1 Axis. - hsa_circ_KRT6C - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ-keratin 6c could increase programmed cell death receptor ligand 1 expression by functioning as a microRNA-16-5p sponge, which promoted malignant progression and immune evasion of colorectal cancer." 1 Circ-SKA3 upregulates ID3 expression by decoying miR-326 to accelerate the development of medulloblastoma. - hsa_circ_SKA3 - DOID:0050902 medulloblastoma medulloblastoma RT-qPCR up-regulated "circ-SKA3 functioned as an oncogene to promote the development of MB by increasing ID3 expression via decoying miR-326, hinting that circ-SKA3 might be a therapeutic target of MB." 4 Upregulation of circ-ASPH contributes to glioma cell proliferation and aggressiveness by targeting the miR-599/AR/SOCS2-AS1 signaling pathway. - hsa_circ_ASPH - DOID:0060108 brain glioma glioma "RT-qPCR, microarray" up-regulated circ-ASPH/miR-599/AR/SOCS2-AS1 signaling may be a promising biomarker/therapeutic target for GM. 1 Circular RNA CHST15 Sponges miR-155-5p and miR-194-5p to Promote the Immune Escape of Lung Cancer Cells Mediated by PD-L1. - hsa_circ_CHST15 - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated CircCHST15 sponged miR-155-5p and miR-194-5p to promote the PD-L1-mediated immune escape of lung cancer cells. 1 circKLHL24 Blocks Breast Cancer Development by Regulating the miR-1204/ALX4 Network. - hsa_circ_KLHL24 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circKLHL24 blocked the progression of breast cancer by activating ALX4 through targeting miR-1204, which might be a novel perspective to understand the pathogenesis of breast cancer." 1 Silencing of hsa_circ_0009035 Suppresses Cervical Cancer Progression and Enhances Radiosensitivity through MicroRNA 889-3p-Dependent Regulation of HOXB7. hsa_circ_0009035 hsa_circ_RACGAP1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "hsa_circ_0009035 as an important regulator of CC progression and radioresistance at least in part through targeting the miR-889-3p/HOXB7 axis, highlighting its significance as a potential therapeutic target for CC treatment." 2 Circular RNA hsa_circ_0005397 promotes hepatocellular carcinoma progression by regulating the miR-326/PDK2 axis. hsa_circ_0005397 hsa_circ_RHOT1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Hsa_circ_0005397 facilitates HCC progression by regulating the miR-326/PDK2 axis, providing a promising circRNA-targeted therapy for HCC." 3 Androgen receptor decreases renal cell carcinoma bone metastases via suppressing the osteolytic formation through altering a novel circEXOC7 regulatory axis. - hsa_circ_EXOC7 - DOID:4451 renal carcinoma renal carcinoma "RT-qPCR, microarray" up-regulated "AR/DHX9/circEXOC7/miR-149-3p/CSF1 signaling acts as a valuable feature in the bone metastasis of renal cancer, which may benefit in suppressing the RBM progression." 1 Novel circular RNA circSOBP governs amoeboid migration through the regulation of the miR-141-3p/MYPT1/p-MLC2 axis in prostate cancer. - hsa_circ_SOBP - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated circSOBP suppresses amoeboid migration of PCa cells and inhibits migration and invasion through sponging miR-141-3p and regulating the MYPT1/p-MLC2 axis. 1 Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR_330_3p/PNN axis. hsa_circ_0032463 hsa_circ_SIPA1L1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "this study confirmed that by regulating the miR_330_3p/PNN axis, circular RNA circ_0032463 could function as a tumor enhancer in cells with OS." 3 Identification of circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Integrated Analysis. hsa_circ_0008035 hsa_circ_EXT1 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR dysregulated We speculate that hsa_circ_0008035/hsa-miR-107/MSRB3 and hsa_circ_0028173/hsa-miR-338-3p/TPX2/GATA3 interaction pairs may play a vital role in BC. 2 Identification of circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Integrated Analysis. hsa_circ_0028173 hsa_circ_ATP2A2 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR dysregulated We speculate that hsa_circ_0008035/hsa-miR-107/MSRB3 and hsa_circ_0028173/hsa-miR-338-3p/TPX2/GATA3 interaction pairs may play a vital role in BC. 1 Circular RNA_0000629 Suppresses Bladder Cancer Progression Mediating MicroRNA-1290/CDC73. hsa_circ_0000629 - circ_0000629 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, microarray" up-regulated "Circ_0000629 promotes the expression of CDC73 by competitively binding to miR-1290, thereby inhibiting the growth and metastasis of BC cells." 1 Downregulation of Circ_0071589 Suppresses Cisplatin Resistance in Colorectal Cancer by Regulating the MiR-526b-3p/KLF12 Axis. hsa_circ_0071589 - circ_0071589 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Knockdown of circ_0071589 repressed CDDP resistance in CDDP-resistant CRC cells by regulating the miR-526b-3p/KLF12 axis. 2 Comparative Transcriptomic Analysis to Identify the Important Coding and Non-coding RNAs Involved in the Pathogenesis of Pterygium. hsa_circ_0007482 hsa_circ_COL5A1 - DOID:2116 pterygium pterygium "RT-qPCR, RNA-seq" up-regulated several circRNAs including hsa_circ_0007482 and hsa_circ_001730 were considered to be involved in the pterygium development. 1 Comparative Transcriptomic Analysis to Identify the Important Coding and Non-coding RNAs Involved in the Pathogenesis of Pterygium. hsa_circ_001730 - hsa_circ_001730 DOID:2116 pterygium pterygium "RT-qPCR, RNA-seq" up-regulated several circRNAs including hsa_circ_0007482 and hsa_circ_001730 were considered to be involved in the pterygium development. 1 CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway. - hsa_circ_ABCC3 - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated CircABCC3 regulated glioblastoma development via miR-770-5p/SOX2 axis through PI3K/AKT pathway. This finding lays a theoretical foundation for studying circRNA-directed therapy for glioblastoma. 1 "CircHIPK3/miR-381-3p axis modulates proliferation, migration, and glycolysis of lung cancer cells by regulating the AKT/mTOR signaling pathway." hsa_circ_0000284 hsa_circ_HIPK3 - DOID:1324 lung cancer lung cancer RT-qPCR up-regulated circHIPK3 knockdown suppressed tumor growth in vivo by inactivating the AKT/mTOR signaling pathway. 4 CircSAMD4A contributes to cell doxorubicin resistance in osteosarcoma by regulating the miR-218-5p/KLF8 axis. - hsa_circ_SAMD4A - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circSAMD4A enhanced cell DXR resistance in osteosarcoma by regulating the miR-218-5p/KLF8 axis, suggesting a novel therapeutic target for therapy-resistant osteosarcoma." 2 Circ_0091579 enhances the malignancy of hepatocellular carcinoma via miR-1287/PDK2 axis. hsa_circ_0091579 - Circ_0091579 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ_0091579 deteriorated HCC by promoting the proliferation and glycolytic metabolism and suppressing the apoptosis of HCC cells via miR-1287/PDK2 axis. 6 "Circ_GRN Promotes the Proliferation, Migration, and Inflammation of Vascular Smooth Muscle Cells in Atherosclerosis Through miR-214-3p/FOXO1 Axis." - hsa_circ_GRN - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "circ_GRN promoted the proliferation, migration, and inflammation of HVSMCs through miR-214-3p/FOXO1 axis in ox-LDL-induced AS model in vitro, suggesting the potential involvement in an AS process, which provided a potential candidate for future clinic intervention in AS." 3 CircFAT1 facilitates cervical cancer malignant progression by regulating ERK1/2 and p38 MAPK pathway through miR-409-3p/CDK8 axis. - hsa_circ_FAT1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "CircFAT1 promoted CC progression via activating ERK1/2 and p38 MAPK pathway through the miR-409-3p/CDK8 axis, suggesting a promising prognostic biomarker and therapeutic target for CC." 1 Circ_0001103 alleviates IL-1beta-induced chondrocyte cell injuries by upregulating SIRT1 via targeting miR-375. hsa_circ_0001103 - circ_0001103 DOID:8398 osteoarthritis Osteoarthritis RT-qPCR down-regulated "Circ_0001103 governed the miR-375/SIRT1 axis to ameliorate IL-1beta-induced chondrocyte injuries, implying that circ_0001103 was a promising biomarker in OA pathogenesis." 1 Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells. hsa_circ_0094342 hsa_circ_PTEN - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "circ-PTEN functions as a tumor-inhibiting circRNA in NSCLC through post-transcriptionally regulating PTEN, hinting a promising diagnostic/prognostic biomarker as well as therapeutic target for NSCLC patients." 1 hsa_circ_0001610 knockdown modulates miR-646-STAT3 axis to suppress endometrial carcinoma progression. hsa_circ_0001610 hsa_circ_TNFRSF21 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated circ_0001610 knockdown represses EC progression through modulating the miR-646-STAT3 axis. 3 Circular RNA hsa_circ_101555 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-145-5p and regulating CDCA3 expression. - - hsa_circ_101555 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circular RNA hsa_circ_101555 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-145-5p and regulating CDCA3 expression. 1 Circ_0114428 Regulates Sepsis-Induced Kidney Injury by Targeting the miR-495-3p/CRBN Axis. hsa_circ_0114428 - circ_0114428 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated "In conclusion, circ_00114428 knockdown attenuated LPS-induced HK2 cell injury by regulating CRBN expression via targeting miR-495-3p." 1 Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer. - hsa_circ_MBOAT2 - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated Circ-MBOAT2 modulated tumor development and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer. This finding suggests that circ-MBOAT2 may be a therapeutic target for pancreatic cancer. 2 CircANKRD11 Knockdown Protects HPMECs from Cigarette Smoke Extract-Induced Injury by Regulating miR-145-5p/BRD4 Axis. - hsa_circ_ANKRD11 circANKRD11 DOID:3083 chronic obstructive pulmonary disease Chronic obstructive pulmonary disease RT-qPCR up-regulated "CircANKRD11 absence protected HPMECs from CSE-induced injury by regulating BRD4 through associating with miR-145-5p, which demonstrated that circANKRD11 had the potential to act as a diagnosis biomarker for smoker-caused COPD." 1 Low Expression of Circular RNA hsa_circ_0078607 Predicts Poor Prognosis in High-Grade Serous Ovarian Cancer. hsa_circ_0078607 hsa_circ_SLC22A3 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated Low expression of circ_0078607 might be an adverse prognostic indicator for HGSOC. 4 Circular RNA CircEPB41L2 Functions as Tumor Suppressor in Hepatocellular Carcinoma Through Sponging miR-590-5p. - hsa_circ_EPB41L2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated Our results suggest that circEPB41L2 might function as a tumor suppressor during HCC progression by sponging miR-590-5p. 1 A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling. hsa_circ_0004872 hsa_circ_MAPK1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Our study revealed that circMAPK1 inhibits the malignant biological behavior of gastric cancer cells through its encoded protein MAPK1-109aa. More importantly, circMAPK1 is a favorable predictor for gastric cancer patients and may provide a new therapeutic target in the treatment of gastric cancer." 2 "circCCDC66 promotes thyroid cancer cell proliferation, migratory and invasive abilities and glycolysis through the miR-211-5p/PDK4 axis." - hsa_circ_CCDC66 - DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "circCCDC66 could promote TC cell proliferation, migratory and invasive abilities and invasion and glycolysis through the miR-211-5p/PDK4 axis." 1 Upregulation of circRNA_100395 sponges miR-142-3p to inhibit gastric cancer progression by targeting the PI3K/AKT axis. - - circRNA_100395 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "These findings also showed that miRNA-142-3p rescued the antitumor effects induced by circRNA_100395-overexpression. cirRNA_100395-overexpression had antitumor effects via regulating the miR-142-3p signaling pathway, which might be a promising treatment target for GC." 1 CircATP5SL promotes infantile haemangiomas progression via IGF1R regulation by targeting miR-873-5p. - hsa_circ_ATP5SL - DOID:178 vascular disease haemangiomas RT-qPCR up-regulated "circATP5SL promotes IH progression by regulating IGF1R expression through adsorption of miR-873-5p, elucidating circATP5SL as a promising therapeutic target for the prognostication and treatment of IH." 1 CircRNA circ_0092314 Induces Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells via Elevating the Expression of S100P by Sponging miR-671. hsa_circ_0092314 - circ_0092314 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "circ_0092314 exerts critical roles in promoting the EMT features of PAAD cells, and provides insight into how elevated expression of circ_0092314 might influence PAAD progression." 1 Circular RNA circ_HECTD1 regulates cell injury after cerebral infarction by miR-27a-3p/FSTL1 axis. - mmu_circ_HECTD1 - DOID:3526 cerebral infarction cerebral infarction RT-qPCR up-regulated "Circ_HECTD1 deficiency could mitigate OGD/R-induced HT22 cell damage by modulating the miR-27a-3p/FSTL1 axis, providing a promising therapeutic target for cerebral infarction treatment." 1 Circ_0093887 upregulates CCND2 and SUCNR1 to inhibit the ox-LDL-induced endothelial dysfunction in atherosclerosis by functioning as a miR-876-3p sponge. hsa_circ_0093887 - Circ_0093887 DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated circ_0093887 protected HAEC against the ox-LDL-induced inflammatory and apoptotic damages by targeting the miR-876-3p/CCND2 or miR-876/SUCNRA axis. Circ_0093887 could act as a potential therapeutic biomarker for AS patients. 2 "Circ-E2F3 acts as a ceRNA for miR-204-5p to promote proliferation, metastasis and apoptosis inhibition in retinoblastoma by regulating ROCK1 expression." - hsa_circ_E2F3 - DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated Circ-E2F3 functioned as a tumor promoter in RB through the miR-204-5p/ROCK1 axis. 1 "Circ_0116061 regulated the proliferation, apoptosis, and inflammation of osteoarthritis chondrocytes through regulating the miR-200b-3p/SMURF2 axis." hsa_circ_0116061 - Circ_0116061 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated circ_0116061 might regulate the miR-200b-3p/SMURF2 axis to promote the progression of OA. 1 Circular RNA hsa-circ-000881 suppresses the progression of lung adenocarcinoma in vitro via a miR-665/PRICKLE2 axis. hsa_circ_000881 - hsa-circ-000881 DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "Circ-000881 has inhibitory effects on LUAD via a miR-665/PRICKLE2 axis, suggesting that circ-000881 may be an underlying therapeutic target for LUAD." 1 Exosomal circ_0004136 enhances the progression of pediatric acute myeloid leukemia depending on the regulation of miR-570-3p/TSPAN3 axis. hsa_circ_0004136 - circ_0004136 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "Our findings identified a novel regulatory mechanism in which exosome-mediated circ_0004136 knockdown restrained AML cell malignant progression at least partly through targeting the miR-570-3p/TSPAN3 axis, highlighting a novel therapeutic strategy for AML management." 2 Circ-OSBPL2 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-193a-5p/BRD4 Axis. - hsa_circ_OSBPL2 - DOID:3083 chronic obstructive pulmonary disease chronic obstructive pulmonary disease RT-qPCR up-regulated "Circ-OSBPL2 contributed to the apoptosis, in fl ammation, and oxidative stress of HBECs in smoke-related COPD by miR-193a-5p/BRD4 axis, suggesting a novel insight on the pathogenesis of COPD and a potential therapeutic strategy for future clinic intervention in COPD." 2 CircRNA circ-OGDH (hsa_circ_0003340) Acts as a ceRNA to Regulate Glutamine Metabolism and Esophageal Squamous Cell Carcinoma Progression by the miR-615-5p/PDX1 Axis. hsa_circ_0003340 hsa_circ_OGDH - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "Circ-OGDH sponged miR-615-5p to elevate PDX1 expression, thus elevating glutamine metabolism and promoting tumor growth in ESCC. The study offered evidence to support circ-OGDH as a promising target for ESCC therapy." 1 "Circ_0001806 Promotes the Proliferation, Migration and Invasion of NSCLC Cells Through miR-1182/NOVA2 Axis." hsa_circ_0001806 - Circ_0001806 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0001806 augments NOVA2 expression by targeting miR-1182 to enhance the multiplication, migration and invasion of NSCLC cells." 1 Circular RNA hsa_circ_0000700 promotes cell proliferation and migration in Esophageal Squamous Cell Carcinoma by sponging miR-1229. hsa_circ_0000700 hsa_circ_CHD9 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated hsa_circ_0000700 functions as an oncogenic factor by sponging miR-1229 in ESCC. 1 Atractylon Treatment Attenuates Pulmonary Fibrosis via Regulation of the mmu_circ_0000981/miR-211-5p/TGFBR2 Axis in an Ovalbumin-Induced Asthma Mouse Model. mmu_circ_0000981 - circRNA-0000981 DOID:3770 pulmonary fibrosis pulmonary fibrosis RT-qPCR up-regulated "Collectively, the findings of the present study suggest that Atr treatment attenuates PF by regulating the mmu_circ_0000981/miR-211-5p/TGFBR2 axis in an OVA-induced asthma mouse model." 1 Circular RNA hsa_circ_0003288 induces EMT and invasion by regulating hsa_circ_0003288/miR-145/PD-L1 axis in hepatocellular carcinoma. hsa_circ_0003288 hsa_circ_BIRC6 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated hsa_circ_0003288 promoted EMT and invasion of HCC via the hsa_circ_0003288/miR-145/PD-L1 axis through the PI3K/Akt pathway. Targeting hsa_circ_0003288 may be a therapeutic strategy for the treatment of HCC. 2 The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway. - hsa_circ_ATP5B - DOID:0060108 brain glioma glioma RT-qPCR up-regulated Our study identified the SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop in GSCs. This provides an effective biomarker for glioma diagnosis and prognostic evaluation. 1 "circ_0003204 Regulates Cell Growth, Oxidative Stress, and Inflammation in ox-LDL-Induced Vascular Endothelial Cells via Regulating miR-942-5p/HDAC9 Axis." hsa_circ_0003204 - circ_0003204 DOID:1936 atherosclerosis Atherosclerosis RT-qPCR down-regulated Circ_0003204 aggravated ox-LDL-induced HUVECs damage via modulating miR-942-5p/HDAC9 pathway. 7 Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma. hsa_circ_0072309 hsa_circ_LIFR - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer microarray up-regulated "hsa_circ_0072309 promotes the proliferation, migration, and invasion of NSCLC cells. In vitro precipitation of circRNAs, luciferase reporter assays, and biotin-coupled microRNA capture assays were carried out to investigate the mechanisms by which hsa_circ_0072309 regulates NSCLC. " 3 hsa_circ_0058357 acts as a ceRNA to promote non_small cell lung cancer progression via the hsa_miR_24_3p/AVL9 axis. hsa_circ_0058357 hsa_circ_ATG9A - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "hsa_circ_0058357 may be a crucial regulation factor in NSCLC by sponging hsa_miR_24_3p, leading to a decrease in miR_24_3p expression, and subsequent increase in AVL9 expression. Therefore, hsa_circ_0058357 may serve as a potential target for diagnosis and gene therapy for NSCLC." 1 circ_LRIG3 contributes to the progression of hepatocellular carcinoma by elevating RNF38 via sponging miR-449a. - hsa_circ_LRIG3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circ_LRIG3 facilitated HCC progression by modulation of miR-449a/LRIG3 axis, which might provide a novel method for HCC therapy." 3 Circ_0055625 knockdown inhibits tumorigenesis and improves radiosensitivity by regulating miR-338-3p/MSI1 axis in colon cancer. hsa_circ_0055625 - Circ_0055625 DOID:219 colon cancer colon cancer RT-qPCR up-regulated Circ_0055625 repression inhibited the progression and radioresistance of colon cancer by downregulating MSI1 through sponging miR-338-3p. This result might provide a theoretical basis for improving the therapy of colon cancer with radiation. 2 "Circ_0006168 Promotes the Migration, Invasion and Proliferation of Esophageal Squamous Cell Carcinoma Cells via miR-516b-5p-Dependent Regulation of XBP1." hsa_circ_0006168 - circ_0006168 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated circ_0006168 contributed to ESCC development through promoting the proliferation and motility of ESCC cells via mediating miR-516b-5p/XBP1 axis. 3 circRNA circFAT1(e2) Elevates the Development of Non-Small-Cell Lung Cancer by Regulating miR-30e-5p and USP22. - hsa_circ_FAT1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circFAT1(e2) gene knockdown could significantly inhibit the proliferation, migration, and invasion of NSCLC cells. Loss of function testing found that circFAT1(e2) functioned as an oncogene in NSCLC cells. In addition, circFAT1(e2) acted as a ceRNA to spongy miR-30e-5p, which led to the increase in USP22 and promoted cell growth. " 1 CircRNA circTRAF3 promotes nasopharyngeal carcinoma metastasis through targeting miR-203a-3p/AKT3 axis. - hsa_circ_TRAF3 - DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, microarray" up-regulated "circTRAF3, which acts as an oncogene in NPC and targets miR-203a-3p/AKT3 pathway. The circTRAF3/miR-203a-3p/AKT3 pathway may be a potential therapeutic target for metastatic NPC." 1 circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p. - hsa_circ_FBXW7 - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated circFBXW7 inhibits proliferation and migration by controlling the miR-942-5p/BARX2 axis in LUAD cell lines and its levels correlates with patient survival suggesting that regulating circFBXW7 could have therapeutic value in treating LUAD patients. 1 CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARalpha/CCL2 pathway. hsa_circ_0110102 - - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "hsa_circ_0110102 acted as a sponge for miR-580-5p and inhibited CCL2 secretion into tumor microenvironment by decrease the expression of PPARalpha in HCC cells, then inhibited the pro-inflammatory cytokine release from macrophages by regulating the COX-2/PGE2 pathway." 1 Circ_0004104 knockdown alleviates oxidized low-density lipoprotein-induced dysfunction in vascular endothelial cells through targeting miR-328-3p/TRIM14 axis in atherosclerosis. hsa_circ_0004104 - circ_0004104 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Circ_0004104 knockdown attenuated ox-LDL-induced dysfunction in HUVECs via miR-328-3p-mediated regulation of TRIM14. 2 Circular RNA circE2F2 promotes malignant progression of ovarian cancer cells by upregulating the expression of E2F2 protein via binding to HuR protein. - hsa_circ_E2F2 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "circE2F2 promoted OC cell proliferation, metastasis, and glucose metabolism by stabilizing the E2F2 mRNA via binding to the HuR protein." 1 Knockdown of circ-UQCRC2 ameliorated lipopolysaccharide-induced injury in MRC-5 cells by the miR-326/PDCD4/NF-kappaB pathway. hsa_circ_0038467 hsa_circ_UQCRC2 circ-UQCRC2 DOID:552 pneumonia pneumonia RT-qPCR up-regulated "Our findings demonstrated a novel regulatory network, the miR-326/PDCD4/NF-¦ĘB pathway, for the function of circ-UQCRC2 in LPS-induced cell injury in MRC-5 cells." 4 Circular RNA hsa_circ_0000117 accelerates the proliferation and invasion of gastric cancer cells by regulating the microRNA-337-3p/signal transducer and activator of transcription 3 axis. hsa_circ_0000117 hsa_circ_MAN1A2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "hsa_circ_0000117 exhibited oncogene properties in combination with the hsa_circ_0000117/miR-337-3p/STAT3 axis in GC, potentially providing a new therapeutic target for GC." 2 "hsa_circ_0001018 promotes papillary thyroid cancer by facilitating cell survival, invasion, G(1)/S cell cycle progression, and repressing cell apoptosis via crosstalk with miR-338-3p and SOX4." hsa_circ_0001018 hsa_circ_CCT4 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated circ_0001018 acted as the tumor promoter via sponging miR-338-3p to elevate SOX4 expression level in PTC. 1 Upregulated hsa_circRNA_100269 inhibits the growth and metastasis of gastric cancer through inactivating PI3K/Akt axis. - - hsa_circRNA_100269 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "our findings indicated that the levels of hsa_circRNA_100269 were reduced in GC. Furthermore, hsa_circRNA_100269 could suppress the development of GC by inactivating the PI3K/Akt pathway. More importantly, hsa_circRNA_100269/PI3K/Akt axis may be a novel therapeutic candidate for GC treatment." 2 CircPVT1 attenuates negative regulation of NRAS by let-7 and drives cancer cells towards oncogenicity. - hsa_circ_PVT1 CircPVT1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "CircPVT1 knockdown significantly reduced NRAS levels and attenuated cancer hallmark phenotypes such as proliferation, migration, resistance to apoptosis, cytoskeletal disorganization, and epithelial-mesenchymal transition. The effects of circPVT1 knockdown were at least partially rescued by blocking binding of let-7 to NRAS 3UTR with a target protector, suggesting that a circPVT1/let-7/NRAS axis exists and acts in cells to reverse NRAS downregulation and favor oncogenicity. " 2 CircPVT1 attenuates negative regulation of NRAS by let-7 and drives cancer cells towards oncogenicity. - hsa_circ_PVT1 CircPVT1 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "CircPVT1 knockdown significantly reduced NRAS levels and attenuated cancer hallmark phenotypes such as proliferation, migration, resistance to apoptosis, cytoskeletal disorganization, and epithelial-mesenchymal transition. The effects of circPVT1 knockdown were at least partially rescued by blocking binding of let-7 to NRAS 3UTR with a target protector, suggesting that a circPVT1/let-7/NRAS axis exists and acts in cells to reverse NRAS downregulation and favor oncogenicity. " 3 Effect of the circCDR1as/miR-641/XIAP regulatory axis on the proliferation and invasion of the prostate cancer PC-3 cell line. - hsa_circ_CDR1 circCDR1as DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "The expression of circCDR1as and XIAP was higher and the expression of miR-641 was lower in the prostate cancer cell lines compared with the normal prostate epithelial cell line. After effectively reducing the expression of circCDR1as and XIAP and increasing the expression of miR-641 in PC-3 cells, the proliferation, invasion and migration of PC-3 cells were effectively inhibited. circCDR1as could bind to miR-641, which targeted the 3-untranslated region of XIAP." 1 Circ_0067835 regulates allergic inflammatory response in type-2 innate lymphoid cells in allergic rhinitis (AR) via miR-155/GATA3. hsa_circ_0067835 hsa_circ_IFT80 - DOID:4481 allergic rhinitis allergic rhinitis RT-qPCR up-regulated silencing circ_0067835 inhibited cytokines and ILC2s levels by down-regulating miR-155. Circ_0067835 effectively inhibited AR response in ILC2s through participation of miR-155/GATA3 axis. 1 "Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/beta-catenin (cyclin D1) axis." - hsa_circ_PSMA1 circPSMA1 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "circPSMA1 functions as a tumor promoter through the circPSMA1/miR-637/Akt1-beta-catenin (cyclin D1) regulatory axis, which can facilitate the tumorigenesis, metastasis, and immunosuppression of TNBC." 1 CircRNA SEPT9 contributes to malignant behaviors of glioma cells via miR-432-5p-mediated regulation of LASP1. - hsa_circ_SEPT9 CircSEPT9 DOID:0060108 brain glioma glioma RT-qPCR up-regulated CircSEPT9 exerted an oncogenic role to enhance the malignant behaviors of glioma cells by binding to miR-432-5p to induce LASP1 expression. 1 Circular RNA circ_0062389 modulates papillary thyroid carcinoma progression via the miR-1179/high mobility group box 1 axis. hsa_circ_0062389 hsa_circ_PI4KA - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "The high expression of circ_0062389 was related to large tumor size and positive lymphatic metastasis. Knocking down circ_0062389 could inhibit the proliferation, migration and EMT process of PTC cells. Besides, miR-1179 was a downstream molecule of circ_0062389." 1 Circ-ZFR Promotes Progression of Bladder Cancer by Upregulating WNT5A Via Sponging miR-545 and miR-1270. - hsa_circ_ZFR - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "CircZFR promotes the proliferation, migration and invasion of BCa cells by upregulating WNT5A signaling pathway via sponging miR-545 and miR-1270." 3 Silencing of circ_0078607 prevents development of gastric cancer and inactivates the ERK1/2/AKT pathway through the miR-188-3p/RAP1B axis. hsa_circ_0078607 hsa_circ_SLC22A3 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Knockdown of circ_0078607 inhibits the proliferation and induces apoptosis of gastric cancer via miR-188-3p/RAP1B signal pathway. 1 CircRASSF2 facilitates the proliferation and metastasis of colorectal cancer by mediating the activity of Wnt/beta-catenin signaling pathway by regulating the miR-195-5p/FZD4 axis. - hsa_circ_RASSF2 CircRASSF2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated that circRASSF2 might function as a tumor promoter to accelerate the progression of CRC via regulating the miR-195-5p/FZD4/Wnt/beta-catenin pathway. 1 "Hsa_circ_0069094 knockdown inhibits cell proliferation, migration, invasion and glycolysis, while induces cell apoptosis by miR-661/HMGA1 axis in breast cancer." hsa_circ_0069094 hsa_circ_S100P - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "hsa_circ_0069094 knockdown repressed breast cancer cell carcinogenesis and cell glycolysis by regulating HMGA1 through sponging miR-661, which provided a new insight for studying the mechanism of hsa_circ_0069094 in modulating breast cancer development." 4 Hsa_circ_0004831 downregulation is partially responsible for atorvastatinalleviated human umbilical vein endothelial cell injuries induced by ox-LDL through targeting the miR-182-5p/CXCL12 axis. hsa_circ_0004831 - - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Hsa_circ_0004831-targeted miR-182-5p/CXCL12 regulatory network is one of the pathways by which ATV protects against ox-LDL-induced endothelial injuries 1 Circular RNA hsa_circ_0091579 facilitates the Warburg effect and malignancy of hepatocellular carcinoma cells via the miR-624/H3F3B axis. hsa_circ_0091579 hsa_circ_GPC3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0091579 accelerated Warburg effect and tumor growth via upregulating H3F3B via adsorbing miR-624 in HCC, providing evidence to support the involvement of circ_0091579 in the progression of HCC." 6 Circ_0023404 sponges miR-136 to induce HK-2 cells injury triggered by hypoxia/reoxygenation via up-regulating IL-6R. hsa_circ_0023404 hsa_circ_RNF121 - DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated circ_0023404 contributed to HK-2 cells injury stimulated by H/R via sponging miR-136 and activating IL-6R. 1 CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR-145/STMN1 axis. - hsa_circ_ZNF609 CircRNA ZNF609 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "circ-ZNF609 promotes cell proliferation, migration, and angiogenesis in NPC by upregulating the expression of STMN1 by sponging miR-145 in NPC." 5 Knockdown of hsa_circ_0134111 alleviates the symptom of osteoarthritis via sponging microRNA-224-5p. hsa_circ_0134111 hsa_circ_PDE1C - DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" up-regulated "circ_PDE1C could target miR-224-5p, and miR-224-5p expressed poorly in knee cartilage tissues from OA patients. Overexpression of miR-224-5p inhibited ECM degradation and apoptosis in chondrocytes. miR-224-5p also targeted CCL2, which activated the JAK2/STAT signaling pathway, thereby promoting cartilage degradation and exacerbating the symptoms of OA patients." 2 Circ_0017956 promotes the proliferation and metastasis of non-small cell lung cancer through regulating miR-515-5p/ITGB8 axis. hsa_circ_0017956 hsa_circ_MLLT10 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0017956 could promote NSCLC carcinogenesis at least partly through sponging miR-515-5p and upregulating ITGB8 level, providing a novel theoretical basis for NSCLC treatment." 2 Circ_ZFP644 attenuates caerulein-induced inflammatory injury in rat pancreatic acinar cells by modulating miR-106b/Pias3 axis. - hsa_circ_ZFP644 circ_ZFP644 DOID:2913 acute pancreatitis acute pancreatitis RT-qPCR down-regulated Circ_ZFP644 might exert its anti-inflammation and pro-apoptosis roles in caerulein-induced AR42J cells by regulating miR-106b/Pias3 axis. 1 "CircEHD2, CircNETO2 and CircEGLN3 as Diagnostic and Prognostic Biomarkers for Patients with Renal Cell Carcinoma." - hsa_circ_EHD2 CircEHD2 DOID:4450 renal cell carcinoma renal cell carcinoma "RT-qPCR, microarray" up-regulated "circEHD2, circENGLN3, and circNETO2 were upregulated in ccRCC compared with non-malignant renal tissue. circENGLN3 expression was highly discriminative between normal and cancerous tissue." 2 "CircEHD2, CircNETO2 and CircEGLN3 as Diagnostic and Prognostic Biomarkers for Patients with Renal Cell Carcinoma." - hsa_circ_NETO2 CircNETO2 DOID:4450 renal cell carcinoma renal cell carcinoma "RT-qPCR, microarray" up-regulated "circEHD2, circENGLN3, and circNETO2 were upregulated in ccRCC compared with non-malignant renal tissue. circENGLN3 expression was highly discriminative between normal and cancerous tissue." 1 "CircEHD2, CircNETO2 and CircEGLN3 as Diagnostic and Prognostic Biomarkers for Patients with Renal Cell Carcinoma." - hsa_circ_ENGLN3 circENGLN3 DOID:4450 renal cell carcinoma renal cell carcinoma "RT-qPCR, microarray" up-regulated "circEHD2, circENGLN3, and circNETO2 were upregulated in ccRCC compared with non-malignant renal tissue. circENGLN3 expression was highly discriminative between normal and cancerous tissue." 1 Regulation of MRP4 Expression by circHIPK3 via Sponging miR-124-3p/miR-4524-5p in Hepatocellular Carcinoma. - hsa_circ_HIPK3 circHIPK3 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated miR-4524-5p downregulates the expression of MRP4 and circHIPK3 regulates MRP4 expression by sponging miR-124-3p and miR-4524-5p for the first time. 6 Circular RNA hsa_circ_0006401 promotes proliferation and metastasis in colorectal carcinoma. hsa_circ_0006401 hsa_circ_col6a3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circRNAs generated from col6a3 that contain an open-reading frame (ORF) encode a novel 198-aa functional peptide and hsa_circ_0006401 peptides promote stability of the host gene col6a3 mRNA to promote CRC proliferation and metastasis. 1 CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. hsa_circ_0008305 hsa_circ_PTK2 circPTK2 DOID:0040085 bacterial sepsis sepsis RT-qPCR up-regulated Our research reveals that circPTK2 regulates microglia activation and hippocampal neuronal apoptosis induced by sepsis via miR-181c-5p-HMGB1 signaling. 1 Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer. - - circRNA_102481 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer microarray up-regulated tumor-derived exosomal circRNA_ 102481 could contribute to EGFR-TKIs resistance via the microRNA-30a-5p/ROR1 axis in NSCLC. 1 TCEB3 is Regulated by Circ-0000212/miR-140-3p Axis to Promote the Progression of Cervical Cancer. hsa_circ_0000212 - Circ-0000212 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Silencing of TCEB3 attenuated cell proliferation and invasion and promoted apoptosis of cervical cancer cells, and this effect was regulated by circ-0000212/miR-140-3p axis." 3 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0000691 hsa_circ_ZNF646 - DOID:8577 ulcerative colitis ulcerative colitis microarray up-regulated "The top 10 upregulated circRNAs in CD compared with HC were hsa_circ_0000691, hsa_circ_0001666, hsa_circ_0004183, hsa_circ_0009024, hsa_circ RNA_405324, hsa_circ_0002003, hsa_circ_0085323, hsa_circ_0040994, hsa_circ_0062142, and hsa_circ_0048148." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0001666 hsa_circ_FAM120B - DOID:8577 ulcerative colitis ulcerative colitis microarray up-regulated "The top 10 upregulated circRNAs in CD compared with HC were hsa_circ_0000691, hsa_circ_0001666, hsa_circ_0004183, hsa_circ_0009024, hsa_circ RNA_405324, hsa_circ_0002003, hsa_circ_0085323, hsa_circ_0040994, hsa_circ_0062142, and hsa_circ_0048149." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0004183 hsa_circ_FRMD4A - DOID:8577 ulcerative colitis ulcerative colitis microarray up-regulated "The top 10 upregulated circRNAs in CD compared with HC were hsa_circ_0000691, hsa_circ_0001666, hsa_circ_0004183, hsa_circ_0009024, hsa_circ RNA_405324, hsa_circ_0002003, hsa_circ_0085323, hsa_circ_0040994, hsa_circ_0062142, and hsa_circ_0048150." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0009024 hsa_circ_TXLNG2P - DOID:8577 ulcerative colitis ulcerative colitis microarray up-regulated "The top 10 upregulated circRNAs in CD compared with HC were hsa_circ_0000691, hsa_circ_0001666, hsa_circ_0004183, hsa_circ_0009024, hsa_circ RNA_405324, hsa_circ_0002003, hsa_circ_0085323, hsa_circ_0040994, hsa_circ_0062142, and hsa_circ_0048151." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. - - hsa_circ RNA_405324 DOID:8577 ulcerative colitis ulcerative colitis microarray up-regulated "The top 10 upregulated circRNAs in CD compared with HC were hsa_circ_0000691, hsa_circ_0001666, hsa_circ_0004183, hsa_circ_0009024, hsa_circ RNA_405324, hsa_circ_0002003, hsa_circ_0085323, hsa_circ_0040994, hsa_circ_0062142, and hsa_circ_0048152." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0002003 hsa_circ_KIAA0146 - DOID:8577 ulcerative colitis ulcerative colitis microarray up-regulated "The top 10 upregulated circRNAs in CD compared with HC were hsa_circ_0000691, hsa_circ_0001666, hsa_circ_0004183, hsa_circ_0009024, hsa_circ RNA_405324, hsa_circ_0002003, hsa_circ_0085323, hsa_circ_0040994, hsa_circ_0062142, and hsa_circ_0048153." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0085323 hsa_circ_EIF3E - DOID:8577 ulcerative colitis ulcerative colitis microarray up-regulated "The top 10 upregulated circRNAs in CD compared with HC were hsa_circ_0000691, hsa_circ_0001666, hsa_circ_0004183, hsa_circ_0009024, hsa_circ RNA_405324, hsa_circ_0002003, hsa_circ_0085323, hsa_circ_0040994, hsa_circ_0062142, and hsa_circ_0048154." 2 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0040994 hsa_circ_FANCA - DOID:8577 ulcerative colitis ulcerative colitis microarray up-regulated "The top 10 upregulated circRNAs in CD compared with HC were hsa_circ_0000691, hsa_circ_0001666, hsa_circ_0004183, hsa_circ_0009024, hsa_circ RNA_405324, hsa_circ_0002003, hsa_circ_0085323, hsa_circ_0040994, hsa_circ_0062142, and hsa_circ_0048155." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0062142 hsa_circ_psiTPTE22 - DOID:8577 ulcerative colitis ulcerative colitis microarray up-regulated "The top 10 upregulated circRNAs in CD compared with HC were hsa_circ_0000691, hsa_circ_0001666, hsa_circ_0004183, hsa_circ_0009024, hsa_circ RNA_405324, hsa_circ_0002003, hsa_circ_0085323, hsa_circ_0040994, hsa_circ_0062142, and hsa_circ_0048156." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0048148 hsa_circ_CNN2 - DOID:8577 ulcerative colitis ulcerative colitis microarray up-regulated "The top 10 upregulated circRNAs in CD compared with HC were hsa_circ_0000691, hsa_circ_0001666, hsa_circ_0004183, hsa_circ_0009024, hsa_circ RNA_405324, hsa_circ_0002003, hsa_circ_0085323, hsa_circ_0040994, hsa_circ_0062142, and hsa_circ_0048157." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0049356 hsa_circ_CARM1 - DOID:8577 ulcerative colitis ulcerative colitis microarray down-regulated "the top 10 downregulated circRNAs were hsa_circ_0049356, hsa_circ RNA_405443, hsa_circ RNA_403556, hsa_circ_0092328, hsa_circ_0003979, hsa_circ_0074491, hsa_circ_0023461, hsa_circ RNA_406237, hsa_circ_0034044, and hsa_circ RNA_400564." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. - - hsa_circ RNA_405443 DOID:8577 ulcerative colitis ulcerative colitis microarray down-regulated "the top 10 downregulated circRNAs were hsa_circ_0049356, hsa_circ RNA_405443, hsa_circ RNA_403556, hsa_circ_0092328, hsa_circ_0003979, hsa_circ_0074491, hsa_circ_0023461, hsa_circ RNA_406237, hsa_circ_0034044, and hsa_circ RNA_400565." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. - - hsa_circ RNA_403556 DOID:8577 ulcerative colitis ulcerative colitis microarray down-regulated "the top 10 downregulated circRNAs were hsa_circ_0049356, hsa_circ RNA_405443, hsa_circ RNA_403556, hsa_circ_0092328, hsa_circ_0003979, hsa_circ_0074491, hsa_circ_0023461, hsa_circ RNA_406237, hsa_circ_0034044, and hsa_circ RNA_400566." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0092328 hsa_circ_SNORD24 - DOID:8577 ulcerative colitis ulcerative colitis microarray down-regulated "the top 10 downregulated circRNAs were hsa_circ_0049356, hsa_circ RNA_405443, hsa_circ RNA_403556, hsa_circ_0092328, hsa_circ_0003979, hsa_circ_0074491, hsa_circ_0023461, hsa_circ RNA_406237, hsa_circ_0034044, and hsa_circ RNA_400567." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0003979 hsa_circ_FAM210A - DOID:8577 ulcerative colitis ulcerative colitis microarray down-regulated "the top 10 downregulated circRNAs were hsa_circ_0049356, hsa_circ RNA_405443, hsa_circ RNA_403556, hsa_circ_0092328, hsa_circ_0003979, hsa_circ_0074491, hsa_circ_0023461, hsa_circ RNA_406237, hsa_circ_0034044, and hsa_circ RNA_400568." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0074491 hsa_circ_PPARGC1B - DOID:8577 ulcerative colitis ulcerative colitis microarray down-regulated "the top 10 downregulated circRNAs were hsa_circ_0049356, hsa_circ RNA_405443, hsa_circ RNA_403556, hsa_circ_0092328, hsa_circ_0003979, hsa_circ_0074491, hsa_circ_0023461, hsa_circ RNA_406237, hsa_circ_0034044, and hsa_circ RNA_400569." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0023461 hsa_circ_ARAP1 - DOID:8577 ulcerative colitis ulcerative colitis microarray down-regulated "the top 10 downregulated circRNAs were hsa_circ_0049356, hsa_circ RNA_405443, hsa_circ RNA_403556, hsa_circ_0092328, hsa_circ_0003979, hsa_circ_0074491, hsa_circ_0023461, hsa_circ RNA_406237, hsa_circ_0034044, and hsa_circ RNA_400570." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. - - hsa_circ RNA_406237 DOID:8577 ulcerative colitis ulcerative colitis microarray down-regulated "the top 10 downregulated circRNAs were hsa_circ_0049356, hsa_circ RNA_405443, hsa_circ RNA_403556, hsa_circ_0092328, hsa_circ_0003979, hsa_circ_0074491, hsa_circ_0023461, hsa_circ RNA_406237, hsa_circ_0034044, and hsa_circ RNA_400571." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. hsa_circ_0034044 hsa_circ_HERC2P3 - DOID:8577 ulcerative colitis ulcerative colitis microarray down-regulated "the top 10 downregulated circRNAs were hsa_circ_0049356, hsa_circ RNA_405443, hsa_circ RNA_403556, hsa_circ_0092328, hsa_circ_0003979, hsa_circ_0074491, hsa_circ_0023461, hsa_circ RNA_406237, hsa_circ_0034044, and hsa_circ RNA_400572." 1 Expression profiles of circular RNAs in colon biopsies from Crohn disease patients by microarray analysis. - - hsa_circ RNA_400564 DOID:8577 ulcerative colitis ulcerative colitis microarray down-regulated "the top 10 downregulated circRNAs were hsa_circ_0049356, hsa_circ RNA_405443, hsa_circ RNA_403556, hsa_circ_0092328, hsa_circ_0003979, hsa_circ_0074491, hsa_circ_0023461, hsa_circ RNA_406237, hsa_circ_0034044, and hsa_circ RNA_400573." 1 Identification of an immune signature to predict poor clinical outcome in cervical cancer. hsa_circ_0025721 hsa_circ_ARNTL2 - DOID:4362 cervical cancer cervical cancer RNA-seq up-regulated "CXCL8 could distinguish normal tissue, low- and high-risk tumor tissues, the expression of which showed an increasing trend among the three groups. RNA-seq and bioinformatics indicated that circRNAs like hsa_circ_0025721 might upregulate CXCL8 through sponging miRNAs including hsa-miR-4428." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_103899 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq up-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 3 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_104700 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq up-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 4 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_101286 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq up-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 5 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_104161 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq up-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 6 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_000368 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq up-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 7 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_000689 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq up-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 8 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_104592 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq up-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 9 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_104103 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq up-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 10 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_102315 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq up-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 11 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_103642 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq up-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 12 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_101128 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq up-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 13 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_101182 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq down-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 14 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_103494 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq down-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 15 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. - - hsa_circRNA_103801 DOID:11394 adult respiratory distress syndrome sepsis induced acute respiratory distress syndrome RNA-seq down-regulated "Combining the previous sequencing results in the plasma of ARDS patients, 11 up-regulated and 16 down-regulated circRNAs simultaneously in plasma and lung tissues were identified." 1 circ_NRIP1 is oncogenic in malignant development of esophageal squamous cell carcinoma (ESCC) via miR-595/SEMA4D axis and PI3K/AKT pathway. - hsa_circ_NRIP1 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "circ_NRIP1 functioned as an oncogene in ESCC, and modulated ESCC cell growth, migration and invasion both in vitro and in vivo via targeting miR-595/SEMA4D axis and inhibiting PI3K/AKT signaling pathway." 2 Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells by sponging miR-1270 to activate the NF-kappaB signaling pathway. - - ciRS-7 DOID:1733 cryptosporidiosis cryptosporidiosis RT-qPCR up-regulated "Our results revealed that ciRS-7 would promote C. parvum propagation by regulating the miR-1270/relA axis and affecting the NF-kappaB pathway. To the best of our knowledge, this is the first study to investigate the role of circRNA during Cryptosporidium infection, and the findings provide a novel view for implementing control strategies against Cryptosporidium infection." 1 "Knockdown of Circ_0000144 Suppresses Cell Proliferation, Migration and Invasion in Gastric Cancer Via Sponging MiR-217." hsa_circ_0000144 - Circ_0000144 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circ_0000144 inhibition suppresses GC cell proliferation, migration and invasion via absorbing miR-217, providing a new biomarker and potential therapeutic target for treatment of GC." 3 CircSLC7A2 protects against osteoarthritis through inhibition of the miR-4498/TIMP3 axis. - hsa_circ_SLC7A2 CircSLC7A2 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "Loss of circSLC7A2 reduced the sponge of miR-4498 and further inhibited the expression of TIMP3, subsequently leading to an inflammatory response. We further determined that miR-4498 inhibitor reversed circSLC7A2-knockdown-induced OA phenotypes." 1 Blocking circ-CNST suppresses malignant behaviors of osteosarcoma cells and inhibits glycolysis through circ-CNST-miR-578-LDHA/PDK1 ceRNA networks. - hsa_circ_CNST circ-CNST DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circ-CNST knockdown could antagonize malignant behaviors and glycolysis of OS cells by regulating miR-578-LDHA/PDK1 axes. 2 CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis. - hsa_circ_ASH2L CircASH2L DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "CircASH2L promoted RA-FLS growth, motility, and inflammation through miR-129-5p/HIPK2 axis." 3 Gastric cancer derived exosomes mediate the delivery of circRNA to promote angiogenesis by targeting miR-29a/VEGF axis in endothelial cells. hsa_circ_0044366 hsa_circ_ATP5G1 circ29 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "circ29, as a sponge of miR-29a, plays a responsible role in the occurrence and development of GC by regulating the VEGF pathway." 1 Circular RNA UBAP2 promotes the proliferation of prostate cancer cells via the miR-1244/MAP3K2 axis. - hsa_circ_UBAP2 CircUBAP2 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated circUBAP2 promoted the proliferation of PCa cells by sponging miR-1244 and promoting the MAP3K2 axis. 1 "Higher circular RNA_0015278 correlates with absence of extrathyroidal invasion, lower pathological tumor stages, and prolonged disease-free survival in papillary thyroid carcinoma patients." hsa_circ_0015278 - circ_0015278 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" down-regulated "Circ_0015278 is reduced in tumor tissues, while its higher expression in tumor correlates with absence of extrathyroidal invasion, lower pT, pN, and pTNM stage, as well as prolonged DFS in PTC patients." 2 "Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p/GRB10 axis." hsa_circ_0009910 - Circ_0009910 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "circ_0009910-containing exosomes mediated proliferation, apoptosis and cell cycle progression of AML cells partially through miR-5195-3p/GRB10 axis." 3 "Exosomal circ_0030167 derived from BM-MSCs inhibits the invasion, migration, proliferation and stemness of pancreatic cancer cells by sponging miR-338-5p and targeting the Wif1/Wnt8/beta-catenin axis." hsa_circ_0030167 - circ_0030167 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR dysregulated BM-MSC exosomal circ_0030167 contributes to the progression and stemness of PC cells via the miR-338-5p/wif1/Wnt 8/beta-catenin axis. 1 CircATRNL1 protects against osteoarthritis by targeting miR-153-3p and KLF5. - hsa_circ_ATRNL1 CircATRNL1 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" down-regulated circATRNL1 might ameliorate the development and progression of OA through regulating miR-153-3p/KLF5 axis. 2 CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis. - - CircRNA_30032 DOID:0050855 renal fibrosis renal fibrosis RT-qPCR up-regulated circRNA_30032 promotes renal fibrosis via the miR-96-5p/HBEGF/KRAS axis and suggest that circRNA_30032 is a potential therapeutic target for treatment of renal fibrosis. 1 Hsa Circ 001839 Promoted Inflammation in Renal Ischemia-Reperfusion Injury Through NLRP3 by miR-432-3p. - - circ_001839 DOID:326 ischemia renal ischemia-reperfusion injury RT-qPCR up-regulated These findings suggested that circ 001839 promoted inflammation in RI-RI through NLRP3 by miR-432-3p. 1 Circular RNA circ_0128846 promotes the progression of osteoarthritis by regulating miR-127-5p/NAMPT axis. hsa_circ_0128846 hsa_circ_ZFR - DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Circ_0128846 knockdown might inhibit the progression of OA by upregulating miR-127-5p and downregulating NAMPT. 2 Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma. hsa_circ_0072083 hsa_circ_ZFR - DOID:0060108 brain glioma glioma RT-qPCR up-regulated Exosomal circ_0072083 promoted TMZ resistance via increasing NANOG via regulating miR-1252-5p-mediated degradation and demethylation in glioma. 1 CircRNA_2646 functions as a ceRNA to promote progression of esophageal squamous cell carcinoma via inhibiting miR-124/PLP2 signaling pathway. - - CircRNA_2646 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated CircRNA_2646 functioned as an inhibitor in miR-124 signaling pathway in ESCC for carcinogenesis and could be a promising target for ESCC therapy. 1 "hsa_circ_0062019 promotes the proliferation, migration, and invasion of prostate cancer cells via the miR-195-5p/HMGA2 axis." hsa_circ_0062019 hsa_circ_SLC19A1 - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "hsa_circ_0062019 promoted cancer cell proliferation, migration, and invasion through targeting miR-195-5p/HMGA2." 3 Silencing circANKRD36 inhibits streptozotocin-induced insulin resistance and inflammation in diabetic rats by targeting miR-145 via XBP1. - rno_circ_ANKRD36 circANKRD36 DOID:9352 type 2 diabetes mellitus insulin resistance RT-qPCR up-regulated Silencing circANKRD36 inhibits streptozotocin-induced insulin resistance and inflammation in diabetic rats by targeting miR-145 via XBP1. 1 Knockdown of circBFAR inhibits proliferation and glycolysis in gastric cancer by sponging miR-513a-3p/hexokinase 2 axis. - hsa_circ_BFAR circBFAR DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated we found a circBFAR/miR-513a-3p/HK2 axis in GC and revealed the relationship between circBFAR and glycolysis for the first time. circBFAR may serve as a novel target of GC individualized therapy. 1 Circular RNA circFADS2 is overexpressed in sepsis and suppresses LPS-induced lung cell apoptosis by inhibiting the maturation of miR-15a-5p. - hsa_circ_FADS2 circFADS2 DOID:0040085 bacterial sepsis sepsis RT-qPCR up-regulated CircFADS2 is upregulated in sepsis to suppress LPS-induced lung cell apoptosis by inhibiting miR-15a-5p maturation. 2 "Circular RNA circ_0000712 regulates high glucose-induced apoptosis, inflammation, oxidative stress, and fibrosis in (DN) by targeting the miR-879-5p/SOX6 axis." hsa_circ_0000712 hsa_circ_NFATC3 - DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "Circ_0000712 knockdown could hinder HG-inducted SV40-MES13 cell injury through targeting the miR-879-5p/SOX6 axis, implying a possible circRNA-targeted therapy for DN." 1 CircRNA circ_POLA2 is Upregulated in Acute Myeloid Leukemia (AML) and Promotes Cell Proliferation by Suppressing the Production of Mature miR-34a. - hsa_circ_POLA2 - DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated Circ_POLA2 is upregulated in AML and promotes cell proliferation by suppressing the production of mature miR-34a. 1 Circular RNA circUbe2k promotes hepatic fibrosis via sponging miR-149-5p/TGF-beta2 axis. - hsa_circ_Ube2k circUbe2k DOID:409 liver disease hepatic fibrosis RT-qPCR up-regulated circUbe2k may act as a catalyst of HSCs activation and HF through the circUbe2k/miR-149-5p/TGF-beta2 axis. 1 Exosomal circRNA 0001445 promotes glioma progression through miRNA-127-5p/SNX5 pathway. hsa_circ_0001445 hsa_circ_SMARCA5 circ_0001445 DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" up-regulated exosomal circRNA 0001445 promoted glioma progression through miRNA-127-5p/SNX5 signaling pathway. 1 Overexpression of hsa_circ_0001445 reverses oxLDL_induced inhibition of HUVEC proliferation via SRSF1. hsa_circ_0001445 hsa_circ_SMARCA5 circRNA cSMARCA5 DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated overexpression of hsa_circ_0001445 reversed oxLDL_induced inhibition of HUVEC proliferation via activation of the SRSF1/beta_catenin axis. These findings may provide novel targets for the treatment of atherosclerosis. 1 CircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity. - hsa_circ_MEMO1 CircMEMO1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "circMEMO1 can modulate the promoter methylation and gene expression of TCF21 to regulate HCC progression by acting as a sponge for miR-106b-5p, which targets the TET family of genes and increases the 5hmC level. More importantly, circMEMO1 can increase the sensitivity of HCC cells to sorafenib treatment." 1 Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression. hsa_circ_0071542 hsa_circ_ACSL1 circACSL1 DOID:820 myocarditis myocarditis RT-qPCR up-regulated "circACSL1 could aggravate myocardial inflammation and myocardial injury through competitive absorption of miR-8055, thereby upregulating MAPK14 expression." 1 The circular RNA circ_GRHPR promotes NSCLC cell proliferation and invasion via interactions with the RNA-binding protein PCBP2. - hsa_circ_GRHPR - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated four-and-a-half LIM-only protein 3 (FHL3) is a tumour-stimulating factor in NSCLC that interacts with and is influenced by PCBP2. Circ_GRHPR increased FHL3 expression in the nucleus of NSCLC cells by decreasing PCBP2 expression therein and promoting the proliferation and invasion of NSCLC cells. 1 CircMKLN1 Suppresses the Progression of Human Retinoblastoma by Modulation of miR-425-5p/PDCD4 Axis. - hsa_circ_MKLN1 CircMKLN1 DOID:768 retinoblastoma Retinoblastoma RT-qPCR down-regulated CircMKLN1 overexpression decelerated the progression of RB through sponging miR-425-5p and elevating PDCD4. 1 CircAMD1 regulates proliferation and collagen synthesis via sponging miR-27a-3p in P63-mutant human dermal fibroblasts. - hsa_circ_AMD1 circAMD1 DOID:37 skin disease skin "RT-qPCR, microarray" down-regulated "Collectively, our data show that circAMD1 functions as a miR-27a-3p sponge that inhibits the functional and phenotypical alteration of P63-mutant HDFs and may be a critical marker in pathogenesis regarding P63-associated traits." 1 Circ-EGFR Functions as an Inhibitory Factor in the Malignant Progression of Glioma by Regulating the miR-183-5p/TUSC2 Axis. hsa_circ_0080223 hsa_circ_EGFR circ-EGFR DOID:0060108 brain glioma glioma RT-qPCR down-regulated circ-EGFR inhibited the malignant progression of glioma by regulating the levels of miR-183-5p and TUSC2. 2 Knockdown circular RNA circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a. - hsa_circ_GFRA1 circGFRA1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated knockdown circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a. 1 Hsa_circ_0010220 regulates miR-198/Syntaxin 6 axis to promote osteosarcoma progression. hsa_circ_0010220 hsa_circ_ARHGEF10L circ_0010220 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ_0010220 contributes to osteosarcoma progression through mediating miR-198/STX6 axis, which might be a novel therapeutic target for osteosarcoma therapy." 3 circDENND1B Participates in the Antiatherosclerotic Effect of IL-1beta Monoclonal Antibody in Mouse by Promoting Cholesterol Efflux via miR-17-5p/Abca1 Axis. mmu_circ_0000081 mmu_circ_DENND1B circDENND1B DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Our study revealed that circDENND1B, a novel regulator of cholesterol efflux, is a potential therapeutic target in atherosclerosis and provides new insights into the interaction between inflammation and cholesterol transport." 1 Circular RNA circHECTD1 prevents Diosbulbin-B-sensitivity via miR-137/PBX3 axis in gastric cancer. hsa_circ_0031452 hsa_circ_HECTD1 circHECTD1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated the deletion of PBX3 reversed the impact of miR-137 repression and circHECTD1 knockdown on DB-sensitivity in vitro. 2 Circular RNA circ_0008274 upregulates granulin to promote the progression of hepatocellular carcinoma via sponging microRNA -140-3p. hsa_circ_0008274 hsa_circ_UGGT2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circular RNA circ_0008274 upregulates granulin to promote the progression of hepatocellular carcinoma via sponging microRNA -140-3p. 2 Depletion of Circular RNA circ_CORO1C Suppresses Gastric Cancer Development by Modulating miR-138-5p/KLF12 Axis. - hsa_circ_CORO1C - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Depletion of circ_CORO1C suppressed GC progression by regulating miR-138-5p/KLF12 axis, offering a potential molecular target for GC therapy." 2 "Circ_HIPK3 Knockdown Inhibits Cell Proliferation, Migration and Invasion of Cholangiocarcinoma Partly via Mediating the miR-148a-3p/ULK1 Pathway." - hsa_circ_HIPK3 - DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR up-regulated Circ_HIPK3 knockdown blocked CCA malignant development partly via regulating the miR-148a-3p/ULK1 pathway. 2 Circular RNAs hsa-circ0000175 and hsa-circ0044235 in plasma are novel biomarkers for new-onset rheumatoid arthritis. hsa_circ_0000175 hsa_circ_ELK4 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "hsa-circ0000175 was significantly elevated in plasma from patients with new-onset RA compared with HC and patients with new-onset SLE, but significantly was reduced when compared with OA + UA patients. Hsa-circ0044235 was found to be significantly decreased in plasma from patients with new-onset RA compared with HC and OA + UA patients, but was significantly increased compared with SLE patients." 2 Circular RNAs hsa-circ0000175 and hsa-circ0044235 in plasma are novel biomarkers for new-onset rheumatoid arthritis. hsa_circ_0044235 hsa_circ_CDC27 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR down-regulated "hsa-circ0000175 was significantly elevated in plasma from patients with new-onset RA compared with HC and patients with new-onset SLE, but significantly was reduced when compared with OA + UA patients. Hsa-circ0044235 was found to be significantly decreased in plasma from patients with new-onset RA compared with HC and OA + UA patients, but was significantly increased compared with SLE patients." 3 Inhibition of circRNA circVPS33B Reduces Warburg Effect and Tumor Growth Through Regulating the miR-873-5p/HNRNPK Axis in Infiltrative Gastric Cancer. - hsa_circ_VPS33B circVPS33B DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "CircVPS33B accelerated Warburg effect and tumor growth through regulating the miR-873-5p/HNRNPK axis in infiltrative GC, manifesting that circVPS33B might be a potential target for infiltrative GC treatment." 3 CircHIPK2 Contributes to DDP Resistance and Malignant Behaviors of DDP-Resistant Ovarian Cancer Cells Both in vitro and in vivo Through circHIPK2/miR-338-3p/CHTOP ceRNA Pathway. - hsa_circ_HIPK2 CircHIPK2 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated CircHIPK2 might be a tumor promoter in OvCa and was associated with DDP resistance. Silencing circHIPK2 might suppress DDP-resistant OvCa through regulating miR-338-3p/CHTOP axis. 3 Circular RNA Circ0021205 Promotes Cholangiocarcinoma Progression Through MiR-204-5p/RAB22A Axis. hsa_circ_0021205 hsa_circ_WEE1 circ0021205 DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR up-regulated Circular RNA Circ0021205 Promotes Cholangiocarcinoma Progression Through MiR-204-5p/RAB22A. 1 circAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1alpha level. - hsa_circ_AGFG1 circAGFG1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circAGFG1 promoted the proliferation, migration, and invasion and suppressed the apoptosis of NSCLC cells through accelerating the glycolysis via miR-28-5p/HIF-1alpha axis." 2 Circular RNA ITCH promotes extracellular matrix degradation via activating Wnt/beta-catenin signaling in intervertebral disc degeneration. - hsa_circ_ITCH CircITCH DOID:90 degenerative disc disease intervertebral disc degeneration RT-qPCR up-regulated circITCH promotes ECM degradation in IDD by activating Wnt/beta-catenin through miR-17-5p/SOX4 signaling. 1 Circular RNA ABCB10 contributes to laryngeal squamous cell carcinoma (LSCC) progression by modulating the miR-588/CXCR4 axis. - hsa_circ_ABCB10 circABCB10 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR dysregulated circABCB10 was involved in the malignant progression of LSCC by regulating miR-588/CXCR4 axis. 1 FMR1/circCHAF1A/miR-211-5p/HOXC8 feedback loop regulates proliferation and tumorigenesis via MDM2-dependent p53 signaling in GSCs. - hsa_circ_CHAF1A circCHAF1A DOID:0060108 brain glioma glioma RT-qPCR up-regulated FMR1/circCHAF1A/miR-211-5p/HOXC8 feedback loop regulates proliferation and tumorigenesis via MDM2-dependent p53 signaling in GSCs. 1 Downregulation of circ_0037655 impedes glioma formation and metastasis via the regulation of miR-1229-3p/ITGB8 axis. hsa_circ_0037655 - circ_0037655 DOID:0060108 brain glioma glioma RT-qPCR up-regulated downregulation of the expression of circ_0037655 could inhibit glioma progression by acting on the miR-1229-3p/ITGB8 axis. 2 "Dysregulated circ_0004913, circ_0008160, circ_0000517, and their potential as biomarkers for disease monitoring and prognosis in hepatocellular carcinoma." hsa_circ_0004913 - circ_0004913 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Circ_0004913 (p < 0.001) and circ_0008160 (p < 0.001) were downregulated, while circ_0000517 (p < 0.001) was upregulated in tumor tissue compared with paired adjacent tissue." 3 "Dysregulated circ_0004913, circ_0008160, circ_0000517, and their potential as biomarkers for disease monitoring and prognosis in hepatocellular carcinoma." hsa_circ_0008160 - circ_0008160 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Circ_0004913 (p < 0.001) and circ_0008160 (p < 0.001) were downregulated, while circ_0000517 (p < 0.001) was upregulated in tumor tissue compared with paired adjacent tissue." 1 "Dysregulated circ_0004913, circ_0008160, circ_0000517, and their potential as biomarkers for disease monitoring and prognosis in hepatocellular carcinoma." hsa_circ_0000517 - circ_0000517 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0004913 (p < 0.001) and circ_0008160 (p < 0.001) were downregulated, while circ_0000517 (p < 0.001) was upregulated in tumor tissue compared with paired adjacent tissue." 5 Circ_0000745 strengthens the expression of CCND1 by functioning as miR-488 sponge and interacting with HuR binding protein to facilitate the development of oral squamous cell carcinoma. hsa_circ_0000745 - Circ_0000745 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Circ_0000745 regulated the expression of CCND1 partly by acting as miR-488 sponge and interacting with HuR protein, thus promoting the progression of OSCC." 1 "Circular RNA_0001495 increases Robo1 expression by sponging microRNA-527 to promote the proliferation, migration and invasion of bladder cancer cells." hsa_circ_0001495 hsa_circ_CCNB1 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circ_0001495 was found to promote the proliferation, migration and invasion of BCa cells in vitro through the miR-527/Robo1 axis and promote the growth and metastasis of BCa tumors in vivo." 1 "Circ_0038467 regulates lipopolysaccharide-mediated cell proliferation, apoptosis, and inflammatory response by miR-195-5p/TLR4 axis through NF-kappaB pathway in MRC-5 cells." hsa_circ_0038467 - circ_0038467 DOID:552 pneumonia pneumonia RT-qPCR up-regulated "Circ_0038467 silencing protected MRC-5 cells from LPS-induced injury by miR-195-5p/TLR4 axis through NF-¦ĘB pathway, providing a theoretical basis for circRNA-directed IP therapy." 4 "Circ_0001955 Acts as a miR-646 Sponge to Promote the Proliferation, Metastasis and Angiogenesis of Hepatocellular Carcinoma." hsa_circ_0001955 - Circ_0001955 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circ_0001955 might play a positive role in HCC progression via regulating the miR-646/FZD4 axis, indicating that circ_0001955 might be a potential therapeutic target for HCC." 5 Exosomal circEPB41L2 serves as a sponge for miR-21-5p and miR-942-5p to suppress colorectal cancer progression by regulating the PTEN/AKT signalling pathway. - hsa_circ_EPB41L2 circEPB41L2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Overexpressed circEPB41L2 inhibited colorectal cancer cell proliferation, migration, invasion and promoted apoptosis, as well as suppressed the activity of PTEN/AKT signalling pathway. CircEPB41L2 could sponge miR-21-5p or miR-942-5p. MiR-21-5p or miR-942-5p could reverse the inhibition effect of circEPB41L2 on colorectal cancer progression and PTEN/AKT signalling pathway." 1 Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis. hsa_circ_0006168 hsa_circ_CNOT6L - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "Circ_0006168 facilitated Taxol resistance in ESCC by regulating miR-194-5p/JMJD1C axis, providing a promising therapeutic target for ESCC chemotherapy." 3 "CircSOS2 promotes cervical squamous cell carcinoma by regulation of proliferation, cell cycle, apoptosis, migration, invasion, and glycolysis by targeting miR-543/FNDC3B axis." - hsa_circ_SOS2 CircSOS2 DOID:3744 cervical squamous cell carcinoma cervical squamous cell carcinoma RT-qPCR up-regulated "CircSOS2 conferred an oncogenic function in SCC by regulation of proliferation, cell cycle, apoptosis, migration, invasion, and glycolysis of SCC cells, which was contributed to its interactions with miR-543 and FNDC3B." 1 Circular RNA circ_0006948 Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating microRNA-3612/LASP1 Axis. hsa_circ_0006948 hsa_circ_FNDC3B - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "Circ_0006948 boosted ESCC progression partly by regulating the miR-3612/LASP1 axis, providing an underlying therapeutic target for the ESCC treatment." 4 "Circular RNA circ_0010235 sponges miR-338-3p to play oncogenic role in proliferation, migration and invasion of non-small-cell lung cancer cells through modulating KIF2A." hsa_circ_0010235 hsa_circ_ALDH4A1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated Circ_0010235 was an upregulated circRNA in NSCLC patients and cells.Interfering circ_0010235 restrained NSCLC cell proliferation and metastasis in vitro and in vivo.miR-338-3p per se suppressed NSCLC in vitro and its downregulation diminished the tumour-suppressive role of circ_0010235 blockage in NSCLC cells.miR-338-3p could downstream target KIF2A and be sponged by circ_0010235. 4 Blocking hsa_circ_0006168 suppresses cell proliferation and motility of human glioblastoma cells by regulating hsa_circ_0006168/miR-628-5p/IGF1R ceRNA axis. hsa_circ_0006168 hsa_circ_CNOT6L - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated Silencing hsa_circ_0006168 might suppress GBM proliferation and motility via serving as competitive endogenous RNA for miR-628-5p and regulating IGF1R/Ras/Erk pathway. 1 Targeting a novel hsa_circ_0000520/miR-556-5p/NLRP3 pathway-mediated cell pyroptosis and inflammation attenuates ovalbumin (OVA)-induced allergic rhinitis (AR) in mice models. hsa_circ_0000520 - - DOID:4481 allergic rhinitis allergic rhinitis RT-qPCR up-regulated "Taken together, we evidenced that targeting the hsa_circ_0000520/miR-556-5p/NLRP3 signaling pathway was a novel AQ1strategy to ameliorate AR progression; however, future clinical data are still required to validate our preliminary results." 1 Circular RNA hsa_circ_0001874 is an indicator for gastric cancer. hsa_circ_0001874 hsa_circ_BICD2 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated hsa_circ_0001874 is an indicator of GC and plays a significant role in gastric carcinogenesis and progression. 1 Profiling of circular RNAs and circTPCN/miR-634/mTOR regulatory pathway in cervical cancer. - hsa_circ_TPCN circTPCN DOID:4362 cervical cancer cervical cancer "RT-qPCR, microarray" up-regulated "the circTPCN/miR-634/mTOR regulatory pathway might be involved in cervical cancer tumorigenesis, and circTPCN is a potential therapeutic target in cervical cancer." 1 Hsa_circRNA_102229 facilitates the progression of triple-negative breast cancer via regulating the miR-152-3p/PFTK1 pathway. - - circRNA_102229 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated Hsa_circ_102229 might serve as a competing endogenous RNA (ceRNA) to modulate PFTK1 expression via regulating miR-152-3p to affect the functions of TNBC cells. 1 Circ_0027599 elevates RUNX1 expression via sponging miR-21-5p on gastric cancer progression. hsa_circ_0027599 - Circ_0027599 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "circ_0027599 overexpression repressed tumour growth in vivo. CONCLUSION: Circ_0027599 overexpression repressed GC progression via modulation of miR-21-5p/RUNX1 axis, which might illumine a novel therapeutic target for GC." 2 Circ-sirt1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression. - hsa_circ_sirt1 circ-sirt1 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated circ-sirt1 inhibited tumor growth and invasion probably by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression in GC. 1 circ-PTK2 (hsa_circ_0008305) regulates the pathogenic processes of ovarian cancer via miR-639 and FOXC1 regulatory cascade. hsa_circ_0008305 hsa_circ_PTK2 circ-PTK2 DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, RNA-seq" up-regulated "By regulating the level of circ-PTK2 with siRNA and an overexpression vector, expression of circ-PTK2 was found to be positively correlated to cell migration and invasion. Overexpression of circ-PTK2 enhanced tumor formation and was correlated to expression of EMT pathway markers. Prediction of the target of circ-PTK2 was validated with dual luciferase assay and identified miR-639 and FOXC1 as the valid target of circ-PTK2 and miR-639, respectively." 1 "Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3." hsa_circ_0001367 - Circ_0001367 DOID:0060108 brain glioma glioma RT-qPCR down-regulated circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas. 2 Circ_RPL23A acts as a miR-1233 sponge to suppress the progression of clear cell renal cell carcinoma by promoting ACAT2. - hsa_circ_RPL23A - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR down-regulated Circ_RPL23A inhibited ccRCC progression by upregulating ACAT2 expression by competitively binding miR-1233. 1 Dysregulation of tumour microenvironment driven by circ-TPGS2/miR-7/TRAF6/NF-kappaB axis facilitates breast cancer cell motility. - hsa_circ_TPGS2 circ-TPGS2 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Dysregulation of tumour microenvironment driven by circ-TPGS2/miR-7/TRAF6/NF-kappaB axis facilitates breast cancer cell motility. 1 Circ_0019435 Exerts Its Functions in the Cellular Process of Cervical Cancer via Epigenetically Silencing DKK1 and PTEN. hsa_circ_0019435 - Circ_0019435 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circ_0019435 regulates DKK1 and PTEN expression at the epigenetic level, thereby influencing the progression of CC cells." 1 Circular RNA circWDR27 Promotes Papillary Thyroid Cancer Progression by Regulating miR-215-5p/TRIM44 Axis. - hsa_circ_WDR27 circWDR27 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "CircWDR27 accelerates PTC progression via regulating miR-215-5p/TRIM44 axis, providing a potential therapeutic target for PTC." 2 Circ_0001944 Contributes to Glycolysis and Tumor Growth by Upregulating NFAT5 Through Acting as a Decoy for miR-142-5p in Non-Small Cell Lung Cancer. hsa_circ_0001944 - Circ_0001944 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0001944 promotes proliferation, migration, invasion, and glycolysis of NSCLC cells by upregulating NFAT5 through adsorbing miR-142-5p, offering a novel mechanism for understanding the advancement of NSCLC." 1 CircANKRD36 Knockdown Suppressed Cell Viability and Migration of LPS-Stimulated RAW264.7 Cells by Sponging MiR-330. - hsa_circ_ANKRD36 circANKRD36 DOID:850 lung disease Acute lung injury RT-qPCR down-regulated "In short, circANKRD36 knockdown suppressed cell viability and migration of LPS-stimulated RAW264.7 cells in vitro via sponging miR-330, which may provide new ideas for the treatment of sepsis-induced ARDS." 1 CircHelz activates NLRP3 inflammasome to promote myocardial injury by sponging miR-133a-3p in mouse ischemic heart. - hsa_circ_Helz circHelz DOID:5844 myocardial infarction Myocardial infarction RT-qPCR up-regulated interfering with circHelz/miR-133a-3p/NLRP3 axis might be a promising therapeutic approach for ischemic cardiac diseases. 1 Sevoflurane Suppresses Colon Cancer Cell Malignancy by Regulating circ-PI4KA. - hsa_circ_PI4KA circ-PI4KA. DOID:219 colon cancer colon cancer RT-qPCR up-regulated "Circ-PI4KA attenuated SEV-treated colon cancer cell malignancy by upregulating LASP1 through binding to miR-331-3p, which provided a new mechanism for studying surgery-mediated therapy of colon cancer." 1 CircMYBL2 regulates the resistance of cervical cancer cells to paclitaxel via miR-665-dependent regulation of EGFR. - hsa_circ_MYBL2 CircMYBL2 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "CircMYBL2 played a positive role in the PTX resistance and malignant activities of PTX-sensitive and PTX-resistant CC cells by regulating the miR-665/EGFR network, providing a novel therapeutic strategy for the treatment of CC patients resistant to PTX." 2 hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p. hsa_circ_0008234 hsa_circ_FOXP1 circ_0008234 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated circ_0008234 inhibited the progression of LUAC through a competing endogenous RNA (ceRNA)-based mechanism and provided potential biomarkers and therapeutic targets for LUAC treatment. 1 CircARL8B Contributes to the Development of Breast Cancer Via Regulating miR-653-5p/HMGA2 Axis. - hsa_circ_ARL8B CircARL8B DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circARL8B knockdown might block PGE2/PI3K/AKT/GSK-3beta/Wnt/beta-catenin pathway. Silencing of circARL8B inhibited cell viability, migration, invasion and fatty acid metabolism via miR-653-5p/HMGA2 axis in BC." 2 CircRNA circ_0006677 Inhibits the Progression and Glycolysis in Non-Small-Cell Lung Cancer by Sponging miR-578 and Regulating SOCS2 Expression. hsa_circ_0006677 hsa_circ_WDR78 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated circ_0006677 could inhibit NSCLC progression and glycolysis by regulating the expression of the signal transducer inhibitor SOSC2 through sponging microRNA-578 (miR-578). 2 Mechanism of circADD2 as ceRNA in Childhood Acute Lymphoblastic Leukemia. - hsa_circ_ADD2 circADD2 DOID:9952 acute lymphoblastic leukemia acute lymphoblastic leukemia "RT-qPCR, microarray" down-regulated "Overexpression of circADD2 inhibited cell proliferation and promoted apoptosis both in vitro and in vivo. Briefly, circADD2 could directly sponge miR-149-5p, and the level of AKT2, a target gene of miR-149-5p, was downregulated by circADD2." 1 Silencing of circRNA circ_0001666 Represses EMT in Pancreatic Cancer Through Upregulating miR-1251 and Downregulating SOX4. hsa_circ_0001666 hsa_circ_FAM120B - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "circ_0001666 acts as an oncogenic circRNA to promote EMT and invasion of PC cells through sponging miR-1251, and indicated that circ_0001666 could be explored as a potential therapeutic target for PC." 1 Mechanisms of circular RNA circ_0066147 on pancreatic cancer progression. hsa_circ_0066147 hsa_circ_SFMBT1 - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "circ_0066147 regulated PC malignant progression in part depending on the miR-326/E2F2 axis, illuminating circ_0066147 was a potential prognostic marker and therapeutic target for PC management." 1 "CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a." - hsa_circ_MYLK CircMYLK DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated CircMYLK contributed to the malignant development of bladder cancer cells partly through the miR-34a/CCND3 regulatory network. 3 Circular RNA circ_0001162 promotes cell proliferation and invasion of glioma via the miR-936/ERBB4 axis. hsa_circ_0001162 hsa_circ_MMP9 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circ_0001162 contributed to the glioma progression via regulating the miR-936/ERBB4 axis, which laid a foundation for the pathomechanism and molecular treatment of glioma." 1 CircMAPK1 promotes the proliferation and migration of vascular smooth muscle cells through miR-22-3p/ methyl-CpG binding protein 2 axis. - mmu_circ_MAPK1 CircMAPK1 DOID:1936 atherosclerosis atherosclerosis "RT-qPCR, RNA-seq" up-regulated CircMPAK1 promoted the proliferation and migration of VSMCs through miR-22-3p/MECP2 axis. Our study revealed the role of circMAPK1 in atherosclerosis and shed lights on the treatment of atherosclerosis. 1 Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis. hsa_circ_0102049 - circ_0102049 DOID:3347 osteosarcoma osteosarcoma RT-qPCR dysregulated "circ_0102049 suppressed the progression of osteosarcoma via modulating miR-520g-3p/PLK2/TAp73 axis, providing a potential therapeutic target for OS." 2 Circ_0001666 affects miR-620/WNK2 axis to inhibit breast cancer progression. hsa_circ_0001666 - Circ_0001666 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated Circ_0001666 hindered the progression of BC via miR-620/WNK2 axis. 2 Expression profile and bioinformatics analysis of circular RNAs in tongue squamous cell carcinoma. hsa_circ_0066251 hsa_circ_APPL1 - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated the expression levels of hsa_circ_0066251 and hsa_circ_0003161 in TSCC tissues were significantly lower than in normal tissues while hsa_circ_0005035 and hsa_circ_0002360 were significantly upregulated in TSCC tissues when compared with their matched adjacent normal tissues in 40 TSCC patients. 1 Expression profile and bioinformatics analysis of circular RNAs in tongue squamous cell carcinoma. hsa_circ_0003161 hsa_circ_PIK3R3 - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated the expression levels of hsa_circ_0066251 and hsa_circ_0003161 in TSCC tissues were significantly lower than in normal tissues while hsa_circ_0005035 and hsa_circ_0002360 were significantly upregulated in TSCC tissues when compared with their matched adjacent normal tissues in 40 TSCC patients. 1 Expression profile and bioinformatics analysis of circular RNAs in tongue squamous cell carcinoma. hsa_circ_0005035 hsa_circ_IGF1R - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated the expression levels of hsa_circ_0066251 and hsa_circ_0003161 in TSCC tissues were significantly lower than in normal tissues while hsa_circ_0005035 and hsa_circ_0002360 were significantly upregulated in TSCC tissues when compared with their matched adjacent normal tissues in 40 TSCC patients. 1 Expression profile and bioinformatics analysis of circular RNAs in tongue squamous cell carcinoma. hsa_circ_0002360 hsa_circ_RUNX1 - DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated the expression levels of hsa_circ_0066251 and hsa_circ_0003161 in TSCC tissues were significantly lower than in normal tissues while hsa_circ_0005035 and hsa_circ_0002360 were significantly upregulated in TSCC tissues when compared with their matched adjacent normal tissues in 40 TSCC patients. 1 The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway. - hsa_circ_SPARC circSPARC DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Silencing circSPARC inhibited CRC cell migration and proliferation in vitro and vivo. Mechanistically, circSPARC sponged miR-485-3p to upregulate JAK2 expression and ultimately contribute to the accumulation of phosphorylated (p)-STAT3. Besides, circSPARC recruited FUS, which facilitated the nuclear translocation of p-STAT3." 1 Circ_0021087 acts as a miR-184 sponge and represses gastric cancer progression by adsorbing miR-184 and elevating FOSB expression. hsa_circ_0021087 hsa_circ_LMO1 Circ_0021087 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "circ_0021087 played a repressive influence on GC progression by elevating FOSB expression by adsorbing miR-184, offering a new mechanism for circ_0021087 to inhibit the progression of GC." 3 Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer. hsa_circ_0003028 hsa_circ_FUT8 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ_0003028 knockdown could suppress NSCLC progression partly by regulating the miR-1298-5p/GOT2 axis, providing an underlying therapeutic target for NSCLC." 3 Circ_0091702 relieves lipopolysaccharide (LPS)-induced cell injury by regulating the miR-182/PDE7A axis in sepsis. hsa_circ_0091702 - circ_0091702 DOID:0040085 bacterial sepsis sepsis RT-qPCR down-regulated "Our data suggested that circ_0091702 sponged miR-182 to regulate PDE7A, thereby alleviating LPS-induced cell injury in sepsis." 1 CircHECTD1 Regulates Cell Proliferation and Migration by the miR-320-5p/SLC2A1 Axis in Glioblastoma Multiform. - hsa_circ_HECTD1 CircHECTD1 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "the circHECTD1-miR-320-5p-SLC2A1 regulatory pathway promoted the progression of GBM, suggesting that circHECTD1 may be a therapeutic target for GBM." 1 circSAMD4A participates in the apoptosis and autophagy of dopaminergic neurons via the miR_29c_3p_mediated AMPK/mTOR pathway in Parkinson disease. - hsa_circ_SAMD4A circSAMD4A DOID:14330 Parkinson disease Parkinson disease RT-qPCR up-regulated circSAMD4A participated in the apoptosis and autophagy of dopaminergic neurons by modulating the AMPK/mTOR cascade via miR_29c_3p in PD. 1 circNSUN2 promotes the malignant biological behavior of colorectal cancer cells via the miR_181a_5p/ROCK2 axis. - hsa_circ_NSUN2 circNSUN2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circNSUN2 promoted the progression of CRC by sponging miR_181a_5p to increase the expression of ROCK2. 3 Exosomal circ-BRWD1 contributes to osteoarthritis development through the modulation of miR-1277/TRAF6 axis. - hsa_circ_BRWD1 circ-BRWD1 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Exosomal circ-BRWD1 promoted IL-1beta-induced CHON-001 cell progression by regulating miR-1277/TRAF6 axis. 1 Circular RNA circHIPK3 Activates Macrophage NLRP3 Inflammasome and TLR4 Pathway in Gouty Arthritis via Sponging miR-561 and miR-192. - hsa_circ_HIPK3 circHIPK3 DOID:13189 gout gouty arthritis RT-qPCR up-regulated "circHIPK3 sponges miR-192 and miR-561 to promote TLR4 and NLRP3 expressions, thereby promoting inflammatory response in gouty arthritis." 1 Circ-ACAP2 facilitates the progression of colorectal cancer through mediating miR-143-3p/FZD4 axis. - hsa_circ_ACAP2 Circ-ACAP2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ-ACAP2 contributed to the development and radioresistance of CRC partly through targeting miR-143-3p/FZD4 axis, which provided novel potential diagnostic and therapeutic targets for CRC." 1 Hsa_circ_0031787 promotes cell proliferation and invasion in colorectal cancer. hsa_circ_0031787 hsa_circ_POLE2 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Hsa_circ_0031787 expression levels in CRC were significantly increased and correlated with advanced TNM stage and lymph node metastasis in CRC patients. Functional assays showed that hsa_circ_0031787 suppression reduced CRC cell proliferation and invasion in vitro and reduced tumor growth in vivo. Furthermore, hsa_circ_0031787 suppression reduced activation of the Wnt/beta-catenin axis in CRC." 1 Sevoflurane suppresses glioma tumorigenesis via regulating circ_0079593/miR-633/ROCK1 axis. hsa_circ_0079593 - circ_0079593 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Sevoflurane repressed glioma tumorigenesis via regulating circ_0079593/miR-633/ROCK1 axis, suggesting a new insight into the application of sevoflurane in glioma therapy." 3 Circ_0084615 is an oncogenic circular RNA in colorectal cancer and promotes DNMT3A expression via repressing miR-599. hsa_circ_0084615 - Circ_0084615 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated Circ_0084615 is a tumor-promoting circRNA in CRC that functions as a competing endogenous RNA to regulate DNMT3A expression via sponging miR-599. 2 CircHACE1 functions as a competitive endogenous RNA to curb differentiated thyroid cancer progression by upregulating Tfcp2L1 through adsorbing miR-346. - hsa_circ_HACE1 CircHACE1 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR down-regulated "circHACE1 adsorbed miR-346 and elevated Tfcp2L1 expression, thus curbing cell malignancy in differentiated THCA." 1 Circular RNA circDUS2 Is a Potential Biomarker for Intracranial Aneurysm. - hsa_circ_DUS2 circDUS2 DOID:10941 intracranial aneurysm Intracranial Aneurysm "RT-qPCR, microarray" up-regulated Quantitative real-time PCR verified the elevated expression of the upregulated circDUS2. The FISH test revealed that circDUS2 is located in the cytoplasm of brain vascular smooth muscle cells. 1 "Circ-MFN2 Positively Regulates the Proliferation, Metastasis, and Radioresistance of Colorectal Cancer by Regulating the miR-574-3p/IGF1R Signaling Axis." - hsa_circ_MFN2 Circ-MFN2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ-MFN2 promoted the proliferation, metastasis and radioresistance of CRC through regulating the miR-574-3p/IGF1R axis, suggesting that circ-MFN2 might be a novel therapeutic biomarker for CRC." 1 circ0101675 promotes malignant process via sponging miR-1278 and upregulating WNT3A/5A in non-small cell lung cancer. hsa_circ_0101675 - circ0101675 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated circ0101675 promotes malignant process via sponging miR-1278 and upregulating WNT3A/5A in non-small cell lung cancer. 1 Overexpressed circRANBP17 acts as an oncogene to facilitate nasopharyngeal carcinoma via the miR-635/RUNX2 axis. hsa_circ_0001554 hsa_circ_RANBP17 circRANBP17 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "circRANBP17 is a new onco-circRNA via miR-635/RUNX2 axis regulation, and may function as a novel therapeutic target for NPC treatment.." 1 Circular RNA circLDB2 functions as a competing endogenous RNA to suppress development and promote cisplatin sensitivity in non-squamous non-small cell lung cancer. - hsa_circ_LDB2 circLDB2 DOID:3908 lung non-small cell carcinoma non-squamousnon-small cell lung cancer RT-qPCR down-regulated "circLDB2 impeded non-squamous NSCLC development and enhanced cisplatin sensitivity partially by acting as a ceRNA, highlighting circLDB2 as a promising candidate for the development of novel antitumor therapies." 4 "Circ_0000615 promotes high glucose-induced human retinal pigment epithelium cell apoptosis, inflammation and oxidative stress via miR-646/YAP1 axis in diabetic retinopathy." hsa_circ_0000615 - circ_0000615 DOID:8947 diabetic retinopathy Diabetic retinopathy RT-qPCR up-regulated "Circ_0000615 contributed to HG-induced HRPE cell dysfunction via miR-646/YAP1 axis, suggesting a novel insight into the pathogenesis of DR and a potential candidate for DR treatment." 2 Circular RNA hsa_circ_0032463 Acts as the Tumor Promoter in Osteosarcoma by Regulating the MicroRNA 498/LEF1 Axis. hsa_circ_0032463 hsa_circ_SIPA1L1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "by binding to miR-498 and inhibiting LEF1 expression, circ_0032463 promoted the migration and proliferation abilities of OS cells and suppressed the apoptosis ability of OS cells." 3 Downregulation of circ_0012152 inhibits proliferation and induces apoptosis in acute myeloid leukemia cells through the miR-625-5p/SOX12 axis. hsa_circ_0012152 - circ_0012152 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated Circ_0012152 knockdown suppressed cell proliferation and promoted death by targeting SOX12 mediated by miR-625-5p in AML cells. 1 Hsa_circ_0044235 regulates the pyroptosis of rheumatoid arthritis via MiR-135b-5p-SIRT1 axis. hsa_circ_0044235 hsa_circ_CDC27 circ_0044235 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR down-regulated Hsa_circ_0044235 regulated NLRP3-mediated pyroptosis through miR-135b-5p-SIRT1 axis to regulate the development of RA. 3 CircPUM1 promotes cell growth and glycolysis in NSCLC via up-regulating METTL3 expression through miR-590-5p. - hsa_circ_PUM1 CircPUM1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircPUM1 promoted NSCLC tumor growth and glycolysis through sequestering miR-590-5p and up-regulating METTL3, providing an improved understanding of NSCLC tumorigenesis and a potential therapeutic target for NSCLC therapy." 1 Gastric Cancer Cell-Derived Exosomes Can Regulate the Biological Functions of Mesenchymal Stem Cells by Inducing the Expression of Circular RNA circ_0004303. hsa_circ_0004303 hsa_circ_DDX60 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated Hsa_circ_0004303 can regulate the migration and invasion of human adipose-derived MSCs via the miR-148a-3P/ALCAM axis. 1 Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury. - mmu_circ_Prkcsh circPrkcsh DOID:13743 spinal cord lipoma spinal cord injury RT-qPCR down-regulated "circPrkcsh may be used as an miR-488 sponge to regulate Ccl2 expression, which might provide a new potential therapy for SCI." 2 Circ_0091702 serves as a sponge of miR-545-3p to attenuate sepsis-related acute kidney injury by upregulating THBS2. hsa_circ_0091702 - circ_0091702 DOID:3021 acute kidney failure acute kidney injury RT-qPCR down-regulated "In conclusion, our results showed that circ_0091702 could suppress LPS-induced HK2 cell injury via the miR-545-3p/THBS2 axis, indicating that circ_0091702 might be an important biomarker for relieving sepsis-related AKI." 1 Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138-5p/SLC7A5 axis. - hsa_circ_FAM158A circ-FAM158A DOID:768 retinoblastoma retinoblastoma RNA-seq up-regulated "Circ-FAM158A knockdown inhibited the progression of RB by regulating miR-138-5p/SLC7A5 axis, which provided new insights into the pathogenesis of RB." 3 "circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis." - hsa_circ_VAPA circVAPA DOID:8618 oral cavity cancer oral cancer RT-qPCR up-regulated "circVAPA is highly expressed in oral cancer, and its abnormal expression might affect the proliferation, invasion and migration of oral cancer cells by modulating the miR-132/HOXA7 signaling axis." 1 Circular RNA circ_0001588 sponges miR-211-5p to facilitate the progression of glioblastoma via up-regulating YY1 expression. hsa_circ_0001588 hsa_circ_HIST1H4E - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "circ_0001588 accelerates the proliferation, migration and invasion of GBM by modulating miR-211-5p/YY1 signaling." 1 circRPS28 (hsa_circ_0049055) is a novel contributor for papillary thyroid carcinoma by regulating cell growth and motility via functioning as ceRNA for miR-345-5p to regulate frizzled family receptor 8 (FZD8). hsa_circ_0049055 hsa_circ_RPS28 circRPS28 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "In conclusion, we demonstrated that blocking circRPS28 and/or promoting miR-345-5p suppressed PTC cell growth and motility via regulating FZD8. This study might suggest a novel circRPS28/miR-345-5p/FZD8 competing endogenous RNA pathway in PTC." 1 CircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis. - hsa_circ_C16orf62 CircC16orf62 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircC16orf62 functions as an oncogene in HCC progression, behaving as a competitive endogenous RNA for miR-138-5p binding, thus activating the AKT/mTOR pathway." 1 Exosomal Circular RNA RNA-seq Profiling and the Carcinogenic Role of Exosomal circ-CYP24A1 in Cutaneous Squamous Cell Carcinoma. - hsa_circ_CYP24A1 circ-CYP24A1 DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "exosomal circ-CYP24A1 could suppress cSCC progression by weakening tumor malignant behaviors, which might provide a promising therapeutic target and non-invasive diagnostic biomarker for cSCC." 1 CircRNA NALCN acts as an miR-493-3p sponge to regulate PTEN expression and inhibit glioma progression. - hsa_circ_NALCN CircNALCN DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" down-regulated "circNALCN acted as a competing endogenous RNA for miR-493-3p to relieve the repressive effects of miR-493-3p on its target, PTEN, suppressing glioma tumorigenesis." 1 CircPVT1 promotes proliferation of lung squamous cell carcinoma by binding to miR-30d/e. - hsa_circ_PVT1 CircPVT1 DOID:3907 lung squamous cell carcinoma lung squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated CircPVT1 promotes LUSC progression via HuR/circPVT1/miR-30d and miR-30e/CCNF cascade. 1 Circular RNA CircHIPK3 Promotes Homeostasis of the Intestinal Epithelium by Reducing MicroRNA 29b Function. - hsa_circ_HIPK3 circHIPK3 DOID:5295 intestinal disease intestinal acute injury RT-qPCR up-regulated "In studies of mice, IECs, and human tissues, our results indicate that circHIPK3 improves repair of the intestinal epithelium at least in part by reducing miR-29b availability." 1 The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC. - hsa_circ_ACTN4 circACTN4 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated Our findings uncover a pivotal mechanism that circACTN4 mediated by USF2 might interact with FUBP1 to promote the occurrence and development of breast cancer via enhancing the expression of MYC. CircACTN4 could be a novel potential target for diagnosis and treatment of breast cancer. 1 Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis. hsa_circ_0075503 - circ_0075503 DOID:288 endometriosis of uterus endometriosis RT-qPCR up-regulated "Circ_0075503 could regulate KLF12 expression by sponging miR-15a-5p. Knockdown of circ_0075503 inhibited E2-induced enhancement of cell migration and invasion in eutopic ESCs by regulating miR-15a-5p/KLF12 axis, indicating a novel target for the treatment of endometriosis." 1 Circular RNA circFOXO3 regulates KDM2A by targeting miR-214 to promote tumor growth and metastasis in oral squamous cell carcinoma. - hsa_circ_FOXO3 circFOXO3 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "circFOXO3 sponges miR-214 to up-regulate the expression of KDM2A, thus promotes tumor progression in OSCC." 1 circ_0001461 promotes oral squamous cell carcinoma progression through miR-145/TLR4/NF-kappaB axis. hsa_circ_0001461 - circ_0001461 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated circ_0001461 promotes oral squamous cell carcinoma progression through miR-145/TLR4/NF-kappaB axis. 1 Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis. - hsa_circ_CSPP1 circ-CSPP1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Our present study identified the oncogenic role of circ-CSPP1 in CRC partially by the modulation of the miR-431/LASP1 axis, providing evidence for circ-CSPP1 as a promising biomarker for CRC management." 3 Hsa_circ_0042823 accelerates cancer progression via miR-877-5p/FOXM1 axis in laryngeal squamous cell carcinoma. hsa_circ_0042823 hsa_circ_SSH2 - DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "Hsa_circ_0042823 promotes FOXM1 expression by sponging miR-877-5p.Hsa_circ_0042823 promotes proliferation, migration, invasion of LSCC cells.Hsa_circ_0042823 knockdown inhibits tumour growth of LSCC via miR-877-5p/FOXM1 axis." 1 CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205. - hsa_circ_ASXL1 CircASXL1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated CircASXL1 acted an oncogenic role in CRC malignant progression via inducing GRIK3 through sponging miR-1205. 1 Circ_0072995 Promotes Ovarian Cancer Progression Through Regulating miR-122-5p/SLC1A5 Axis. hsa_circ_0072995 - Circ_0072995 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Circ_0072995 could play oncogenic role in tumorigenesis and malignant development of OC by regulating miR-122-5p/SLC1A5 axis, providing a novel approach for OC treatment." 1 "circHIPK3 (hsa_circ_0000284) Promotes Proliferation, Migration and Invasion of Breast Cancer Cells via miR-326." hsa_circ_0000284 hsa_circ_HIPK3 circHIPK3 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circHIPK3 promoted proliferation, migration and invasion of BCa cells through regulating miR-326." 4 CircRNA CircRIMS is Overexpressed in Esophageal Squamous Cell Carcinoma and Downregulate miR-613 Through Methylation to Increase Cell Proliferation. - hsa_circ_RIMS CircRIMS DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated CircRIMS may downregulate miR-613 through methylation to increase cell proliferation in ESCC. 1 CircKEAP1 Suppresses the Progression of Lung Adenocarcinoma via the miR-141-3p/KEAP1/NRF2 Axis. - hsa_circ_KEAP1 CircKEAP1 DOID:3910 lung adenocarcinoma lung adenocarcinoma "RT-qPCR, microarray" down-regulated circKEAP1 inhibits LUAD progression through circKEAP1/miR-141-3p/KEAP1 axis and it may serve as a novel method for the treatment of LUAD. 1 "Elevated circRNAs circ_0000745, circ_0001531 and circ_0001640 in human whole blood: Potential novel diagnostic biomarkers for breast cancer." hsa_circ_0000745 - circ_0000745 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "QRT-PCR validated that circ_0000745, circ_0001531 and circ_0001640 were upregulated in breast cancer, compared with benign tumor and healthy control." 1 "Elevated circRNAs circ_0000745, circ_0001531 and circ_0001640 in human whole blood: Potential novel diagnostic biomarkers for breast cancer." hsa_circ_0001531 - circ_0001531 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "QRT-PCR validated that circ_0000745, circ_0001531 and circ_0001640 were upregulated in breast cancer, compared with benign tumor and healthy control." 1 "Elevated circRNAs circ_0000745, circ_0001531 and circ_0001640 in human whole blood: Potential novel diagnostic biomarkers for breast cancer." hsa_circ_0001640 - circ_0001640 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "QRT-PCR validated that circ_0000745, circ_0001531 and circ_0001640 were upregulated in breast cancer, compared with benign tumor and healthy control." 1 Circular RNA circHIPK3 modulates prostate cancer progression via targeting miR-448/MTDH signaling. - hsa_circ_HIPK3 circHIPK3 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "circHIPK3 plays a carcinogenic effect in PCa by regulating the miR-448/MTDH axis, indicating that circHIPK3 may be a potential therapeutic target for PCa." 4 Hsa_circ_0008234 facilitates proliferation of cutaneous squamous cell carcinoma through targeting miR-127-5p to regulate ADCY7. hsa_circ_0008234 hsa_circ_FOXP1 - DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma "RT-qPCR, microarray" up-regulated Hsa_circ_0008234 was positively associated with ADCY7 expression in cSCC tissues. Hsa_circ_0008234 facilitates the proliferation of cSCC through targeting miR-127-5p to regulate ADCY7 expression and has the potential to be a novel therapeutic target for cSCC. 1 "CircZNF124 regulates cell proliferation, leucine uptake, migration and invasion by miR-199b-5p/SLC7A5 pathway in endometrial cancer." - hsa_circ_ZNF124 CircZNF124 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "CircZNF124 depletion inhibited EC cell malignancy by miR-199b-5p/SLC7A5 pathway, which demonstrated that circZNF124 had the potential as a therapeutic target for EC." 2 Circ_0072088 promotes progression of hepatocellular carcinoma by activating JAK2/STAT3 signaling pathway via miR-375. hsa_circ_0072088 - Circ_0072088 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0072088 can enhance the proliferation, migration, and invasion, and impede apoptosis of HCC cells. Mechanistically, circ_0072088 activates JAK2/STAT3 signaling pathway by serving as a molecular sponge of miR-375." 2 "Circular RNA circ_0084927 regulates proliferation, apoptosis, and invasion of breast cancer cells via miR-142-3p/ERC1 pathway." hsa_circ_0084927 - circ_0084927 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0084927 can promote the progression of BC by regulating the miR-142-3p/ERC1 axis. 1 circ_0030018 promotes glioma proliferation and metastasis. hsa_circ_0030018 - circ_0030018 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circ_0030018 enhanced glioma progression by sponging miR-194-5p to regulate TRIM44, indicating that circ_0030018 might be a potential treatment target for glioma." 4 The role of circTMOD3 in regulating LPS-induced acute inflammation and injury in human lung fibroblast WI-38 cells. hsa_circ_0035292 hsa_circ_TMOD3 circTMOD3 DOID:552 pneumonia pneumonia RT-qPCR up-regulated Our findings demonstrated the regulation of circTMOD3 in LPS-induced cell injury and inflammation at least partially via miR-146b-3p-independent modulation of CXCR1. 3 "Emodin alleviates high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation of mesangial cells by the circ_0000064/miR-30c-5p/Lmp7 axis." hsa_circ_0000064 - circ_0000064 DOID:9743 diabetic neuropathy diabetic nephropathy RT-qPCR up-regulated "Our findings identified that emodin alleviated HG-induced oxidative stress, inflammation and ECM accumulation in SV40-MES13 cells at least partially by the regulation of the circ_0000064/miR-30c-5p/Lmp7_xis." 1 Circular RNA circHIPK3 promotes breast cancer progression via sponging MiR-326. - hsa_circ_HIPK3 circHIPK3 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated CircHIPK3 sponges miR-326 to promote BCa growth and metastasis. 4 CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p/PPM1A axis. - hsa_circ_MAPK9 CircMAPK9 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "CircMAPK9 knockdown might inhibit cell proliferation, migration, invasion, inflammatory response, and facilitate apoptosis in RA-FLSs via regulating miR-140-3p/PPM1A axis, offering a new mechanism for the comprehension of RA development and a new insight into the potential application of circMAPK9 in RA treatment." 2 CircRNA_103801 accelerates proliferation of osteosarcoma cells by sponging miR-338-3p and regulating HIF-1/Rap1/PI3K-Akt pathway. - - CircRNA_103801 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated CircRNA_103801 accelerates proliferation of osteosarcoma cells by sponging miR-338-3p and regulating HIF-1/Rap1/PI3K-Akt pathway. 1 CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1. - hsa_circ_LRP6 CircLRP6 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "circLRP6 promoted PCa tumorigenesis and metastasis through miR-330-5p/NRBP1 axis, suggesting a potential therapeutic target for PCa." 1 Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer. - hsa_circ_RHOBTB3 circRHOBTB3 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer. 3 "CircMYLK Promotes Cell Proliferation, Migration, and Invasion in Colorectal Cancer." - hsa_circ_MYLK CircMYLK DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "CircMYLK Promotes Cell Proliferation, Migration, and Invasion in Colorectal Cancer." 1 Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p. hsa_circ_0110389 hsa_circ_SORT1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated hsa_circ_0110389 sponged miR-127-5p/miR-136-5p to upregulate SORT1 expression and hsa_circ_0110389 promoted GC progression through the miR-127-5p/miR-136-5p-SORT1 pathway. 1 Circular RNA 0014715 Facilitates Cell Proliferation and Inhibits Apoptosis in Esophageal Squamous Cell Carcinoma. hsa_circ_0014715 hsa_circ_CCT3 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated circ_0014715 is closely connected with the pathogenesis and development of ESCC. The excess expression of circ_0014715 may have promoting effects on the progression of esophageal cell carcinoma. 1 CircRNA HIPK3 promotes the progression of oral squamous cell carcinoma through upregulation of the NUPR1/PI3K/AKT pathway by sponging miR-637. - hsa_circ_HIPK3 CircHIPK3 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Functionally, overexpressed circHIPK3 can significantly promote EMT, proliferation, and invasion of OSCC cells and can inhibit cell apoptosis in vivo and in vitro. In addition, CircHIPK3 upregulated the activation of NUPR1 and PI3K/AKT." 3 Downregulation of hsa_circ_0001681 suppresses epithelial-mesenchymal transition in thyroid carcinoma via targeting to miR-942-5p/TWIST1 signaling pathway. hsa_circ_0001681 hsa_circ_RAPGEF5 - DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated silencing of hsa_circ_0001681 significantly suppressed TC progression through inhibiting EMT via acting as a miR-942-5p sponge to facilitate the expression of TWIST1. 1 Down-regulation of hsa_circ_0006470 predicts tumor invasion: A new biomarker of gastric cancer. hsa_circ_0006470 hsa_circ_MFN2 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Compared with adjacent normal tissues, the expression of hsa_circ_0006470 in GC tissues was significantly lower." 5 Novel circular RNA circSLIT2 facilitates the aerobic glycolysis of pancreatic ductal adenocarcinoma via miR-510-5p/c-Myc/LDHA axis. - hsa_circ_SLIT2 circSLIT2 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" up-regulated Novel circular RNA circSLIT2 facilitates the aerobic glycolysis of pancreatic ductal adenocarcinoma via miR-510-5p/c-Myc/LDHA axis. 1 circMELK promotes glioblastoma multiforme cell tumorigenesis through the miR-593/EphB2 axis. - hsa_circ_MYLK circMELK DOID:3073 brain glioblastoma multiforme glioblastoma multiforme RT-qPCR up-regulated "circMELK was upregulated in GBM, acting as an oncogene and regulating GBM mesenchymal transition and GSC maintenance via sponging of miR-593." 1 circ0093740 Promotes Tumor Growth and Metastasis by Sponging miR-136/145 and Upregulating DNMT3A in Wilms Tumor. hsa_circ_0093740 - circ0093740 DOID:2154 nephroblastoma wilms tumor "RT-qPCR, microarray" up-regulated circ0093740 promotes the growth and migration ability by sponging miR-136/145 and upregulating DNMT3A. 1 "Circ_0002984 induces proliferation, migration and inflammation response of VSMCs induced by ox-LDL through miR-326-3p/VAMP3 axis in atherosclerosis." hsa_circ_0002984 - circ_0002984 DOID:1287 cardiovascular system disease cardiovascular diseases RT-qPCR down-regulated "In conclusion, circ_0002984 mediated cell proliferation, migration and inflammation through modulating miR-326-3p and VAMP3 in VSMCs, which suggested that circ_0002984 might hold great promise as a therapeutic strategy for atherosclerosis." 1 Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 via miR-411-5p. hsa_circ_0001686 - Circ_0001686 DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" up-regulated "Circ_0001686 can reduce miR-411-5p to increase the expression of SMAD3/TGFBR2, which consequently promotes the proliferation, invasion, and migration of PCa cells." 1 "Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis." - - Circ3823 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "circ3823 promotes CRC growth, metastasis and angiogenesis through circ3823/miR-30c-5p/TCF7 axis and it may serve as a new diagnostic marker or target for treatment of CRC patients. In addition, m6A modification is involved in regulating the degradation of circ3823." 1 CircPLCE1 facilitates the malignant progression of colorectal cancer by repressing the SRSF2-dependent PLCE1 pre-RNA splicing. hsa_circ_0019230 hsa_circ_PLCE1 CircPLCE1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated CircPLCE1 facilitates the malignant progression of colorectal cancer by repressing the SRSF2-dependent PLCE1 pre-RNA splicing. 2 Circ_0084043 Facilitates High Glucose-Induced Retinal Pigment Epithelial Cell Injury by Activating miR-128-3p/TXNIP-Mediated Wnt/beta-Catenin Signaling Pathway. hsa_circ_0084043 - circ_0084043 DOID:9351 diabetes mellitus diabetes mellitus RT-qPCR up-regulated circ_0084043 promoted the HG-induced retinal pigment epithelial cell injury through activating the Wnt/beta-catenin signal pathway by the miR-128-3p/TXNIP axis. 1 Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy. - hsa_circ_ACTR2 circ-ACTR2 DOID:9743 diabetic neuropathy Diabetic nephropathy RT-qPCR up-regulated All data have manifested that circ-ACTR2 contributed to the HG-induced DN progression in HRMCs by the mediation of miR-205-5p/HMGA2 axis. 1 "Effect of paeonol on proliferation, apoptosis, migration, invasion and glutamine of gastric cancer cells via circSFMBT2/miR-665 axis." - hsa_circ_SFMBT2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "paeonol can inhibit the proliferation, migration, invasion and glutamine decomposition of gastric cancer HGC-27 cells via circSFMBT2/miR-665 axis, and also induce cell apoptosis." 4 CircRASSF2 acts as a prognostic factor and promotes breast cancer progression by modulating miR-1205/HOXA1 axis. - hsa_circ_RASSF2 CircRASSF2 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "over-expression of miR-1205 decreased HOXA1 protein expression, and HOXA1 protein expression decreased when circRASSF2 were knocked down, and when miR-1205 expression was inhibited, HOXA1 expression was significantly increased." 1 Inhibiting of circ-TLK1 inhibits the progression of glioma through down-regulating PANX1 via targeting miR-17-5p. - hsa_circ_TLK1 circ-TLK1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated Inhibiting of circ-TLK1 inhibits the progression of glioma through down-regulating PANX1 via targeting miR-17-5p. 2 Circ-CSPP1 knockdown suppresses hepatocellular carcinoma progression through miR-493-5p releasing-mediated HMGB1 downregulation. - hsa_circ_CSPP1 Circ-CSPP1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Knockdown of circ-CSPP1 suppressed HCC development both in vitro and in vivo by upregulation of miR-493-5p and downregulation of HMGB1, hinting that circ-CSPP1 participated in HCC pathogenesis." 6 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_002172 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray up-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_002144 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray up-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_001588 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray up-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_000166 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray up-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_000585 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray up-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_000167 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray up-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_402608 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray up-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_006853 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray up-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_001589 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray up-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_008882 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray up-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_406083 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray down-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_104940 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray down-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 Potential mechanism of circRNA_000585 in cholangiocarcinoma. - - circRNA_0063 DOID:4947 cholangiocarcinoma cholangiocarcinoma microarray down-regulated "Microarray hybridization revealed 10 circRNAs with > 3-fold increased expression versus para-cancer (circRNA_002172, circRNA_002144, circRNA_001588, circRNA_000166, circRNA_000585, circRNA_000167, circRNA_402608, circRNA_006853, circRNA_001589, circRNA_008882), and three circRNAs with > 3-fold decreased expression (circRNA_406083, circRNA_104940, circRNA_006349). " 1 CircRNA_100290 promotes GC cell proliferation and invasion via the miR-29b-3p/ITGA11 axis and is regulated by EIF4A3. - - CircRNA_100290 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Elevated circRNA_100290 expression in GC promotes cell proliferation, invasion and EMT via the miR-29b-3p/ITGA11 axis and might be regulated by EIF4A3." 1 Circ-0005105 activates COL11A1 by targeting miR-20a-3p to promote pancreatic ductal adenocarcinoma progression. hsa_circ_0005105 - Circ-0005105 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated Circ-0005105 activates COL11A1 by targeting miR-20a-3p to promote pancreatic ductal adenocarcinoma progression. 1 "Interference with circRNA DOCK1 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by regulating the miR-654-5p/SMAD2 axis." - hsa_circ_DOCK1 circRNA DOCK1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "interference with circRNA DOCK1 inhibited proliferation, invasion and migration of HCC cells by regulating the miR_654_5p/SMAD2 axis." 1 Significance of Circular FAT1 as a Prognostic Factor and Tumor Suppressor for Esophageal Squamous Cell Carcinoma. - hsa_circ_FAT1 CircFAT1 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR down-regulated The expression of miR-548g was upregulated by the downregulation of circFAT1. The overexpression of miR-548g also promoted ESCC cell migration and invasion. 1 Circular RNA circRHOBTB3 is downregulated in hepatocellular carcinoma and suppresses cell proliferation by inhibiting miR-18a maturation. - hsa_circ_RHOBTB3 circRHOBTB3 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated CircRHOBTB3 is downregulated in HCC and may suppress cell proliferation by reducing miR-18a production. 1 "Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis." hsa_circ_0006988 - Circ_0006988 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ_0006988 knockdown reduced xenograft tumor growth. ssCirc_0006988 contributed to the development of NSCLC by miR-491-5p/MAP3K3 axis. 1 Inhibition of circ_0081234 reduces prostate cancer tumor growth and metastasis via the miR-1/MAP 3 K1 axis. hsa_circ_0081234 - circ_0081234 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Exosomal circ_0081234 promoted migration, invasion and epithelial-mesenchymal transition of PCa cells by regulating the miR-1/MAP 3 K1 axis." 1 Silencing of circTASP1 inhibits proliferation and induces apoptosis of acute myeloid leukaemia cells through modulating miR-515-5p/HMGA2 axis. - hsa_circ_TASP1 circTASP1 DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, microarray" up-regulated "circTASP1 acts as a sponge for miR-515-5p to regulate HMGA2, thereby promoting proliferation and inhibiting apoptosis during AML progression." 1 CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis. - hsa_circ_ITCH circ-ITCH DOID:9743 diabetic neuropathy Diabetic nephropathy RT-qPCR down-regulated "In conclusion, circ-ITCH alleviated renal inflammation and fibrosis in STZ-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis." 1 "Circular RNA_0001946 is insufficiently expressed in tumor tissues, while its higher expression correlates with less lymph node metastasis, lower TNM stage, and improved prognosis in NSCLC patients." hsa_circ_0001946 - Circ_0001946 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "Circ_0001946 is insufficiently expressed in tumor tissues, whereas its higher expression correlates with less lymph node metastasis, reduced TNM stage, and improved prognosis in NSCLC patients." 5 ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-beta. - hsa_circ_DOCK5 circ-DOCK5 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, microarray" down-regulated ZEB1-mediated downregulation of circ-DOCK5 facilitates metastasis in ESCC by forming a positive feedback loop with TGF-beta by altering the miR-627-3p/TGFB2 signaling. Targeting this signaling pathway may help suppress progression in ESCC. 1 Circ-TFF1 Facilitates Breast Cancer Development via Regulation of miR-338-3p/FGFR1 Axis. - hsa_circ_TFF1 Circ-TFF1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ-TFF1 knockdown suppressed BC progression by regulating miR-338-3p/FGFR1 axis, providing a promising therapeutic target for BC." 3 "Circ_0001821 knockdown suppresses growth, metastasis, and TAX resistance of non-small-cell lung cancer cells by regulating the miR-526b-5p/GRK5 axis." hsa_circ_0001821 - Circ_0001821 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Depletion of circ_0001821 also blocked tumor growth in vivo. In conclusion, the depletion of circ_0001821 inhibited NSCLC progression, at least in part, by modulating the miR-526b-5p/GRK5 axis." 1 CircRAB3IP upregulates twist family BHLH transcription factor (TWIST1) to promote osteosarcoma progression by sponging miR-580-3p. - hsa_circ_RAB3IP CircRAB3IP DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circRAB3IP acts as an oncogene in OS by regulating miR-580-3p/TWIST1 axis. 1 Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression. hsa_circ_0000277 hsa_circ_PDE3B circPDE3B DOID:1107 esophageal carcinoma esophageal carcinoma "RT-qPCR, microarray" up-regulated "the circPDE3B/miR-4766-5p/LAMA1 axis functions as an oncogenic factor in promoting ESCC cell proliferation, migration, and invasion by inducing EMT, implying its potential prognostic and therapeutic significance in ESCC." 1 Circ_0030998 promotes tumor proliferation and angiogenesis by sponging miR-567 to regulate VEGFA in colorectal cancer. hsa_circ_0030998 - Circ_0030998 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated Circ_0030998 promotes tumor proliferation and angiogenesis by sponging miR-567 to regulate VEGFA in colorectal cancer. 1 Hsa_circ_0069244 acts as the sponge of miR-346 to inhibit non-small cell lung cancer progression by regulating XPC expression. hsa_circ_0069244 hsa_circ_LDB2 circ_0069244 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" down-regulated circ_0069244 restrained NSCLC progression by modulating the miR-346-5p/XPC axis. 4 [Circ_0001666 promotes the proliferation and inhibits apoptosis of non-small cell lung cancer cells by targeting the miR-330-5p/HMGA2 axis]. hsa_circ_0001666 - Circ_0001666 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ_0001666 promotes the proliferation and inhibits apoptosis of NSCLC cells via miR-330-5p/HMGA2 axis. 2 Circular RNA Circ-STIL Contributes to Cell Growth and Metastasis in Hepatocellular Carcinoma via Regulating miR-345-5p/AQP3 Axis. - hsa_circ_STIL circ-STIL DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ-STIL knockdown or miR-345-5p overexpression impeded cell malignant behaviors in HCC cells, and the effects could be reversed by miR-345-5p silence or AQP3 enhancement, respectively. Meanwhile, circ-STIL regulated AQP3 expression by sponging miR-345-5p. Besides, circ-STIL downregulation retarded HCC tumor growth in vivo." 1 CircCSNK1G1 Contributes to the Tumorigenesis of Gastric Cancer by Sponging miR-758 and Regulating ZNF217 Expression. - hsa_circ_CSNK1G1 CircCSNK1G1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circCSNK1G1 accelerated GC progression via the miR-758/ZNF217 axis, suggesting that circCSNK1G1 might be a potential biomarker for GC diagnosis and treatment." 1 CircASXL1 Knockdown Restrains Hypoxia-Induced DDP Resistance and NSCLC Progression by Sponging miR-206. - hsa_circ_ASXL1 CircASXL1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircASXL1 knockdown inhibited DDP resistance, cell proliferation, migration and invasion, whereas induced cell apoptosis under hypoxia by associating with miR-206 in NSCLC. " 1 Hsa_circRNA_000543 Predicts Poor Prognosis and Promotes Cervical Cancer Cell Progression Through Regulating miR-567/ZNF268 Axis. hsa_circ_0000326 hsa_circ_TCONS_l2_00004572 hsa_circRNA_000543 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Hsa_circ_000543 promoted cell proliferation, colony formation, migration and invasion, as well as inhibited cell apoptosis in CC cells. Hsa_circ_000543 directly targeted miR-567/ZNF268 in CC cell lines. In CC tumor tissues and cells, the hsa_circ_000543 expression was negatively correlated with miR-567 expression and showed a positive correlation with ZNF268 expression. " 2 CircCA12 Promotes Malignant Process via Sponging miR-1184 and Upregulating RAS Family in Bladder Cancer. - hsa_circ_CA12 CircCA12 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated CircCA12 Promotes Malignant Process via Sponging miR-1184 and Upregulating RAS Family in Bladder Cancer. 1 circARL15 Plays a Critical Role in Intervertebral Disc Degeneration by Modulating miR-431-5p/DISC1. - hsa_circ_ARL15 circARL15 DOID:90 degenerative disc disease Intervertebral disk degeneration microarray down-regulated "circARL15/miR-431-5p/DISC1 is involved in the pathogenesis of IDD, which might be helpful in determining the diagnostic biomarkers and providing potential therapeutic targets for patients with IDD." 2 circALPL Sponges miR-127 to Promote Gastric Cancer Progression by Enhancing MTDH Expression. - hsa_circ_ALPL circALPL DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "circALPL promotes gastric cancer progression by sponging miR-127, thus upregulating MTDH." 1 Overexpression of hsa_circ_0008274 inhibited the progression of lung adenocarcinoma by regulating HMGA2 via sponging miR-578. hsa_circ_0008274 hsa_circ_UGGT2 - DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated the overexpression of hsa_circ_0008274 repressed the proliferation and invasion of LUAD through downregulating miR-578 and activating HMGA2. 1 Circular RNA hsa_circ_0005046 and hsa_circ_0001791 May Become Diagnostic Biomarkers for Breast Cancer Early Detection. hsa_circ_0005046 hsa_circ_ARL8B - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated our study presented high expression levels of hsa_circ_0005046 and hsa_circ_00017916 in BC. 2 Circular RNA hsa_circ_0005046 and hsa_circ_0001791 May Become Diagnostic Biomarkers for Breast Cancer Early Detection. hsa_circ_0001791 hsa_circ_ADAM9 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated our study presented high expression levels of hsa_circ_0005046 and hsa_circ_00017916 in BC. 3 Hsa-circ_0000064 accelerates the malignant progression of gastric cancer via sponging microRNA-621. hsa_circ_0000064 hsa_circ_B4GALT2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_0000064 expression was negatively correlated with miR-621 expression in GC tissues while positively with SYF2 expression. Circ_0000064 can participate in the GC progression via modulating miR-621/SYF2 axis. 1 Circular RNA circNRIP1 plays oncogenic roles in the progression of osteosarcoma. - hsa_circ_NRIP1 - DOID:3347 osteosarcoma osteosarcoma microarray up-regulated "METTL3-induced circNRIP1 exerted an oncogenic role in osteosarcoma by sponging miR-199a, which may provide new ideas for the treatment of osteosarcoma." 2 Circular RNA TLK1 Promotes Sepsis-Associated Acute Kidney Injury by Regulating Inflammation and Oxidative Stress Through miR-106a-5p/HMGB1 Axis. - hsa_circ_TLK1 circTLK1 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated we concluded that circTLK1 contributed to sepsis-associated AKI by regulating inflammation and oxidative stress through the miR-106a-5p/HMGB1 axis. CircTLK1 and miR-106a-5p may be employed as the potential targets for the treatment of AKI. 1 Hsa_circRNA_102541 regulates the development of atherosclerosis by targeting miR-296-5p/PLK1 pathway. - - circRNA_102541 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "circRNA_102541 was upregulated in atherosclerosis, and knockdown of circRNA_102541 suppressed cell proliferation while promoted apoptosis of HUVEC cells via miR-296-5p/PLK1. This novel pathway may serve essential roles on the development of atherosclerosis, and circRNA_102541 could be a." 1 Circular RNA circCCDC66 promotes glioma proliferation by acting as a ceRNA for miR-320a to regulate FOXM1 expression. - hsa_circ_CCDC66 circCCDC66 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "CircCCDC66 could facilitate glioma cells proliferation, invasion and migration by down-regulating miR-320a and up-regulating FOXM1." 1 EIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway. hsa_circ_0084615 - circ_0084615 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated EIF4A3-induced circ_0084615 played an oncogenic role in CRC development via miR-599/ONECUT2 axis. 2 CircRNA circ-ATAD1 Is Upregulated in Cervical Squamous Cell Carcinoma and Regulates Cell Proliferation and Apoptosis by Suppressing the Maturation of miR-218. - hsa_circ_ATAD1 circ-ATAD1 DOID:3744 cervical squamous cell carcinoma cervical squamous cell carcinoma RT-qPCR up-regulated Circ-ATAD1 is upregulated in CSCC and may regulate cell proliferation and apoptosis by suppressing the maturation of miR-218. 1 Circular RNA circFAT1(e2) Promotes Colorectal Cancer Tumorigenesis via the miR-30e-5p/ITGA6 Axis. - hsa_circ_FAT1(e2) circFAT1(e2) DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circFAT1(e2) could sponge miR-30e-5p, which regulated the expression level of integrin alpha6 (ITGA6), the downstream target gene of miR-30e-5p. Rescue assays demonstrated that knockdown of miR-30e-5p enhanced CRC proliferation and migration via ITGA6." 1 Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development. hsa_circ_0044516 - Circ_0044516 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated the circ_0044516/miR-136/MAT2A axis is involved in lung cancer progression. 1 circSLC6A6 Sponges miR-497-5p to Promote Endometrial Cancer Progression via the PI4KB/Hedgehog Axis. - hsa_circ_SLC6A6 circSLC6A6 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "We found that circSLC6A6 was highly expressed in both EC tissues and cells. And circSLC6A6 promoted the proliferation, migration, and invasion of EC cells in vitro. In vivo, circSLC6A6 promoted tumor growth. Besides, a mechanistic study demonstrated that circSLC6A6 could regulate tumor-associated signaling PI4KB/hedgehog pathway by sponging miR-497-5p. " 1 "Circular RNA VANGL1 knockdown suppressed viability, promoted apoptosis, and increased doxorubicin sensitivity through targeting miR-145-5p to regulate SOX4 in bladder cancer cells." - hsa_circ_VANGL1 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circ_VANGL1 mediated cell viability, apoptosis, and doxorubicin sensitivity by regulating miR-145-5p/SOX4 axis in bladder cancer, providing a potential therapeutic target for bladder cancer therapy." 3 Circular RNA Circ_0003221 Promotes Cervical Cancer Progression by Regulating miR-758-3p/CPEB4 Axis. hsa_circ_0003221 - Circ_0003221 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circ_0003221 acted as a sponge of miR-758-3p to upregulate CPEB4 expression. In addition, circ_0003221 silence also suppressed tumor growth and EMT in vivo." 2 Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN. - hsa_circ_ZNF652 circZNF652 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated circZNF652 is overexpressed in OA and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN. 1 Hsa_circ_0080229 upregulates the expression of murine double minute-2 (MDM2) and promotes glioma tumorigenesis and invasion via the miR-1827 sponging mechanism. hsa_circ_0080229 hsa_circ_EGFR circ_0080229 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "the silencing of circ_0080229 upregulates the expression of miR-1827, which in turn resulted in the suppression of MDM2, and the mediation of the downstream P53 signaling pathway. Circ_0080229 exerted an effect in mediating tumor progression through the MDM2 signaling pathway by sponging miR-1827. " 2 The role of Circ_PRKCI/miR-24-3p in the metastasis of prostate cancer. - hsa_circ_PRKCI - DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Circ_PRKCI is upregulated in PCa tissues, and its level is linked to metastasis rate in PCa patients. It triggers proliferative and metastatic potentials in PCa by downregulating miR-24-3p." 1 Circ-USP9X Inhibition Reduces Oxidized Low-density Lipoprotein-induced Endothelial Cell Injury via the microRNA 599/Chloride Intracellular Channel 4 Axis. hsa_circ_0090231 hsa_circ_USP9X circ-USP9X DOID:1287 cardiovascular system disease cardiovascular disease RT-qPCR up-regulated "In conclusion, circ-USP9X silencing decreased ox-LDL-induced endothelial cell injury via the miR-599/CLIC4 axis, which offered a novel molecular mechanism to comprehend the pathology of AS." 1 Circ-PRKCI Alleviates Lipopolysaccharide-induced Human Kidney 2 Cell Injury by Regulating miR-106b-5p/GAB1 Axis. - hsa_circ_PRKCI circ-PRKCI DOID:3021 acute kidney failure acute kidney injury RT-qPCR down-regulated "Collectively, Circ-PRKCI overexpression attenuated LPS-induced HK-2 cell injury by regulating miR-106b-5p/GAB1 axis." 1 Circular RNA-DPP4 serves an oncogenic role in prostate cancer progression through regulating miR-195/cyclin D1 axis. - hsa_circ_DPP4 circDPP4 DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" up-regulated "Knockdown of circDPP4 also suppressed PCa tumor growth in vivo. We further found that circDPP4 functioned as a competing endogenous RNA (ceRNA) for miR-195 in PCa cells, and miR-195 negatively regulated the expression of oncogenic cyclin D1. Rescue experiments suggested that restoration of miR-195 blocked the oncogenic role of circDPP4 in PCa cells." 3 Circular RNA circ_001422 promotes the progression and metastasis of osteosarcoma via the miR-195-5p/FGF2/PI3K/Akt axis. - - circ_001422 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated "Circ_001422 accelerates OS tumorigenesis and metastasis by modulating the miR-195-5p/FGF2/PI3K/Akt axis, implying that circ_001422 can be therapeutically targeted to treat OS." 1 Hsa_circ_0054633 association of C peptide is related to IL-17 and TNF-alpha in patients with diabetes mellitus receiving insulin treatment. hsa_circ_0054633 - - DOID:9352 type 2 diabetes mellitus type 2 diabetes mellitus RT-qPCR down-regulated "Hsa_circ_0054633 level was lower in T2D with insulin treatment than untreated and was a negative correlation with C peptide, and positively correlated with IL-17 and TNF-¦Á, suggesting that hsa_circ_0054633 may be a potential early indicator of insulin treatment effect to improve inflammation condition." 3 Circular RNA EGLN3 silencing represses renal cell carcinoma progression through the miR-1224-3p/HMGXB3 axis. hsa_circ_0031594 hsa_circ_EGNL3 circ-EGNL3 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "Circ-EGNL3 indirectly upregulated HMGXB3 by targeting miR-1224-3p, and overexpression of circ-EGLN3 reversed the repressive effects of miR-1224-3p on RCC." 1 CircCCT3 Acts as a Sponge of miR-613 to Promote Tumor Growth of Pancreatic Cancer Through Regulating VEGFA/VEGFR2 Signaling. - hsa_circ_CCT3 CircCCT3 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated Increased CircCCT3 suggests a poor prognosis for PC patients and promotes the migration and invasion through targeting VEGFA/VEGFR2 signaling. CircCCT3 may serve as a potential and promising therapeutic target for PC treatment. 1 hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression. hsa_circ_0101119 - - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "hsa_circ_0101119 could facilitate cell proliferation, migration and invasion, and suppress apoptosis in CC via an interaction with EIF4A3 to inhibit TCEAL6 expression, which may provide a potential therapeutic target for CC treatment." 1 CircFBXL5 promotes the 5-FU resistance of breast cancer via modulating miR-216b/HMGA2 axis. - hsa_circ_FBXL5 CircFBXL5 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circFBXL5 could promote the 5-FU resistance of breast cancer by regulating miR-216b/HMGA2 axis. 2 Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation. hsa_circ_0000520 hsa_circ_RPPH1 - DOID:4362 cervical cancer cervical cancer "RT-qPCR, microarray" up-regulated "Silencing hsa_circ_0000520 inhibited cervical cancer cell proliferation and promoted the inhibitory effects of miR-1296 on CDK2, thereby blocking cell cycle progression and promoting apoptosis." 2 High-throughput sequencing identified circular RNA circUBE2K mediating RhoA associated bladder cancer phenotype via regulation of miR-516b-5p/ARHGAP5 axis. hsa_circ_0009154 hsa_circ_UBE2K circUBE2K DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated circUBE2K is a tumor-promoting circRNA in BC that functions as a ceRNA to regulate ARHGAP5 expression via sponging miR-516b-5p. 1 Oncogenic circDHTKD1 promotes tumor growth and metastasis of oral squamous cell carcinoma in vitro and in vivo via upregulating miR-326-mediated GAB1. - hsa_circ_DHTKD1 circDHTKD1 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated circDHTKD1 contributed to OSCC progression in vivo via the miR-326/GAB1 axis. 1 Circular RNA hsa_circ_0033144 (CircBCL11B) regulates oral squamous cell carcinoma progression via the miR-579/LASP1 axis. hsa_circ_0033144 hsa_circ_BCL11B CircBCL11B DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Silencing cirCBCL11B inhibited cell proliferation and migration, and also included cell apoptosis in OSCC cells. miR-145 was identified as a downstream target mediating the effect of circBCL11B by targeting LASP1. miR-145 negatively regulated LASP1 expression, which could be rescued by miR-145 inhibitor." 1 "Circular RNA MAT2B promotes migration, invasion and epithelial-mesenchymal transition of non-small cell lung cancer cells by sponging miR-431." - hsa_circ_MAT2B circMAT2B DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Further functional experiments showed that circMAT2B knockdown markedly inhibited the proliferation, migration, invasion and EMT of NSCLC cells, whereas circMAT2B overexpression led to the opposing results. Mechanistically, circMAT2B could directly interact with miR-431, and subsequently decrease miR-431 expression in NSCLC. The effects of circMAT2B overexpression in NSCLC cells were abrogated by miR-431 restoration." 1 Circular RNA circRNA_0082835 promotes progression and lymphatic metastasis of primary melanoma by sponging microRNA miRNA-429. hsa_circ_0082835 - circRNA_0082835 DOID:1909 melanoma primary melanoma RT-qPCR up-regulated circRNA_0082835 sponges miR-429 to affect the anti-tumor effect of miR-429 in primary melanoma and lymphatic metastasis. 1 "Circular RNA circSETD3 hampers cell growth, migration, and stem cell properties in bladder cancer through sponging miR-641 to upregulate PTEN." - hsa_circ_SETD3 circSETD3 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated circSETD3 acted as a vital tumor suppressor in BLCA via regulating the miR-641/PTEN axis. 1 Increased levels of circulating circular RNA (hsa_circ_0013587) may serve as a novel biomarker for pancreatic cancer. hsa_circ_0013587 hsa_circ_LRIG2 - DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated "Hsa_circ_0013587 was highly expressed in the pancreatic cancer tissues, cell lines and plasma samples from patients with pancreatic cancer. Notably, hsa_circ_0013587 was upregulated in pancreatic cancer patients with later clinical stages III-IV as compared with those detected in early clinical stages I-II." 1 Circ_0000317/microRNA-520g/HOXD10 axis affects the biological characteristics of colorectal cancer. hsa_circ_0000317 - Circ_0000317 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Functionally, circ_0000317 overexpression repressed CRC cell proliferation, migration, and invasion. Mechanistically, miR-520g was a direct target of circ_0000317 and miR-520g specifically modulated HOXD10 expression." 1 "circ_0101802 functions as a sponge of miR-1236-3p to facilitate the proliferation, migration and invasion of colorectal cancer via regulating MACC1." hsa_circ_0101802 - circ_0101802 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ_0101802 functioned as a tumor promoter in CRC, which could facilitate CRC proliferation, migration and invasion via regulating the miR-1236-3p/MACC1 axis." 3 Circular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma. hsa_circ_0005986 hsa_circ_PRDM2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated "High hsa_circ_0005986 expression was associated with improved survival and was an independent prognostic factor for overall [hazard ratio (HR), 0.572; 95% CI, 0.339-0.966; p = 0.037] and progression-free (HR, 0.573; 95% CI, 0.362-0.906; p = 0.017) survival." 2 "Circ-RBMS1 Knockdown Alleviates CSE-Induced Apoptosis, Inflammation and Oxidative Stress via Up-Regulating FBXO11 Through miR-197-3p in 16HBE Cells." - hsa_circ_RBMS1 Circ-RBMS1 DOID:3083 chronic obstructive pulmonary disease chronic obstructive pulmonary disease RT-qPCR up-regulated "Circ-RBMS1 knockdown alleviated CSE-induced apoptosis, inflammation and oxidative stress in 16HBE cells via miR-197-3p/FBXO11 axis, suggesting a new insight into the pathogenesis of CS-induced COPD." 1 Circular RNA circ-MMP11 Contributes to Lapatinib Resistance of Breast Cancer Cells by Regulating the miR-153-3p/ANLN Axis. - hsa_circ_MMP11 Circ-MMP11 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ-MMP11 could be transferred by exosomes in breast cancer cells. And circ-MMP11 functioned as a sponge of miR-153-3p to regulate ANLN expression, thereby promoting lapatinib resistance in breast cancer cells, providing therapeutic targets for the treatment of breast cancer." 4 Circular RNA TADA2A promotes proliferation and migration via modulating of miR_638/KIAA0101 signal in non_small cell lung cancer. - hsa_circ_TADA2A circTADA2A DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circTADA2A promoted NSCLC cell proliferation and migration via modulating miR_638/KIAA0101 signaling. 6 CircTMC5 promotes gastric cancer progression and metastasis by targeting miR-361-3p/RABL6. - hsa_circ_TMC5 CircTMC5 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "CircTMC5 promotes GC and sponges miR-361-3p to up-regulate RABL6 expression, thus may have diagnostic and prognostic value in GC. RABL6 also displays therapeutic promise due to its role in the immune regulation of GC." 1 Circular RNA circ_0046264 Suppresses Osteosarcoma Progression via microRNA-940/Secreted Frizzled Related Protein 1 Axis. hsa_circ_0046264 - circ_0046264 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" down-regulated circ_0046264 is a tumor suppressor to inhibit the osteosarcoma progression via modulating the miR-940 / SFRP1 axis. 1 The Maturation of Tumor Suppressor miR-497 in Hepatocellular Carcinoma is Inhibited by Oncogenic circRNA SCARB1. - hsa_circ_SCARB1 circRNA SCARB1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circRNA SCARB1 is upregulated in HCC and promotes HCC cell proliferation and migration by suppressing the maturation of miR-497. 1 circRNA_103615 contributes to tumor progression and cisplatin resistance in NSCLC by regulating ABCB1. - - circRNA_103615 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circRNA_103615 contributes to tumor progression and cisplatin resistance in NSCLC by regulating ABCB1. 1 Circular RNA circNEURL4 inhibits cell proliferation and invasion of papillary thyroid carcinoma by sponging miR-1278 and regulating LATS1 expression. - hsa_circ_NEURL4 circNEURL4 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" down-regulated circNEURL4 may probably serve as a diagnostic marker to predict PTC patients prognosis and a possible therapeutic target to PTC via miR-1278/LATS1 axis. 1 Hsa_circRNA_100146 Promotes Prostate Cancer Progression by Upregulating TRIP13 via Sponging miR-615-5p. - - circRNA_100146 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "CircRNA_100146 is a tumor promoter in PCa, which promoted progression by mediating the miR-615-5p/TRIP13." 1 Circular RNA circ_0000228 promotes the malignancy of cervical cancer via microRNA-195-5p/ lysyl oxidase-like protein 2 axis. hsa_circ_0000228 - circ_0000228 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circ_0000228 is an oncogenic circRNA, which participates in promoting CC progression via regulating the miR-195-5p/LOXL2 axis." 2 Human circular RNA hsa_circRNA_101705 (circTXNDC11) regulates renal cancer progression by regulating MAPK/ERK pathway. - hsa_circ_TXNDC11 hsa_circRNA_101705 DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated circTXNDC11 promoted RCC growth and invasion by activating the MAPK/ERK pathway. 1 Circ_0089823 reinforces malignant behaviors of non-small cell lung cancer by acting as a sponge for microRNAs targeting SOX4(). hsa_circ_0089823 - Circ_0089823 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RNA-seq up-regulated "circ_0089823 might act as a sponge of microRNAs targeting SOX4, thus increasing the expression of SOX4, thereby reinforcing the malignant behaviors of NSCLC cells." 1 CircPVT1 promotes gallbladder cancer growth by sponging miR-339-3p and regulates MCL-1 expression. - hsa_circ_PVT1 CircPVT1 DOID:3121 gallbladder cancer gallbladder cancer RT-qPCR up-regulated "circPVT1 could regulate Myeloid cell leukemia-1 (MCL-1) expression by sponging to miR-339-3p, which affected tumor progression in GBC cells." 1 CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3. - hsa_circ_WHSC1 circWHSC1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircWHSC1 is an independent indicator of poor prognosis in NSCLC patients, and functions as a ceRNA of miR-296-3p to up-regulate AKT3, consequently promotes NSCLC cell growth and metastasis. Targeting circWHSC1 might be a prospective strategy for diagnosis, therapeutics, and prognosis of NSCLC." 3 Circular RNA circSP3 promotes hepatocellular carcinoma growth by sponging microRNA-198 and upregulating cyclin-dependent kinase 4. - hsa_circ_SP3 circSP3 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Silencing circSP3 inhibited HCC cell proliferation and migration by downregulating cyclin-dependent kinase 4, whereas inhibiting miR-198 reversed those effects." 1 CircRNA UBAP2 serves as a sponge of miR-1294 to increase tumorigenesis in hepatocellular carcinoma through regulating c-Myc expression. - hsa_circ_UBAP2 circUBAP2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated CircRNA UBAP2 serves as a sponge of miR-1294 to increase tumorigenesis in hepatocellular carcinoma through regulating c-Myc expression. 4 Overexpression of circRNA circFAT1 in Endometrial Cancer Cells Increases Their Stemness by Upregulating miR-21 Through Methylation. - hsa_circ_FAT1 circFAT1 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated circFAT1 is upregulated in EC and it may increase cancer cell stemness by upregulating miR-21. 1 Circular RNA circEGFR regulates tumor progression via the miR-106a-5p/DDX5 axis in colorectal cancer. - hsa_circ_EGFR circEGFR DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circEGFR promoted CRC cell proliferation, migration, and invasion through the miR-106a-5p/DDX5/AKT axis, and may serve as a promising diagnostic marker and therapeutic target for CRC patients." 1 Hsa_circ_0136666 activates Treg-mediated immune escape of colorectal cancer via miR-497/PD-L1 pathway. hsa_circ_0136666 - - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "hsa_circ_0136666 promoted the expression of PD-L1 by inhibiting miR-497 level in colorectal cancer, thus inducing the activation of Treg cells and leading to the immune escape of tumor, providing a novel mechanistic insight into the pathogenesis of colorectal cancer." 3 CircSCAP Aggravates Oxidized Low-density Lipoprotein-induced Macrophage Injury by Upregulating PDE3B by miR-221-5p in Atherosclerosis. - hsa_circ_SCAP circSCAP DOID:1936 atherosclerosis Atherosclerosis RT-qPCR up-regulated "In conclusion, circSCAP facilitated lipid accumulation, inflammation, and oxidative stress in ox-LDL-induced THP-1 macrophages by regulating miR-221-5p/PDE3B axis." 1 Circular RNA TAF4B Promotes Bladder Cancer Progression by Sponging miR-1298-5p and Regulating TGFA Expression. - hsa_circ_TAF4B circTAF4B DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circTAF4B played a carcinogenic role in the growth, metastasis, and EMT process of BCa by regulating the miR-1298-5p/TGFA axis." 1 Circ_0007031 Silencing Inhibits Cell Proliferation and Induces Cell Apoptosis via Downregulating MELK at a miR-485-3p-Dependent Way in Colorectal Cancer. hsa_circ_0007031 - Circ_0007031 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0007031 knockdown repressed CRC malignant progression by reducing MELK expression through associating with miR-485-3p, suggesting that circ_0007031 was a potential target for the therapy of CRC." 4 circZFR regulates thyroid cancer progression by the miR-16/MAPK1 axis. - hsa_circ_ZFR circZFR DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated circZFR knockdown retarded TC progression by sponging miR-16 and modulating MAPK1 expression. 1 Circ_0008673 regulates breast cancer malignancy by miR-153-3p/CFL2 axis. hsa_circ_0008673 - Circ_0008673 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0008673 promoted breast cancer progression by upregulating CFL2 expression through sponging miR-153-3p. 2 Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis. hsa_circ_0000520 - Circ_0000520 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated Circ_0000520 contributed to TNBC development by binding to miR-1296 to induce ZFX expression. 1 The circular RNA circTXNRD1 promoted ambient particulate matter-induced inflammation in human bronchial epithelial cells by regulating miR-892a/COX-2 axis. - hsa_circ_TXNRD1 circTXNRD1 DOID:0080809 chronic asthma chronic airway diseases "RT-qPCR, microarray" up-regulated circTXNRD1 as a novel inflammatory mediator in PM-induced inflammation in HBECs via regulating miR-892a/COX-2 axis. These results provide new insight into the biological mechanism underlying PM-induced inflammation in chronic airway diseases. 1 CircRNA circ_SEC24A upregulates DNMT3A expression by sponging miR-26b-5p to aggravate osteoarthritis progression. hsa_circ_0005105 hsa_circ_SEC24A circ_SEC24A DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Circ_SEC24A was a promoting factor for IL-1beta-induced OA progression via circ_SEC24A/miR-26b-5p/DNMT3A ceRNA axis. 3 Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis. hsa_circ_0003972 - circ_0003972 DOID:848 arthritis arthritis RT-qPCR up-regulated Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4. 2 Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-kappaB/bone remodeling factors signaling. - hsa_circ_IKBKB circIKBKB DOID:1612 breast cancer breast cancer bone metastasis "RT-qPCR, RNA-seq" up-regulated Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-kappaB/bone remodeling factors signaling. 1 CircSPIDR acts as a tumour suppressor in cervical adenocarcinoma by sponging miR-431-5p and regulating SORCS1 and CUBN expression. - hsa_circ_SPIDR CircSPIDR DOID:3702 cervical adenocarcinoma cervical adenocarcinoma "RT-qPCR, RNA-seq" down-regulated "circSPIDR suppresses cervical adenocarcinoma by competitively binding to miR-431-5p, thus upregulating SORCS1 and CUBN." 1 CircN4BP2L2 promotes colorectal cancer growth and metastasis through regulation of the miR-340-5p/CXCR4 axis. - hsa_circ_N4BP2L2 CircN4BP2L2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Our data indicated an oncogenic role of circN4BP2L2 in CRC via regulation of the miR-340-5p/CXCR4 axis, which may be a promising biomarker and target for CRC treatment." 1 CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis. - hsa_circ_FOXK2 circFOXK2 DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated "circFOXK2 functions as a key regulator in BC metastasis, and the role of circFOXK2 on BC metastasis is tightly associated with the involvement of IGF2BP3 and miR-370." 1 Circ_0025908 regulates cell vitality and proliferation via miR-137/HIPK2 axis of rheumatic arthritis. hsa_circ_0025908 - Circ_0025908 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "Circ_0025908 facilitates the development of RA through increasing HIPK2 expression by regulating miR-137, which also offered an underlying targeted therapy for RA treatment." 2 Knockdown of Circular RNA hsa_circ_PVT1 Inhibited Laryngeal Cancer Progression via Preventing wnt4/beta-Catenin Signaling Pathway Activation. - hsa_circ_PVT1 - DOID:2600 laryngeal carcinoma laryngeal cancer "RT-qPCR, microarray" up-regulated "Knockdown of circ_PVT1 prevented LC progression via targeting miR-21-5p/CBX4 by inhibiting wnt4/beta-catenin signal pathway, which could provide a novel therapeutic target for LC." 1 Hsa_circ_0016788 regulates hepatocellular carcinoma progression via miR-506-3p/poly-adenosine diphosphate-ribose polymerase. hsa_circ_0016788 hsa_circ_TRIM11 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Hsa_circ_0016788 facilitates the development of HCC through increasing PARP14 expression by regulating miR-506-3p, which also offered an underlying targeted therapy for HCC treatment." 2 Knockdown of circ_0001883 may inhibit epithelial-mesenchymal transition in laryngeal squamous cell carcinoma via the miR-125-5p/PI3K/AKT axis. hsa_circ_0001883 - circ_0001883 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated Knockdown of circ_0001883 may inhibit epithelial-mesenchymal transition in laryngeal squamous cell carcinoma via the miR-125-5p/PI3K/AKT axis. 1 Inhibition of circular RNA_0000285 prevents cell proliferation and induces apoptosis in thyroid cancer by sponging microRNA-654-3p. hsa_circ_0000285 - circRNA_0000285 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated Inhibition of circular RNA_0000285 prevents cell proliferation and induces apoptosis in thyroid cancer by sponging microRNA-654-3p. 3 "Emerging roles of circUBAP2 targeting miR-370-3p in proliferation, apoptosis, and invasion of papillary thyroid cancer cells." - hsa_circ_UBAP2 circUBAP2 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated CircUBAP2 knockdown impeded the proliferation and invasion and induced apoptosis in TC cells via sponging miR-370-3p. 1 Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis. - hsa_circ_CDK14 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circ_CDK14 could sponge miR-520a-3p. miR-520a-3p targeted GAB1 to repress OS cell proliferation and metastasis. Circ_CDK14 knockdown blocked OS tumor growth in vivo. Circ_CDK14 might positively affect OS development by modulating the miR-520a-3p/GAB1 axis. 5 "CircFAM13B promotes the proliferation of hepatocellular carcinoma by sponging miR-212, upregulating E2F5 expression and activating the P53 pathway." - hsa_circ_FAM13B CircFAM13B DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircFAM13B promotes the proliferation of hepatocellular carcinoma by sponging miR-212, upregulating E2F5 expression and activating the P53 pathway." 2 Blocking circ-SCMH1 (hsa_circ_0011946) suppresses acquired DDP resistance of oral squamous cell carcinoma (OSCC) cells both in vitro and in vivo by sponging miR-338-3p and regulating LIN28B. hsa_circ_0011946 hsa_circ_SCMH1 circ-SCMH1 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated Circ-SCMH1 contributes to chemoresistance of DDP-resistant OSCC cells partially via EVs secretion and circ-SCMH1/miR-338-3p/LIN28B axis. 3 circEVI5 acts as a miR-4793-3p sponge to suppress the proliferation of gastric cancer. - hsa_circ_EVI5 circEVI5 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "circEVI5 can bind miR-4793-3p as a ceRNA to eliminate the negative regulation of FOXO1, therefore suppressing GC proliferation." 1 Circ_CLIP2 promotes glioma progression through targeting the miR-195-5p/HMGB3 axis. - hsa_circ_CLIP2 Circ_CLIP2 DOID:0060108 brain glioma glioma RT-qPCR up-regulated Knockdown of Circ_CLIP2 suppresses glioma progression by targeting miR-195-5p/HMGB3 thus inhibiting Wnt/beta-catenin signaling. This study may provide potential therapeutic targets against glioma. 3 CircCNIH4 inhibits gastric cancer progression via regulating DKK2 and FRZB expression and Wnt/beta-catenin pathway. hsa_circ_0000190 hsa_circ_CNIH4 CircCNIH4 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Our study demonstrated that circCNIH4 played a tumor-inhibiting role through upregulating DKK2 and FRZB expression and suppressing Wnt/beta-catenin pathway in gastric cancer, which might provide a potential biomarker for the diagnosis and treatment of gastric cancer." 3 Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation. hsa_circ_0007813 hsa_circ_DHTKD1 - DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation. 2 Circular RNA Circ_0013958 Functions as a Tumor Promoter in Ovarian Cancer by Regulating miR-637/PLXNB2 Axis. hsa_circ_0013958 - Circ_0013958 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Circ_0013958 knockdown impeded OC development through modulating the miR-637/PLXNB2 axis, highlighting a therapeutic target for OC." 2 "circCD151 promotes GLI2 expression by regulating miR_30d_5p and enhancing proliferation, invasion and stemness of lung cancer." - hsa_circ_CD151 circCD151 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated circCD151 could promote the malignant proliferation of lung adenocarcinoma by targeting miR_30d_5p and upregulating GLI2 expression. 1 CircTHBS1 facilitates the progression of interstitial cystitis depending on the regulation of miR-139-5p/MFN2 axis. - hsa_circ_THBS1 CircTHBS1 DOID:13949 interstitial cystitis interstitial cystitis RT-qPCR up-regulated "circTHBS1 sponged miR-139-5p to positively regulate MFN2. CircTHBS1 promoted IC cell proliferation, migration, EMT process, and inflammation by regulating the miR-139-5p/MFN2 axis indicating that circTHBS1 might be a potential target for IC treatment." 1 "Knockdown circ_0040414 inhibits inflammation, apoptosis and promotes the proliferation of cardiomyocytes via miR-186-5p/PTEN/AKT axis in chronic heart failure." hsa_circ_0040414 - circ_0040414 DOID:114 heart disease chronic heart failure RT-qPCR up-regulated "Knockdown circ_0040414 inhibits inflammation, apoptosis and promotes the proliferation of cardiomyocytes via miR-186-5p/PTEN/AKT axis in chronic heart failure." 2 Circular RNA circ_0011385 promotes cervical cancer progression through competitively binding to miR-149-5p and up-regulating SOX4 expression. hsa_circ_0011385 - circ_0011385 DOID:4362 cervical cancer cervical cancer "RT-qPCR, microarray" up-regulated "Circ_0011385 elevates SOX4 expression by targeting miR-149-5p, thus participating in promoting the malignant biological behaviors of CC cells." 2 Circ_USP36 Silencing Attenuates Oxidized Low-Density Lipoprotein-Induced Dysfunction in Endothelial Cells in Atherosclerosis Through Mediating miR-197-3p/ROBO1 Axis. hsa_circ_0003204 hsa_circ_USP36 circ_USP36 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated circ_USP36 interference alleviated ox-LDL-induced dysfunction in HUVECs by targeting miR-197-3p/ROBO1 axis. 7 CircRNA_0043691 sponges miR-873-3p to promote metastasis of gastric cancer. hsa_circ_0043691 - CircRNA_0043691 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Knockdown of circRNA_0043691 delayed the progression of GC via modulating the miR-873-3p-GART axis. 2 Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis. hsa_circ_0007766 hsa_circ_ERBB2 circ-ERBB2 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "circ-ERBB2 facilitated the Warburg effect and malignancy of TNBC cells by the miR-136-5p/PDK4 pathway, at least in part." 1 Upregulated circRNA_102231 promotes gastric cancer progression and its clinical significance. - - circRNA_102231 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "CircRNA_102231 was able to bind to IRTKS, increasing IRTKS protein stability, leading to GC progression. Overexpression of IRTKS effectively rescued the reduced cell viability and invasion caused by silencing of circRNA_102231. " 1 CircTMCO3 Promotes Gastric Cancer Progression by Regulating miR-577/RAB14 Axis. - hsa_circ_TMCO3 CircTMCO3 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circTMCO3 accelerated the growth and migration of GC cells by regulating miR-577/RAB14 axis. 1 CircFAM120B Blocks the Development of Colorectal Cancer by Activating TGF-Beta Receptor II Expression via Targeting miR-645. - hsa_circ_FAM120B CircFAM120B DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated circFAM120B activated the expression of TGFBR2 by targeting miR-645. TGFBR2 also blocked tumor growth in vivo by targeting the miR-645/TGFBR2 axis. 2 CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability. hsa_circ_0061137 hsa_circ_DIDO1 CircDIDO1 DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated "CircDIDO1 overexpression inhibited while knockdown promoted GC cell proliferation, migration and invasion. CircDIDO1 overexpression suppressed GC growth and metastasis in mouse tumor models. Mechanistically, circDIDO1 encoded a novel 529aa protein that directly interacted with poly ADP-ribose polymerase 1 (PARP1) and inhibited its activity. CircDIDO1 also specifically bound to peroxiredoxin 2 (PRDX2) and promoted RBX1-mediated ubiquitination and degradation of PRDX2, which led to the inactivation of its downstream signaling pathways." 2 The Circular RNA circXPO1 Promotes Tumor Growth via Sponging MicroRNA-23a in Prostate Carcinoma. - hsa_circ_XPO1 circXPO1 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "circXPO1 promotes prostate cancer progression via targeting miR-23a, thus suggesting the circXPO1/miR-23a axis can be used as a potential therapeutic target for prostate cancer treatment." 1 CircCUL2 suppresses retinoblastoma cells by regulating miR-214-5p/E2F2 Axis. - hsa_circ_CUL2 CircCUL2 DOID:768 retinoblastoma retinoblastoma RT-qPCR down-regulated CircCUL2 suppresses retinoblastoma cells by regulating miR-214-5p/E2F2 Axis. 1 Circ_KIAA1199 inhibits MSI1 degradation by targeting miR-34c-5p to drive the malignant cell behaviors and tumor growth of colorectal cancer. - hsa_circ_KIAA1199 Circ_KIAA1199 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_KIAA1199 functioned as an oncogene to drive the malignant development of CRC by activating MSI1 via competitively targeting miR-34c-5p. 3 "CircFOXM1 silencing represses cell proliferation, migration and invasion by regulating miR-515-5p/ADAM10 axis in prostate cancer." - hsa_circ_FOXM1 CircFOXM1 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "CircFOXM1 silencing represses cell proliferation, migration and invasion by regulating miR-515-5p/ADAM10 axis in prostate cancer." 1 Downregulation of circ-SFMBT2 blocks the development of gastric cancer by targeting the miR-885-3p/CHD7 pathway. - hsa_circ_SFMBT2 circ-SFMBT2 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Circ-SFMBT2 downregulation repressed the development of gastric cancer partially by controlling the miR-885-3p/CHD7 axis, which might be a novel strategy to inhibit gastric cancer progression." 4 Circ_0087862 promotes the progression of colorectal cancer by sponging miR-142-3p and up-regulating BACH1 expression. hsa_circ_0087862 - Circ_0087862 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0087862 regulates BACH1 expressions through sponging miR-142-3p, and promotes the proliferation, migration, and invasion of CRC cells." 2 "A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis." - hsa_circ_SMARCA5 circSMARCA5 DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated "A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis." 2 IGF2BP2-modified circular RNA circARHGAP12 promotes cervical cancer progression by interacting m(6)A/FOXM1 manner. hsa_circ_0000231 hsa_circ_ARHGAP12 circARHGAP12 DOID:4362 cervical cancer cervical cancer "RT-qPCR, microarray" up-regulated circARHGAP12 exerted the oncogenic role in cervical cancer progression through m(6)A-dependent IGF2BP2/FOXM1 pathway. 1 CircGNG4 Promotes the Progression of Prostate Cancer by Sponging miR-223 to Enhance EYA3/c-myc Expression. - hsa_circ_GNG4 CircGNG4 DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated the circGNG4/miR-223/EYA3/c-Myc regulatory pathway promoted the malignant progression of prostate cancer. 1 MiR-92b-3p Inhibits Proliferation of HER2-Positive Breast Cancer Cell by Targeting circCDYL. - hsa_circ_CDYL circCDYL DOID:0060079 Her2-receptor positive breast cancer HER2-positive breast cancer RT-qPCR up-regulated "MiR-92b-3p-dependent cleavage of circCDYL was an essential mechanism in regulating cell proliferation of HER2(+) breast cancer cells. CircCDYL was proved to be a potential therapeutic target for HER2(+) breast cancer, and both circCDYL and miR-92b-3p might be potential biomarkers in predicting clinical outcome of HER2(+) breast cancer patients." 1 Knockdown of circNRIP1 sensitizes colorectal cancer to 5_FU via sponging miR_532_3p. - hsa_circ_NRIP1 circNRIP1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "overexpression of circNRIP1 promoted the progression of CRC, while circNRIP1 silencing sensitized CRC cells to 5_FU via sponging miR_532_3p." 2 Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance. hsa_circ_001888 - - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "hsa_circ_001888 was first found to be significantly downregulated in GC cell lines (AGS and MKN-45), tissues, and plasma samples compared to control samples." 1 circRNA RPPH1 Facilitates the Aggravation of Breast Cancer Development by Regulating miR-542-3p/ARHGAP1 Pathway. - hsa_circ_RPPH1 circ_RPPH1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circ_RPPH1 contributed to BC tumorigenesis by sponging miR-542-3p and upregulating ARHGAP1, affording a novel mechanistic pathway in BC development." 9 CircLPAR1/miR-212-3p/ZNF217 feedback loop promotes amyloid beta-induced neuronal injury in Alzheimer Disease. - hsa_circ_LPAR1 circLPAR1 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated "CircLPAR1 promotes Abeta25-35-induced apoptosis, inflammation, and oxidative stress via miR-212-3p/ZNF217 axis, suggesting a new insight into the pathogenesis of AD." 2 Identification of a novel circ_0018289/miR-183-5p/TMED5 regulatory network in cervical cancer development. hsa_circ_0018289 - circ_0018289 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "TMED5 was directly targeted and inhibited by miR-183-5p through the perfect complementary sites in TMED5 3UTR, and TMED5 knockdown phenocopied miR-183-5p overexpression in suppressing cervical cancer development and angiogenesis. Furthermore, circ_0018289 induced TMED5 expression by competitively binding to shared miR-183-5p." 3 "Silencing of circ_0000517 suppresses proliferation, glycolysis, and glutamine decomposition of non-small cell lung cancer by modulating miR-330-5p/YY1 signal pathway." hsa_circ_0000517 - circ_0000517 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated silencing of circ_0000517 improved the progression of NSCLC through regulating miR-330-5p/YY1 axis. 2 CircRNA circ-ATAD1 is downregulated in endometrial cancer and suppresses cell invasion and migration by downregulating miR-10a through methylation. - hsa_circ_ATAD1 circ-ATAD1 DOID:1380 endometrial cancer endometrial cancer RT-qPCR down-regulated Circ-ATAD1 is downregulated in EC and may suppress EC cell invasion and migration by downregulating miR-10a through methylation. 1 Circular RNA circRHOT1 contributes to pathogenesis of non-small cell lung cancer by epigenetically enhancing C-MYC expression through recruiting KAT5. - hsa_circ_RHOT1 circRHOT1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circRHOT1 contributed to pathogenesis of NSCLC by epigenetically enhancing c-MYC expression through recruiting KAT5. 1 CircASAP1 promotes the development of cervical cancer through sponging miR-338-3p to upregulate RPP25. - hsa_circ_ASAP1 CircASAP1 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circASAP1 could function as a sponge for miR-338-3p to increase the expression of RPP25, and further regulated proliferation, migration, invasion, apoptosis, and cell cycle program of cervical cancer cells, which might be potential markers for cervical cancer diagnosis." 1 Circ_0003732 promotes osteosarcoma progression through regulating miR-377-3p/CPEB1 axis and Wnt/beta-catenin signaling pathway. hsa_circ_0003732 - Circ_0003732 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ_0003732 might play a positive role in the malignant progression of osteosarcoma by regulating the miR-377-3p/CPEB1 axis and activating the Wnt/beta-catenin signaling pathway, which might provide new insights for osteosarcoma therapy." 2 Circ_0005875 sponges miR-502-5p to promote renal cell carcinoma progression through upregulating E26 transformation specific-1. hsa_circ_0005875 - Circ_0005875 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated Circ_0005875 knockdown suppressed RCC progression by regulating miR-502-5p/ETS1 axis. 1 Circ-DONSON Facilitates the Malignant Progression of Gastric Cancer Depending on the Regulation of miR-149-5p/LDHA Axis. - hsa_circ_DONSON Circ-DONSON DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circ-DONSON could facilitate GC progression by increasing LDHA expression via sponging miR-149-5p, indicating that circ-DONSON might be a novel biomarker for GC treatment." 3 circ_0005379 inhibits the progression of oral squamous cell carcinoma by regulating the miR-17-5p/acyl-CoA oxidase 1 axis. hsa_circ_0005379 - circ_0005379 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "circ_0005379 may inhibit the proliferation, migration, and invasion of OSCC cells by downregulating the expression of miR-17-5p and upregulating ACOX1, which promote apoptosis and inhibit tumor growth in vivo. circ_0005379 may be a potential target for OSCC treatment." 2 A novel circ_0099999/miR-330-5p/FSCN1 ceRNA crosstalk in pancreatic cancer. hsa_circ_0099999 - circ_0099999 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "Our findings established a novel causal mechanism, circ_0099999/miR-330-5p/FSCN1 ceRNA crosstalk, in regulating pancreatic carcinogenesis and provided that inhibition of circ_0099999 might have therapeutic benefits in pancreatic cancer." 2 Circ_0006174 promotes colorectal cancer progression by sponging microRNA-142-3p and regulating X-linked inhibitor of apoptosis expression. hsa_circ_0006174 - Circ_0006174 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0006174 facilitates colorectal cancer cell proliferation, migration and invasion, and represses colorectal cancer cell apoptosis by regulating microRNA-142-3p/X-linked inhibitor of apoptosis axis." 5 CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis-mediated mitochondrial DNA damage by sponging miR-17-5p. - hsa_circ_TLK1 circTLK1 DOID:0040085 bacterial sepsis sepsis RT-qPCR up-regulated "CircTLK1 sponged miR-17-5p to aggravate mtDNA oxidative damage, mitochondrial dysfunction and cardiomyocyte apoptosis via activating PARP1/HMGB1 axis during sepsis, indicating that circTLK1 may be a putative therapeutic target for septic cardiomyopathy." 1 SNAI2-Induced CircMTO1 Promotes Cell Proliferation and Inhibits Apoptosis Through the miR-320b/MCL1 Axis in Human Granulosa-Like Tumor Cells. - hsa_circ_MTO1 circMTO1 DOID:11612 polycystic ovary syndrome Polycystic ovary syndrome RT-qPCR down-regulated Our results may provide potential targets for PCOS research and a novel direction for the diagnosis and treatment of PCOS. 1 "circRNA hsa_circ_0005909 Predicts Poor Prognosis and Promotes the Growth, Metastasis, and Drug Resistance of Non-Small-Cell Lung Cancer via the miRNA-338-3p/SOX4 Pathway." hsa_circ_0005909 hsa_circ_XPR1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ_0005909 promoted the progression of NSCLC via the modulation of the miRNA-338-3p/SOX4 axis, which may be a therapeutic target for NSCLC." 1 Hsa_circ_0023990 Promotes Tumor Growth and Glycolysis in Dedifferentiated TC via Targeting miR-485-5p/FOXM1 Axis. hsa_circ_0023990 hsa_circ_NOX4 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "Our results discovered the functional network of hsa_circ_0023990 in dedifferentiated TC development by facilitating cell proliferation and glycolysis via miR-485-5p/FOXM1 axis, implying that hsa_circ_0023990 might be a potential therapeutic target for the dedifferentiated TC treatment." 1 Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR_1276/SIRT4 axis. - hsa_circ_OMA1 circOMA1 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated circOMA1 may act as an oncogenic circRNA in BC via regulation of the miR_1276/SIRT4 axis. 1 Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling. - hsa_circ_UBAP2 circUBAP2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circUBAP2 acts as an oncogene via a novel circUBAP2/miR-582-5p/FOXO1 axis. 1 N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. hsa_circ_0079587 hsa_circ_IGF2BP3 circIGF2BP3 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated Our results reveal the function of circIGF2BP3 in causing immune escape from CD8(+) T cell-mediated killing through a decrease in PD-L1 ubiquitination and subsequent proteasomal degradation by stabilizing OTUB1 mRNA in a PKP3-dependent manner. 1 FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma. hsa_circ_0007444 hsa_circ_RHOBTB3 circRHOBTB3 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" up-regulated FUS-mediated circRHOBTB3 functions as a tumor activator to promote PDAC cell proliferation by modulating miR-600/NACC1/Akt/mTOR axis regulated autophagy. 1 Circular RNA CircEYA3 induces energy production to promote pancreatic ductal adenocarcinoma progression through the miR-1294/c-Myc axis. - hsa_circ_EYA3 CircEYA3 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated "Functionally, circEYA3 increased energy production via ATP synthesis to promote PDAC progression in vitro and in vivo. Mechanistically, circEYA3 functions as an endogenous miR-1294 sponge to elevate c-Myc expression, thus exerting its oncogenic functions." 1 Circ_0027089 regulates NACC1 by targeting miR-136-5p to aggravate the development of hepatitis B virus-related hepatocellular carcinoma. hsa_circ_0027089 - Circ_0027089 DOID:684 hepatocellular carcinoma hepatitis B virus-related hepatocellular carcinoma RT-qPCR up-regulated Circ_0027089 functioned as an oncogene to promote the development of HBV-related HCC by regulating NACC1 via competitively targeting miR-136-5p. 2 CircRNA circ-PDCD11 promotes triple-negative breast cancer progression via enhancing aerobic glycolysis. hsa_circ_0019853 hsa_circ_PDCD11 circPDCD11 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, microarray" up-regulated CircRNA circ-PDCD11 promotes triple-negative breast cancer progression via enhancing aerobic glycolysis. 1 Hsa_circ_0026628 promotes the development of colorectal cancer by targeting SP1 to activate the Wnt/beta-catenin pathway. hsa_circ_0026628 hsa_circ_SP1 circ_0026628 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "SOX2-induced circ_0026628 sponged miR-346 and recruited FUS protein to augment SP1, triggering the downstream Wnt/beta-catenin pathway to facilitate CRC progression." 1 "Circ_0084582 Facilitates Cell Growth, Migration, Invasion, and Angiopoiesis in Osteosarcoma via Mediating the miR-485-3p/JAG1 Axis." hsa_circ_0084582 - Circ_0084582 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circ_0084582 functions as a tumorigenic factor in OS via the regulation of miR-485-3p/JAG1 axis. 1 Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis. hsa_circ_0003972 hsa_circ_FAM120A circ-FAM120A DOID:848 arthritis arthritis RT-qPCR up-regulated "Paeoniflorin inhibited RA-FLS proliferation, mobility, and inflammation and triggered cell cycle arrest via mediating the circ-FAM120A/miR-671-5p/MDM4 pathway." 2 Hsa_circ_0001020 Serves as a Potential Biomarker for Gastric Cancer Screening and Prognosis. hsa_circ_0001020 hsa_circ_UGP2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circ_0001020 was significantly upregulated in GC cell lines, GC tissue samples, and even in plasma." 1 Circular RNA HECTD1 Mitigates Ulcerative Colitis by Promoting Enterocyte Autophagy Via miR-182-5p/HuR Axis. - hsa_circ_HECTD1 - DOID:8577 ulcerative colitis ulcerative colitis RT-qPCR down-regulated Overexpression of circHECTD1 alleviates UC by promoting HuR-dependent autophagy via miR-182_5p. This study highlights the therapeutic potential of circHECTD1 for UC and adds to the knowledge of circRNA in the pathogenesis of UC. 1 The Diagnostic Value of Serum Exosomal Has_circ_0000615 for Breast Cancer Patients. hsa_circ_0000615 hsa_circ_ZNF609 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated the expression of has_circ_0000615 was detected in the exosomes and its expression level was markedly upregulated in breast cancer cell lines compared with normal ductal epithelial cells. 2 A Cytoplasm-Enriched circRNA circ-MYBL2 is Downregulated in Non-Small Cell Lung Cancer and Sponges Oncogenic miR-28 to Regulate Cancer Cell Proliferation and Apoptosis. - hsa_circ_MYBL2 circ-MYBL2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "Circ-MYBL2 is enriched in cytoplasm, and it sponges oncogenic miR-28 to suppress cancer cell proliferation in NSCLC and promote cell apoptosis." 1 Circular RNA SLC26A4 regulates the maturation of microRNA-15a in non-small cell lung cancer cells. - hsa_circ_SLC26A4 circSLC26A4 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circSLC26A4 may suppress the maturation of miR-15a in NSCLC to inhibit cancer cell proliferation. 1 "Circ-Sirt1 inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes." - hsa_circ_Sirt1 circ-Sirt1 DOID:848 arthritis arthritis RT-qPCR up-regulated "In conclusion, the protective effect of Circ-Sirt1 on MH7A depends on inhibiting cell proliferation, promoting apoptosis and miR-132-mediated Sirt1 pathway to reduce inflammation." 1 Mediation of circ_RPPH1 on miR-146b-3p/E2F2 pathway to hinder the growth and metastasis of breast carcinoma cells. - hsa_circ_RPPH1 - DOID:3459 breast carcinoma breast carcinoma RT-qPCR up-regulated Circ_RPPH1/miR-146b-3p/E2F2 axis can promote the progression of BC. 1 hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527. hsa_circ_0003222 hsa_circ_LARP4 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527. 4 Hsa_circ_0006232 promotes laryngeal squamous cell cancer progression through FUS-mediated EZH2 stabilization. hsa_circ_0006232 hsa_circ_TRERF1 circ_0006232 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell cancer RT-qPCR up-regulated "Hsa_circ_0006232 promotes proliferation, migration and invasion of LSCC cells, and accelerates tumor growth of LSCC through FUS-mediated EZH2 stabilization." 1 Circ_RASGEF1B Promotes LPS-Induced Apoptosis and Inflammatory Response by Targeting MicroRNA-146a-5p/Pdk1 Axis in Septic Acute Kidney Injury Cell Model. - hsa_circ_RASGEF1B circ_RASGEF1B DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated Circ_RASGEF1B promoted LPS-induced apoptosis and inflammatory response in renal tubular epithelial cells partly by upregulating Pdk1 via acting as miR-146a-5p sponge. 1 Hsa_circ_0040809 regulates colorectal cancer development by upregulating methyltransferase DNMT1 via targeting miR-515-5p. hsa_circ_0040809 hsa_circ_BANP circ_0040809 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "circ_0040809 facilitates CRC cell proliferation and migration, and inhibits apoptosis, through modulating miR-515-5p/DNMT1 axis." 3 Circ_0057558 promotes nonalcoholic fatty liver disease by regulating ROCK1/AMPK signaling through targeting miR-206. hsa_circ_0057558 - Circ_0057558 DOID:80208 non-alcoholic fatty liver disease nonalcoholic fatty liver disease RT-qPCR up-regulated "Circ_0057558 acts as a miR-206 sponge to de-repress the ROCK1/AMPK signaling and facilitates lipogenesis and TG secretion, which greatly contributes to NAFLD development and progression." 1 circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular carcinoma. hsa_circ_0000384 hsa_circ_MRPS35 circMRPS35 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "knockdown of the expression of circMRPS35 in Huh-7 and HCC-LM3 cells suppressed their proliferation, migration, invasion, clone formation, and cell cycle in vitro, and it suppressed tumor growth in vivo as well. Mechanically, circMRPS35 sponged microRNA-148a-3p (miR-148a), regulating the expression of Syntaxin 3 (STX3), which modulated the ubiquitination and degradation of phosphatase and tensin homolog (PTEN)." 1 circ-EIF6 encodes EIF6-224aa to promote TNBC progression via stabilizing MYH9 and activating the Wnt/beta-catenin pathway. hsa_circ_0060055 hsa_circ_EIF6 circ-EIF6 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, RNA-seq" up-regulated circ-EIF6 encodes EIF6-224aa to promote TNBC progression via stabilizing MYH9 and activating the Wnt/beta-catenin pathway. 1 Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK. - hsa_circ_GALNT16 Circ-GALNT16 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" down-regulated Circ-GALNT16 suppressed CRC progression by inhibiting Serpine1 expression through regulating the sequence-specific DNA binding ability of the SENP2-mediated hnRNPK-p53 transcriptional complex and might function as a biomarker and therapeutic target for CRC. 1 Circ_0062270 upregulates EPHA2 to facilitate melanoma progression via sponging miR-331-3p. hsa_circ_0062270 - Circ_0062270 DOID:1909 melanoma melanoma RT-qPCR up-regulated "Circ_0062270 accelerated the progression of melanoma through regulating the miR-331-3p/EPHA2 axis, suggesting that circ_0062270 might be a novel potential therapeutic target for melanoma." 2 A novel circular RNA circPPFIA1 promotes laryngeal squamous cell carcinoma progression through sponging miR-340-3p and regulating ELK1 expression. - hsa_circ_PPFIA1 circPPFIA1 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated A novel circular RNA circPPFIA1 promotes laryngeal squamous cell carcinoma progression through sponging miR-340-3p and regulating ELK1 expression. 1 CircRNA circPTK2 Might Suppress Cancer Cell Invasion and Migration of Glioblastoma by Inhibiting miR-23a Maturation. - hsa_circ_PTK2 circPTK2 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated CircPTK2 might suppress cancer cell invasion and migration by inhibiting the maturation of miR-23a. 2 CircRNA DUSP16 Knockdown Suppresses Colorectal Cancer Progression by Regulating the miR-432-5p/E2F6 Axis. - hsa_circ_DUSP16 circDUSP16 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circDUSP16 knockdown suppressed CRC progression by regulating the miR-432-5p/E2F6 axis, suggesting that the circDUSP16/miR-432-5p/E2F6 network may be a potential therapeutic target for CRC." 1 Circ_0074027 binds to EIF4A3 and promotes gastric cancer progression. hsa_circ_0074027 - Circ_0074027 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_0074027 binds to EIF4A3 and promotes gastric cancer progression. 1 CircSEC24A promotes tumor progression through sequestering miR-455-3p in hepatocellular carcinoma. - hsa_circ_SEC24A CircSEC24A DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "circSEC24A sponged miR-455-3p to elevate the PPM1F expression, resulting in accelerating malignant behaviors of HCC cells." 4 Circular noncoding RNA circ_0007334 sequestrates miR-577 to derepress KLF12 and accelerate colorectal cancer progression. hsa_circ_0007334 - circ_0007334 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ_0007334 deficiency exerts a tumor-suppressor by the miR-577/KLF12 axis in CRC, and indicated that exosomal circ_0007334 could hinder CRC tumor growth and angiogenesis in vivo." 1 Circular RNA circ_0000592 elevates ANXA4 expression via sponging miR-1179 to facilitate tumor progression in gastric cancer. hsa_circ_0000592 - circ_0000592 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circular RNA circ_0000592 elevates ANXA4 expression via sponging miR-1179 to facilitate tumor progression in gastric cancer. 2 CircAGFG1 acts as a sponge of miR-4306 to stimulate esophageal cancer progression by modulating MAPRE2 expression. - hsa_circ_AGFG1 CircAGFG1 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated CircAGFG1 acts as a sponge of miR-4306 to stimulate esophageal cancer progression by modulating MAPRE2 expression. 1 Circ-RNF111 aggravates the malignancy of gastric cancer through miR-876-3p-dependent regulation of KLF12. - hsa_circ_RNF111 Circ-RNF111 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ-RNF111 knockdown relieved the development of GC by regulating miR-876-3p/KLF12 axis. 1 "Circular RNA circ_0008360 Inhibits the Proliferation, Migration, and Inflammation and Promotes Apoptosis of Fibroblast-Like Synoviocytes by Regulating miR-135b-5p/HDAC4 Axis in Rheumatoid Arthritis." hsa_circ_0008360 - circ_0008360 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR down-regulated "Circ_0008360 inhibited the proliferation, migration, and inflammation and facilitated apoptosis of RA-FLSs by sponging miR-135b-5p and upregulating HDAC4." 2 EIF4A3-mediated hsa_circ_0088088 promotes the carcinogenesis of breast cancer by sponging miR-135-5p. hsa_circ_0088088 hsa_circ_HSDL2 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated EIF4A3-induced hsa_circ_0088088 stimulates the carcinogenic effects of breast tumors by sponging miR-135-5p. 2 CircLNPEP promotes the progression of ovarian cancer through regulating miR-876-3p/ WNT5A axis. - hsa_circ_LNPEP CircLNPEP DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "CircLNPEP promoted cancer cell proliferation, EMT and angiogenesis, and inhibited apoptosis by regulating miR-876-3p/WNT5A axis." 1 Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2. - hsa_circ_RNF13 circRNF13 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, RNA-seq" down-regulated Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2. 2 Circ-E2F3 promotes cervical cancer progression by inhibiting microRNA-296-5p and increasing STAT3 nuclear translocation. - hsa_circ_E2F3 Circ-E2F3 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circ-E2F3 induces inhibition of miR-296-5p, which triggers activation and nuclear translocation of STAT3 that then upregulates cyclin D1 expression." 1 Hsa_circ_0060937 accelerates non-small cell lung cancer progression via modulating miR-195-5p/HMGB3 pathway. hsa_circ_0060937 hsa_circ_CYP24A1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0060937 knockdown hindered NSCLC development and glycolysis via regulating miR-195-5p/HMGB3 pathway. 1 circPTPN22 attenuates immune microenvironment of pancreatic cancer via STAT3 acetylation. - hsa_circ_PTPN22 circPTPN22 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated STAT3 acetylation was involved in these effects. circPTPN22 promoted STAT3 acetylation via inhibiting STAT3/SIRT1 interaction. circPTPN22 attenuates pancreatic cancer immune microenvironment by promoting STAT3 acetylation via inhibiting STAT3/SIRT1 interaction. 1 Circular RNA circMMP1 Contributes to the Progression of Glioma Through Regulating TGIF2 Expression by Sponging miR-195-5p. hsa_circ_0024108 hsa_circ_MMP1 circMMP1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated CircMMP1 boosted glioma progression partly by targeting the miR-195-5p/TGIF2 axis. 2 "Circ_0000491 Promotes Apoptosis, Inflammation, Oxidative Stress, and Fibrosis in High Glucose-Induced Mesangial Cells by Regulating miR-455-3p/Hmgb1 Axis." hsa_circ_0000491 - circ_0000491 DOID:9743 diabetic neuropathy Diabetic nephropathy RT-qPCR up-regulated "Circ_0000491 knockdown inhibited HG-induced apoptosis, inflammation, oxidative stress, and fibrosis in SV40-MES13 cells by regulating miR-455-3p/Hmgb1 axis." 1 Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties. hsa_circ_0003420 - circ_0003420 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR down-regulated "Up-regulation of hsa-circ_0003420 expression in LSCs caused redox disorder, inflammation and apoptosis, suggesting that this protein could be used as a target for the treatment AML." 1 Exosomes Derived from ADSCs Attenuate Sepsis-Induced Lung Injury by Delivery of Circ-Fryl and Regulation of the miR-490-3p/SIRT3 Pathway. - mmu_circ_Fryl circ-Fryl DOID:850 lung disease lung injury "RT-qPCR, RNA-seq" up-regulated our results suggest that exosomes derived from ADSCs attenuate sepsis-induced lung injury by delivery of circ-Fryl and regulation of the miR-490-3p/SIRT3 pathway. 1 CircRNA circFADS2 is Downregulated in Endometritis and its Overexpression Promotes miR-643 Maturation in Human Endometrial Epithelial Cells to Suppress Cell Apoptosis. - hsa_circ_FADS2 circFADS2 DOID:1002 endometritis endometritis RT-qPCR down-regulated "CircFADS2 is downregulated in endometritis, and it overexpression promotes miR-643 maturation in HEnEpCs to suppress cell apoptosis." 1 Importance of Circ0009910 in colorectal cancer pathogenesis as a possible regulator of miR-145 and PEAK1. hsa_circ_0009910 - Circ0009910 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "Circ0009910 and PEAK1 were significantly upregulated, while miR-145-5p was decreased in CRC samples compared with adjacent tissues." 1 Circ_0029803 serves as the sponge of miR-216b-5p to promote the progression of colorectal cancer by regulating SKIL expression. hsa_circ_0029803 - Circ_0029803 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0029803 knockdown hindered proliferation, migration, invasion, EMT, and glycolysis and promoted apoptosis in CRC cells by modulating the miR-216b-5p/SKIL axis." 1 The circular RNA circCRIM1 inhibits osteosarcoma progression through sponging miR-513. - hsa_circ_CRIM1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "our data uncovered a significant role of the circCRIM1/miR-513 pathway in the proliferation, migration, and invasion of OS cell lines and suggested that circCRIM1 may serve as a possible therapeutic target for OS treatment." 2 CircRNA_103948 inhibits autophagy in colorectal cancer in a ceRNA manner. - - CircRNA_103948 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated circRNA_103948 knockdown inhibited CRC cell growth by targeting miR-1236-3p/TPT1 axis-mediated autophagy. 1 Knockdown of hsa_circ_0091994 constrains gastric cancer progression by suppressing the miR-324-5p/HMGA1 axis. hsa_circ_0091994 hsa_circ_FLNA cicrRNA_105040 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Hsa_circ_0091994 knockdown inhibited the progression of GC by inhibiting the miR-324-5p/HMGA1 axis. 2 "circCDYL2, Overexpressed in Highly Migratory Colorectal Cancer Cells, Promotes Migration by Binding to Ezrin." - hsa_circ_CDYL2 circCDYL2 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated circCDYL2 promotes CRC migration by binding Ezrin and activating the AKT pathway. 1 CircRNF111 Protects Against Insulin Resistance and Lipid Deposition via Regulating miR-143-3p/IGF2R Axis in Metabolic Syndrome. - hsa_circ_RNF111 circRNF111 DOID:3146 lipid metabolism disorder Metabolic Syndrome RT-qPCR down-regulated CircRNF111 inhibition enhances insulin resistance and lipid deposition in MetS through regulating miR-143-3p-IGF2R cascade. This provides a promising therapeutic approach for MetS. 1 CircCDYL Acts as a Tumor Suppressor in Wilm Tumor by Targeting miR-145-5p. hsa_circ_0008285 hsa_circ_CDYL CircCDYL DOID:2154 nephroblastoma wilms tumor RT-qPCR down-regulated CircCDYL Acts as a Tumor Suppressor in Wilms Tumor by Targeting miR-145-5p. 1 Circbeta-catenin promotes tumor growth and Warburg effect of gallbladder cancer by regulating STMN1 expression. - - Circbeta-catenin DOID:3121 gallbladder cancer gallbladder cancer RT-qPCR up-regulated Circbeta-catenin promotes tumor growth and Warburg effect of gallbladder cancer by regulating STMN1 expression. 1 Circ-ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA-128-3p/ZEB1 axis. - hsa_circ_ABCB10 Circ-ABCB10 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circ-ABCB10 depletion inhibits proliferation, invasion and EMT and promotes apoptosis of cervical cancer cells through miR-128-3p/ZEB1 axis and represses CC tumor growth." 1 Circ-PGC increases the expression of FOXR2 by targeting miR-532-3p to promote the development of non-small cell lung cancer. - hsa_circ_PGC Circ-PGC DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ-PGC positively regulated FOXR2 expression by competitively binding to miR-532-3p, thereby promoting the development of NSCLC, and the Wnt/beta-catenin signaling pathway might be activated by the circ-PGC/miR-532-3p/FOXR2 network." 1 CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner. - hsa_circ_MYH9 CircMYH9 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "The overexpression of circMYH9 promotes CRC proliferation though modulating serine/glycine metabolism and redox homeostasis in a p53-dependent manner, and targeting circMYH9 and its pathway may be an effective strategy for the treatment of CRC." 1 circFLNA promotes glioblastoma proliferation and invasion by negatively regulating miR_199_3p expression. - hsa_circ_FLNA circFLNA DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated circFLNA promotes glioblastoma proliferation and invasion by negatively regulating miR_199_3p expression. 1 "A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82." - hsa_circ_GNG7 circGNG7 DOID:5520 head and neck squamous cell carcinoma head and neck squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82." 1 Circ-UQCRC2 aggravates lipopolysaccharide-induced injury in human bronchial epithelioid cells via targeting miR-495-3p/MYD88-mediated inflammatory response and oxidative stress. hsa_circ_0038467 hsa_circ_UQCRC2 circ-UQCRC2 DOID:552 pneumonia pneumonia RT-qPCR up-regulated "In conclusion, circ-UQCRC2 contributed to LPS-induced injury of 16HBE cells by targeting miR-495-3p/MYD88 signalling-mediated inflammatory response and oxidative stress." 4 The circular RNA circ0005654 interacts with specificity protein 1 via microRNA-363 sequestration to promote gastric cancer progression. hsa_circ_0005654 - circ0005654 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circ0005654 expedites the GC development via miR-363/sp1/myc/Wnt/beta-catenin axis and is a new biomarker for GC treatment regimen. 2 Suppression of circ_0008932 inhibits tumor growth and metastasis in osteosarcoma by targeting miR-145-5p. hsa_circ_0008932 - circ_0008932 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circ_0008932 may be a novel oncogenic factor during the progression and development of OS by targeting miR-145-5p. 1 "circASS1 overexpression inhibits the proliferation, invasion and migration of colorectal cancer cells by regulating the miR-1269a/VASH1 axis." - hsa_circ_ASS1 circASS1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "circASS1 overexpression inhibited CRC cell proliferation, invasion and migration by regulating miR-1269a/VASH1, which indicated a potential molecular mechanism underlying the pathogenesis of CRC." 1 CircITGA7 Suppresses Gastric Cancer Progression Through miR-1471/MTDH Axis. - hsa_circ_ITGA7 CircITGA7 DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated CircITGA7 Suppresses Gastric Cancer Progression Through miR-1471/MTDH Axis. 1 Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis. hsa_circ_0001361 hsa_circ_FNDC3B circ_0001361 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated circ_0001361 facilitates the tumorigenesis and development of LUAD through miR-525-5p/VMA21 axis. 1 Hsa_circ_0004712 downregulation attenuates ovarian cancer malignant development by targeting the miR-331-3p/FZD4 pathway. hsa_circ_0004712 hsa_circ_PDE7B - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "hsa_circ_0004712 deficiency repressed OC development by mediating the miR-331-3p/FZD4 pathway, predicting that hsa_circ_0004712 was a promising biomarker for OC diagnosis and therapy." 1 Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription. hsa_circ_0050898 hsa_circ_ACTN4 circACTN4 DOID:4928 intrahepatic cholangiocarcinoma Intrahepatic cholangiocarcinoma "RT-qPCR, microarray" up-regulated "Hsa_circ_0050898, which originated from exon 1 to exon 20 of the ACTN4 gene (named circACTN4), was significantly upregulated in ICC. High circACTN4 expression was associated with enhanced tumor proliferation and metastasis in vitro and in vivo, as well as a worse prognosis following ICC resection." 1 Up-regulation of circARF3 reduces blood-brain barrier damage in rat subarachnoid hemorrhage model via miR-31-5p/MyD88/NF-kappaB axis. - hsa_circ_ARF3 circARF3 DOID:178 vascular disease subarachnoid hemorrhage RT-qPCR down-regulated CircARF3 attenuates BBB destruction in SAH rats by regulating the miR-31-5p-activated MyD88-NF-¦ĘB pathway. 1 A Preliminary Study on the Pathogenesis of Colorectal Cancer by Constructing a Hsa-circRNA-0067835-miRNA-mRNA Regulatory Network. hsa_circ_0067835 hsa_circ_IFT80 circIFT80 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "circIFT80 was up-regulated in CRC tissues. The circIFT80 was able to inhibit apoptosis and promote proliferation, migration and invasion. Moreover, circIFT80 inhibited the expression of hsa-miR-370-3p and promoted the expression of COL6A6, RCBTB1, SLC1A5 and WNT7B in CRC cell lines." 3 circTADA2A Retards the Progression of Colorectal Cancer via Regulating miR-1229/BCL2L10 Signal Axis. - hsa_circ_TADA2A circTADA2A DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated circTADA2A suppressed cell proliferation and migration in CRC through regulation of miR-1229/BCL2L10 axis. 3 Circular RNA hsa_circ_0006117 Facilitates Pancreatic Cancer Progression by Regulating the miR-96-5p/KRAS/MAPK Signaling Pathway. hsa_circ_0006117 hsa_circ_PTPRA - DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated specifically highly expressed circular RNA hsa_circ_0006117 facilitates PC progression via the modulation of the miR-96-5p/KRAS/MAPK signaling pathway and might be a hopeful therapeutic target for PC. 1 hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3. hsa_circ_0068631 hsa_circ_TFRC - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3. 1 Circular RNA FOXP1 Induced by ZNF263 Upregulates U2AF2 Expression to Accelerate Renal Cell Carcinoma Tumorigenesis and Warburg Effect through Sponging miR-423-5p. - hsa_circ_FOXP1 circFOXP1 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated Circular RNA FOXP1 Induced by ZNF263 Upregulates U2AF2 Expression to Accelerate Renal Cell Carcinoma Tumorigenesis and Warburg Effect through Sponging miR-423-5p. 1 Hsa_circ_0009128 mediates progression of oral squamous cell carcinoma by influencing MMP9. hsa_circ_0009128 hsa_circ_TXNDC11 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated The circRNA hsa_circ_0009128 correlates with malignant progression of OSCC. Hsa_circ_0009128 stimulates proliferation and migration in OSCC cells by targeting MMP9 to activate EMT. 1 Circular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells. hsa_circ_0075542 hsa_circ_F13A1 - DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated hsa_circ_0075542 suppressed malignant characteristics and promoted apoptosis in LNCaP and PC3 cells by acting as a competing endogenous RNA of miR-1197. The hsa_circ_0075542/miR-1197 axis might play a role via HOXC11. 1 CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer. - hsa_circ_TUBGCP3 CircTUBGCP3 DOID:1993 rectum cancer rectal cancer RT-qPCR up-regulated CircTUBGCP3 acted as an oncogene to promote the malignant phenotypes of rectal cancer cells by modulating miR-375/ROCK1 axis. 1 Circular RNA circ_0089153 acts as a competing endogenous RNA to regulate colorectal cancer development by the miR-198/SUMO-specific peptidase 1 (SENP1) axis. hsa_circ_0089153 - circ_0089153 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circ_0089153 as a novel regulator of CRC development through the regulation of the miR-198/SENP1 axis and establish a strong rationale for developing circ_0089153 as a promising therapeutic against CRC. 1 "Circ_0010283/miR-377-3p/Cyclin D1 Axis Is Associated With Proliferation, Apoptosis, Migration, and Inflammation of Oxidized Low-density Lipoprotein-Stimulated Vascular Smooth Muscle Cells." hsa_circ_0010283 - Circ_0010283 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Circ_0010283 regulated proliferation, apoptosis, migration, and inflammation of ox-LDL-stimulated VSMCs through modulating miR-377-3p and CCND1." 3 Overexpression of hsa_circ_0022742 suppressed hyperglycemia-induced endothelial dysfunction by targeting the miR-503-5p/FBXW7 axis. hsa_circ_0022742 - - DOID:9351 diabetes mellitus diabetes RT-qPCR down-regulated these findings demonstrate that overexpression of hsa_circ_0022742 suppressed HG-induced endothelial dysfunction by targeting the miR-503-5p/FBXW7 axis. 1 Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway. - hsa_circ_ZFPM2 circZFPM2 DOID:288 endometriosis of uterus endometriosis "RT-qPCR, RNA-seq" up-regulated Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway. 1 Circular RNA SMEK1 promotes neuropathic pain in rats through targeting microRNA-216a-5p to mediate Thioredoxin Interacting Protein (TXNIP) expression. - rno_circ_SMEK1 circSMEK1 DOID:936 brain disease neuropathic pain RT-qPCR up-regulated circSMEK1 facilitates NP inflammation and microglia M1 polarization by modulating miR-216a-5p/TXNIP axis. 1 Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer. hsa_circ_0000677 - circ_0000677 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer. 1 Circular RNA PUM1 (CircPUM1) attenuates trophoblast cell dysfunction and inflammation in recurrent spontaneous abortion via the MicroRNA-30a-5p (miR-30a-5p)/JUNB axis. - hsa_circ_PUM1 circPUM1 DOID:229 female reproductive system disease Recurrent spontaneous abortion RT-qPCR down-regulated "circPUM1 could impair RSA occurrence and development by facilitating trophoblast cellular processes and protecting against inflammation via the miR-30a-5p/JUNB axis, providing a new target for the improvement of RSA diagnosis and treatment." 1 Downregulation of circ_0000673 Promotes Cell Proliferation and Migration in Endometriosis via the Mir-616-3p/PTEN Axis. hsa_circ_0000673 - circ_0000673 DOID:288 endometriosis of uterus endometriosis RT-qPCR down-regulated circ_0000673 could promote the progression of endometriosis by inactivating PTEN via the deregulation of miR-616-3p. 1 "Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the miR_331_3p/TGF_betaR1 axis in pre_eclampsia." hsa_circ_0026552 hsa_circ_IGFBP6 - DOID:10591 pre-eclampsia preeclampsia "RT-qPCR, microarray" up-regulated "Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the miR_331_3p/TGF_betaR1 axis in pre_eclampsia." 1 Plasma circular RNA hsa_circ_0001821 acts as a novel diagnostic biomarker for malignant tumors. hsa_circ_0001821 hsa_circ_TCONS_00015354 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "lasma hsa_circ_0001821 was increased in CRC patients, and high hsa_circ_0001821 expression predicted advanced stage and unfavorable in overall survival." 3 circHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma. hsa_circ_0008621 - circHMGCS1-016 DOID:4928 intrahepatic cholangiocarcinoma intrahepatic cholangiocarcinoma "RT-qPCR, RNA-seq" up-regulated circHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma. 1 "Circular RNA La-related protein 4 inhibits cell proliferation, migration, and invasion and sponges microRNA-367 in non-small cell lung cancer." - hsa_circ_LARP4 circRNA LARP4 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "circRNA LARP4 is downregulated, suppresses cell proliferation, migration, and invasion, and acts as a sponge of oncogene miR-367 in NSCLC." 4 CircLPAR3 Acts as an Oncogene in Oral Squamous Cell Carcinoma Through Regulating the miR-643/HMGB2 Network. - hsa_circ_LPAR3 CircLPAR3 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated CircLPAR3 Acts as an Oncogene in Oral Squamous Cell Carcinoma Through Regulating the miR-643/HMGB2 Network. 3 Hsa_circ_0001021 regulates intestinal epithelial barrier function via sponging miR-224-5p in ulcerative colitis. hsa_circ_0001021 hsa_circ_AFTPH circ_0001021 DOID:8577 ulcerative colitis ulcerative colitis "RT-qPCR, microarray" down-regulated hsa_circ_0001021 was significantly downregulated in patients with UC and was related to Mayo scores. 1 Circ_0000514 promotes breast cancer progression by regulating the miR-296-5p/CXCL10 axis. hsa_circ_0000514 - Circ_0000514 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated Circ_0000514 promotes breast cancer progression by regulating the miR-296-5p/CXCL10 axis. 1 Hsa_Circ_0001947/MiR-661/DOK7 Axis Restrains Non-Small Cell Lung Cancer Development. hsa_circ_0001947 hsa_circ_AFF2 Circ_0001947 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated Hsa_circ_0001947 acts as a sponge of miR-661 to repress NSCLC development by elevating the expression of DOK7. 1 Circ-SFMBT2 drives the malignant phenotypes of esophageal cancer by the miR-107-dependent regulation of SLC1A5. - hsa_circ_SFMBT2 Circ-SFMBT2 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated circ-SFMBT2 upregulated the SLC1A5 expression to promote the malignant development of EC by serving as a miR-107 sponge. 1 CircPTCH1 Promotes Migration in Lung Cancer by Regulating MYCN Expression Through miR-34c-5p. - hsa_circ_PTCH1 CircPTCH1 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated "circPTCH1 plays a tumor enhancement role in lung cancer and that can effectively promote migration, invasion and EMT by targeting the miR-34c-5p/MYCN axis." 1 Candidate oncogene circularNOP10 mediates gastric cancer progression by regulating miR-204/SIRT1 pathway. - hsa_circ_NOP10 circNOP10 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Candidate oncogene circNOP10 mediated GC cell proliferation, arrest cell cycle in G(2)/M phase, induced cell apoptosis, enhanced tumor metastasis, as well as EMT by activating the miR-204/SIRT1 pathway, suggesting that it may serve as a potential biomarker in GC therapy." 1 CircRNA hsa_circ_0006220 acts as a tumor suppressor gene by regulating miR-197-5p/CDH19 in triple-negative breast cancer. hsa_circ_0006220 hsa_circ_TADA2A - DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR down-regulated CircRNA hsa_circ_0006220 acts as a tumor suppressor gene by regulating miR-197-5p/CDH19 in triple-negative breast cancer. 1 hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma. hsa_circ_0000006 hsa_circ_SLC35E2B circ_0000006 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" down-regulated hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma. 2 Circular RNA _0015278 inhibits the progression of non-small cell lung cancer through regulating the microRNA 1278/SOCS6 gene axis. hsa_circ_0015278 - Circ_0015278 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "circ_0015278 attenuated the progression of NSCLC via targeting the miR-1278/SOCS6 axis, which provides potential diagnostic biomarkers and therapeutic targets." 1 CircMMP1 promotes colorectal cancer growth and metastasis by sponging miR-1238 and upregulating MMP family expression. hsa_circ_0024109 hsa_circ_MMP1 CircMMP1 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated CircMMP1 promotes colorectal cancer growth and metastasis by sponging miR-1238 and upregulating MMP family expression. 1 Involvement of ferroptosis in the granulosa cells proliferation of PCOS through the circRHBG/miR-515/SLC7A11 axis. - hsa_circ_RHBG circRHBG DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, microarray" up-regulated circRHBG inhibits ferroptosis in PCOS cells through the circRHBG/miR-515-5p/SLC7A11 axis in PCOS. 1 Circ_NCKAP1 promotes skin basal cell carcinoma progression by sponging the miR-148b-5p/HSP90 axis. - hsa_circ_NCKAP1 Circ_NCKAP1 DOID:2513 basal cell carcinoma skin basal cell carcinoma "RT-qPCR, microarray" up-regulated "Circ_NCKAP1 can promote skin BCC progression by sponging the miR-148b-5p/HSP90 axis, and circ_NCKAP1 may be a potential target for skin BCC therapy." 1 Circular RNA-0007059 protects cell viability and reduces inflammation in a nephritis cell model by inhibiting microRNA-1278/SHP-1/STAT3 signaling. hsa_circ_0007059 - circ_0007059 DOID:10952 nephritis nephritis "RT-qPCR, microarray" down-regulated circ_0007059 protects RMCs against apoptosis and inflammation during nephritis by attenuating miR-1278/SHP-1/STAT3 signaling. 1 "Circ_0007534 Silencing Inhibits the Proliferation, Migration and Invasion and Induces the Apoptosis of Glioma Cells Partly Through Down-Regulating PROX1 Via Elevating miR-22-3p Level." hsa_circ_0007534 - Circ_0007534 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Circ_0007534 aggravated glioma progression through elevating PROX1 expression via targeting miR-22-3p, which provided new targets for the diagnosis and treatment of glioma." 2 Exosome-mediated circ_0001846 participates in IL-1beta-induced chondrocyte cell damage by miR-149-5p-dependent regulation of WNT5B. hsa_circ_0001846 - circ_0001846 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Exosome-mediated transfer of circ_0001846 modulated IL-1beta-induced chondrocyte cell damage by miR-149-5p/WNT5B axis, providing a novel avenue for the therapy of OA." 1 Identification of Circular RNAs Circ_0005008 and Circ_0005198 in Plasma as Novel Biomarkers for New-Onset Rheumatoid Arthritis. hsa_circ_0005008 - circ_0005008 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" up-regulated "Circ_0005008 and circ_0005198 were confirmed to be elevated significantly in plasma samples from new-onset patients with RA compared with those from HCs and from patients with systemic lupus erythematosus. Among these new-onset patients with RA, we found that the levels of circ_0005008 and circ_0005198 correlated positively with the severity of disease, including the rheumatoid factor, C-reactive protein, the erythrocyte sedimentation rate, and the disease activity score in 28 joints (DAS28). " 1 Identification of Circular RNAs Circ_0005008 and Circ_0005198 in Plasma as Novel Biomarkers for New-Onset Rheumatoid Arthritis. hsa_circ_0005198 - Circ_0005198 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, microarray" up-regulated "Circ_0005008 and circ_0005198 were confirmed to be elevated significantly in plasma samples from new-onset patients with RA compared with those from HCs and from patients with systemic lupus erythematosus. Among these new-onset patients with RA, we found that the levels of circ_0005008 and circ_0005198 correlated positively with the severity of disease, including the rheumatoid factor, C-reactive protein, the erythrocyte sedimentation rate, and the disease activity score in 28 joints (DAS28). " 1 circRNA circ_POLA2 increases microRNA-31 methylation to promote endometrial cancer cell proliferation. - hsa_circ_POLA2 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated circ_POLA2 may increase miR-31 methylation of miR-31 in EC cells to promote cancer cell proliferation. 1 circNFIX facilitates hepatocellular carcinoma progression by targeting miR-3064-5p/HMGA2 to enhance glutaminolysis. - hsa_circ_NFIX circNFIX DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circNFIX serves as a competing endogenous RNA to accelerate HCC progression via regulating miR-3064-5p/HMGA2 axis, suggesting a therapeutic strategy for HCC intervention." 1 CircUBXN7 mitigates H/R-induced cell apoptosis and inflammatory response through the miR-622-MCL1 axis. - hsa_circ_UBXN7 circUBXN7 DOID:5844 myocardial infarction acute myocardial infarction RT-qPCR down-regulated CircUBXN7 mitigates cardiomyocyte apoptosis and inflammatory reaction in H/R injury by targeting miR-622 and maintaining MCL1 expression. Our study provides novel potential therapeutic targets for AMI treatment. 2 CircGLIS3 Promotes High-Grade Glioma Invasion via Modulating Ezrin Phosphorylation. hsa_circ_0002874 hsa_circ_GLIS3 CircGLIS3 DOID:0060108 brain glioma high-grade glioma "RT-qPCR, microarray" up-regulated circGLIS3 is upregulated in high-grade glioma and contributes to the invasion and angiogenesis of glioma via modulating Ezrin T567 phosphorylation. 2 "Silencing circ_BIRC6 inhibits the proliferation, invasion, migration and epithelial_mesenchymal transition of bladder cancer cells by targeting the miR_495_3p/XBP1 signaling axis." - hsa_circ_BIRC6 circ_BIRC6 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Silencing circ_BIRC6 inhibits the proliferation, invasion, migration and epithelial_mesenchymal transition of bladder cancer cells by targeting the miR_495_3p/XBP1 signaling axis." 1 "Circular RNA MTO1 intercorrelates with microRNA-630, both associate with Enneking stage and/or pathological fracture as well as prognosis in osteosarcoma patients." - hsa_circ_MTO1 circ-MTO1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "Circular RNA MTO1 intercorrelates with microRNA-630, both associate with Enneking stage and/or pathological fracture as well as prognosis in osteosarcoma patients." 2 Serum Circ-FAF1/Circ-ELP3: A novel potential biomarker for breast cancer diagnosis. - hsa_circ_ELP3 Circ-ELP3 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ-ELP3 was upregulated in breast cancer patients (p-value = 0.004). On the other hand, serum Circ-FAF1 was seen to be decreased in breast cancer patients than controls (p-value = 0.001). " 3 Serum Circ-FAF1/Circ-ELP3: A novel potential biomarker for breast cancer diagnosis. - hsa_circ_FAF1 Circ-FAF1 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "Circ-ELP3 was upregulated in breast cancer patients (p-value = 0.004). On the other hand, serum Circ-FAF1 was seen to be decreased in breast cancer patients than controls (p-value = 0.001). " 2 CircSAMD11 facilitates progression of cervical cancer via regulating miR-503/SOX4 axis through Wnt/beta-catenin pathway. - hsa_circ_SAMD11 CircSAMD11 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "CircSAMD11 contributed to CC progression by regulating miR-503/SOX4 signalling and activating Wnt/beta-catenin pathway, which provides a promising therapeutic target for cervical cancer." 1 Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway. - hsa_circ_PIP5K1A circPIP5K1A DOID:288 endometriosis of uterus endometriosis RT-qPCR up-regulated "circPIP5K1A accelerated EM progression in vitro by activating the TGF-beta signaling pathway via the miR-153-3p/TMSB4X axis, providing a potential clinical target for EM treatment." 1 Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/XIAP axis. - hsa_circ_RANBP9 circ_RANBP9 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RT-qPCR up-regulated Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/XIAP axis. 2 Circular RNA Cdyl promotes abdominal aortic aneurysm formation by inducing M1 macrophage polarization and M1-type inflammation. - mmu_circ_Cdyl circCdyl DOID:3627 aortic aneurysm abdominal aortic aneurysm RT-qPCR up-regulated Our results indicate an important role for circCdyl-mediated macrophage polarization in AAA formation and provide a potent therapeutic target for AAA treatment. 1 Identification of the tumor_suppressive role of circular RNA_FOXO3 in colorectal cancer via regulation of miR_543/LATS1 axis. hsa_circ_0006404 hsa_circ_FOXO3 circ_FOXO3 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "circ_FOXO3 inhibited CRC metastasis and progression via elevated LATS1 expression by sponging miR_543. Therefore, circ_FOXO3 may be a promising target for CRC therapy." 1 Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer. - hsa_circ_WHSC1 circ-WHSC1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer. 3 Circular RNA circDNA2 upregulates CCDC6 expression to promote the progression of gastric cancer via miR-149-5p suppression. - hsa_circ_DNA2 circDNA2 DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq, microarray" up-regulated circDNA2 contributes to the growth and lymphatic metastasis of GC by upregulating CCDC6 expression by sponging miR-149-5p. 2 Circular RNA SERPINE2 promotes development of glioblastoma by regulating the miR-361-3p/miR-324-5p/BCL2 signaling pathway. - hsa_circ_SERPINE2 circSERPINE2 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, microarray" up-regulated Circular RNA SERPINE2 promotes development of glioblastoma by regulating the miR-361-3p/miR-324-5p/BCL2 signaling pathway. 1 Knockdown of circ_0004104 Alleviates Oxidized Low-Density Lipoprotein-Induced Vascular Endothelial Cell Injury by Regulating miR-100/TNFAIP8 Axis. hsa_circ_0004104 - circ_0004104 DOID:3393 coronary artery disease Coronary artery disease RT-qPCR down-regulated "Our data suggested that circ_0004104 promoted ox-LDL-induced VEC injury by the miR-100/TNFAIP8 axis, indicating that circ_0004104 might be a potential biomarker for CAD treatment." 2 CircRNA circ_0001821 predicts an unfavorable prognosis and promotes the proliferation of multiple myeloma. hsa_circ_0001821 - circ_0001821 DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated High expression of circ_0001821 associated with aggressive pathological indicators and predicted a poor prognosis in multiple myeloma. Circ_0001821 played an oncogenic role in multiple myeloma by modulating cell proliferation and apoptosis. 1 "Circ_0001490/miR-579-3p/FSTL1 axis modulates the survival of mycobacteria and the viability, apoptosis and inflammatory response in Mycobacterium tuberculosis-infected macrophages." hsa_circ_0001490 - circ_0001490 DOID:399 tuberculosis tuberculosis RT-qPCR down-regulated "In conclusion, our results demonstrated that circ_0001490 suppressed M.tb survival and promoted the viability and inflammatory response of M.tb-infected THP-1 macrophages partly by regulating miR-579-3p/FSTL1 axis." 1 Hsa_circ_0088212-mediated miR-520 h/APOA1 axis inhibits osteosarcoma progression. hsa_circ_0088212 hsa_circ_PAPPA - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated circ_0088212 might exert a tumor-suppressive activity in osteosarcoma by sponging and sequestering miR-520 h away from APOA1. 5 "CircHAS2 promotes the proliferation, migration, and invasion of gastric cancer cells by regulating PPM1E mediated by hsa-miR-944." - hsa_circ_HAS2 CircHAS2 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "CircHAS2 promotes the proliferation, migration, and invasion of gastric cancer cells by regulating PPM1E mediated by hsa-miR-944." 1 Circular RNA hsa_circ_0001598 promotes programmed death-ligand-1-mediated immune escape and trastuzumab resistance via sponging miR-1184 in breast cancer cells. hsa_circ_0001598 hsa_circ_DEF6 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circ_0001598/miR-1184/PD-L1 signaling plays a crucial role in the regulation of BC progression and trastuzumab-resistance phonotypes, which suggests that circ_0001598 may be a molecular target to treat HER2-positive BC patients." 1 Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain. - hsa_circ_Tshz2-2 circTshz2-2 DOID:9970 obesity obesity RT-qPCR up-regulated Our data have revealed potential regulatory roles of obesity-related circTshz2-2 on the neuronal cell cycle and memory function providing a novel link between metabolic syndromes and cognitive deficits. 1 "Circular RNA hsa_circ_0000730 restrains cell proliferation, migration, and invasion in cervical cancer through miR-942-5p/PTEN axis." hsa_circ_0000730 hsa_circ_PITPNA - DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated "Circ_0000730 inhibits the proliferation, migration, and invasion of CC cells via regulating miR-942-5p/PTEN axis." 1 "Circ_0011058 facilitates proliferation, angiogenesis and radioresistance in papillary thyroid cancer cells by positively regulating YAP1 via acting as miR-335-5p sponge." hsa_circ_0011058 - Circ_0011058 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "Circ_0011058 promoted PTC cell proliferation, angiogenesis and radioresistance by upregulating YAP1 via acting as miR-335-5p sponge." 1 circMBOAT2 serves as the sponge of miR-433-3p to promote the progression of bladder cancer. - hsa_circ_MBOAT2 circMBOAT2 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated circMBOAT2 serves as the sponge of miR-433-3p to promote the progression of bladder cancer. 1 CircRNA Circ-CCND1 Aggravates Hepatocellular Carcinoma Tumorigenesis by Regulating the miR-497-5p/HMGA2 Axis. - hsa_circ_CCND1 circ-CCND1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ-CCND1 plays a cancer-promoting role in HCC by modulating the miR-497-5p/HMGA2 axis. 1 Circ_0006948 drives the malignant development of bladder cancer via activating the epithelial-mesenchymal transition. hsa_circ_0006948 - Circ_0006948 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Circ_0006948 is upregulated in BC samples, and it is closely linked to tumor stage, metastasis and prognosis in BC patients. It drives proliferative and metastatic abilities in BC cells by activating EMT." 1 A potential diagnostic marker for osteosarcoma: hsa_circ_0005721. hsa_circ_0005721 hsa_circ_TEP1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "hsa_circ_0005721 is upregulated in osteosarcoma samples, which acts as an oncogene responsible for aggravating the progression." 2 "hsa_circ_0005721 triggers proliferation, migration and invasion of osteosarcoma by upregulating the linear transcript TEP1." hsa_circ_0005721 hsa_circ_TEP1 circ_0005721 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "hsa_circ_0005721 triggers proliferation, migration and invasion of osteosarcoma by upregulating the linear transcript TEP1." 2 Circular RNA hsa_circ_0000751 serves as a microRNA-488 sponge to suppress gastric cancer progression via ubiquinol-cytochrome c reductase core protein 2 regulation. hsa_circ_0000751 hsa_circ_NUFIP2 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Circular RNA hsa_circ_0000751 serves as a microRNA-488 sponge to suppress gastric cancer progression via ubiquinol-cytochrome c reductase core protein 2 regulation. 1 Circ_0079558 promotes papillary thyroid cancer progression by binding to miR-26b-5p to activate MET/AKT signaling. hsa_circ_0079558 - Circ_0079558 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated circ_0079558 facilitated the proliferation and motility whereas inhibited the apoptosis of PTC cells largely through mediating miR-26b-5p/MET/AKT signaling. 1 Circular RNA hsa_circ_0000073 Enhances Osteosarcoma Cells Malignant Behavior by Sponging miR-1252-5p and Modulating CCNE2 and MDM2. hsa_circ_0000073 hsa_circ_OMA1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "hsa_circ_0000073 functions as a tumor promoter in OS to increase malignant tumor behavior through sponging miR-1252-5p and regulating CCNE2 and MDM2 expression, which could be a novel target for OS therapy." 4 Tumor Cell-Derived Exosomal Circ-0072088 Suppresses Migration and Invasion of Hepatic Carcinoma Cells Through Regulating MMP-16. hsa_circ_0072088 - Circ-0072088 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated Tumor Cell-Derived Exosomal Circ-0072088 Suppresses Migration and Invasion of Hepatic Carcinoma Cells. 2 Circ_0004018 suppresses cell proliferation and migration in hepatocellular carcinoma via miR-1197/PTEN/PI3K/AKT signaling pathway. hsa_circ_0004018 - Circ_0004018 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated circ_0004018 suppresses the proliferation and migration of HCC cells via sponging miR-1197 to inactivate the PTEN/PI3K/AKT signaling pathway. 3 Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis. hsa_circ_0033009 hsa_circ_LGMN circLGMN DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" up-regulated Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis. 1 "circ-ACACA promotes proliferation, invasion, migration and glycolysis of cervical cancer cells by targeting the miR-582-5p/ERO1A signaling axis." - hsa_circ_ACACA circ-ACACA DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circ-ACACA may promote CC tumorigenesis and glycolysis by targeting the miR-582-5p/ERO1A signaling axis. 1 CircIMMP2L promotes esophageal squamous cell carcinoma malignant progression via CtBP1 nuclear retention dependent epigenetic modification. - hsa_circ_IMMP2L CircIMMP2L DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "circIMMP2L promotes the malignant progression of ESCC mediated by CtBP1 nuclear retention and is a robust biomarker for the diagnosis, prognosis, and LNM in ESCC." 1 Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis. hsa_circ_0043280 hsa_circ_TADA2A - DOID:4362 cervical cancer cervical cancer "RT-qPCR, microarray" down-regulated Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis. 1 CircRNA Microarray Profiling Reveals hsa_circ_0058493 as a Novel Biomarker for Imatinib-Resistant CML. hsa_circ_0058493 hsa_circ_RHBDD1 - DOID:8552 chronic myeloid leukemia chronic myeloid leukemia "RT-qPCR, microarray" up-regulated Hsa_circ_0058493 was significantly overexpressed in the PBMCs of CML patients and high level of circ_0058493 was associated with the poor clinical efficacy of imatinib. 1 Circular RNA circNF1 siRNA Silencing Inhibits Glioblastoma Cell Proliferation by Promoting the Maturation of miR-340. - hsa_circ_NF1 circNF1 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated Circular RNA circNF1 siRNA Silencing Inhibits Glioblastoma Cell Proliferation by Promoting the Maturation of miR-340. 2 Hepatocellular carcinoma progression mediated by hepatitis B virus-encoded circRNA HBV_circ_1 through interaction with CDK1. - hsa_circ_HBV_1 circRNA HBV_circ_1 DOID:684 hepatocellular carcinoma HBV-related hepatocellular carcinoma "RT-qPCR, RNA-seq, microarray" up-regulated HCC progression may be promoted by interaction of HBV_circ_1 with CDK1. 1 circUSP34 accelerates osteosarcoma malignant progression by sponging miR-16-5p. - hsa_circ_USP34 circUSP34 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circUSP34 promoted OS malignancy, including proliferation, migration, and invasion, by sponging miR-16-5p." 1 The expression profile and clinical application value of hsa_circ_0016148 in head and neck squamous cell carcinoma. hsa_circ_0016148 hsa_circ_PIK3C2B - DOID:5520 head and neck squamous cell carcinoma head and neck squamous cell carcinoma "RT-qPCR, microarray" down-regulated Our study showed a circRNA expression profile and confirmed downregulated hsa_circ_0016148 in HNSCC tissues. 1 Circ-RPPH1 knockdown retards breast cancer progression via miR-328-3p-mediated suppression of HMGA2. - hsa_circ_RPPH1 Circ-RPPH1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ-RPPH1 knockdown retarded cell malignant phenotypes and glycolysis via miR-328-3p/HMGA2 axis in BC, providing a potential therapeutic target for BC treatment." 9 "circRNA_PTPRA functions as a sponge of miR-582-3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis." - hsa_circ_PTPRA circRNA_PTPRA DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circRNA_PTPRA functions as a sponge of miR-582-3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis." 1 Circular RNA hsa_circ_0007507 May Serve as a Biomarker for the Diagnosis and Prognosis of Gastric Cancer. hsa_circ_0007507 hsa_circ_RASA1 - DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated the expression of hsa_circ_0007507 was significantly higher than that of normal people. 1 Circular RNA CircPPP1CB Suppresses Tumorigenesis by Interacting With the MiR-1307-3p/SMG1 Axis in Human Bladder Cancer. - hsa_circ_PPP1CB CircPPP1CB DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "circPPP1CB participates in tumor growth, metastasis, and EMT process by interacting with the miR-1307-3p/SMG1 axis, and that circPPP1CB might be a novel therapeutic target and diagnostic biomarker in human BC." 1 The profile analysis of circular RNAs in cervical cancer. hsa_circ_0000745 hsa_circ_SPECC1 - DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0000745, hsa_circ_0084927, hsa_circ_0002762, hsa_circ_0007905 were upregulated and hsa_circ_0078383 was downregulated in CC tissues (P < .001)." 2 The profile analysis of circular RNAs in cervical cancer. hsa_circ_0084927 hsa_circ_ESRP1 - DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0000745, hsa_circ_0084927, hsa_circ_0002762, hsa_circ_0007905 were upregulated and hsa_circ_0078383 was downregulated in CC tissues (P < .001)." 3 The profile analysis of circular RNAs in cervical cancer. hsa_circ_0002762 hsa_circ_CDK17 - DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0000745, hsa_circ_0084927, hsa_circ_0002762, hsa_circ_0007905 were upregulated and hsa_circ_0078383 was downregulated in CC tissues (P < .001)." 4 The profile analysis of circular RNAs in cervical cancer. hsa_circ_0007905 hsa_circ_STX6 - DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0000745, hsa_circ_0084927, hsa_circ_0002762, hsa_circ_0007905 were upregulated and hsa_circ_0078383 was downregulated in CC tissues (P < .001)." 1 The profile analysis of circular RNAs in cervical cancer. hsa_circ_0078383 - - DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" down-regulated "hsa_circ_0000745, hsa_circ_0084927, hsa_circ_0002762, hsa_circ_0007905 were upregulated and hsa_circ_0078383 was downregulated in CC tissues (P < .001)." 1 Hsa_circ_0011385 knockdown represses cell proliferation in hepatocellular carcinoma. hsa_circ_0011385 hsa_circ_EIF3I - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "High expression of circ_0011385 was observed in HCC tissues and cell lines and was significantly associated with tumor size, TNM stage, and prognosis. In addition, inhibition of circ_0011385 expression prevented the proliferation of HCC cells in vitro and in vivo. Circ_0011385 sponged miR-361-3p, thereby regulating the mRNA expression of STC2." 2 CircPTK2 Suppresses the Progression of Gastric Cancer by Targeting the MiR-196a-3p/AATK Axis. hsa_circ_0005273 hsa_circ_PTK2 CircPTK2 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "circPTK2 functions as a tumor suppressor to suppress gastric cancer cell proliferation, migration, and invasion through regulating the miR-196a-3p/AATK axis, suggesting that circPTK2 may serve as a novel therapeutic target for gastric cancer." 1 Circular RNA 0006349 Augments Glycolysis and Malignance of Non-small Cell Lung Cancer Cells Through the microRNA-98/MKP1 Axis. hsa_circ_0006349 - Circ_0006349 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "This research demonstrated that circ_0006349 derepressed MKP1 expression by absorbing miR-98, which augmented the proliferation and glycolysis of NSCLC cells and promoted cancer development." 1 Circular RNA circPRKDC promotes tumorigenesis of gastric cancer via modulating insulin receptor substrate 2 (IRS2) and mediating microRNA-493-5p. - hsa_circ_PRKDC circPRKDC DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circPRKDC accelerated GC development via sponging miR-493-5p and increasing IRS2. 1 Circ_0078710 promotes the development of liver cancer by upregulating TXNDC5 via miR-431-5p. hsa_circ_0078710 - Circ_0078710 DOID:3571 liver cancer liver cancer RT-qPCR up-regulated Circ_0078710 promotes the progression of liver cancer by regulating TXNDC5 expression by targeting miR-431-5p. 1 Downregulation of circular RNA circ-HN1 suppressed the progression of gastric cancer through the miR-485-5p/GSK3A pathway. - hsa_circ_HN1 circ-HN1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "silencing of the circ-HN1-miR-485-5p-GSK3A regulatory network inhibited GC cell proliferation, migration, and invasion, suggesting that circ-HN1 is a potential target for GC therapy." 4 Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis. - hsa_circ_UBE2Q2 circUBE2Q2 DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis. 1 Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR-214. - hsa_circ_ITCH circ-ITCH DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR down-regulated "circ-ITCH suppressed NPC tumorigenesis by upregulating PTEN expression through interacting with miR-214, thus proposing a novel mechanism for NPC inhibition." 1 Circular RNA ERBB2 Contributes to Proliferation and Migration of Airway Smooth Muscle Cells via miR-98-5p/IGF1R Signaling in Asthma. - hsa_circ_ERBB2 circERBB2 DOID:2841 asthma Asthma RT-qPCR up-regulated "Our work disclosed that knockdown of circERBB2 suppressed PDGF-BB-caused proliferation, migration and inflammatory response of ASMCs, through regulating miR-98-5p/IGF1R signaling, presented circERBB2 as a promising therapeutic target for asthma." 1 Circular RNA circCRKL inhibits the proliferation of acute myeloid leukemia cells via the miR-196a-5p/miR-196b-5p/p27 axis. - hsa_circ_CRKL circCRKL DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR down-regulated "circCRKL inhibited AML cell proliferation via the miR-196a-5p/miR-196b-5p/p27 axis, suggesting a potential new target for AML therapy." 1 The effects of hsa_circ_0000517/miR-326 axis on the progression of breast cancer cells and the prediction of miR-326 downstream targets in breast cancer. hsa_circ_0000517 hsa_circ_RPPH1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated hsa_circ_0000517 silencing repressed breast cancer progression by upregulating miR-326 expression. 9 "Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to regulate proliferation, migration, invasion and apoptosis of oral squamous cell carcinoma cells." hsa_circ_0011946 - circ_0011946 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Circ_0011946 silence repressed OSCC cell proliferation, migration, and invasion, but promoted apoptosis through the regulation of the miR-216a-5p/BCL2L2 axis." 3 Exosomal circ_0007385 enhances non-small cell lung cancer cell proliferation and stemness via regulating miR-1253/FAM83A axis. hsa_circ_0007385 - circ_0007385 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Exosomal circ_0007385 promoted NSCLC cell proliferation and stemness by regulating miR-1253/FAM83A axis. 5 The expression of circ_0090049 in hepatocellular carcinoma and the molecular regulation mechanism of other biological functions. hsa_circ_0090049 - circ_0090049 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0090049 regulates the expression of UBE2T by regulating miR-605-5p or miR-548c-3p, thereby promoting the development of HCC cells." 2 CircDTL Functions as an Oncogene and Regulates Both Apoptosis and Ferroptosis in Non-small Cell Lung Cancer Cells. - hsa_circ_DTL CircDTL DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircDTL acts as an oncogene and exerts its effects via the miR-1287-5p/GPX4 axis in NSCLC. 1 CircWHSC1 regulates malignancy and glycolysis by the miR-212-5p/AKT3 pathway in triple-negative breast cancer. - hsa_circ_WHSC1 CircWHSC1 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated CircWHSC1 accelerated malignancy and glycolysis of TNBC cells by the miR-212-5p/AKT3 axis. 1 CircCDC45 promotes the malignant progression of glioblastoma by modulating the miR-485-5p/CSF-1 axis. - hsa_circ_CDC45 CircCDC45 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "CircCDC45 promoted the progression of GBM by mediating the miR-485-5p/CSF-1 axis, and circCDC45 might be a promising plasmatic biomarker for GBM diagnosis and treatment." 1 CircRNA_0084927 promotes colorectal cancer progression by regulating miRNA-20b-3p/glutathione S-transferase mu 5 axis. hsa_circ_0084927 - circ_0084927 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated CircRNA_0084927 promotes colorectal cancer progression by regulating miRNA-20b-3p/glutathione S-transferase mu 5 axis. 2 Circular RNA ATAD1 is upregulated in acute myeloid leukemia and promotes cancer cell proliferation by downregulating miR-34b via promoter methylation. - hsa_circ_ATAD1 circ-ATAD1 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "circ-ATAD1 as a nucleus-specific circRNA in AML, which promotes AML cell proliferation by downregulating miR-34b via methylation." 1 circ_0023461 Silencing Protects Cardiomyocytes from Hypoxia-Induced Dysfunction through Targeting miR-370-3p/PDE4D Signaling. hsa_circ_0023461 - circ_0023461 DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR up-regulated circ_0023461 Silencing Protects Cardiomyocytes from Hypoxia-Induced Dysfunction through Targeting miR-370-3p/PDE4D Signaling. 1 LRRC4 mediates the formation of circular RNA CD44 to inhibitGBM cell proliferation. - hsa_circ_CD44 circCD44 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated downregulated expression of circCD44 was found in glioblastoma multiforme (GBM) tissues and GBM primary cells. 1 circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression. hsa_circ_0044556 hsa_circ_COL1A1 circCOL1A1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression. 3 Circ_0075804 promotes the malignant behaviors of retinoblastoma cells by binding to miR-138-5p to induce PEG10 expression. hsa_circ_0075804 - Circ_0075804 DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated Circ_0075804 promoted RB progression via miR-138-5p-dependent regulation of PEG10. 3 CircRNA CircZMYM4 inhibits the growth and metastasis of lung adenocarcinoma via the miR-587/ODAM pathway. - hsa_circ_ZMYM4 CircZMYM4 DOID:3910 lung adenocarcinoma lung adenocarcinoma "RT-qPCR, RNA-seq, microarray" down-regulated "circZMYM4 upregulated ODAM expression via sponging miR-587 to suppress LUAD progression. ODAM knockdown could reverse the repressive effect of circZMYM4 overexpression on cell proliferation, migration and invasion abilities." 1 Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA. - hsa_circ_ATRNL1 circATRNL1 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated circATRNL1 promoted osteosarcoma progression by enhancing glycolysis via circATRNL1/miR-409-3p/LDHA axis. 1 Identification of circRNA_001846 as putative non-small cell lung cancer biomarker. - - circRNA_001846 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated "serum samples from NSCLC patients exhibited circRNA_001846 upregulation relative to those from healthy individuals. The circRNA_001846 was associated with tumor differentiation, lymph node metastasis, and node metastasis stage." 1 Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-beta2/SMAD3 pathway. - hsa_circ_COG2 circCOG2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Upregulated circCOG2 promoted CRC proliferation, migration, and invasion through the miR-1305/TGF-beta2/SMAD3 pathway, and this effect could be transmitted from CRC cells with the high metastatic potential to CRC cells with low metastatic potential by exosomes." 1 Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma. - hsa_circ_FOXP1 circFOXP1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circFOXP1 promoted angiogenesis by regulating miR-127-5p/CDKN2AIP signaling pathway in osteosarcoma. 1 A novel circular RNA circ_HN1/miR-628-5p/Ecto-5-nucleotidase competing endogenous RNA network regulates gastric cancer development. - hsa_circ_HN1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circ_HN1 expression was enhanced in human gastric cancer. Depletion of circ_HN1 impeded cell proliferation, spheroid formation, invasion, and migration and promoted apoptosis in vitro, as well as diminished tumor growth in vivo. NT5E was a downstream effector of circ_HN1 function." 4 circRNA_0006470 promotes the proliferation and migration of gastric cancer cells by functioning as a sponge of miR-27b-3p. hsa_circ_0006470 hsa_circ_MFN2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circRNA_0006470 promotes the proliferation and migration of gastric cancer cells by functioning as a sponge of miR-27b-3p. 5 Circular RNA hsa_circ_0002483 promotes growth and invasion of lung adenocarcinoma by sponging miR-125a-3p. hsa_circ_0002483 hsa_circ_PTK2 - DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "circ_0002483 could act as a sponge of miR-125a-3p to upregulate CCL4-CCR5 axis, contributing to the tumorigenesis of LUAC, and represent a potential therapeutic target for LUAC." 1 CircularRNA_0119872 regulates the microRNA-582-3p/E2F transcription factor 3 pathway to promote the progression of malignant melanoma. hsa_circ_0119872 - circ_0119872 DOID:1909 melanoma melanoma RT-qPCR up-regulated circ_0119872 facilitated MM progression by adsorbing miR-582-3p and upregulating E2F3 expression. 1 Circ_0026416 downregulation blocks the development of colorectal cancer through depleting MYO6 expression by enriching miR-545-3p. hsa_circ_0026416 - Circ_0026416 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0026416 downregulation inhibits CRC development in vitro and in vivo. 2. Circ_0026416 regulates the expression of MYO6 by targeting miR-545-3p. 3. Circ_0026416 governs the miR-545-3p/MYO6 axis to regulate CRC progression. 1 circFAM160A2 Promotes Mitochondrial Stabilization and Apoptosis Reduction in Osteoarthritis Chondrocytes by Targeting miR-505-3p and SIRT3. - hsa_circ_FAM160A2 circFAM160A2 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, microarray" down-regulated "circFAM160A2 can promote mitochondrial stabilization and apoptosis reduction in OA chondrocytes by targeting miR-505-3p and SIRT3, which might be a potential therapeutic target for OA therapy." 1 circAMOTL1L Suppresses Renal Cell Carcinoma Growth by Modulating the miR-92a-2-5p/KLLN Pathway. - hsa_circ_AMOTL1L circAMOTL1L DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR down-regulated circAMOTL1L has an antioncogenic role in RCC growth by modulating the miR-92a-2-5p-KLLN pathway. 1 Circ_0045714/miR-331-3p interaction affects IL-1beta-evoked human articular chondrocyte injury through regulating PIK3R3 in a ceRNA regulatory cascade. hsa_circ_0045714 - Circ_0045714 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "Expression of circ_0045714 and phosphoinositide-3-kinase (PI3K) regulatory subunit 3 (PIK3R3) was declined, and microRNA (miR)-331-3p was promoted in knee articular cartilages and cells from OA patients, as well as interleukin (IL)-1beta-challenged human articular chondrocytes (HAC) cell line." 4 Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. - hsa_circ_IPO11 circIPO11 DOID:3571 liver cancer liver cancer "RT-qPCR, RNA-seq, microarray" up-regulated circIPO11 drives the self-renewal of liver CSCs and promotes the propagation of HCC via activating Hedgehog signaling pathway. Antisense oligonucleotides (ASOs) against circIPO11 combined with TOP1 inhibitor camptothecin (CPT) exert synergistic antitumor effect. 2 CircRNA_002178 as a ceRNA promotes the development of colorectal cancer by regulating miR-542-3p/CREB1. - - CircRNA_002178 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ_002178 promotes the invasion, proliferation, colony formation, and glycolysis of CRC cells by regulating the miR-542-3p/CREB1 axis, thus driving the development of CRC." 1 Circular RNA hsa_circ_0005567 overexpression promotes M2 type macrophage polarization through miR-492/SOCS2 axis to inhibit osteoarthritis progression. hsa_circ_0005567 hsa_circ_EPS15 - DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "hsa_circ_0005567 overexpression promoted M2 macrophage polarization through miR-492/SOCS2 axis to reduced chondrocyte apoptosis, which could inhibit osteoarthritis progression." 2 Circular RNA circ_0073181 contributes to tumorigenesis by regulating protein tyrosine phosphatase receptor type E via miR-548p in hepatocellular carcinoma. hsa_circ_0073181 - Circ_0073181 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0073181 silencing could inhibit HCC cell growth and metastasis partly by regulating the miR-548p/ PTPRE axis, providing a promising therapeutic target for the HCC treatment." 2 Circ_0016760 accelerates non-small-cell lung cancer progression through miR-646/AKT3 signaling in vivo and in vitro. hsa_circ_0016760 - Circ_0016760 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0016760 played an oncogenic role to promote the proliferation, migration, and invasion and restrained the apoptosis of NSCLC cells via miR-646/AKT3 signaling." 6 CircSETD3 (Hsa_circ_0000567) Suppresses Hepatoblastoma Pathogenesis via Targeting the miR-423-3p/Bcl-2-Interacting Mediator of Cell Death Axis. hsa_circ_0000567 hsa_circ_SETD3 CircSETD3 DOID:687 hepatoblastoma hepatoblastoma RT-qPCR down-regulated "circSETD3 sponged miR-423-3p to upregulate Bim, resulting in the inhibition of HB development." 1 Circular RNA hsa_circ_0001306 Functions as a Competing Endogenous RNA to Regulate FBXW7 Expression by Sponging miR-527 in Hepatocellular Carcinoma. hsa_circ_0001306 hsa_circ_RAD54L2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated "Hsa_circ_001306 is significantly downregulated in HCC, and the hsa_circ_0001306/miR-527/FBXW7 axis plays an important role in HCC progression." 1 Circular RNA Hsa_circRNA_101996 promotes the development of Gastric Cancer via Upregulating Matrix Metalloproteinases-2/Matrix Metalloproteinases-9 through MicroRNA-143/Ten-eleven translocation-2 Pathway. - - hsa_circRNA_101996 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "hsa_circRNA_101996 promotes GC development by upregulating MMP2/MMP9 through miR-143/TET2 pathway, which may provide a novel target for GC." 1 circ-SIRT1 Promotes Colorectal Cancer Proliferation and EMT by Recruiting and Binding to eIF4A3. - hsa_circ_SIRT1 circ-SIRT1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ-SIRT1 functions as an oncogene in CRC by promoting the proliferation, invasion, and EMT of CRC cells through the circ-SIRT1/EIF4A3/N-cadherin/vimentin pathway." 1 Circular RNA NEK6 contributes to the development of non-small-cell lung cancer by competitively binding with miR-382-5p to elevate BCAS2 expression at post-transcriptional level. - hsa_circ_NEK6 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circular RNA NEK6 contributes to the development of non-small-cell lung cancer by competitively binding with miR-382-5p to elevate BCAS2 expression at post-transcriptional level. 1 Hsa_circ_0001806 promotes glycolysis and cell progression in hepatocellular carcinoma through miR-125b/HK2. hsa_circ_0001806 hsa_circ_CSPP1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "The inhibition of hsa_circ_0001806 suppressed HCC cell proliferation, migration and glycolysis through mediating miR-125b/HK2 axis." 6 CircGSK3B promotes RORA expression and suppresses gastric cancer progression through the prevention of EZH2 trans-inhibition. - hsa_circ_GSK3B CircGSK3B DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated "CircGSK3B acts as a tumor suppressor, reducing EZH2 trans-inhibition and GC progression." 1 CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression. - hsa_circ_GFRA1 CircGFRA1 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression. 3 Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer. - hsa_circ_PFKP circPFKP DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" down-regulated Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer. 1 Circular RNA Circ-0003006 Promotes Hepatocellular Carcinoma Proliferation and Metastasis Through Sponging miR-542-3p and Regulating HIF-1A. hsa_circ_0003006 - circ-0003006 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ-0003006 was demonstrated to promote HCC progression in vitro and in vivo by sponging miR_542_3p to release the inhibition on HIF-1A. 1 Overexpression of circAtp9b in ulcerative colitis is induced by lipopolysaccharides and upregulates PTEN to promote the apoptosis of colonic epithelial cells. - hsa_circ_Atp9b circAtp9b DOID:8577 ulcerative colitis ulcerative colitis RT-qPCR up-regulated overexpression of circAtp9b in UC was induced by LPS and it positively upregulated PTEN to promote the apoptosis of HCnEpCs induced by LPS. 1 circCORO1C promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing the expression of PD-L1 through NF-kappaB pathway. hsa_circ_0006852 hsa_circ_CORO1C circCORO1C DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq, microarray" up-regulated "CircCORO1C upregulates c-Myc and COX-2 through NF-kappaB signaling pathway, leading to the upregulation of PD-L1, which jointly promotes the development of HCC, suggesting that circCORO1C is a promising biomarker and therapeutic target for HCC." 3 Circular RNA circUBE2J2 acts as the sponge of microRNA-370-5P to suppress hepatocellular carcinoma progression. - hsa_circ_UBE2J2 circUBE2J2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated Circular RNA circUBE2J2 acts as the sponge of microRNA-370-5P to suppress hepatocellular carcinoma progression. 1 Bioinformatics analysis reveals a stem cell-expressed circ-Serpine2-mediated miRNA-mRNA regulatory subnetwork in the malignant progression of glioma. - hsa_circ_Serpine2 circ-Serpine2 DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" up-regulated Circ-Serpine2 exacerbated the malignant progression of glioma mediated by the miR-124-3p/KIF20A nexus. 1 CircRNA NRIP1 promotes papillary thyroid carcinoma progression by sponging mir-195-5p and modulating the P38 MAPK and JAK/STAT pathways. - - CircRNA NRIP1 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "CircRNA NRIP1 promoted PTC progression by accelerating PTC cells proliferation, invasion and tumor growth, while impeding apoptosis by way of sponging miR-195-5p and regulating the P38 MAPK and JAK/STAT pathways." 1 CircPTK2 (hsa_circ_0003221) Contributes to Laryngeal Squamous Cell Carcinoma by the miR-1278/YAP1 Axis. hsa_circ_0003221 hsa_circ_PTK2 CircPTK2 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated circPTK2 facilitates LSCC progression through the miR-1278/YAP1 axis. 1 Circular RNA Circ-0002570 Accelerates Cancer Progression by Regulating VCAN via MiR-587 in Gastric Cancer. hsa_circ_0002570 - Circ-0002570 DOID:162 cancer cancer RT-qPCR up-regulated Circular RNA Circ-0002570 Accelerates Cancer Progression by Regulating VCAN via MiR-587 in Gastric Cancer. 1 Circ_0001658 regulates gefitinib resistance of non-small cell lung cancer through miR-409-3p/TWIST1 axis. hsa_circ_0001658 - Circ_0001658 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0001658 promotes the malignant phenotypes and the resistance to gefitinib of NSCLC cells by regulating the miR-409-3p/TWIST1 axis. 1 Circular RNA circPRKCI contributes to malignant progression of T-cell acute lymphoblastic leukemia by modulating miR-20a-5p/SOX4 axis. - hsa_circ_PRKCI circPRKCI DOID:5603 T-cell acute lymphoblastic leukemia T-cell acute lymphoblastic leukemia RT-qPCR up-regulated we concluded that circular RNA circPRKCI contributed to malignant progression of T-cell acute lymphoblastic leukemia by modulating miR-20a-5p/SOX4 axis. Targeting circPRKCI may serve as a promising therapeutic strategy of T-ALL. 1 Hsa_circ_0004296 inhibits metastasis of prostate cancer by interacting with EIF4A3 to prevent nuclear export of ETS1 mRNA. hsa_circ_0004296 hsa_circ_ETS1 - DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated "Circ_0004296 overexpression efficiently inhibited ETS1 mRNA nuclear export by promoting EIF4A3 retention in the nucleus, leading to the downregulation of ETS1 expression and suppression of PCa metastasis; thus, circ_0004296 might be a potential biomarker and therapeutic target for patients with PCa." 1 CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502-5p/KRAS and IGF2BP2/Myc axes. hsa_circ_0021735 hsa_circ_CD44 CircCD44 DOID:1612 breast cancer breast cancer RNA-seq up-regulated "CircCD44 promotes TNBC proliferation, migration, invasion and tumorigenesis at least partially by sponging miR-502-5p and interacting with IGF2BP2." 2 "Circular RNA CNOT2 knockdown regulates twist family BHLH transcription factor via targeting microRNA 409-3p to prevent breast cancer invasion, migration and epithelial-mesenchymal transition." - hsa_circ_CNOT2 CircCNOT2 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circular RNA CNOT2 knockdown regulates twist family BHLH transcription factor via targeting microRNA 409-3p to prevent breast cancer invasion, migration and epithelial-mesenchymal transition." 2 "CircRNF220, not its linear cognate gene RNF220, regulates cell growth and is associated with relapse in pediatric acute myeloid leukemia." - hsa_circ_RNF220 CircRNF220 DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, microarray" up-regulated "we characterized the function of circRNF220 and found that circRNF220 knockdown specifically inhibited proliferation and promoted apoptosis in AML cell lines and primary cells. Mechanistically, circRNF220 may act as an endogenous sponge of miR-30a to sequester miR-30a and inhibit its activity, which increases the expression of its targets MYSM1 and IER2 and implicated in AML relapse." 2 circNUDT21 promotes bladder cancer progression by modulating the miR-16-1-3p/MDM2/p53 axis. - hsa_circ_NUDT21 circNUDT21 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated CircNUDT21 promoted BC progression by acting as a sponge of miR-16-1-3p to activate the miR-16-1-3p/MDM2/p53 axis. 1 m6A modification of circHPS5 and hepatocellular carcinoma progression through HMGA2 expression. - hsa_circ_HPS5 circHPS5 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq, microarray" up-regulated circHPS5 can act as a miR-370 sponge to regulate the expression of HMGA2 and further accelerate HCC cell tumorigenesis. 1 Circular RNA circ-TNPO3 suppresses metastasis of GC by acting as a protein decoy for IGF2BP3 to regulate the expression of MYC and SNAIL. - hsa_circ_TNPO3 circ-TNPO3 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "circ-TNPO3 acts as a protein decoy for IGF2BP3 to regulate the MYC-SNAIL axis, thereby suppressing the proliferation and metastasis of GC." 1 circ_0067934 promotes the progression of papillary thyroid carcinoma cells through miR-1301-3p/HMGB1 axis. hsa_circ_0067934 - circ_0067934 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated circ_0067934 promotes the progression of papillary thyroid carcinoma cells through miR-1301-3p/HMGB1 axis. 1 Hsa_circ_0065217 promotes growth and metastasis of renal cancer through regulating the miR-214-3p-ALPK2 axis. hsa_circ_0065217 hsa_circ_SCAP - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated hsa_circ_0065217/miR-214-3p/ALPK2 signaling putatively promotes RCC tumorigenesis and is a putative RCC treatment target. 1 circ_0038718 promotes colon cancer cell malignant progression via the miR-195-5p/Axin2 signaling axis and also effect Wnt/beta-catenin signal pathway. hsa_circ_0038718 - circ_0038718 DOID:219 colon cancer colon cancer RT-qPCR up-regulated "circ_0038718 is able to facilitate CC cell malignant progression via the miR-195-5p/Axin2 axis, which will provide a new idea for finding a novel targeted treatment of CC." 1 "Circular RNA hsa_circ_0103552 Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells through Upregulating Cysteine-Rich Angiogenic Inducer 61 (CYR61) Expression via Sponging MicroRNA-515-5p." hsa_circ_0103552 hsa_circ_UBR1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circ_0103552 up-modulates CYR61 expression by targeting miR-515-5p and thus facilitates the multiplication, migration, and invasion of breast cancer cells." 3 Mechanism underlying circularRNA_014301-mediated regulation of neuronal cell inflammation and apoptosis. - - circRNA_014301 DOID:13743 spinal cord lipoma Spinal cord injury RT-qPCR up-regulated circRNA_014301 may represent a potential target for SCI diagnosis and therapy. 1 Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia progression through modulating B4GALT5 expression and PI3K/AKT signaling pathway. hsa_circ_0009910 - Circ_0009910 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "Circ_0009910 could suppress the proliferation, sphere formation, and autophagy and accelerated apoptosis by modulating B4GALT5 expression and activating the PI3K/AKT signaling pathway via sponging miR-491-5p in AML cells, suggesting that circ_0009910 might be a potential biomarker for the treatment of AML." 3 A novel tumour suppressor protein encoded by circMAPK14 inhibits progression and metastasis of colorectal cancer by competitively binding to MKK6. - hsa_circ_MAPK14 circMAPK14 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "circMAPK14 functioned as a tumour-suppressor by encoding circMAPK14-175aa, which blocked the progression and metastasis of colorectal cancer." 1 Circular RNA SOX13 promotes malignant behavior and cisplatin resistance in non-small cell lung cancer through targeting microRNA-3194-3p/microtubule-associated protein RP/EB family member 1. - hsa_circ_SOX13 circSOX13 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circSOX13 and the microtubule-associated protein RP/EB family member 1 (MAPRE1) were signally up-regulated in NSCLC while miR-3194-3p was signally lowered. 1 CircFAM120B knockdown inhibits osteosarcoma tumorigenesis via the miR-1205/PTBP1 axis. hsa_circ_0078767 hsa_circ_FAM120B CircFAM120B DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "We hypothesize circFAM120B functions as a miR-1205 sponge to elevate PTBP1 levels, enhancing OS progression and associated malignant phenotypes. " 3 EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression. - hsa_circ_PRKAR1B circPRKAR1B DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated circPRKAR1B exerted oncogenic roles in OS and suggested the circPRKAR1B/miR-361-3p/FZD4 axis plays an important role in OS progression and might be a potential therapeutic target. 1 CircETFA upregulates CCL5 by sponging miR-612 and recruiting EIF4A3 to promote hepatocellular carcinoma. - hsa_circ_ETFA CircETFA DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "CircETFA can increase the expression of CCL5 to promote the progression of HCC by sponging hsa-mir-612 and recruiting EIF4A3, and is promising as a novel biomarker and therapeutic target." 1 Doxorubicin inhibits osteosarcoma progression by regulating circ_0000006/miR-646/ BDNF axis. hsa_circ_0000006 - circ_0000006 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ_0000006 knockdown promoted DOX-mediated effects on OS development by miR-646/BDNF pathway, which provided a theoretical basis in treating OS with DOX." 2 Identification of circular RNAs hsa_circ_0140271 in peripheral blood mononuclear cells as a novel diagnostic biomarker for female rheumatoid arthritis. hsa_circ_0140271 hsa_circ_MED14 - DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "PBMC expression of hsa_circ_0140271 of female RA was significantly higher than that of female HC, and it was positively correlated with antistreptolysin (ASO)." 1 PBX2-Mediated circTLK1 Activates JAK/STAT Signaling to Promote Gliomagenesis via miR-452-5p/SSR1 Axis. - hsa_circ_TLK1 circTLK1 DOID:0060108 brain glioma gliomagenesis RT-qPCR up-regulated circTLK1 mediated by PBX2 activates JAK/STAT signaling to promote glioma progression through the miR-452-5p/SSR1 pathway. 2 CircFAM114A2 Promotes Cisplatin Sensitivity via miR-222-3p/P27 and miR-146a-5p/P21 Cascades in Urothelial Carcinoma. - hsa_circ_FAM114A2 CircFAM114A2 DOID:4006 bladder urothelial carcinoma urothelial carcinoma "RT-qPCR, RNA-seq" down-regulated CircFAM114A2 could inhibit progression and promote cisplatin sensitivity in urothelial carcinoma through novel circFAM114A2/miR-222-3p/P27 and circFAM114A2/miR-146a-5p/P21 pathways. 2 circ_0002346 Suppresses Non-Small-Cell Lung Cancer Progression Depending on the Regulation of the miR-582-3p/STXBP6 Axis. hsa_circ_0002346 - circ_0002346 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated circ_0002346 overexpression suppressed the malignant properties of NSCLC cells by binding to miR-582-3p to induce the expression of STXBP6. 2 circ_0001588 Induces the Malignant Progression of Hepatocellular Carcinoma by Modulating miR-874/CDK4 Signaling. hsa_circ_0001588 - circ_0001588 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ_0001588 acts as a ceRNA and promotes HCC progression by targeting the miR-874/CDK4 signaling pathway. 1 Circular RNA circSLC8A1 inhibits the proliferation and invasion of non-small cell lung cancer cells through targeting the miR-106b-5p /FOXJ3 axis. - hsa_circ_SLC8A1 circSLC8A1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "circSLC8A1 exhibits anti-tumor activity in NSCLC, which might be mediated by the miR-106b-5p/FOXJ3 axis." 1 Knockdown of circSMAD2 inhibits the tumorigenesis of gallbladder cancer through binding with eIF4A3. - hsa_circ_SMAD2 circSMAD2 DOID:3121 gallbladder cancer gallbladder cancer RT-qPCR up-regulated Knockdown of circSMAD2 inhibits the tumorigenesis of gallbladder cancer through binding with eIF4A3. 1 CircRFX3 contributes to glioma progression through the circRFX3-miR-1179/miR-1229-VASP axis. - hsa_circ_RFX3 CircRFX3 DOID:0060108 brain glioma glioma RT-qPCR up-regulated CircRFX3 served as a tumor promoter in glioma via modulating miR-1179/miR-1229-VASP axis. 2 Circulating circTOLLIP serves as a diagnostic biomarker for liquid biopsy in non-small cell lung cancer. - hsa_circ_TOLLIP circTOLLIP DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "CircTOLLIP was screened as a candidate biomarker and was found to be significantly down-regulated in both NSCLC tissues and cell lines. Interestingly, circulating circTOLLIP was also lower-expressed in the whole blood of patients with NSCLC compared to that of patients with benign lung disease and healthy controls." 1 circ-NOL10 regulated by MTDH/CASC3 inhibits breast cancer progression and metastasis via multiple miRNAs and PDCD4. - hsa_circ_NOL10 circ-NOL10 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated circ-NOL10 regulated by MTDH/CASC3 inhibits breast cancer progression and metastasis via multiple miRNAs and PDCD4. 4 Circ_0114427 promotes LPS-induced septic acute kidney injury by modulating miR-495-3p/TRAF6 through the NF-kappaB pathway. hsa_circ_0114427 - circ_0114427 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated Circ_0114427 regulates LPS-induced HK-2 cell injury by regulating miR-495-3p/TRAF6/NF-¦ĘB/p65 axis. 1 CircRNA has_circ_0001806 promotes hepatocellular carcinoma progression via the miR-193a-5p/MMP16 pathway. hsa_circ_0001806 hsa_circ_CSPP1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ_0001806 promoted HCC progression by regulating miR-193a-5p/MMP16 axis. 6 Circ-BNIP3L knockdown alleviates LPS-induced renal tubular epithelial cell injury during sepsis-associated acute kidney injury by miR-370-3p/MYD88 axis. - hsa_circ_BNIP3L circ-BNIP3L DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated "Circ-BNIP3L knockdown alleviated LPS-induced renal tubular epithelial cell injury by miR-370-3p/MYD88 axis, opening up a completely new avenue for the treatment of sepsis-associated AKI." 1 CircTLK1 Downregulation Attenuates High Glucose-Induced Human Mesangial Cell Injury by Blocking the AKT/NF-kappaB Pathway Through Sponging miR-126-5p/miR-204-5p. hsa_circ_0004442 hsa_circ_TLK1 circTLK1 DOID:9743 diabetic neuropathy Diabetic nephropathy RT-qPCR up-regulated "CircTLK1 downregulation alleviated HG-induced inflammation, oxidative stress, and ECM accumulation through blocking the AKT/NF-¦ĘB pathway via sponging miR-126-5p/miR-204-5p, providing a new mechanism to comprehend the pathogenesis of DN." 1 Circular RNA circ-ERBB2 promotes HER2-positive breast cancer progression and metastasis via sponging miR-136-5p and miR-198. - hsa_circ_ERBB2 circ-ERBB2 DOID:0060079 Her2-receptor positive breast cancer HER2-positive breast cancer RT-qPCR up-regulated Circ-ERBB2 accelerated HER2-positive breast cancer progression through the circ-ERBB2/miR-136-5p/TFAP2C axis or the circ-ERBB2/miR-198/TFAP2C axis. 1 CircADARB1 serves as a new biomarker in natural killer T-cell lymphoma and a potential regulator of p-Stat3. - hsa_circ_ADARB1 CircADARB1 DOID:50743 mature T-cell and NK-cell lymphoma natural killer/T-cell lymphoma "RT-qPCR, microarray" up-regulated The knockdown of circADARB1 inhibited proliferation of NKTCL cells in vitro and in vivo. CircADARB1 could bind to miR-214-3p in the downstream and regulate the expression of p-Stat3. 1 Hsa-circ_0058106 induces EMT and metastasis in laryngeal cancer via sponging miR-153 and inducing Twist1 nuclear translocation. hsa_circ_0058106 - circ_0058106 DOID:2600 laryngeal carcinoma laryngeal cancer RT-qPCR up-regulated hsa-circ_0058106 induces EMT and metastasis in laryngeal cancer by sponging miR-153 and inducing Twist1 nuclear translocation. 1 Knockdown of circular RNA septin 9 inhibits the malignant progression of breast cancer by reducing the expression of solute carrier family 1 member 5 in a microRNA-149-5p-dependent manner. - hsa_circ_SEPT9 circSEPT9 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circSEPT9 may act an oncogenic role in BC malignant progression by regulating miR-149-5p/SLC1A5 pathway, providing a novel mechanism responsible for BC development." 1 "Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis." - hsa_circ_MTO1 CircMTO1 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. 1 Circ_0039411 promotes papillary thyroid carcinoma development through mediating the miR-423-5p/SOX4 signaling. hsa_circ_0039411 - Circ_0039411 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated Circ_0039411 promoted the malignant behaviors of papillary thyroid carcinoma cells partly depending on the regulation of the miR-423-5p/SOX4 axis. 2 Upregulated circ_0002141 facilitates oral squamous cell carcinoma progression via the miR-1231/EGFR axis. hsa_circ_0002141 - circ_0002141 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated Upregulated circ_0002141 facilitates oral squamous cell carcinoma progression via the miR-1231/EGFR axis. 1 CircDLGAP4 overexpression relieves oxygen-glucose deprivation-induced neuronal injury by elevating NEGR1 through sponging miR-503-3p. - hsa_circ_DLGAP4 circDLGAP4 DOID:3526 cerebral infarction ischemic stroke RT-qPCR down-regulated CircDLGAP4 alleviated OGD-induced HCN-2 cell damage by regulating miR-503-3p/NEGR1 axis. 1 ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma. - hsa_circ_ciRS7 ciRS-7 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated ciRS-7 acts as a tumor promoter by regulating the miR-139-3p/TAGLN axis and activating the PI3K/AKT signaling pathway to promote RCC progression and metastasis. 1 Circ_0043532 regulates miR-182/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome. hsa_circ_0043532 - circ_0043532 DOID:11612 polycystic ovary syndrome Polycystic ovary syndrome RT-qPCR up-regulated Deficiency of circ_0043532 suppressed cell proliferation and induced cell cycle arrest and cell apoptosis in PCOS by modulation of miR-182/SGK3 axis. 2 Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer. hsa_circ_0082374 hsa_circ_CPA4 circCPA4 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircCPA4 could act as a sponge of miR-214-3p to upregulate TGIF2 expression, thereby promoting the progression of lung cancer cells." 2 Circ-RNF121 regulates tumor progression and glucose metabolism by miR-1224-5p/FOXM1 axis in colorectal cancer. - hsa_circ_RNF121 Circ-RNF121 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ-RNF121 and FOXM1 expression were dramatically upregulated, while miR-1224-5p expression was downregulated in CRC tissues or cells compared with control groups. Circ-RNF121 silencing repressed cell proliferation, migration, invasion and glycolysis but induced cell apoptosis in CRC, which were attenuated by miR-1224-5p inhibitor. " 1 Circular RNA circ_GLIS2 suppresses hepatocellular carcinoma growth and metastasis. - hsa_circ_GLIS2 circ_GLIS2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Circ_GLIS2 suppresses HCC growth and metastasis by inhibiting cell proliferation, migration, and invasion, but promoting cell apoptosis." 2 Circular RNA circPDSS1 promotes osteosarcoma progression by sponging miR-502-3p and miR-4436a. - hsa_circ_PDSS1 circPDSS1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circPDSS1 acts as a molecular sponge of miR-502-3p and miR-4436a regulates the proliferation and invasion of OS cells and promote the malignant progression of OS. 1 CircEpc1 Promotes Ricin Toxin-Induced Inflammation via Activation of NF-kappaB and MAPK Signaling Pathways by Sponging miR-5114. mmu_circ_0000842 mmu_circ_Epc1 circEpc1 DOID:0050132 inflammatory diarrhea inflammatory injury RT-qPCR down-regulated "Our results illuminated a link between RT-induced inflammation and the circEpc1 regulatory loop and provided novel insight into the functions of circRNA in innate immune, which may emerge as a potential target in immunotherapy to control the RT-induced inflammatory injury." 1 Circular RNA circ_0070441 regulates MPP(+)-triggered neurotoxic effect in SH-SY5Y cells via miR-626/IRS2 axis. hsa_circ_0070441 - circ_0070441 DOID:14330 Parkinson disease Parkinson disease RT-qPCR up-regulated circ_0070441 aggravated MPP+-triggered neurotoxic effect in SH-SY5Y cells by regulating miR-626/IRS2 axis. 1 CircMMP11 overexpression predicts the poor survival of non-small cell lung cancer and downregulates miR-143 through methylation to suppress cell proliferation. - hsa_circ_MMP11 CircMMP11 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircMMP11 overexpression predicts the poor survival of non-small cell lung cancer and downregulates miR-143 through methylation to suppress cell proliferation. 1 "Circ_0058106 promotes proliferation, metastasis and EMT process by regulating Wnt2b/beta-catenin/c-Myc pathway through miR-185-3p in hypopharyngeal squamous cell carcinoma." hsa_circ_0058106 hsa_circ_MMP11 Circ_0058106 DOID:8533 hypopharynx cancer hypopharyngeal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "our findings firstly confirmed the carcinogenic effect of circ_0058106 in promoting HSCC cells tumorigenesis, metastasis, invasion and EMT process by regulating Wnt2b/beta-catenin/c-Myc pathway through sponging miR-185-3p, indicating that circ_0058106 may be a new therapeutic target and prognostic marker for HSCC." 2 Knockdown of circular RNA VANGL1 inhibits TGF-beta-induced epithelial-mesenchymal transition in melanoma cells by sponging miR-150-5p. - hsa_circ_VANGL1 circVANGL1 DOID:1909 melanoma melanoma RT-qPCR up-regulated Knockdown of circular RNA VANGL1 inhibits TGF-beta-induced epithelial-mesenchymal transition in melanoma cells by sponging miR-150-5p. 1 Circular RNA circCTNNA1 is downregulated in osteoarthritis and sponges miR-29a to suppress LPS-induced apoptosis of synoviocytes. - hsa_circ_CTNNA1 circCTNNA1 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "CircCTNNA1 is downregulated in OA, and its overexpression suppresses synoviocyte apoptosis via sponging miR-29a." 1 "CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway." - mmu_circ_Prkcsh circPrkcsh DOID:13743 spinal cord lipoma Spinal cord injury RT-qPCR down-regulated Our research provides a better understanding of the mechanism of circPrkcsh in SCI and demonstrates that the circPrkcsh/miR-488/Mekk1 axis is a promising regulatory method for the treatment of SCI. 2 Circular RNA_0037128 aggravates high glucose-induced damage in HK-2 cells via regulation of microRNA-497-5p/nuclear factor of activated T cells 5 axis. hsa_circ_0037128 - circ_0037128 DOID:9743 diabetic neuropathy Diabetic nephropathy RT-qPCR up-regulated "Circ_0037128 downregulation could mitigate HG-stimulated cell damage via regulating the miR-497-5p/NFAT5 axis in HK-2 cells_n vitro, providing a possible therapy target for DN." 1 Circ_0000745 regulates NOTCH1-mediated cell proliferation and apoptosis in pediatric T-cell acute lymphoblastic leukemia through adsorbing miR-193b-3p. hsa_circ_0000745 hsa_circ_SPECC1 Circ_0000745 DOID:5603 T-cell acute lymphoblastic leukemia T-cell acute lymphoblastic leukemia RT-qPCR up-regulated circ_0000745 promoted cell proliferation and curbed cell apoptosis via upregulating NOTCH1 through serving as a miR-193b-3p sponge in T-ALL. 1 Cancer cell-derived exosomal circUSP7 induces CD8(+) T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC. - hsa_circ_USP7 circUSP7 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Exosomal circUSP7 is predominantly secreted by NSCLC cells and contributes to immunosuppression by promoting CD8(+) T cell dysfunction in NSCLC. CircUSP7 induces resistance to anti-PD1 immunotherapy, providing a potential therapeutic strategy for NSCLC patients." 1 Oncogenic circRNA C190 Promotes Non-Small Cell Lung Cancer via Modulation of the EGFR/ERK Pathway. hsa_circ_0000190 hsa_circ_CNIH4 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" up-regulated C190 is directly involved in EGFR-MAPK-ERK signaling and may serve as a potential therapeutic target for the treatment of NSCLC. 2 CircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events. - hsa_circ_VEGFC circVEGFC DOID:11714 gestational diabetes gestational diabetes mellitus RT-qPCR up-regulated "circVEGFC is highly expressed in GDM, and it is correlated with multiple adverse events." 1 CircRNA hsa_circ_0014130 function as a miR-132-3p sponge for playing oncogenic roles in bladder cancer via upregulating KCNJ12 expression. hsa_circ_0014130 hsa_circ_PIP5K1A - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated hsa_circ_0014130 works as a sponge of miR-132-3p to advance the oncogenesis and metastasis of bladder cancer by regulation of the KCNJ12 expression. 1 Regulation Effects of Circular RNA CircPVT1 and miR-125b on NF-kappaB Signal Pathway in Childhood ALL. - hsa_circ_PVT1 CircPVT1 DOID:9952 acute lymphoblastic leukemia acute lymphoblastic leukemia RT-qPCR up-regulated "CircPVT2 can promote ALL cell proliferation and invading through miR-125b modulation of NF-kappaB, which would be one new potential target for ALL therapy." 2 IL-6-induced cGGNBP2 encodes a protein to promote cell growth and metastasis in intrahepatic cholangiocarcinoma. hsa_circ_0003930 hsa_circ_GGNBP2 cGGNBP2 DOID:4928 intrahepatic cholangiocarcinoma intrahepatic cholangiocarcinoma "RT-qPCR, RNA-seq" up-regulated "Our study demonstrates that cGGNBP2-184aa, a protein encoded by IL-6-induced cGGNBP2, formed a positive feedback loop to facilitate ICC progression and may serve as an auxiliary target for clinical IL-6/STAT3-targeting treatments in ICC." 1 Integrative and in-vitro analysis reveal hsa_circ_001787 can act as a diagnostic biomarker for colorectal cancer. - - hsa_circ_001787 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated hsa_circ_001787 was significantly down-regulated in CRC. 1 CircRNA PLOD2 enhances ovarian cancer propagation by controlling miR-378. - hsa_circ_LOPD2 circ-LOPD2 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "circ-LOPD2 as a miR-378 sponge promotes the proliferation of ovarian cancer cells, which may in turn promote the development of OC." 1 HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer. - hsa_circ_CSPP1 circCSPP1 DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer. 1 [Effect and mechanism of circular RNA BICD2 on the biological behavior of oral squamous cell carcinoma cells]. - hsa_circ_BICD2 circ-BICD2 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Circ-BICD2 was highly expressed in OSCC cells. Interfering with circ-BICD2 could inhibit the proliferation, migration and invasion of OSCC cells, glutamine metabolism and tumor growth and promote cell apoptosis, which might be relate to the regulation of miR-296-5p/TAGLN2 molecular axis." 3 Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout. - - hsa_circRNA_103657 DOID:13189 gout primary gout "RT-qPCR, microarray" up-regulated "the expression levels of hsa_circRNA_103657 and hsa_circRNA_000241 were significantly higher in the gout group than those in the HC group, and both correlated significantly with lipid metabolism parameters." 1 Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout. - - hsa_circRNA_000241 DOID:13189 gout primary gout "RT-qPCR, microarray" up-regulated "the expression levels of hsa_circRNA_103657 and hsa_circRNA_000241 were significantly higher in the gout group than those in the HC group, and both correlated significantly with lipid metabolism parameters." 1 Circ_0000215 Exerts Oncogenic Function in Nasopharyngeal Carcinoma by Targeting miR-512-5p. hsa_circ_0000215 - Circ_0000215 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated Circ_0000215 is overexpressed in NPC and exerts oncogenic effects in NPC through regulating miR-512-5p/PIK3R1 axis. 1 Circ_0057583 facilitates brain microvascular endothelial cell injury through modulating miR-204-5p/NR4A1 axis. hsa_circ_0057583 - circ_0057583 DOID:178 vascular disease vascular endothelial injury RT-qPCR up-regulated Depletion of circ_0057583 alleviated LPS-triggered brain microvascular endothelial endothelial cell injury through modulating miR-204-5p/NR4A1 axis. 1 Hsa_circ_0003195 as a biomarker for diagnosis and prognosis of gastric cancer. hsa_circ_0003195 hsa_circ_TTC27 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated The expression of hsa_circ_0003195 was down-regulated in gastric cancer tissues and plasma from patients with gastric cancer. 1 RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis. hsa_circ_0000745 - circ_0000745 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated circ_0000745 upregulated by IGF2BP2 promotes aggressiveness and stemness of OC cells through a miR-3187-3p/ERBB4/PI3K/AKT axis. 1 Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis. - hsa_circ_PIP5K1A circPIP5K1A DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circular RNA circPIP5K1A contributed to cancer stemness of osteosarcoma by miR-515-5p/YAP axis. 1 CircESRP1 inhibits clear cell renal cell carcinoma progression through the CTCF-mediated positive feedback loop. - hsa_circ_ESRP1 CircESRP1 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, RNA-seq" down-regulated CircESRP1 inhibits clear cell renal cell carcinoma progression through the CTCF-mediated positive feedback loop. 1 Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis. - hsa_circ_IGF1R Circ-IGF1R DOID:8893 psoriasis psoriasis RT-qPCR up-regulated "circ-IGF1R-siRNA could inhibit the cell proliferation, migration and invasion, and induce apoptosis by regulating the miR-194-5p/CDK1 axis. circ-IGF1R may thus serve as a potential treatment target for psoriasis." 1 Angiogenesis is Inhibited by Arsenic Trioxide Through Downregulation of the CircHIPK3/miR-149-5p/FOXO1/VEGF Functional Module in Rheumatoid Arthritis. - hsa_circ_HIPK3 circHIPK3 DOID:848 arthritis arthritis RT-qPCR up-regulated "Thus, we elucidate a previously unknown mechanism between circRNAs and RA, and ATO has a significant protective effect on RA-FLS and CIA synovium_ia_ts inhibition of the angiogenic functional module of circHIPK3/miR-149-5p/FOXO1/VEGF, suggesting great potential for the combination therapy of ATO with circHIPK3 silencing." 1 "A Previously Undiscovered Circular RNA, circTNFAIP3, and Its Role in Coronavirus Replication." ssc_circ_0025549 ssc_circ_TNFAIP3 circTNFAIP3 DOID:0080599 Coronavirus infectious disease coronavirus "RT-qPCR, RNA-seq" up-regulated "In summary, we performed circRNA expression profiling in mock-infected and PDCoV-infected cells and characterized the novel differentially expressed circTNFAIP3 derived from the_NFAIP3_ene. We confirmed that circTNFAIP3 is strongly associated with various viral infections, especially by RNA viruses, and promotes deltacoronavirus replication via inhibiting apoptosis.." 1 Regulation of transforming growth factor-beta1 by circANKS1B/miR-515-5p affects the metastatic potential and cisplatin resistance in oral squamous cell carcinoma. hsa_circ_0007294 hsa_circ_ANKS1B circ_0007294 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "circANKS1B suppression elicited the anti-carcinogenic properties in OSCC cell invasion, migration, and cisplatin resistance by sponging miR-515-5p to block TGF-beta. Therefore, circANKS1B may act as an oncogenic gene to evoke TGF-beta signaling to participate in the development of OSCC." 1 Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1. hsa_circ_0080145 hsa_circ_TNS3 circ_0080145 DOID:8552 chronic myeloid leukemia chronic myeloid leukemia RT-qPCR up-regulated "This study established the signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1. The deregulation of circ_0080145 and circ_0051886 is, at least partially, responsible for the development of IM chemoresistance in CML by regulating expression of ABL1 via modulating expression of miR-203 and miR-637." 3 Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1. hsa_circ_0051886 hsa_circ_RPL13A circ_0051886 DOID:8552 chronic myeloid leukemia chronic myeloid leukemia RT-qPCR up-regulated "This study established the signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1. The deregulation of circ_0080145 and circ_0051886 is, at least partially, responsible for the development of IM chemoresistance in CML by regulating expression of ABL1 via modulating expression of miR-203 and miR-637." 1 Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer. hsa_circ_0007113 hsa_circ_HERC4 circHERC4 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "CircHERC4 exerts critical roles in promoting tumor aggressiveness through miR-556-5p/CTBP2/E-cadherin pathway and is a prognostic biomarker of the disease, suggesting that circHERC4 may serve as an exploitable therapeutic target for patients with CRC." 1 CircRNA-DOPEY2 enhances the chemosensitivity of esophageal cancer cells by inhibiting CPEB4-mediated Mcl-1 translation. hsa_circ_0008078 hsa_circ_DOPYE2 CircRNA-DOPEY2 DOID:5041 esophageal cancer esophageal cancer RT-qPCR down-regulated "We provide evidence that cDOPEY2 inhibits CPEB4-mediated Mcl-1 translation by promoting the ubiquitination and degradation of CPEB4 to alleviate cisplatin resistance, indicating that cDOPEY2 may serve as a valuable biomarker and potential therapeutic target in ESCC." 1 Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling. hsa_circ_0067835 hsa_circ_IFT80 Circ-IFT80 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "Circ-IFT80 may promote the malignant progression of ECa cells at least in part by modulating miR-545-3p/FAM98A axis, providing a potential therapeutic target for ECa." 2 "CircFOXM1 promotes the proliferation, migration, invasion, and glutaminolysis of glioblastoma by regulating the miR-577/E2F5 axis." hsa_circ_0025033 hsa_circ_FOXM1 CircFOXM1 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "Collectively, our results proposed that circFOXM1 was an upregulated circRNA in GBM, which could facilitate the proliferation, metastasis, and glutaminolysis of GBM through regulating the miR-577/E2F5 axis." 1 Circ_0046600 promotes hepatocellular carcinoma progression via up-regulating SERBP1 through sequestering miR-1258. hsa_circ_0046600 hsa_circ_B3GNTL1 Circ_0046600 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0046600 promoted HCC progression via up-regulating SERBP1 through sequestering miR-1258; besides that, circ_0046600 was packaged into exosomes and could be released from HCC cells." 2 Knockdown of circ-FURIN suppresses the proliferation and induces apoptosis of granular cells in polycystic ovary syndrome via miR-195-5p/BCL2 axis. - hsa_circ_FURIN circ-FURIN DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RT-qPCR up-regulated Circ-FURIN was upregulated in PCOS and GCs. Loss of circ-FURIN suppressed cell proliferation and facilitated apoptosis of KGN cells. The mechanism is associated with the miR-195-5p/BCL2 axis. 2 Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis. - hsa_circ_PLEKHM3 circ-PLEKHM3 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated Curcumin restrained proliferation and facilitated apoptosis in ovarian cancer by regulating the circ-PLEKHM3/miR-320a/SMG1 axis. 2 A Novel Circular RNA circPTCD3 Promotes Breast Cancer Progression Through Sponging miR-198. - hsa_circ_PTCD3 circPTCD3 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "To conclude, our findings shed light on the fact that circPTCD3 promotes the malignant behaviour of breast cancer by means of sponging miR-198, which indicates its potentiality to be a diagnostic or therapeutic target of breast cancer." 1 Knockdown of hsa_circ_0000729 Inhibits the Tumorigenesis of Non-Small Cell Lung Cancer Through Mediation of miR-1281/FOXO3 Axis. hsa_circ_0000729 hsa_circ_GAS8 circ_0000729 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Knockdown of hsa_circ_0000729 inhibits the tumorigenesis of NSCLC through mediation of miR-1281/FOXO3 axis. Thus, hsa_circ_0000729 might be served as a crucial mediator in NSCLC." 1 CircANTXR1 Contributes to the Malignant Progression of Hepatocellular Carcinoma by Promoting Proliferation and Metastasis. - hsa_circ_ANTXR1 CircANTXR1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircANTXR1 promotes the progression of HCC through the miR-532-5p/XRCC5 axis, which might be a potential serum biomarker and therapeutic target of HCC." 1 "Circular RNA UBR1 promotes the proliferation, migration, and invasion but represses apoptosis of lung cancer cells via modulating microRNA-545-5p/SSFA2 axis." - hsa_circ_UBR1 circ-UBR1 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "In summary, the study of miR-545-5p/SSFA2 axis elucidates the carcinogenic role of circ-UBR1 in the progression of LC. This mechanism may be beneficial to the cognition of the pathogenesis of LC." 1 Circular RNA cerebellar degeneration-related protein 1 antisense RNA (Circ-CDR1as) downregulation induced by dexmedetomidine treatment protects hippocampal neurons against hypoxia/reoxygenation injury through the microRNA-28-3p (miR-28-3p)/tumor necrosis factor receptor-associated factor-3 (TRAF3) axis. - hsa_circ_CDR1as Circ-CDR1as DOID:2316 brain ischemia cerebral ischemia/reperfusion injury RT-qPCR down-regulated This work demonstrated that DEX exerted neuroprotective effects against H/R-induced HT-22 cell dysfunction through regulating the circ-CDR1as/miR-28-3p/TRAF3 cascade.. 1 CircSLC7A6 promotes the progression of Wilm tumor via microRNA-107/ ABL proto-oncogene 2 axis. - hsa_circ_SLC7A6 CircSLC7A6 DOID:2154 nephroblastoma wilms tumor RT-qPCR up-regulated "It was the first time to determine the role of circSLC7A6 in WT, and we discovered that circSLC7A6 promoted WT progression via the miR-107/ABL2 axis, implying a novel and possible tactic for WT treatment." 1 Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis. hsa_circ_0048764 hsa_circ_RPL36 circ_0048764 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "In summary, circ_0048764 expression level is elevated in BC tissues and cell lines. In addition, circ_0048764 can expedite BC cell growth, migration, and invasion, and inhibit apoptosis via regulating the miR-1296-5p/TRIM14 axis. It is expected to provide new ideas for the diagnosing and treating BC." 2 Circular RNA CELF1 drives immunosuppression and anti-PD1 therapy resistance in non-small cell lung cancer via the miR-491-5p/EGFR axis. - hsa_circ_CELF1 circ_CELF1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Our data demonstrate that upregulation of circ_CELF1 elicits both oncogenic and immunoregulatory effects on the development of NSCLC. We believe that circ_CELF1 can act as a potential therapeutic target for the treatment of NSCLC. 1 The potential role of hsa_circ_0001079 in androgenetic alopecia via sponging hsa-miR-136-5p. hsa_circ_0001079 hsa_circ_STK39 circ_0001079 DOID:0050801 androgenic alopecia androgenetic alopecia "RT-qPCR, RNA-seq" up-regulated The relationship between hsa_circ_0001079 and AGA in this study suggests that hsa_circ_0001079 plays a key role in the occurrence and development of AGA. The reverse correlation and perfect binding sequence between hsa_circ_0001079 and miR_136_5p suggests that hsa_circ_0001079 might regulate Wnt5A mRNA to inhibit normal hair follicle growth through sponging adsorption of miR_136_5p and that Wnt5A also participates in multiple cellular DNA replication pathways.. 1 Knockdown of circFOXO3 ameliorates cigarette smoke-induced lung injury in mice. - mmu_circ_FOXO3 circFOXO3 DOID:850 lung disease cigarette smoke-induced lung injury RT-qPCR up-regulated "Collectively, these findings reveal a crucial function of circFOXO3 in the pathological remodeling related to CS-induced inflammatory processes. Hence, circFOXO3 might be a good target for the treatment of inflammatory disorders similar to CS-induced lung inflammation." 1 CircTP63 promotes cell proliferation and invasion by regulating EZH2 via sponging miR-217 in gallbladder cancer. hsa_circ_0068515 hsa_circ_TP63 CircTP63 DOID:3121 gallbladder cancer gallbladder cancer RT-qPCR up-regulated Our findings demonstrated that circTP63 sponged to miR-217 and regulated EZH2 expression and finally facilitated tumor progression in GBC.. 1 The inhibition of circular RNA circNOLC1 by propofol/STAT3 attenuates breast cancer stem cells function via miR-365a-3p/STAT3 signaling. - hsa_circ_NOLC1 circNOLC1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circNOLC1 contributed to CSCs properties and progression of breast cancer by targeting miR-365a-3p /STAT3 axis and propofol inhibited circNOLC1 by repressing STAT3 in a feedback mechanism. 1 A nanodrug system overexpressed circRNA_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p/miR-320a and ABCA1/CPT1 axis. hsa_circ_0001805 hsa_circ_CSPP1 circRNA_0001805 DOID:80208 non-alcoholic fatty liver disease nonalcoholic fatty liver disease RT-qPCR down-regulated "In summary, the present study revealed the protective role of circRNA_0001805 against NAFLD-induced fatty acid metabolism disorder and inflammation through the direct regulation of the miR-106a-5p/miR-320a/ABCA1/CPT1 axis. GA-RM/GZ/PL played a synergistic role against NAFLD-induced lipid metabolism disorder. By highlighting the potential value of circRNA_0001805 as a promising drug target for NAFLD treatment, our work provides deeper insight into ceRNA-mediated NAFLD pathogenesis and provides a new nanotherapy strategy for the treatment of NAFLD." 1 CircSETDB1 knockdown inhibits the malignant progression of serous ovarian cancer through miR-129-3p-dependent regulation of MAP3K3. hsa_circ_0006352 hsa_circ_SETDB1 CircSETDB1 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated CircSETDB1 silencing repressed SOC malignant progression through miR-129-3p/MAP3K3 pathway. This study supports circSETDB1 as a new therapeutic target for SOC. 3 "Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells." - hsa_circ_FNDC3B "Circ-FNDC3B," DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm RT-qPCR up-regulated circ-FNDC3B silencing ameliorated cytotoxicity triggered by Ang-II in VSMCs at least partially depending on the regulation of the miR-143-3p/ADAM10 axis. 1 Circular RNA circPHKA2 Relieves OGD-Induced Human Brain Microvascular Endothelial Cell Injuries through Competitively Binding miR-574-5p to Modulate SOD2. hsa_circ_0090002 hsa_circ_PHKA2 circPHKA2 DOID:936 brain disease Human Brain Microvascular Endothelial Cell Injuries RT-qPCR down-regulated "circPHKA2 could protect HBMEC against OGD-induced cerebral stroke model via the miR-574-5p/SOD2 axis, suggesting circPHKA2 as a novel and promising candidate in ischemic brain injury." 1 Construction of a competing endogenous RNA network related to the prognosis of cholangiocarcinoma and comprehensive analysis of the immunological correlation. hsa_circ_0002073 hsa_circ_TULP4 - DOID:4947 cholangiocarcinoma cholangiocarcinoma RNA-seq up-regulated "The study identified a novel prognostic marker of CCA, SLC16A3, and revealed the regulatory role of SLC16A3 in the tumor microenvironment, which is expected to provide new insights for the early diagnosis, prognosis, and targeted therapy of CCA." 1 Hsa_circ_NOTCH3 regulates ZNF146 through sponge adsorption of miR-875-5p to promote tumorigenesis of hepatocellular carcinoma. - hsa_circ_NOTCH3 circ_NOTCH3 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "As an oncogene, circ_NOTCH3 can trigger the proliferation, invasion, migration, and oxaliplatin resistance of HCC cells through the miR-875-5p/ZNF146 axis, and may be a promising target for the treatment of HCC." 1 Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205/CCND2 axis. hsa_circ_0006174 hsa_circ_RAD23B circ_0006174 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "To conclude, this study manifested that exosome-mediated delivery of circ_0006174 could confer DOX resistance to CRC cells via regulating the miR-1205/CCND2 signal pathway. Exosomal circ_0006174 can serve as a useful diagnostic target for DOX resistance.." 5 circ_TGFBR2 Inhibits Vascular Smooth Muscle Cells Phenotypic Switch and Suppresses Aortic Dissection Progression by Sponging miR-29a. - hsa_circ_TGFBR2 circ_TGFBR2 DOID:0080685 aortic dissection aortic dissection RT-qPCR down-regulated "In conclusion, our findings revealed that circ_TGFBR2 was down-regulated in AD on vivo and vitro level. Mechanistically, circ_TGFBR2 sponged miR-29a in AD-VSMC cells to regulate proliferation, migration and VSMCs phenotypic switch by affecting expression of target KLF4." 1 "Circ-METTL15 contributes to the proliferation, metastasis, immune escape and restrains apoptosis in lung cancer by regulating miR-1299/PDL1 axis." - hsa_circ_METTL15 Circ-METTL15 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Circ-METTL15 promoted lung cancer malignant progression at least partly through modulating PDL1 by sponging miR-1299. 1 Circ_0003204 knockdown protects endothelial cells against oxidized low-density lipoprotein-induced injuries by targeting the miR-491-5p-ICAM1 pathway. hsa_circ_0003204 - circ_0003204 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Circ_0003204 knockdown protects HUVECs against ox-LDL-induced injuries by targeting the miR-491-5p-ICAM1 pathway, hinting that circ_0003204 inhibition might prevent AS development." 7 Hsa_circ_0074032 promotes prostate cancer progression through elevating homeobox A1 expression by serving as a microRNA-198 decoy. hsa_circ_0074032 hsa_circ_SLC25A48 circ_0074032 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "The findings uncovered a novel mechanism by which circ_0074032 promoted PCa progression via elevating HOXA1 expression through acting as a miR-198 sponge, providing a mechanism for circ_0074032 to affect the development of PCa." 1 Circular RNA hsa_circ_0043278 inhibits breast cancer progression via the miR-455-3p/EI24 signalling pathway. hsa_circ_0043278 hsa_circ_TADA2A - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated Hsa_circ_0043278 acts as a tumour suppressor gene in BC through the hsa_circ_0043278/miR-455-3p/EI24 axis and may be regarded as a new prognostic predictor or potential therapeutic target in BC. 4 "CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition." - hsa_circ_SMAD4 circSMAD4 DOID:9743 diabetic neuropathy Diabetic nephropathy RT-qPCR down-regulated "CircSMAD4 alleviates HG-induced SV40-MES13 cell inflammation, ECM deposition and apoptosis by relieving miR-377-3p-mediated inhibition on BMP7 in DN progression." 1 Circ-PTPDC1 promotes the Progression of Gastric Cancer through Sponging Mir-139-3p by Regulating ELK1 and Functions as a Prognostic Biomarker. hsa_circ_008877 hsa_circ_PTPDC1 Circ-PTPDC1 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Our study identifies a new circular RNA, termed circ-PTPDC1 that is up-regulated in tumor tissues, cells and plasma of GC patients, and can act as a sponge of miR-139-3p to regulate the expression of ELK1. Our findings suggest that circ-PTPDC1 may be a novel potential circulating biomarker for the detection of GC." 1 Hsa_circRNA_103124 Upregulation in Crohn Disease Promotes Cell Proliferation and Inhibits Autophagy by Regulating the Hsa-miR-650/AKT2 Signaling Pathway. - - circRNA_103124 DOID:8778 Crohn disease Crohn disease RT-qPCR up-regulated These results indicate that hsa_circRNA_103124 upregulation in patients with CD promotes cell proliferation and inhibits autophagy by regulating the hsa-miR-650/AKT2 signaling pathway. 1 Construction of a circular RNA-microRNA-messenger RNA regulatory network of hsa_circ_0043256 in lung cancer by integrated analysis. hsa_circ_0043256 hsa_circ_ACACA - DOID:1324 lung cancer lung cancer RT-qPCR down-regulated Our study constructed a circRNA_miRNA_mRNA network of hsa_circ_0043256. hsa_circ_0043256 may be a potential therapeutic target for lung cancer. 2 CircMYOF triggers progression and facilitates glycolysis via the VEGFA/PI3K/AKT axis by absorbing miR-4739 in pancreatic ductal adenocarcinoma. - hsa_circ_MYOF CircMYOF DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" up-regulated "In summary, we identified a novel oncogenic circRNA-circMYOF in PDA. We also highlight that targeting the circMYOF/miR-4739/VEGFA/PI3K/AKT axis may be a promising strategy for the treatment of PDA. In the future, it is worthy investigating the potential regulatory mechanism on circMYOF expression." 1 circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis. - hsa_circ_KDM4C circKDM4C DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated "circKDM4C may act as a pro-oncogenic factor in BCa invasion and metastasis via the circKDM4C/miR-200bc-3p/ZEB1 axis, which is a potential biomarker or therapeutic target for bladder cancer." 1 Circ_0000463 contributes to the progression and glutamine metabolism of non-small-cell lung cancer by targeting miR-924/SLC1A5 signaling. hsa_circ_0000463 hsa_circ_EP400NL Circ_0000463 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0000463 absence suppressed the malignant behaviors and glutamine metabolism of NSCLC cells through mediating miR_924/SLC1A5 axis. 1 Circ-CREBBP promotes cell tumorigenesis and glutamine catabolism in glioma by regulating miR-375/glutaminase axis. - hsa_circ_CREBBP Circ-CREBBP DOID:0060108 brain glioma glioma RT-qPCR up-regulated "In conclusion, this research uncovered that circ-CREBBP exerted oncogenic role to promote glioma cell growth, migration, invasion and glutamine metabolism in vitro and imped tumor growth in nude mice via miR-375/GLS axis, elucidating the potential role of glutamine metabolism in cancer targeted therapies, which provided a novel insight into the development of novel therapeutic strategies for glioma patients." 1 Overexpression of circCDR1as drives oral squamous cell carcinoma progression. - hsa_circ_CDR1as circCDR1as DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated CircCDR1as acted as an oncogene in OSCC progression through elevating SLC7A11 by targeting miR-876-5p. 1 Circ_0030235 knockdown protects H9c2 cells against OGD/R-induced injury via regulation of miR-526b. hsa_circ_0030235 - Circ_0030235 DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR up-regulated This research implied that circ_0030235 knockdown might remit OGD/R-induced impacts via activation of PI3K/AKT and MEK/ERK pathways and regulation of miR-526b. 1 Circular RNA RBM33 contributes to extracellular matrix degradation via miR-4268/EPHB2 axis in abdominal aortic aneurysm. - hsa_circ_RBM33 circRBM33 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm "RT-qPCR, RNA-seq" up-regulated circRBM33 might be involved in AAA progression by regulating ECM degradation_ia_he miR-4268/EPHB2 axis. 1 Circ_0044556 Promotes the Progression of Colorectal Cancer via the miR-665-Dependent Expression Regulation of Diaphanous Homolog 1. hsa_circ_0044556 - Circ_0044556 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Our findings manifested that circ_0044556 functioned as an oncogenic circRNA in colorectal cancer by mediating the miR-665/Diaphanous Homolog 1 axis, elucidating the molecular mechanism of circ_0044556 in CRC progression." 2 Hsa_circ_0000527 Downregulation Suppresses the Development of Retinoblastoma by Modulating the miR-27a-3p/HDAC9 Pathway. hsa_circ_0000527 hsa_circ_FAM158A circ_0000527 DOID:768 retinoblastoma Retinoblastoma RT-qPCR up-regulated "hsa_circ_0000527 downregulation blocked the progression of RB by regulating the miR-27a-3p/HDAC9 pathway, which might be associated with the inactivation of the PI3K/AKT pathway." 5 Circular RNA circ_0023404 serves as a miR-636 sponge to promote malignant behaviors in cervical cancer cells through upregulation of CYP2S1. hsa_circ_0023404 - circ_0023404 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "our findings are the first to reveal the regulatory role of circ_0023404/miR-636/CYP2S1 axis in the regulation of cervical cancer progression (Figure8), providing a new potential therapeutic target for cervical cancer." 3 Circ-SFMBT2 facilitates the malignant growth of acute myeloid leukemia cells by modulating miR-582-3p/ZBTB20 pathway. - hsa_circ_SFMBT2 Circ-SFMBT2 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "Knockdown of circ-SFMBT2 suppressed AML progression by regulating the miR-582-3p/ZBTB20 axis, which might provide a potential therapeutic strategy for AML." 1 Circ_0092367 Inhibits EMT and Gemcitabine Resistance in Pancreatic Cancer via Regulating the miR-1206/ESRP1 Axis. hsa_circ_0092367 - Circ_0092367 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR down-regulated "Our findings show that circ_0092367 plays a crucial role in sensitizing PC cells to gemcitabine by modulating the miR-1206/ESRP1 axis, highlighting its potential as a valuable therapeutic target in PC patients." 1 CircNFIC Balances Inflammation and Apoptosis by Sponging miR-30e-3p and Regulating DENND1B Expression. - gga_circ_NFIC CircNFIC DOID:0050117 disease by infectious agent Disordered inflammation and apoptosis RT-qPCR up-regulated circNFIC promoted cell inflammation and apoptosis via the miR-30e-3p/DENND1B axis. 1 Circ_0084443 Inhibits Wound Healing Via Repressing Keratinocyte Migration Through Targeting the miR-17-3p/FOXO4 Axis. hsa_circ_0084443 - Circ_0084443 DOID:37 skin disease skin wound healing RT-qPCR down-regulated "These results exhibited that circ_0084443 suppressed the TGF-beta1-induced keratinocyte migration by regulating the miR-17-3p/FOXO4 axis, suggesting the application potential of circ_0084443 in wound-healing-related diseases." 1 Circular RNA circ_0000517 Facilitates The Growth and Metastasis of Non-Small Cell Lung Cancer by Sponging miR-326/miR-330-5p. hsa_circ_0000517 - circ_0000517 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "This work reveals that_irc_0000517_s implicated in NSCLC cell growth and metastasis through the modulation of miR-326/miR-330-5p/MMP2, providing novel insights into the role of circRNAs in NSCLC progression." 2 Circ_MUC16 attenuates the effects of Propofol to promote the aggressive behaviors of ovarian cancer by mediating the miR-1182/S100B signaling pathway. - hsa_circ_MUC16 Circ_MUC16 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated Circ_MUC16 overexpression alleviated the effects of Propofol to promote the aggressive behaviors of ovarian cancer by targeting the miR-1182/S100B network. 1 The circular RNA hsa_circ_000780 as a potential molecular diagnostic target for gastric cancer. - - hsa_circ_000780 DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated "The present study uncovered a new circRNA expression profile in human GC, with hsa_circ_000780 significantly downregulated in GC tissue and gastric fluid specimens. These findings indicate that hsa_circ_000780 should be considered a novel biomarker for early GC screening." 1 PESV represses non-small cell lung cancer cell malignancy through circ_0016760 under hypoxia. hsa_circ_0016760 - circ_0016760 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0016760 overexpression counteracted PESV-induced repression of NSCLC cell malignancy and angiogenesis under hypoxia through miR-29b/HIF1A axis. 6 Amplification of spatially isolated adenosine pathway by tumor-macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma. - hsa_circ_TMEM181 circTMEM181 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "In summary, HCC-derived exosomal circTMEM181 contributes to immunosuppression and anti-PD1 resistance by elevating CD39 expression, and inhibiting the ATP-adenosine pathway by targeting CD39 on macrophages can rescue anti-PD1 therapy resistance in HCC." 2 Circular RNA circVAPA contributes to non-small-cell lung cancer progression via miR-342-3p-dependent regulation of ZEB2. - hsa_circ_VAPA circVAPA DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircVAPA contributes to the progression of NSCLC by binding to miR-342-3p to upregulate ZEB2. CircVAPA/miR-342-3p/ZEB2 axis might be a novel potential target for NSCLC treatment. 2 Hsa_circ_0001666 suppresses the progression of colorectal cancer through the miR-576-5p/PCDH10 axis. hsa_circ_0001666 hsa_circ_FAM120B circ_0001666 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated Hsa_circ_0001666 suppresses CRC progression through the miR-576-5p/PCDH10 axis and may provide a new insight for the diagnosis and treatment of CRC. 2 The circular RNA circSLC7A11 functions as a mir-330-3p sponge to accelerate hepatocellular carcinoma progression by regulating cyclin-dependent kinase 1 expression. - hsa_circ_SLC7A11 circSLC7A11 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated The acceleration of HCC progression and metastasis by circSLC7A11 through the circSLC7A11/miR-330-3p/CDK1 axis suggests that circSLC7A11 is a potential novel diagnostic and therapeutic target for HCC treatment. 1 Circ_0005033 is an oncogene in laryngeal squamous cell carcinoma and regulates cell progression and Cisplatin sensitivity via miR-107/IGF1R axis. hsa_circ_0005033 - Circ_0005033 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated Circ_0005033 was oncogenic in LSCC by regulating cell progression and Cisplatin sensitivity at least via miR-107/IGF1R axis. 1 CircATXN7 contributes to the progression and doxorubicin resistance of breast cancer via modulating miR-149-5p/HOXA11 pathway. - hsa_circ_ATXN7 CircATXN7 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Interference of circATXN7 inhibited breast cancer progression and doxorubicin resistance via mediating miR-149-5p/HOXA11 axis, which might provide a possible biomarker for breast cancer therapy." 1 "Upregulation of circRNA hsa_circ_0008726 in Pre-eclampsia Inhibits Trophoblast Migration, Invasion, and EMT by Regulating miR-345-3p/RYBP Axis." hsa_circ_0008726 hsa_circ_DNAJB6 circ_0008726 DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated "Our data demonstrate the upregulation of circ_0008726 in PE placenta, which inhibits the migration, invasion, and EMT of HTR-8/SVneo cells by targeting miR-345-3p/RYBP axis. These data suggest that circ_0008726 could be a potential biomarker and therapeutic target for PE." 1 Hsa_circ_0007059 sponges miR-421 to repress cell growth and stemness in hepatocellular carcinoma by the PTEN-AKT/mTOR pathway. hsa_circ_0007059 hsa_circ_ZNF720 circ_0007059 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated Circ_0007059 sponges miR-421 to inhibit oncogenic cellular process in HCC by mediating the PTEN-AKT/mTOR pathway. 1 CircCRIM1 promotes ovarian cancer progression by working as ceRNAs of CRIM1 and targeting miR-383-5p/ZEB2 axis. - hsa_circ_CRIM1 CircCRIM1 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "CircCRIM1 bond with miR-145-5p to work as competing endogenous RNA (ceRNA) of CRIM1, and circCRIM1 bond with miR-383-5p to improve the expression of ZEB2 in ovarian cancer. CircCRIM1 and CRIM1 promoted the ovarian cancer progression and supplied a novel insight into the researches of ovarian cancer." 1 Circ_UTRN ameliorates caerulein-induced acute pancreatitis in vitro via reducing inflammation and promoting apoptosis through miR-320-3p/PTK2 axis. - hsa_circ_UTRN Circ_UTRN DOID:2913 acute pancreatitis acute pancreatitis RT-qPCR down-regulated "Up-regulation of circ_UTRN in pancreatic acinar cells attenuates caerulein-evoked cell apoptosis arrest and inflammation enhancement via miR-320-3p/PTK2, suggesting that circ_UTRN/miR-320-3p/PTK2 axis might be engaged in caerulein-induced AP." 1 CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer. hsa_circ_0008037 - circ_0008037 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0008037 accelerated tumor growth and elevated the Warburg effect via regulating NUCKS1 expression by adsorbing miR-433-3p, providing an underlying target for NSCLC treatment." 1 "CircAKT3 promotes cell proliferation, survival and glutamine metabolism of gastric cancer by activating SLC1A5 expression via targeting miR-515-5p." - hsa_circ_AKT3 CircAKT3 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircAKT3 promotes the malignant development of GC by activating SLC1A5 expression via targeting miR-515-5p. 4 CircSmg5 stimulates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting the miR-194-5p/Fzd6 axis and beta-catenin signaling. - hsa_circ_Smg5 CircSmg5 DOID:0080001 bone disease bone disease RT-qPCR up-regulated circSmg5 was demonstrated to promote the BMSC osteogenic differentiation by targeting the miR-194-5p/Fzd6 axis to activate the Wnt/beta-catenin signaling. 1 Hsa_circ_0030586 promotes epithelial-mesenchymal transition in prostate cancer via PI3K-AKT signaling. hsa_circ_0030586 hsa_circ_ABCC4 circ_0030586 DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated Hsa_circ_0030586 is significantly upregulated in PCa cells and may promote EMT via PI3K-AKT signaling. 2 A novel circRNA-miRNA-mRNA network revealed exosomal circ-ATP10A as a biomarker for multiple myeloma angiogenesis. - hsa_circ_ATP10A circ-ATP10A DOID:9538 multiple myeloma multiple myeloma angiogenesis "RT-qPCR, RNA-seq" up-regulated "Collectively, our study indicates that exosomal circ-ATP10A is a valuable prognostic biomarker in MM and may promote MM angiogenesis by targeting hsa-miR-6758-3p/hsa-miR-3977/hsa-miR-6804-3p/hsa-miR-1266-3p/hsa-miR-3620-3p and modulating their downstream mRNAs, such as VEGFB, HIF1A, PDGF, and FGF." 1 Downregulated circular RNA hsa_circ_0005797 inhibits endometrial cancer by modulating microRNA-298/Catenin delta 1 signaling. hsa_circ_0005797 hsa_circ_ATP2C1 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "In conclusion, our study confirmed hsa_circ_0005797 is a poor prognostic factor for EC and modulates EC phenotypes by regulating the hsa_circ_000579/miR-298/CTNND1 signaling, which provides potential treatment targets for EC." 1 Circular RNA circFLNA inhibits the development of bladder carcinoma through microRNA miR-216a-3p/BTG2 axis. - hsa_circ_FLNA circFLNA DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "In conclusion, circFLNA inhibits the malignant phenotype of BCa cells and their stemness through miR-216a-3p/BTG2, thus suppressing BCa progression." 2 CircEAF2 counteracts Epstein-Barr virus-positive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/beta-catenin axis. - hsa_circ_EAF2 CircEAF2 DOID:707 B-cell lymphoma B-cell lymphoma RT-qPCR down-regulated "CircEAF2 counteracted EBV + DLBCL progression via miR-BART19-3p/APC/beta-catenin axis, referring circEAF2 as a potential prognostic biomarker. Therapeutic targeting EBV-encoded miRNA may be a promising strategy in treating EBV-associated lymphoid malignancies." 1 "Mesenchymal Stem Cell-Originated Exosomal Circular RNA circFBXW7 Attenuates Cell Proliferation, Migration and Inflammation of Fibroblast-Like Synoviocytes by Targeting miR-216a-3p/HDAC4 in Rheumatoid Arthritis." - hsa_circ_FBXW7 circFBXW7 DOID:7148 rheumatoid arthritis rheumatoid arthritis RNA-seq dysregulated "MSC-derived exosomal circFBXW7 suppressed proliferation, migration and inflammatory response of RA-FLSs and damage of RA rats via sponging miR-216a-3p and release the activation of HDAC4. These findings may provide a novel therapeutic target for RA." 1 hsa_circ_0013401 Accelerates the Growth and Metastasis and Prevents Apoptosis and Autophagy of Neuroblastoma Cells by Sponging miR-195 to Release PAK2. hsa_circ_0013401 hsa_circ_CLCC1 circ_0013401 DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated "hsa_circ_0013401 induced NB progression through miR-195 to enhance PAK2. Therefore, we might highlight a novel regulatory axis (hsa_circ_0013401/miR-195/PAK2) in NB." 1 circ_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway. hsa_circ_0003949 hsa_circ_PTN circ_PTN DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "To conclude, our study unveiled the influence of circ_PTN on the DDP resistance of GBM cells, which might provide a therapeutic target for GBM treatment via DDP." 1 Circ_0059354 aggravates the progression of papillary thyroid carcinoma by elevating ARFGEF1 through sponging miR-766-3p. hsa_circ_0059354 hsa_circ_RASSF2 Circ_0059354 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated Circ_0059354 served as an oncogene in PTC progression through regulating miR-766-3p/ARFGEF1 axis. 2 "Hsa_circ_0008434 regulates USP9X expression by sponging miR-6838-5p to promote gastric cancer growth, migration and invasion." hsa_circ_0008434 hsa_circ_UQCRC2 circ_0008434 DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated "Hsa_circ_0008434 may promote GC proliferation, invasion and migration by regulating the expression of miR-6838 and USP9X." 1 Circ-ATAD1 is overexpressed in osteosarcoma (OS) and suppresses the maturation of miR-154-5p to increase cell invasion and migration. - hsa_circ_ATAD1 Circ-ATAD1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circ-ATAD1 is overexpressed in OS and suppresses miR-154-5p maturation to increase cell invasion and migration. 1 Microarray Identifies a Key Carcinogenic Circular RNA 0008594 That Is Related to Non-Small-Cell Lung Cancer Development and Lymph Node Metastasis and Promotes NSCLC Progression by Regulating the miR-760-Mediated PI3K/AKT and MEK/ERK Pathways. hsa_circ_0008594 - circ_0008594 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated "Our study identifies several valuable circRNAs related to NSCLC development and LNM. Furthermore, as a key functional circRNA, circ_0008594 was observed to promote NSCLC progression by regulating the miR-760-mediated PI3K/AKT and MEK/ERK pathways." 1 Evaluation of plasma circ_0006282 as a novel diagnostic biomarker in colorectal cancer. - - circ_0006282 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated Plasma hsa_circ_0006282 can be used as a novel diagnostic and dynamic monitoring biomarker in CRC patients. 1 Circ_SETD3 regulates gefitinib sensitivity and tumor progression by miR-873-5p-dependent regulation of APPBP2 in non-small cell lung cancer. - hsa_circ_SETD3 Circ_SETD3 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_SETD3 knockdown improved gefitinib sensitivity and repressed NSCLC cell malignancy via miR-873-5p/APPBP2 axis, which provides a theoretical basis for using circ_SETD3-based therapeutic strategies to improve NSCLC sensitivity to gefitinib." 3 A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/beta-catenin signaling pathway to promote gastric cancer progression. - hsa_circ_AXIN1 circAXIN1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "CircAXIN1 encodes a novel protein, AXIN1-295aa. AXIN1-295aa functions as an oncogenic protein, activating the Wnt signaling pathway to promote GC tumorigenesis and progression, suggesting a potential therapeutic target for GC." 1 Circ-FBXW12 aggravates the development of diabetic nephropathy by binding to miR-31-5p to induce LIN28B. - hsa_circ_FBXW12 circ-FBXW12 DOID:9743 diabetic neuropathy diabetic nephropathy RT-qPCR up-regulated "Circ-FBXW12 knockdown suppressed HG-induced HMC growth, inflammation, ECM accumulation and oxidative stress by regulating miR-31-5p/LIN28B axis." 1 Hypoxia-induced ebv-circLMP2A promotes angiogenesis in EBV-associated gastric carcinoma through the KHSRP/VHL/HIF1alpha/VEGFA pathway. - hsa_circ_LMP2A ebv-circLMP2A DOID:3717 gastric adenocarcinoma EBV-associated gastric carcinoma RT-qPCR up-regulated Ebv-circLMP2A was essential in regulating tumor angiogenesis in EBVaGC and might provide a valuable therapeutic target for EBVaGC. 1 LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis. - hsa_circ_ANKHD1 circANKHD1 DOID:4006 bladder urothelial carcinoma bladder urothelial carcinoma RT-qPCR up-regulated "LRPPRC exerts critical roles in regulating UCB redox homeostasis and tumorigenesis, and is a prognostic factor for UCB; suggesting that LRPPRC may serve as an exploitable therapeutic target in UCB." 1 Circular RNA circ_0062019 exerts oncogenic properties in prostate cancer via mediating miR-1253/NRBP1 axis. hsa_circ_0062019 - circ_0062019 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated circ_0062019 expedited PCa progression through mediating miR-1253/NRBP1 pathway. 3 "Exosomal circular RNA hsa_circ_007293 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through regulation of the microRNA-653-5p/paired box 6 axis." - - hsa_circ_007293 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "These results evidenced that exosomal circ007293 induced EMT and augmented the invasive and migratory abilities of PTC cells via the miR-653-5p/PAX6 axis, suggesting that it may serve as a promising biomarker for cancer progression." 1 CircNUP98 Suppresses the Maturation of miR-519a-3p in Glioblastoma. - hsa_circ_NUP98 CircNUP98 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "CircNUP98 contributed to larger tumors, which resulted in significantly reduced mice survival. CircNUP98 suppresses the maturation of miR-519a-3p to promote GB cell proliferation." 1 The circRAB3IP Mediated by eIF4A3 and LEF1 Contributes to Enzalutamide Resistance in Prostate Cancer by Targeting miR-133a-3p/miR-133b/SGK1 Pathway. - hsa_circ_RAB3IP circRAB3IP DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "circRAB3IP partially exerted its biological functions_ia_GK1 signaling. Furthermore, we discovered that eIF4A3 and LEF1 might increase circRAB3IP expression in PCa." 1 "The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells." hsa_circ_0001367 - Circ_0001367 DOID:0060108 brain glioma glioma RT-qPCR down-regulated the results of this study demonstrate that the circ_0001367/miR-545-3p/LUZP1 axis may be a novel target for glioma therapy. 2 CircCRIM1 Promotes Hepatocellular Carcinoma Proliferation and Angiogenesis by Sponging miR-378a-3p and Regulating SKP2 Expression. - hsa_circ_CRIM1 CircCRIM1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circCRIM1 boosts the HCC progression via the miR-378-3p/SKP2 axis and may act as a crucial epigenetic therapeutic molecule target in HCC. 2 The role of circular RNA plasmacytoma variant translocation 1 as a biomarker for prognostication of acute myeloid leukemia. - hsa_circ_PVT1 Circ-PVT1 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated Circ-PVT1 potentially serves as a biomarker for evaluating the prognosis of AML patients. 2 Hsa_circ_0001879 promotes the progression of atherosclerosis by regulating the proliferation and migration of oxidation of low density lipoprotein (ox-LDL)-induced vascular endothelial cells via the miR-6873-5p-HDAC9 axis. hsa_circ_0001879 hsa_circ_NIPSNAP3A circ_0001879 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated hsa_circ_0001879 decreased the proliferation and migration of HUVECs by inhibiting miR-6873-5p-induced HDAC9 degradation. 1 CircTUBGCP3 facilitates the tumorigenesis of lung adenocarcinoma by sponging miR-885-3p. - hsa_circ_TUBGCP3 CircTUBGCP3 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "Our findings demonstrated that circTUBGCP3 promoted LAC progression by sponging miR-885-3p, and might represent a prognostic factor for LAC." 1 Circular RNA circRPPH1 promotes breast cancer progression via circRPPH1-miR-512-5p-STAT1 axis. - hsa_circ_RPPH1 circRPPH1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "these findings indicated that circRPPH1 acted as an oncogene and regulated BC progression via circRPPH1-miR-512-5p-STAT1 axis, which might provide a potential therapeutic target for BC treatment." 9 CircRNA-001241 mediates sorafenib resistance of hepatocellular carcinoma cells by sponging miR-21-5p and regulating TIMP3 expression. - - CircRNA-001241 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "our study elucidated the oncogenic role of circ-001241 in mediating sorafenib resistance in HCC, providing insights and opportunities to overcome sorafenib resistance in patients with advanced hepatocellular carcinoma." 1 CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis. - hsa_circ_DOCK1 CircDOCK1 DOID:3347 osteosarcoma osteogenic sarcoma RT-qPCR up-regulated "CircDOCK1 can promote progression and regulate cisplatin sensitivity in OS via the miR-339-3p/IGF1R axis. Thus, the circDOCK1/miR-339-3p/IGF1R axis may be a key mechanism and therapeutic target in OS." 4 Down-regulation of circular RNA CDC14A peripherally ameliorates brain injury in acute phase of ischemic stroke. - hsa_circ_CDC14A circCDC14A DOID:6713 cerebrovascular disease stroke RT-qPCR up-regulated "Knocking down the expression of circCDC14A in peripheral blood cells relieved astrocytes activation in peri-infarct cortex, thereby relieved brain damage in the acute phase of ischemic stroke." 2 Using Circ-ANAPC7 as a Novel Type of Biomarker in the Monitoring of Acute Myeloid Leukemia. - hsa_circ_ANAPC7 Circ-ANAPC7 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated circ-ANAPC7 was upregulated in newly diagnosed and relapsed AML. It may serve as potential biomarkers for AML patients diagnosis and monitoring. 2 Circular RNA Foxo3 Relieves Myocardial Ischemia/Reperfusion Injury by Suppressing Autophagy via Inhibiting HMGB1 by Repressing KAT7 in Myocardial Infarction. - rno_circ_Foxo3 circFoxo3 DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated Our finding provides new insight into the mechanism by which circFoxo3 regulates MI-related cardiac dysfunction by targeting KAT7/HMGB1 axis. 1 Knockdown of Circular Ubiquitin-specific Peptidase 9 X-Linked Alleviates Oxidized Low-density Lipoprotein-induced Injuries of Human Umbilical Vein Endothelial Cells by Mediating the miR-148b-3p/KLF5 Signaling Pathway. - hsa_circ_USP9X circUSP9X DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "In conclusion, circUSP9X knockdown relieved ox-LDL-triggered HUVEC injuries during AS progression partly by mediating the miR-148b-3p/KLF5 network." 2 Interfering hsa_circ_0073748 alleviates caerulein-induced ductal cell injury in acute pancreatitis by inhibiting miR-132-3p/TRAF3/NF-kappaB pathway. hsa_circ_0073748 hsa_circ_LMNB1 circ_0073748 DOID:2913 acute pancreatitis acute pancreatitis RT-qPCR up-regulated circ_0073748/miR-132-3p/TRAF3 ceRNA pathway might be one underlying mechanism and therapeutic target of caerulein-induced AP. 1 Genome-wide map of N(6)-methyladenosine circular RNAs identified in mice model of severe acute pancreatitis. - - N6-methyladenosine circular RNAs DOID:2913 acute pancreatitis severe acute pancreatitis "RT-qPCR, RNA-seq" dysregulated m6A modification of circRNAs may be involved in the pathogenesis of SAP. Our findings may provide novel insights to explore the possible pathogenetic mechanism of SAP and seek new potential therapeutic targets for SAP. 1 Therapeutic Potential of Exosomal circRNA Derived from Synovial Mesenchymal Cells via Targeting circEDIL3/miR-485-3p/PIAS3/STAT3/VEGF Functional Module in Rheumatoid Arthritis. - hsa_circ_EDIL3 circEDIL3 DOID:848 arthritis arthritis RT-qPCR down-regulated The intracellular transfer of circEDIL3 by SMSCs-Exos may be a potential novel therapeutic strategy for RA. 1 Circular RNA CREBBP Suppresses Hepatic Fibrosis Via Targeting the hsa-miR-1291/LEFTY2 Axis. - hsa_circ_CREBBP circCREBBP DOID:409 liver disease hepatic fibrosis "RT-qPCR, microarray" down-regulated "In conclusion, our current results reveal a novel mechanism by which circCREBBP alleviates liver fibrosis by targeting the hsa-miR-1291/LEFTY2 axis, and also suggest that circCREBBP may be a potential biomarker for heart failure." 1 circ_0075943 Dominates the miR-141-3p/AK2 Network to Support the Development of Breast Carcinoma. - - circ_0075943 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated The abnormal regulation of circ_0075943 participates in part of the expansion of BC by dominating the miR-141-3p/AK2 regulatory network. 1 Methyltransferase-Like 3-Mediated m6A Methylation of Hsa_circ_0058493 Accelerates Hepatocellular Carcinoma Progression by Binding to YTH Domain-Containing Protein 1. hsa_circ_0058493 hsa_circ_RHBDD1 circ_0058493 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Taken together, this study explored the oncogenic role of m6A-modified hsa_circ_0058493 and found to accelerate HCC progression via the METTL3-hsa_circ_0058493-YTHDC1 axis, indicating a potential therapeutic target for this deadly disease." 2 Circular RNA_0000326 promotes bladder cancer progression via microRNA-338-3p/ETS Proto-Oncogene 1/phosphoinositide-3 kinase/Akt pathway. hsa_circ_0000326 - circ_0000326 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated circ_0000326/miR-338-3p/ETS1/PI3K/AKT pathway is involved in regulating BC progression. 1 hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR-139-3p/CCL5 axis. hsa_circ_0003410 hsa_circ_UBAP2 circ_0003410 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq up-regulated "Taken together, our experiments revealed that noncoding RNAs play a critical role in the HCC microenvironment and can be considered as markers for the diagnosis and prognosis of HCC." 4 Circular RNA circCCNT2 is upregulated in the anterior cingulate cortex of individuals with bipolar disorder. - hsa_circ_CCNT2 circCCNT2 DOID:3312 bipolar disorder bipolar disorder "RT-qPCR, RNA-seq" up-regulated our study is the first to associate circCCNT2 to bipolar disorder and lithium treatment. 1 CircVMA21 ameliorates lipopolysaccharide (LPS)-induced HK-2 cell injury depending on the regulation of miR-7-5p/PPARA. - hsa_circ_VMA21 CircVMA21 DOID:557 kidney disease sepsis-engendered acute kidney injury RT-qPCR down-regulated CircVMA21 overexpression alleviated LPS-stimulated HK2 cell damage through the regulation of miR-7-5p/PPARA. 1 Tanshinone IIA sodium sulfonate attenuates inflammation by upregulating circ-Sirt1 and inhibiting the entry of NF-kappaB into the nucleus. - hsa_circ_Sirt1 circ-Sirt1 DOID:0050117 disease by infectious agent Inflammation RT-qPCR down-regulated TSS is a potential treatment for inflammation. 1 "Circular RNA circ_0000423 promotes gastric cancer cell proliferation, migration and invasion via the microR-582-3p/Disheveled-Axin domain containing 1 axis." hsa_circ_0000423 - circ_0000423 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circ_0000423 facilitates GC progression by modulating the miR-582-3p/DIXDC1 axis. 1 "YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1." - hsa_circ_ZNF609 circ-ZNF609 DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR up-regulated "YY1/eIF4A3/circ-ZNF609/miR-432-5p/LRRC1 have a significant role in progression of cholangiocarcinoma, and circ-ZNF609 is expected to become a novel biomarker for targeted therapy and prognosis evaluation of cholangiocarcinoma." 1 CircARVCF Contributes to Cisplatin Resistance in Gastric Cancer by Altering miR-1205 and FGFR1. - hsa_circ_ARVCF CircARVCF DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircARVCF enhanced DDP resistance in GC by elevating FGFR1 through sponging miR-1205. 1 CircRNF13 Promotes the Malignant Progression of Pancreatic Cancer through Targeting miR-139-5p/IGF1R Axis. - hsa_circ_RNF13 CircRNF13 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated CircRNF13 serves as a competitive endogenous RNA of IGF1R to inhibit the function of miR-139-5p that eventually reinforces the malignant phenotype of PC. 2 Circular RNA Circ_0000098 Elevates ALX4 Expression via Adsorbing miR-1204 to Inhibit the Progression of Hepatocellular Carcinoma. hsa_circ_0000098 - Circ_0000098 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0000098, as a competitive endogenous RNA (ceRNA) of miR-1204, upregulates ALX4 expression and suppresses the growth, migration, invasion, and EMT of HCC cells." 4 circHUWE1 Exerts an Oncogenic Role in Inducing DDP-Resistant NSCLC Progression Depending on the Regulation of miR-34a-5p/TNFAIP8. - hsa_circ_HUWE1 circHUWE1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circHUWE1 functioned as a promoter in DDP-resistant NSCLC by interaction with miR-34a-5p-TNFAIP8 networks, providing novel insight into DDP-resistant NSCLC diagnosis and treatment." 2 hsa_circ_0023305 Enhances Laryngeal Squamous Cell Carcinoma Progression and Modulates TRPM7 via miR-218-5p Sponging. hsa_circ_0023305 hsa_circ_CCND1 circ_0023305 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "In summary, these data propose a new mechanism by which the hsa_circ_0023305/miR-218-5p/TRPM7 network enhances LSCC progression." 2 Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway. - hsa_circ_RAB31 circRAB31 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Our results demonstrated that circRAB31 could serve as a sponge of miR-885-5p to regulate gastric cancer cell proliferation, migration, and invasion by affecting the PTEN/PI3K/AKT signaling." 1 circATP2A2 promotes osteosarcoma progression by upregulating MYH9. - hsa_circ_ATP2A2 circATP2A2 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circATP2A2 accelerated OS cell malignancy and glycolysis through upregulating MYH9 via sponging miR-335-5p, offering a promising target for OS treatment." 2 "Combined effect of unfolded protein response and circZc3h4, circRNA Scar in mouse ovary and uterus damage induced by procymidone." - mmu_circ_Zc3h4 circZc3h4 DOID:1100 ovarian disease ovary and uterus damage RT-qPCR down-regulated It is speculated that UPR may antagonize the partial ovarian and uterine damage in adolescent mice induced by PCM at doses less than NOAEL via changes in circZc3h4 and circRNA Scar. 1 Downregulation of Circular RNA PSEN1 ameliorates ferroptosis of the high glucose treated retinal pigment epithelial cells via miR-200b-3p/cofilin-2 axis. - hsa_circ_PSEN1 circ-PSEN1 DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR up-regulated knockdown of circ-PSEN1 can mitigate ferroptosis of ARPE19 cells induced by HG via the miR-200b-3p/CFL2 axis. 1 CircFOXM1 promotes proliferation and metastasis of hepatocellular carcinoma via regulating miR-1179/SPAG5 axis. - hsa_circ_FOXM1 CircFOXM1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated CircFOXM1 promoted HCC cell proliferation and metastasis by regulating miR-1179/SPAG5 axis. 2 Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating the miR-564/ZIC2 axis. - hsa_circ_DPP4 circDPP4 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Blocking circDPP4 antagonizes cell progression of PC and contributes to in vitro DTX cytotoxicity via regulating the miR-564/ZIC2 axis, at least. The present study suggests that circDPP4 is a potential biomarker and target for PC." 3 Serum hsa_circ_0087776 as a new oncologic marker for the joint diagnosis of multiple myeloma. hsa_circ_0087776 hsa_circ_TMEFF1 circ_0087776 DOID:9538 multiple myeloma multiple myeloma RT-qPCR down-regulated These studies suggest that hsa_circ_0087776 can be used as a new oncology marker for the combined diagnosis of MM. 1 Hsa_circ_0008259 modulates miR-21-5p and PDCD4 expression to restrain osteosarcoma progression. hsa_circ_0008259 hsa_circ_LMO7 circ_0008259 DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated Circ_0008259 suppresses OS progression via regulating miR-21-5p/PDCD4 axis. 1 CircSEC24A upregulates TGFBR2 expression to accelerate pancreatic cancer proliferation and migration via sponging to miR-606. - hsa_circ_SEC24A CircSEC24A DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "These findings indicated that the progression of pancreatic cancer can be driven by circSEC24A influencing miR-606/TGFBR2 axis. Therefore, circSEC24A might be used as a critical biomarker influencing the early diagnosis and prognosis of pancreatic cancer." 1 Circ_0007919 exerts an anti-tumor role in colorectal cancer through targeting miR-942-5p/TET1 axis. hsa_circ_0007919 - Circ_0007919 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated circ_0007919 inhibits CRC cell growth and migration via regulating the miR-942-5p/TET1 axis. This study helps to better understand the molecular mechanism of CRC progression. 1 Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation. - hsa_circ_Esyt2 circEsyt2 DOID:178 vascular disease vascular remodeling RT-qPCR up-regulated "we identified a potentially novel circRNA that regulated vascular remodeling, via altered RNA splicing, in atherosclerotic mouse models." 1 The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p. - hsa_circ_DLG1 circDLG1 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Overall, our findings demonstrate how circDLG1 promotes gastric cancer cell proliferation, migration, invasion and immune evasion and provide a new perspective on the role of circRNAs during gastric cancer progression." 1 Differential expression of circular RNA in patients with white matter hyperintensity and cognitive impairment. - - cricRNAs DOID:1561 cognitive disorder cognitive impairment microarray dysregulated "The circRNA expression profile of patients with WMH is changed significantly. The differentially expressed circRNA may be the cause of WMH; Hsa_circ_0092222, hsa_circ_0000662, and hsa_circ_0083773 may regulate the expression of target genes by targeting adsorption of the target miRNA, leading to brain white matter damage through Janus kinase 2 (JAK2)/signal transducers and activators of transcription (STAT3) signal pathway and Wnt signal pathway.There is no significant difference in circRNA expression profile between WMH with or without cognitive impairment. Cognitive impairment in patients with WMH may have other reasons." 1 Hsa_Circ_0001860 Promotes Smad7 to Enhance MPA Resistance in Endometrial Cancer via miR-520h. hsa_circ_0001860 hsa_circ_ZCCHC7 Circ_0001860 DOID:1380 endometrial cancer endometrial cancer RT-qPCR down-regulated "Hsa_circ_0001860 plays an important role in the development of MPA resistance in EC through miR-520h/Smad7 axis, and it could be targeted to reverse the MPA resistance in endometrial cancer." 1 CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma. - hsa_circ_LRRC7 CircularLRRC7 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated "In summary, circLRRC7 may be a tumor suppressor that associated with miR-1281 and PDXP expression in GBM, which may provide novel therapeutic targets for GBM treatment." 1 Hsa_circ_0003204 Knockdown Weakens Ox-LDL-Induced Cell Injury by Regulating miR-188-3p/TRPC6 Axis in Human Carotid Artery Endothelial Cells and THP-1 Cells. hsa_circ_0003204 hsa_circ_USP36 circ_0003204 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Circ_0003204 knockdown mitigated ox-LDL-induced injury in HCtAECs and THP-1 cells via regulating the miR-188-3p/TRPC6 axis, indicating that circ_0003204 might play an important role in carotid artery AS." 7 CircRNA_0044556 diminishes the sensitivity of triple_negative breast cancer cells to adriamycin by sponging miR_145 and regulating NRAS. hsa_circ_0044556 - CircRNA_0044556 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "CircRNA_0044556 was negatively correlated with miR_145 yet positively correlated with NRAS, the target gene of miR_145, in addition to the discovery suggesting the negative regulatory effects of circRNA_0044556 on miR_145. CircRNA_0044556 diminished the sensitivity of TNBC cells to ADM via the miR_145/NRAS axis." 1 Circular RNA circ_0040823 inhibits the proliferation of acute myeloid leukemia cells and induces apoptosis by regulating miR-516b/PTEN. hsa_circ_0040823 - circ_0040823 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR down-regulated "This study showed that circ_0040823 inhibited proliferation and induced apoptosis of AML cells by sponging miR-516b, thereby diminishing the regulatory effect of miR-516b on PTEN. These findings identified circ_0040823/miR-516b/PTEN as a new therapeutic target for AML." 1 Circular RNA circFADS2 inhibits the progression of cutaneous squamous cell carcinoma by regulating miR-766-3p/HOXA9 axis. - hsa_circ_FADS2 circFADS2 DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma RT-qPCR down-regulated "CircFADS2 suppressed CSCC progression by regulating miR-766-3p/HOXA9 axis, which might provide a promising therapeutic target for CSCC." 3 CircRNAPTK2 Promotes Cardiomyocyte Apoptosis in Septic Mice by Competitively Binding to miR-29b-3p with BAK1. - mmu_circ_PTK2 circPTK2 DOID:0040085 bacterial sepsis Sepsis RT-qPCR up-regulated "CircPTK2 competitively bound to miR-29b-3p to upregulate BAK1 mRNA level, to promote cardiomyocyte apoptosis, inflammatory response, and myocardial damage of the myocardium of septic mice." 1 Activation of YAP1 by N6-Methyladenosine-Modified circCPSF6 Drives Malignancy in Hepatocellular Carcinoma. - hsa_circ_CPSF6 circCPSF6 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated These findings offer novel insights into the regulation of circRNAs by m6A modifications and the role of this epigenetic reprogramming in HCC. 2 Circular RNA mmu_circ_0001598 Contributes to IL-1beta-Induced Osteoarthritis Progression by Regulating miR-127-3p. mmu_circ_0001598 mmu_circ_Rsf1 circ_0001598 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Taken together, our results demonstrate the fundamental role of circ_0001598 and provide new ideas for the prevention and treatment of osteoarthritis." 1 "CircGOT1 promotes cell proliferation, mobility, and glycolysis-mediated cisplatin resistance via inhibiting its host gene GOT1 in esophageal squamous cell cancer." - hsa_circ_GOT1 CircGOT1 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated Our results indicate the oncogene role of circGOT1 in ESCC via an endogenous competition RNA (ceRNA) mechanism to promote GOT1 expression via sponging miR-606. 1 Circ_0014235 confers Gefitinib resistance and malignant behaviors in non-small cell lung cancer resistant to Gefitinib by governing the miR-146b-5p/YAP/PD-L1 pathway. hsa_circ_0014235 - Circ_0014235 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0014235 confers Gefitinib resistance and malignant behaviors in Gefitinib-resistant NSCLC by governing the miR-146b-5p/YAP/PD-L1 pathway. 2 Circular RNA circ_0000644 promotes papillary thyroid cancer progression via sponging miR-1205 and regulating E2F3 expression. hsa_circ_0000644 - Circ_0000644 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated Circ_0000644 up-regulates E2F3 expression via sponging miR-1205 to promote PTC progression. 1 Circ_LPAR3 promotes the progression of oral squamous cell carcinoma (OSCC). - hsa_circ_LPAR3 Circ_LPAR3 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated Knockdown of circ_LPAR3 could inhibit the OSCC progression by sponging miR-513b-5p and activating VEGFC and AKT1. 3 circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis. hsa_circ_0020303 hsa_circ_CHST15 circCHST15 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, microarray" up-regulated We found that sponging of miR-125a-5p to promote EIF4EBP1 expression is the underlying mechanism of hsa_circ_0020303-induced ccRCC progression. This prompts further investigation of circCHST15 as a potential prognostic biomarker and therapeutic target for ccRCC. 1 CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer. - hsa_circ_IL4R CircIL4R DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Our findings demonstrate that upregulation of circIL4R plays an oncogenic role in CRC progression and may serve as a promising diagnostic and prognostic biomarker for CRC detection and as a potential therapeutic target for CRC treatment. 1 CircCDK1 knockdown reduces CDK1 expression by targeting miR-489-3p to suppress the development of breast cancer and strengthen the sensitivity of Tamoxifen. - hsa_circ_CDK1 CircCDK1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated CircCDK1 knockdown enhanced the sensitivity of Tamoxifen in breast cancer cells and suppressed cell growth and survival by depleting CDK1 expression via releasing miR- 489-3p. 1 CircLDLR Promotes Papillary Thyroid Carcinoma Tumorigenicity by Regulating miR-637/LMO4 Axis. - hsa_circ_LDLR CircLDLR DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "Taken together, these results demonstrated that circLDLR promoted PTC tumorigenesis through miR-637/LMO4 axis, which may provide a novel insight into the understanding of PTC tumorigenesis and be useful in developing potential targets for PTC treatment." 3 ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in Bladder Cancer via Targeting miR-3666. - hsa_circ_RHOT1 circRHOT1 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated These results may provide a new direction for developing novel diagnostic or therapeutic targets for BC. 1 Circular RNA Pvt1 oncogene (CircPVT1) promotes the progression of papillary thyroid carcinoma by activating the Wnt/beta-catenin signaling pathway and modulating the ratio of microRNA-195 (miR-195) to vascular endothelial growth factor A (VEGFA) expression. - hsa_circ_PVT1 CircPVT1 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "CircPVT1_ould serve as a molecule sponge for_iR-195_nd mediate the ceRNA network to promote the expression of_EGFA, thus contributed to the malignant progression of PTC." 2 CircRNA_001895 promotes sunitinib resistance of renal cell carcinoma through regulation of apoptosis and DNA damage repair. - - CircRNA_001895 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "In conclusion, circRNA_001895 was implicated in the sunitinib resistance in RCC through regulation of apoptosis and DNA damage repair, suggesting that circRNA_001895 might be a potential therapeutic target for advanced RCC." 1 Genome-wide circular RNA (circRNA) and mRNA profiling identify a circMET-miR-410-3p regulatory motif for cell growth in colorectal cancer. - hsa_circ_MET circMET DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "In conclusion, our work identifies a novel regulatory role of circMET and provides a potential diagnostic biomarker for CRC." 1 Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner. hsa_circ_0003074 - circ_0003074 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Rg3 inhibited OS progression through circ_0003074/miR-516b-5p/KPNA4 axis, showing the potential of Rg3 as a therapeutic agent for OS." 1 "Down-regulation of circ_0058058 suppresses proliferation, angiogenesis and metastasis in multiple myeloma through miR-338-3p/ATG14 pathway." hsa_circ_0058058 - circ_0058058 DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated "Circ_0058058 functions as a sponge for miR-338-3p to elevate ATG14 expression to promote MM cell proliferation, metastasis and angiogenesis, affording a potential therapeutic target for MM prevention." 2 CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/beta-catenin signaling pathway and epithelial-to-mesenchymal transition. - hsa_circ_MTO1 CircMTO1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "These findings indicated that circMTO1 suppressed HCC progression via the circMTO1/ miR-541-5p/ZIC1 axis by regulating Wnt/beta-catenin signaling and epithelial-to-mesenchymal transition, making it a novel therapeutic target." 3 "Hsa_circ_0076931 suppresses malignant biological properties, down-regulates miR-6760-3p through direct binding, and up-regulates CCBE1 in glioma." hsa_circ_0076931 hsa_circ_BAI3 circ_0076931 DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" up-regulated The expression of miR-6760-3p and CCBE1 in hsa_circ_0076931-overexpressed tumors of BALB/C nude mice and glioma tissues and relevance to prognosis. 1 Knockdown of circular RNA hsa_circ_0062270 suppresses the progression of melanoma via downregulation of CDC45. hsa_circ_0062270 hsa_circ_CDC45 - DOID:1909 melanoma melanoma RT-qPCR up-regulated Downregulation of hsa_circ_0062270 can inhibit the progression of melanoma through downregulation of CDC45. 2 CircARHGAP12 Triggers Mesenchymal Stromal Cell Autophagy to Facilitate its Effect on Repairing Diabetic Wounds by Sponging miR-301b-3p/ATG16L1 and miR-301b-3p/ULK2. - hsa_circ_ARHGAP12 CircARHGAP12 DOID:9351 diabetes mellitus diabetic wound "RT-qPCR, RNA-seq" down-regulated hese results suggest that circARHGAP12/miR-301b-3p/ATG16L1 and circARHGAP12/miR-301b-3p/ULK2 regulatory networks might be an underlying therapeutic target for MSCs in diabetic wound healing. 1 Circular RNA circPPP6R3 upregulates CD44 to promote the progression of clear cell renal cell carcinoma via sponging miR-1238-3p. - hsa_circ_PPP6R3 circPPP6R3 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, RNA-seq" up-regulated Our study thus provided evidence that the regulatory network involving circPPP6R3/miR-1238-3p/CD44 axis might provide promising biomarkers as well as a therapeutic approach for ccRCC. 1 Placental transcriptome sequencing combined with bioinformatics predicts potential genes and circular RNAs associated with hemoglobin Bart hydrops fetalis syndrome. hsa_circ_0003961 hsa_circ_PPHLN1 - DOID:178 vascular disease hemoglobin Bart hydrops fetalis syndrome "RT-qPCR, RNA-seq" up-regulated Our study characterized the placental transcriptome of BHFS. The circRNAs hsa_circ_0003961 and hsa_circ_0006687 in placenta may be relevant to BHFS. 2 Placental transcriptome sequencing combined with bioinformatics predicts potential genes and circular RNAs associated with hemoglobin Bart hydrops fetalis syndrome. hsa_circ_0003961 hsa_circ_PPHLN1 - DOID:178 vascular disease hemoglobin Bart hydrops fetalis syndrome "RT-qPCR, RNA-seq" up-regulated Our study characterized the placental transcriptome of BHFS. The circRNAs hsa_circ_0003961 and hsa_circ_0006687 in placenta may be relevant to BHFS. 2 circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway. hsa_circ_0094343 hsa_circ_PTEN circPTEN DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "To conclude, circPTEN suppresses CRC progression via regulation of PTEN/AKT pathway." 2 circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis. hsa_circ_0002109 - circRNA-0002109 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Our results indicate that circRNA-0002109 plays an important role in the proliferation, invasion, and migration of glioma cells by regulating the miR-129-5P/EMP2 axis, which provides a new potential therapeutic target for glioma." 1 Circular RNA_0001073 (circ_0001073) Suppresses The Progression of Non-Small Cell Lung Cancer via miR-582-3p/RGMB Axis. hsa_circ_0001073 hsa_circ_ACVR2A circ_0001073 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" down-regulated "Circ_0001073_p-regulates_GMB_xpression through adsorbing_iR-582-3p_o inhibit NSCLC progression, suggesting its potential as a novel therapeutic target in NSCLC." 1 hsa_circ_0001275 Is One of a Number of circRNAs Dysregulated in Enzalutamide Resistant Prostate Cancer and Confers Enzalutamide Resistance In Vitro. hsa_circ_0001275 hsa_circ_PLCL2 circ_0001275 DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" up-regulated "Our data suggest that increased levels of hsa_circ_0001275 contribute to enzalutamide resistance. hsa_circ_0001275 plasma expression showed a trend that mirrors the PSA level at specific disease time points, indicating that circRNAs mirror disease recurrence and burden and may be associated with enzalutamide resistance." 1 New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer. hsa_circ_0001445 hsa_circ_SMARcA circSMARcA5 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated A prognostic significance of hsa_circ_0001445 for patients with metastatic CRC was established. 1 A Novel Circular RNA CircRFX3 Serves as a Sponge for MicroRNA-587 in Promoting Glioblastoma Progression via Regulating PDIA3. - hsa_circ_RFX3 CircRFX3 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated circRFX3 could act as a cancer-promoting circRNA to boost the development of GBM and regulate the miR-587/PDIA3/beta-catenin axis. 1 Depleting circ_0088364 restrained cell growth and motility of human hepatocellular carcinoma via circ_0088364-miR-1270-COL4A1 ceRNA pathway. hsa_circ_0088364 hsa_circ_MRRF circ_0088364 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "In conclusion, circ_0088364 was oncogenic in human HCC, and blocking circ_0088364 could suppress HCC cell growth and motility via regulating miR-1270-COL4A1 interaction. This finding contributed to the understanding of carcinogenic mechanism of circ_0088364 in HCC, and circ_0088364-miR-1270-COL4A1 ceRNA pathway might be a potential therapeutic target to interfere the progression of HCC." 2 Analysis and validation of m6A regulatory network: a novel circBACH2/has-miR-944/HNRNPC axis in breast cancer progression. - hsa_circ_BACH2 circBACH2 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Our findings decipher a novel circRNA-based m6A regulatory mechanism involved in BC progression, thus providing attractive diagnostic and therapeutic strategies for combating BC." 1 Hsa_circ_0000437 upregulates and promotes disease progression in rheumatic valvular heart disease. hsa_circ_0000437 hsa_circ_CORO1C circ_0000437 DOID:50827 rheumatic heart disease rheumatic valvular heart disease RT-qPCR up-regulated Has_circ_0000437 can promote the process of RVHD and may be a potential for the diagnosis and treatment of RVHD. 1 Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N(6)-methyladenosine-dependent manner in atopic dermatitis and psoriasis. hsa_circ_0004287 hsa_circ_MALAT1 circ_0004287 DOID:3310 atopic dermatitis atopic dermatitis RT-qPCR up-regulated "hsa_circ_0004287 inhibits M1 macrophage activation in an m6A-dependent manner in AD and psoriasis, and may serve as a general therapeutic candidate for AD and psoriasis." 1 Circular RNA circ_0002984 Promotes Cell Proliferation and Migration by Regulating miR-181b-5p/Vascular Endothelial Growth Factor Axis and PI3K-AKT Signaling Pathway in Oxidized Low-Density Lipoprotein-Treated Vascular Smooth Muscle Cells. hsa_circ_0002984 - circ_0002984 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Circ_0002984 downregulation suppressed cell proliferation and migration by regulating miR-181b-5p/VEGFA axis and phosphatidylinositol 3 kinase-AKT pathway in ox-LDL-stimulated VEGFA, providing a new mechanism for AS pathogenesis." 1 Integral Analyses of Competing Endogenous RNA Mechanisms and DNA Methylation Reveal Regulatory Mechanisms in Osteosarcoma. hsa_circ_0001753 hsa_circ_CREB3L2 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "Methylated DEGs may be involved in the development of OS, and the hsa_circ_0001753/has_miR_760/CD74 network may serve as a target for the early diagnosis of and targeted therapy for OS." 1 Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis. hsa_circ_0062682 hsa_circ_TPST2 circ_0062682 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "these data demonstrate, for the first time, that circ_0062682 promotes serine metabolism and tumor growth in CRC by regulating the miR-940/PHGDH axis, suggesting circ_0062682 as a potential novel therapeutic target for CRC." 1 Circ_0000745 promotes acute lymphoblastic leukemia progression through mediating miR-494-3p/NET1 axis. hsa_circ_0000745 - Circ_0000745 DOID:9952 acute lymphoblastic leukemia acute lymphoblastic leukemia RT-qPCR up-regulated Circ_0000745 contributed to ALL development partly by binding to miR-494-3p to induce NET1 expression.0020. 2 Circ-MKLN1/miR-377-3p/CTGF Axis Regulates the TGF-beta2-induced Posterior Capsular Opacification in SRA01/04 Cells. - hsa_circ_MKLN1 Circ-MKLN1 DOID:0070353 cataract posterior capsule opacification RT-qPCR up-regulated These results showed that circ-MKLN1 contributed to the progression of PCO_n vitro_y increasing the CTGF expression via sponging miR-377-3p. Circ-MKLN1 might be important for improving the molecular target therapy in PCO. 1 Circ_0000527 Drives Retinoblastoma Progression by Regulating miR-1236-3p/SMAD2 Pathway. hsa_circ_0000527 - Circ_0000527 DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated Circ_0000527/miR-1236-3p/SMAD2 axis played a positive role in the progression of RB. 5 EIF4A3-Induced circARHGAP29 Promotes Aerobic Glycolysis in Docetaxel-Resistant Prostate Cancer through IGF2BP2/c-Myc/LDHA Signaling. - hsa_circ_ARHGAP29 circARHGAP29 DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" up-regulated "Upregulation of a novel circRNA, circARHGAP29, promotes docetaxel resistance and glycolytic metabolism, suggesting it could be a prognostic biomarker and therapeutic target in chemoresistant prostate cancer." 1 Circular RNA CircPVT1 Inhibits 5-Fluorouracil Chemosensitivity by Regulating Ferroptosis Through MiR-30a-5p/FZD3 Axis in Esophageal Cancer Cells. - hsa_circ_PVT1 CircPVT1 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "These results suggested a key role for circPVT1 in ESCC 5-FU-chemosensitivity in regulating the Wnt/beta-catenin pathway and ferroptosis_ia_iR-30a-5p/FZD3 axis, which might be a potential target in ESCC therapy." 1 Circ_0005320 promotes oral squamous cell carcinoma tumorigenesis by sponging microRNA-486-3p and microRNA-637. hsa_circ_0005320 - Circ_0005320 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "This study revealed a novel regulatory network of circ_0005320-miR-486-3p/miR-637 axis in OSCC progression, suggesting that circ_0005320 might be a potential biomarker and therapeutic target for OSCC." 1 Knockdown hsa_circ_0063526 inhibits endometriosis progression via regulating the miR-141-5p / EMT axis and downregulating estrogen receptors. hsa_circ_0063526 hsa_circ_RANGAP1 circ_0063526 DOID:288 endometriosis of uterus endometriosis RT-qPCR up-regulated Our data suggest that hsa_circ_0063526 and miR-141-5p are possible biomarkers and therapeutic targets for endometriosis. 1 Circ_0000620 acts as an oncogenic factor in gastric cancer through regulating MMP2 expression via sponging miR-671-5p. hsa_circ_0000620 - Circ_0000620 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_0000620 knockdown inhibited the malignant development of GC partly through modulating the miR-671-5p/MMP2 axis. 1 CircPOSTN competes with KIF1B for miR-185-5p binding sites to promote the tumorigenesis of glioma. - hsa_circ_POSTN CircPOSTN DOID:0060108 brain glioma glioma RT-qPCR up-regulated "CircPOSTN acted as an oncogene to expedite glioma tumorigenesis via targeting miR-185-5p/KIF1B axis, indicating a potential therapeutic target for glioma." 5 Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27. hsa_circ_0091579 - Circ_0091579 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ_0091579 exhibited an oncogenic role to enhance the malignant potential of HCC cells through mediating miR-136-5p/TRIM27 axis in vitro and in vivo. 6 CircRTN4IP1 regulates the malignant progression of intrahepatic cholangiocarcinoma by sponging miR-541-5p to induce HIF1A production. - hsa_circ_RTN4IP1 CircRTN4IP1 DOID:4928 intrahepatic cholangiocarcinoma intrahepatic cholangiocarcinoma RT-qPCR up-regulated "CircRTN4IP1 knockdown inhibited ICC cell malignancy by miR-541-5p/HIF1A axis, providing us with a reliable target for the therapy of ICC." 1 "Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance." - hsa_circ_PTK2 circPTK2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circPTK2 interference suppressed CRC proliferation, migration, invasion and chemoresistance via regulating miR-136-5p and YTHDF1." 4 Downregulation of hsa_circRNA_0001400 Helps to Promote Cell Apoptosis Through Disruption of the circRNA_0001400-miR-326 Sponge in Cervical Cancer Cells. hsa_circ_0001400 - circRNA_0001400 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In conclusion, this study provides evidence that the hsa_circRNA_0001400-miR-326-Akt network promotes cervical cancer progression. Notably, our findings demonstrate the novel antitumor effects of hsa_circRNA_0001400_siRNA in cervical cancer." 1 Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus-related liver cancer cells. hsa_circ_0066966 hsa_circ_GOLGB1 circ_0066966 DOID:3571 liver cancer liver cancer "RT-qPCR, microarray" up-regulated "in the present study, comprehensive circRNA profiling in HBV-positive liver cancer cells indicated that hsa_circ_0066966 may regulate the progression of HBV-positive liver cancer." 1 Hsa_circ_0074298 promotes pancreatic cancer progression and resistance to gemcitabine by sponging miR-519 to target SMOC. hsa_circ_0074298 hsa_circ_HARS circ_0074298 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "By sponging miR-519 and targeting SMOC2, hsa_circ_0074298 promotes the growth and metastasis of pancreatic cancer and increases the resistance of pancreatic cancer cells to gemcitabine." 1 hsa_circ_0005358 suppresses cervical cancer metastasis by interacting with PTBP1 protein to destabilize CDCP1 mRNA. hsa_circ_0005358 hsa_circ_Gli1 circ_0005358 DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated "Our findings reveal the function of hsa_circ_0005358 in tumor metastasis, which may be applied to a potential therapeutic approach for patients with metastatic cervical cancer." 1 Hsa_circ_0000652 Aggravates Inflammation by Activation of Macrophages and Enhancement of OX40/OX40L Interaction in Ankylosing Spondylitis. hsa_circ_0000652 hsa_circ_IQGAP1 circ_0000652 DOID:7147 ankylosing spondylitis ankylosing spondylitis "RT-qPCR, RNA-seq" up-regulated hsa_circ_0000652 was upregulated in AS patients and may serve as a pro-inflammatory factor in macrophages and a positive regulator of OX40/OX40L by sponging hsa-miR-1179. 1 "CircPAPPA Regulates the Proliferation, Migration, Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through the miR-3127-5p/HOXA7 Axis." - hsa_circ_CCDC66 CircPAPPA DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "Our research indicated that circPAPPA positively regulated the biological function of trophoblast cells to mediate the progression of PE by miR-3127-5p/HOXA7 axis, which suggested that circPAPPA might be a potential biomarker for PE." 1 Circ_0001665 Contributes to the Occurrence of Vestibular Schwannoma via Targeting miR-302a-3p/Adam9/EGFR Signaling Pathway. hsa_circ_0001665 - Circ_0001665 DOID:3192 neurilemmoma vestibular schwannoma RT-qPCR up-regulated our study identified a novel perspective for exploration into molecular mechanisms in VS. 1 Circular RNA CCDC66 Regulates Osteoarthritis Progression by Targeting miR-3622b-5p. - hsa_circ_CCDC66 CircCCDC66 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated CircCCDC66 promoted OA chondrocyte apoptosis by regulating the miR-3622b-5p/SIRT3 axis.. 1 Plasma circN4BP2L2 is a promising novel diagnostic biomarker for epithelial ovarian cancer. - hsa_circ_N4BP2L2 circN4BP2L2 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "Plasma circN4BP2L2 is significantly downregulated in EOC and might serve as a promising novel diagnostic biomarker for EOC patients, especially in early stage EOC cases.." 1 circCDYL2 promotes trastuzumab resistance via sustaining HER2 downstream signaling in breast cancer. - hsa_circ_CDYL2 circCDYL2 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circCDYL2-GRB7-FAK complex plays a critical role in maintaining HER2 signaling, which contributes to trastuzumab resistance and circCDYL2 is a potential biomarker for trastuzumab-resistance in HER2+_C patients." 1 Circulating exosomal hsa_circRNA_0039480 is highly expressed in gestational diabetes mellitus and may be served as a biomarker for early diagnosis of GDM. hsa_circ_0039480 hsa_circ_NUP93 hsa_circRNA_0039480 DOID:11714 gestational diabetes gestational diabetes mellitus RT-qPCR up-regulated Plasma exosomal hsa_cirRNA_0039480 is highly expressed in GDM patients at different stages and may be served as a candidate biomarker for early detection of GDM. 1 CircRNF121 knockdown suppresses the progression of cervical cancer by regulating miR-153-3p/ATF2 axis and wnt/beta-catenin pathway. - hsa_circ_RNF121 CircRNF121 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circRNF121 exerted the tumor-suppressive role in CC progression by altering miR-153-3p/ATF2 axis. These results suggested that circRNF121 might be a possible circ-targeted therapy for patients with CC. 3 Circular RNA circ-LARP1B contributes to cutaneous squamous cell carcinoma progression by targeting microRNA-515-5p/TPX2 microtubule nucleation factor axis. - hsa_circ_LARP1B circ-LARP1B DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma RT-qPCR up-regulated circ-LARP1B contributed to CSCC progression by targeting miR-515-5p/TPX2 axis. The circ-LARP1B/miR-515-5p/TPX2 axis might provide novel therapeutic targets for CSCC patients. 5 Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281. hsa_circ_0001588 hsa_circ_ERBB4 Circ_0001588 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Circ_0001588 acted as an oncogene in glioma malignant progression by miR-1281/ERBB4 pathway, suggesting the potential of circ_0001588 as a therapeutic target for glioma." 1 Identifying a novel IRF3/circUHRF1/miR-1306-5p/ARL4C axis in pancreatic ductal adenocarcinoma progression. - hsa_circ_UHRF1 circUHRF1 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated Our results suggest that circUHRF1 is one promising diagnosis or therapeutic target for PDAC management. 1 CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNA-lncRNA pathway and stabilizing epithelial-mesenchymal transition protein. - hsa_circ_RTN4 CircRTN4 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "The upregulated circRTN4 promotes tumor growth and liver metastasis in PDAC through the novel circRTN4-miR-497-5p-HOTTIP pathway. Also, circRTN4 stabilizes RAB11FIP1 to contribute EMT." 1 Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network. hsa_circ_0078607 - Circ_0078607 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "Circ_0078607 could serve as a sponge of miR-32-5p to regulate SIK1 expression, thereby inhibiting OC progression." 4 Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression. - hsa_circ_CCDC85A circCCDC85A DOID:1612 breast cancer breast cancer RT-qPCR down-regulated Our findings provide novel evidence that circCCDC85A inhibits the progression of breast cancer by functioning as a molecular sponge of miR-550a-5p to enhance MOB1A expression. 1 Circular BANP knockdown inhibits the malignant progression of residual hepatocellular carcinoma after insufficient radiofrequency ablation. - hsa_circ_BANP circ-BANP DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Knockdown of circ-BANP upregulated let-7f-5p to inhibit proliferation, migration, and EMT formation in residual HCC remaining after insufficient RFA. Effects occur via regulation of the TLR4/STAT3 signaling pathway." 2 Circ_0026134 promotes NSCLC progression by the miR-3619-5p/CHAF1B axis. hsa_circ_0026134 - Circ_0026134 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our study identified a novel regulatory mechanism, the circ_0026134/miR-3619-5p/CHAF1B axis, for the oncogenic role of circ_0026134 in NSCLC, highlighting circ_00261345 inhibition as a potential therapeutic method against NSCLC." 3 Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p. hsa_circ_0003258 hsa_circ_ZNF652 circ_0003258 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated Upregulation of hsa_circ_0003258 drives tumor progression through both hsa_circ_0003258/miR-653-5p/ARHGAP5 axis and hsa_circ_0003258/IGF2BP3 /HDAC4 axis. Hsa_circ_0003258 may act as a promising biomarker for metastasis of PCa and an attractive target for PCa intervention. 1 CircRNA-ABCB10 promotes gastric cancer progression by sponging miR-1915-3p to upregulate RaC1. - hsa_circ_ABCB10 CircRNA-ABCB10 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our study revealed that circ-ABCB10 promoted GC progression via targeting the miR-1915-3p/Rac1 axis, and circ-ABCB10 might be a potential target for GC diagnosis and treatment." 1 Systematic Analysis of mRNAs and ncRNAs in BMSCs of Senile Osteoporosis Patients. - - circRNA008876 DOID:11476 osteoporosis senile osteoporosis "RT-qPCR, RNA-seq" down-regulated "circRNA008876-miR-150-5p-mRNA could be an important ceRNA network involved in senile osteoporosis, which provides potential biomarkers and therapeutic targets for senile osteoporosis." 1 CircFBXW8 Acts an Oncogenic Role in the Malignant Progression of Non-small Cell Lung Carcinoma by miR-370-3p-Dependent Regulation of TRIM44. - hsa_circ_FBXW8 CircFBXW8 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircFBXW8 modulated NSCLC progression by increasing TRIM44 expression through sponging miR-370-3p, which provided a new direction for studying the therapy of NSCLC." 1 Homo sapiens circular RNA 0003602 (Hsa_circ_0003602) accelerates the tumorigenicity of acute myeloid leukemia by modulating miR-502-5p/IGF1R axis. hsa_circ_0003602 hsa_circ_SMARCC1 - DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "hsa_circ_0003602, miR-502-5p, and IGF1R might form a regulatory axis to affect the carcinogenicity of AML cells and provide potential targets for the treatment of AML." 1 eIF4A3-induced circWAC promotes breast cancer progression through mediating miR-599/E2F3 axis. - hsa_circ_WAC circWAC DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "eIF4A3-induced circWAC promoted the proliferation, migration, invasion, and glycolysis and suppressed the apoptosis of BC cells through mediating miR-599/E2F3 axis, which provided novel potential targets for BC therapy." 1 "Circ_0007385 regulates cell proliferation, apoptosis and stemness via targeting miR-493-3p/RAB22A axis in non-small cell lung cancer." hsa_circ_0007385 - Circ_0007385 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0007385 promoted NSCLC progression by sponging miR-493-3p to increase RAB22A expression, which also offered an underlying targeted therapy for NSCLC treatment." 5 CircRNA ANXA2 Promotes Lung Cancer Proliferation and Metastasis by Upregulating PDPK1 Expression. - hsa_circ_ANXA2 circANXA2 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated circANXA2 regulates the transcription of the miR-33a-5p downstream target gene PDPK1 and affects the malignant progression of lung cancer. 1 Circ_0044516 Enriches the Level of SARM1 as a miR-330-5p Sponge to Regulate Cell Malignant Behaviors and Tumorigenesis of Prostate Cancer. hsa_circ_0044516 - Circ_0044516 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated circ_0044516 deficiency blocked tumor growth in vivo by regulating the miR-330-5p/SARM1 axis. Circ_0044516 as a miR-330-5p sponge increases SARM1 expression. 2 circRNA CRIM1 regulates the migration and invasion of bladder cancer by targeting miR182/Foxo3a axis. - hsa_circ_CRIM1 circRNA-CRIM1 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated circRNA CRIM1 regulated the migration and invasion of bladder cancer by targeting the miR182/Foxo3a axis. 1 A novel circ_MACF1/miR-942-5p/TGFBR2 axis regulates the functional behaviors and drug sensitivity in gefitinib-resistant non-small cell lung cancer cells. - hsa_circ_MACF1 circ_MACF1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated Our findings demonstrated that circ_MACF1 regulated cell functional behaviors and gefitinib sensitivity of A549/GR and PC9/GR cells at least partially by targeting miR-942-5p to induce TGFBR2 expression. 2 Circ_0092291 attenuates angiotensin II-induced cell damages in human aortic vascular smooth muscle cells via mediating the miR-626/COL4A1 signal axis. hsa_circ_0092291 - Circ_0092291 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm RT-qPCR down-regulated "Circ_0092291 might improve the diagnosis and treatment of AAA.Key Points.Biological mechanism, Apoptosis, Molecular target." 1 CircABCC1 promotes the development of glioma by sponging miR-591 and modulating high-mobility group A2. - hsa_circ_ABCC1 CircABCC1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circABCC1 promotes the expression of HMGA2 via sponging of miR-591, thus affecting glioma progression as an important onco-circRNA." 1 Circular RNA Plasmacytoma Variant Translocation 1 (CircPVT1) knockdown ameliorates hypoxia-induced bladder fibrosis by regulating the miR-203/Suppressor of Cytokine Signaling 3 (SOCS3) signaling axis. - hsa_circ_PVT1 circPVT1 DOID:365 bladder disease bladder outlet obstruction "RT-qPCR, microarray" up-regulated circPVT1 regulator of BOO-associated bladder wall remodeling and hypoxia-induced phenotypic changes in BMSCs by targeting the miR-203-SOCS3 signaling axis. 1 "Circ_0017639 facilitates proliferative, migratory, and invasive potential of non-small cell lung cancer (NSCLC) cells via PI3K/AKT signaling pathway." hsa_circ_0017639 hsa_circ_SFMBT2 Circ_0017639 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "We showed that circ_0017639 considerably contributes to the NSCLC development. High circ_0017639 expression was found in NSCLC cells and tissues. It was revealed that an elevated expression of circ_0017639 enhanced the proliferative, migratory, and invasive potential of NSCLC cells through triggering PI3K/AKT signaling cascade, which may provide the experimental evidence for the further targeted intervention therapy of NSCLC." 4 Circ_0003645 serves as miR-335-5p sponge to promote the biological process of diffuse large B-cell lymphoma by upregulating NFIB. hsa_circ_0003645 - Circ_0003645 DOID:0050745 diffuse large B-cell lymphoma large B-cell lymphoma RT-qPCR up-regulated "The present study revealed that circ_0003645 promoted the proliferation and glycolysis of DLBCL cells by the miR-335-5p/NFIB axis, which might provide a novel insight for DLBCL treatment." 1 Hsa_circ_0003288 facilitates tumor progression by targeting miR-145 in non-small cell lung cancer cells. hsa_circ_0003288 hsa_circ_BIRC6 circ_0003288 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Collectively, these findings identified a novel regulatory role of hsa_circ_0003288/miR-145 axis in the progression of NSCLC." 5 Correlation Analysis of circRNA Circ_0071662 in Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma. hsa_circ_0071662 hsa_circ_TPPP Circ_0071662 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR down-regulated Circ_0071662 is lowly expressed in ESCC and may serve as a potential diagnostic and prognostic biomarker for ESCC. 1 CircCCNB1 silencing acting as a miR-106b-5p sponge inhibited GPM6A expression to promote HCC progression by enhancing DYNC1I1 expression and activating the AKT/ERK signaling pathway. hsa_circ_0001495 hsa_circ_CCNB1 CircCCNB1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated We demonstrated that circCCNB1 silencing promoted cell proliferation and metastasis of HCC cells by weakening sponging of oncogenic miR-106b-5p to induce GPM6A underexpression. DYNC1I1 gene expression was up-regulated and further led to activation of the AKT/ERK signaling pathway. 1 CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA. - hsa_circ_CDK14 CircCDK14 DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" up-regulated circCDK14 induces tumor in glioma and increases malignant tumor behavior via the miR-3938/PDGFRA axis.. 1 CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis. - hsa_circ_N4bp1 circN4bp1 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome RT-qPCR up-regulated circN4bp1 can function as a miR-138-5p sponge for the modulation of macrophage polarization through regulation the expression of EZH2 and may serve as a potential target and/or prognostic marker for ARDS patients following sepsis. 1 AhR Antagonist Promotes Differentiation of Papillary Thyroid Cancer via Regulating circSH2B3/miR-4640-5P/IGF2BP2 Axis. - hsa_circ_SH2B3 circSH2B3 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR down-regulated AhR antagonists promote differentiation of PTC via inhibiting the circSH2B3/miR-4640-5p/IGF2BP2 axis. 1 Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease. hsa_circ_0001320 hsa_circ_FOXP1 - DOID:12297 Vogt-Koyanagi-Harada disease Koyanagi-Harada disease "RT-qPCR, RNA-seq" dysregulated Further analysis showed that hsa_circ_0001320 and hsa_circ_0001924 may serve as crucial candidate marker genes of VKH disease. These results reveal that circRNAs may have a crucial immunomodulatory function in the pathophysiological process of VKH disease. 1 Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease. hsa_circ_0001924 hsa_circ_TCONS_00017186 - DOID:12297 Vogt-Koyanagi-Harada disease Koyanagi-Harada disease "RT-qPCR, RNA-seq" dysregulated Further analysis showed that hsa_circ_0001320 and hsa_circ_0001924 may serve as crucial candidate marker genes of VKH disease. These results reveal that circRNAs may have a crucial immunomodulatory function in the pathophysiological process of VKH disease. 1 circITGA7 Acts as a miR-370-3p Sponge to Suppress the Proliferation of Prostate Cancer. - hsa_circ_ITGA7 circITGA7 DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" down-regulated our data indicated that circITGA7 played an important role in inhibiting tumor proliferation in PCa and might be a potential therapeutic target. 1 CircRNA FAT1 Regulates Osteoblastic Differentiation of Periodontal Ligament Stem Cells via miR-4781-3p/SMAD5 Pathway. hsa_circ_0001721 hsa_circ_FAT1 circFAT1 DOID:0080001 bone disease osteogenic differentiation RT-qPCR dysregulated circFAT1 might be considered as a potential target of PDLSCs mediated periodontal bone regeneration. 1 METTL3 Is Suppressed by Circular RNA circMETTL3/miR-34c-3p Signaling and Limits the Tumor Growth and Metastasis in Triple Negative Breast Cancer. - hsa_circ_METTL3 circMETTL3 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "In conclusion, our study demonstrates the functional importance and regulatory mechanism of METTL3 in suppressing the tumor growth of TNBC." 1 CircPIK3C2A Facilitates the Progression of Glioblastoma via Targeting miR-877-5p/FOXM1 Axis. - hsa_circ_PIK3C2A CircPIK3C2A DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "circPIK3C2A functions as ceRNA by mediating miR-877-5p/FOXM1 axis, providing a novel perspective of applying CircPIK3C2A in the clinical intervention of glioblastoma in the future." 1 The circ-PITX1 promotes non-small cell lung cancer development via the miR-30e-5p/ITGA6 axis. - hsa_circ_PITX1 circ-PITX1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ-PITX1 modulates the miR-30e-5p/ITGA6 axis to boost NSCLC progression, hence functioning as an oncogene." 3 Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer. hsa_circ_0000190 hsa_circ_CNIH4 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "hsa_circ_0000190 upregulation can be an effective indicator for the progression of NSCLC, and hsa_circ_0000190 downregulation may possess a potential therapeutic value for the treatment of NSCLC in combination with immunotherapy." 2 "Circ_0020093 Overexpression Alleviates Interleukin-1 Beta-induced Inflammation, Apoptosis and Extracellular Matrix Degradation in Human Chondrocytes by Targeting the miR-181a-5p/ERG Pathway." hsa_circ_0020093 hsa_circ_ATRNL1 Circ_0020093 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "Circ_0020093 overexpression alleviated IL-1beta-induced human chondrocyte inflammatory injury, apoptosis and ECM degradation by targeting miR-181a-5p/ERG pathway." 2 Hsa_circ_0020850 promotes the malignant behaviors of lung adenocarcinoma by regulating miR-326/BECN1 axis. hsa_circ_0020850 hsa_circ_NUP98 circ_0020850 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "Circ_0020850 promoted the malignant development of lung adenocarcinoma by regulating miR-326/BECN1 axis, indicating that circ_0020850 might serve as a promising target for the diagnosis and treatment of lung adenocarcinoma patients." 1 Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3. hsa_circ_0004658 hsa_circ_EMILIN2 circ_0004658 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated These results indicate that exosome circRNAs secreted from RBPJ+/+_¦Ő inhibits tumor progression through the hsa_circ_0004658/miR-499b-5p/JAM3 pathway and hsa_circ_0004658 may be a diagnostic biomarker and potential target for HCC therapy. 1 CircMIIP Contributes to Non-Small Cell Lung Cancer Progression by Binding miR-766-5p to Upregulate FAM83A Expression. - hsa_circ_MIIP CircMIIP DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircMIIP promoted cell proliferation, migration and invasion and suppressed cell apoptosis in NSCLC cells through mediating miR-766-5p/FAM83A axis." 1 Circular RNA circ_0008934 promotes hepatocellular carcinoma growth and metastasis through modulating miR-1305/TMTC3 axis. - hsa_circ_ASAP1 circ_0008934 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Overall, these results demonstrate that downregulation of circ_0008934 repress HCC growth and metastasis by upregulating miR-1305 to inhibit TMTC3, suggesting circ_0008934/ miR-1305/ TMTC3 regulatory axis may be a possible novel therapeutic target for HCC." 3 A Novel Circular RNA CircBRAP May Be Used as an Early Predictor of Preeclampsia and Its Potential Mechanism. - hsa_circ_BRAP CircBRAP DOID:10591 pre-eclampsia Preeclampsia RT-qPCR up-regulated "placenta-derived CircBRAP in plasma may be a novel biomarker for preeclampsia that, together with plasma sFLT1 levels and uterine artery Doppler ultrasound findings, can more effectively predict preeclampsia, and CircBRAP may play a potential role in preeclampsia." 1 Circ_0000647 promotes cell injury by modulating miR-126-5p/TRAF3 axis in oxygen-glucose deprivation and reperfusion-induced SK-N-SH cell model. hsa_circ_0000647 hsa_circ_SEC11A Circ_0000647 DOID:6713 cerebrovascular disease ischemic stroke RT-qPCR up-regulated Circ_0000647 interference relieved OGD/R-induced SK-N-SH cell damage by altering miR-126-5p/TRAF3 axis. 1 CircRNA circTIAM1 promotes papillary thyroid cancer progression through the miR-646/HNRNPA1 signaling pathway. - hsa_circ_TIAM1 circTIAM1 DOID:1781 thyroid gland cancer thyroid cancer "RT-qPCR, RNA-seq" up-regulated Our results reveal an important oncogenic role of circTIAM1 in PTC and may represent a potentially therapeutic target against PTC progression. 1 "Circ_0003221 Downregulation Restrains Cervical Cancer Cell Growth, Metastasis and Angiogenesis by Governing the miR-139-3p/S100A14 Pathway." hsa_circ_0003221 hsa_circ_PTK2 Circ_0003221 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circ_0003221 positively regulated S100A14 expression by targeting miR-139-3p. Circ_0003221 downregulation restrains cervical cancer cell growth, metastasis, and angiogenesis by governing the miR-139-3p/S100A14 pathway." 2 CircRNA casein kinase 1 gamma 1 (circ-CSNK1G1) plays carcinogenic effects in thyroid cancer by acting as miR-149-5p sponge and relieving the suppression of miR-149-5p on mitogen-activated protein kinase 1 (MAPK1). - hsa_circ_CSNK1G1 circ-CSNK1G1 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "Circ-CSNK1G1 acted as miR-149-5p to relieve the inhibition of miR-149-5p on MAPK1, thus promoting the malignant development of thyroid cancer." 1 Circ_0001206 regulates miR-665/CRKL axis to alleviate hypoxia/reoxygenation-induced cardiomyocyte injury in myocardial infarction. hsa_circ_0001206 hsa_circ_CRKL Circ_0001206 DOID:5844 myocardial infarction myocardial Infarction RT-qPCR down-regulated Circ_0001206 regulates miR-665/CRKL axis to alleviate H/R-induced cardiomyocyte injury in MI. Our findings suggest that circ_0001206 might be a potential target for MI treatment. 1 Promotion of tumor progression by exosome transmission of circular RNA circSKA3. hsa_circ_0000467 hsa_circ_SKA3 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Thus, our results showed that the heterogeneously expressed circRNA circSKA3 is complexed with integrin beta1 and TKS5 to form exosomes. circSKA3 can be transmitted via tumor-derived exosomes to potentiate the invasive potential of breast cancer cells expressing lower levels of circSKA3. Transmission of circSKA3 allows for the maintenance of advantageous invasive sub-clones in breast cancer." 2 circRNA circMED27 acts as a prognostic factor and mediator to promote lenvatinib resistance of hepatocellular carcinoma. hsa_circ_0006825 hsa_circ_MED27 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circMED27 acts as a potential therapeutic target for HCC patients receiving lenvatinib therapy and may represent a promising molecular biomarker for forecasting lenvatinib-resistant HCC. 1 Circular RNA CUL2 regulates the development of colorectal cancer by modulating apoptosis and autophagy via miR-208a-3p/PPP6C. - hsa_circ_CUL2 circCUL2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated CircCUL2 participates in progression via the miR-208a-3p/PPP6C axis in colorectal cancer. CircCUL2 would be an underlying target for the diagnosis and therapy of colorectal cancer. 1 Exosomal circRELL1 serves as a miR-637 sponge to modulate gastric cancer progression via regulating autophagy activation. - hsa_circ_RELL1 circRELL1 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Taken together, this study elucidates the suppressive roles of circRELL1/miR-637/EPHB3 axis through autophagy activation in GC progression, inspiring for further understanding of the underlying molecular mechanisms of GC and providing a promising novel diagnostic circulating biomarker and therapeutic target in GC." 1 Exosomal circCARM1 from spheroids reprograms cell metabolism by regulating PFKFB2 in breast cancer. - hsa_circ_CARM1 circCARM1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated BCSC exosome-derived circCARM1 played an important role in breast cancer cell glycolysis by sponging miR-1252-5p which regulated PFKFB2 expression. 1 Hsa_circ_0005729 enhances accuracy in diagnosing parathyroid carcinoma. hsa_circ_0005729 hsa_circ_RNF138 circ_0005729 DOID:1540 parathyroid carcinoma parathyroid carcinoma "RT-qPCR, RNA-seq" up-regulated "The novel circular RNA hsa_circ_0005729 was found to have a higher expression in patients with PC, indicating its usefulness for distinguishing PC from PA." 1 Circular RNA circ_0000515 adsorbs miR-542-3p to accelerate bladder cancer progression via up-regulating ILK expression. hsa_circ_0000515 hsa_circ_RPPH1 circ_0000515 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Circ_0000515, as a tumor promoter, strengthens the viability, migration and aggressiveness of BC cells via modulating miR-542-3p/ILK axis." 2 Circ_SEC61A1 contributes to the progression of multiple myeloma cells via regulating miR-660-5p/CDK6 axis. hsa_circ_0007841 hsa_circ_SEC61A1 - DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated Our study manifested that circ_SEC61A1 could accelerate MM progression at least partially through modulating miR-660-5p/CDK6 axis. 5 Circ_0019693 promotes osteogenic differentiation of bone marrow mesenchymal stem cell and enhances osteogenesis-coupled angiogenesis via regulating microRNA-942-5p-targeted purkinje cell protein 4 in the development of osteoporosis. hsa_circ_0019693 - Circ_0019693 DOID:11476 osteoporosis osteoporosis RT-qPCR down-regulated "circ_0019693 promotes BMSC osteogenic differentiation osteogenesis-coupled angiogenesis via regulating miR-942-5p-targeted PCP4, thus blocking the development of OP." 1 Circular RNA hsa_circ_0032683 inhibits the progression of hepatocellular carcinoma by sponging microRNA-338-5p. hsa_circ_0032683 hsa_circ_NEK9 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Our experiments revealed that hsa_circ_0032683 receded the proliferation ability of HCC via ceRNA (competing endogenous RNAs) mechanism, which provided potential biomarkers and therapeutic targets for HCC patients." 1 Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis. hsa_circ_0001658 hsa_circ_ARID1B - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our research suggests that circ_0001658 acts as a competing endogenous RNA to regulate the viability, autophagy, and apoptosis of GC cells via the miR-182/RAB10 axis. Knockdown of circ_0001658 may be an alternative treatment for GC." 1 Circ_0000658 knockdown inhibits epithelial-mesenchymal transition in bladder cancer via miR-498-induced HMGA2 downregulation. hsa_circ_0000658 hsa_circ_MCTP2 Circ_0000658 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated our study uncovered the tumor-promoting role of circ_0000658 in BCa via the miR-498/HMGA2 axis. 2 EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3. hsa_circ_0001460 hsa_circ_NEIL3 circNEIL3 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "This work reveals that circNEIL3 plays a nonnegligible multifaceted role in promoting gliomagenesis, malignant progression and macrophage tumour-promoting phenotypes polarization, highlighting that circNEIL3 is a potential prognostic biomarker and therapeutic target in glioma." 1 Screening differential circular RNA expression profiles reveals the regulatory role of circMARS in anti-tuberculosis drug-induced liver injury. - hsa_circ_MARS circMARS DOID:399 tuberculosis Tuberculosis "RT-qPCR, microarray" up-regulated "A self-controlled cohort of 35 participants was used to verify the circMARS-miR-6808-5p/-6874-3p/-3157-5p-KMT2C-EGFR function axis. Therefore, circMARS may participate in the compensatory repair mechanism of ADLI through the function axis, and may be a potential biomarker for ADLI diagnosis in TB patients." 1 Knockdown of circ_0007290 alleviates oxygen-glucose deprivation-induced neuronal injury by regulating miR-496/PDCD4 axis. hsa_circ_0007290 - circ_0007290 DOID:3526 cerebral infarction ischemic stroke RT-qPCR up-regulated "Knockdown of circ_0007290 alleviated OGD-induced neuronal injury by regulating miR-496/PDCD4 axis, providing a novel insight into the pathology of ischemic stroke." 1 hsa_circ_0000231 Promotes colorectal cancer cell growth through upregulation of CCND2 by IGF2BP3/miR-375 dual pathway. hsa_circ_0000231 hsa_circ_ARHGAP12 circ_0000231 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "The findings suggested that hsa_circ_0000231 facilitated CRC progression by sponging miR-375 or binding to IGF2BP3 to modulate CCND2, implying that hsa_circ_0000231 might be a potential new diagnostic and therapeutic biomarker of CRC." 2 The novel circ_0084904/miR-802/MAL2 axis promotes the development of cervical cancer. hsa_circ_0084904 hsa_circ_KIAA1429 circ_0084904 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Our study identified circ_0084904 as a novel oncogenic driver in CC depending on the modulation of the miR-802/MAL2 axis, establishing the notion that silencing of circ_0084904 might represent a promising targeted therapy for CC." 2 Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression. - hsa_circ_FAT1 Circ-FAT1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ-FAT1 knockdown repressed FOSL2 expression by sponging miR-619-5p to suppress CRC tumorigenesis, providing a potential approach for CRC therapeutics." 2 Circ_0025039 acts an oncogenic role in the progression of non-small cell lung cancer through miR-636-dependent regulation of CORO1C. hsa_circ_0025039 hsa_circ_FOXM1 Circ_0025039 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0025039 silencing repressed NSCLC malignant progression by reducing CORO1C expression through miR-636, showing the possibility of circ_0025039 as a therapeutic target for NSCLC." 4 The hsa_circRNA_102049 mediates the sorafenib sensitivity of hepatocellular carcinoma cells by regulating Reelin gene expression. - - circRNA_102049 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "These findings support targeting of hsa_circRNA_102049 and RELN in sorafenib-treated HCC cells as a novel intervention, which is expected to overcome sorafenib resistance of HCC cells." 1 Circular RNA circ_0001955 promotes hepatocellular carcinoma tumorigenesis by up-regulating alkaline ceramidase 3 expression through microRNA-655-3p. hsa_circ_0001955 hsa_circ_CSNK1G1 circ_0001955 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated This study suggested a novel circ_0001955/miR-655-3p/ACER3 pathway in HCC progression. 5 circRNA LDLRAD3 Enhances the Malignant Behaviors of NSCLC Cells via the miR-20a-5p-SLC7A5 Axis Activating the mTORC1 Signaling Pathway. - hsa_circ_LDLRAD3 LDLRAD3 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated We concluded that LDLRAD3 exerted oncogenic effects via the miR-20a-5p-SLC7A5 axis to activate the mTORC1 signaling pathway in NSCLC. Our findings enlightened that LDLRAD3 could become a potential therapeutic target in the treatment and management of NSCLC. 1 Circular RNA circSmoc1-2 regulates vascular calcification by acting as a miR-874-3p sponge in vascular smooth muscle cells. - hsa_circ_SMOC1-2 circSmoc1-2 DOID:178 vascular disease vascular calcification RT-qPCR up-regulated "In conclusion, we revealed that the circSmoc1-2/miR-874-3p/Adam19 axis regulates VC, suggesting that circSmoc1-2 may be a novel therapeutic target in the treatment of VC." 1 Circ_0000190 sponges miR-382-5p to suppress cell proliferation and motility and promote cell death by targeting ZNRF3 in gastric cancer. hsa_circ_0000190 hsa_circ_CNIH4 Circ_0000190 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Circ_0000190 suppressed GC progression via miR-382-5p-dependent regulation of ZNRF3. 3 Circ_0006006 facilitates non-small cell lung cancer progression by modulating miR-924/SRSF7 axis. hsa_circ_0006006 hsa_circ_PDK1 Circ_0006006 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0006006 stimulated NSCLC progression by targeting miR-924 to regulate SRSF7 expression. 1 Circ_0044520 regulates the progression of laryngeal squamous cell carcinoma via the miR-338-3p/ROR2 axis. hsa_circ_0044520 hsa_circ_COL1A1 Circ_0044520 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "Circ_0044520 silencing plays anti-proliferation and pro-apoptosis roles in LSCC cells by regulating the miR-338-3p/ROR2 axis, suggesting that the circ_0044520/miR-338-3p/ROR2 axis may be a potential regulatory mechanism for the treatment of LSCC." 3 EIF4A3-induced circCCNB1 (hsa_circ_0001495) promotes glioma progression by elevating CCND1 through interacting miR-516b-5p and HuR. hsa_circ_0001495 hsa_circ_CCNB1 circCCNB1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated circCCNB1 aggravated glioma cell growth by elevating CCND1 through targeting miR-516b-5p and HuR. 1 Exosome-derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironments. - hsa_circ_TRPS1 circTRPS1 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated exosome-derived circTRPS1 from BCa cells can modulate the intracellular reactive oxygen species (ROS) balance and CD8+ T cell exhaustion via the circTRPS1/miR141-3p/GLS1 axis.. 1 Circular RNA circFOXO3 facilitate non-small cell lung cancer progression through upregulating HMGB3 via sponging miR-545-3p/miR-506-3p. - hsa_circ_FOXO3 circFOXO3 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Here, we show thatcircFOXO3 in NSCLC promotes the proliferation, migration and invasion of NSCLC cells, thereby promoting tumor growth. We further find that circFOXO3 sponges miR-545-3p/miR-506-3p that bind to 3-UTR of HMGB3 mRNA, which constitutes the major network fulfilling the circFOXO3s promoting effect. Therefore, we proposed that circFOXO3 could be a potential therapeutic target for NSCLC." 2 CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma. - hsa_circ_NFIB CircNFIB DOID:4928 intrahepatic cholangiocarcinoma intrahepatic cholangiocarcinoma RT-qPCR down-regulated "Our findings identified that cNFIB played a key role in ICC growth and metastasis by regulating MEK1/ERK signaling. Given the efficacy of cNFIB modulation on ICC suppression and trametinib sensitivity, cNFIB appears to be a potential therapeutic molecule for ICC treatment." 1 Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration. hsa_circ_0004354 - Circ_0004354 DOID:90 degenerative disc disease intervertebral disc degeneration RT-qPCR up-regulated "these findings offer a novel insight into the circRNAs-mediated posttranscriptional regulatory network in IVDD, contributing to further clarification of the pathological mechanism of IVDD to develop a promising therapeutic target for IVDD diseases." 1 Competing endogenous RNA network mediated by circ_3205 in SARS-CoV-2 infected cells. - - circ_3205 DOID:0080600 COVID-19 SARS-CoV-2 RT-qPCR up-regulated "We propose that our results convincingly suggest that circ_3205 is a circRNA synthesized by SARS-CoV-2 upon host cell infection and that it may behave as a competitive endogenous RNA (ceRNA), sponging hsa-miR-298 and contributing to the upregulation of KCNMB4 and PRKCE mRNAs." 1 Circ_0000467 Exerts an Oncogenic Role in Colorectal Cancer via miR-330-5p-Dependent Regulation of TYRO3. hsa_circ_0000467 - Circ_0000467 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0000467 knockdown suppressed CRC cell malignant development through modulating the miR-330-5p/TYRO3 network, providing a novel molecular target of CRC therapy." 4 Circular RNA circKIF2A Contributes to the Progression of Neuroblastoma Through Regulating PRPS1 Expression by Sponging miR-377-3p. - hsa_circ_KIF2A circKIF2A DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated "CircKIF2A knockdown impedes cell proliferation, metastasis, and glycolysis partly by regulating the miR-377-3p/PRPS1 axis, suggesting that targeting circKIF2A can be a feasible therapeutic strategy for neuroblastoma." 2 CircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression. hsa_circ_0001795 - CircRNA_0001795 DOID:11476 osteoporosis osteoporosis RT-qPCR down-regulated "Overall, this study uncovered the role of circ_0001795/miR-339-5p/YAP1 axis in regulating osteogenic differentiation, indicating that targeting Circ_0001795 could serve as a novel therapeutic target for OP." 2 Circ_0006220 promotes non-small cell lung cancer progression via sponging miR-203-3p and regulating RGS17 expression. hsa_circ_0006220 hsa_circ_TADA2A Circ_0006220 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0006220 up-regulates RGS17 expression by adsorbing miR-203-3p to promote NSCLC development. 6 CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3. - hsa_circ_MET CircMET DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "CircMET promotes the development of NONO-TFE3 tRCC, and the regulation to both CDKN2A and SMAD3 of circMET was revealed. CircMET has the potential to serve as a novel target for the molecular therapy of NONO-TFE3 tRCC as well as the other cancer with high-expressing circMET." 1 Circ_0007580 knockdown strengthens the radiosensitivity of non-small cell lung cancer via the miR-598-dependent regulation of THBS2. hsa_circ_0007580 - Circ_0007580 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our results revealed that circ_0007580 might be a target for improving the radiosensitivity of NSCLC, which was mainly achieved by regulating the miR-598/THBS2 axis." 1 A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning. - hsa_circ_Homer1 circHomer1 DOID:150 disease of mental health reversal learning RT-qPCR dysregulated "Taken together, our data provide mechanistic insights into the importance of circRNAs in brain function and disease." 1 Lidocaine hampers colorectal cancer process via circITFG2/miR-1204/SOCS2 axis. - hsa_circ_ITFG2 circITFG2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated Lidocaine hindered CRC progression by circITFG2/miR-1204/SOCS2 axis. This finding might beat a path in improving CRC therapy. 1 circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis. - hsa_circ_FARP1 circFARP1 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "The circFARP1/CAV1/miR-660-3p/LIF axis is critical for CAF-induced GEM resistance in PDAC. Hence, circFARP1 may be a potential therapeutic target for PDAC." 1 CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma. - hsa_circ_RPN2 CircRPN2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated The circRNA circRPN2 is a potential prognostic biomarker and therapeutic target in hepatocellular carcinoma that suppresses aerobic glycolysis and metastasis. 1 Circ_0002623 promotes bladder cancer progression by regulating the miR-1276/SMAD2 axis. hsa_circ_0002623 - Circ_0002623 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated circ_0002623 could regulate the expression of TGF-beta and WNT1 via modulating miR-1276 and SMAD2. This study helps to better understand the molecular mechanism underlying BCa progression. 1 CircFAM64A enhances cellular processes in triple-negative breast cancer by targeting the miR-149-5p/CDT1 axis. - hsa_circ_FAM64A CircFAM64A DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Rescue experiments demonstrated that circFAM64A sponged miR-149-5p to increase CDT1 expression, thereby promoting cellular processes in TNBC. Overall, CircFAM64A plays an oncogenic role in TNBC by interacting with miR-149-5p to increase CDT1 expression." 1 Circular RNA SOX5 promotes the proliferation and inhibits the apoptosis of the hepatocellular carcinoma cells by targeting miR-502-5p/synoviolin 1 axis. - hsa_circ_SOX5 circ-SOX5 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "This study demonstrated that the circ-SOX5/miR-502-5p/SYVN1 axis promotes the development of HCC by regulating cell apoptosis. Therefore, circ-SOX5 may be a potential biomarker of HCC." 3 Breviscapine Combined with BMSCs Reduces Abeta Deposition in Rat with Alzheimer Disease by Regulating Circular RNA ciRS-7. - - ciRS-7 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR down-regulated Breviscapine combined with BMSCs treatment can reduce Abeta deposition in AD rats and promote the degradation of APP and BAEC1 by activating NF-kB to promote UCHL1 expression. 1 CircPLK1 Acts as a Carcinogenic Driver to Promote the Development of Malignant Pleural Mesothelioma by Governing the miR-1294/HMGA1 Pathway. - hsa_circ_PLK1 CircPLK1 DOID:7474 malignant pleural mesothelioma malignant pleural mesothelioma RT-qPCR up-regulated "CircPLK1 was overexpressed in exosomes derived from serum of MPM patients. CircPLK1 knockdown inhibited MPM cell proliferation, migration, invasion and stemness by targeting the miR-1294/HMGA1 pathway." 1 Knockdown of circHECTD1 inhibits oxygen-glucose deprivation and reperfusion induced endothelial-mesenchymal transition. - hsa_circ_HECTD1 circHECTD1 DOID:6713 cerebrovascular disease Ischemic stroke RT-qPCR up-regulated "circHECTD1 knockdown significantly alleviated EndoMT process in HCMECs via mediation of miR-335/NOTCH2 axis. Thus, circHECTD1 might act as a potential target against IS." 3 circKCNN2 suppresses the recurrence of hepatocellular carcinoma at least partially via regulating miR-520c-3p/methyl-DNA-binding domain protein 2 axis. - hsa_circ_KCNN2 circKCNN2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated "circKCNN2, transcriptionally repressed by NFYA, suppresses HCC recurrence via the miR-520c-3p/MBD2 axis. Inherent level of circKCNN2 in HCC cells predisposes anti-tumor effect of lenvatinib possibly because both circKCNN2 and lenvatinib repress the expression of FGFR4. circKCNN2 may be a promising predictive biomarker and therapeutic agent for HCC recurrence." 1 Circular RNA circYPEL2: A Novel Biomarker in Cervical Cancer. hsa_circ_0005600 hsa_circ_YPEL2 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "CircYPEL2 exhibited significantly high expression in CC tissue and strong stability in CC cell lines. Furthermore, knockdown and overexpression of circYPEL2 indicated the potential involvement in CC proliferation, migration and invasion. Finally, the downstream regulatory genes of circYPEL2 were investigated by knockdown experiment in CC cell lines with high-throughput sequencing." 1 Impact of circ-0000221 in the Pathogenesis of Hepatocellular via Modulation of miR-661-PTPN11 mRNA Axis. hsa_circ_0000221 hsa_circ_VIM circ-0000221 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated Our study encourages further investigation of the role of circRNAs in cancer and their potential use as molecular biomarkers. 1 circHIPK3 Exacerbates Folic Acid-Induced Renal Tubulointerstitial Fibrosis by Sponging miR-30a. hsa_circ_0000284 hsa_circ_HIPK3 - DOID:0050855 renal fibrosis renal tubulointerstitial fibrosis RT-qPCR up-regulated Our results suggest that circHIPK3 may contribute to progressive renal fibrosis by sponging miR-30a. circHIPK3 may be a novel therapeutic target for slowing CKD progression. 1 Circular RNA circFGFR1 Functions as an Oncogene in Glioblastoma Cells through Sponging to hsa-miR-224-5p. - hsa_circ_FGFR1 circFGFR1 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated our findings suggest that circFGFR1 plays a critical role in the tumorigenic behaviors in glioma cells by upregulating CXCR4 expression via sponging to hsa-miR-224-5p. These findings provide a new perspective on circRNAs during GBM development. 1 Knockdown circZNF131 Inhibits Cell Progression and Glycolysis in Gastric Cancer Through miR-186-5p/PFKFB2 Axis. - hsa_circ_ZNF131 circZNF131 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circZNF131 could exert an oncogenic role in GC malignant development through the miR-186-5p/PFKFB2 axis, which might provide novel targets for GC treatment." 1 Circular RNA circ_0005835 promotes promoted neural stem cells proliferation and differentiate to neuron and inhibits inflammatory cytokines levels through miR-576-3p in Alzheimer disease. hsa_circ_0005835 - circ_0005835 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated These data suggested that circ_0005835 promoted AD development through regulating miR-576-3p expression. 1 Lidocaine represses the malignant behavior of lung carcinoma cells via the circ_PDZD8/miR-516b-5p/GOLT1A axis. - hsa_circ_PDZD8 circ_PDZD8 DOID:3905 lung carcinoma Lung carcinoma RT-qPCR up-regulated "Circ_PDZD8 might mitigate the inhibitory effect of Lido on tumor cell malignancy by modulating the miR-516b-5p/GOLT1A axis, providing a novel insight for lung carcinoma treatment." 1 Hsa_circRNA_0001971 contributes to oral squamous cell carcinoma progression via miR-186-5p/Fibronectin type III domain containing 3B axis. hsa_circ_0001971 - circRNA_0001971 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Overall, our study discovered that circRNA_0001971 was a tumor promoter in OSCC progression by targeting miR-186-5p/FNDC3B axis." 3 Hsa_circ_0050102 regulates the pancreatic cancer development via miR-218-5p/PPME1 axis. hsa_circ_0050102 hsa_circ_PGPEP1 circ_0050102 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated Hsa_circ_0050102 expedited the expansion of PC through growing PPME1 abundance by adjusting miR-218-5p. 1 Circular RNA hsa_circ_0000285 regulates the microRNA-599/G-protein subunit gamma 12 (miR-599/GNG12) axis to promote glioma progression. hsa_circ_0000285 hsa_circ_HIPK3 - DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Hsa_circ_0000285 is overexpressed in the glioma and promotes its progression by directly regulating the miR-599/GNG12 axis. This novel mechanism, therefore, shows that the hsa_circ_0000285/miR-599/GNG12 axis may be a promising therapeutic target for glioma treatment." 7 Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4/miR-34b-5p/c-Myc signaling. - hsa_circ_PHACTR4 circPHACTR4 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR down-regulated "Together, these results suggest that ERbeta may increase CSC population in ccRCC via altering ERbeta/circPHACTR4/miR-34b-5p/c-Myc signaling and that targeting this newly identified signal pathway may help physicians to better suppress ccRCC progression." 1 The novel role of circular RNA ST3GAL6 on blocking gastric cancer malignant behaviours through autophagy regulated by the FOXP2/MET/mTOR axis. - hsa_circ_ST3GAL6 circST3GAL6 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "In conclusion, our results suggested that circST3GAL6 played a tumour suppressive role in gastric cancer through miR-300/FOXP2 axis and regulated apoptosis and autophagy through FOXP2-mediated transcriptional inhibition of the MET axis, which may become a potential target for GC therapy." 1 Circular RNA hsa_circ_0069117 suppresses proliferation and migration of osteosarcoma cells lines via miR-875-3p/PF4V1 axis. hsa_circ_0069117 hsa_circ_TBC1D14 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "hsa_circ_0069117 is an anti-OS molecule that could substantially attenuate cell proliferation and migration of OS, which may provide a novel and reliable molecular target for the treatment of OS patients." 1 Circular RNA circZNF532 facilitates angiogenesis and inflammation in diabetic retinopathy via regulating miR-1243/CARM1 axis. - hsa_circ_ZNF532 circZNF532 DOID:8947 diabetic retinopathy Diabetic retinopathy RT-qPCR up-regulated "circZNF532 facilitated HG-induced angiogenesis and inflammation in hRMECs via modulating the miR-1243/CARM1 pathway, suggesting that circZNF532 might be a potential biomarker for DR treatment." 1 Estrogen receptor beta promotes lung cancer invasion via increasing CXCR4 expression. - hsa_circ_TMX4 circ-TMX4 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "Together, our findings suggest that ERbeta can promote NSCLC cell invasion via altering the ERbeta/circ-TMX4/miR-622/CXCR4 signaling, and targeting this newly circ-TMX4/miR-622/CXCR4 signaling may help us find new treatment strategies to better suppress NSCLC progression." 1 Estrogen receptor beta2 (ERbeta2)-mediated upregulation of hsa_circ_0000732 promotes tumor progression via sponging microRNA-1184 in triple-negative breast cancer (TNBC). hsa_circ_0000732 hsa_circ_SCARF1 circ_0000732 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Our present study found that ERbeta2 is upregulated in some TNBC cells and promotes TNBC cell growth, migration and invasion by regulating hsa_circ_0000732 targeting miR-1184. The special role of ERbeta2 in TNBC may be the breakthrough of a targeted treatment strategy for TNBC." 2 CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate Laryngeal Squamous Cell Carcinoma Progression. - hsa_circ_CORO1C Circ_CORO1C DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "In conclusion, circ_CORO1C is highly expressed in LSCC tissues and cells, and circ_CORO1C silencing repressed LSCC progression via regulating miR-654-3p/USP7 axis." 2 Circ-ATIC Serves as a Sponge of miR-326 to Accelerate Esophageal Squamous Cell Carcinoma Progression by Targeting ID1. - hsa_circ_ATIC Circ-ATIC DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "Our study showed that circ-ATIC facilitated the progression of ESCC by regulating the miR-326/ID1 axis, indicating that circ-ATIC might be a target for ESCC treatment." 2 Microarray profiling and functional analysis reveal the regulatory role of differentially expressed plasma circular RNAs in Hashimoto thyroiditis. hsa_circ_0008193 hsa_circ_FAM120A - DOID:7166 thyroiditis Hashimoto thyroiditis RT-qPCR up-regulated These results provide a comprehensive circRNA resource for further in-depth study of the regulatory mechanisms of circRNA in HT and may provide new insight into HT. 1 Hsa_circ_0001020 accelerates the lower extremity deep vein thrombosis via sponging miR-29c-3p to promote MDM2 expression. hsa_circ_0001020 hsa_circ_UGP2 circ_0001020 DOID:0060903 thrombosis deep vein thrombosis RT-qPCR up-regulated "Our finding demonstrated a novel signaling pathway involving hsa_circ_0001020, miR-29c-3p, MDM2, which might be a potential therapeutic target for DVT." 1 Roles of circ_0000135/miR-140-3p/PDZK1 network in cervical cancer. hsa_circ_0000135 - circ_0000135 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circ_0000135 may play an anti-tumor role on the progression of cervical cancer by sponging miR-140-3p to suppress the expression of PDZK1, providing a promising therapeutic target." 1 CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis. - hsa_circ_CBFB CircCBFB DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircCBFB inhibits miR-424-5p and upregulates ATG14, thus promoting HCC cell proliferation and autophagy." 1 Knockdown of circular RNA tousled-like kinase 1 relieves ischemic stroke in middle cerebral artery occlusion mice and oxygen-glucose deprivation and reoxygenation-induced N2a cell damage. - hsa_circ_TLK1 circTLK1 DOID:6713 cerebrovascular disease ischemic stroke RT-qPCR up-regulated "In conclusion, circTLK1 knockdown relieved IS via the miR-26a-5p/PTEN/IGF-1 R/GLUT1 axis. These results may provide a new direction to IS potential therapeutic targets." 3 Silencing circular RNAPTPN12 promoted the growth of keloid fibroblasts by activating Wnt signaling pathway via targeting microRNA-21-5p. - hsa_circ_PTPN12 circPTPN12 DOID:10881 "hand, foot and mouth disease" keloid RT-qPCR down-regulated "Taken together, silencing circPTPN12 promotes the growth of keloid fibroblasts by activating Wnt pathway targeting miR-21-5p. CircPTPN12 may play a considerable part in keloid formation, which supplies a reference for molecularly targeted therapy keloid." 1 Circ-CUL2/microRNA-888-5p/RB1CC1 axis participates in cisplatin resistance in NSCLC via repressing cell advancement. - hsa_circ_CUL2 Circ-CUL2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated Circ-CUL2 is supposed to be a novel biomarker offering a brand-new strategy for NSCLC therapy. 2 Circular RNA Rbms1 inhibited the development of myocardial ischemia reperfusion injury by regulating miR-92a/BCL2L11 signaling pathway. - hsa_circ_Rbms1 circRbms1 DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR up-regulated "circRbms1 participated in myocardial I/R injury by regulating the miR-92a/BCL2L11 signaling pathway, which may provide a new strategy for the treatment of AMI." 1 Circular RNA hsa_circ_0006091 as a novel biomarker for hepatocellular carcinoma. hsa_circ_0006091 hsa_circ_RGS12 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated The joint diagnosis of the hsa_circ_0006091&AFP and hsa_circ_0006091&RGS12 has diagnostic significance and can be used as a molecular marker for HCC diagnosis. 1 Exosome-delivered circular RNA DLGAP4 induces chemoresistance via miR-143-HK2 axis in neuroblastoma. - hsa_circ_DLGAP4 circDLGAP4 DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated "In conclusion, these findings demonstrate that exosome-delivered circDLGAP4 promotes the glycolysis, proliferation, and invasion of sensitive NB cells by regulating miR-143 and HK2, providing a novel link between drug resistance and circDLGAP4/miR-143/HK2 axis in drug-resistant NB." 1 CircACC1 Promotes NSCLC Proliferation via miR-29c-3p/MCL-1 Signaling Pathway. - hsa_circ_ACC1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Elevated levels of circACC1 were found in NSCLC patients and were negatively correlated with OS. Ectopic expression of circACC1 promoted the capacity of cell growth and clonogenicity, while the inhibition of circACC1 decreased the proliferation and clonogenicity potential." 1 Circular RNA CCDC66 Improves Murine Double Minute 4 (MDM4) Expression through Targeting miR-370 in Colorectal Cancer. - hsa_circ_CCDC66 circCCDC66 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "In summary, our results indicate that circCCDC66 is a key upregulation of CRC. circCCDC66 upregulates MDM4 through competitive binding to miR-370, thereby enhancing the metastatic ability of CRC cells and promoting the development of CRC." 4 CircRNA_400029 promotes the aggressive behaviors of cervical cancer by regulation of miR-1285-3p/TLN1 axis. - - CircRNA_400029 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "The overexpressed circRNA_400029 promoted CC proliferation, migration and invasion while deduced apoptosis by sponging miR-1285-3p to regulate TLN1. CircRNA_400029 was a potential onco-circRNA in CC, and might be a promised therapy target." 1 "CircRNA-ACAP2 contributes to the invasion, migration, and anti-apoptosis of neuroblastoma cells through targeting the miRNA-143-3p-hexokinase 2 axis." - hsa_circ_ACAP2 CircRNA-ACAP2 DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated "Our study revealed biological roles and molecular mechanisms for circ-ACAP2 in the oncogenic characteristics of neuroblastoma, facilitating the development of circRNA-based treatment approaches for anti-brain tumor therapy." 1 CircWHSC1 Promotes Breast Cancer Progression by Regulating the FASN/AMPK/mTOR Axis Through Sponging miR-195-5p. hsa_circ_0001387 hsa_circ_WHSC1 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "As shown by the result, circWHSC1 was up-regulated in BC tissues versus adjacent non-tumor tissues. circWHSC1 overexpression was correlated with higher tumor stages, lymphatic metastasis and worse survival of BC patients. Functionally, overexpressing circWHSC1 amplified proliferation, migration and invasion of BC cell lines and boosted xenograft tumor growth in nude mice." 2 Construction and analysis of the ceRNA network hsa_circ_0031968/miR-3611/GCG in lung adenocarcinoma. hsa_circ_0031968 hsa_circ_FERMT2 - DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" up-regulated The ceRNA regulatory network hsa_circ_0031968/miR-3611/GCG was successfully constructed and this provided novel insights into the identification of biomarkers and the pathogenesis of LUAD. This knowledge will contribute to the early diagnosis and development of potential treatment for patients with LUAD. 2 circVAMP3 Drives CAPRIN1 Phase Separation and Inhibits Hepatocellular Carcinoma by Suppressing c-Myc Translation. - hsa_circ_VAMP3 circVAMP3 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated circVAMP3 is a potential prognostic indicator for HCC and may serve as a therapeutic target for HCC treatment. 1 The circROBO1/KLF5/FUS feedback loop regulates the liver metastasis of breast cancer by inhibiting the selective autophagy of afadin. - hsa_circ_ROBO1 circROBO1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Our results demonstrated that circROBO1 facilitates the carcinogenesis and liver metastasis of BC through the circROBO1/KLF5/FUS feedback loop, which inhibits the selective autophagy of afadin by suppressing the transcription of BECN1. Therefore, circROBO1 could be used not only as a potential prognostic marker but also as a therapeutic target in BC." 1 Mechanism of CircANKRD36 regulating cell heterogeneity and endothelial mesenchymal transition in aortic valve stromal cells by regulating miR-599 and TGF-beta signaling pathway. - hsa_circ_ANKRD36 CircANKRD36 DOID:62 aortic valve disease calcific aortic valve disease RT-qPCR down-regulated "circANKRD36 can inhibit the expression of miR-599 and the activation of TGF-beta signaling pathway, thus inhibiting the expression of differentiation-related factors of VIC osteogenesis and the formation of calcified nodules. Therefore, circANKRD36-miR-599-TGF-beta axis can be a new theoretical basis for treating CAVD." 1 Hsa_circ_0074269-mediated Upregulation of TUFT1 Through miR-485-5p Increases Cisplatin Resistance in Cervical Cancer. hsa_circ_0074269 hsa_circ_ANKHD1-EIF4EBP3 circ_0074269 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Circ_0074269 facilitated DDP resistance via elevating TUFT1 expression via sponging miR-485-5p, proving novel evidence to offer circ_0074269 as a target for cervical cancer treatment." 1 Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2-mediated autophagy. - hsa_circ_CPM circCPM DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated Our results reveal that circCPM has a crucial role in regulating GC autophagy and 5-FU resistance by targeting PRKAA2. It may function as a new theory basis for assessing the curative effect of GC and reversing 5-FU chemoresistance. 1 Identification of a Novel circ_0010235/miR-1249-3p/HOXA13 Axis in Lung Adenocarcinoma. hsa_circ_0010235 - circ_0010235 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated Our findings demonstrate that the circ_0010235/miR-1249-3p/HOXA13 axis is implicated in the pathogenesis of LUAD. 1 Circ-LTBP1 is involved in doxorubicin-induced intracellular toxicity in cardiomyocytes via miR-107/ADCY1 signal. - hsa_circ_LTBP1 Circ-LTBP1 DOID:114 heart disease doxorubicin-induced intracellular toxicity in cardiomyocytes RT-qPCR up-regulated "Circ-LTBP1 was found to enhance DOX-induced effects on proliferation inhibition, inflammation, apoptosis, and oxidative stress in AC16 cells through competitively sponging miR-107 and elevating ADCY1." 2 Circ_0003611 acts as a miR-885-5p sponge to aggravate the amyloid-beta-induced neuronal injury in Alzheimer disease. hsa_circ_0003611 - Circ_0003611 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated These experimental data demonstrated that circ_0003611 enhanced the Abeta-induced neuronal cell injury in AD by serving as the miR-885-5p sponge to regulate the level of KREMEN1. 3 [Effect of circ-SFMBT2 on the biological behavior of non-small cell lung cancer cells by targeting the miR-7-5p/ADAM10 axis]. - hsa_circ_SFMBT2 circ-SFMBT2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Silencing circ-SFMBT2 can suppress the proliferation, clone formation, invasion ability and induce apoptosis of NSCLC cells by regulating the miR-7-5p/ADAM10 axis." 4 CircRNA PRH1-PRR4 stimulates RAB3D to regulate the malignant progression of NSCLC by sponging miR-877-5p. - hsa_circ_PRH1-PRR4 circPRH1-PRR4 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircPRH1-PRR4 knockdown impeded NSCLC cell malignancy by the miR-877-5p/RAB3D pathway, providing a possible circRNA-targeted therapy for NSCLC." 4 Serum exosomal hsa_circ_0069313 has a potential to diagnose more aggressive non-small cell lung cancer. hsa_circ_0069313 hsa_circ_PACRGL circ_0069313 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Serum and serum exosomal hsa_circ_0069313 have the potential to discriminate NSCLC and benign lung tumor. The higher levels of serum exosomal hsa_circ_0069313 are linked to more aggressive pathological features of NSCLC. 1 CircRNA_0040705 promotes the progression of hepatocellular carcinoma. hsa_circ_0040705 - CircRNA_0040705 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0040705 facilitates HCC cell growth, migration, and invasion by down-modulating miR-557 expression and up-modulating SOX2 expression." 1 Circular RNA_0033596 aggravates endothelial cell injury induced by oxidized low-density lipoprotein via microRNA-217-5p /chloride intracellular channel 4 axis. hsa_circ_0033596 - circ_0033596 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "All in all circ_0033596 aggravates ox-LDL-induced HUVEC apoptosis by regulating the miR-217-5p/CLIC4 axis, by which circ_0033596 participates in the pathogenesis of AS." 1 Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer. - hsa_circ_LPAR3 circ-LPAR3 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "To sum up, circ-LPAR3 might contribute to the DDP resistance of OC via the miR-634/PDK1 axis." 1 Hsa_circ_0006677 regulates special AT-rich binding protein-2-mediated tumor-suppressive effect via functioning as a miR-1245a sponge in non-small cell lung cancer. hsa_circ_0006677 hsa_circ_WDR78 circ_0006677 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "In conclusion, circ_0006677 regulated SATB2-mediated tumor-suppressive effect via acting as a miR-1245a sponge in NSCLC, providing a new mechanism for understanding the progression of NSCLC." 2 "TGF-beta2-induced circ-PRDM5 regulates migration, invasion, and EMT through the miR-92b-3p/COL1A2 pathway in human lens epithelial cells." - hsa_circ_PRDM5 circ-PRDM5 DOID:0070353 cataract posterior capsule opacification RT-qPCR up-regulated "In summary, TGF-beta2-induced circ-PRDM5 facilitated LEC migration, invasion, and EMT by adsorbing miR-92b-3p and increasing COL1A2 expression, offering new insights into the development of PCO." 1 circFIG 4 drives the carcinogenesis and metastasis of esophagus cancer via the miR-493-5p/E2F3 axis. - hsa_circ_FIG circFIG DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "circFIG 4 silence mitigated EC malignant progression at least partly by mediating the miR-493-5p/E2F3 pathway, highlighting new biomarkers and therapeutic targets for EC treatment." 1 CircCHMP5 Contributes to Ox-LDL-induced Endothelial Cell Injury Through the Regulation of MiR-532-5p/ROCK2 axis. - hsa_circ_CHMP5 CircCHMP5 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "To sum up, our data showed that circCHMP5 regulated the miR-532-5p/ROCK2 axis to accelerate ox-LDL-induced HUVECs injury, confirming that circCHMP5 might be a potential target for AS treatment." 3 Circ_0039569 Competes with MARCKS for miR-133b Binding Sites to Promote the Progression of Renal Cell Carcinoma. hsa_circ_0039569 - Circ_0039569 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "Diminished circ_0039569 restrains the growth and propagation of RCC cells via miR-133b/MARCKS axis, indicating an underlying effective therapeutic target for RCC patients." 1 Hsa_circ_0060927 Is a Novel Tumor Biomarker by Sponging miR-195-5p in the Malignant Transformation of OLK to OSCC. hsa_circ_0060927 hsa_circ_CYP24A1 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated Hsa_circ_0060927 acted as a potential key ceRNA to sponge downstream miR-195-5p and promote OLK carcinogenesis by upregulating TRIM14. Hsa_circ_0060927 was expected to be a molecular marker for the prevention and treatment of OLK carcinogenesis through the hsa_circ_0060927/miR-195-5p/TRIM14 axis. 1 Circular RNA circZCCHC6 contributes to tumorigenesis by regulating LPCAT1 via miR-433-3p in non-small cell lung cancer. - hsa_circ_ZCCHC6 circZCCHC6 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircZCCHC6 inhibited the progression of NSCLC cells partly by regulating the miR-433-3p/LPCAT1 axis, implying a promising therapeutic target for the NSCLC treatment." 1 "Circ_0011385 knockdown inhibits cell proliferation, migration and invasion, whereas promotes cell apoptosis by regulating miR-330-3p/MYO6 axis in colorectal cancer." hsa_circ_0011385 - Circ_0011385 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0011385 regulated CRC process by miR-330-3p/MYO6 axis through MEK1/2/ERK1/2 signaling pathway, providing a novel therapeutic target for CRC." 1 Endoplasmic reticulum stress promotes breast cancer cells to release exosomes circ_0001142 and induces M2 polarization of macrophages to regulate tumor progression. hsa_circ_0001142 hsa_circ_miR-361-3p circ_0001142 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated it was found that the circ_0001142/miR-361-3p/PIK3CB pathway plays an important role in the polarization of macrophages. 1 Tumor-associated macrophages promote cholangiocarcinoma progression via exosomal Circ_0020256. hsa_circ_0020256 hsa_circ_NSMCE4A circ_0020256 DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR up-regulated "In conclusion, Circ_0020256 in TAM-secreted exosomes promoted the proliferation, migration, and invasion of CCA cells, and that promotional activity was regulated via a Circ_0020256/miR-432-5p/E2F3 axis." 1 CircVPS13C promotes pituitary adenoma growth by decreasing the stability of IFITM1 mRNA via interacting with RRBP1. - hsa_circ_VPS13C CircVPS13C DOID:3829 pituitary adenoma pituitary adenoma RT-qPCR up-regulated "Our findings suggest that circVPS13C is a critical regulator in the proliferation and development of NFPAs through a novel mechanism, whereby regulating mRNA stability via interacting with ribosome-binding proteins on the endoplasmic reticulum membrane." 1 Circ-ITCH overexpression promoted cell proliferation and migration in Hirschsprung disease through miR-146b-5p/RET axis. - hsa_circ_ITCH Circ-ITCH DOID:10487 Hirschsprung disease Hirschsprung disease RT-qPCR down-regulated Circ-ITCH overexpression facilitated cell proliferation and migration in HSCR by regulating miR-146b-5p/RET/MAPK axis. 1 "Circ_0001947 promotes cell proliferation, invasion, migration and inflammation and inhibits apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes through miR-671-5p/STAT3 axis." hsa_circ_0001947 - circ_0001947 DOID:848 arthritis arthritis RT-qPCR up-regulated Circ_0001947 contributed to the progression of RA-FLSs by elevating STAT3 through adsorbing miR-671-5p. 1 Circ-LARP1B knockdown restrains the tumorigenicity and enhances radiosensitivity by regulating miR-578/IGF1R axis in hepatocellular carcinoma. - hsa_circ_LARP1B Circ-LARP1B DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ-LARP1B knockdown restrained HCC tumorigenicity and enhanced radiosensitivity by regulating miR-578/IGF1R axis, providing a new target for the treatment of HCC." 2 Comprehensive Assessment of Serum hsa_circ_0070354 as a Novel Diagnostic and Predictive Biomarker in Non-small Cell Lung Cancer. hsa_circ_0070354 hsa_circ_PTPN13 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" up-regulated Hsa_circ_0070354 is not only a novel sensitive index for the diagnosis of NSCLC but also a crucial marker for bad biological behavior. 1 Circ-ADAM9 Promotes High Glucose-Induced Retinal Pigment Epithelial Cell Injury in DR via Regulating miR-338-3p/CARM1 Axis. - hsa_circ_ADAM9 circ-ADAM9 DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR up-regulated "Circ-ADAM9 contributed to HG-induced ARPE9 cell injury by regulating miR-338-3p/CARM1 axis, which provided effective targets for DR treatment." 1 The Function of circRNA-0047604 in Regulating the Tumor Suppressor Gene DACH1 in Breast Cancer. hsa_circ_0047604 hsa_circ_SMAD2 circRNA-0047604 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "In conclusion, this study revealed that hsa_circ_0047604 acted as a tumor suppressor and regulated breast cancer progression via hsa_circ_0047604-miR-548o-DACH1 axis, which might provide a therapeutic method for breast cancer." 1 "Circ_0009910 Serves as miR-361-3p Sponge to Promote the Proliferation, Metastasis, and Glycolysis of Gastric Cancer via Regulating SNRPA." hsa_circ_0009910 - Circ_0009910 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "our data showed that circ_0009910 might be a target for GC treatment, which could promote GC proliferation, metastasis, and glycolysis by the miR-361-3p/SNRPA axis." 2 Circular RNA circSLC8A1 inhibits the proliferation and invasion of glioma cells through targeting the miR-214-5p/CDC27 axis. - hsa_circ_SLC8A1 circSLC8A1 DOID:0060108 brain glioma glioma RT-qPCR down-regulated "Taken together, our results demonstrated a tumor suppressive role of circSLC8A1 in glioma through regulation of glioma cells proliferation and invasion. The effects of circSLC8A1 were mediated by miR-214-5p/CDC27 axis. Our study provided a new understanding of the occurrence and development of gliom." 1 Potential roles of hsa_circ_000839 and hsa_circ_0005986 in breast cancer. hsa_circ_000839 - circ_000839 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "Downregulation of hsa_circ_000839 and hsa_circ_0005986 in BC tumors suggests a tumor-suppressive role for these circRNAs in BC, meriting the need for more experimentations to delineate the exact mechanism of their involvement in BC pathogenesis." 1 Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis. - hsa_circ_DIDO1 circDIDO1 DOID:409 liver disease liver failure RT-qPCR down-regulated "Clinically, low levels of serum circDIDO1 in exosome were correlated with liver failure, and serum exosomal circDIDO1 had a well diagnostic value for liver fibrosis in liver failure patients. Transfer of circDIDO1 mediated by MSC-isolated exosomes suppressed HSC activation through the miR-141-3p/PTEN/AKT pathway, gaining a new insight into the prevention of liver fibrosis in liver failure patients." 1 "Circ-SWT1 Ameliorates H(2)O(2)-Induced Apoptosis, Oxidative Stress and Endoplasmic Reticulum Stress in Cardiomyocytes via miR-192-5p/SOD2 Axis." - hsa_circ_SWT1 Circ-SWT1 DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR down-regulated "Circ-SWT1 ameliorates H2O2-induced apoptosis, oxidative stress and ER stress in cardiomyocytes via miR-192-5p/SOD2 axis, suggesting the potential involvement of circ-SWT1 in AMI process." 1 Circular RNA 0000654 facilitates the growth of gastric cancer cells through absorbing microRNA-149-5p to up-regulate inhibin-beta A. hsa_circ_0000654 - circ_0000654 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circ_0000654 facilitates the growth of GC cells through absorbing miR-149-5p to up-regulate INHBA. 1 CircFAM53B promotes the proliferation and metastasis of glioma through activating the c-MET/PI3K/AKT pathway via sponging miR-532-3p. - hsa_circ_FAM53B CircFAM53B DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Conclusively, circFAM53B aggravated glioma progression by up-regulating the c-MET/PI3K/AKT pathway and down-regulating miR-532-3p. Thus, the circFAM53B/miR-532-3p/c-MET/PI3K/AKT axis is a potential treatment target for glioma." 1 Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1. - hsa_circ_CSPP1 circCSPP1 DOID:219 colon cancer colon cancer RT-qPCR up-regulated "Taken together, the findings of the present study indicated that circCSPP1 may function as a competing endogenous RNA in the progression of colon cancer by regulating the miR-431/ROCK1 and miR-431/ZEB1 signaling axes." 1 "Circ_0002577/miR-126-5p/MACC1 axis promotes endometrial carcinoma progression by regulation of proliferation, migration, invasion, and apoptosis of endometrial carcinoma cells." hsa_circ_0002577 - Circ_0002577 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "The contributions of the circ_0002577 in EC were contributed to its interactions with miR-126-5p and MACC1, which offered a new perspective to the roles of circ_0002577 in EC." 4 CircTMOD3 promotes lipopolysaccharide-induced chondrocyte apoptosis in osteoarthritis by sponging miR-27a. - hsa_circ_TMOD3 circTMOD3 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated CircTMOD3 suppresses miR-27a maturation in OA to promote chondrocyte apoptosis induced by LPS. 1 SiRNA-circFARSA-loaded porous silicon nanomaterials for pancreatic cancer treatment via inhibition of CircFARSA expression. - hsa_circ_FARSA circFARSA DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "Therefore, this study provides tools for pancreatic cancer treatment in the future, as it (1) verified circFARSA as a novel target for pancreatic cancer treatment, and (2) prepared a novel anti-pancreatic cancer agent (pSiNP-PEI-siRNA-circFARSA)." 1 Circ_0072088 knockdown contributes to cisplatin sensitivity and inhibits tumor progression by miR-944/LASP1 axis in non-small cell lung cancer. hsa_circ_0072088 - Circ_0072088 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0072088 silencing improved CDDP sensitivity and inhibited NSCLC progression by downregulating LASP1 expression through sponging miR-944. These data provide novel insight into the resistance of NSCLC to CDDP. 3 Knockdown of circ-RAD23B inhibits non-small cell lung cancer progression via the miR-142-3p/MAP4K3 axis. - hsa_circ_RAD23B circ-RAD23B DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ-RAD23B knockdown inhibited NSCLC development by regulating the miR-142-3p/MAP4K3 axis, which might be associated with the inactivation of the MAPK signaling pathway." 3 Circular RNA circ_0000518 promotes breast cancer progression through the microRNA-1225-3p/SRY-box transcription factor 4 pathway. hsa_circ_0000518 - circ_0000518 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "In conclusion, circ_0000518 is oncogenic in BC and functions through miR-1225-3p/SOX4 axis." 1 Hsa_circ_0001756 promotes ovarian cancer progression through regulating IGF2BP2-mediated RAB5A expression and the EGFR/MAPK signaling pathway. hsa_circ_0001756 hsa_circ_HIPK2 circ_0001756 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "In conclusion, hsa_circ_0001756 knockdown inhibits OC cell proliferation, invasion, and EMT, and reduces xenograft tumor growth by suppressing IGF2BP2-mediated RAB5A expression and blocking the EGFR/MAPK signaling pathway." 3 Circular RNA circ_UBAP2 facilitates the progression of osteosarcoma by regulating microRNA miR-637/high-mobility group box (HMGB) 2 axis. - hsa_circ_UBAP2 circ_UBAP2 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ_UBAP2 plays a promoting role in OS, and the circ_UBAP2/miR-637/HMGB2 axis is involved in OS progression." 5 Upregulation of exosomal circPLK1 promotes the development of non-small cell lung cancer through the miR-1294/ high mobility group protein A1 axis. - hsa_circ_PLK1 circPLK1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Our study suggests that circPLK1 upregulation plays an important role in NSCLC progression by targeting miR-1294/HMGA1 axis. These data provide a theoretical basis for the development of therapeutic strategy targeting exosomal circPLK1 in NSCLC treatment. 1 hsa_circ_0111707 Is Associated With Risk of Stress-Related Type 2 Diabetes via Sponging miR-144-3p. hsa_circ_0111707 hsa_circ_IPO9 - DOID:9352 type 2 diabetes mellitus type 2 diabetes RT-qPCR up-regulated hsa_circ_0111707 is associated with risk of T2D development via sponging miR-144-3p. hsa_circ_0111707 in PBMCs can be considered a potential biomarker of stress-related T2D. 1 "Identification of a novel circRNA, hsa_circ_0065898, that regulates tumor growth in cervical squamous cell carcinoma." hsa_circ_0065898 hsa_circ_VPRBP - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "We demonstrated that hsa_circ_0065898 promoted CSCC cell proliferation, migration, and invasion. Hence, hsa_circ_0065898 might be useful as a biomarker for CSCC diagnosis and targeted therapy." 4 Circular RNA hsa_circ_0002124 promotes hepatocellular carcinoma cell proliferation through the MAPK pathway. hsa_circ_0002124 hsa_circ_NUSAP1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circular RNA hsa_circ_0002124 promotes hepatocellular carcinoma cell proliferation through the MAPK pathway. 1 "Circular RNA SMARCA5 is overexpressed and promotes cell proliferation, migration as well as invasion while inhibits cell apoptosis in bladder cancer." - hsa_circ_SMARCA5 - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Circ-SMARCA5 is overexpressed, and promotes cell proliferation, migration and invasion, but represses apoptosis in bladder cancer." 1 STAT3 activation regulated circ-STAT346 promote expression of IGF1R by sponging of miR-139-5p in human colon cancer. - hsa_circ_STAT346 circ-STAT346 DOID:219 colon cancer colon cancer RT-qPCR up-regulated "circ-STAT3.46 was regulated by IGF/IGF1R/STAT3 activation, and overexpression of circ-STAT3.46 can up-regulate IGF1R by sponging of miR-139-5p within human colon cancer." 1 Down-regulated hsa_circ_0067934 facilitated the progression of gastric cancer by sponging hsa-mir-4705 to downgrade the expression of BMPR1B. hsa_circ_0067934 hsa_circ_PRKCI - DOID:10534 stomach cancer gastric cancer RNA-seq up-regulated Down-regulated hsa_circ_0067934 facilitated the progression of gastric cancer by sponging hsa-mir-4705 to downgrade the expression of BMPR1B. 3 N6-methyladenosine-dependent modification of circGARS acts as a new player that promotes SLE progression through the NF-kappaB/A20 axis. hsa_circ_0009000 hsa_circ_GARS circGARS DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR up-regulated The circGARS sponges miR-19a to regulate YTHDF2 expression to promote SLE progression through the A20/NF-¦ĘB axis and may act as an independent biomarker to help the treatment of SLE patients. 1 CircZNF652 promotes the goblet cell metaplasia by targeting the miR-452-5p/JAK2 signaling pathway in allergic airway epithelia. - hsa_circ_ZNF652 CircZNF652 DOID:0080817 T2-high asthma goblet cell metaplasia of asthma "RT-qPCR, microarray" up-regulated "Upregulation of circZNF652 expression in allergic bronchial epithelia contributed to the goblet cell metaplasia by activating the miR-452-5p/JAK2/STAT6 signaling pathway; thus, blockage of circZNF652 or agonism of miR-452-5p provided an alternative approach for the therapeutic intervention of epithelial remodeling in allergic airway inflammation." 1 Andrographolide suppresses osteoarthritis progression by regulating circ_Rapgef1/miR-383-3p/NLRP3 signaling axis. - mmu_circ_Rapgef1 circ_Rapgef1 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Circ_Rapgef1 suppressed AD-mediated protective effects in OA partly by regulating miR-383-3p/NLRP3 signaling. 1 Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA. - hsa_circ_PRMT5 circPRMT5 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR dysregulated The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer. 1 Identification of plasma hsa_circ_0000190 and 0001649 as biomarkers for predicting the recurrence and treatment response of patients with oral squamous cell carcinoma. hsa_circ_0000190 hsa_circ_CNIH4 circ_0000190 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "Our study demonstrated the potential of biomarkers in plasma to inform not just the tumor but the entire oral cavity, thereby offering a prediction for early recurrence and second primary OSCC. The plasma circRNAs remain valuable for OSCC, albeit the easy accessibility to the oral cavity." 1 Cardioprotective Effect of circ_SMG6 Knockdown against Myocardial Ischemia/Reperfusion Injury Correlates with miR-138-5p-Mediated EGR1/TLR4/TRIF Inactivation. - hsa_circ_SMG6 circ_SMG6 DOID:1287 cardiovascular system disease myocardial ischemia-reperfusion injury RT-qPCR up-regulated "Overall, our findings suggest that circ_SMG6 may deteriorate myocardial I/R injury by promoting neutrophil recruitment via the miR-138-5p/EGR1/TLR4/TRIF signaling. This pathway may represent a potential therapeutic target in the management of myocardial I/R injury." 1 circ_ZFR Is Linked to Paclitaxel Resistance in Cervical Cancer via miR-944 Sponging and IL-10 Upregulation. - hsa_circ_ZFR circ_ZFR DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circ_ZFR knockdown has a considerable role in overwhelming CC-associated PTX resistance by modifying the axis of miR-944/IL-10 axis, suggesting that developing a circRNA target-based treatment could be considered prevent CC progression." 2 Therapeutic Potential of Exosomes Derived From circRNA_0002113 Lacking Mesenchymal Stem Cells in Myocardial Infarction. hsa_circ_0002113 hsa_circ_IFNGR2 - DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated "In conclusion, exosomes derived from circRNA_0002113 lacking MSCs could suppress myocardial infarction by sponging miR-188-3p to regulate RUNX1 nuclear translocation. The circRNA_0002113/miR-188-3p/RUNX1 axis mediated alleviation of apoptosis serves as a novel strategy to treat myocardial I/R injury." 1 Identification of circular RNAs and functional competing endogenous RNA networks in human proximal tubular epithelial cells treated with sodium-glucose cotransporter 2 inhibitor dapagliflozin in diabetic kidney disease. - - hsa_circRNA_012448 DOID:557 kidney disease diabetic kidney disease "RT-qPCR, microarray" up-regulated our study provides novel insights into the molecular mechanisms underlying the effects of dapagliflozin on DKD. 1 Hsa_circ_0039569 facilitates the progression of endometrial carcinoma by targeting the miR-197/high mobility group protein A1 axis. hsa_circ_0039569 hsa_circ_CCL22 circ_0039569 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "Collectively, hsa_circ_0039569 may promote the development of endometrial carcinoma by serving as an endogenous sponge of miR-197, increasing HMGA1 expression and identifying a novel target for endometrial carcinoma treatment." 3 YAP derived circ-LECRC functions as a brake signal to suppress hyperactivation of oncogenic YAP signalling in colorectal cancer.. - hsa_circ_LECRC circ-LECRC DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "In summary, circ-LECRC regulates KLF4 expression by functioning as a competing endogenous RNA and serves as a brake signal to suppress hyperactivation of oncogenic YAP signalling, leading to tumour growth inhibition in CRC." 1 CircCAMSAP1 promotes non-small cell lung cancer proliferation and inhibits cell apoptosis by sponging miR-1182 and regulating BIRC5. - hsa_circ_CAMSAP1 CircCAMSAP1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" up-regulated "Together, our findings reveal a novel mechanism by which the circCAMSAP1/miR-1182/BIRC5 axis promotes NSCLC progression." 1 Depleting hsa_circ_0000567 suppresses acquired gefitinib resistance and proliferation of lung adenocarcinoma cells through regulating the miR-377-3p / ZFX axis: an in vitro and in vivo study. hsa_circ_0000567 hsa_circ_SETD3 circ_0000567 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "The hsa_circ_0000567/miR-377-3p/ZFX axis might contribute to acquired gefitinib resistance in LUAD cells both in vitro and in vivo, suggesting hsa_circ_0000567 as a novel therapeutic target in treatment of gefitinib-resistant LUAD." 2 Circ_0004015 silencing represses cisplatin chemoresistance and tumor progression by reducing KLF8 in a miR-198-dependent manner in non-small cell lung cancer. hsa_circ_0004015 - Circ_0004015 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0004015 conferred DDP resistance and promoted NSCLC progression by miR-198/KLF8 pathway, proving a potential target for studying DDP-mediated treatment of NSCLC." 2 CircRNA ZNF609 promotes the growth and metastasis of thyroid cancer in vivo and in vitro by downregulating miR-514a-5p. - hsa_circ_ZNF609 circ-ZNF609 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated The findings highlighted the importance of circ-ZNF609 function in facilitating TC cell development and metastasis_n vitro_nd_n vivo_ia binding to miR-514a-5p. 1 "circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-beta/Smad signaling." - hsa_circ_PTEN1 "circPTEN1," DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Our study uncovered a novel PTEN gene-generated circRNA with a tumor suppression function, and further revealed the mechanism of circPTEN1 in CRC metastasis mediated by TGF-beta The identification of circPTEN1 provides a new direction for PTEN investigation, and elucidation of circPTEN1/TGF-beta/Smad signaling may pave the way for the development of a potential therapeutic strategy for the suppression of cancer progression." 1 Hsa_circ_0134111 promotes intervertebral disc degeneration via sponging miR-578. hsa_circ_0134111 hsa_circ_PDE1C circ_0134111 DOID:90 degenerative disc disease Intervertebral disc degeneration RT-qPCR up-regulated "These data suggested that circ_0134111 could promote the progression of IDD through enhancing aberrant NP cell growth, inflammation, and ECM degradation partly via regulating miR-578." 1 MiR-21-5p-expressing bone marrow mesenchymal stem cells alleviate myocardial ischemia/reperfusion injury by regulating the circRNA_0031672/miR-21-5p/programmed cell death protein 4 pathway. hsa_circ_0031672 rno_circ_RALGAPA1 circRNA_0031672 DOID:1287 cardiovascular system disease myocardial ischemia-reperfusion injury RT-qPCR up-regulated "We identified a novel circRNA_0031672/miR-21-5p/PDCD4 signaling pathway that mediates the apoptosis of cardiomyocytes and successfully alleviates IRI in myocardial cells by co-culture with miR-21-5p-expressing BMSCs, offering novel insights into the IRI pathogenesis in cardiovascular diseases." 1 Circular RNA circCHFR downregulation protects against oxidized low-density lipoprotein-induced endothelial injury via regulation of microRNA-15b-5p/growth arrest and DNA damage inducible gamma. - hsa_circ_CHFR circCHFR DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "In conclusion, circCHFR promotes atherosclerosis progression via the miR-15b-5p/GADD45G axis and may be an important target for atherosclerosis treatment." 6 Exosomal circ_0001190 Regulates the Progression of Gastric Cancer via miR-586/SOSTDC1 Axis. hsa_circ_0001190 - circ_0001190 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Exosomal circ_0001190 overexpression inhibited the development of GC by miR-586/SOSTDC1 axis, which proposed a potential targeted therapy for GC cure." 2 Circular RNA Derived from Vacuolar ATPase Assembly Factor VMA21 Suppresses Lipopolysaccharide-Induced Apoptosis of Chondrocytes in Osteoarthritis (OA) by Decreasing Mature miR-103 Production. - hsa_circ_VMA21 circVMA21 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "In conclusion, VMA21 might suppress LPS-induced chondrocyte apoptosis in OA by decreasing the production of mature miR-103." 1 Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/ nuclear factor -kappa B (NF-kappaB) pathway. - hsa_circ_ZFR circZFR DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "In general, CAFs-derived exosomes deliver circZFR to HCC cells, inhibit the STAT3/NF-¦ĘB pathway, and promote HCC development and chemoresistance. The results provided a new sight for the prevention and treatment of chemoresistance in HCC." 4 The circRNA circSIAE Inhibits Replication of Coxsackie Virus B3 by Targeting miR-331-3p and Thousand and One Amino-Acid Kinase 2. hsa_circ_0000367 hsa_circ_SIAE circSIAE DOID:0050117 disease by infectious agent Coxsackie virus B3 RT-qPCR down-regulated "circSIAE can target_AOK2_hrough sponge adsorption of miR-331-3p to inhibit the replication and proliferation of CVB3 virus, providing an early molecular target for the diagnosis of CVB3 infection." 1 Circ_0026579 alleviates LPS-induced WI-38 cells inflammation injury in infantile pneumonia. hsa_circ_0026579 - Circ_0026579 DOID:10533 viral pneumonia infantile pneumonia RT-qPCR up-regulated "Circ_0026579 positively regulated IGF2 expression through sponging miR-24-3p. Circ_0026579 knockdown alleviated LPS-induced WI-38 cells inflammation by miR-24-3p/IGF2 axis, suggesting that circ_0026579 might contribute to infantile pneumonia progression." 1 Circ_0120175 promotes laryngeal squamous cell carcinoma development through up-regulating SLC7A11 by sponging miR-330-3p. hsa_circ_0120175 - Circ_0120175 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "Circ_0120175 promoted proliferation, migration and invasion while impeded cell apoptosis of LSCC cells through miR-330-3p/SLC7A11 axis, which provided novel therapeutic targets for LSCC." 1 Exosomal circTAOK1 contributes to diabetic kidney disease progression through regulating SMAD3 expression by sponging miR-520h. - hsa_circ_TAOK1 circTAOK1 DOID:557 kidney disease diabetic kidney disease RT-qPCR up-regulated "GEC-circTAOK1-Exo could boost proliferation, fibrosis, and EMT of GMC through targeting the miR-520h/SMAD3 axis, providing new insights into the pathogenesis of DN." 3 CircKDM4B suppresses breast cancer progression via the miR-675/NEDD4L axis. - hsa_circ_KDM4B CircKDM4B DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "Collectively, these findings uncovered the tumor-suppressor role of circKDM4B in breast cancer, especially in angiogenesis and tumor metastasis, indicating that circKDM4B could be a potential therapeutic target for breast cancer progression." 1 Circ-0036602 Acts As a Sponge of MiR-34a-5p and MiR-431-5p to Promote Cervical Cancer Proliferation and Invasion. hsa_circ_0036602 - Circ-0036602 DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" up-regulated "Taken together, our findings suggest that circ0036602 is a tumor-promoting circRNA that promotes CC cells by sponging miR-34-5p and miR-431-5p to regulate HMGB1. Circ0036602 has huge prospects as a potential therapeutic target for CC patients." 1 Circular RNA HIPK3 aggravates sepsis-induced acute kidney injury via modulating the microRNA-338/forkhead box A1 axis. - hsa_circ_HIPK3 circHIPK3 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated "In sum, our results elaborated that circHIPK3 knockdown attenuated LPS-triggered HK2 cell injury by regulating FOXA1 expression via interacting with miR-338, suggesting that circHIPK3 might be a potential biomarker and therapeutic target for sepsis-induced AKI patients." 2 Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness. - hsa_circ_RHOBTB3 circRHOBTB3 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circRHOBTB3 plays a tumor-suppressive role in CRC and has to be excreted out of cells to sustain cancer cell fitness. ASOs targeting regulatory elements for circularization and exosomal secretion will become a novel antitumor strategy. 3 Luteolin activates M2 macrophages and suppresses M1 macrophages by upregulation of hsa_circ_0001326 in THP-1 derived macrophages. hsa_circ_0001326 - - DOID:2841 asthma Asthma RT-qPCR up-regulated These findings provide a new insight for macrophage polarization under stimulation of luteolin. 1 Circular RNA CDK6 suppresses cervical cancer proliferation and metastasis by sponging miR-449a. - hsa_circ_CDK6 circCDK6 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated The circCDK6 participated in tumorigenesis and cancer progression and might serve as a tumor suppressive factor in cervical cell progression via Epithelial-MesenchymalTransition (EMT) process by regulating miR-449a. 1 Nuclear genome-derived circular RNA circPUM1 localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma. - hsa_circ_PUM1 circPUM1 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "Therefore, we conclude that circPUM1 plays a critical role in maintaining the stability of mitochondrial complex III to enhance oxidative phosphorylation for ATP production of ESCC cells and moreover propose that ESCC cells exploit circPUM1 during cell adaptation." 1 Circular RNA CDR1as Alleviates Cisplatin-Based Chemoresistance by Suppressing MiR-1299 in Ovarian Cancer. hsa_circ_0001946 hsa_circ_CDR1 "ciRS-7, CDR1as" DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated Our findings interpret the underlying mechanisms of the CDR1as/miR-1299/PPP1R12B axis and shed light on the clinical applications for CDDP-chemoresistant OC. 3 hsa_circ_0139402 Promotes Bladder Cancer Progression by Regulating hsa-miR-326/PAX8 Signaling. hsa_circ_0139402 hsa_circ_PTCH1 circ_0139402 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0139402 plays a oncogene in BC and that can effectively promote cell proliferation, migration, invasion, and EMT by targeting Paired Box Protein Pax-8 (PAX8) via hsa-miR-326 and provides a potential therapeutic target for BC patients." 1 Circular CDC like kinase 1 suppresses cell apoptosis through miR-18b-5p/Y-box protein 2 axis in oral squamous cell carcinoma. - hsa_circ_CLK1 Circ-CLK1 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Therefore, circ-CLK1 inhibited the apoptosis of OSCC cells through the miR-18b-5p/YBX2 axis, and these findings suggest that circ-CLK1 could be a potential therapeutic target for OSCC patients." 1 Effect of circRNA_FOXO3 rs12196996 polymorphism and FOXO3 rs2232365 polymorphism on survival rate and severity of intensive care unit-acquired sepsis. - hsa_circ_FOXO3 circRNA_FOXO3 DOID:0040085 bacterial sepsis ICU-acquired sepsis RT-qPCR down-regulated This study revealed that the minor allele of rs12196996 polymorphism and rs2232365 polymorphism collaboratively contributed to the increased survival and suppressed severity of ICU-acquired sepsis. 1 CircMMD_007 promotes oncogenic effects in the progression of lung adenocarcinoma through microRNA-197-3p/protein tyrosine phosphatase non-receptor type 9 axis. - hsa_circ_MMD CircMMD_007 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "In summary, this research demonstrated that circular RNA circMMD_007 could promote the oncogenic effects in the progression of LC through miR-197-3p/PTPN9 axis." 1 Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3-eIF3h interaction. - hsa_circ_LPAR1 circLPAR1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated This comprehensive study highlights plasma exosomal circLPAR1 as a promising predictor in CRC diagnosis and describes its biological regulation of colorectal tumorigenesis. This study provides a new perspective on early diagnosis in the clinic and pathogenesis in disease development. 1 Circular RNA circ_IRAK3 contributes to tumor growth through upregulating KIF2A via adsorbing miR-603 in breast cancer. - hsa_circ_IRAK3 circ_IRAK3 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circ_IRAK3 exerted a promoting effect on BC progression by modulating the miR-603/KIF2A axis, providing a piece of novel evidence for circ_IRAK3 as a therapeutic target for BC." 2 METTL14-mediated m(6)A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis. - hsa_circ_ORC5 circORC5 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Our findings demonstrate that METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis. 1 Expression and clinical significance of circular RNA hsa_circ_0003416 in pediatric pulmonary arterial hypertension associated with congenital heart disease. hsa_circ_0003416 hsa_circ_TMSB4X - DOID:14557 primary pulmonary hypertension pediatric pulmonary arterial hypertension RT-qPCR down-regulated hsa_circ_0003416 was found to be significantly downregulated in children with PAH-CHD and to be potent as a biomarker for PAH-CHD diagnosis. 1 Cisplatin resistance and malignant behaviors of lung cancer cells are promoted by circ_0002360 via targeting miR-6751-3p to regulate the expression of ZNF300. hsa_circ_0002360 - circ_0002360 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "Circ_0002360 targeted miR-6751-3p to regulate ZNF300 level, thus elevating DDP resistance and promoting the malignant progression of lung cancer cells." 2 circRNA_0000285 knockdown suppresses viability and promotes apoptosis of cervical cancer cells by sponging microRNA-654-3p. hsa_circ_0000285 - circRNA_0000285 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circRNA_0000285 knockdown suppressed cell viability and promoted apoptosis by targeting miR-654-3p in CC. 4 "Circ_0072008, an oncogene in pancreatic ductal adenocarcinoma, contributes to tumour cell malignant progression and glycolysis by regulating miR-545-3p/SLC7A11 axis." hsa_circ_0072008 - "Circ_0072008," DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated "Circ_0072088 elicited oncogenic role in malignant cell progression and glycolysis of PDAC cells through circ_0072088/miR-545-3p/SLC7A11 pathway.HighlightsCirc_0072088 was upregulated in PDAC tumours and was associated with high tumour burden.Blocking circ_0072088 suppressed cell proliferation, migration, invasion, and glycolysis in PDAC cells.Circ_0072088 could directly regulate miR-545-3p, and SLC7A11 was a target of miR-545-3p.Restoring miR-545-3p mimicked the effects of circ_0072088 knockdown in PDAC cell_n vitro." 1 "Circ_0016347 modulates proliferation, migration, invasion, cell cycle, and apoptosis of osteosarcoma cells via the miR-661/IL6R axis." hsa_circ_0016347 - Circ_0016347 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circ_0016347 functioned as an oncogene in osteosarcoma at least in part by the miR-661/IL6R axis and JAK2/STAT3 signalling pathway. 2 Circ_0010235 facilitates lung cancer development and immune escape by regulating miR-636/PDL1 axis. hsa_circ_0010235 - Circ_0010235 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Circ_0010235 knockdown inhibited lung cancer progression and increased antitumor immunity by regulating the miR-636/PDL1 axis. 2 Circular RNA AXL increases neuron injury and inflammation through targeting microRNA-328 mediated BACE1 in Alzheimer disease. - hsa_circ_AXL circ-AXL DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated Circ-AXL may serve as a potential treatment target via miR-328 mediated BACE1 in AD. 3 Downregulation of mmu_circ_0000943 ameliorates renal ischemia reperfusion-triggered inflammation and oxidative stress via regulating mmu-miR-377-3p/Egr2 axis. mmu_circ_0000943 - - DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" up-regulated "This study suggested that mmu_circ_0000943 participated in progression of renal IRI by sponging miR-377-3p with Egr2, providing a new insight into AKI treatment." 1 Circular RNA circ_0068464 combined with microRNA-383 regulates Wnt/beta-catenin pathway to promote the progression of colorectal cancer. hsa_circ_0068464 - circ_0068464 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ_0068464 targets miR-383 to regulate Wnt/beta-catenin pathway activation, thereby promoting the development of CRC." 1 CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer. - hsa_circ_CDK17 CircCDK17 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "CircCDK17 knockdown repressed cell proliferation, migration, invasion and glycolysis, and promoted cell apoptosis via miR-1294/YWHAZ axis in CC. This finding provides a theoretical basis in studying circRNA-mediated therapy in CC." 4 Hsa_circ_0003945 promotes progression of hepatocellular carcinoma by mediating miR-34c-5p/LGR4/beta-catenin axis activity. hsa_circ_0003945 hsa_circ_UBAP2 circ_0003945 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "In conclusion, Circ_0003945 exerts a tumour-promoting role in HCC cells by regulating the miR-34c-5p/LGR4/beta-catenin axis, which may be a potential target for HCC therapy." 4 Circ_0020123 enhances the cisplatin resistance in non-small cell lung cancer cells partly by sponging miR-140-3p to regulate homeobox B5 (HOXB5). hsa_circ_0020123 - Circ_0020123 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "These results revealed that circ_0020123 promoted DDP resistance in NSCLC cells partly by targeting miR-140-3p/HOXB5 axis, indicating that circ_0020123 might be used as a molecular target in DDP treatment for NSCLC." 9 Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis. hsa_circ_0005230 hsa_circ_DNM3OS circ_0005230 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Overall, hsa_circ_0005230 could enhance the EMT phenotype by promoting RHOT1 expression through sponging miR-1299, thus affecting the biological behavior of GC. Hsa_circ_0005230 can be easily identified as a potential diagnostic biomarker and assessment prognosis target for GC." 1 "Disrupting circ-GNB4 mitigates high glucose-induced human mesangial cells injury by regulating the proliferation, ECM accumulation, inflammation and oxidative stress through circ-GNB4/miR-23c/EGR1 pathway [RETRACTED]." hsa_circ_0068087 hsa_circ_GNB4 circ-GNB4 DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "Collectively, circ-GNB4 might be a novel mechanism of DN-induced HRMCs injury, and there was a circ-GNB4/miR-23c/EGR1 pathway underlying the proliferation, extracellular matrix accumulation, inflammation and oxidative stress. This study suggested circ-GNB4 as a potential target to interfere the development of DN." 2 CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis. - hsa_circ_PVT1 circPVT1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated CircPVT1 mediates proliferation and chemoresistance of OS cells via the miR-24-3p/KLF8 axis. The findings may provide guidance for clinical treatment of OS. 5 circPlekha7 suppresses renal fibrosis via targeting miR-493-3p/KLF4. - hsa_circ_Plekha7 circPlekha7 DOID:0050855 renal fibrosis renal fibrosis RT-qPCR down-regulated circPlekha7 inhibits epithelial to mesenchymal transition of renal tubular epithelial cells and fibrosis via targeting miR-493-3p to de-repress KLF4/mitofusin2 expression. 1 "Circ_0008365 Suppresses Apoptosis, Inflammation and Extracellular Matrix Degradation of IL-1beta-treated Chondrocytes in Osteoarthritis by Regulating miR-324-5p/BMPR2/NF-kappaB Signaling Axis." hsa_circ_0008365 - circ_0008365 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Circ_0008365 reduced IL-1beta-induced cell damage in chondrocytes via inactivating NF-¦ĘB signaling pathway and regulating miR-324-5p/BMPR2 axis. 2 Circular RNA VMA21 ameliorates lung injury in septic rat via targeting microRNA-497-5p/CD2-associated protein axis. - hsa_circ_VMA21 circVMA21 DOID:0040085 bacterial sepsis sepsis RT-qPCR down-regulated "In conclusion, this work showed circVMA21 improved LI in sepsis rats by targeting miR-497-5p/CD2AP axis, suggesting that circVMA21 may be a novel therapeutic target for sepsis-induced LI." 2 Circ-AFAP1 promote clear cell renal cell carcinoma growth and angiogenesis by the Circ-AFAP1/miR-374b-3p/VEGFA signaling axis. - hsa_circ_AFAP1 Circ-AFAP1 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, RNA-seq" up-regulated "In conclusion, the circAFAP1/miR-374b-3p/VEGFA axis played a critical role in the progression and development of ccRCC which might be novel biological marks and therapeutical targets." 1 Investigating Urinary Circular RNA Biomarkers for Improved Detection of Renal Cell Carcinoma. - hsa_circ_EGLN3 - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated We observed significantly reduced levels of circEGLN3 and circSOD2 in urine from ccRCC patients compared to healthy controls. 2 Investigating Urinary Circular RNA Biomarkers for Improved Detection of Renal Cell Carcinoma. - hsa_circ_SOD2 - DOID:4451 renal carcinoma renal carcinoma RT-qPCR up-regulated We observed significantly reduced levels of circEGLN3 and circSOD2 in urine from ccRCC patients compared to healthy controls. 1 Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts. hsa_circ_0006867 hsa_circ_LRBA - DOID:10881 "hand, foot and mouth disease" keloid dermal fibroblasts RT-qPCR up-regulated "Taken together, our research provided multiple novel clues to understand the pathophysiologic mechanism of keloids and identified hsa_circ_0006867 as a biomarker of keloids." 1 Icaritin-elevated circ_0000190 suppresses the malignant progression of multiple myeloma by targeting miR-301a. hsa_circ_0000190 - circ_0000190 DOID:9538 multiple myeloma multiple myeloma RT-qPCR down-regulated This study enhanced the understanding of the mechanism of Icaritin associated with circRNAs in MM. 2 Circ_0001955 plays a carcinogenic role in breast cancer via positively regulating GLUT1 via decoying miR-1299. hsa_circ_0001955 - Circ_0001955 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_0001955 was found to promote breast cancer malignant development via targeting of the miR-1299/GLUT1 pathway, which contributes to our understanding of the pathogenesis of breast cancer." 2 Regulation of microRNA miR-197-3p/CDC28 protein kinase regulatory subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285 promotes glioma progression. hsa_circ_0000285 hsa_circ_HIPK3 circ_0000285 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Thus, circ_0000285 boosted glioma progression by regulating the miR-197-3p/CKS1B axis, highlighting a novel competing endogenous RNA circuit of glioma progression." 7 CircPAG1 interacts with miR-211-5p to promote the E2F3 expression and inhibit the high glucose-induced cell apoptosis and oxidative stress in diabetic cataract. - hsa_circ_PAG1 CircPAG1 DOID:13328 diabetic cataract diabetic cataract RT-qPCR down-regulated This study clarified that circPAG1 protected human lens epithelial cells from the high glucose-induced cell damages by the mediation of miR-211-5p/E2F3 axis. 1 Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-beta Signaling Axis in Pancreatic Cancer. hsa_circ_0005785 hsa_circ_ANAPC7 circANAPC7 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "This study identified circANAPC7 as a novel tumor suppressor, which functions through the CREB-miR-373-PHLPP2 axis, leading to AKT dephosphorylation, and cyclin D1 and transforming growth factor-beta down-regulation to suppress tumor growth and muscle wasting in pancreatic cancer." 1 Circ_FURIN knockdown assuages Testosterone-induced human ovarian granulosa-like tumor cell disorders by sponging miR-423-5p to reduce MTM1 expression in polycystic ovary syndrome. - hsa_circ_FURIN Circ_FURIN DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RT-qPCR up-regulated Circ_FURIN silencing protected against TTR-induced dysfunction by the miR-423-5p/MTM1 pathway in human ovarian granulosa-like tumor cells. 2 circKL inhibits the growth and metastasis of kidney cancer by sponging miR_182_5p and upregulating FBXW7. hsa_circ_0100312 hsa_circ_KL circKL DOID:263 kidney cancer kidney cancer RT-qPCR down-regulated "Overall, the circKL/miR_182_5p/FBXW7 axis was indicated to have a key role in the growth and metastasis of kidney cancer and may be targeted as a novel therapeutic strategy." 1 Circ_0067934 reduces JNK phosphorylation through a microRNA-545-3p/PPA1 axis to enhance tumorigenesis and cisplatin resistance in ovarian cancer. hsa_circ_0067934 - Circ_0067934 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated This study suggests that circ_0067934 sequesters miR-545-3p and enhances PPA1 expression to promote tumorigenesis and DDP resistance in OC. This study may provide novel approaches in the management of OC. 1 Silencing of circ_OSBPL10 affects the functional behaviors of oral squamous cell carcinoma cells by the miR-299-3p/CDK6 axis. - hsa_circ_OSBPL10 circ_OSBPL10 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Our present findings first demonstrate that circ_OSBPL10 can regulate the functional behaviors of OSCC cells at least partially by miR-299-3p/CDK6 axis, highlighting circ_OSBPL10 as a promising therapeutic target for OSCC." 1 Circular RNA_0061587 is associated with the tumorigenesis of neurofibromatosis type 1. hsa_circ_0061587 - circ_0061587 DOID:111253 neurofibromatosis 1 neurofibromatosis type 1 RT-qPCR up-regulated "In conclusion, circ_0061,587 functioned as an oncogene in NF1-associated MPNST cells and this study might provide novel insights for the diagnosis and treatment of NF1." 1 Circ_0006873 Sponges miR-142-5p to Inhibit Osteoblastic Differentiation of hBMSCs via Regulating PTEN/Akt Signaling Pathway. hsa_circ_0006873 - Circ_0006873 DOID:11476 osteoporosis osteoporosis RT-qPCR up-regulated "Circ_0006873 sponges miR-142-5p thereby enhances PTEN expression to suppress osteoblastic differentiation via regulation of Akt signaling pathway, thus, may provide a treatment approach for osteoporosis." 1 Circ_0061140 Contributes to the Malignant Progression in Ovarian Cancer Cells by Mediating the RAB1A Level Through Sponging miR-361-5p. hsa_circ_0061140 hsa_circ_C20orf11 Circ_0061140 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated All results demonstrated that circ_0061140 promoted OC development by inhibiting miR-361-5p to upregulate the expression of RAB1A. 3 PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer. mmu_circ_0001845 - - DOID:9256 colorectal cancer colorectal cancer RNA-seq up-regulated Our results suggested that these human PRKAR2A-derived circRNAs could be novel candidates for distinguishing CAC patients and predicted the prognosis of CAC. 1 Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma. - - circRNA_101093 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis, and blocking exosome may be helpful for future LUAD treatment." 1 The circular RNA circ_0030018/miR-136/migration and invasion enhancer 1 (MIEN1) axis promotes the progression of polycystic ovary syndrome. hsa_circ_0030018 - circ_0030018 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RT-qPCR up-regulated "In summary, loss of circ_0030018 delayed the progression of PCOS via the miR-136/MIEN1 axis." 1 "Circular RNA PIP5K1A act as microRNA-552-3p sponge to regulates inflammation, oxidative damage in glucolipotoxicity-induced pancreatic INS-1 beta-cells via Janus kinase 1." - hsa_circ_PIP5K1A circPIP5K1A DOID:9352 type 2 diabetes mellitus type 2 diabetes RT-qPCR up-regulated our study suggested a novel involvement of circPIP5K1A in a cross talk between miR5523p/JAK1/STAT3 pathways in beta-cells as a new therapeutic target for T2DM. 1 Exosomal circ_PTPRA inhibits tumorigenesis and promotes radiosensitivity in colorectal cancer by enriching the level of SMAD4 via competitively binding to miR-671-5p. - hsa_circ_PTPRA circ_PTPRA DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Exosomal circ_PTPRA enhanced CRC cell radiosensitivity and inhibited CRC malignant development partially by regulating the miR-671-5p/SMAD4 pathway, hinting that exosomal circ_PTPRA might be used as a potential predicted and therapeutic target for CRC." 1 hsa_circ_0000218/hsa-miR-139-3p/SOX4 regulatory feedback circuit influences the proliferation and apoptosis of gastric cancer cells. hsa_circ_0000218 hsa_circ_DCLRE1C circ_0000218 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Collectively, the present study demonstrated that circ_0000218 upregulated SOX4 via downregulating miR-139-3p to promote GC progression." 1 CircRNA ACVR2A Sponges miR-1290 to Modulate Cell Progression in Gastric Cancer. - hsa_circ_ACVR2A circACVR2A DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circACVR2A competitively sponged miR-1290 and was exerted as a tumor suppressor gene oncogene via a circACVR2A/miR-1290 axis, suggesting it as a possible biomarker for GC therapy." 1 Hsa_circ_0048674 facilitates hepatocellular carcinoma progression and natural killer cell exhaustion depending on the regulation of miR-223-3p/PDL1. hsa_circ_0048674 hsa_circ_UHRF1 circ_0048674 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Hsa_circ_0048674 knockdown decelerated HCC progression through the mediation of the miR-223-3p/PDL1 axis. 2 Circ_0011232 contributes to hepatocellular carcinoma progression through miR-503-5p/AKT3 axis. hsa_circ_0011232 - Circ_0011232 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0011232 facilitated HCC progression via miR-503-5p/AKT3 axis, which might provide a novel treatment strategy for HCC." 1 CircRNA SOD2 motivates non-small cell lungs cancer advancement with EMT via acting as microRNA-2355-5p competing endogenous RNA to mediate calmodulin regulated spectrin associated proteins-2. - hsa_circ_SOD2 CircSOD2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated This innovative signaling axis CircSOD2/miR-2355-5p/CAMSAP2 illustrated the new horizon to investigate NSCLC tumorigenesis and provided new prognosis and treatment of NSCLC. 1 CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke. - hsa_circ_OGDH CircOGDH DOID:2316 brain ischemia acute ischemic stroke RT-qPCR up-regulated "These results demonstrate that CircOGDH is a potential therapeutic target for regulating ischemia neuronal viability, and is enriched in neuron-derived exosomes in the peripheral blood, exhibiting a predictive biomarker of penumbra in patients with AIS." 1 circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-kappaB signaling pathway. - hsa_circ_CUL2 circCUL2 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated "We showed that the circCUL2/miR-203a-5p/MyD88/NF-¦ĘB/IL6 axis contributes to the induction of iCAFs and established a distinct fibroblast niche for PDAC progression, which could help the development of strategies that selectively target tumor-promoting CAFs in PDAC." 1 CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition. hsa_circ_0001460 hsa_circ_NEIL3 circNEIL3 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated "Collectively, the circNEIL3/miR-1184/PIF1 axis that mediate pyroptosis induction may be a novel, promising therapeutic strategy for the clinical treatment of lung cancer." 1 circBIRC6 contributes to the development of non-small cell lung cancer via regulating microRNA-217/amyloid beta precursor protein binding protein 2 axis. - hsa_circ_BIRC6 circBIRC6 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircBIRC6 aggravated NSCLC cell progression by elevating APPBP2 via sponging miR-217, which might provide a fresh perspective on NSCLC therapy." 5 circ_0001821 Contributes to the Development of Cutaneous Squamous Cell Carcinoma by Regulating MicroRNA-148a-3p/EGFR Axis and Activating Phosphatidylinositol 3-Kinase/Akt Pathway. hsa_circ_0001821 - circ_0001821 DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma RT-qPCR up-regulated circ_0001821 functioned as a tumor promoter in CSCC via regulating the miR-148a-3p/EGFR axis and PI3K/Akt pathway. 1 Circular RNA triple functional domain promotes osteoarthritis development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis. - hsa_circ_TRIO circTRIO DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated The results of this study inform that the circTRIO/miR-136-5p/NAMPT axis is momentous in OA progression and is supposed to be a promising therapeutic target for some time. 2 Hsa_circ_0007059 promotes apoptosis and inflammation in cardiomyocytes during ischemia by targeting microRNA-378 and microRNA-383. hsa_circ_0007059 hsa_circ_ZNF720 circ_0007059 DOID:5844 myocardial infarction myocardial Infarction "RT-qPCR, microarray" up-regulated "Collectively, our findings suggest that circ_0007059 expression is upregulated in mice cardiomyocytes in response to oxidative stress and cardiac tissues of MI mouse model, suggesting its involvement in the pathogenesis of MI by targeting miR-378 and miR-383." 1 Circ_0020123 promotes NSCLC tumorigenesis via up-regulating KIAA1522 expression through miR-940. hsa_circ_0020123 - Circ_0020123 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "In all, circ_0020123 acted as an oncogene to promote the tumorigenesis of NSCLC via miR-940/KIAA1522 axis, suggesting a potential therapeutic target for NSCLC treatment." 9 Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4gamma2 axis. - hsa_circ_UBE2D2 circ-UBE2D2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "These results suggest that circ-UBE2D2 promotes the proliferation, migration and invasion but restrains apoptosis of lung cancer cells by regulating miR-376a-3p/EIF4G2 axis." 1 "Circular RNA SET domain protein 3 promotes nasopharyngeal carcinoma proliferation, cisplatin resistance, and protein kinase B / mammalian target of rapamycin pathway activation by modulating microRNA-147a expression." - hsa_circ_SETD3 circSETD3 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "In conclusion, the results of this study confirm that circSETD3 promotes NPC proliferation and DDP resistance by regulating miR-147a, and circSETD3/miR-147a axis may serve as a potential therapeutic target for NPC in the future." 2 Circ_0110251 overexpression alleviates IL-1beta-induced chondrocyte apoptosis and extracellular matrix degradation by regulating miR-3189-3p/SPRY1 axis in osteoarthritis. hsa_circ_0110251 - Circ_0110251 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated Circ_0110251 protected chondrocytes from IL-1beta-induced apoptosis and ECM degradation in OA_ia_ponging miR-3189-3p and elevating SPRY1. 1 Circ_0025033 deficiency suppresses paclitaxel resistance and malignant development of paclitaxel-resistant ovarian cancer cells by modulating the miR-532-3p/FOXM1 network. hsa_circ_0025033 - Circ_0025033 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated Circ_0025033 downregulation impaired PTX resistance and malignant activities of PTX-resistant OC cells by regulating the miR-532-3p/FOXM1 network. 4 Identification of Cardiac CircRNAs in Mice With CVB3-Induced Myocarditis. - mmu_circ_Arhgap32 circArhgap32 DOID:820 myocarditis myocarditis "RT-qPCR, RNA-seq" down-regulated Our data showed that cardiac circRNAs dysregulation is an important characteristic of viral myocarditis. 1 Circular RNA circ_0001459 accelerates hepatocellular carcinoma progression via the miR-6165/IGF1R axis. - - circ_0001459 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "we revealed that circ_0001459 could sponge miR-6165 and induce the upregulation of its downstream target IGF1R, thus significantly promoting the progression of HCC. Therefore, circ_0001459 could be a new potential therapeutic target for HCC patients." 1 CircRNA_0008194 functions as a ceRNA to promote invasion of hepatocellular carcinoma via inhibiting miR-190a/AHNAK signaling pathway. hsa_circ_0008194 - CircRNA_0008194 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Our results suggested that circ_0008194 may act as a sponge to adsorb miR-190a, thereby promoting the expression of AHNAK and promoting the metastasis of liver cancer tumors." 1 Circular RNA circHIPK3 is downregulated in diabetic cardiomyopathy and overexpression of circHIPK3 suppresses PTEN to protect cardiomyocytes from high glucose-induced cell apoptosis. - hsa_circ_HIPK3 circHIPK3 DOID:3978 extrinsic cardiomyopathy diabetic cardiomyopathy RT-qPCR up-regulated "Therefore, circHIPK3 may downregulate PTEN to protect cardiomyocytes from high glucose-induced cell apoptosis." 1 Circular RNA hsa_circ_0119412 contributes to tumorigenesis of gastric cancer via the regulation of the miR-1298-5p/zinc finger BED-type containing 3 (ZBED3) axis. hsa_circ_0119412 hsa_circ_PER2 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "hsa_circ_0119412 sponges_iR-1298-5p, which regulates ZBED3 expression. Silencing hsa_circ_0119412 inhibits the progression of GC, at least in part, by targeting the_iR-1298-5p/ZBED3 axis." 1 Circular RNA circSHPRH inhibits the malignant behaviors of bladder cancer by regulating the miR-942/BARX2 pathway. - hsa_circ_SHPRH circSHPRH DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "Taken together, our findings indicate that circSHPRH serves as a sponge of miR-942 to inhibit BCa progression by upregulating BARX2 expression, thereby inhibiting the Wnt/beta-catenin signaling pathway." 1 Circular RNA circBFAR promotes glioblastoma progression by regulating a miR-548b/FoxM1 axis. - hsa_circ_BFAR circBFAR DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "In conclusion, the present study demonstrated that a circBFAR/miR-548b/FoxM1 axis regulates the development of GBM and highlights potentially novel therapeutic targets for the treatment of GBM." 1 The circular RNA hsa_circ_0001394 promotes hepatocellular carcinoma progression by targeting the miR-527/UBE2A axis. hsa_circ_0001394 hsa_circ_TBC1D14 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq up-regulated "The present study suggested that hsa_circ_0001394 may function as a sponge to promote HCC progression by regulating the miR-527/UBE2A pathway. Thus, hsa_circ_0001394 may become a promising biomarker and potential therapeutic target in HCC treatment." 2 circEPS15 Overexpression in Hepatocellular Carcinoma Modulates Tumor Invasion and Migration. - hsa_circ_EPS15 circEPS15 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Collectively, our study reveals that endogenous circEPS15 plays a novel role in repressing HCC through the ceRNA network and encodes a functional protein." 1 Decreased Expression of circ_0000160 in Breast Cancer With Axillary Lymph Node Metastasis. hsa_circ_0000160 - circ_0000160 DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated A decreased expression of circ_0000160 was found in breast cancer with axillary lymph node metastasis. Circ_0000160 may have the potential to distinguish breast cancer with axillary lymph node metastasis from those without axillary lymph node metastasis. 1 circ_LRP6 contributes to osteosarcoma progression by regulating the miR_141_3p/HDAC4/HMGB1 axis. - hsa_circ_LRP6 circ_LRP6 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "In summary, the present study determined that circ_LRP6 knockdown inhibited the proliferation, migration and invasion of OS cells by regulating the miR_141_3p/HDAC4/HMGB1 axis." 2 Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma. hsa_circ_0072309 hsa_circ_LIFR circ_0072309 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated This study revealed a function of hsa_circ_0072309 promoting autophagy by p53 signaling pathway and enhancing TMZ sensitivity. These findings demonstrated that hsa_circ_0072309 may be a potential and promising target in designing the treatment strategy for GBM. 1 Hsa_circ_0041268 promotes NSCLC progress by sponging miR-214-5p/ROCK1. hsa_circ_0041268 hsa_circ_PRPF8 circ_0041268 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Together, results demonstrated that hsa_circ_0041268 acted as tumor promoter through novel hsa_circ_0041268/miR-214-5p/ROCK1 axis, which highlighted its potential as NSCLC therapeutic agent." 1 The novel circular RNA HIPK3 accelerates the proliferation and invasion of hepatocellular carcinoma cells by sponging the micro RNA-124 or micro RNA-506/pyruvate dehydrogenase kinase 2 axis. - hsa_circ_HIPK3 circHIPK3 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "We suggest that circHIPK3 can accelerate the proliferation and invasion of HCC cells by sponging miR-124 or miR-506 to upregulate PDK2, which is the underlying mechanism of circHIPK3-induced HCC progression." 6 Circular RNA mmu_circ_0001295 from hypoxia pretreated adipose-derived mesenchymal stem cells (ADSCs) exosomes improves outcomes and inhibits sepsis-induced renal injury in a mouse model of sepsis. mmu_circ_0001295 - mmu_circ_0001295 DOID:0040085 bacterial sepsis sepsis RNA-seq up-regulated "In summary, the data indicated that HExo elongate sepsis-induced renal injury through delivering mmu_circ_0001295." 1 "Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis." hsa_circ_0008896 hsa_circ_PPAPDC1A - DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Taken together, hsa_circ_0008896 regulated the expression of CDC20B by sponging hsa-miR-633, and then enhanced proliferation, migration, and invasion of VSMCs to promote the progression of atherosclerosis." 1 "Circular RNA midline-1 (circMID1) promotes proliferation, migration, invasion and glycolysis in prostate cancer." - hsa_circ_MID1 circMID1 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "In conclusion, our data confirmed that circMID1 might play a pro-cancer role in PCa, which promoted PCa progression through regulating the miR-330-3p/YTHDC2/IGF1R/AKT axis." 2 Circular RNA circRNA_0067934 promotes glioma development by modulating the microRNA miR-7/ Wnt/beta-catenin axis. hsa_circ_0067934 - circRNA_0067934 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "In conclusion, our results revealed that circRNA_0067934 regulates glioma cells progression by targeting miR-7/ Wnt/beta-catenin axis." 2 Silencing of circ-CDK14 suppresses osteosarcoma progression through the miR-198/E2F2 axis. - hsa_circ_CDK14 circ-CDK14 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Our findings demonstrate the inhibitory effect of circ-CDK14 silencing on OS progression by targeting the miR-198/E2F2 axis, establishing a strong rationale for decreasing circ-CDK14 as a novel therapeutic strategy for OS." 5 CircCYP24A1 hampered malignant phenotype of renal cancer carcinoma through modulating CMTM-4 expression via sponging miR-421. - hsa_circ_CYP24A1 CircCYP24A1 DOID:4451 renal carcinoma renal carcinoma "RT-qPCR, RNA-seq" up-regulated "Taken together, circCYP24A1 is a prognosis-related circRNA in RCC that functions through the circCYP24A1/miR-421/CMTM-4 axis to modulate RCC progression." 1 Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas. - hsa_circ_PKD2 Circ-PKD2 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "This study provides a theoretical basis for using circ-PKD2 as a target to regulate the sensitivity of OSCC patients to cisplatin, thus increasing its chemotherapeutic effects." 2 Circ_0008035 promotes the progression of gastric cancer via the regulation of miR-1256/CEACAM6 axis. hsa_circ_0008035 - Circ_0008035 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Collectively, circ_0008035 regulated the expression of CEACAM6 by sponging miR-1256, thereby promoting the development of GC. Our data provided a novel targeted therapy for GC." 4 Circular RNA Circ_0008043 promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating the microRNA (miR)-326/RAB21 axis. hsa_circ_0008043 - circ_0008043 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "In summary, silencing of circ_0008043 impeded HCC progression by regulating the miR-326/RAB21 axis. These data suggest that circ_0008043 may have clinical value in the treatment of HCC." 1 "Circular RNA Eps15-homology domain containing protein 2 motivates proliferation, glycolysis but refrains autophagy in non-small cell lung cancer via crosstalk with microRNA-3186-3p and forkhead box K1." - hsa_circ_EHD2 circEHD2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circEHD2 accelerates the proliferation and glycolysis of NSCLC, but refrains autophagy and apoptosis via strengthening FOXK1 via the adsorption of miR-3186-3p, which is supposed to be a latent molecular target for NSCLC therapy later." 1 "Circular RNA, hsa_circRNA_102049, promotes colorectal cancer cell migration and invasion via binding and suppressing miRNA-455-3p." - - hsa_circRNA_102049 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "The present study clearly demonstrated that miRNA-455-3p was a target of hsa_circRNA_102049. Moreover, the results indicated that the circular RNA, hsa_circRNA_102049, may function as a tumor promoter in CRC via directly sponging miRNA-455-3p." 1 Exosomal hsa_circ_0008925 from Urine Is Related to Chronic Renal Fibrosis. hsa_circ_0008925 hsa_circ_SEC63 circ_0008925 DOID:0050855 renal fibrosis renal fibrosis RT-qPCR up-regulated "In summary, we indicated that urinary exosomal hsa_circ_0008925 could be acted as a noninvasive biomarker for renal fibrosis in glomerular diseases patients." 1 Arterial Pulsatility Augments Microcirculatory Perfusion and Maintains the Endothelial Integrity during Extracorporeal Membrane Oxygenation via hsa_circ_0007367 Upregulation in a Canine Model with Cardiac Arrest. hsa_circ_0007367 - - DOID:114 heart disease extracorporeal membrane oxygenation RT-qPCR up-regulated The modification of pulsatility contributes to microcirculatory perfusion and endothelial integrity during ECMO. The expression of hsa_circ_0007367 plays a pivotal role in this protective mechanism. 2 Evaluating the Effect of Circ-Sirt1 on the Expression of SIRT1 and Its Role in Pathology of Pulmonary Hypertension. - hsa_circ_Sirt1 Circ-Sirt1 DOID:14557 primary pulmonary hypertension pulmonary arterial hypertension RT-qPCR up-regulated The findings of the present study indicate that circ-Sirt1 regulates the expression of SIRT1 mRNA and inhibits TGF-beta1/Smad3/Smad7 mediated proliferation and migration of PASMC. This provides a new insight into the molecular mechanism of pulmonary artery vascular remodeling in PAH and may aid in the development of novel therapeutic options for management of PAH. 1 circ_0089153 exacerbates breast cancer cells proliferation and metastasis via sponging miR-2467-3p/E2F6. hsa_circ_0089153 - circ_0089153 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circ_0089153 was an oncogene in breast cancer, which enhanced proliferation and metastasis through sponging miR-2467-3p/E2F6. circ_0089153 was suggested to be a potential target for BCa target treatment." 1 "Circ_0020123 regulates autophagy, glycolysis, and malignancy by upregulating IRF4 through eliminating miR-193a-3p-mediated suppression of IRF4 in non-small cell lung cancer." hsa_circ_0020123 - Circ_0020123 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0020123 promoted glycolysis and tumor growth by upregulating IRF4 through sequestering miR-193a-3p in NSCLC, offering a novel mechanism by which circ_0020123 is responsible for the malignancy, autophagy, and glycolysis of NSCLC cells." 9 Circular RNA circ_0020014 contributes to osteoarthritis progression via miR-613/ADAMTS5 axis. hsa_circ_0020014 - circ_0020014 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "circ_0020014 acted as a miR-613 sponge to regulate ADAMTS5 expression, thereby protecting chondrocytes from IL-1beta-induced inflammatory damage, which might be a novel diagnostic marker for OA." 2 Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop. - hsa_circ_CAMSAP1 circCAMSAP1 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "Our findings revealed that circCAMSAP1 promotes NPC proliferation and metastasis by binding to the 3UTR of SERPINH1, suggesting that the positive feedback of circCAMSAP1-SERPINH1-c-Myc may serve as a prognostic biomarker or therapeutic target in patients with NPC." 1 Novel circular RNA circ_0086722 drives tumor progression by regulating the miR-339-5p/STAT5A axis in prostate cancer. hsa_circ_0086722 - circ_0086722 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "In conclusion, our findings revealed that circ_0086722 drives PCa development via the miR-339-5p/STAT5A axis, and it may function as a potential prognostic biomarker or therapeutic target for PCa treatment. Further studies with large sample sizes and sufficiently long follow-up periods are necessary to confirm the predictive role of circ_0086722 for the prognosis of PCa patients." 1 Exosomal circ_0048856 derived from non-small cell lung cancer contributes to aggressive cancer progression through downregulation of miR-1287-5p. hsa_circ_0048856 - circ_0048856 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Exosomes derived circ_0048856 was elevated in NSCLC serum and cell lines. Exosome circ_0048856 promoted the NSCLC development by targeting miR-1287-5p. Exosome circ_0048856 had high diagnostic value for NSCLC. 1 Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis. - hsa_circ_SHKBP1 circSHKBP1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Thus, exosomal circSHKBP1 participated in the progression of NSCLC via the miR-1294/PKM2 axis. circSHKBP1 may be potential biomarker for the diagnosis and treatment of NSCLC." 1 CircAXL Knockdown Alleviates Abeta(1-42)-Induced Neurotoxicity in Alzheimer Disease via Repressing PDE4A by Releasing miR-1306-5p. - hsa_circ_AXL CircAXL DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated Exosomal circAXL and exosomal miR-1306-5p had diagnostic values for AD. CircAXL knockdown alleviates Abeta1-42-induced neurotoxicity in AD pathology via repressing PDE4A by releasing miR-1306-5p. 3 CircPTK2 inhibits cell cisplatin (CDDP) resistance by targeting miR-942/TRIM16 axis in non-small cell lung cancer (NSCLC). - hsa_circ_PTK2 CircPTK2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "circPTK2 weakened CDDP resistance of NSCLC through modulating miR-942/TRIM16 axis, providing a novel sight for the treatment of NSCLC and improving the understanding of the CDDP resistance mechanism of NSCLC." 3 "Circ_0085315 promotes cell proliferation, invasion, and migration in colon cancer through miR-1200/MAP3K1 signaling pathway." hsa_circ_0085315 - Circ_0085315 DOID:219 colon cancer colon cancer RT-qPCR up-regulated "In conclusion, circRNA_0085315 serves as a ceRNA and promotes CC progression through the activation of the MAPK signaling pathway mediated via the miR-1200/MAP3K1 axis, suggesting that circRNA_0085315 may be a promising diagnostic and therapeutic target for CC." 1 Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis. hsa_circ_0004662 hsa_circ_SOD2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Five circRNAs, including hsa_circ_0004662, hsa_circ_0005735, hsa_circ_0006990, hsa_circ_0018403 and hsa_circ_0100609, that may play key roles in the progression of HCC were identified." 3 Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis. hsa_circ_0005735 hsa_circ_EIF4G3 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Five circRNAs, including hsa_circ_0004662, hsa_circ_0005735, hsa_circ_0006990, hsa_circ_0018403 and hsa_circ_0100609, that may play key roles in the progression of HCC were identified." 4 Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis. hsa_circ_0006990 hsa_circ_VAPA - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Five circRNAs, including hsa_circ_0004662, hsa_circ_0005735, hsa_circ_0006990, hsa_circ_0018403 and hsa_circ_0100609, that may play key roles in the progression of HCC were identified." 2 Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis. hsa_circ_0018403 hsa_circ_SGMS1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Five circRNAs, including hsa_circ_0004662, hsa_circ_0005735, hsa_circ_0006990, hsa_circ_0018403 and hsa_circ_0100609, that may play key roles in the progression of HCC were identified." 1 Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis. hsa_circ_0100609 hsa_circ_ZC3H13 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "Five circRNAs, including hsa_circ_0004662, hsa_circ_0005735, hsa_circ_0006990, hsa_circ_0018403 and hsa_circ_0100609, that may play key roles in the progression of HCC were identified." 1 circ_AKT3 knockdown suppresses cisplatin resistance in gastric cancer. - hsa_circ_AKT3 circ_AKT3 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circ_AKT3 knockdown suppressed cisplatin resistance using miR-206/PTPN14 axis in cisplatin-resistant GC cells. 4 circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity. - hsa_circ_REEP3 circREEP3 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circREEP3-FKBP10 axis drives CRC progression and may be a critical prognostic marker. 1 A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2-positive breast cancer through regulating ferroptosis. - hsa_circ_BGN circ-BGN DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Collectively, our data reveal a novel circRNA controlling trastuzumab resistance via regulation of ferroptosis, providing a promising therapeutic strategy for trastuzumab-resistant breast cancer patients." 1 Circular RNA circPTK2 modulates migration and invasion via miR-136/NFIB signaling on triple-negative breast cancer cells in vitro. - hsa_circ_PTK2 circPTK2 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated CircPTK2 promoted TNBC progression and development. circPTK2/miR-136/NFIB might be an effective biomarker for TNBC. 2 CircWHSC1 expedites cervical cancer progression via miR-532-3p/LTBP2 axis. - hsa_circ_WHSC1 CircWHSC1 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated The circWHSC1-mediated miR-532-3p/LTBP2 signaling axis might be a novel therapeutic target for CaCx. 1 Circular RNA F-circEA-2a expression is increased in gastric adenocarcinoma and inhibits the transition from premature microRNA-3940-5p to mature microRNA-3940-5p. - - F-circEA-2a DOID:3717 gastric adenocarcinoma gastric adenocarcinoma RT-qPCR up-regulated Our study characterized a novel circRNA regulating miR-3940-5p maturation in GA. 1 Circular RNA ZNF609 promotes laryngeal squamous cell carcinoma progression by upregulating epidermal growth factor receptor via sponging microRNA-134-5p. - hsa_circ_ZNF609 CircZNF609 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "CircZNF609 promotes the progression of LSCC via the miR-134-5p/EGFR axis, which might be the therapeutic target of LSCC." 1 EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway. - hsa_circ_PRKCI circPRKCI DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Taken together, EIF4A3-mediated circPRKCI could promote TNBC progression by regulating WBP2 and PI3K/AKT signaling pathway, providing a new avenue of therapy for TNBC." 1 SP1-Mediated Upregulation of circFAM126A Promotes Proliferation and Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma via Regulation of RAB41. - hsa_circ_FAM126A circFAM126A DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "SP1 transcriptionally activated circFAM126A modulated the growth, epithelial-mesenchymal transition (EMT) of OSCC cells_ia_argeting the miR-186/FUS/RAB41 axis, suggesting that circFAM126A is a potential biomarker for the treatment of OSCC." 2 Circ_0076305 facilitates prostate cancer development via sponging miR-411-5p and regulating PGK1. hsa_circ_0076305 - Circ_0076305 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated Circ_0076305 served as a novel oncogene PCa progression through regulation of miR-411-5p/PGK1 axis. 1 Circ_0008500 Knockdown Improves Radiosensitivity and Inhibits Tumorigenesis in Breast Cancer Through the miR-758-3p/PFN2 Axis. hsa_circ_0008500 - Circ_0008500 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "In conclusion, circ_0008500 inhibition promoted the radiosensitivity and restrained the development of breast cancer by downregulating PFN2 expression via targeting miR-758-3p." 1 Circ_0016760 Serves as a Cancer Promoter in Non-small Cell Lung Cancer Through miR-876-3p/NOVA2 Axis. hsa_circ_0016760 - Circ_0016760 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0016760 could promote the malignant development of NSCLC through miR-876-3p/NOVA2 axis, at least in part." 6 Circ_0028007 Aggravates the Malignancy of Nasopharyngeal Carcinoma by Regulating miR-656-3p/ELF2 Axis. hsa_circ_0028007 - Circ_0028007 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated Circ_0028007 contributed to the progression of NPC by decoying miR-656-3p and elevating ELF2. The findings might provide potential targets for NPC therapy. 1 Circular RNA hsa_circ_0011385 contributes to cervical cancer progression through sequestering miR-149-5p and increasing PRDX6 expression. hsa_circ_0011385 hsa_circ_EIF3I - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In conclusion, hsa_circ_0011385 accelerated angiogenesis and malignant behaviors of CC cells by regulating the miR-149-5p/PRDX6 axis, manifesting that hsa_circ_0011385 might be a therapeutic target for CC." 2 Tumor promoting effect of circ_002172 associates with induced immune escape in breast cancer via the miR-296-5p/CXCL12 axis. - - circ_002172 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Moreover, Ectopic expression of circ_002172 inhibited cytotoxic T lymphocytes (CTL) infiltration to promote the immune escape of BC. In conclusion, the tumor-promoting role of circ_002172 in BC was achieved by inducing immune escape via the miR-296-5p/CXCL12 axis." 1 Circular RNA hsa_circ_0000277 promotes tumor progression and DDP resistance in esophageal squamous cell carcinoma. hsa_circ_0000277 hsa_circ_PDE3B - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "These findings unraveled that hsa_circ_0000277 promoted ESCC progression and DDP resistance via miR-873-5p/SOX4/Wnt/beta-catenin axis, showing a specific molecular mechanism of carcinogenesis and chemoresistance in ESCC." 3 CircRASSF2 promotes IGF1R and osteosarcoma metastasis via sponging miR-6838-5p. - hsa_circ_RASSF2 CircRASSF2 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "In conclusion, the promoting effects of IGF1R on OS are targeted by miR-6838-5p. CircRASSF2 restored the expression of IGF1R by sponging miR-6838-5p, thereby promoting the progression of OS." 1 Circular RNA hsa_circ_0077837 is upregulated in non-small cell lung cancer to downregulate phosphatase and tensin homolog through methylation. hsa_circ_0077837 hsa_circ_EPB41L2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated hsa_circ_0077837 is upregulated in NSCLC and downregulates PTEN by increasing its gene methylation to suppress cell apoptosis.List of abbreviations:Non-small cell lung cancer (NSCLC); circRNAs (circular RNAs); methylation-specific PCR (MSP). 2 Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer disease. - hsa_circ_PSEN1 circPSEN1 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated "Our findings show the differential expression of circPSEN1 is increased in ADAD. Given the biological function previously ascribed to circular RNAs and the results of our in-silico analyses, we hypothesize that this finding might be related to neuroinflammatory events that lead or that are caused by the accumulation of amyloid-beta." 1 The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis. hsa_circ_0012138 hsa_circ_ERI3 - DOID:0050855 renal fibrosis renal fibrosis microarray up-regulated "In conclusion, we for the first time demonstrated that circRNA_37492 attenuated renal fibrosis via targeting miR-7682-3p/Fgb axis, and the homologous hsa_circRNA_0012138 was speculated as a possible ceRNA to regulate multiple gene expressions and involve in human renal fibrosis, suggesting that circRNA_37492/hsa_circ_0012138 may serve as potent therapy target for obstructive renal fibrosis disease." 1 Circ_0000591 served as endogenous RNA for miR-326 to promote progression of cholangiocarcinoma via the TLR4/MyD88/IL6 axis. hsa_circ_0000591 - Circ_0000591 DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR up-regulated "In conclusion, this study revealed a novel regulatory mechanism that circ_0000591 contributed to the progression of CCA via miR-326/TLR4/MyD88/IL6 axis. These findings enhanced our knowledge of potential molecular mechanism involved in the malignant progression of CCA." 1 Circ_0037866 Contributes to the Tumorigenesis of Renal Cell Carcinoma by Sequestering miR-384 to Elevate Chromobox 5 Expression. hsa_circ_0037866 - Circ_0037866 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "Circ_0037866 knockdown restrains the tumorigenesis of RCC by miR-384/CBX5, revealing a promising molecular target for RCC therapy." 1 CircTRRAP Knockdown Has Cardioprotective Function in Cardiomyocytes via the Signal Regulation of miR-370-3p/PAWR Axis. hsa_circ_0081241 hsa_circ_TRRAP circTRRAP DOID:5844 myocardial infarction acute myocardial infarction RT-qPCR up-regulated These findings demonstrated that silence of circTRRAP exerted the protection against the hypoxia-induced damages in cardiomyocytes through regulating the miR-370-3p and PAWR levels. 1 Circular RNA circ0007360 Attenuates Gastric Cancer Progression by Altering the miR-762/IRF7 Axis. hsa_circ_0007360 - circ0007360 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "In summary, our results revealed that activation of the_irc0007360/miR-762/IRF7_xis is a novel mechanism for the attenuation of gastric cancer progression. Our study unveils the diagnostic and therapeutic values of_irc0007360_n patients with gastric cancer." 1 Has_circ_0008583 modulates hepatocellular carcinoma progression through the miR-1301-3p/METTL3 pathway. hsa_circ_0008583 hsa_circ_DLG1 circ_0008583 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "In conclusion, hsa_circ_0008583 promotes HCC progression through the miR-1301-3p/METTL3 axis." 3 Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM). - hsa_circ_ZNF652 circZNF652 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "Collectively, we concluded that targeting the circular RNA circZNF652/miR-486-5p/SERPINE1 axis was a novel and effective strategy to suppress cancer progression in GBM." 1 Circular RNA hsa_circ_0011324 is involved in endometrial cancer progression and the evolution of its mechanism. hsa_circ_0011324 hsa_circ_SPOCD1 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "In conclusion, hsa_circ_0011324 could sponge hsa-miR-497/16-5p targeted mTOR to participate in EC progress. Our study may provide a new therapeutic target for EC." 1 Circular RNA circ SET domain containing 2 (circSETD2) inhibits hepatocellular carcinoma cell proliferation and invasion in vivo and in vitro. - hsa_circ_SETD2 circSETD2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated These findings improve our understanding of the mechanisms of liver cancer progression and will guide future development of therapeutic strategies against the disease by targeting circ-SETD2. 1 A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing. - hsa_circ_HNRNPU circHNRNPU DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated Our findings demonstrate that circHNRNPU_603aa is a promising diagnostic and therapeutic marker in both MM cells and BM niche. 1 "Circular RNA circTADA2A promotes the proliferation, invasion, and migration of non-small cell lung cancer cells via the miR-450b-3p/HMGN5 signaling pathway." - hsa_circ_TADA2A circTADA2A DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "These findings suggest that circTADA2A might act as an oncogenic circRNA that promotes NSCLC progression by sponging miR-450b-3p and promoting HMGN5 expression, indicating that the suppression of circTADA2A could become a potential therapeutic target for restraining NSCLC." 6 Circular RNA UBAP2 facilitates the cisplatin resistance of triple-negative breast cancer via microRNA-300/anti-silencing function 1B histone chaperone/PI3K/AKT/mTOR axis. - hsa_circ_UBAP2 circUBAP2 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "In summary, this research revealed a novel regulatory mechanism that circUBAP2 functioned as ceRNA of miR-300 to upregulate ASF1B, which further triggered the PI3K/AKT/mTOR (PAM) signaling to enhance the DDP resistance of TNBC." 1 Knockdown of circ_0001679 alleviates lipopolysaccharide-induced MLE-12 lung cell injury by regulating the miR-338-3p/ mitogen-activated protein kinase 1 axis. hsa_circ_0001679 - circ_0001679 DOID:850 lung disease lung injury RT-qPCR up-regulated "Collectively, our study indicates that circ_0001679/miR-338-3p/MAPK1 axis may play an important role in the pathogenesis of acute lung injury (ALI)." 1 Circular RNA coiled-coil domain containing 66 regulates malignant development of papillary thyroid carcinoma by upregulating La ribonucleoprotein 1 via the sponge effect on miR-129-5p. - hsa_circ_CCDC66 circ-CCDC66 DOID:3969 thyroid gland papillary carcinoma papillary thyroid carcinoma RT-qPCR up-regulated "Circ-CCDC66 promoted PTC proliferation, migration, invasion, and tumor growth by sponging miR-129-5p and promoting LARP1 expression." 1 Hsa_circ_0000418 promotes the progression of glioma by regulating microRNA-409-3p / pyruvate dehydrogenase kinase 1 axis. hsa_circ_0000418 hsa_circ_CCT2 circ_0000418 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "In summary, circ_0000418 enhances glioma cell growth and accelerates cell cycle progression by regulating miR-409-3p/PDK1 axis." 1 Circular RNA_ANKIB1 accelerates chemo-resistance of osteosarcoma via binding microRNA-26b-5p and modulating enhancer of zeste homolog 2. - hsa_circ_ANKIB1 circ_ANKIB1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "In conclusion, Circ_ANKIB1 binds miR-26b-5p and modulates EZH2 to accelerate the chemo-resistance of osteosarcoma." 3 Hsa_Circ_0098181 Suppresses Hepatocellular Carcinoma by Sponging miR-18a-3p and Targeting PPARA. hsa_circ_0098181 hsa_circ_SOX5 Circ_0098181 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "In conclusion, hsa_circ_0098181 can repress the development of HCC through sponging miR-18a-3p and promoting the expression of PPARA_n vitro_nd_n vivo, and hsa_circ_0098181 might be a therapeutic target for HCC." 3 CircRNA_Maml2 promotes the proliferation and migration of intestinal epithelial cells after severe burns by regulating the miR-93-3p/FZD7/Wnt/beta-catenin pathway. - mmu_circ_Maml2 CircRNA_Maml2 DOID:37 skin disease injury and repair of intestinal mucosa RT-qPCR down-regulated "Our findings demonstrate that circRNA_Maml2 regulates the miR-93-3p/FZD7/Wnt/beta-catenin pathway and promotes the repair of damaged intestinal mucosa. Hence, circRNA_Maml2 is a potential therapeutic target to promote intestinal mucosal repair." 1 CircFOXM1 acts as a ceRNA to upregulate SMAD2 and promote the progression of nasopharyngeal carcinoma. - hsa_circ_FOXM1 CircFOXM1 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated CircFOXM1 promotes the malignant proliferation of nasopharyngeal carcinoma cells by regulating the miR-136-5p-SMAD2 axis. 1 "Knockdown of circ_0102273 inhibits the proliferation, metastasis and glycolysis of breast cancer through miR-1236-3p/PFKFB3 axis." hsa_circ_0102273 - circ_0102273 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "In summary, our research proposed that circ_0102273 might be a potential target for BC treatment, which could inhibit BC proliferation, metastasis and glycolysis through the miR-1236-3p/PFKFB3 axis." 1 "Circ-LRP1B functions as a competing endogenous RNA to regulate proliferation, apoptosis and oxidative stress of LPS-induced human C28/I2 chondrocytes." - hsa_circ_LRP1B Circ-LRP1B DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "These findings demonstrate that circ-LRP1B functions as a ceRNA to regulate the proliferation, apoptosis and oxidative stress of LPS-stimulated human C28/I2 chondrocytes by miR-34a-5p/NRF1 network." 1 circITCH suppresses cell proliferation and metastasis through miR-660/TFCP2 pathway in melanoma. - hsa_circ_ITCH circITCH DOID:1909 melanoma melanoma RT-qPCR down-regulated The circITCH/miR-660/TFCP2 axis is involved in melanoma progression hence circITCH can be a diagnostic biomarker as well as a target for treating melanoma. 2 hsa_circ_0058122 knockdown prevents steroid-induced osteonecrosis of the femoral head by inhibiting human umbilical vein endothelial cells apoptosis via the miR-7974/IGFBP5 axis. hsa_circ_0058122 hsa_circ_FN1 circ_0058122 DOID:10159 osteonecrosis osteonecrosis RT-qPCR up-regulated "hsa_circ_0058122/miR-7974/IGFBP5 was proposed to be a key regulatory pathway for SONFH. DEX treatment upregulated hsa_circ_0058122 expression in HUVECs, which sponged miR-7974, thereby increasing IGFBP5 expression, the hsa_circ_0058122/miR-7974/IGFBP5 axis contributed to the Dex-mediated apoptosis. These findings may identify novel targets for SONFH molecular therap." 1 hsa_circ_0119412 overexpression promotes cervical cancer progression by targeting miR-217 to upregulate anterior gradient 2. hsa_circ_0119412 hsa_circ_PER2 circ_0119412 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circ_0119412 functioned as an oncogenic driver to promote the malignant development of cervical cancer by targeting the miR-217/AGR2 pathway. 1 Knockdown of circular RNA hsa_circ_0003307 inhibits synovial inflammation in ankylosing spondylitis by regulating the PI3K/AKT pathway. hsa_circ_0003307 hsa_circ_TALDO1 - DOID:7147 ankylosing spondylitis ankylosing spondylitis RT-qPCR up-regulated "The expression level of hsa_circ_0003307 was associated with inflammatory response, and it was revealed that hsa_circ_0003307 knockdown could reduce the inflammatory response of AS by regulating the PI3K/AKT pathway." 1 "Circular RNA sterile alpha motif domain containing 4A contributes to cell 5-fluorouracil resistance in colorectal cancer by regulating the miR-545-3p/6-phosphofructo-2-kinase/fructose-2,6-bisphosphataseisotype 3 axis." - hsa_circ_SAMD4A circSAMD4A DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "CircSAMD4A contributed to 5-Fu resistance of CRC cells partly through upregulating PFKFB3 expression by sponging miR-545-3p, providing a possible circRNA-targeted therapy for CRC." 1 Circ_0003146 upregulates SCARB1 expression by acting as a miR-1272 sponge to promote malignant behaviors of clear cell renal cell carcinoma. hsa_circ_0003146 - Circ_0003146 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated The regulation of circ_0003146 in ccRCC progression was achieved by upregulating SCARB1 in part. The current findings demonstrated that circ_0003146 contributed to the malignant progression of ccRCC via inducing SCARB1 upregulation by targeting miR-1272. 2 Circ-ZEB1 promotes PIK3CA expression by silencing miR-199a-3p and affects the proliferation and apoptosis of hepatocellular carcinoma. - hsa_circ_ZEB1 Circ-ZEB1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ-ZEB1 promoted the expression of PIK3CA by depleting miR-199a-3p, thereby affecting HCC proliferation and apoptosis." 1 CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype. - hsa_circ_ITGB6 CircITGB6 DOID:2394 ovarian cancer ovarian cancer RNA-seq up-regulated This study reveals a novel mechanism for platinum resistance in OC and demonstrates that circITGB6 may serve as a potential prognostic marker and a therapeutic target for patients with OC. 1 "Circ-OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR-558/THBS2 axis." - hsa_circ_OPHN1 Circ-OPHN1 DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated "Circ-OPHN1 inhibited trophoblast cell proliferation, migration, and invasion through mediating miR-558/THBS2 axis, providing a novel pathway for PE pathogenesis." 1 Circ_0002945 functions as a competing endogenous RNA to promote Abeta(25-35)-induced endoplasmic reticulum stress and apoptosis in SK-N-SH cells and human primary neurons. hsa_circ_0002945 - Circ_0002945 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated Our findings establish circ_0002945 as a crucial regulator of Abeta-induced neuron apoptosis and endoplasmic reticulum stress and uncover a novel circ_0002945/miR-431-5p/TNFAIP1 ceRNA network for the Abeta pathogenic pathway in AD. 2 hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis. - hsa_circ_ANKRD42 circANKRD42 DOID:850 lung disease lung fibrosis RT-qPCR up-regulated Our findings supported that circANKRD42 is a promising biomarker and a potential therapeutic target related to cytoskeleton tension for IPF treatment. 1 CircRNA circFADS2 is under-expressed in sepsis and protects lung cells from LPS-induced apoptosis by downregulating miR-133a. - hsa_circ_FADS2 circFADS2 DOID:0040085 bacterial sepsis sepsis RT-qPCR up-regulated CircFADS2 is under-expressed in sepsis and may protect lung cells from LPS-induced apoptosis by downregulating miR-133a. 2 "Circ_0001174 facilitates osteosarcoma cell proliferation, migration, and invasion by targeting the miR-186-5p/MACC1 axis." hsa_circ_0001174 - Circ_0001174 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated "Abnormally high expression of circ_0001174 may promote the proliferation, migration, and invasion of OS cells through up-regulating MACC1 by sponging miR-186-5p. These results provide insight into therapeutic targets for preventing and treating OS." 1 Integrative analysis reveals a lineage-specific circular RNA landscape for adipo-osteogenesis of human mesenchymal stem cells. - - circular RNA landscape DOID:0080001 bone disease adipo-osteogenesis "RT-qPCR, RNA-seq" dysregulated "Our integrative analysis reveals an accurate and generally applicable lineage-specific circRNA landscape for adipo-osteogenesis of MSCs and provides a potential therapeutic target, circ-CRLF1, for the treatment of skeleton-related disease." 1 Circ_0060731 mediated miR-21-5p-PDCD4/ESR1 pathway to induce apoptosis of placental trophoblasts in intrahepatic cholestasis of pregnancy. hsa_circ_0060731 - Circ_0060731 DOID:0070227 intrahepatic cholestasis of pregnancy Intrahepatic cholestasis of pregnancy RT-qPCR up-regulated Circ_0060731 mediated miR-21-5p-PDCD4/ESR1 pathway could induce apoptosis of placental trophoblasts in intrahepatic cholestasis of pregnancy. 1 Circ-TFF1 Promotes Breast Cancer Progression Through the miR-129-2-3p/IRAK1 Axis. hsa_circ_0061825 hsa_circ_TFF1 Circ-TFF1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ-TFF1 regulated the expression of IRAK1 by sponging miR-129-2-3p, thereby, promoting the development of BC. These data provided a novel targeted therapy for BC." 3 Circ_0000228 Promotes Cervical Cancer Progression via Regulating miR-337-3p /TGFBR1 Axis. hsa_circ_0000228 - Circ_0000228 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Circ_0000228_p-modulates_GFBR1_y targeting_iR-337-3p_o enhance CC cell proliferation, migration and invasion. Also,_irc_0000228_s a promising therapeutic target for the CC." 2 Circular RNA circDVL1 inhibits clear cell renal cell carcinoma progression through the miR-412-3p/PCDH7 axis. - hsa_circ_DVL1 circDVL1 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR down-regulated "Collectively, our results demonstrate that circDVL1 exerts tumor-suppressive function during ccRCC progression through circDVL1/miR-412-3p/PCDH7 axis, and suggest that circDVL1 could be a novel diagnostic and prognositc marker and therapeutic target for ccRCC." 1 CircATRNL1 and circZNF608 Inhibit Ovarian Cancer by Sequestering miR-152-5p and Encoding Protein. - hsa_circ_ATRNL1 CircATRNL1 DOID:2394 ovarian cancer ovarian cancer RNA-seq down-regulated "In conclusion, circATRNL1 and circZNF608 are two downregulated circRNAs in ovarian cancer and work as tumor suppressors. CircZNF608 may exert antitumor activity in ovarian cancer by binding miR-152-5p, and circATRNL1 may encode a 131 aa protein." 1 hsa_circ_0072309 Expression Profiling in Non-small-Cell Lung Carcinoma and Its Implications for Diagnosis and Prognosis. hsa_circ_0072309 hsa_circ_LIFR circ_0072309 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "hsa_circ_0072309 is lowly expressed in lung cancer patients and the survival rate of lowly expressed patients is significantly lower, a candidate marker with prognostic utility for the disease." 3 Hsa_circ_0001666 promotes non-small cell lung cancer migration and invasion through miR-1184/miR-548I/AGO1 axis. hsa_circ_0001666 hsa_circ_FAM120B circ_0001666 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Collectively, these findings demonstrated that circ0001666 could serve as an oncogene to promote the migration and invasion of NSCLC via a novel miR-1184/miR-548I/AGO1 axis, which might be a promising therapeutic target for NSCLC treatment." 2 "Circ_0062558 promotes growth, migration, and glutamine metabolism in triple-negative breast cancer by targeting the miR-876-3p/SLC1A5 axis." hsa_circ_0062558 - Circ_0062558 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_0062558 promoted TNBC progression by enhancing proliferation, survival, migration, invasion, and glutamine metabolism via miR-876-3p/SLC1A5 axis, which was helpful for understanding the carcinogenic roles of circ_0062558." 2 Circ_0075804 Regulates the Expression of LASP1 by Targeting miR-1287-5p and Thus Affects the Biological Process of Retinoblastoma. hsa_circ_0075804 - Circ_0075804 DOID:768 retinoblastoma Retinoblastoma RT-qPCR up-regulated "Circ_0075804 promotes LASP1 expression by targeting miR-1287-5p, thus acting as a contributor to RB carcinogenesis.HighlightsCirc_0075804 is overexpressed in RB.Circ_0075804 knockdown inhibits RB cell malignant phenotypes and tumor growth_n vivo.Circ_0075804 regulates RB cell behaviors by targeting miR-1287-5p.MiR-1287-5p affects RB cell behaviors by binding to LASP1.Circ_0075804 regulates LASP1 expression via targeting miR-1287-5p." 3 KLF2-induced circZKSCAN1 potentiates the tumorigenic properties of clear cell renal cell carcinoma by targeting the miR-1294/PIM1 axis. - hsa_circ_ZKSCAN1 circZKSCAN1 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated "we identified a novel circZKSCAN1/miR-1294/PIM1 axis was identified in RCC progression, showing that the expression of circZKSCAN1 expression in RCC cells was transcriptionally regulated by Kruppel-like factor 2. The results of our study may provide new insights for ccRCC basic research." 1 Hsa_circ_0037128 aggravates high glucose-induced podocytes injury in diabetic nephropathy through mediating miR-31-5p/KLF9. hsa_circ_0037128 hsa_circ_NPRL3 circ_0037128 DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "In summary, our data showed that hsa_circ_0037128 could promote HG-induced podocytes injury_ia_egulating miR-31-5p/KLF9 axis, showing that hsa_circ_0037128 might be a target for DN treatment." 2 Hsa_circ_0087352 promotes the inflammatory response of macrophages in abdominal aortic aneurysm by adsorbing hsa-miR-149-5p. hsa_circ_0087352 hsa_circ_UBQLN1 circ_0087352 DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm RNA-seq up-regulated "Overall, this study provides experimental evidence that hsa_circ_0087352 can be used as a new biomarker and therapeutic target for abdominal aortic aneurysm." 1 Hsa_circ_0017639 regulates cisplatin resistance and tumor growth via acting as a miR-1296-5p molecular sponge and modulating sine oculis homeobox 1 expression in non-small cell lung cancer. hsa_circ_0017639 hsa_circ_SFMBT2 circ_0017639 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "In conclusion, circ_0017639 conferred DDP resistance and promoted tumor growth via elevating SIX1 expression through sequestering miR-1296-5p in NSCLC, providing a new mechanism for understanding the chemoresistance and progression of NSCLC." 4 Circ_0064288 acts as an oncogene of hepatocellular carcinoma cells by inhibiting miR-335-5p expression and promoting ROCK1 expression. hsa_circ_0064288 - Circ_0064288 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ_0064288 facilitates HCC cell growth and migration by modulating the miR-335-5p/ROCK1 axis. 1 Autophagy-associated circRNA circATG7 facilitates autophagy and promotes pancreatic cancer progression. - hsa_circ_ATG7 circATG7 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "In conclusion, our results demonstrated that circATG7 accelerates PC progression via miR-766-5p/ATG7 and that HUR/ATG7 depends on autophagic flux. Thus, circATG7 may be a potential therapeutic target for PC." 1 CircEIF5 contributes to hyperproliferation and inflammation of keratinocytes in psoriasis via p-NFkappaB and p-STAT3 signalling pathway. hsa_circ_0033469 hsa_circ_EIF5 CircEIF5 DOID:8893 psoriasis psoriasis RT-qPCR up-regulated "through NF-kappaB and STAT3 signalling pathways, circEIF5 regulated the proliferation and chemokine secretion of HaCat cells and contributed to the pathogenesis of psoriasis, which might become a potent target for psoriasis treatment." 1 Circ_0014130 is involved in the drug sensitivity of colorectal cancer through miR-197-3p/PFKFB3 axis. hsa_circ_0014130 - Circ_0014130 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0014130 modulates 5-FU resistance in CRC by modulating the miR-197-3p/PFKFB3 axis, which is helpful for drug chemotherapy in CRC." 1 Circ_0048856 competes with ABCC1 for miR-193a-5p/miR-98-5p binding sites to promote the cisplatin resistance and tumorigenesis in lung cancer. hsa_circ_0048856 - Circ_0048856 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "circ_0048856 knockdown suppressed tumor growth and reduced DDP resistance in lung cancer by miR-193a-5p/ABCC1 or miR-98-5p/ABCC1 axis, indicating a novel strategy for efficient application of DDP in lung cancer." 1 Identification and characterization of circular RNAs in the A549 cells following Influenza A virus infection. hsa_circ_0082633 - circRNA_0082633 DOID:934 viral infectious disease Influenza A virus infection "RT-qPCR, microarray" up-regulated These data firstly provided the expression profile of circRNAs in PR8-infected A549 cells and shed new light on the pathogenesis research of IAV infection. Our findings also suggest that circRNA_0082633 served an important function in IAV infection. 1 Potential Role of circRNA-HIPK3/microRNA-124a Crosstalk in the Pathogenesis of Rheumatoid Arthritis. - hsa_circ_HIPK3 circRNA-HIPK3 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "Targeting circHIPK3 and microRNA-124a, and their downstream adaptor molecules, poses a new challenge for RA therapy." 1 circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury. mmu_circ_0001679 - circRNA_0001679 DOID:850 lung disease acute lung injury microarray up-regulated circ_0001679 knockdown inhibits sepsis-induced ALI progression through the miR-338-3p/DUSP16 axis. 1 Circ_0000064 promotes high glucose-induced renal tubular epithelial cells injury to facilitate diabetic nephropathy progression through miR-532-3p/ROCK1 axis. hsa_circ_0000064 - Circ_0000064 DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "circ_0000064 knockdown might alleviate HG-induced HK-2 cells injury via regulating the miR-532-3p/ROCK1 axis, which provided a new perspective for DN treatment." 3 Circular RNA circ_0002360 regulates the Taxol resistance and malignant behaviors of Taxol-resistant non-small cell lung cancer cells by microRNA-585-3p-dependent modulation of G protein regulated inducer of neurite outgrowth 1. hsa_circ_0002360 hsa_circ_RUNX1 circ_0002360 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our study demonstrated that silencing of circ_0002360 enhanced the Taxol sensitivity and suppressed the malignant behaviors of Taxol-resistant NSCLC cells by miR-585-3p/GPRIN1 axis, providing novel targets for improving the anti-tumor efficacy of Taxol in NSCLC." 1 Circ_0060531 knockdown ameliorates IL-22-induced keratinocyte damage by binding to miR-330-5p to decrease GAB1 expression. hsa_circ_0060531 - Circ_0060531 DOID:8893 psoriasis psoriasis RT-qPCR up-regulated "Circ_0060531 knockdown assuaged IL-22-induced keratinocyte dysfunction through miR-330-5p/GAB1 pathway, proving a novel target for the therapy of psoriasis." 1 Downregulation of Circular RNA circPSD3 Promotes Metastasis by Modulating FBXW7 Expression in Clear Cell Renal Cell Carcinoma. - hsa_circ_PSD3 - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, microarray" down-regulated circPSD3 inhibits tumor metastasis by repressing the miR-25-3p/FBXW7-EMT axis and might be developed as a potential diagnostic and therapeutic target for ccRCC. 1 Serum hsa_circ_0079480 is a novel prognostic marker for acute myeloid leukemia. hsa_circ_0079480 - hsa_circ_0079480 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated Levels of hsa_circ_0079480 in patient serum may offer value as a prognostic biomarker in AML. 1 Circ_0003340 downregulation mitigates esophageal squamous cell carcinoma progression by targeting miR-940/PRKAA1 axis. hsa_circ_0003340 - circ_0003340 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated Circ_0003340 downregulation mitigated esophageal squamous cell carcinoma progression by targeting miR-940/PRKAA1 axis. 1 Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis. - hsa_circ_VANGL1 - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "our results provide convincing evidence that circVANGL1 may exert oncogenic effects in PTC, partly via regulating the miR-194/ZEB1 axis." 1 [Effect of Circular RNA hsa_circ_0067582 on the Proliferation and Invasion Ability of Gastric Cancer Cells]. hsa_circ_0067582 hsa_circ_RASA2 circ_0067582 DOID:10534 stomach cancer gastric cancer RT-qPCR dysregulated "Oe-circ_0067582 can inhibit the proliferation and attenuate EMT process to reduce the invasion ability of AGS and SGC-7901 cells,which provides a new target for the treatment of GC." 3 Overexpressing circ_0000831 is sufficient to inhibit neuroinflammation and vertigo in cerebral ischemia through a miR-16-5p-dependent mechanism. hsa_circ_0000831 - circ_0000831 DOID:6713 cerebrovascular disease stroke RNA-seq down-regulated "these findings pinpoint the circ_0000831/miR-16-5p/AdipoR2 axis as an essential signaling pathway during ischemia stroke. Thus, the circRNA circ_0000831 may work as a possible target for novel treatment in patients with ischemic stroke." 2 Overexpressing circ_0000831 is sufficient to inhibit neuroinflammation and vertigo in cerebral ischemia through a miR-16-5p-dependent mechanism. hsa_circ_0000831 - circ_0000831 DOID:6713 cerebrovascular disease stroke RNA-seq down-regulated "these findings pinpoint the circ_0000831/miR-16-5p/AdipoR2 axis as an essential signaling pathway during ischemia stroke. Thus, the circRNA circ_0000831 may work as a possible target for novel treatment in patients with ischemic stroke." 2 Circular RNA circ-PLCD1 functions as a tumor suppressor in non-small cell lung cancer by inactivation of PI3K/AKT signaling pathway. - hsa_circ_PLCD1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RNA-seq down-regulated "our findings reveal the important tumor suppressive role of circ-PLCD1 in NSCLC, reactivation of this circRNA may be considered as a novel therapeutic avenue for patient with NSCLC." 1 Hsa_circ_0000081 promotes the function of gastric cancer through sponging hsa-miR-423-5p to influence 3-phosphoinositide-dependent kinase 1 expression. hsa_circ_0000081 hsa_circ_ROR1 circ_0000081 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "circRNA-0000081 promotes the function of GC through sponging hsa-miR-423-5p to influence PDPK1 expression, which has a promising therapeutic potential for treating patients with GC." 1 Hsa_circRNA_0017620 regulated cell progression of non-small-cell lung cancer via miR-520a-5p/KRT5 axis. hsa_circ_0017620 hsa_circ_SFMBT2 "circRNA_0017620, circ_0017620" DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "In this study, we found that hsa_circ_0017620 played an important role in NSCLC progression. Hsa_circ_0017620 regulated cell proliferation, invasion, and migration through targeting miR-520a-5p/KRT5 axis in NSCLC, providing a potential new target for the treatment and diagnosis of NSCLC." 4 ebv-circRPMS1 promotes the progression of EBV-associated gastric carcinoma via Sam68-dependent activation of METTL3. - ebv_circ_RPMS1 ebv-circRPMS1 DOID:5517 stomach carcinoma gastric carcinoma RT-qPCR up-regulated "ebv-circRPMS1, Sam68, and METTL3 might serve as therapeutic targets for EBVaGC." 1 "circ_0008797 attenuates non-small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR-301a-3p/SOCS2." hsa_circ_0008797 hsa_circ_GSK3B circ_0008797 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "circ_0008797 attenuates NSCLC proliferation, metastasis and aerobic glycolysis by sponging miR-301a-3p/SOCS2." 1 Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells. - - novel_circ_0004830 DOID:10690 mastitis mastitis "RT-qPCR, RNA-seq" down-regulated "Interestingly, novel_circ_0004830 and novel_circ_0003097 may both act as ceRNAs and bind to bta-miR-145. Chen et al. (2019) revealed that bta-miR-145 regulates Staphylococcus aureus (S. aureus)-induced mastitis in MAC-T cells by targeting the FSCN1 gene." 1 Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells. - - novel_circ_0003097 DOID:10690 mastitis mastitis RNA-seq down-regulated "Interestingly, novel_circ_0004830 and novel_circ_0003097 may both act as ceRNAs and bind to bta-miR-145. Chen et al. (2019) revealed that bta-miR-145 regulates Staphylococcus aureus (S. aureus)-induced mastitis in MAC-T cells by targeting the FSCN1 gene." 1 Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells. - - novel_circ_0005115 DOID:10690 mastitis mastitis "RT-qPCR, RNA-seq" down-regulated "Fig. 2._RT-PCR validation of DEcircRNAs. Relative expression levels of DEcircRNAs (novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, novel_circ_0001799, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136, and novel_circ_0001730) were verified by qRT-PCR, and the results indicate that the relative expression levels of novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, and novel_circ_0001799 were significantly down-regulated. On the contrary, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136 and novel_circ_0001730 expression levels were significantly up-regulated. The qRT-PCR results were consistent with the sequencing data." 1 Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells. - - novel_circ_0005861 DOID:10690 mastitis mastitis "RT-qPCR, RNA-seq" down-regulated "Fig. 2._RT-PCR validation of DEcircRNAs. Relative expression levels of DEcircRNAs (novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, novel_circ_0001799, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136, and novel_circ_0001730) were verified by qRT-PCR, and the results indicate that the relative expression levels of novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, and novel_circ_0001799 were significantly down-regulated. On the contrary, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136 and novel_circ_0001730 expression levels were significantly up-regulated. The qRT-PCR results were consistent with the sequencing data." 1 Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells. - - novel_circ_0004514 DOID:10690 mastitis mastitis "RT-qPCR, RNA-seq" down-regulated "Fig. 2._RT-PCR validation of DEcircRNAs. Relative expression levels of DEcircRNAs (novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, novel_circ_0001799, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136, and novel_circ_0001730) were verified by qRT-PCR, and the results indicate that the relative expression levels of novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, and novel_circ_0001799 were significantly down-regulated. On the contrary, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136 and novel_circ_0001730 expression levels were significantly up-regulated. The qRT-PCR results were consistent with the sequencing data." 1 Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells. - - novel_circ_0001799 DOID:10690 mastitis mastitis "RT-qPCR, RNA-seq" down-regulated "Fig. 2._RT-PCR validation of DEcircRNAs. Relative expression levels of DEcircRNAs (novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, novel_circ_0001799, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136, and novel_circ_0001730) were verified by qRT-PCR, and the results indicate that the relative expression levels of novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, and novel_circ_0001799 were significantly down-regulated. On the contrary, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136 and novel_circ_0001730 expression levels were significantly up-regulated. The qRT-PCR results were consistent with the sequencing data." 1 Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells. - - novel_circ_0001448 DOID:10690 mastitis mastitis "RT-qPCR, RNA-seq" up-regulated "Fig. 2._RT-PCR validation of DEcircRNAs. Relative expression levels of DEcircRNAs (novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, novel_circ_0001799, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136, and novel_circ_0001730) were verified by qRT-PCR, and the results indicate that the relative expression levels of novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, and novel_circ_0001799 were significantly down-regulated. On the contrary, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136 and novel_circ_0001730 expression levels were significantly up-regulated. The qRT-PCR results were consistent with the sequencing data." 1 Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells. - - novel_circ_0005856 DOID:10690 mastitis mastitis "RT-qPCR, RNA-seq" up-regulated "Fig. 2._RT-PCR validation of DEcircRNAs. Relative expression levels of DEcircRNAs (novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, novel_circ_0001799, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136, and novel_circ_0001730) were verified by qRT-PCR, and the results indicate that the relative expression levels of novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, and novel_circ_0001799 were significantly down-regulated. On the contrary, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136 and novel_circ_0001730 expression levels were significantly up-regulated. The qRT-PCR results were consistent with the sequencing data." 1 Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells. - - novel_circ_0001136 DOID:10690 mastitis mastitis "RT-qPCR, RNA-seq" up-regulated "Fig. 2._RT-PCR validation of DEcircRNAs. Relative expression levels of DEcircRNAs (novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, novel_circ_0001799, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136, and novel_circ_0001730) were verified by qRT-PCR, and the results indicate that the relative expression levels of novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, and novel_circ_0001799 were significantly down-regulated. On the contrary, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136 and novel_circ_0001730 expression levels were significantly up-regulated. The qRT-PCR results were consistent with the sequencing data." 1 Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells. - - novel_circ_0001730 DOID:10690 mastitis mastitis "RT-qPCR, RNA-seq" up-regulated "Fig. 2._RT-PCR validation of DEcircRNAs. Relative expression levels of DEcircRNAs (novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, novel_circ_0001799, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136, and novel_circ_0001730) were verified by qRT-PCR, and the results indicate that the relative expression levels of novel_circ_0005115, novel_circ_0005861, novel_circ_0004514, novel_circ_0004830, and novel_circ_0001799 were significantly down-regulated. On the contrary, novel_circ_0001448, novel_circ_0005856, novel_circ_0001136 and novel_circ_0001730 expression levels were significantly up-regulated. The qRT-PCR results were consistent with the sequencing data." 1 The N(6)-methyladenosine modification of circALG1 promotes the metastasis of colorectal cancer mediated by the miR-342-5p/PGF signalling pathway. - hsa_circ_ALG1 circALG1 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "M6A modification enhances the binding ability of circALG1 to miR-342-5p to promote the ceRNA function of circALG1, and circALG1 could be a potential therapeutic target in and a prognostic marker for CRC." 1 Circular RNA circ_0001006 aggravates cardiac hypertrophy via miR-214-3p/PAK6 axis. hsa_circ_0001006 rno_circ_RTN4 circ_0001006 DOID:114 heart disease heart disease "RT-qPCR, microarray" up-regulated Our data demonstrated that circRNA_0001006 exacerbates cardiac hypertrophy via suppressing miR-214-3p leading to enhanced PAK6 levels. 1 CircRNA_0078767 promotes osteosarcoma progression by increasing CDK14 expression through sponging microRNA-330-3p. hsa_circ_0078767 hsa_circ_FAM120B CircRNA_0078767 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circ_0078767 promotes the occurrence and development of osteosarcoma by upregulating CDK14 in a miR-330-3p-dependent manner. 3 Propofol Disrupts Clear Cell Renal Cell Carcinoma Tumorigenesis by Regulating circFBXW7/miR-942 Axis. - hsa_circ_FBXW7 circFBXW7 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated "Propofol suppressed the growth, migration, and invasion of ccRCC cells by regulating circFBXW7/miR-942 axis, suggesting a potential therapeutic strategy for the intervention of human ccRCC development." 2 CircOAS3 Regulates Keratinocyte Proliferation and Psoriatic Inflammation by Interacting with Hsc70 via the JNK/STAT3/NF-kappaB Signaling Pathway. - hsa_circ_OAS3 CircOAS3 DOID:8893 psoriasis psoriasis microarray up-regulated "the interaction between circOAS3 and Hsc70 mediates the proliferation and psoriatic inflammation of HaCaT and Ker-CT cells through the JNK/STAT3/NF-¦ĘB signaling pathway, suggesting that circOAS3 or Hsc70 may be a promising therapeutic target for psoriasis." 1 CircATIC inhibits esophageal carcinoma progression and promotes radiosensitivity by elevating RHCG through sponging miR-10-3p. - hsa_circ_ATIC CircATIC DOID:1107 esophageal carcinoma esophageal carcinoma RT-qPCR down-regulated Overexpression of circATIC hampered ESCA progression and promoted radiosensitivity depending on the regulation of miR-10b-3p and RHCG. 2 Circular RNA_0057209 Acts as ceRNA to Inhibit Thyroid Cancer Progression by Promoting the STK4-Mediated Hippo Pathway via Sponging MicroRNA-183. hsa_circ_0057209 hsa_circ_LOC100506866 circRNA_0057209 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR down-regulated "circRNA_0057209 may serve as a competing endogenous RNA of miR-183 to increase STK4 expression, thus inhibiting the development of thyroid cancer." 1 Identification of a Novel Survival-Related circRNA-miRNA-mRNA Regulatory Network Related to Immune Infiltration in Liver Hepatocellular Carcinoma. hsa_circ_0017264 hsa_circ_ADSS circ_0017264 DOID:684 hepatocellular carcinoma liver hepatocellular carcinoma RT-qPCR up-regulated the hsa_circ_0017264-hsa-miR-195-5p-CHEK1/CDC25A/FOXK1 network might provide novel insights into the potential mechanisms underlying LIHC onset and progression. 2 Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology. - hsa_circ_Satb1 Circ_Satb1 DOID:3328 temporal lobe epilepsy mesial temporal lobe epilepsy RNA-seq down-regulated our results identify a novel epilepsy-associated circRNA with disease-specific expression and previously unidentified cellular effects that are relevant for epileptogenesis. 1 hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis. hsa_circ_0077837 hsa_circ_EPB41L2 circ_0077837 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "Collectively, our findings validated that hsa_circ_0077837 served as a miR-1178-3p sponge by targeting APITD1 that alleviated NSCLC progression." 2 Circular RNA hsa_circ_0004543 Aggravates Cervical Cancer Development by Sponging MicroRNA hsa-miR-217 to Upregulate Hypoxia-Inducible Factor. hsa_circ_0004543 hsa_circ_NOL12 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated targeting the hsa_circ_0004543/hsa-miR-217/HIF-1alpha_xis might be a potential treatment approach for CC. 1 "Hsa_circ_0072008 regulates cell proliferation, migration, and invasion in cervical squamous cell carcinoma via miR-1305/helicase, lymphoid specific (HELLS) axis." hsa_circ_0072008 hsa_circ_MYO10 circ_0072008 DOID:3744 cervical squamous cell carcinoma cervical squamous cell carcinoma RT-qPCR up-regulated "circ_0072008 facilitated CESC cell proliferation, migration, and invasion through increasing HELLS expression by regulating miR-1305, which also offered an underlying targeted therapy for CESC treatment." 1 CircRNA hsa_circ_0018289 exerts an oncogenic role in cervical cancer progression through miR-1294/ICMT axis. hsa_circ_0018289 hsa_circ_SYT15 hsa_circ_0018289 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Hsa_circ_0018289 contributes to malignant development by regulating the miR-1294/ICMT axis, affording novel insight into CC therapy." 3 Hsa_circ_0007142 contributes to cisplatin resistance in esophageal squamous cell carcinoma via miR-494-3p/LASP1 axis. hsa_circ_0007142 hsa_circ_DOCK1 circ_0007142 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated Circ_0007142 improved DDP resistance of ESCC by upregulating LASP1 via sponging miR-494-3p. 1 Circ_0101802 Facilitates Colorectal Cancer Progression Depending on the Regulation of miR-665/DVL3 Signaling. hsa_circ_0101802 - Circ_0101802 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circ_0101802 contributed to CRC progression by targeting miR-665/DVL3 signaling. 3 [Mechanism of circZNF609 targeting miR-153 to regulate the proliferation and apoptosis of diffuse large B-cell lymphoma]. - hsa_circ_ZNF609 circZNF609 DOID:0050745 diffuse large B-cell lymphoma diffuse large b-cell lymphoma RT-qPCR up-regulated Down-regulation of circZNF609 inhibits the proliferation of diffuse large B-cell lymphoma OCI-LY19 cells and induces apoptosis by targeting miR-153. 1 Circular RNA hsa_circ_0011946 promotes the malignant process of salivary adenoid cystic carcinoma by downregulating miR-1205 expression. hsa_circ_0011946 hsa_circ_SCMH1 hsa_circ_0011946 DOID:4866 salivary gland adenoid cystic carcinoma salivary adenoid cystic carcinoma RT-qPCR up-regulated circRNA hsa_circ_0011946 was discovered to promote the malignant process of SACC by downregulating miR-1205 expression. 1 CircRHBDD1 augments metabolic rewiring and restricts immunotherapy efficacy via m(6)A modification in hepatocellular carcinoma. - hsa_circ_RHBDD1 CircRHBDD1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq up-regulated these findings illustrate the metabolic importance of the circRHBDD1/YTHDF1/PIK3R1 axis in HCC and show that suppression of circRHBDD1 may bolster the efficacy of anti-PD-1 therapy for HCC treatment. 2 Circular RNA circLAMA3 inhibits the proliferation of bladder cancer by directly binding an mRNA. - hsa_circ_LAMA3 circLAMA3 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "we report a potential novel regulatory mechanism via which a circRNA directly binds an mRNA and thereby regulates its fate. Moreover, circLAMA3 significantly affects the progression of bladder cancer and has potential as a diagnostic biomarker and therapeutic target for bladder cancer." 1 CircESRP1 enhances metastasis and epithelial-mesenchymal transition in endometrial cancer via the miR-874-3p/CPEB4 axis. - hsa_circ_ESRP1 CircESRP1 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated CircESRP1 can interact with miR-874-3p to regulate EMT in endometrial cancer via the miR-874-3p/CPEB4 axis. CircESRP1 may serve as a promising therapeutic target for endometrial cancer. 1 High-dose-androgen-induced autophagic cell death to suppress the Enzalutamide-resistant prostate cancer growth via altering the circRNA-BCL2/miRNA-198/AMBRA1 signaling. - hsa_circ_BCL2 circRNA-BCL2 DOID:0080909 castration-resistant prostate carcinoma castration-resistant prostate cancer RT-qPCR down-regulated "Together, these in vitro and in vivo data provide new insights for understanding the mechanisms underlying high-dose-DHT suppression of the EnzR CRPC cell growth, supporting a potential therapy using high-dose-androgens to suppress CRPC progression in the future." 1 CircRBM33 downregulation inhibits hypoxia-induced glycolysis and promotes apoptosis of breast cancer cells via a microRNA-542-3p/HIF-1alpha axis. - hsa_circ_RBM33 CircRBM33 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "downregulating circRBM33 suppresses miR-542-3p-targeted HIF-1alpha expression, resulting in the inhibition of glycolysis and proliferation and the promotion of BCa cells apoptosis." 1 Identification and Characterization of the Roles of circCASP9 in Gastric Cancer Based on a circRNA-miRNA-mRNA Regulatory Network. - hsa_circ_CASP9 circCASP9 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated circCASP9 can regulate the growth and metastasis of GC via the miR-589-5p/KANK1 axis. The circCASP9/miR-589-5p/KANK1 axis might provide crucial insights for investigating the occurrence and development of GC. 1 Circular RNA circLMO1 Suppresses Cervical Cancer Growth and Metastasis by Triggering miR-4291/ACSL4-Mediated Ferroptosis. - hsa_circ_LMO1 CircLMO1 DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" down-regulated "CircLMO1 acted as a tumor suppressor of cervical cancer by regulating miR-4291/ACSL4-mediated ferroptosis, and could be a promising biomarker for the clinical management of cervical cancer." 1 Circ_0058063 contributes to cisplatin-resistance of bladder cancer cells by upregulating B2M through acting as RNA sponges for miR-335-5p. hsa_circ_0058063 - Circ_0058063 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Our results demonstrated that circ_0058063 contributed to CDDP resistance of bladder cancer cells via sponging miR-335-5p, and B2M might be the downstream effector gene. This study firstly evidenced that targeting circ_0058063 might be an effective strategy to improve CDDP-sensitivity in BC." 3 Identification of potentially functional circular RNAs hsa_circ_0070934 and hsa_circ_0004315 as prognostic factors of hepatocellular carcinoma by integrated bioinformatics analysis. hsa_circ_0070934 hsa_circ_LARP1B circLMO1 DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" down-regulated "CircLMO1 acted as a tumor suppressor of cervical cancer by regulating miR-4291/ACSL4-mediated ferroptosis, and could be a promising biomarker for the clinical management of cervical cancer." 1 Circ_0001093 promotes glutamine metabolism and cancer progression of esophageal squamous cell carcinoma by targeting miR-579-3p/glutaminase axis. hsa_circ_0001093 - Circ_0001093 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "first provides evidence that the circ_0001093/miR-579-3p/GLS regulatory network can affect glutamine metabolism and malignant phenotype of ESCC, which can further impact ESCC progression." 1 Circ_0005526 contributes to interleukin-1beta-induced chondrocyte injury in osteoarthritis via upregulating transcription factor 4 by interacting with miR-142-5p. hsa_circ_0005526 - Circ_0005526 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated These results unraveled that circ_0005526 promoted IL-1beta-induced chondrocyte injury in OA via suppressing miR-142-5p binding to TCF4. 1 CircFOXK2 enhances tumorigenesis and immune evasion in non-small cell lung cancer by miR-485-5p/PD-L1 axis. - hsa_circ_FOXK2 CircFOXK2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircFOXK2 sponged miR-485-5p to stimulate PD-L1 and expedited NSCLC development. 2 Dexmedetomidine disrupts esophagus cancer tumorigenesis by modulating circ_0003340/miR-198/HMGA2 axis. hsa_circ_0003340 - circ_0003340 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "DEX constrained cell carcinogenesis by regulating circ_0003340/miR-198/HMGA2 axis in esophagus cancer, providing an effective clinical implication for preventing the development of the esophagus cancer by the DEX." 3 Circ_0058063 promotes progression of thyroid cancer by sponging miR-330-3p/SDC4 axis. hsa_circ_0058063 - Circ_0058063 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated circ_0058063 can act as a carcinogen in cases with TC via the miR-330-3p/SDC4 axis. 1 Circ_0043947 contributes to interleukin 1beta-induced injury in chondrocytes by sponging miR-671-5p to up-regulate RTN3 expression in osteoarthritis pathology. hsa_circ_0043947 - Circ_0043947 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Circ_0043947 silencing alleviated IL-1beta-induced injury in chondrocytes by targeting miR-671-5p/RTN3 axis. 1 Knockdown of circ_0055412 promotes cisplatin sensitivity of glioma cells through modulation of CAPG and Wnt/beta-catenin signaling pathway. hsa_circ_0055412 - circ_0055412 DOID:0060108 brain glioma glioma RT-qPCR up-regulated Circ_0055412 contributed to cisplatin resistance of glioma cells via stabilizing CAPG mRNA and modulating Wnt/beta-catenin signaling pathway. This finding might provide novel information for the treatment of glioma. 1 Cancer-released exosomal circular RNA circ_0008717 promotes cell tumorigenicity through microRNA-1287-5p/P21-activated kinase 2 (PAK2) axis in non-small cell lung cancer. hsa_circ_0008717 - circ_0008717 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ_0008717 was incorporated into exosomes in NSCLC cells. Circ_0008717 knockdown inhibited NSCLC tumorigenesis via miR-1287-5p/PAK2 axis, and the extracellular circulating circ_0008717 was transferred through incorporation in exosomes." 2 Regulation of circADAMTS6-miR-324-5p-PIK3R3 ceRNA pathway may be a novel mechanism of IL-1beta-induced osteoarthritic chondrocytes. - hsa_circ_ADAMTS6 circADAMTS6 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated CircADAMTS6-miR-324-5p-PIK3R3 axis might participate in IL-1beta-induced HCs dysfunction via competing endogenous RNA mechanism and the PI3K/AKT/mTOR signaling pathway. 2 Circ_RPPH1 regulates glioma cell malignancy by binding to miR-627-5p/miR-663a to induce SDC1 expression. - hsa_circ_RPPH1 Circ_RPPH1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Circ_RPPH1 knockdown inhibited glioma tumorigenesis by downregulating SDC1 by binding to miR-627-5p/miR-663a, showing that circ_RPPH1 might be an effective therapeutic target for glioma." 2 Circular RNA circ_0047744 suppresses the metastasis of pancreatic ductal adenocarcinoma by regulating the miR-21/SOCS5 axis. hsa_circ_0047744 - circ_0047744 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR down-regulated "Circ_0047744 acts as an anti-oncogene to inhibit PDAC metastasis by regulating the miR-21/SOCS5 axis, indicating that circ_0047744 may be a potential novel therapeutic target for PDAC patients." 1 Circ_SAR1A regulates the malignant behavior of lung cancer cells via the miR-21-5p/TXNIP axis. - hsa_circ_SAR1A Circ_SAR1A DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "circ_SAR1A is a critical negative regulator of lung carcinogenesis. circ_SAR1A/miR-21-5p/TXNIP attenuation inhibited lung cancer progression, presenting an ideal diagnostic and a potential therapeutic target." 1 Biological and clinical implications of hsa_circ_0086720 in gastric cancer and its clinical application. hsa_circ_0086720 hsa_circ_UBAP2 circ_0086720 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Hsa_circ_0086720 is a novel biomarker for screening early GC and predicting the prognosis of advanced-stage patients. 2 CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA- and RBP-dependent manner. - hsa_circ_THBS1 CircTHBS1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our research identified circTHBS1 as an oncogenic circRNA that enhances GC malignancy by elevating INHBA expression, providing new insight and a feasible target for the diagnosis and treatment of GC." 2 CircRNA circ_0043533 facilitates cell growth in polycystic ovary syndrome by targeting miR-1179. hsa_circ_0043533 - circ_0043533 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RT-qPCR up-regulated Circ_0043533 knockdown restrained the malignant progression of PCOS via targeting miR-1179. Our data suggested that circ_0043533 would serve as a novel therapeutic target for PCOS. 2 CircNR3C1 Alleviates Gastric Cancer Development by Inactivating AKT/mTOR. - hsa_circ_NR3C1 CircNR3C1 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated circNR3C1 inhibits GC to proliferate and migrate by inactivating the AKT/mTOR signaling. It is also closely linked to GC metastasis. 1 Circ_0078767 Inhibits the Progression of Non-Small-Cell Lung Cancer by Regulating the GPX3 Expression by Adsorbing miR-665. hsa_circ_0078767 - Circ_0078767 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "Circ_0078767 silencing promotes proliferation, migration, invasion, and glycolysis of NSCLC cells by regulating the miR-665/GPX3 axis, suggesting that circ_0078767/miR-665/GPX3 axis may be a potential regulatory mechanism for the treatment of NSCLC." 1 Circ_0041732 regulates tumor properties of triple-negative breast cancer cells by the miR-149-5p/FGF5 pathway. hsa_circ_0041732 - Circ_0041732 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0041732 silencing suppressed TNBC cell tumor properties by decreasingFGF5expression through miR-149-5p. This finding demonstrated that circ_0041732 had the potential as a therapeutic target for TNBC. 2 CircRAPGEF5 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma through the miR-1236-3p/ZEB1 Axis and Serves as a Potential Biomarker. - hsa_circ_RAPGEF5 CircRAPGEF5 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated exosomal circRAPGEF5 could promote the proliferation and metastasis of LAD via the miR-1236-3p/ZEB1 axis and serum exosomal circRAPGEF5 may serve as a promising biomarker for LAD. 1 Circular RNA dehydrodolichyl diphosphate synthase facilitated triple-negative breast cancer progression via miR-362-3p/DDX5 axis. - hsa_circ_DHDDS circDHDDS DOID:1612 breast cancer breast cancer RT-qPCR up-regulated CircDHDDS expedited TNBC by swelling DDX5 via adapting miR-362-3p. 1 circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p. - hsa_circ_SYPL1 circSYPL1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "On a mechanistic level, circSYPL1 can interact with miR-506-3p in a competitive manner to upregulate EZH2, hence increasing the aggressiveness of tumors." 1 CircRNA6783 Inhibits Cell Proliferation and Promotes Apoptosis in Lung Adenocarcinoma. - - CircRNA6783 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated CircRNA6783 was upregulated in LA PWB. In vitro assessment demonstrated that circRNA6783 could act as a potential biomarker for LA diagnosis. 1 CircRbms1 knockdown alleviates hypoxia-induced cardiomyocyte injury via regulating the miR-742-3p/FOXO1 axis. - hsa_circ_Rbms1 CircRbms1 DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated "CircRbms1 regulated the miR-742-3p/FOXO1 axis to mediate hypoxia-induced cardiomyocyte injury, suggesting that circRbms1 might be an effective target for MI treatment." 1 "Hsa_circ_0001017 promotes cell proliferation, migration and invasion in osteosarcoma by sponging miR-145-5p." hsa_circ_0001017 hsa_circ_XPO1 circ_0001017 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "In conclusion, our study suggested that circ_0001017 may be a novel oncogenic factor during the progression and development of OS by targeting miR-145-5p." 2 LPS-inducible circAtp9b is highly expressed in osteoporosis and promotes the apoptosis of osteoblasts by reducing the formation of mature miR-17-92a. - hsa_circ_Atp9b circAtp9b DOID:11476 osteoporosis osteoporosis RT-qPCR up-regulated CircAtp9b is LPS-inducible and upregulation of circAtp9b in OS promotes the apoptosis of osteoblasts by reducing the formation of mature miR-17-92a. 1 Circular RNA hsa_circ_0000848 Regulates Cardiomyocyte Proliferation and Apoptosis Under Hypoxia via Recruiting ELAVL1 and Stabilizing SMAD7 mRNA. hsa_circ_0000848 hsa_circ_SMAD7 - DOID:5844 myocardial infarction myocardial Infarction RT-qPCR down-regulated "Our research was the first in the field to confirm that the hsa_circ_0000848/ ELAV-like RNA-binding protein 1/SMAD family member 7 axis could affect the development of cardiomyocyte cells cultured under hypoxia, indicating that hsa_circ_0000848 might function as a novel biomarker in cells under hypoxia thus laying the groundwork for future study on myocardial infarction." 1 "circ_0006089 promotes gastric cancer growth, metastasis, glycolysis, and angiogenesis by regulating miR-361-3p/TGFB1." hsa_circ_0006089 - circ_0006089 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "the circ_0006089/miR-361-3p/TGFB1 axis contributed to GC progression, confirming that circ_0006089 might be a potential therapeutic target for GC." 4 "Circular RNA PLCE1 promotes epithelial mesenchymal transformation, glycolysis in colorectal cancer and M2 polarization of tumor-associated macrophages." - hsa_circ_PLCE1 circPLCE1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "It was assured that refrained circPCLE1 constrained CRC tumor growth, EMT and TAM M2 polarization. In brief, circPCLE1 expedites EMT, glycolysis in CRC and TAM M2 polarization via modulating the miR-485-5p/ACTG1 axis, and is supposed to be a latent molecular target for CRC therapy later." 2 Hypoxia-induced circWSB1 promotes breast cancer progression through destabilizing p53 by interacting with USP10. - hsa_circ_WSB1 circWSB1 DOID:1612 breast cancer breast cancer microarray up-regulated "disclose a novel mechanism that hypoxia-inducible circWSB1 could interact with USP10 to attenuate USP10 mediated p53 stabilization and promote the progression of BC, providing an alternative prognostic biomarker and therapeutic target for BC." 1 The Circular RNA circSKA3 Facilitates the Malignant Biological Behaviors of Medulloblastoma via miR-520 h/CDK6 Pathway. - hsa_circ_SKA3 circSKA3 DOID:0050902 medulloblastoma medulloblastoma RT-qPCR up-regulated Rescue experiments revealed that miR-520 h down-modulation or CDK6 overexpression remarkably counteracted the inhibitory effect of circSKA3 knockdown on Daoy cells. circSKA3 facilitates medulloblastoma progression through miR-520 h/CDK6. 4 Circ_0088036 facilitates the proliferation and inflammation and inhibits the apoptosis of fibroblast-like synoviocytes through targeting miR-326/FZD4 axis in rheumatoid arthritis. hsa_circ_0088036 - Circ_0088036 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated Circ_0088036 contributed to TNF-alpha-induced RA progression partly by targeting miR-326/FZD4 signalling. 3 Knockdown of circ-PRKCH alleviates IL-1beta-treated chondrocyte cell phenotypic changes through modulating miR-502-5p/ADAMTS5 axis. - hsa_circ_PRKCH circ-PRKCH DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Circ-PRKCH contributed to IL-1beta-treated cell phenotypic changes in chondrocytesviamodulating miR-502-5p/ADAMTS5 pathway, which might provide a promising biomarker for OA treatment." 3 CircRNA circBACH1 facilitates hepatitis B virus replication and hepatoma development by regulating the miR-200a-3p/MAP3K2 axis. - hsa_circ_BACH1 circBACH1 DOID:684 hepatocellular carcinoma hepatoma RT-qPCR up-regulated "CircBACH1 knockdown had inhibitory effects on HBV replication and hepatoma progression, at least partly by modulating the miR-200a-3p/MAP3K2 axis." 3 Knockdown of circ_CDYL Contributes to Inhibit Angiotensin II-Induced Podocytes Apoptosis in Membranous Nephropathy via the miR-149-5p/TNFSF11 Pathway. - hsa_circ_CDYL circ_CDYL DOID:557 kidney disease membranous nephropathy RT-qPCR up-regulated "circ_CDYL specifically targeted miR-149-5p/TNFSF11 pathway to regulate Ang II-induced apoptosis in podocytes, which might be useful diagnostic biomarkers in MN." 1 Circular RNA has Circ 001372-Reduced Inflammation in Ovalbumin-Induced Asthma Through Sirt1/NFAT5 Signaling Pathway by miRNA-128-3p. - - circ 001372 DOID:3347 osteosarcoma ovalbumin-induced asthma RT-qPCR down-regulated the serum of circ 001372 against inflammation in ovalbumin-induced asthma through Sirt1/NFAT5 by miRNA-128-3p. 1 Adipose-Derived Stem Cells-Derived Exosomes with High Amounts of Circ_0001747 Alleviate Hypoxia/Reoxygenation-Induced Injury in Myocardial Cells by Targeting MiR-199b-3p/MCL1 Axis. hsa_circ_0001747 - circ_0001747 DOID:5844 myocardial infarction acute myocardial infarction RT-qPCR up-regulated ADSCs-derived exosomes with high amounts of circ_0001747 attenuated H/R-induced HL-1 dysfunction partly by targeting miR-199b-3p/MCL1 signaling. 1 Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis. hsa_circ_0007967 hsa_circ_ATF2 circ_0007967 DOID:10534 stomach cancer gastric cancer RNA-seq up-regulated hsa_circ_0007967 is a promising biomarker for gastric cancer diagnosis and a potential molecule for gastric cancer treatment. 1 Circ_0000263 facilitates the proliferation and inhibits the apoptosis of cervical cancer depending on the regulation of miR-1179/ABL2 axis. hsa_circ_0000263 - Circ_0000263 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Circ_0000263 exerted an oncogene role in CC, which suggested that circ_0000263 might be a promising therapeutic target for CC." 2 Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p. - hsa_circ_ZFR Circ_ZFR DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_ZFR might act as a miRNA sponge for miR-223-3p to regulate FABP7, thereby promoting proliferation, migration, invasion, and EMT of BC cells, and inhibiting cell apoptosis." 2 circRNA_101277 Influences Cisplatin Resistance of Colorectal Cancer Cells by Modulating the miR-370/IL-6 Axis. - - circRNA_101277 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated highlight circRNA_101277 as a novel driver of CRC cell cisplatin resistance that functions by sequestering miR-370 and thereby enhancing IL-6 expression. These findings suggest that this circRNA_101277/miR-370/IL-6 axis may represent a critical axis of chemoresistance in CRC that can be targeted to diagnose and/or treat this cancer. 1 Circ_0008717 promotes renal cell carcinoma progression by upregulating FBXO17 via targeting miR-217. hsa_circ_0008717 - Circ_0008717 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "Circ_0008717 aggravated the progression of RCC by activating FBXO17 through targeting miR-217, which provided a novel mechanism for circ_0008717 to participate in RCC progression." 1 "Circular RNA LONP2 regulates proliferation, invasion, and apoptosis of bladder cancer cells by sponging microRNA-584-5p." - hsa_circ_LONP2 circLONP2 DOID:11054 urinary bladder cancer bladder cancer RNA-seq up-regulated "circLONP2 plays an oncogenic function in BC by regulating miR-584-5p/YAP1 axis, and its interaction with miR-584-5p provides a potential strategy to target BC." 1 "Circular RNA circ_0130438 suppresses TNF-alpha-induced proliferation, migration, invasion and inflammation in human fibroblast-like MH7A synoviocytes by regulating miR-130a-3p/KLF9 axis." hsa_circ_0130438 - circ_0130438 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR down-regulated "the elevated expression of circRNA circ_0130438 suppresses TNF-alpha-induced migration, proliferation and pro-inflammatory cytokines (IL-1beta, IL-6 and IL-8) production of human MH7A cells by enhancing KLF9 expression by operating as a ceRNA for miR-130a-3p." 2 circ0125803 facilitates tumor progression by sponging miR-197-5p and upregulating E2F1 in neuroblastoma. hsa_circ_0125803 - circ0125803 DOID:769 neuroblastoma neuroblastoma microarray up-regulated the biological function of the circ0125803-miR-197-5p-E2F1 axis in neuroblastoma metastasis and growth. 1 Circular RNA TLK1 Exerts Oncogenic Functions in Hepatocellular Carcinoma by Acting as a ceRNA of miR-138-5p. - hsa_circ_TLK1 circ-TLK1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circ-TLK1 functions as an oncogene in HCC progression partly through acting as a ceRNA of miR-138-5p, which may be a promising target for HCC therapy." 1 Circular RNA circStag1 promotes bone regeneration by interacting with HuR. - hsa_circ_Stag1 circStag1 DOID:11476 osteoporosis postmenopausal osteoporosis "RT-qPCR, RNA-seq" down-regulated "circStag1 plays a pivotal role in promoting the regeneration of bone tissue via HuR/Wnt signaling, which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis." 1 circ3323 Motivates Host Gene to Promote the Aggressiveness of Bladder Cancer. - - circ3323 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circ3323 modulates metastasis of BCa through miR-186-5p/APP axis and may serve as a promising prognostic biomarker for BCa, which provides novel insights into treatment of BCa." 1 CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFkappaB signaling pathway. - hsa_circ_ZDBF2 CircZDBF2 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "CircZDBF2 up-regulated RNF145 expression by sponging miR-362-5p and miR-500b-5p and recruiting CEBPB, thereby promoting OSCC progression via NF¦ĘB signaling pathway. The findings recommend circZDBF2 as a probable therapeutic target for OSCC." 1 "Circ_0047921 acts as the sponge of miR-1287-5p to stimulate lung cancer progression by regulating proliferation, migration, invasion, and glycolysis of lung cancer cells." hsa_circ_0047921 - Circ_0047921 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "Circ_0047921 was overexpressed in lung cancer, and circ_0047921 targeted miR-1287-5p to modulate LARP1 expression, thereby facilitating the development of lung cancer." 1 CircSCAP interacts with SF3A3 to inhibit the malignance of non-small cell lung cancer by activating p53 signaling. hsa_circ_0065214 hsa_circ_SCAP CircSCAP DOID:3908 lung non-small cell carcinoma non-small cell lung cancer microarray down-regulated These findings illustrate a novel circSCAP/SF3A3/p53 signaling axis involved in suppressing the malignance of NSCLC and provide a promising target for NSCLC prognosis prediction and treatment. 2 [Overexpression of circ_LARP4 inhibits the proliferation and migration of MCF-7 human breast cancer cells and its mechanism]. - hsa_circ_LARP4 circ_LARP4 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Overexpression of circ_LARP4 inhibits the proliferation, invasion and stem cell-like characteristics of MCF-7 breast cancer cells, and down-regulates the levels of iNOS and IL-1beta." 2 Circular RNA circGSE1 promotes angiogenesis in ageing mice by targeting the miR-323-5p/NRP1 axis. - hsa_circ_GSE1 circGSE1 DOID:1287 cardiovascular system disease cardiovascular disease RNA-seq down-regulated "circGSE1 may act through the miR-323-5p/NRP1 axis and promote endothelial angiogenesis in mice. Finally, the circGSE1/miR-323-5p/NRP1 axis could serve as a potential and promising therapeutic target for angiogenesis during ageing." 1 Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer disease mice model. - hsa_circ_Epc1 circ-Epc1 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated hypoxic pretreatment of ADSC exosomes improved cognition by delivery of circ-Epc1 and by shifting microglial M1/M2 polarization in an AD mouse model. 1 Circular RNA MTCL1 promotes advanced laryngeal squamous cell carcinoma progression by inhibiting C1QBP ubiquitin degradation and mediating beta-catenin activation. - hsa_circ_MTCL1 circMTCL1 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "A novel circMTCL1-C1QBP-beta-catenin signaling axis involving in LSCC tumorigenesis and progression, which shed new light on circRNAs-ubiquitous acidic glycoprotein mediated ubiquitin degradation and provided strategies and targets in the therapeutic intervention of LSCC." 1 A novel peptide encoded by N6-methyladenosine modified circMAP3K4 prevents apoptosis in hepatocellular carcinoma. - hsa_circ_MAP3K4 circMAP3K4 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircMAP3K4 is a highly expressed circRNA in HCC. Driven by m6A modification, circMAP3K4 encoded circMAP3K4-455aa, protected HCC cells from cisplatin exposure, and predicted worse prognosis of HCC patients. Targeting circMAP3K4-455aa may provide a new therapeutic strategy for HCC patients, especially for those with chemoresistance. CircMAP3K4 is a highly expressed circRNA in HCC. Driven by m6A modification, IGF2BP1 facilitates circMAP3K4 peptide translation, then the circMAP3K4 peptide inhibits AIF cleavage and nuclear distribution, preventing HCC cells from cell death under stress and promoting HCC progression." 1 CircRPAP2 regulates the alternative splicing of PTK2 by binding to SRSF1 in breast cancer. hsa_circ_000091 hsa_circ_RPAP2 CircRPAP2 DOID:162 cancer malignant tumor RT-qPCR down-regulated "circRPAP2 plays a tumor suppressor role and may serve as a biomarker in breast cancer. In addition, the identification of the circRPAP2/SRSF1/PTK2 axis provides new insights into the pathogenesis of breast cancer and highlights a novel target for the development of oncotherapeutics." 1 "Circular RNA circPSAP functions as an efficient miR-331-3p sponge to regulate proliferation, apoptosis and bortezomib sensitivity of human multiple myeloma cells by upregulating HDAC4." - hsa_circ_PSAP CircPSAP DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated "Our findings highlight a novel mechanism, in which circPSAP functions as a miR-331-3p sponge to impact MM cell proliferation, apoptosis and BTZ sensitivity by regulating HDAC4 expression." 1 Circular RNA circASPM promotes the progression of glioblastoma by acting as a competing endogenous RNA to regulate miR-130b-3p/E2F1 axis. - hsa_circ_ASPM CircASPM DOID:3073 brain glioblastoma multiforme glioblastoma multiforme RT-qPCR up-regulated "CircASPM can promote GBM progression via regulating miR-130b-3p/E2F1 axis, suggesting that circAPSM could provide an effective biomarker for GBM diagnosis and prognostic evaluation and possibly being used for molecular targeted therapy." 1 circ_0000567/miR-421/TMEM100 Axis Promotes the Migration and Invasion of Lung Adenocarcinoma and Is Associated with Prognosis. hsa_circ_0000567 - circ_0000567 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated miR-421 promotes the migration and invasion of lung adenocarcinoma via circ_0000567/miR-421/TMEM100signaling and could be a prognostic biomarker for LUAD. 2 "circSSU72 Promotes Cell Proliferation, Migration and Invasion of Papillary Thyroid Carcinoma Cells by Targeting miR-451a/S1PR2 Axis." - hsa_circ_SSU72 circSSU72 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "circSSU72 (hsa_circ_0009294)/miR-451a/S1PR2 axis may promote cell proliferation, migration, and invasion in PTC. Thus, circSSU72 may serve as a potential biomarker and therapeutic target for PTC." 1 Hsa_circ_0060927 participates in the regulation of Caudatin on colorectal cancer malignant progression by sponging miR-421/miR-195-5p. hsa_circ_0060927 hsa_circ_CYP24A1 circ_0060927 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Caudatin inhibited CRC cell malignancy through the hsa_circ_0060927/miR-421/miR-195-5p pathway, which provided a potential therapeutic agent for CRC." 2 Hsa_circ_0058129 regulates papillary thyroid cancer development via miR-873-5p/follistatin-like 1 axis. hsa_circ_0058129 hsa_circ_FN1 circ_0058129 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated Circ_0058129 expedited PTC progression through the miR-873-5p/FSTL1 pathway. 1 Circ_0005576 Exerts an Oncogenic Role in Cervical Cancer via miR-1305-Dependent Regulation of PAIP1. hsa_circ_0005576 - Circ_0005576 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Circ_0005576 depletion suppressed tumor development in CC by regulating the miR-1305/PAIP1 axis, suggesting that circ_0005576 might be a potential biomarker for CC treatment." 2 "Circular RNA circ_0061140 accelerates hypoxia-induced glycolysis, migration, and invasion in lung adenocarcinoma through the microRNA-653/hexokinase 2 (HK2) axis." hsa_circ_0061140 - circ_0061140 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "circ_0061140 accelerated hypoxia-triggered glycolysis, migration and invasion in LUAD cells via downregulating miR-653 and increasing HK2 expression." 1 Circ_0007841 knockdown confers cisplatin sensitivity to ovarian cancer cells by down-regulation of NFIB expression in a miR-532-5p-dependent manner. hsa_circ_0007841 - Circ_0007841 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Circ_0007841 conferred DDP resistance to DDP-resistant OC cells through the miR-532-5p/NFIB axis, suggesting the potential of circ_0007841 as a therapeutic target for OC." 1 Hsa_circ_0030042 Facilitates the Proliferation and Migration of Vascular Smooth Muscle Cells via the miR-514a-3p/FOXO1 Axis. hsa_circ_0030042 hsa_circ_FOXO1 circ_0030042 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Our study stated the vital role of the hsa_circ_0030042/miR-514a-3p/FOXO1 axis and provides a profound understanding about the circRNA in AS. 2 Circ_0036412 affects the proliferation and cell cycle of hepatocellular carcinoma via hedgehog signaling pathway. hsa_circ_0036412 - Circ_0036412 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ_0036412 affects the proliferation and cell cycle of HCC via Hedgehog signaling pathway. It offers an insight into the targeted therapies of HCC. 1 Circular RNA_0006014 promotes breast cancer progression through sponging miR-885-3p to regulate NTRK2 and PIK3/AKT pathway. hsa_circ_0006014 hsa_circ_ILKAP circ_0006014 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated hsa_circ_0006014 promotes breast cancer progression by sponging miR-885-3p to regulate the NTRK2/PIK3CA/AKT axis. 1 "CircTCF25 serves as a sponge for miR-206 to support proliferation, migration, and invasion of glioma via the Jak2/p-Stat3/CypB axis." - hsa_circ_TCF25 CircTCF25 DOID:0060108 brain glioma glioma RT-qPCR down-regulated "the circTCF25/miR-206/CypB axis plays a vital role in glioma progression, migration, invasion, and tumorigenesis." 1 CircLDLR Modulates the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Coronary Artery Disease Through miR-26-5p/KDM6A Axis. - hsa_circ_LDLR CircLDLR DOID:3393 coronary artery disease coronary artery disease RT-qPCR down-regulated CircLDLR modulates the proliferation and apoptosis of VSMCs through miR-26-5p/KDM6A axis. 1 High Expression of Circular RNA-Mitochondrial tRNA Translation Optimization 1 Assists the Diagnosis of High-Risk Human Papillomavirus Infection in Cervical Cancer. - hsa_circ_MTO1 circMTO1 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Serum circMTO1 is upregulated in HR-HPV-positive CC patients and has a diagnostic value for HR-HPV infection in CC. 2 Sevoflurane inhibits the malignant phenotypes of glioma through regulating miR-146b-5p/NFIB axis. - hsa_circ_VCAN Circ_VCAN DOID:0060108 brain glioma glioma RT-qPCR down-regulated "Sevoflurane alleviated proliferation, migration and invasion, but enhanced apoptosis of glioma cells through regulating circ_VCAN/miR-146b-5p/NFIB axis." 3 MM-associated circular RNA downregulates microRNA-19a through methylation to suppress proliferation of pancreatic adenocarcinoma cells. - hsa_circ_MYBL2 circ-MYBL2 DOID:4074 pancreatic adenocarcinoma pancreatic adenocarcinoma RT-qPCR down-regulated circ-MYBL2 was downregulated in PA and it downregulated miR-19a through methylation to suppress PA cell proliferation. 1 Circ_0020123 plays an oncogenic role in non-small cell lung cancer depending on the regulation of miR-512-3p/CORO1C. hsa_circ_0020123 - Circ_0020123 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0020123 aggravated NSCLC progression by binding to miR-512-3p to induce CORO1C expression, which provided new potential targets for the treatment of NSCLC." 9 Circ_0009035 regulates the progression of cervical cancer by targeting miR-1305/CREBRF axis. hsa_circ_0009035 - Circ_0009035 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circ_0009035 could influence the development of cervical cancer through the targeted regulation of miR-1305/CREBRF. 2 "Hsa_circ_0056686, derived from cancer-associated fibroblasts, promotes cell proliferation and suppresses apoptosis in uterine leiomyoma through inhibiting endoplasmic reticulum stress." hsa_circ_0056686 hsa_circ_KIF5C "circ_0056686," DOID:13957 uterine corpus lipoleiomyoma uterine leiomyoma RT-qPCR up-regulated "Hsa_circ_0056686 contributed to tumor-promoting effects of CAFs in ULM, manifested by promoting ULM cell proliferation and migration and reducing ERS-induced apoptosis through sponging miR-515-5p." 2 Circular RNA circ_0001445 alleviates the ox-LDL-induced endothelial injury in human primary aortic endothelial cells through regulating ABCG1 via acting as a sponge of miR-208b-5p. hsa_circ_0001445 - Circ_0001445 DOID:3393 coronary artery disease coronary artery disease RT-qPCR down-regulated "Circ_0001445 could abate ox-LDL-mediated HAEC damage by the miR-208b-5p/ABCG1 axis, providing a novel insight into the pathogenesis and treatment of CAD." 2 Downregulation of Circ-CEP128 Enhances the Paclitaxel Sensitivity of Cervical Cancer Through Regulating miR-432-5p/MCL1. - hsa_circ_CEP128 Circ-CEP128 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated the present study showed that circ-CEP128 silencing could increase the paclitaxel sensitivity of CC by regulating the miR-432-5p/MCL1 axis. 1 "Interfering Hsa_circRNA_0060640 Suppresses TGF-beta2-Induced Proliferation, Motility and EMT in Human Lens Epithelium Cells by Targeting miR-214-3p and Collagen Type I alpha2 Chain." hsa_circ_0060640 - circRNA_0060640 DOID:0070353 cataract posterior capsule opacification RT-qPCR up-regulated "Circ_0060640 is a novel cataract-related gene and its silencing could block TGF-beta2-evoked hLECs proliferation, motility and EMTin vitrovia targeting miR-214-3p-COL1A2 axis. Therefore, targeting circ_0060640 via RNA interference might be a treatment strategy for PCO development." 1 Circ_0000442 functions as a tumor repressor in breast cancer by impacting miR-1229-3p and upregulating ZBTB1. hsa_circ_0000442 - Circ_0000442 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated circ_0000442 impeded the progression of BC by sponging miR-1229-3p to evoke the ZBTB1 expression upregulation. 2 Hsa_circ_0008344 Promotes Glioma Tumor Progression and Angiogenesis Presumably by Regulating miR-638/SZRD1 Pathway. hsa_circ_0008344 hsa_circ_UBAP2 circ_0008344 DOID:0060108 brain glioma glioma tumor RT-qPCR up-regulated "circ_00008344 knockdown suppressed glioma tumor growth. Circ_0008344 might contribute to glioma progression through miR-638/SZRD1 axis, which might be a novel pathology and treatment target in glioma." 1 Circ_0075825 promotes gastric cancer progression via adsorbing miR-432-5p to modulate SOX9. hsa_circ_0075825 - Circ_0075825 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Circ_0075825 promotes GC progression via sponging miR-432-5p to regulate SOX9 expression level, and it may be a novel therapeutic target for treating GC." 1 Aberrant Nuclear Export of circNCOR1 Underlies SMAD7-Mediated Lymph Node Metastasis of Bladder Cancer. - hsa_circ_NCOR1 circNCOR1 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "SUMOylation-induced nuclear export of circNCOR1 as a key event regulating TGFbeta-SMAD signaling and bladder cancer lymphangiogenesis, thus supporting circNCOR1 as a novel therapeutic agent for patients with LN metastatic bladder cancer." 1 The circular RNA circFARSA sponges microRNA-330-5p in tumor cells with bladder cancer phenotype. - hsa_circ_FARSA circFARSA DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated circFARSA expression is upregulated and exerts oncogenic functions in BC by sponging miR-330. 2 circ_0004140 promotes LUAD tumor progression and immune resistance through circ_0004140/miR-1184/CCL22 axis. hsa_circ_0004140 - circ_0004140 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "circ_0004140 may drive resistance to anti-PD-1 immunotherapy, providing a novel potential therapeutic target for LUAD treatment." 1 Hsa_circRNA_0088036 acts as a ceRNA to promote bladder cancer progression by sponging miR-140-3p. hsa_circ_0088036 - circRNA_0088036 DOID:11054 urinary bladder cancer bladder cancer microarray up-regulated "Knockdown of hsa_circRNA_0088036 inhibited the proliferation, migration, and metastasis of BCa cells via miR-140-3p/FOXQ1 signaling, suggesting that hsa_circRNA_0088036 is a potential biomarker and therapeutic target for BCa." 1 Circular RNA hsa_circ_0011298 enhances Taxol resistance of non-small cell lung cancer by regulating miR-486-3p/CRABP2 axis. hsa_circ_0011298 hsa_circ_TINAGL1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0011298 elevated Taxol resistance of NSCLC by sponging miR-486-3p and upregulating CRABP2, providing a possible circRNA-targeted therapy for NSCLC." 2 Exosomal circGSE1 promotes immune escape of hepatocellular carcinoma by inducing the expansion of regulatory T cells. - hsa_circ_GSE1 circGSE1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated exosomal circGSE1 can be used as a promising biomarker for immunotherapy of HCC. 1 Exosomal circDNER enhances paclitaxel resistance and tumorigenicity of lung cancer via targeting miR-139-5p/ITGB8. - hsa_circ_DNER circDNER DOID:1324 lung cancer lung cancer RT-qPCR up-regulated The circDNER mediated miR-139-5p/ITGB8 axis suppresses lung cancer progression. Our findings suggest that circDNER might act as a potential prognostic biomarker and therapeutic target for lung cancer treatment. 1 Association of has_circ_0001944 upregulations with prognosis and cancer progression in patients with colorectal cancer. hsa_circ_0001944 hsa_circ_TCONS_l2_00030860 circ_0001944 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Up-regulation of has_circ_0001944 is associated with a poor prognosis of CRC. has_circ_0001944 downregulation can slow the progression of CRC partly by targeting miR-548b-3p. 1 CirRNA circFAM126A Exerts Oncogenic Functions in NSCLC to Upregulate IRS2. - hsa_circ_FAM126A circFAM126A DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circFAM126A could function as a miRNA sponge for miR-613 to regulate the expression of IRS2, thereby regulating proliferation, migration, invasion, apoptosis, and cell cycle arrest in NSCLC cells." 1 Administration of circRNA_0075932 shRNA exhibits a therapeutic effect on burn-associated infection in obese rats. hsa_circ_0075932 - circRNA_0075932 DOID:0050117 disease by infectious agent burn-associated infection RT-qPCR down-regulated "the expression of circ_0075932 in adipose tissue is evidently increased in burn-associated infection in obese rats. Moreover, the administration of circ_0075932 shRNA exhibited a therapeutic effect upon burn-associated infection in obese rats by suppressing the expression of circ_0075932." 1 CircPOLR2A Promotes Proliferation and Impedes Apoptosis of Glioblastoma Multiforme Cells by Up-regulating POU3F2 to Facilitate SOX9 Transcription. - hsa_circ_POLR2A CircPOLR2A DOID:3073 brain glioblastoma multiforme glioblastoma multiforme RT-qPCR up-regulated "circPOLR2A enhanced the transcription of SOX9 through miR-2113/POU3F2 axis, thus exacerbating GBM cells growth." 2 CircP4HB regulates ferroptosis via SLC7A11-mediated glutathione synthesis in lung adenocarcinoma. - hsa_circ_P4HB CircP4HB DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "circP4HB acts as a novel ferroptosis suppressor in LUAD. Furthermore, circP4HB protects LUAD from ferroptosis via modulation of the miR-1184/SLC7A11 axis. Our findings identified circP4HB as a novel biomarker in LUAD and warrants further investigation in the early diagnosis and treatment of LUAD." 1 CircSEC24A (hsa_circ_0003528) interference suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells via miR-421/MMP3 axis. hsa_circ_0003528 hsa_circ_SEC24A CircSEC24A DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray up-regulated circSEC24A could represent a potential target for HCC patient treatment. 4 Circular RNA CircITCH (has-circ-0001141) suppresses hepatocellular carcinoma (HCC) progression by sponging miR-184. hsa_circ_0001141 hsa_circ_ITCH CircITCH DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "circITCH served as a repressor to restrain HCC malignancy via miR-184. Therefore, circITCH may serve as a potential prognostic marker and therapeutic target for HCC." 5 Circle RNA circ_0007331 promotes colorectal carcinoma by targeting miR-205-5p/high-mobility group A2 axis. hsa_circ_0007331 - circ_0007331 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "the circ_0007331/miR-205-5p/HMGA2 axis promotes CRC development. Thus, circ_0007331 may be a potential biomarker for CRC." 1 "Sevoflurane Suppresses the Proliferation, Migration and Invasion of Colorectal Cancer Through Regulating Circ_0000423/miR-525-5p/SGPP1 Network." hsa_circ_0000423 - Circ_0000423 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Our results showed that SEV inhibited CRC progression through the regulation of circ_0000423/miR-525-5p/SGPP1 axis. 1 "lncRNA ADAMTS9-AS1/circFN1 Competitively Binds to miR-206 to Elevate the Expression of ACTB, Thus Inducing Hypertrophic Cardiomyopathy." - hsa_circ_FN1 circFN1 DOID:11984 hypertrophic cardiomyopathy hypertrophic cardiomyopathy microarray down-regulated "ADAMTS9-AS1/circFN1-miR-206-ACTB regulatory network may involve in HCM occurrence, providing a novel theoretical basis for in-depth understanding of mechanism of HCM." 1 CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7. - hsa_circ_HGF CircHGF DOID:10159 osteonecrosis osteonecrosis of the femoral head microarray up-regulated Our findings provided a potential diagnostic and therapeutic strategy for ONFH. 1 Identification of a circRNA-mediated comprehensive ceRNA network in spinal cord injury pathogenesis. hsa_circ_0026646 - hsa_circ_0026646 DOID:319 spinal cord disease spinal cord injury "RT-qPCR, microarray" up-regulated "in SCI pathogenesis, hsa_circ_0026646 correlates withPLXNB2by targeting miR-331-3p." 1 Identification of a novel circ_0001946/miR-1290/SOX6 ceRNA network in esophageal squamous cell cancer. hsa_circ_0001946 - circ_0001946 DOID:1107 esophageal carcinoma esophageal squamous cell cancer RT-qPCR down-regulated "Our findings uncover an undescribed molecular mechanism, the circ_0001946/miR-1290/SOX6 ceRNA crosstalk, for the anti-ESCC activity of circ_0001946." 1 Circular RNA circ_0004277 Inhibits Acute Myeloid Leukemia Progression Through MicroRNA-134-5p / Single stranded DNA binding protein 2. hsa_circ_0004277 - circ_0004277 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR down-regulated circ_0004277 impedes AML development by adsorbing miR-134-5p and up-regulating SSBP2. 1 Circular RNA Eps15-homology domain-containing protein 2 induce resistance of renal cell carcinoma to sunitinib via microRNA-4731-5p/ABCF2 axis. - hsa_circ_EHD2 circEHD2 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "circEHD2 enhances RCC resistance to SU via acting as a miR-4731-5p sponge to mediate ABCF2. MiR-4731-5p can target circEHD2 and ABCF2, thus providing a novel and effective therapeutic against renal cell carcinoma." 2 Circ_KCNQ5 participates in the progression of childhood acute myeloid leukemia by enhancing the expression of RAB10 via binding to miR-622. - hsa_circ_KCNQ5 Circ_KCNQ5 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "Circ_KCNQ5 high expression was associated with childhood AML malignant development, and circ_KCNQ5 participated in AML progression by regulating the miR-622/RAB10 pathway." 2 CircDYM ameliorates CUMS mice depressive-like behavior and inhibits hippocampal neurons injury via miR-497a-5p/NR3C1 axis. - hsa_circ_DYM CircDYM DOID:150 disease of mental health chronic unpredictable mild stress RT-qPCR down-regulated "circDYM could relieve the depressive-like behavior in CUMS mice and hippocampal neurons injury through miR-497a-5p/NR3C1 pathway. These data confirmed that circDYM had an anti-depressive function, which might be a potential target for depression treatment." 1 Circular RNA circ_0051620 sponges miR-338-3p and regulates ADAM17 to promote the gastric cancer progression. hsa_circ_0051620 - circ_0051620 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "The overexpression of circ_0051620 is found to be associated with progress and poor prognosis of GC, promoting the development and metastasis via sponging miR-338-3p and decoying ADAM17." 1 Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury. hsa_circ_0050908 - Circ_0050908 DOID:936 brain disease ischemia-reperfusion RT-qPCR up-regulated "Circ_0050908 knockdown protects cardiomyocytes against I/R injury by reducing apoptosis, inflammatory response, and oxidative stress through miR-324-5p/TRAF3 axis, revealing a novel therapeutic strategy for preventing myocardial I/R injury." 1 Down-regulated Circ_0000190 promotes cervical cancer by facilitating the activity of proto-oncogene protein EIF4E. hsa_circ_0000190 - Circ_0000190 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In our investigation, a novel tumor suppressive gene circ_0000190 was recognized, which could be treated as a promising biomarker for the diagnosis of CC." 1 The regulation of hsacirc_004413 promotes proliferation and drug resistance of gastric cancer cells by acting as a competing endogenous RNA for miR-145-5p. - - circ_004413 DOID:10534 stomach cancer gastric cancer RNA-seq up-regulated "we suggested that hsacirc_004413 inhibited apoptosis by sponging miR-145-5p, thereby promoting SGC-7901-5-Fu cell proliferation, and chemoresistance. These findings provided new insights into the mechanism of 5-Fu resistant gastric cancer, which is an urgent clinical problem to be solved." 1 "circ-CFH promotes the development of HCC by regulating cell proliferation, apoptosis, migration, invasion, and glycolysis through the miR-377-3p/RNF38 axis." - hsa_circ_CFH circ-CFH DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "the circ-CFH/miR-377-3p/RNF38 axis regulated the progression of HCC cells, which might provide new diagnostic markers for HCC." 3 Inhibition of Circ-Snrk ameliorates apoptosis and inflammation in acute kidney injury by regulating the MAPK pathway. - hsa_circ_Snrk circ-Snrk DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" up-regulated Circ-Snrk is involved in AKI development and associated with the MAPK signaling pathway in AKI. 1 CircRFX3 Up-regulates Its Host Gene RFX3 to Facilitate Tumorigenesis and Progression of Glioma. - hsa_circ_RFX3 CircRFX3 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "CircRFX3, as a tumor promoter, could recruit HNRNPK to stabilize RFX3 mRNA in glioma cells. Additionally, RFX3 could promote PROX1 transcription to promote glioma progression." 2 Circ_0000854 regulates the progression of hepatocellular carcinoma through miR-1294 /IRGQ axis. hsa_circ_0000854 - Circ_0000854 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0000854 accelerated HCC progression via the miR-1294/IRGQ axis, providing a novel regulatory mechanism for HCC pathogenesis." 1 The upregulation of circFNDC3B aggravates the recurrence after endoscopic submucosal dissection (ESD) in early gastric cancer (EGC) patients. - hsa_circ_FNDC3B circFNDC3B DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "In summary, our study demonstrated that a higher level of circFNDC3B could lead to the increased expression of CD44 and CDH1 via modulating the signaling pathways of miR-942/CD44 and miR-510/CDH1 in EGC patients. And the up-regulation of CD44 and CDH1 would accordingly result in a higher recurrence rate of EGC patients treated by ESD." 4 CircINTS4 Facilitates Chemoresistance of TNBC by Competitively Binding miR-129-5p/POM121 Axis. - hsa_circ_INTS4 CircINTS4 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "CircRNA circINTS4 may act as the ceRNA of miR-129-5p to regulate the expression of target gene POM121, thereby promoting the progress of TNBC molecular mechanism and providing scientific basis for circINTS4 as a new molecular target for clinical diagnosis and drug resistance therapy of TNBC." 1 Circulating cell-free circRNA panel predicted tumorigenesis and development of colorectal cancer. - - Circulating cell-free circRNA DOID:9256 colorectal cancer colorectal cancer microarray up-regulated "Our data suggest that hsa_circ_001978, hsa_circ_105039, and hsa_circ_103627 might be a CRC-specific biomarker for early diagnosis." 1 CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the Proliferation and Metastasis of Colorectal Cancer by Regulating HOXD8. - hsa_circ_TMEM59 CircTMEM59 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "In summary, our results demonstrated that circTMEM59 participated in the regulation of CRC progression through the miR-410-3p/HOXD8 axis, showing that circTMEM59 might be a potential target for the treatment of CRC." 2 Hsa_circ_0081534 facilitates malignant phenotypes by sequestering miR-874-3p and upregulating FMNL3 in nasopharyngeal carcinoma. hsa_circ_0081534 hsa_circ_EPHB4 circ_0081534 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated circ_0081534 interference repressed NPC progression partly by modulating the miR-874-3p/FMNL3 axis. 1 Downregulation of circLPAR3 inhibits tumor progression and glycolysis by liberating miR-144-3p and upregulating LPCAT1 in oral squamous cell carcinoma. - hsa_circ_LPAR3 circLPAR3 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "CircLPAR3 exerted a tumor-promoting effect on OSCC growth through elevating LPCAT1 expression via functioning as a miR-144-3p sponge. This study supports the possible role of circLPAR3 in the diagnosis, prognosis, and treatment of OSCC." 3 Circular RNA circ_0065378 upregulates tumor suppressor candidate 1 by competitively binding with miR-4701-5p to alleviate colorectal cancer progression. hsa_circ_0065378 hsa_circ_PLXNB1 circ_PLXNB1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Circ_PLXNB1 attenuated CRC progression by binding with miR-4701-5p to overexpress TUSC1, indicating that the circ_PLXNB1/miR-4701-5p/TUSC1 axis might be a potential novel molecular target in CRC diagnosis and therapy." 1 Circular RNA 0001823 aggravates the growth and metastasis of the cervical cancer cells through modulating the microRNA-613/RAB8A axis. hsa_circ_0001823 - circ_0001823 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "The circ_0001823 and RAB8A expressions were increased, and miR-613 were decreased in the CC cells and tissues. Knockdown of circ_0001823 inhibited the malignant behavior of the CC cells, which was antagonized by miR-613 inhibitor. Over-expressed RAB8A reversed the miR-613 effects in the CC cells. Knockdown of circ_0001823 inhibited the malignant behaviors of the CC cells via regulating the miR-613/RAB8A axis." 1 Astragaloside IV exhibits anti-tumor function in gastric cancer via targeting circRNA dihydrolipoamide S-succinyltransferase (circDLST)/miR-489-3p/ eukaryotic translation initiation factor 4A1(EIF4A1) pathway. - hsa_circ_DLST circDLST DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated AS-IV inhibited the development of GC through circDLST/miR-489-3p/EIF4A1 axis. 2 CircSETD3 (hsa_circ_0000567) inhibits proliferation and induces apoptosis in cholangiocarcinoma cells via downregulation of microRNA-421 expression. hsa_circ_0000567 hsa_circ_SETD3 CircSETD3 DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR down-regulated "These findings demonstrate that circSETD3 inhibits proliferation and induces apoptosis in CCA cells by regulating the miR-421/BMF axis, indicating its potential as a promising candidate for CCA therapy." 1 CircRNA CTNNB1 (circCTNNB1) ameliorates cerebral ischemia/reperfusion injury by sponging miR-96-5p to up-regulate scavenger receptor class B type 1 (SRB1) expression. - hsa_circ_CTNNB1 circCTNNB1 DOID:936 brain disease ischemia reperfusion injury RT-qPCR up-regulated "In conclusion, our findings suggest that circCTNNB1 acts as a competitive endogenous RNA for miR-96-5p to alleviate cerebral IRI, which provides novel evidence that circCTNNB1 and SRB1 may be biomarkers and therapeutic targets for cerebral IRI." 1 Plasmacytoma variant translocation 1 stabilized by EIF4A3 promoted malignant biological behaviors of lung adenocarcinoma by generating circular RNA LMNB2. - hsa_circ_LMNB2 circLMNB2 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated "Our findings demonstrate that PVT1/EIF4A3/circLMNB2 enhances the malignant behaviors of LUAD cells, providing a novel perspective for the clinical treatment of LUAD." 1 Circular RNA circ_0067741 regulates the Hippo/YAP pathway to suppress lung adenocarcinoma progression by targeting microRNA-183-5p. hsa_circ_0067741 - circ_0067741 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated "In conclusion, circ_0067741 sponges miR-183-5p, and regulates LATS1 to activate Hippo/YAP pathway, thereby inhibiting the process of LUAD cells. And the circ_0067741/miR-183-5p/LATS1 axis can be a potential target for early diagnosis and targeted treatment of LUAD." 1 "CircXRCC5, as a Potential Novel Biomarker, Promotes Glioma Progression via the miR-490-3p/XRCC5/CLC3 Competing Endogenous RNA Network." - hsa_circ_XRCC5 "CircXRCC5," DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Collectively, circXRCC5 promoted glioma progression via the miR-490-3p/XRCC5/CLC3 ceRNA network, providing a novel prognostic biomarker and a prospective target for glioma treatment." 2 CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis. - - CircRNA608 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, RNA-seq" down-regulated Circ608 could promote PINK1-mediated mitophagy of HSCs though inhibiting miR222 in NASH-related liver fibrosis. 1 circFAM120B functions as a tumor suppressor in esophageal squamous cell carcinoma via the miR-661/PPM1L axis and the PKR/p38 MAPK/EMT pathway. hsa_circ_0001666 hsa_circ_FAM120B circFAM120B DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR down-regulated "Our findings suggest that circFAM120B is a promising biomarker of ESCC, which acts as a tumor suppressor via the circFAM120B/miR-661/PPM1L axis and PKR/p38 MAPK/EMT pathway, supporting its significance as a candidate therapeutic target." 1 CircCDC6 restrains tumor growth and glycolysis energy metabolism in colorectal cancer via regulating miR-3187-3p and downstream PRKAA2. - hsa_circ_CDC6 CircCDC6 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "CircCDC6, acting as a tumor inhibitor, repressed tumor growth and glycolysis metabolism in CRC via targeting the miR-3187-3p/PRKAA2 axis, which partly clarified the role of circCDC6 in CRC." 1 CircRNA hsa_circ_0071336 is associated with type 2 diabetes through targeting the miR-93-5p/GLUT4 axis. hsa_circ_0071336 hsa_circ_FNIP2 - DOID:9352 type 2 diabetes mellitus type 2 diabetes RT-qPCR down-regulated "In conclusion, hsa_circRNA_0071336 can be considered as a potential novel and stable biomarker for T2D and its early detection. hsa_circ_0071336 regulates the GLUT4 expression by sponging miR-93-5p and maybe involved in the pathogenesis of T2D. These findings may unveil new targets for the prevention, diagnosis and treatment of T2D." 1 Circular RNA circ_0000423 regulates cartilage ECM synthesis via circ_0000423/miRNA-27b-3p/MMP-13 axis in osteoarthritis. hsa_circ_0000423 - Circ_0000423 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated These findings confirmed that the Circ_0000423-miRNA-27b-3p-MMP-13 axis could affect the pathogenesis of OA which might lead to a novel target for diagnostic molecular biological indicators and potential OA treatments. 1 CircRNA circ_0023984 promotes the progression of esophageal squamous cell carcinoma via regulating miR-134-5p/cystatin-s axis. hsa_circ_0023984 - circ_0023984 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "Together, our study indicates that the oncogenic role of Circ_0023984 is mediated by miR-134-5p/CST4 Axis in ESCC, which could serve as potential targets for future therapeutic strategies." 1 circHECTD1 attenuates apoptosis of alveolar epithelial cells in acute lung injury. - hsa_circ_HECTD1 circHECTD1 DOID:850 lung disease acute lung injury RT-qPCR down-regulated Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI. 1 "CircMYC promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting miR-145/ Matrix Metallopeptidase 2 axis." - hsa_circ_MYC CircMYC DOID:1324 lung cancer lung cancer RT-qPCR up-regulated These findings suggest that targeting circMYC/miR-145/MMP-2 could serve as a potential therapeutic strategy for SCLC treatment. 1 circHIPK3 regulates cell proliferation and migration by sponging microRNA-124 and regulating serine/threonine kinase 3 expression in esophageal squamous cell carcinoma. - hsa_circ_HIPK3 circHIPK3 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated Our findings indicate that circHIPK3 acts as an oncogene in ESCC and that the circHIPK3-AKT3_xis may be a therapeutic target for patients with ESCC. 1 Downregulation of circATXN7 represses non-small cell lung cancer growth by releasing miR-7-5p. hsa_circ_0066436 hsa_circ_ATXN circATXN7 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircATXN7 accelerated the malignancy of NSCLC cells through adsorbing miR-7-5p and upregulating PFN2, offering evidence to support circATXN7 as a target for NSCLC treatment." 1 "Exosomal circular RNA hsa_circ_0006220, and hsa_circ_0001666 as biomarkers in the diagnosis of pancreatic cancer." hsa_circ_0006220 hsa_circ_TADA2A Exosomal circular RNA DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" up-regulated The high expression of exosomal hsa_circ_0001666 and hsa_circ_0006220 suggests that these can be used as new biomarkers for the diagnosis and treatment of pancreatic cancer. 1 hsa_circ_0000285 facilitates thyroid cancer progression by regulating miR-127-5p/CDH2. hsa_circ_0000285 hsa_circ_HIPK3 circ_0000285 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "hsa_circ_0000285 induced the development of THCA via functioning as a competing endogenous RNA (ceRNA) of miR-127-5p to enhance CDH2 expression, which provided a new perspective for THCA therapy." 3 Circular RNA circTLK1 regulates dopaminergic neuron injury during Parkinson disease by targeting miR-26a-5p/DAPK1. - hsa_circ_TLK1 circTLK1 DOID:14330 Parkinson disease Parkinson disease RT-qPCR up-regulated "Depletion of circTLK1 mitigates dopaminergic neuron injury in vitro and in vivo, via releasing miR-26a-5p to target DAPK1 expression. Targeting circTLK1 may contribute to improving PD therapy." 1 CircACTR2 in macrophages promotes renal fibrosis by activating macrophage inflammation and epithelial-mesenchymal transition of renal tubular epithelial cells. - hsa_circ_ACTR2 CircACTR2 DOID:0050855 renal fibrosis renal fibrosis RT-qPCR up-regulated "In summary, circACTR2, by sponging miR-561, activated NLRP3 inflammasome, promoted macrophage inflammation, and stimulated macrophage-induced EMT and fibrosis of TECs. Knocking down circACTR2 and overexpressing miR-561 may, thus, benefit the treatment of renal fibrosis." 1 Retinal Circular RNA hsa_circ_0087207 Expression Promotes Apoptotic Cell Death in Induced Pluripotent Stem Cell-Derived Leber Hereditary Optic Neuropathy-like Models. hsa_circ_0087207 hsa_circ_ALDH1A1 - DOID:705 Leber hereditary optic neuropathy Leber hereditary optic neuropathy "RT-qPCR, RNA-seq" up-regulated Our data indicated that hsa_circ_0087207 upregulation distinguishes the disease phenotype manifestations between iPSC-derived RGCs generated from the LHON patient and carrier. Targeting the hsa_circ_0087207/miR-665 axis might hold therapeutic promises for the treatment of LHON. 1 Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma. - hsa_circ_MTHFD1L circ-MTHFD1L DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated Circ-MTHFD1L maintains PDAC gemcitabine resistance through the miR-615-3p/RPN6 signal axis. Circ-MTHFD1L may be a molecular marker for the effective treatment of PDAC. 1 Circ_0030998 Restrains Cisplatin Resistance Through Mediating miR-1323/PDCD4 Axis in Non-small Cell Lung Cancer. hsa_circ_0030998 - Circ_0030998 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated Circ_0030998 suppressed DDP resistance and NSCLC progression depending on the regulation of miR-1323/PDCD4 axis. 1 Identification of the regulatory role of the circ_0004788/miR-515-5p/FGF2 network in nasopharyngeal carcinoma development. hsa_circ_0004788 - circ_0004788 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR dysregulated Circ_0004788 knockdown restrained the progression of NPC via the miR-515-5p/FGF2 axis. 1 Breast cancer derived exosomes promoted angiogenesis of endothelial cells in microenvironment via circHIPK3/miR-124-3p/MTDH axis. - hsa_circ_HIPK3 circHIPK3 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circHIPK3 enclosed in the BC cell-derived exosomes enhanced MTDH expression in the endothelial cell by sponging miR-124-3p, favoring the tube formation in ECs, which might serve as a therapeutic target for anti-angiogenesis therapy for breast cancer." 4 Circ_0088036 mediated progression and inflammation in fibroblast-like synoviocytes of rheumatoid arthritis by miR-1263/REL-activated NF-kappaB pathway. hsa_circ_0088036 - Circ_0088036 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "These findings suggested that circ_0088036/miR-1263/REL/NF-¦ĘB pathway was involved in the functional development of HFLS-RA cells, indicating a novel molecular network in RA progression in vitro." 3 Upregulated Circular RNA KIF4A Promotes Cell Migration and Invasion by Regulating MicroRNA-144-3p/EZH2 Axis in Gastric Cancer. - hsa_circ_KIF4A circKIF4A DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated This study indicated that circKIF4A can efficiently sponge miR-144-3p to promote the malignant behaviors of GC cells and may provide a potential biomarker and therapeutic target for GC management. 1 CircHIPK3 Regulates Vascular Smooth Muscle Cell Calcification Via the miR-106a-5p/MFN2 Axis. - hsa_circ_HIPK3 CircHIPK3 DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated "CircHIPK3 regulated osteogenic and cartilage differentiation of VSMC via miR-106a-5p/MFN2 axis, indicating a target for treating vascular calcification." 2 Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis. - hsa_circ_VMP1 circVMP1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Exosome-mediated transmission of circVMP1 promoted NSCLC progression and DDP resistance by targeting miR-524-5p-METTL3/SOX2 axis.HighlightsCircVMP1 level is up-regulated in DDP-resistant NSCLC cell lines compared with DDP-sensitive cell lines.CircVMP1 absence restrains the malignant behaviors and DDP resistance of A549/DDP and H1299/DDP cells.CircVMP1-miR-524-5p/METTL3/SOX2 axis is identified for the first time.CircVMP1 plays an oncogenic role by targeting miR-524-5p-METTL3/SOX2 axis in A549/DDP and H1299/DDP cells.Exosomal circVMP1 transmits the malignant properties and DDP resistance to DDP-sensitive cells. 1 Circular RNA circ_0002594 regulates PDGF-BB-induced proliferation and migration of human airway smooth muscle cells via sponging miR-139-5p/TRIM8 in asthma. hsa_circ_0002594 - circ_0002594 DOID:2841 asthma asthma RT-qPCR up-regulated "Our findings revealed that circ_0002594 could act as a regulator in the airway remodelling during asthma development partly by the miR-139-5p/TRIM8 axis, hinting at an underlying therapeutic strategy for asthma." 1 Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA. - hsa_circ_CCNB1 circCCNB1 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR down-regulated "This study reveals a novel biological function of circCCNB1 in the migration and invasion of NPC by enhancing the tight junctions of cancer cells by binding to NF90 proteins and TJP1 mRNA, and may provide a potential therapeutic target for NPC." 1 HIF1alpha-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression. hsa_circ_0001875 - circ-0001875 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" up-regulated Our results revealed that the circ-0001875/miR-31-5p/SP1 axis and the complex regulatory loops influence NSCLC progression. These findings provide new insights into the regulation of circRNA formation under tumor hypoxia. 1 Molecular mechanism of m(6)A methylation of circDLC1 mediated by RNA methyltransferase METTL3 in the malignant proliferation of glioma cells. - hsa_circ_DLC1 circDLC1 DOID:0060108 brain glioma glioma RT-qPCR down-regulated "Collectively, METTL3-mediated m6A modification upregulated circDLC1 expression, and circDLC1 promoted CTNNBIP1 transcription by sponging miR-671-5p, thus repressing the malignant proliferation of glioma." 1 "Knockdown of circMYOF inhibits cell growth, metastasis, and glycolysis through miR-145-5p/OTX1 regulatory axis in laryngeal squamous cell carcinoma." - hsa_circ_MYOF circMYOF DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "we found that circMYOF was significantly overexpressed in the serum exosomes of LSCC patients. Our data revealed that circMYOF contributed to LSCC progression by promoting cell growth, metastasis, and glycolysis through miR-145-5p/OTX1 axis." 1 Activation of circ_0072088/miR-1261/PIK3CA pathway accelerates lung adenocarcinoma progression. hsa_circ_0072088 - circ_0072088 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "Circ_0072088-dependent regulation of miR-1261/PIK3CA is important for cell proliferation, migration, and invasion during the tumorigenesis and progression of LUAD, warranting the need to consider the circ_0072088/miR-1261/PIK3CA regulatory pathway as a potential therapeutic target in patients with lung adenocarcinoma." 2 "Knockdown of circ_0067934 inhibits gastric cancer cell proliferation, migration and invasion via the miR_1301_3p/KIF23 axis." hsa_circ_0067934 - circ_0067934 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "In conclusion, circ_0067934 may regulate the proliferation, invasion and migration of GC cells via the miR_1301_3p/KIF23 signaling axis, which may represent a novel therapeutic target for GC metastasis." 3 CircMCTP2 (has-circ-0000658) facilitates the proliferation and metastasis of bladder carcinoma through modulating the miR-498/murine double minute-2 axis. hsa_circ_0000658 hsa_circ_MCTP2 CircMCTP2 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "In conclusion, our study showed that circMCTP2 regulates the expression of MDM2 by sponging miR-498 to promote the development of BC. These findings offer a new strategy for early diagnosis of BC and its therapeutics." 2 The effect of low molecular weight-polycyclic aromatic hydrocarbons responsive hsa_circ_0039929/hsa-miR-15b-3p_R-1/FGF2 circuit on inflammatory response of A549 cells via the PI3K/AKT pathway and epithelial-mesenchymal transition process. hsa_circ_0039929 hsa_circ_NFATC3 circ_0039929 DOID:850 lung disease Inflammation RNA-seq up-regulated All above suggested that ceRNA hsa_circ_0039929/hsa-miR-15b-3p_R-1/FGF2 played an important role in the inflammation and EMT caused by LMW-PAHs. 1 Upregulation of hsa_circ_0000977 participates in esophageal squamous cancer progression by sponging miR-874-3p. hsa_circ_0000977 hsa_circ_NOL10 circ_0000977 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated Disordered hsa_circ_0000977 expression can promote carcinogenesis in ESCC and might serve as a diagnostic biomarker to evaluate the occurrence and development of esophageal cancer. 1 Circ_NNT suppresses the apoptosis and inflammation in glucose-induced human retinal pigment epithelium by regulating miR-320b/TIMP3 axis in diabetic retinopathy. - hsa_circ_NNT circ_NNT DOID:8947 diabetic retinopathy Diabetic retinopathy RT-qPCR down-regulated "Circ_NNT protected ARPE-19 cells against HG-evoked apoptosis and inflammation via elevating TIMP3 through sequestering miR-320b, indicating that up-regulation of circ_NNT might contribute to the inhibition of DR process." 2 "Circular RNA mitochondrial translation optimization 1 correlates with less lymph node metastasis, longer disease-free survival, and higher chemotherapy sensitivity in gastric cancer." - hsa_circ_MTO1 Circ-MTO1 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Circ-MTO1 correlates with less lymph node metastasis, prolonged DFS, and improved chemotherapy sensitivity in gastric cancer." 3 Circular RNA Fbxl5 Regulates Cardiomyocyte Apoptosis During Ischemia Reperfusion Injury via Sponging microRNA-146a. - hsa_circ_Fbxl5 CircRNA Fbxl5 DOID:936 brain disease ischemia reperfusion injury RT-qPCR up-regulated "Our findings revealed a novel and critical role for circRNA Fbxl5 in regulating cardiomyocyte apoptosis, and added additional insight into circRNAs mediated during myocardial IRI. The underlying miR-146a-MED1 signaling serves as an important cascade in regulating the apoptosis of cardiomyocytes." 1 CircTRHDE knockdown protects WI-38 cells against LPS-induced inflammatory injury. - hsa_circ_TRHDE circTRHDE DOID:552 pneumonia pneumonia RT-qPCR up-regulated "Our findings demonstrated that circTRHDE might be a target for infantile pneumonia treatment, which relieved LPS-induced cell inflammatory injury by the regulation of the miR-318-3p/TRAF3 axis." 2 Circular GOLPH3 RNA exerts oncogenic effects in vitro by regulating the miRNA-1299/LIF axis in oral squamous cell carcinoma. - hsa_circ_GOLPH3 circGOLPH3 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "These findings indicate that the circGOLPH3/miR-1299/LIF axis promotes OSCC cell growth, migration, and invasion and that this axis is a potential therapeutic target for OSCC." 2 Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5. hsa_circ_0010729 hsa_circ_HSPG2 circ_0010729 DOID:6713 cerebrovascular disease Ischemic stroke RT-qPCR up-regulated "Hsa_circ_0010729 regulated miR-665/ING5 axis in OGD/R-induced HBMECs. Therefore, hsa_circ_0010729 may be a new therapeutic target for ischemic stroke." 1 "Circular ribonucleic acid nucleoporin 98 knockdown alleviates high glucose-induced proliferation, fibrosis, inflammation and oxidative stress in human glomerular mesangial cells by regulating the microribonucleic acid-151-3p-high mobility group AT-hook 2 axis." - hsa_circ_NUP98 circNUP98 DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "CircNUP98 knockdown alleviates HG-induced proliferation, fibrosis inflammation and oxidative stress in HMCs by regulating the miR-151-3p-HMGA2 axis, which might provide a potential approach for DN therapeutics." 1 CircRNA OXCT1 promotes the malignant progression and glutamine metabolism of non-small cell lung cancer by absorbing miR-516b-5p and upregulating SLC1A5. - hsa_circ_OXCT1 circ-OXCT1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ-OXCT1 facilitated NSCLC progression via miR-516b-5p-dependent regulation of SLC1A5, which provided a possible circRNA-targeted therapy for NSCLC." 1 CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer. - hsa_circ_MAN1A2 CircMAN1A2 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Helicobacter pylori induced circMAN1A2 expression to promote the carcinogenesis of gastric cancer, and circMAN1A2 might be a new potential diagnostic marker and therapeutic target for gastric cancer." 2 hMSCs-derived exosome circCDK13 inhibits liver fibrosis by regulating the expression of MFGE8 through miR-17-5p/KAT2B. - hsa_circ_CDK13 circCDK13 DOID:409 liver disease liver fibrosis RT-qPCR up-regulated hMSCs-derived exosome circCDK13 inhibited liver fibrosis by regulating the expression of MFGE8 through miR-17-5p/KAT2B axis. 1 CircCRIM1 promotes nasopharyngeal carcinoma progression via the miR-34c-5p/FOSL1 axis. - hsa_circ_CRIM1 CircCRIM1 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "Silencing circCRIM1 inhibited the tumorigenesis of NPC. Thus, circCRIM1 might be a novel target for NPC." 2 Mechanism for Bioactive Nanomaterial circ0024831 Regulation of Staphylococcal Nuclease Domain Containing 1 via RNA Methylation Recognition in Osteosarcoma. hsa_circ_0024831 - circ0024831 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "The down-regulation of circ0024831 expression in osteosarcoma cells relieved inhibition of SND1 which lead to change of tumor-related gene expression profile, promoting the occurrence and development of osteosarcoma." 1 Down-regulated HSA_circ_0003528 inhibits hepatocellular carcinoma aggressiveness via the miR-212-3p/XIAP axis. hsa_circ_0003528 hsa_circ_SEC24A circ_0003528 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circ_0003528 contributes to the development of HCC_n vitro_nd_n vivo_ia the miR-212-3p/XIAP_xis. Hence, circ_0003528 knockdown may be a potential therapeutic strategy for HCC treatment." 4 Upregulation of circ_0059961 suppresses cholangiocarcinoma development by modulating miR-629-5p/SFRP2 axis. hsa_circ_0059961 - circ_0059961 DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR down-regulated "Upregulation of circ_0059961 augmented SFRP2 expression by targeting miR-629-5p, which blocked cholangiocarcinoma tumor cell proliferation, migration, and invasion." 1 CircRNA PTPRM Promotes Non-Small Cell Lung Cancer Progression by Modulating the miR-139-5p/SETD5 Axis. - hsa_circ_PTPRM circPTPRM DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated We thus conclude that circPTPRM promotes the progression of NSCLC by regulating the miR-139-5p/SETD5 axis. 1 Evaluation of Diagnostic and Prognostic Value of hsa_circ_0084927 and Analysis of Associated ceRNA Network in Colorectal Cancer. hsa_circ_0084927 hsa_circ_ESRP1 circ_0084927 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Our research results indicate that hsa_circ_0084927 has a cancer-promoting effect and may be used as a circulating tumor marker for COAD prognosis. In addition, this study proposes a new ceRNA network to provide new insights for the targeted therapy of COAD." 2 Silencing circOMA1 Inhibits Osteosarcoma Progression by Sponging miR-1294 to Regulate c-Myc Expression. - hsa_circ_OMA1 circOMA1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circOMA1 played the role of an oncogene in osteosarcoma and promoted osteosarcoma progression by mediating the miR-1294/c-Myc pathway, which might be a new target for treating osteosarcoma." 4 Mechanism of RNA circHIPK3 Involved in Resistance of Lung Cancer Cells to Gefitinib. - hsa_circ_HIPK3 circHIPK3 DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "In summary, the circular RNA circHIPK3 may have a notably low expression in lung cancer tissues, whose low expression had a certain enhancement effect on the drug resistance of lung adenocarcinoma cells to gefitinib." 4 Integrated bioinformatics analysis for the identification of hub genes and signaling pathways related to circANRIL. - hsa_circ_ANRIL circANRIL DOID:1936 atherosclerosis atherosclerosis "RT-qPCR, RNA-seq" up-regulated COL5A2 and WDR3 showed significantly different expression in circANRIL-OE cells. 4 Circular RNA hsa_circ_0004396 acts as a sponge of miR-615-5p to promote non-small cell lung cancer progression and radioresistance through the upregulation of P21-Activated Kinase 1. hsa_circ_0004396 hsa_circ_HUWE1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our findings demonstrated that hsa_circ_0004396 promoted NSCLC development and radioresistance through the miR-615-5p/PAK1 axis, which might provide a new therapeutic target for NSCLC treatment." 2 Circ_0005397 enhances hepatocellular carcinoma progression through miR-1283/HEG1. hsa_circ_0005397 - Circ_0005397 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0005397 regulated HEG1 by targeting miR-1283, thereby promoting HCC development." 3 CircHIPK3 alleviates inflammatory response and neuronal apoptosis via regulating miR-382-5p/DUSP1 axis in spinal cord injury. - hsa_circ_HIPK3 CircHIPK3 DOID:319 spinal cord disease spinal cord injury RT-qPCR down-regulated "CircHIPK3 overexpression alleviated OGD-induced AGE1.HN cell inflammatory response and neuronal apoptosis via regulating miR-382-5p/DUSP1 axis, indicating that circHIPK3 might be a promising therapeutic target for SCI." 2 CircRNA VPRBP inhibits tumorigenicity of cervical cancer via miR-93-5p/FRMD6 axis. - hsa_circ_VPRBP circ_VPRBP DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated "Circ_VPRBP inhibited cell proliferation, migration and invasion and promoted cell apoptosis of cervical cancer cells by regulating miR-93-5p/FRMD6 axis." 4 "Circular RNA CircSHKBP1 accelerates the proliferation, invasion, angiogenesis, and stem cell-like properties via modulation of microR-766-5p/high mobility group AT-hook 2 axis in laryngeal squamous cell carcinoma." - hsa_circ_SHKBP1 circSHKBP1 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "In conclusion, circSHKBP1 accelerated the tumorigenesis of LSCC via modulating HMGA2 by targeting miR-766-5p." 1 Circular RNA circMRPS35 regulates progression and autophagy in osteosarcoma cells by recruiting KAT6B to govern FOXO3. - hsa_circ_MRPS35 circMRPS35 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated we concluded that circRNA circMRPS35 repressed progression and induced autophagy of osteosarcoma cells. 1 CircATRNL1 increases acid-sensing ion channel 1 to advance epithelial-mesenchymal transition in endometriosis by binding to microRNA-103a-3p. - hsa_circ_ATRNL1 CircATRNL1 DOID:288 endometriosis of uterus endometriosis RT-qPCR up-regulated Our study supported that circATRNL1 might be a novel therapeutic candidate target for endometriosis treatment and provided unique insights into the molecular basis concerning the pathogenesis of endometriosis. 1 circDHTKD1 promotes lymphatic metastasis of bladder cancer by upregulating CXCL5. - hsa_circ_DHTKD1 circDHTKD1 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated Our study supports circDHTKD1 as a promising diagnostic and therapeutic target for LN metastasis in BCa. 2 CircRNA circ-ATAD1 suppresses miR-618 maturation to participate in colorectal cancer. - hsa_circ_ATAD1 circ-ATAD1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ-ATAD1 is overexpressed in CRC and may suppress miR-618 maturation to participate in CRC. 1 Circular RNA circSDHC (hsa_circ_0015004) regulates tumor growth and angiogenesis via regulating centrosomal protein 55 expression in renal cell carcinoma. hsa_circ_0015004 hsa_circ_SDHC circSDHC DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "Silencing of circSDHC restrained cell malignant phenotypes and angiogenesis via reducing CEP55 expression by releasing miR-130a-3p in RCC, providing a new mechanism for understanding the progression of RCC." 1 Circ_0000811 acts as a miR-15b sponge and inhibits Prkar2a-mediated JAK2/STAT1 pathway to attenuate cerebral ischemic vertigo. hsa_circ_0000811 - Circ_0000811 DOID:2316 brain ischemia cerebral ischemia RT-qPCR down-regulated "Taken together, our work suggests that circ_0000811 is involved in neuronal apoptosis of CI-induced vertigo and may be used as a biomarker for ameliorating CI-induced vertigo." 1 EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway. - hsa_circ_TOLLIP circTOLLIP DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated our findings indicate that EIF4A3-induced circTOLLIP promotes the progression of HCC through the circTOLLIP/miR-516a-5p/PBX3/EMT axis. 1 circ-0007707/miR-429/PDGFD Pathway Regulates the Progression of Gastric Cancer by Modulating the Immune-Gene Signature. hsa_circ_0007707 - circ-0007707 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "The circ-0007707/miR-429/PDGFD pathway may play a regulatory role in the progression and prognosis of gastric cancer by interfering with the tumor microenvironment, and the PDGFD-related immune-gene signature could be considered a moderator of prognostic factor for gastric cancer and to guide immunotherapy programs." 2 circSTRN3 aggravates sepsis-induced acute kidney injury by regulating miR-578/ toll like receptor 4 axis. hsa_circ_010157 hsa_circ_STRN3 circSTRN3 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated "These results indicate that circSTRN3 upregulation in sepsis-induced AKI modulates miR-578/TLR4 axis to promote the pathogenesis of AKI, which could serve as future therapeutic targets for AKI treatment." 1 Circular RNA PUM1 performs as a competing endogenous RNA of microRNA-340-5p to mediate DEAD-box helicase 5 to mitigate cerebral ischemia-reperfusion injury. - mmu_circ_PUM1 circPUM1 DOID:326 ischemia Cerebral ischemia-reperfusion "RT-qPCR, RNA-seq" up-regulated this study clarifies that circPUM1 mitigates cerebral ischemia-reperfusion-induced neuronal injury by targeting the microRNA-340-5p/DEAD-box helicase 5 axis. 1 EIF4A3-regulated circ_0087429 can reverse EMT and inhibit the progression of cervical cancer via miR-5003-3p-dependent upregulation of OGN expression. hsa_circ_0087429 - circ_0087429 DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated "As a tumour suppressor, circ_0087429 regulated by EIF4A3 can reverse EMT and inhibit the progression of cervical cancer through the miR-5003-3p/OGN axis. It is expected to become a potential target for the treatment of cervical cancer." 1 Circular RNA SMARCA5 inhibits gastric cancer progression through targeting the miR-346/ FBXL2 axis. - hsa_circ_SMARCA5 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated circSMARCA5 exhibited a tumor suppressor-like activity in gastric cancer via regulating the miR-346/FBXL2 axis. 2 The potential role of circRNA_004229 in hair/epidermal regulation after MED1 ablation in keratinocytes. - - circRNA_004229 DOID:421 hair disease hair/epidermal regulation RT-qPCR down-regulated "Our study determined the expression profile of circRNAs in MED1 KO skin, and provided hints that circRNA_004229 might be involved in the regulation of keratinocytes in both hair follicles and interfollicular epidermis through a ceRNA mechanism." 1 Knockdown of circPVT1 inhibits progression of papillary thyroid carcinoma by sponging miR-126. - hsa_circ_PVT1 circPVT1 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated CircPVT1 knockdown inhibited PTC progression by sponging miR-126. 2 Anesthetic propofol suppresses growth and metastasis of lung adenocarcinoma in vitro through downregulating circ-MEMO1-miR-485-3p-NEK4 ceRNA axis. - hsa_circ_MEMO1 circ-MEMO1 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "Promoting the circ-MEMO1-miR-485-3p-NEK4 axis might halt the tumor-inhibiting role of propofol in LUAD cells in vitro, suggesting a potential epigenetic pathway of propofol." 1 The transcription factor ZEB1 mediates the progression of epithelial ovarian cancer by promoting the transcription of CircANKRD17. hsa_circ_0007883 hsa_circ_ANKRD17 CircANKRD17. DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Highly expressed ZEB1 promoted proliferation, invasion, migration, and EMT while it inhibited cell apoptosis in EOC by promoting the transcription of CircANKRD17, providing a potential target for the treatment of EOC." 2 "Hsa_circ_0023984 Regulates Cell Proliferation, Migration, and Invasion in Esophageal Squamous Cancer via Regulating miR-1294/PI3K/Akt/c-Myc Pathway." hsa_circ_0023984 hsa_circ_NOX4 circ_0023984 DOID:1749 squamous cell carcinoma squamous cancer RT-qPCR up-regulated circ_0023984 upregulated the expression of p-Akt and c-Myc by repressing miR-1294. circ_0023984 facilitates the malignant biological behaviors of ESCC cells through inhibiting miR-1294 and activating PI3K/Akt/c-myc pathway. 1 circSPECC1 promotes bladder cancer progression via regulating miR-136-5p/GNAS axis. - hsa_circ_SPECC1 circSPECC1 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "In general, our study suggested that circSPECC1 contributed to the growth and metastasis of Bca and it is possible to become an ideal non-invasive biomarker for diagnosis and effective therapeutic target for treatment." 1 CircRTN4 aggravates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis. hsa_circ_0054595 hsa_circ_RTN4 CircRTN4 DOID:0080162 lupus nephritis lupus nephritis RT-qPCR up-regulated Our findings indicated that circRTN4 exacerbates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis. 1 Circ_0005231 promotes the progression of esophageal squamous cell carcinoma via sponging miR-383-5p and regulating KIAA0101. hsa_circ_0005231 - Circ_0005231 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "Circ_0005231 acted as a sponge of miR-383-5p to promote ESCC progression by upregulating KIAA0101, which provided a potential therapeutic strategy for ESCC treatment." 1 M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma. - hsa_circ_MDK circMDK DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated CircMDK could serve as a potential tumor biomarker that promotes the progression of HCC via the miR-346/874-3p-ATG16L1 axis. The PAE-based delivery of siRNA improved the stability and efficiency of siRNA targeting circMDK. The PAE-siRNA nanoparticles effectively inhibited HCC proliferation and metastasis in vivo. Our current findings offer a promising nanotherapeutic strategy for the treatment of HCC. 1 Circular RNA circVAMP3 promotes aerobic glycolysis and proliferation by regulating LDHA in renal cell carcinoma. - hsa_circ_VAMP3 circVAMP3 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "Therefore, this study reveals a novel molecular mechanism by which circVAMP3 promotes glycolysis and proliferation through regulating the enzymatic activity of glycolytic enzyme, suggesting that circVAMP3 may represent an RCC biomarker and treatment target." 1 The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis. - hsa_circ_HMGB2 circHMGB2 DOID:1324 lung cancer lung adenocarcinomas (LUAD) and squamous cell carcinomas (LUSC). RT-qPCR up-regulated circHMGB2 overexpression promotes the LUAD and LUSC progression mainly by reshaping the tumor microenvironment and regulating anti-PD-1 resistance in the LUAD and LUSC patients. This study provides a new strategy for the LUAD and LUSC treatment. 1 "Circ_0093887 regulated ox-LDL induced human aortic endothelial cells viability, apoptosis, and inflammation through modulating miR-758-3p/BAMBI axis in atherosclerosis." hsa_circ_0093887 - circ_0093887 DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated Circ_0093887 demonstrated its diagnostic and therapeutic value in AS by promoting the role of the miR-758-3p/BAMBI axis in the ox-LDL-induced endothelial injury of HAECs. 2 "hsa_circ_0000523/miR-let-7b/METTL3 axis regulates proliferation, apoptosis and metastasis in the HCT116 human colorectal cancer cell line." hsa_circ_0000523 hsa_circ_METTL3 circ_0000523 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated The present results suggest that circRNAs and_ETTL3_ay be applied for highly sensitive diagnosis of CRC and for predicting prognosis in patients who have undergone therapy. 4 Circular RNA ERBIN Promotes Proliferation of Hepatocellular Carcinoma via the miR-1263/CDK6 Axis. - hsa_circ_ERBIN circERBIN DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Taken together, these results determined that circERBIN functions as an important epigenetic regulator in HCC development, highlighting that circERBIN is a promising target for treatment of HCC." 1 Icariin inhibits gastric cancer cell growth by regulating the hsa_circ_0003159/miR-223-3p/NLRP3 signaling axis. hsa_circ_0003159 hsa_circ_CACNA2D1 circ_0003159 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "In conclusion, this study indicated ICA inhibits GC cell growth by regulating the hsa_circ_0003159/miR-223-3p/NLRP3 signaling axis. This study not only reveals the mechanism of gastric carcinogenesis but also provides potential molecular targets and therapeutic tools for its treatment." 3 CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis. - hsa_circ_USP36 CircUSP36 DOID:6713 cerebrovascular disease ischemic stroke RT-qPCR down-regulated "In summary, we reveal for the first time that circUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis, which make circUSP36 a potential therapeutic target for IS." 1 Hsa_circ_0001495 contributes to cervical cancer progression by targeting miR-526b-3p/TMBIM6/mTOR axis. hsa_circ_0001495 hsa_circ_CCNB1 circ_0001495 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In summary, hsa_circ_0001495 regulated the progression of CC by regulating miR-526b-3p/TMBIM6/mTOR pathway." 2 FMRP ligand circZNF609 destabilizes RAC1 mRNA to reduce metastasis in acral melanoma and cutaneous melanoma. - hsa_circ_ZNF609 circZNF609 DOID:1909 melanoma melanoma RT-qPCR down-regulated "Our findings revealed that circZNF609 plays a vital role in the metastasis of acral and cutaneous melanoma through the circRNF609-FMRP-RAC1 axis and indicated that circZNF609 regulates the stability of RAC1 mRNA by combining with FMRP, which might provide insight into melanoma pathogenesis and a new potential target for treatment of melanoma." 1 Hsa_circ_0000285 contributes to gastric cancer progression by upregulating FN1 through the inhibition of miR-1278. hsa_circ_0000285 hsa_circ_HIPK3 circ_0000285 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "The hsa_circ_0000285/miR-1278/FN1 axis regulated GC progression. In addition, it may serve as a potential therapeutic biomarker for GC." 6 Hsa_circ_0003748 promotes disease progression in rheumatic valvular heart disease by sponging miR-577. hsa_circ_0003748 hsa_circ_IP6K2 circ_0003748 DOID:50827 rheumatic heart disease rheumatic valvular heart disease "RT-qPCR, microarray" dysregulated "Bioinformatic analysis revealed that hsa_circ_0003748 might affect RVHD progression by affecting transcription and the MAPK signaling pathway, the Ras signaling pathway, the cAMP signaling pathway, the Rap1 signaling pathway, and other signaling pathways." 1 "CircKCNQ5 controls proliferation, migration, invasion, apoptosis, and glycolysis of multiple myeloma cells by modulating miR-335-5p/BRD4 axis." - hsa_circ_KCNQ5 CircKCNQ5 DOID:9538 multiple myeloma myeloma RT-qPCR up-regulated CircKCNQ5 was found to stimulate MM progression through competitively sponging to miR-335-5p. 2 A novel protein encoded by ZCRB1-induced circHEATR5B suppresses aerobic glycolysis of GBM through phosphorylation of JMJD5. - hsa_circ_HEATR5B circHEATR5B DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "This study reveals a novel mechanism of regulating aerobic glycolysis and proliferation in GBM cells through the ZCRB1/circHEATR5B/HEATR5B-881aa/JMJD5/PKM2 pathway, which can provide novel strategies and potential targets for GBM therapy." 1 Hsa_circ_0000497 and hsa_circ_0000918 contributed to peritoneal metastasis of ovarian cancer via ascites. hsa_circ_0000497 hsa_circ_SLAIN1 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated circRNAs (hsa_circ_0000497 and hsa_circ_0000918) contribute to metastasis of EOC via ascites by regulating EMT. These circRNAs may serve as novel potential therapeutic targets or prognostic biomarkers for EOC peritoneal metastasis. 2 Hsa_circ_0000497 and hsa_circ_0000918 contributed to peritoneal metastasis of ovarian cancer via ascites. hsa_circ_0000918 hsa_circ_SLAIN1 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated circRNAs (hsa_circ_0000497 and hsa_circ_0000918) contribute to metastasis of EOC via ascites by regulating EMT. These circRNAs may serve as novel potential therapeutic targets or prognostic biomarkers for EOC peritoneal metastasis. 2 Knockdown of circRNA circEBF1 inhibits cutaneous squamous cell carcinoma progression by regulating the miR-1247-5p/CSF3 axis. - hsa_circ_EBF1 circEBF1 DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma RT-qPCR up-regulated "Down-regulation of circEBF1 impeded CSCC progression by regulating the miR-1247-5p/CSF3 pathway, suggesting that circEBF1 might be a promising therapeutic target for CSCC." 1 "Circular RNA circRNA-0039459 promotes the migration, invasion, and proliferation of liver cancer cells through the adsorption of miR-432." hsa_circ_0039459 - circ-0039459 DOID:3571 liver cancer liver cancer RT-qPCR up-regulated "Hence, circ-0039459 can affect the proliferation, apoptosis, migration, and invasion of hepatocellular carcinoma cells through the adsorption of miR-432, thereby regulating the expression of SYVN1." 1 Propofol modulates glycolysis reprogramming of ovarian tumor via restraining circular RNA-zinc finger RNA-binding protein/microRNA-212-5p/superoxide dismutase 2 axis. - hsa_circ_ZFR circ-ZFR DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "In short, Pro restrained glycolysis via mediating the circ-ZFR/miR-212-5p/SOD2 axis. These results offered a better theoretical foundation for comprehending the molecular pathology of OC and provided a novel target for OC diagnosis and treatment." 1 "A novel circRNA, circRACGAP1, hampers the progression of systemic lupus erythematosus via miR-22-3p-mediated AKT signalling." - hsa_circ_RACGAP1 circRACGAP1 DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR down-regulated "Collectively, circRACGAP1 regulated the AKT signalling pathway_ia_inding to miR-22-3p in the progression of SLE, suggesting therapeutic targets for SLE treatment." 1 "Hsa_circ_0000345 inhibits cell proliferation, migration and invasion of nasopharyngeal carcinoma cells via miR-513a-3p/PTEN axis." hsa_circ_0000345 hsa_circ_RSF1 circ_0000345 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR down-regulated "Hsa_circ_0000345 inhibits cell proliferation, migration and invasion of NPC cells via miR-513a-3p/PTEN axis, thereby suppressing the progression of NPC. Thus, this work suggests that hsa_circ_0000345 may be a potential biomarker for diagnosis and treatment of NPC." 1 "Circular RNA circ_0006089 regulates the IGF1R expression by targeting miR-143-3p to promote gastric cancer proliferation, migration and invasion." hsa_circ_0006089 - circ_0006089 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Circ_0006089 is highly expressed in GC, and it promotes the malignancy of GC cells via modulating miR-143-3p/IGF1R axis, suggesting that circ_0006089 may serve as a promising therapeutic target for GC." 4 Circ 003390/Eukaryotic translation initiation factor 4A3 promoted cell migration and proliferation in endometrial cancer via vascular endothelial growth factor signaling by miR-195-5p. - hsa_circ_WEE1 circWEE1 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "Our findings indicate that Circular RNA hsa circWEE1/EIF4A3 promoted cell migration and proliferation in EC via VEGF signaling by miR-195-5p, which could provide pivotal potential therapeutic targets for the treatment of EC." 1 Exosomal RNA Expression Profiles and Their Prediction Performance in Patients With Gestational Diabetes Mellitus and Macrosomia. - - Exosomal RNA DOID:9351 diabetes mellitus gestational diabetes mellitus and macrosomia "RT-qPCR, microarray" dysregulated These results showed that exosomal RNAs are aberrantly expressed in the cord blood of patients with GDM-M and highlighted the importance of exosomal RNAs in peripheral blood for GDM-M prediction. 1 Circular RNA_0120376 regulates microRNA-148b-3 and centrosomal protein 55 to promote non-small cell lung cancer development. hsa_circ_0120376 - circ_0120376 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "In summary, circ_0120376 contributes to the malignancy of NSCLC cells through a ceRNA mechanism via regulating miR-148b-3p/CEP55 axis. Circ_0120376 is likely to be a potential diagnostic biomarker and therapeutic target for NSCLC." 1 Circular RNA from phosphodiesterase 4D can attenuate chondrocyte apoptosis and matrix degradation under OA milieu induced by IL-1beta via circPDE4D/miR-4306/SOX9 Cascade. hsa_circ_0072568 hsa_circ_PDE4D circPDE4D DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "CircPDE4D and miR-4306 were important regulators in regulating IL-1beta-induced HNC apoptosis and matrix degradation via regulating the key transcription factor SOX9, suggesting a novel circPDE4D/miR-4306/SOX9 ceRNA pathway in OA-related chondrocyte dysfunction." 2 "Circular_0086414 induces SPARC like 1 (SPARCL1) production to inhibit esophageal cancer cell proliferation, invasion and glycolysis and induce cell apoptosis by sponging miR-1290." hsa_circ_0086414 - Circular_0086414 DOID:5041 esophageal cancer esophageal cancer RT-qPCR down-regulated "Thus, circ_0086414 inhibited EC cell malignancy through the miR-1290/SPARCL1_athway, providing a reliable target for the therapy of EC." 1 Hsa_circ_0103232 promotes melanoma cells proliferation and invasion via targeting miR-661/RAB3D. hsa_circ_0103232 hsa_circ_OCA2 circ_0103232 DOID:1909 melanoma melanoma RT-qPCR up-regulated Hsa_circ_0103232 is a tumor promoter in melanoma to enhance malignant phenotype and growth in vivo via sponging miR-661/RAB3D. Hsa_circ_0103232 may be a novel target for melanoma treatment. 1 CircRNA protein tyrosine phosphatase receptor type a suppresses proliferation and induces apoptosis of lung adenocarcinoma cells via regulation of microRNA-582-3p. - hsa_circ_PTPRA circRNA_PTPRA DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated These findings demonstrate that the up-regulation of circRNA_PTPRA significantly reduces lung cancer cell proliferation and induces apoptosis by regulating miR-582-3p expression. 1 Plasma circRNA microarray profiling identifies novel circRNA biomarkers for the diagnosis of ovarian cancer. Hsa_circ_0003972 - Hsa_circ_0003972 and hsa_circ_0007288 DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, microarray" down-regulated Our results revealed that hsa_circ_0003972 and hsa_circ_0007288 may serve as novel circulating biomarkers for ovarian cancer diagnosis. 1 Circ_0000514 promotes the malignant biological behaviors of non-small cell lung cancer cells by modulating miR-330-5p and HMGA2. hsa_circ_0000514 - Circ_0000514 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0000514 is an oncogenic circRNA in NSCLC progression, and it modulates miR-330-5p/HMGA2 axis." 1 Circ-TLR4 promotes cardiac hypertrophy through recruiting FUS to stabilize TLR4 mRNA. - hsa_circ_TLR4 Circ-TLR4 DOID:114 heart disease cardiac hypertrophy RT-qPCR up-regulated Circ-TLR4 promotes cardiac hypertrophy through recruiting FUS to stabilize TLR4 mRNA. 1 "Circ_0000775 promotes the migration, invasion and EMT of hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27." hsa_circ_0000775 - Circ_0000775 DOID:684 hepatocellular carcinoma hepatic carcinoma RT-qPCR up-regulated "TCF7L2 promoted the transcription of circ_0000775, and circ_0000775 recruited IGF2BP2 to maintain CDC27 mRNA stability, thereby facilitating HC cell migration, invasion and EMT." 1 "Circ_0001273 downregulation inhibits the growth, migration and glutamine metabolism of esophageal cancer cells via targeting the miR-622/SLC1A5 signaling axis." hsa_circ_0001273 - Circ_0001273 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated Circ_0001273 high expression contributed to EC progression via modulating the miR-622/SLC1A5 signaling axis. 1 CircZNF609 promotes bladder cancer progression and inhibits cisplatin sensitivity via miR-1200/CDC25B pathway. hsa_circ_0000615 hsa_circ_ZNF609 CircZNF609 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated This research reveals that circZNF609 improves bladder cancer progression and inhibits cisplatin sensitivity by inducing G1/S cell cycle arrest via a novel miR-1200/CDC25B cascades. 2. CircZNF609 was confirmed associated with worse survival of bladder cancer patients. 3. CircZNF609 act as a prognostic biomarker for bladder cancer treatment. 1 CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA. - hsa_circ_EIF3H CircEIF3H DOID:1612 breast cancer breast cancer RNA-seq up-regulated "Our findings provide insight into a novel circRNA, circEIF3H, with significant cancer-promoting function via serving as a scaffold for IGF2BP2/HuR. These results identified circEIF3H as a potential target for developing individualized therapy of TNBC in the approaching future." 1 Circ_0000274 contributes to renal cell carcinoma progression by regulating miR-338-3p/NUCB2 axis and JAK1/STAT3 pathway. hsa_circ_0000274 - Circ_0000274 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated Circ_0000274 RNA functioned as an oncogene in RCC development by regulating miR-338-3p RNA/NUCB2 protein axis and activating the JAK1/STAT3 protein signaling pathway. 1 Circ_0000291 contributes to hepatocellular carcinoma tumorigenesis by binding to miR-1322 to up-regulate UBE2T. hsa_circ_0000291 - Circ_0000291 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0000291 facilitated HCC progression by targeting miR-1322/UBE2T axis, which provided novel potential biomarkers and targets for HCC patients." 1 Circ_0124644 enhances ox-LDL-induced cell damages in human umbilical vein endothelial cells through upregulating FOXO4 by sponging miR-370-3p. hsa_circ_0124644 - Circ_0124644 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated All results revealed that circ_0124644 accelerated endothelial injury in ox-LDL-treated HUVECs by mediating miR-370-3p-related FOXO4 expression. 2 Circular RNA (circ)_0129047 upregulates bone morphogenetic protein receptor type 2 expression to inhibit lung adenocarcinoma progression by sponging microRNA (miR)-1206. hsa_circ_0129047 - circ_0129047 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated "In conclusion, circ _0129047 was found to play a tumor suppressive role in LAC progression; it upregulated BMPR2 expression to inhibit LAC progression by sponging miR-1206.." 2 A Circ-0007022/miR-338-3p/Neuropilin-1 Axis Reduces the Radiosensitivity of Esophageal Squamous Cell Carcinoma by Activating Epithelial-To-Mesenchymal Transition and PI3K/AKT Pathway. hsa_circ_0007022 - Circ-0007022 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "Taken together, the circ-0007022/miR-338-3p/NRP1 axis enhances the radiation resistance of ESCC cells_ia_egulating EMT and PI3K/Akt pathway. The new circRNA circ-0007022 is thus expected to be a therapeutic target for ESCC patients." 1 circPTP4A2-miR-330-5p-PDK2 Signaling Facilitates In Vivo Survival of HuMSCs on SF-SIS Scaffolds and Improves the Repair of Damaged Endometrium. - hsa_circ_PTP4A2 circPTP4A2-miR-330-5p-PDK2 DOID:13812 adhesions of uterus adhesions of uterus "RT-qPCR, RNA-seq" up-regulated "We demonstrated that circPTP4A2 was elevated in HuMSCs-seeded on SF-SIS scaffolds and stabilized the mitochondrial metabolism through miR-330-5p-PDK2 signaling, which contributes to endometrial repair progression. These findings demonstrate that HuMSCs-seeded SF-SIS scaffolds have potential for the treatment of IUA." 1 circHtra1/miR-3960/GRB10 Axis Promotes Neuronal Loss and Immune Deficiency in Traumatic Brain Injury. - hsa_circ_Htra1 circHtra1 DOID:81292 traumatic brain injury raumatic Brain Injury "RT-qPCR, microarray" up-regulated "Our results show that circHtra1 promotes neuronal loss by sponging miR-3960 and regulating GRB10 and apoptosis during brain insults. In addition, A-to-I editing could regulate circRNA expression profiles after TBI, and circHtra1 is a potential therapeutic target." 1 circZNF91 Promotes the Malignant Phenotype of Chronic Lymphocytic Leukemia Cells by Targeting the miR-1283/WEE1 Axis. - hsa_circ_ZNF91 circZNF91 DOID:1040 chronic lymphocytic leukemia chronic lymphocytic leukemia RT-qPCR up-regulated "The circZNF91/miR-1283/WEE1 axis is engaged in the pathological phenotypes of CLL cells, which could serve as potential targets for future therapy development." 1 Bioinformatics Study Revealed Significance of Exosome Transcriptome in Hepatocellular Carcinoma Diagnosis. - - Exosome Transcriptome DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" dysregulated This study discovered atypical signature exosomes for HCC prognostic prediction based on an online database. The signals could mimic exosome microenvironmental disorders providing potential biomarkers for exosome treatment. 1 CircRNA has_circ_0069313 induced OSCC immunity escape by miR-325-3p-Foxp3 axes in both OSCC cells and Treg cells. hsa_circ_0069313 hsa_circ_PACRGL - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated has_circ_0069313 induces OSCC immunity escape via the miR-325-3p-Foxp3 axis in both OSCC cells and Treg cells. 1 "Hsa_circ_0001982 promotes the proliferation, invasion, and multidrug resistance of osteosarcoma cells." hsa_circ_0001982 hsa_circ_RNF111 circ_0001982 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "The regulation of malignant behaviors such as proliferation, invasion, migration, and multidrug resistance of OS cells by hsa_circ_0001982 may be achieved by targeting miR-143. Moreover, hsa_circ_0001982 is a potential target for early diagnosis and targeted therapy of OS." 1 "circ_0004872 inhibits proliferation, invasion, and glycolysis of oral squamous cell carcinoma by sponged miR-424-5p." hsa_circ_0004872 hsa_circ_MAPK1 circ_0004872 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "circ_0004872 suppresses the proliferation, invasion, and glycolysis of OSCC cells by sponged miR-424-5p, and promotes apoptosis." 1 Mechanism of circHIPK3-miRNA-124-3p/miRNA-148b-3p-Mediated Inflammatory Responses and Cell Senescence in Candida albicans-Induced Septic Acute Kidney Injury. - hsa_circ_HIPK3 - DOID:557 kidney disease septic acute kidney injury RT-qPCR up-regulated circHIPK3 aggravated SAKI inflammatory responses via miR-124-3p/KLF6 and accelerated SAKI cell senescence via miR-148b-3p/DNMT1/3a. 3 circHIPK3 regulates apoptosis and mitochondrial dysfunction induced by ischemic stroke in mice by sponging miR-148b-3p via CDK5R1/SIRT1. - mmu_circ_HIPK3 circHIPK3 DOID:6713 cerebrovascular disease ischemic stroke RNA-seq up-regulated "circHIPK3 functions as an endogenous sponge of miR-148b-3p to decrease its activity, resulting in upregulation of CDK5R1 and CDK5 expression, downregulation of SIRT1 expression and subsequent BMEC apoptosis and mitochondrial dysfunction." 1 CircPCBP2 promotes the stemness and chemoresistance of DLBCL via targeting miR-33a/b to disinhibit PD-L1. - hsa_circ_PCBP2 CircPCBP2 DOID:0050745 diffuse large B-cell lymphoma diffuse large B-cell lymphoma RT-qPCR up-regulated circPCBP2 enhances DLBCL cell stemness but suppresses its sensitivity to CHOP via sponging miR-33a/b to disinhibit PD-L1 expression. 1 CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11. - hsa_circ_KIF4A CircKIF4A DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circKIF4A enhanced OS growth as well as metastasis by sponging miR-515-5p and by upregulating SLC7A11. 1 CircATIC Contributes to Multiple Myeloma Progression via miR-324-5p-Dependent Regulation of HGF. hsa_circ_0058058 hsa_circ_ATIC CircATIC DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated "CircATIC accelerated the proliferation, migration, invasion, and glycolysis and suppressed the apoptosis of MM cells through mediating miR-324-5p/HGF signaling." 2 Circ_0006404 enhances hepatocellular carcinoma progression by regulating miR-624. hsa_circ_0006404 - Circ_0006404 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circ_0006404 induced HCC cell growth, cycle, and migration via regulating miR-624." 1 Eriodictyol inhibits breast carcinogenesis by targeting circ_0007503 and repressing PI3K/Akt pathway. hsa_circ_0007503 - circ_0007503 DOID:1612 breast cancer breast cancer RT-qPCR dysregulated eriodictyol could effectively suppress breast carcinogenesis in vitro and in vivoThe mechanism may be attributed to targeting circ_0007503 and inhibiting PI3K/Akt pathway. 1 Circ_0003423 Alleviates Oxidized Low-Density Lipoprotein-Induced Endothelial Cell Injury by Sponging miR-142-3p and Activating Sirtuin 3/Superoxide Dismutase 2 Pathway. hsa_circ_0003423 - Circ_0003423 DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated "Circ_0,003,423 protected HUVECs from ox-LDL-induced dysfunction by sponging miR-142-3p and activating SIRT3/SOD2 signaling." 1 Circ_0000284 Promoted Acute Pancreatitis Progression through the Regulation of miR-10a-5p/Wnt/beta-Catenin Pathway. hsa_circ_0000284 - Circ_0000284 DOID:2913 acute pancreatitis acute pancreatitis RT-qPCR up-regulated Circ_0000284 depletion could protect caerulein-induced AR42J cells from apoptosis and inflammation by upregulating miR-10a-5p expression and activating Wnt/beta-catenin pathway. 1 CircLIFR suppresses hepatocellular carcinoma progression by sponging miR-624-5p and inactivating the GSK-3beta/beta-catenin signaling pathway. - hsa_circ_LIFR CircLIFR DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated circLIFR acts as a tumor suppressor in HCC by regulating miR-624-5p and inactivating the GSK-3beta/beta-catenin signaling pathway. 2 Circular RNA circPFKP suppresses the proliferation and metastasis of gastric cancer cell via sponging miR-644 and regulating ADAMTSL5 expression. - hsa_circ_PFKP CircPFKP DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated the circPFKP/miR-644/ADAMTSL5 regulatory pathway inhibited the malignant progression of GC. 1 circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/alpha-syn pathway in Parkinson disease. - mmu_circ_Pank1 circ-Pank1 DOID:14330 Parkinson disease Parkinson disease RT-qPCR up-regulated circ-Pank1 is overexpressed in PD and enhances the locomotor dysfunction via the miR-7a-5p/alpha-syn signaling axis. 1 "Knockdown of Circ_0003506 Impedes Radioresistance, Cell Growth, Migration and Invasion in Gastric Cancer." hsa_circ_0003506 - Circ_0003506 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Knockdown of circ_0003506 suppressed radioresistance in GC through the regulation of miR-1256/bone morphogenetic protein type 2 receptor axis. 2 Circ-RHOJ1 regulated myocardial cell proliferation and apoptosis via targeting the miR-124-3p/NRG-1 axis in myocardial ischemia/reperfusion injury. - rno_circ_RHOJ.1 circRHOJ.1 DOID:1287 cardiovascular system disease myocardial ischemia-reperfusion injury RT-qPCR down-regulated Circ-RHOJ.1 served as a molecular marker of myocardial I/R injury via regulation of miR-124-3p and NRG1 expression. 1 "CircFGGY Inhibits Cell Growth, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma via Regulating the miR-545-3p/Smad7 Axis." hsa_circ_0006633 hsa_circ_FGGY CircFGGY DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated circFGGY inhibits the proliferation and invasion of HCC cells by sponging miR-545-3p and promote the expression of Smad7. 1 CircERBB2IP promotes post-infarction revascularization via the miR-145a-5p/Smad5 axis. - mmu_circ_ERBB2IP CircERBB2IP DOID:5844 myocardial infarction myocardial Infarction RT-qPCR up-regulated circERBB2IP can promote angiogenesis after myocardial infarction through the miR-145a-5p/Smad5 axis. 1 "CircKIAA0368 Promotes Proliferation, Migration, and Invasion by Upregulating HOXA10 in Nasopharyngeal Carcinoma." - hsa_circ_KIAA0368 CircKIAA0368 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "CircKIAA0368 upregulates HOXA10 expression via miR-6838-5p and PCAF, consequently promoting NPCcell and tumor growth." 1 M2 macrophage facilitated angiogenesis in cutaneous squamous cell carcinoma via circ_TNFRSF21/miR-3619-5p/ROCK axis. - hsa_circ_TNFRSF21 circ_TNFRSF21 DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma RT-qPCR up-regulated circ_TNFRSF21 was elevated in M2 macrophages and mediated M2 macrophage-induced tube formation in vitro. 1 Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer. - hsa_circ_TICRR circTICRR DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" up-regulated circTICRR acts as an oncogene in cervical cancer and the interaction between circTICRR and HuR protein may be a potential target in cervical cancer therapeutics. 1 Circ_0039960 regulates growth and Warburg effect of breast cancer cells via modulating miR-1178/PRMT7 axis. hsa_circ_0039960 - Circ_0039960 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circ_0039960 regulates cell growth and Warburg effect in BC cells via miR-1178/PRMT7 axis. 1 The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the malignant behaviors of papillary thyroid carcinoma cells. - hsa_circ_FAM53B circ_FAM53B DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR down-regulated circ_FAM53B affects PTC cell biological behaviors via the miR-183-5p-CCDC6 axis. 1 Oxidized low-density lipoprotein contributes to injury of endothelial cells via the circ_0090231/miR-9-5p/TXNIP axis. hsa_circ_0090231 - circ_0090231 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Circ_0090231 could attenuate ox-LDL-mediated HUVEC damage by the miR-9-5p/TXNIP axis. 2 "The Expression Profile, Clinical Application and Potential Tumor Suppressing Mechanism of hsa_circ_0001675 in Head and Neck Carcinoma." hsa_circ_0001675 hsa_circ_C1GALT1 circ_0001675 DOID:1542 head and neck carcinoma head and neck carcinoma "RT-qPCR, RNA-seq" down-regulated hsa_circ_0001675 is downregulated in HNC and could be an effective biomarker for HNC diagnosis. 1 "Circ_0001998 Regulates the Proliferation, Invasion, and Apoptosis of Lung Adenocarcinoma via Sponging miR-145." hsa_circ_0001998 - Circ_0001998 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "Circ_0001998 regulates the proliferation, invasion, and apoptosis of LUAD via sponging miR-145." 1 hsa_circ_0001955 Promotes Colorectal Cancer Progression by Regulating miR-583/FGF21 Axis. hsa_circ_0001955 hsa_circ_CSNK1G1 circ_0001955 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated hsa_circ_0001955 facilitated CRC progression via miR-583/FGF21 axis. 2 CircNMD3 relieves endothelial cell injury induced by oxidatively modified low-density lipoprotein through regulating miR-498/ BMP and activin membrane-bound inhibitor (BAMBI) axis. - hsa_circ_NMD3 CircNMD3 DOID:1936 atherosclerosis atherosclerosis RT-qPCR dysregulated "circNMD3 regulates the level of miR-498, which in turn modulates BAMBI expression and suppresses ox-LDL-induced injury in HUVECs." 2 "The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease." hsa_circ_0008882 - circ_0008882 DOID:850 lung disease chronic respiratory disease RT-qPCR down-regulated the relative expression of circ_0008882 was decreased after copper exposure in vitro and in vivo. 1 Oxymatrine induces anti-tumor response in cervical cancer by modulating circ_0008460/miR-197-3p/ribonucleotide reductase subunit M2 (RRM2). hsa_circ_0008460 - circ_0008460 DOID:4362 cervical cancer cervical cancer RT-qPCR dysregulated OMT restrained CC cell progression in vitro and tumor growth in vivo by downregulating circ_0008460 to mediate miR-197-3p/RRM2 axis. 1 Circular RNA_0001187 participates in the regulation of ulcerative colitis development via upregulating myeloid differentiation factor 88. hsa_circ_0001187 - circ_0001187 DOID:8577 ulcerative colitis ulcerative colitis RT-qPCR up-regulated circ_0001187 facilitated UC progression through miR-1236-3p/MYD88 axis. 1 "CircSLC8A1 targets miR-181a-5p/HIF1AN pathway to inhibit the growth, migration and extracellular matrix deposition of human keloid fibroblasts." - hsa_circ_SLC8A1 CircSLC8A1 DOID:10881 "hand, foot and mouth disease" keloid RT-qPCR down-regulated circSLC8A1 regulates the miR-181a-5p/HIF1AN axis to restrain HKFs biological functions. 1 Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer. - - hsa_circRNA_100833 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "6 circRNAs showed high diagnostic values (AUC = 0.6860, AUC = 0.8127, AUC = 0.7502, AUC = 0.9945, AUC = 0.9642, AUC = 0.9486 for hsa_circRNA_100833, hsa_circRNA_103828, hsa_circRNA_103831 and hsa_circRNA_103752, hsa_circRNA_071106, hsa_circRNA_102293)." 1 Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer. - - hsa_circRNA_103828 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "6 circRNAs showed high diagnostic values (AUC = 0.6860, AUC = 0.8127, AUC = 0.7502, AUC = 0.9945, AUC = 0.9642, AUC = 0.9486 for hsa_circRNA_100833, hsa_circRNA_103828, hsa_circRNA_103831 and hsa_circRNA_103752, hsa_circRNA_071106, hsa_circRNA_102293)." 1 Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer. - - hsa_circRNA_103831 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "6 circRNAs showed high diagnostic values (AUC = 0.6860, AUC = 0.8127, AUC = 0.7502, AUC = 0.9945, AUC = 0.9642, AUC = 0.9486 for hsa_circRNA_100833, hsa_circRNA_103828, hsa_circRNA_103831 and hsa_circRNA_103752, hsa_circRNA_071106, hsa_circRNA_102293)." 1 Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer. - - hsa_circRNA_103752 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" down-regulated "6 circRNAs showed high diagnostic values (AUC = 0.6860, AUC = 0.8127, AUC = 0.7502, AUC = 0.9945, AUC = 0.9642, AUC = 0.9486 for hsa_circRNA_100833, hsa_circRNA_103828, hsa_circRNA_103831 and hsa_circRNA_103752, hsa_circRNA_071106, hsa_circRNA_102293)." 1 Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer. - - hsa_circRNA_071106 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" down-regulated "6 circRNAs showed high diagnostic values (AUC = 0.6860, AUC = 0.8127, AUC = 0.7502, AUC = 0.9945, AUC = 0.9642, AUC = 0.9486 for hsa_circRNA_100833, hsa_circRNA_103828, hsa_circRNA_103831 and hsa_circRNA_103752, hsa_circRNA_071106, hsa_circRNA_102293)." 1 Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer. - - hsa_circRNA_102293 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" down-regulated "6 circRNAs showed high diagnostic values (AUC = 0.6860, AUC = 0.8127, AUC = 0.7502, AUC = 0.9945, AUC = 0.9642, AUC = 0.9486 for hsa_circRNA_100833, hsa_circRNA_103828, hsa_circRNA_103831 and hsa_circRNA_103752, hsa_circRNA_071106, hsa_circRNA_102293)." 1 Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer. hsa_circ_0000375 - circ_0000375 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated Circ_0000375 and circ_0011536 may function as tumor suppressors in CRC progression. 1 Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer. hsa_circ_0011536 - circ_0011536 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated Circ_0000375 and circ_0011536 may function as tumor suppressors in CRC progression. 1 "Circular RNA circLRCH3 Inhibits Proliferation, Migration, and Invasion of Colorectal Cancer Cells Through miRNA-223/LPP Axis." - hsa_circ_LRCH3 circLRCH3 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated circLRCH3/miR-223/LPP axis likely plays a critical role in CRC. 1 CircRNF220 plays a pathogenic role to facilitate cell progression of AML in vitro via sponging miR-330-5p to induce upregulation of SOX4. - hsa_circ_RNF220 CircRNF220 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated circRNF220 contributed to AML cell development in vitro via upregulating SOX4 expression by targeting miR-330-5p. 2 Knockout of circRNA single stranded interacting protein 1 (circRBMS1) played a protective role in myocardial ischemia-reperfusion injury though inhibition of miR-2355-3p/Mammalian Sterile20-like kinase 1 (MST1) axis. - hsa_circ_RBMS1 circRBMS1 DOID:1287 cardiovascular system disease myocardial ischemia-reperfusion injury RT-qPCR up-regulated circRBMS1 played a protective role in myocardial I/R injury though inhibition of miR-2355-3p/MST1 axis. 1 Circ_0014359 promotes oral squamous cell carcinoma progression by sponging miR-149. hsa_circ_0014359 - Circ_0014359 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated The circ_0014359-miR-149 pathway may be a novel target for developing strategies for the diagnosis and treatment of OSCC. 1 circ_000166/miR-296 Aggravates the Process of Diabetic Renal Fibrosis by Regulating the SGLT2 Signaling Pathway in Renal Tubular Epithelial Cells. - - circ_000166 DOID:0050855 renal fibrosis diabetic renal fibrosis RT-qPCR up-regulated circ_000166/miR-296/SGLT2 may become a new target in the progression of DN renal fibrosis. 1 Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1. - hsa_circ_ITGB1 circITGB1 DOID:9408 acute myocardial infarction acute myocardial Infarction "RT-qPCR, microarray" up-regulated "circITGB1 competitively binds to miR-342-3p and inhibits its expression, which in turn increase the expression of NFAT activating molecule 1 (NFAM1)." 1 "Hsa_circ_0006732 regulates colorectal cancer cell proliferation, invasion and EMT by miR-127-5p/RAB3D axis." hsa_circ_0006732 hsa_circ_ZDHHC20 circ_0006732 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated hsa_circ_0006732 might be an oncogene in CRC through the regulation of the miR-127-5p/RAB3D axis. 1 PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN. - hsa_circ_LHFPL2 circLHFPL2 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated Downregulation of circLHFPL2 sustains the activation of the PI3K/AKT signaling pathway via a positive feedback loop in PIK3CA-mutant CRC. 1 Circ_ROBO2/miR-186-5p/TRIM14 axis regulates oxidized low-density lipoprotein-induced cardiac microvascular endothelial cell injury. - hsa_circ_ROBO2 Circ_ROBO2 DOID:3393 coronary artery disease coronary artery disease RT-qPCR up-regulated Circ_ROBO2 played a promoting role in ox-LDL-induced CMECs injury by sponging miR-186-5p and regulating TRIM14. 2 CircPVT1 facilitates the progression of oral squamous cell carcinoma by regulating miR-143-3p/SLC7A11 axis through MAPK signaling pathway. - hsa_circ_PVT1 CircPVT1 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated circPVT1 impeded OSCC progression via the miR-143-3p/SLC7A11 axis through MAPK signaling pathway. 2 "The circSPON2/miR-331-3p axis regulates PRMT5, an epigenetic regulator of CAMK2N1 transcription and prostate cancer progression." - hsa_circ_SPON2 circSPON2 DOID:10283 prostate cancer prostate cancer RNA-seq dysregulated PRMT5 aggravates PCa progression by inhibiting the transcription of CAMK2N1 and is modulated by the circSPON2/miR-331-3p axis. 1 Hsa_circ_0006692 Promotes Lung Cancer Progression via miR-205-5p/CDK19 Axis. hsa_circ_0006692 hsa_circ_TCONS_00025531 circ_0006692 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "sa_circ_0006692 promoted NSCLC progression via enhancing cell growth, invasion, and metastasis through sponging mir-205-5p, up-regulating the downstream oncogene CDK19 and modulating EMT of lung cancer cells." 1 Circ_0008068 facilitates the oral squamous cell carcinoma development by microRNA-153-3p/acylgycerol kinase (AGK) axis. hsa_circ_0008068 - Circ_0008068 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated circ_0008068 expedited the growth of OSCC by miR-153-3p/AGK axis. 1 Circ_0066881 targets miR-144-5p/RORA axis to alleviate LPS-induced apoptotic and inflammatory damages in human periodontal ligament cells. hsa_circ_0066881 - Circ_0066881 DOID:824 periodontitis periodontitis RT-qPCR down-regulated circ_0066881 partly prevented LPS-evoked cell dysfunction in PDLCs through miR-144-5p-mediated up-regulation of RORA. 1 circNup188/miR-760-3p/Map3k8 axis regulates inflammation in cerebral ischemia. - hsa_circ_Nup188 circNup188 DOID:2316 brain ischemia cerebral ischemia RT-qPCR dysregulated "circNup188 might up-regulate Map3k8 expression through sponging miR-760-3p and then activate NF-kappaB pathway, which was involved in cerebral ischemia development." 1 Knockdown of circ_0026579 ameliorates lipopolysaccharide (bacterial origin)-induced inflammatory injury in bronchial epithelium cells by targeting miR-338-3p/TBL1XR1 axis. hsa_circ_0026579 - circ_0026579 DOID:12375 bronchopneumonia bronchopneumonia RT-qPCR up-regulated Circ_0026579 RNA knockdown promoted cell proliferation but inhibited apoptosis and inflammation in LPS-induced BEAS-2B cells through regulating miR-338-3p RNA/TBL1XR1 protein axis. 1 Glioblastoma-associated microglia-derived exosomal circKIF18A promotes angiogenesis by targeting FOXC2. - hsa_circ_KIF18A circKIF18A DOID:3073 brain glioblastoma multiforme glioblastoma multiforme RT-qPCR dysregulated M2 GAM-derived exosomal circKIF18A participating in GBM angiogenesis via targeting FOXC2. 1 "Circular RNA hsa_circ_0026344 suppresses gastric cancer cell proliferation, migration and invasion via the miR-590-5p/PDCD4 axis." hsa_circ_0026344 hsa_circ_ACVRL1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Circ_0026344 up-regulates PDCD4 expression via sponging miR-590-5p, thus inhibiting the progression of GC." 2 circRNA422 enhanced osteogenic differentiation of bone marrow mesenchymal stem cells during early osseointegration through the SP7/LRP5 axis. - - circRNA422 DOID:0080001 bone disease osteogenic differentiation RT-qPCR up-regulated circRNA422 could regulate early osseointegration in in vivo. 1 Exosomal circRNA BTG2 derived from RBP-J overexpressed-macrophages inhibits glioma progression via miR-25-3p/PTEN. - hsa_circ_BTG2 circBTG2 DOID:0060108 brain glioma glioma "RT-qPCR, microarray" dysregulated RBP-J OE Mphi inhibits tumor progression through the circBTG2/miR-25-3p/PTEN pathway. 1 CircRNA circ-MYBL2 absorbs precursor miR-92b in the nucleus to suppress its role in enhancing gastric cancer cell proliferation. - hsa_circ_MYBL2 Circ-MYBL2 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Circ-MYBL2 may absorb precursor miR-92b in the nucleus to suppress its role in promoting gastric cancer cell proliferation. 2 Circ-0002814 participates in proliferation and migration through miR-210 and FUS/VEGF pathway of preeclampsia. hsa_circ_0002814 - Circ-0002814 DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated A low expression of circ-0002814 was detected in the plasma and placental tissue in preeclampsia patients. circ-0002814 participated in the proliferation and invasion of HTR8 and JEG3 cells. 1 circRNA TCFL5 Promote Esophageal Cancer Progression by Modulating M2 Macrophage Polarization via the miR-543-FMNL2 Axis. - hsa_circ_TCFL5 circRNA TCFL5 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "circRNA TCFL5 was dramatically upregulated in esophageal cancer, and circRNA TCFL5 promotes esophageal cancer progression by modulating M2 macrophage polarization via the miR-543-FMNL2 axis." 1 CircNRIP1 Exerts Oncogenic Functions in Papillary Thyroid Carcinoma by Sponging miR-653-5p and Regulating PBX3 Expression. hsa_circ_0004771 hsa_circ_NRIP1 circ_0004771 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, RNA-seq" up-regulated Silencing of circNRIP1 suppressed PTC development via miR-653-5p elevation and PBX3 reduction. 2 Exosomal Circsafb2 Reshaping Tumor Environment to Promote Renal Cell Carcinoma Progression by Mediating M2 Macrophage Polarization. - hsa_circ_safb2 Circsafb2 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated circSAFB2 leads to immune escape from RCC by mediating M2 macrophage polarization via the miR-620/JAK1/STAT3 axis. 1 Silencing circular RNA-friend leukemia virus integration 1 restrained malignancy of CC cells and oxaliplatin resistance by disturbing dyskeratosis congenita 1. hsa_circ_0000370 hsa_circ_FLI1 circ-FLI1 DOID:219 colon cancer colon cancer RT-qPCR dysregulated circ-FLI1 might confer L-OHP resistance and malignant progression of CC presumably through the circ-FLI1/miR-197-3p/DKC1 ceRNA axis. 1 CircRIP2 aggravates the deterioration of colorectal carcinoma by negatively regulating CBFB. - hsa_circ_RIP2 CircRIP2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated CircRIP2 is a potential indicator for predicting tumor staging and distant metastasis of CRC. 1 CircPVT1 promotes the tumorigenesis and metastasis of osteosarcoma via mediation of miR-26b-5p/CCNB1 axis. - hsa_circ_PVT1 CircPVT1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Silencing of circPVT1 notably suppressed the tumorigenesis and metastasis of OS via miR-26b-5p/CCNB1 axis. 5 Circular RNA hsa_circ_0068252 Functions in Cisplatin Resistance and Immune Response via miR-1304-5p/PD-L1 Axis in Non-Small Cell Lung Cancer. hsa_circ_0068252 hsa_circ_PARL circ_0068252 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated The circ_0068252/miR-1304-5p/PD-L1 signal axis participates in the regulation of DDP resistance and immune escape of NSCLC cells. 1 Exosomal circ-CACNG2 promotes cardiomyocyte apoptosis in multiple myeloma via modulating miR-197-3p/caspase3 axis. - hsa_circ_CACNG2 circ-CACNG2 DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated MM-exosomes could inhibit cardiomyocyte viability and promote apoptosis partially through circ-CACNG2/miR-197-3p/caspase3 axis. 1 CircSLC8A1 Exacerbates Hypoxia-Induced Myocardial Injury via Interacting with MiR-214-5p to Upregulate TEAD1 Expression. - hsa_circ_SLC8A1 CircSLC8A1 DOID:5844 myocardial infarction myocardial infarction RT-qPCR up-regulated These results suggested that circSLC8A1 aggravated cell damages in hypoxia-treated cardiomyocytes by the regulation of TEAD1 via sponging miR-214-5p. 1 CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2. hsa_circ_0007905 hsa_circ_STX6 CircSTX6 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated circSTX6 facilitates proliferation and metastasis of PDAC cells by regulating the expression of MYH9 through the circSTX6/miR-449b-5p axis and circSTX6/CUL2/HIF1A signaling pathway. 1 circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA. - hsa_circ_PDE5A circPDE5A DOID:10283 prostate cancer prostate cancer microarray down-regulated FOXO4-mediated upregulation of circPDE5A controls PCa metastasis via the circPDE5A-WTAP-EIF3C-MAPK signaling pathway. 1 The molecular mechanism of circRHOBTB3 inhibits the proliferation and invasion of epithelial ovarian cancer by serving as the ceRNA of miR-23a-3p. - hsa_circ_RHOBTB3 circRHOBTB3 DOID:2394 ovarian cancer ovarian cancer RT-qPCR dysregulated "circRHOBTB3 could serve as the ceRNA of miR_23a-3p to facilitate PTEN expression, suppress proliferation, G1/S transition, invasion, and promote apoptosis in EOC." 2 CircSCAF8 promotes growth and metastasis of prostate cancer through the circSCAF8-miR-140-3p/miR-335-LIF pathway. - hsa_circ_SCAF8 CircSCAF8 DOID:10283 prostate cancer prostate cancer RNA-seq up-regulated circSCAF8 contributes to PCa progression through the circSCAF8-miR-140-3p/miR-335-LIF pathway. 1 CircCEMIP promotes anoikis-resistance by enhancing protective autophagy in prostate cancer cells. - hsa_circ_CEMIP CircCEMIP DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated circ_0004585 played an oncogenic role during PCa invasion and metastasis by targeting the miR-1248/TM9SF4 axis . 1 Upregulated circTMEM59 Inhibits Cell Growth and Metastasis by miR-668-3p/ID4 Axis in Colorectal Cancer. - hsa_circ_TMEM59 circTMEM59 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated Upregulated circTMEM59 Inhibits Cell Growth and Metastasis by miR-668-3p/ID4 Axis in Colorectal Cancer. 2 Exosomes Secreted from circZFHX3-modified Mesenchymal Stem Cells Repaired Spinal Cord Injury Through mir-16-5p/IGF-1 in Mice. - hsa_circ_ZFHX3 circZFHX3 DOID:13743 spinal cord lipoma Spinal cord injury RT-qPCR down-regulated "Exosomal circZFHX3 inhibited LPS-induced BV-2 cell injury partly by regulating the miR-16-5p/ IGF-1 axis, hinting at a promising therapeutic strategy for the SCI treatment." 1 Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism. hsa_circ_0004087 - Circ_0004087 DOID:10283 prostate cancer prostate cancer RT-qPCR dysregulated circ_0004087/SND1/MYB/BUB1 axis in modulating the error mitosis correction mechanism and DTX chemoresistance. 1 Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR-135b-3p/TOX3 axis. hsa_circ_0017109 hsa_circ_NID1 circ_0017109 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR dysregulated "melatonin decreases the expression of circ_0017109 and suppresses the non-small-cell lung cancer cell migration, invasion, and proliferation through decreasing TOX3 expression via direct activation of miR-135b-3p." 1 Circ_ARHGAP32 acts as miR-665 sponge to upregulate FGF2 to promote ox-LDL induced vascular smooth muscle cells proliferation and migration. - hsa_circ_ARHGAP32 Circ_ARHGAP32 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Circ_ARHGAP32 might be a potential target for AS treatment, which promoted ox-LDL-induced VSMCs proliferation and migration by regulating miR-665/FGF2 network." 1 Quercetin Inhibits Tumorigenesis of Colorectal Cancer Through Downregulation of hsa_circ_0006990. hsa_circ_0006990 hsa_circ_VAPA circ_0006990 DOID:9256 colorectal cancer colorectal cancer RT-qPCR dysregulated quercetin inhibits the tumorigenesis of CRC via inhibiting the polarisation of M2 macrophages and downregulating hsa_circ_0006990. 3 circRNF20 aggravates the malignancy of retinoblastoma depending on the regulation of miR-132-3p/PAX6 axis. - hsa_circ_RNF20 circRNF20 DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated circRNF20 served as an oncogene in RB progression through the circRNF20/miR-132-3p/PAX6 pathway. 1 CircRNA PVT1 modulated cell migration and invasion through Epithelial-Mesenchymal Transition (EMT) mediation in gastric cancer through miR-423-5p/Smad3 pathway. - hsa_circ_PVT1 circPVT1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "CircPVT1 modulated cell growth, invasion and migration through EMT mediation in gastric cancer through miR-423-5p/Smad3 pathway." 6 Elevated circASCC3 limits antitumor immunity by sponging miR-432-5p to upregulate C5a in non-small cell lung cancer. - hsa_circ_ASCC3 circASCC3 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circASCC3 sponged miR-432-5p to increase complement C5a levels, which enhanced the progression and dysfunctional immune status of NSCLC." 1 Lipopolysaccharide-induced lung cell inflammation and apoptosis are enhanced by circ_0003420/miR-424-5p/TLR4 axis via inactivating the NF-kappaB signaling pathway. hsa_circ_0003420 - circ_0003420 DOID:850 lung disease acute lung injury RT-qPCR up-regulated circ_0003420 contributed to the LPS-induced lung cell injury via activating the miR-424-5p/TLR4-related NF-kappaB signaling pathway. 1 Circ_ZNF652 regulates the proliferation and apoptosis of LPS-induced WI-38 cells via miR-302e/TLR4 axis. - hsa_circ_ZNF652 Circ_ZNF652 DOID:10533 viral pneumonia Infantile pneumonia RT-qPCR up-regulated "Circ_ZNF652 regulates the expression of TLR4 by regulating miR-302e, thereby mediating cell proliferation, apoptosis and inflammation." 3 CircVAPA promotes small cell lung cancer progression by modulating the miR-377-3p and miR-494-3p/IGF1R/AKT axis. - hsa_circ_VAPA CircVAPA DOID:1324 lung cancer lung cancer RT-qPCR up-regulated CircVAPA promotes SCLC progression via the miR-377-3p and miR-494-3p/IGF1R/AKT axis. 1 Circ-GTF2I/miR-590-5p Axis Aggravates Myocardial Ischemia-Reperfusion Injury by Regulating Kelch Repeat and BTB Domain-Containing Protein 7. - rno_circ_GTF2I Circ-GTF2I DOID:1287 cardiovascular system disease myocardial ischemia-reperfusion injury RT-qPCR up-regulated CircRNA circ-GTF2I aggravated MIRI and neonatal rat cardiomyocyte damage in vivo and in vitro by regulating miR-590-5p and the heart development transcription factor KBTBD7. 1 Hsa_circ_0000994 Inhibits Pancreatic Cancer Progression by Clearing Immune-Related miR-27a and miR-27b. hsa_circ_0000994 hsa_circ_SLC8A1 circ_0000994 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR down-regulated Hsa_circ_0000994 inhibited the cancer cells through the effect on miR-27a and miR-27b. 1 Circ-HUWE1 Knockdown Alleviates Amyloid-beta-Induced Neuronal Injury in SK-N-SH Cells via miR-433-3p Release-Mediated FGF7 Downregulation. - hsa_circ_HUWE1 Circ-HUWE1 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR dysregulated circ-HUWE1 knockdown alleviates Amyloid-beta-induced neuronal injury in SK-N-SH cells via miR-433-3p release-mediated FGF7 depletion. 1 CircPCNX Promotes PDGF-BB-Induced Proliferation and Migration of Human Aortic Vascular Smooth Muscle Cells Through Regulating miR-1278/DNMT1 Axis. - hsa_circ_PCNX CircPCNX DOID:178 vascular disease vascular disease RT-qPCR up-regulated CircPCNX promoted PDGF-BB-induced HA-VSMC proliferation and migration by elevating DNMT1 expression through sponging miR-1278. 1 Circ_0006174 promotes the malignancy of colorectal cancer cell via the miR_1205/CCBE1/Wnt pathway. hsa_circ_0006174 - Circ_0006174 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0006174 is an oncogenic circRNA, which participates in the promotion of CRC progression by regulating the miR_1205/CCBE1/Wnt pathway." 5 CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8. - hsa_circ_CERS6 CircCERS6 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "CircCERS6 overexpression hampered the proliferation, migration, invasion, and EMT of EOC cells by up-regulating RASSF8 via sponging miR-630." 1 Circ_0062491 alleviates LPS-induced apoptosis and inflammation in periodontitis by regulating miR-498/SOCS6 axis. hsa_circ_0062491 - Circ_0062491 DOID:824 periodontitis Periodontitis RT-qPCR down-regulated Circ_0062491 protected PDLCs from LPS-induced apoptosis and inflammation. 2 "Circ_0000064 knockdown attenuates high glucose-induced proliferation, inflammation and extracellular matrix deposition of mesangial cells through miR-424-5p-mediated WNT2B inhibition in cell models of diabetic nephropathy." hsa_circ_0000064 - Circ_0000064 DOID:557 kidney disease diabetic nephropathy RT-qPCR down-regulated Circ_0000064 knockdown ameliorated HG-induced HRMC dysfunctions through miR-424-5p enrichment-mediated WNT2B inhibition. 3 Targeting circNCLN/miR-291a-3p/TSLP signaling axis alleviates lipopolysaccharide-induced acute lung injury. - hsa_circ_NCLN circNCLN DOID:850 lung disease acute lung injury RT-qPCR dysregulated circNCLN/miR-291a-3p/TSLP axis may be an important signaling in LPS-induced ALI . 1 EIF4A3-induced circFIP1L1 represses miR-1253 and promotes radiosensitivity of nasopharyngeal carcinoma. - hsa_circ_FIP1L1 circFIP1L1 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR dysregulated "EIF4A3-induced circFIP1L1 repressed NPC cell proliferation, facilitated NPC cell apoptosis, and enhanced NPC radiosensitivity by miR-1253." 2 "CircSRSF4 Enhances Proliferation, Invasion, and Migration to Promote the Progression of Osteosarcoma via Rac1." - hsa_circ_SRSF4 CircSRSF4 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circSRSF4 can be used as an miR-224 sponge to up-regulate the expression of Rac1, thereby promoting the development of osteosarcoma." 1 Bioinformatic analysis of dysregulated circular RNAs in pediatric pulmonary hypertension linked congenital heart disease. - - circ_005372 DOID:1682 congenital heart disease congenital heart disease "RT-qPCR, microarray" up-regulated "circ_003416 expression in the pulmonary arterial hypertension group was significantly downregulated, while circ_005372 expression, in contrast, was significantly upregulated. " 1 Bioinformatic analysis of dysregulated circular RNAs in pediatric pulmonary hypertension linked congenital heart disease. - - circ_003416 DOID:1682 congenital heart disease congenital heart disease "RT-qPCR, microarray" down-regulated "circ_003416 expression in the pulmonary arterial hypertension group was significantly downregulated, while circ_005372 expression, in contrast, was significantly upregulated. " 1 Identification of Novel circRNA-Based ceRNA Network Involved in the Pathogenesis of Gastric Cancer. hsa_circ_0000384 hsa_circ_MRPS35 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated The expression levels of hsa_circ_0000384 and hsa_circ_0000043 were remarkably higher in GC tissues than those in matched adjacent tumor-free gastric tissues. 2 Identification of Novel circRNA-Based ceRNA Network Involved in the Pathogenesis of Gastric Cancer. hsa_circ_0000043 hsa_circ_PUM1 - DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated The expression levels of hsa_circ_0000384 and hsa_circ_0000043 were remarkably higher in GC tissues than those in matched adjacent tumor-free gastric tissues. 1 Circular RNA circNUP214 Modulates the T Helper 17 Cell Response in Patients With Rheumatoid Arthritis. - hsa_circ_NUP214 circNUP214 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR dysregulated circNUP214 functioned as a ceRNA for miR-125a-3p in RA patients. 1 Circ_0081143 Contributes to Gastric Cancer Malignant Development and Doxorubicin Resistance by Elevating the Expression of YES1 by Targeting mziR-129-2-3p. hsa_circ_0081143 - Circ_0081143 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_0081143 knockdown weakened DR resistance and blocked the development of DR-resistant GC by regulating the miR-129-2-3p/YES1 axis. 3 circ-Ncam2 (mmu_circ_0006413) Participates in LPS-Induced Microglia Activation and Neuronal Apoptosis via the TLR4/NF-kappaB Pathway. mmu_circ_0006413 mmu_circ_Ncam2 circ-Ncam2 DOID:13743 spinal cord lipoma Spinal cord injury RT-qPCR up-regulated "Circ-Ncam2 silencing lowered LPS-induced microglia activation and neuronal apoptosis via blocking the TLR4/NF-¦ĘB pathway through acting as a miR-544-3p sponge, suggesting that circ-Ncam2 may be involved in secondary SCI." 1 Hsa_circ_0063804 enhances ovarian cancer cells proliferation and resistance to cisplatin by targeting miR-1276/CLU axis. hsa_circ_0063804 hsa_circ_CELSR1 circ_0063804 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated Circ_0063804 promoted OC cells proliferation and resistance to cisplatin by enhancing CLU expression via sponging miR-1276. 3 Circ_0005925 Promotes Granulosa Cell Growth by Targeting MiR-324-3p to Upregulate MAP2K6 in Polycystic Ovary Syndrome. hsa_circ_0005925 - Circ_0005925 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RT-qPCR up-regulated "circ_0005925 promoted GCs growth through miR-324-3p/MAP2K6, which provided a promising therapeutic target for PCOS." 1 Altered non-coding RNA profiles and potential disease marker identification in peripheral blood mononuclear cells of patients with NMOSD. hsa_circ_0026993 - - DOID:8869 neuromyelitis optica neuromyelitis optica spectrum disorder "RT-qPCR, microarray" dysregulated hsa_circ_0026993 as the potential disease markers for NMOSD. 1 CircRFWD3 promotes HNSCC metastasis by modulating miR-27a/b/PPARgamma signaling. - hsa_circ_RFWD3 CircRFWD3 DOID:5520 head and neck squamous cell carcinoma head and neck squamous cell carcinoma "RT-qPCR, microarray" up-regulated circRFWD3 acts a critical role in promoting the aggressiveness of HNSCC cells and is a prognostic marker for the disease. 1 Circular RNA circ-RCCD promotes cardiomyocyte differentiation in mouse embryo development via recruiting YY1 to the promoter of MyD88. - hsa_circ_RCCD circ-RCCD DOID:1682 congenital heart disease congenital heart disease microarray up-regulated circ-RCCD promoted cardiomyocyte differentiation by recruiting YY1 to the promoter of MyD88. 1 Circ_0006790 carried by bone marrow mesenchymal stem cell-derived exosomes regulates S100A11 DNA methylation through binding to CBX7 in pancreatic ductal adenocarcinoma. hsa_circ_0006790 hsa_circ_MEMO1 Circ_0006790 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" dysregulated MSC-derived exosomal circ_6790 could downregulate S100A11 in PDAC cells and hamper immune escape via CBX7-catalyzed DNA hypermethylation. 1 "hsa_circ_0001741 promotes esophageal squamous cell carcinoma stemness, invasion and migration by sponging miR-491-5p to upregulate NOTCH3 expression." hsa_circ_0001741 hsa_circ_TNPO3 circ_0001741 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "hsa_circ_0001741 promotes ESCC stemness, invasion, and migration by sponging tumor suppressor miR-491-5p to upregulate NOTCH3 expression." 1 Exosomal circRNA_104948 Enhances the Progression of Glioma by Regulating miR-29b-3p and DNMT3B/MTSS1 Signaling. - - circRNA_104948 DOID:0060108 brain glioma glioma RT-qPCR up-regulated circRNA_104948 Enhances the Progression of Glioma by Regulating miR-29b-3p and DNMT3B/MTSS1 Signaling. 1 circRNA circRIMS Downregulates miR-505 through Methylation to Suppress Cell Proliferation in Endometrial Cancer. - hsa_circ_RIMS circRIMS DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated circRIMS may downregulate miR-505 through methylation to increase cell proliferation. 1 "Circ_FURIN promotes trophoblast cell proliferation, migration and invasion in preeclampsia by regulating miR-34a-5p and TFAP2A." - hsa_circ_FURIN Circ_FURIN DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "circ_FURIN enhanced trophoblast cell proliferation, migration and invasion under hypoxic conditions by elevating TFAP2A expression through sponging miR-34a-5p." 2 Hsa_circ_0001550 facilitates colorectal cancer progression through mediating microRNA-4262/nuclear casein kinase and cyclin-dependent kinase substrate 1 cascade. hsa_circ_0001550 hsa_circ_RARS circ_0001550 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Hsa_circ_0001550 facilitated CRC progression by binding to miR-4262 to positively regulate NUCKS1 abundance. 2 Circular RNA Hecw1 Regulates the Inflammatory Imbalance in Spinal Cord Injury via miR-3551-3p/LRRTM1 Axis. - hsa_circ_Hecw1 circHecw1 DOID:319 spinal cord disease spinal cord injury RT-qPCR down-regulated circHecw1 regulates SCI neuronal cell inflammation imbalance by regulating the miR-3551-3p/LRRTM1 signaling. 1 The circular RNA hsa_circ_0003091 regulates sepsis-induced lung injury by sponging the miR-149/Smad2 axis. hsa_circ_0003091 hsa_circ_PFKFB4 - DOID:850 lung disease sepsis-induced acute lung injury "RT-qPCR, RNA-seq" up-regulated hsa_circ_0003091 regulates sepsis-induced lung injury by sponging the miR-149/Smad2 axis. 1 CircSOX9 acts as a molecular sponge of miR-485-3p to promote the progression of nasopharyngeal carcinoma. - hsa_circ_SOX9 CircSOX9 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated circSOX9 acts as an oncogene in the progression of NPC through miR-485-3p/SOX9. 1 Exosomal circRNA FNDC3B promotes the progression of esophageal squamous cell carcinoma by sponging miR-490-5p and regulating thioredoxin reductase 1 expression. - hsa_circ_FNDC3B circFNDC3B DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated exosomal circFNDC3B drove ESCC progression via regulating the miR-490-5p/TXNRD1 axis. 4 The Application of circRNA-016901 in Improving the Diagnostic Accuracy of Osteoarthritis. - - circRNA-016901 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated circRNA-016901 is accumulated to high levels in OA and may be applied to improve the diagnostic accuracy of OA. 1 Circular RNAs Hsa_circ_101555 and Hsa_circ_008068 as Diagnostic Biomarkers for Early-Stage Lung Adenocarcinoma. - - hsa_circ_101555 DOID:3910 lung adenocarcinoma lung adenocarcinoma "RT-qPCR, microarray" up-regulated hsa_circ_101555 and hsa_circ_008068 could serve as novel diagnostic biomarkers for early-stage LUAD. 1 Circular RNAs Hsa_circ_101555 and Hsa_circ_008068 as Diagnostic Biomarkers for Early-Stage Lung Adenocarcinoma. hsa_circ_008068 - hsa_circ_008068 DOID:3910 lung adenocarcinoma lung adenocarcinoma "RT-qPCR, microarray" up-regulated hsa_circ_101555 and hsa_circ_008068 could serve as novel diagnostic biomarkers for early-stage LUAD. 1 Negative regulation of miR-1288-3p/KRT4 axis through a circular RNA in oral cancer. hsa_circ_0096042 - hsa_circ_0096042 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated Hsa_circ_0096042 plays an antitumor role in OSCC via miR-1288-3p/KRT4 axis. 1 circFCHO2 promotes gastric cancer progression by activating the JAK1/STAT3 pathway via sponging miR-194-5p. - hsa_circ_FCHO2 circFCHO2 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circFCHO2 was an oncogene in GC by activating the JAK1/STAT3 pathway via sponging miR-194-5p. 1 CircEXOC5 promotes ferroptosis by enhancing ACSL4 mRNA stability via binding to PTBP1 in sepsis-induced acute lung injury. - mmu_circ_EXOC5 circEXOC5 DOID:850 lung disease acute lung injury RT-qPCR up-regulated "Our study found that the expression of cell ferroptosis and circEXOC5 increased in ALI induced by sepsis, and circEXOC5 aggravated ferroptosis in septic cells by regulating the PTBP1/ACSL4 axis." 1 Down-regulation of circPTTG1IP induces hepatocellular carcinoma development via miR-16-5p/RNF125/JAK1 axis. - hsa_circ_PTTG1IP circPTTG1IP DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated circPTTG1IP is a novel tumor suppresser circRNA in HCC and that a low circPTTG1IP level promotes HCC development via the miR-16-5p/RNF125/JAK1 axis. 1 CircAHNAK upregulates EIF2B5 expression to inhibit the progression of ovarian cancer by modulating the JAK2/STAT3 signaling pathway. - hsa_circ_AHNAK CircAHNAK DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "circAHNAK targets miR-28 to upregulate EIF2B5 expression, thus inhibits progression of ovarian cancer by suppressing JAK2/STAT3 signaling pathway." 1 RUNX3-regulated circRNA METTL3 inhibits colorectal cancer proliferation and metastasis via miR-107/PER3 axis. - hsa_circ_METTL3 circMETTL3 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "CircMETTL3, transcriptionally activated by RUNX3, restrains CRC development and metastasis via acting as a miR-107 sponge to regulate PER3 signaling." 4 MALAT1-dependent hsa_circ_0076611 regulates translation rate in triple-negative breast cancer. hsa_circ_0076611 hsa_circ_VEGFA circ_0076611 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR dysregulated circ_0076611 favors the expression of its target mRNAs by facilitating their interaction with components of the translation initiation machinery. 1 Hsa_circ_0046523 Mediates an Immunosuppressive Tumor Microenvironment by Regulating MiR-148a-3p/PD-L1 Axis in Pancreatic Cancer. hsa_circ_0046523 hsa_circ_TBCD circ_0046523 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated sa_circ_0046523/miR-148a-3p/PD-L1 regulatory axis mediates PC immunosuppressive microenvironment and these molecules are expected to be new targets for remodeling tumor immune microenvironment of PC. 1 circDNMT1 Promotes Malignant Progression of Gastric Cancer Through Targeting miR-576-3p/Hypoxia Inducible Factor-1 Alpha Axis. - hsa_circ_DNMT1 circDNMT1 DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated "circDNMT1 knockdown inhibited GC proliferation, migration, invasion and glycolysis through sponging miR-576-3p/HIF-1alpha axis. " 1 Circle RNA circCSPP1 promotes human osteosarcoma cell proliferation and increases glucose metabolism by suppressing miR-200c maturation. - hsa_circ_CSPP1 circCSPP1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated CircCSPP1 promotes OS cell proliferation and increases glucose metabolism by suppressing miR-200c maturation. 1 CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR-30a-3p and promoting PON2. - hsa_circ_HIPK3 CircHIPK3 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "circHIPK3 regulated chondrocyte apoptosis by mitochondrial pathway, and targeting the circHIPK3/miR-30a-3p/PON2 axis." 2 Circ_0060551 promotes the migration and invasion of cervical cancer by upregulating TPD52. hsa_circ_0060551 - Circ_0060551 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circ_0060551 could promote the migration and invasion of cervical cancer cells. 1 "Hsa_circ_0006427 Suppresses Multiplication, Migration and Invasion of Non-Small Cell Lung Cancer Cells through miR-346/VGLL4 Pathway." hsa_circ_0006427 hsa_circ_BCAR3 circ_0006427 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated Circ_0006427/miR-346/VGLL4 axis regulated NSCLC progression. 2 Circular RNA FUNDC1 for Prediction of Acute Phase Outcome and Long-Term Survival of Acute Ischemic Stroke. - hsa_circ_FUNDC1 circFUNDC1) DOID:2316 brain ischemia acute ischemic stroke RT-qPCR up-regulated Circulating circFUNDC1 could be a potential biomarker for predicting acute-phase outcome and long-term survival in AIS. 2 DNA Methylation-Related circRNA_0116449 Is Involved in Lipid Peroxidation in Traumatic Brain Injury. hsa_circ_0116449 - circRNA_0116449 DOID:81292 traumatic brain injury traumatic brain injury microarray dysregulated DNA methylation-related circ_0116449 may be a novel target for regulating lipid metabolism in TBI. 1 Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer. - hsa_circ_ELP3 circ-ELP3 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated Circ-ELP3 and its host gene were significantly upregulated in TNBC. 1 Cyanidin-3-Glucoside Modulates hsa_circ_0001345/miRNA106b/ATG16L1 Axis Expression as a Potential Protective Mechanism against Hepatocellular Carcinoma. hsa_circ_0001345 hsa_circ_TRPC1 circ_0001345 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Cyanidin-3-Glucoside Modulates hsa_circ_0001345/miRNA106b/ATG16L1 Axis Expression as a Potential Protective Mechanism against Hepatocellular Carcinoma. 1 CircCDK14 ameliorates interleukin-1beta-induced chondrocyte damage by the miR-1183/KLF5 pathway in osteoarthritis. - hsa_circ_CDK14 CircCDK14 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated CircCDK14 reintroduction assuaged IL-1beta-caused chondrocyte damage by the miR-1183/KLF5 pathway. 1 "Silencing CircEIF3I/miR-526b-5p Axis Epigenetically Targets HGF/c-Met Signal to Hinder the Malignant Growth, Metastasis and Angiogenesis of Hepatocellular Carcinoma." - hsa_circ_EIF3I CircEIF3I DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircEIF3I was an oncogenic circRNA in HCC-, and interfering circEIF3I exhibited anti-HCC activity via circEIF3I-miR-526b-5p-HGF/c-Met pathway." 2 Mesenchymal stem cells-derived exosomes prevent sepsis-induced myocardial injury by a CircRTN4/miR-497-5p/MG53 pathway. - hsa_circ_RTN4 CircRTN4 DOID:0040085 bacterial sepsis sepsis RT-qPCR down-regulated MSCs-derived exosomes prevent sepsis-induced myocardial injury by a circRTN4/miR-497-5p/MG53 pathway. 1 Profiling and integrated analysis of differentially expressed circRNAs in cervical cancer. hsa_circ_0026377 hsa_circ_KRT81 - DOID:4362 cervical cancer cervical cancer RNA-seq down-regulated hsa_circ_0026377 might play important roles in CCa development. 1 Circular RNA EPB41 expression predicts unfavorable prognoses in NSCLC by regulating miR-486-3p/eIF5A axis-mediated stemness. - hsa_circ_EPB41 circ-EPB41 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RNA-seq up-regulated circ-EPB41 in regulating NSCLC cell invasion and proliferation by modifying miR-486-3p/eIF5A axis-mediated stemness. 1 Circular RNA hsa_circ_0004381 Promotes Neuronal Injury in Parkinson Disease Cell Model by miR-185-5p/RAC1 Axis. hsa_circ_0004381 hsa_circ_ARID1B - DOID:14330 Parkinson disease Parkinson disease RT-qPCR up-regulated Hsa_circ_0004381 could contribute to MPP(+)-triggered neuron injury by targeting the miR-185-5p/RAC1 axis. 1 Exosomal Circular RNA hsa_circ_0046060 of Umbilical Cord Mesenchymal Stromal Cell Ameliorates Glucose Metabolism and Insulin Resistance in Gestational Diabetes Mellitus via the miR-338-3p/G6PC2 Axis. hsa_circ_0046060 hsa_circ_RPTOR - DOID:11714 gestational diabetes gestational diabetes mellitus RT-qPCR dysregulated hsa_circ_0046060 expression in exosomes from GDM-derived UMSCs can alleviate GDM by reversing abnormal glucose metabolism and insulin resistance in vivo and in vitro. 1 circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis. hsa_circ_0003204 - circ_0003204 DOID:0080001 bone disease osteogenic differentiation RT-qPCR down-regulated circ_0003204 increased the bone formation and promoted the expression of osteogenic-related proteins. 1 "Circ_0060077 Knockdown Alleviates High-Glucose-Induced Cell Apoptosis, Oxidative Stress, Inflammation and Fibrosis in HK-2 Cells via miR-145-5p/VASN Pathway." hsa_circ_0060077 - circ_0060077 DOID:9743 diabetic neuropathy diabetic nephropathy RT-qPCR up-regulated Circ_0060077 silencing protected HK-2 cells from HG-induced damage by regulating miR-145-5p/VASN axis. 1 Circular RNA hsa_circ_0000437 may be used as a new indicator for the diagnosis and prognosis of hepatocellular carcinoma. hsa_circ_0000437 hsa_circ_CORO1C - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated circ_0000437 may be used as a novel biomarker for the diagnosis and prognosis of patients with HCC. 3 Silencing of circular RNA_ZYG11B exerts a neuroprotective effect against retinal neurodegeneration. hsa_circ_0003739 hsa_circ_ZYG11B circZYG11B DOID:5679 retinal disease Ischemic retinal diseases RT-qPCR up-regulated circZYG11B expression was markedly increased in the aqueous humor of patients with glaucoma. 1 Circ_0000705 facilitates proline metabolism of esophageal squamous cell carcinoma cells by targeting miR-621/PYCR1 axis. hsa_circ_0000705 - Circ_0000705 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated circ_0000705 promoted proline metabolism and malignant progression of ESCC by regulating the miR_621/PYCR1 axis. 1 Hsa_circ_0000437 Inhibits the Development of Endometrial Carcinoma through miR-626/CDKN1B Axis. hsa_circ_0000437 hsa_circ_CORO1C circ_0000437 DOID:1380 endometrial cancer endometrial cancer RT-qPCR down-regulated "Circ_0000437 regulates the miR-626/CDKN1B pathway to suppress the proliferation, invasion and EMT of EC cells." 2 Circ_0051079 silencing inhibits the malignant phenotypes of osteosarcoma cells by the TRIM66/Wnt/beta-catenin pathway in a miR-625-5p-dependent manner. hsa_circ_0051079 - Circ_0051079 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ_0051079 regulated OS development by the miR-625-5p/TRIM66/Wnt/beta-catenin pathway, providing a novel therapeutic target for OS." 3 Circ_0004951 Promotes Pyroptosis of Renal Tubular Cells via the NLRP3 Inflammasome in Diabetic Kidney Disease. hsa_circ_0004951 - Circ_0004951 DOID:557 kidney disease diabetic kidney disease RT-qPCR up-regulated "Circ_0004951 promotes pyroptosis of renal tubular epithelial cells in DKD via the miR-93-5p/NLRP3 inflammasome pathway, suggesting its potential for clinical diagnosis and treatment of DKD." 1 The Particular Expression Profiles of Circular RNA in Peripheral Blood of Myocardial Infarction Patients by RNA Sequencing. - hsa_circ_TMEM165 circTMEM165 DOID:5844 myocardial infarction myocardial Infarction RNA-seq dysregulated "circTMEM165, circUBAC2, circZNF609, circANKRD12, and circSLC8A1 were reconfirmed by RT-qPCR in the cell model." 1 The Particular Expression Profiles of Circular RNA in Peripheral Blood of Myocardial Infarction Patients by RNA Sequencing. - - cirbac2 DOID:5844 myocardial infarction myocardial Infarction RNA-seq dysregulated "circTMEM165, circUBAC2, circZNF609, circANKRD12, and circSLC8A1 were reconfirmed by RT-qPCR in the cell model." 1 The Particular Expression Profiles of Circular RNA in Peripheral Blood of Myocardial Infarction Patients by RNA Sequencing. - hsa_circ_ZNF609 circZNF609 DOID:5844 myocardial infarction myocardial Infarction RNA-seq dysregulated "circTMEM165, circUBAC2, circZNF609, circANKRD12, and circSLC8A1 were reconfirmed by RT-qPCR in the cell model." 1 The Particular Expression Profiles of Circular RNA in Peripheral Blood of Myocardial Infarction Patients by RNA Sequencing. - hsa_circ_ANKRD12 circANKRD12 DOID:5844 myocardial infarction myocardial Infarction RNA-seq dysregulated "circTMEM165, circUBAC2, circZNF609, circANKRD12, and circSLC8A1 were reconfirmed by RT-qPCR in the cell model." 1 The Particular Expression Profiles of Circular RNA in Peripheral Blood of Myocardial Infarction Patients by RNA Sequencing. - hsa_circ_SLC8A circSLC8A DOID:5844 myocardial infarction myocardial Infarction RNA-seq dysregulated "circTMEM165, circUBAC2, circZNF609, circANKRD12, and circSLC8A1 were reconfirmed by RT-qPCR in the cell model." 1 "circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop." - hsa_circ_EXOC6B circEXOC6B DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated circEXOC6B inhibits the progression of CRC and enhances the chemosensitivity of CRC cells to 5-fluorouracil by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop. 1 Sus_circPAPPA2 Regulates Fat Deposition in Castrated Pigs through the miR-2366/GK Pathway. - ssc_circ_PAPPA2 sus_circPAPPA2 DOID:9452 fatty liver disease fat "RT-qPCR, RNA-seq" up-regulated This study provides basic data enhancing the understanding of the interaction between the hormone environment and mir-2366/GK to regulate trait performance in pigs. 1 CircXPO5 Plays a Neuroprotective Function in the Lateral Geniculate Nucleus of Glaucoma by Regulating GRIN2A. - hsa_circ_XPO5 CircXPO5 DOID:1686 glaucoma glaucoma "RT-qPCR, RNA-seq" down-regulated the reduction in circXPO5 may have a protective effect on neuronal apoptosis in the visual central system of glaucoma. 1 CircDCLRE1C Regulated Lipopolysaccharide-Induced Inflammatory Response and Apoptosis by Regulating miR-214b-3p/STAT3 Pathway in Macrophages. gga_circ_0001674 gga_circ_DCLRE1C CircDCLRE1C DOID:0050117 disease by infectious agent The immune cell inflammation response RT-qPCR up-regulated "circDCLRE1C could aggravate LPS-induced inflammation and apoptosis through competitive adsorption of miR-214b-3p, thereby increasing the expression of STAT3." 1 circ-RANGAP1/MicroRNA-542-3p/Myosin Regulatory Light Chain Interacting Protein Axis Modulates the Osteosarcoma Cell Progression. - hsa_circ_RANGAP1 circ-RANGAP1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Silenced circ-RANGAP1 boosts MYLIP expression via competitive binding of miR-542-3p to facilitate OS cell progression. 1 "Serum and Serum Exosomal CircRNAs hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 as Diagnostic Biomarkers for Lung Adenocarcinoma." hsa_circ_0001492 hsa_circ_ERBB2IP - DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated "The serum and serum exosomal circRNAs, hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896, were upregulated in LUAD patients." 1 "Serum and Serum Exosomal CircRNAs hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 as Diagnostic Biomarkers for Lung Adenocarcinoma." hsa_circ_0001439 hsa_circ_SCLT1 - DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated "The serum and serum exosomal circRNAs, hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896, were upregulated in LUAD patients." 1 "Serum and Serum Exosomal CircRNAs hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 as Diagnostic Biomarkers for Lung Adenocarcinoma." hsa_circ_0000896 hsa_circ_FARSA - DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated "The serum and serum exosomal circRNAs, hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896, were upregulated in LUAD patients." 1 Sevoflurane suppresses hepatocellular carcinoma cell progression via circ_0001649/miR-19a-3p/SGTB axis. hsa_circ_0001649 - circ_0001649 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR dysregulated sevoflurane inhibited HCC cell development via circ_0001649/miR-19a-3p/SGTB axis. 4 Circ_0017274 acts on miR-637/CDX2 axis to facilitate cisplatin resistance in gastric cancer. hsa_circ_0017274 - Circ_0017274 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_0017274 downregulation boosted CDDP sensitivity by acting on miR-637/CDX2 in CDDP-resistant GC cells. 1 CircDLG1 promotes malignant development of non-small cell lung cancer through regulation of the miR-630/CENPF axis. - hsa_circ_DLG1 CircDLG1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircDLG1 knockdown could impede NSCLC advancement through modulating the miR-630/CENPF axis. 2 "Circ-HSP90A expedites cell growth, stemness, and immune evasion in non-small cell lung cancer by regulating STAT3 signaling and PD-1/PD-L1 checkpoint." - hsa_circ_HSP90A Circ-HSP90A DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR dysregulated "circ-HSP90A promoted cell growth, stemness, and immune evasion in NSCLC through regulating STAT3 signaling and programmed cell death 1 (PD-1)/PD-L1 checkpoint." 1 Circular RNA hsa_circ_0043688 serves as a competing endogenous RNA for microRNA-145-5p to promote the progression of Keloids via Fibroblast growth factor-2. hsa_circ_0043688 hsa_circ_FKBP10 - DOID:10881 "hand, foot and mouth disease" keloids RT-qPCR up-regulated Hsa_circ_0043688 knockdown inhibited cell growth and metastasis of keloid fibroblasts via miR-145-5p/FGF2. 2 Plasma Exosomal hsa_circ_0015286 as a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer. hsa_circ_0015286 hsa_circ_GAS5 circ_0015286 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated exosomal hsa_circ_0015286 might be a promising noninvasive biomarker for the diagnosis and prognosis evaluation of GC. 1 Targeted Analysis of circRNA Expression in Patient Samples by Lexo-circSeq. - hsa_circ_SLC8A1 circSLC8A1 DOID:0050700 cardiomyopathy cardiomyopathy RNA-seq down-regulated circSLC8A1 and circRBM33 are deregulated in cardiomyopathy. 1 Targeted Analysis of circRNA Expression in Patient Samples by Lexo-circSeq. - hsa_circ_RBM33 circRBM33 DOID:0050700 cardiomyopathy cardiomyopathy RNA-seq down-regulated circSLC8A1 and circRBM33 are deregulated in cardiomyopathy. 1 Circular RNA circ-ABCB10 Promotes Proliferation and Inhibits Apoptosis of Laryngeal Carcinoma by Inhibiting KLF6. - hsa_circ_ABCB10 circ-ABCB10 DOID:2600 laryngeal carcinoma laryngeal cancer RT-qPCR down-regulated "Silencing circ-ABCB10 could significantly inhibit the growth and proliferation of laryngeal adenocarcinoma cells, while overexpression of circ-ABCB10 could significantly promote the growth of laryngeal adenocarcinoma cells, probably by inhibiting KLF6 to enhance the proliferation of laryngeal carcinoma and inhibit apoptosis." 1 Mechanism of Liver Regeneration During ALPPS. - - circ-0067724 DOID:409 liver disease associating liver partition and portal vein ligation for staged hepatectomy RT-qPCR up-regulated loss of circ-0067724 and circ-0016213 could suppress liver cell proliferation. 1 Mechanism of Liver Regeneration During ALPPS. - - circ-0016213 DOID:409 liver disease associating liver partition and portal vein ligation for staged hepatectomy RT-qPCR up-regulated loss of circ-0067724 and circ-0016213 could suppress liver cell proliferation. 1 A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity. - hsa_circ_INSR Circ-INSR DOID:114 heart disease heart failure RNA-seq down-regulated Circ-INSR is a highly conserved non-coding RNA which is down-regulated during cardiotoxicity and cardiac remodelling. 1 "Circular RNA_0078767 upregulates Kruppel-like factor 9 expression by targeting microRNA-889, thereby inhibiting the progression of osteosarcoma." hsa_circ_0078767 - Circ_0078767 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" down-regulated circ_0078767 enhances KLF9 expression by targeting miR-889 to inhibit OS progression. 3 Circ_0000395 Promoted CRC Progression via Elevating MYH9 Expression by Sequestering miR-432-5p. hsa_circ_0000395 hsa_circ_SLC38A1 Circ_0000395 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circ_0000395 sequestered miR-432-5p to elevate MYH9 expression, resulting in facilitating CRC progression." 1 Circ_0000523 regulates miR-1184/COL1A1/PI3K/Akt pathway to promote nasopharyngeal carcinoma progression. hsa_circ_0000523 - Circ_0000523 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated Circ_0000523 facilitates NPC progression through regulating the miR-1184/COL1A1 axis. 1 Circular RNA UBAP2 (hsa_circ_0007367) Correlates with Microcirculatory Perfusion and Predicts Outcomes of Cardiogenic Shock Patients Undergoing Extracorporeal Membrane Oxygenation Support. hsa_circ_0007367 hsa_circ_UBAP2 circUBAP2 DOID:114 heart disease cardiogenic shock RT-qPCR dysregulated "circUBAP2 inhibited the migratory activity and promoted M2 polarization in macrophages, declining the productions of cytokines (tumor necrosis factor [TNF]-alpha, interleukin [IL]-1beta, and monocyte chemotactic protein [MCP]-1) and the PI3K/Akt/mTOR pathway." 2 CircRNA circ_0006156 inhibits the metastasis of prostate cancer by blocking the ubiquitination of S100A9. hsa_circ_0006156 - circ_0006156 DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" down-regulated circ_0006156 suppresses PCa migration and invasion by increasing S100A9. 1 Propofol Suppresses Glioma Tumorigenesis by Regulating circ_0047688/miR-516b-5p/IFI30 Axis. hsa_circ_0047688 - circ_0047688 DOID:0060108 brain glioma glioma RT-qPCR up-regulated Propofol inhibited glioma progression via modulating circ_0047688/miR-516b-5p/IFI30 axis. 1 Circ_0062582 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells in vitro by elevating SMAD5 expression through sponging miR-197-3p. hsa_circ_0062582 - Circ_0062582 DOID:11476 osteoporosis osteoporosis RT-qPCR down-regulated "circ_0062582 sponged miR-197-3p to elevate SMAD5 expression, thereby inducing hBMSC proliferation and osteogenic differentiation in vitro." 1 Hsa_circ_0005100 regulates tumorigenicity of colorectal carcinoma via miR-145-5p/MACC1 axis. hsa_circ_0005100 hsa_circ_FMN2 circ_0005100 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Hsa_circ_0005100 was a vital regulator in the development of CRC by miR-145-5p/MACC1 axis. 4 Circ_TLK1 knockdown alleviates oxygen-glucose deprivation/reoxygenation-induced PC12 cell injury by regulating microRNA-136-5p/follistatin like-1 axis. - hsa_circ_TLK1 Circ_TLK1 DOID:6713 cerebrovascular disease ischemic stroke RT-qPCR up-regulated Circ_TLK1 knockdown ameliorated OGD/R-induced PC12 cell injury by modulating miR-136-5p and FSTL1. 3 CircRNA-3302 promotes endothelial-to-mesenchymal transition via sponging miR-135b-5p to enhance KIT expression in Kawasaki disease. - - CircRNA-3302 DOID:13378 Kawasaki disease Kawasaki disease RNA-seq up-regulated circRNA-3302 plays an important role in KD-associated EndMT. 1 circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer. - hsa_circ_FBXO7 circFBXO7 DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, RNA-seq" down-regulated circFBXO7 acts as a bone fide tumor suppressor in ovarian cancer and that the circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt/beta-catenin signaling pathway . 1 circACTG1 Promotes Hepatocellular Carcinoma Progression by Regulating miR-940/RIF1 Axis and Activating AKT/mTOR Pathway. hsa_circ_0046144 hsa_circ_ACTG1 circACTG1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circACTG1 potentially regulates HCC cell proliferation, invasion, and migration via miR-940/RIF1/AKT/mTOR pathway." 1 Novel circularRNA circ-0047078 promotes pancreatic ductal adenocarcinoma progression through mircoRNA miR-11181- Chemokine (C-X-C motif) Ligand 12/Melanoma Cell Adhesion Molecule/Regulator of G-protein signaling 16 pathway. hsa_circ_0047078 - circ-0047078 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" up-regulated "circ-0047078 plays a role in promoting PDAC via miR-11181 and then via CXCL12, MCAM and RGS16." 1 Silencing of Circ_0135889 Restrains Proliferation and Tumorigenicity of Human Neuroblastoma Cells. hsa_circ_0135889 - Circ_0135889 DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated Circ_0135889 promoted the tumorigenicity of NB by regulating miR-127-5p/NEUROD1 axis. 2 Hsa_circ_0010729 regulates H(2)O(2)-induced myocardial injury by regulating miR-1184/RIPK1 axis. hsa_circ_0010729 hsa_circ_HSPG2 circ_0010729 DOID:936 brain disease Ischemia-reperfusion RT-qPCR up-regulated Circ_0010729 promotes H(2)O(2)-induced myocardial injury. 1 CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA. hsa_circ_0006357 hsa_circ_EZH2 CircEZH2 DOID:9256 colorectal cancer colorectal cancer RNA-seq up-regulated "circEZH2 in modulating CRC progression, but also advocate for attenuating circEZH2/miR-133b/IGF2BP2/ CREB1 regulatory axis to combat CRC." 1 Circ_0061395 functions as an oncogenic gene in hepatocellular carcinoma by acting as a miR-1182 sponge. hsa_circ_0061395 - Circ_0061395 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ_0061395 induced the changes of the expression of SPOCK1 by regulating miR-1182. 4 circ-CCND1 regulates the CCND1/P53/P21 pathway through sponging miR-138-5p in valve interstitial cells to aggravate aortic valve calcification. - hsa_circ_CCND1 circ-CCND1 DOID:114 heart disease calcified aortic valve disease "RT-qPCR, microarray" up-regulated Circ-CCND1 sponges miR-138-5p to regulate CCND1 expression. 1 Circular RNA VPS18 Promotes Glioblastoma Progression by Regulating miR-1229-3p/BCAT1 Axis. - hsa_circ_VPS18 CircVPS18 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated CircVPS18 accelerated glioblastoma progression by miR-1229-3p/BCAT1 axis. 2 CircPDHX promotes prostate cancer cell progression in vitro and tumor growth in vivo via miR-497-5p/ACSL1 axis. - hsa_circ_PDHX CircPDHX DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "CircPDHX stimulated PCa development via miR-497-5p/ACSL1, which presented a new thought for PCa treatment." 2 Circular RNA circSEPT9 Is Upregulated in Endometrial Cancer and Promotes Cell Invasion and Migration by Downregulating miR-186 through Methylation. - hsa_circ_SEPT9 circSEPT9 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated circSEPT9 is upregulated in EC and promotes cell invasion and migration by downregulating miR-186 through methylation. 1 hsa_circ_0115355 promotes pancreatic beta-cell function in patients with type 2 diabetes through the miR-145/SIRT1 axis. hsa_circ_0115355 - circ_0115355 DOID:9352 type 2 diabetes mellitus type 2 diabetes RT-qPCR down-regulated hsa_circ_0115355 inhibits the occurrence and development of T2DM by regulating the expression of SIRT1 by adsorbing miR-145. 1 circEPSTI1 promotes tumor progression and cisplatin resistance via upregulating MSH2 in cervical cancer. - hsa_circ_EPSTI1 circEPSTI1 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circEPSTI1 promotes tumor progression and cisplatin resistance via upregulating MSH2 in cervical cancer. 2 Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of beta-catenin by promoting delta-catenin ubiquitin degradation and upregulating SIK1. hsa_circ_0007991 hsa_circ_EIF4G3 circEIF4G3 DOID:10534 stomach cancer gastric cancer microarray up-regulated Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of beta-catenin by promoting delta-catenin ubiquitin degradation and upregulating SIK1. 4 The potential of CircRNA1002 as a biomarker in hepatitis B virus-related hepatocellular carcinoma. - - CircRNA1002 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated circRNA1002 may be a reliable serum biomarker for HCC. 1 Identification of circular RNA_0000919 as a potential diagnostic and prognostic biomarker of tongue squamous cell carcinoma using circular RNA microarray and reverse transcription-quantitative PCR analyses. hsa_circ_0000919 - circ_0000919 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma "RT-qPCR, microarray" up-regulated circ_0000919 as a diagnostic and prognostic biomarker for TSCC management. 1 "circIFT80 Functions as a ceRNA for miR-142, miR-568, and miR-634 and Promotes the Progression of Colorectal Cancer by Targeting beta-Catenin." - hsa_circ_IFT80 circIFT80 DOID:9256 colorectal cancer colorectal cancer microarray up-regulated "circIFT80 as ceRNA in the progression of CRC, by which sponging miR-142, miR-568, and miR-634 enhanced the expression levels of beta-catenin and activation Wnt/beta-catenin pathway." 3 circCCT3 Enhances Invasion and Epithelial-Mesenchymal Transition (EMT) of Non-Small-Cell Lung Cancer (NSCLC) via the miR-107/Wnt/FGF7 Axis. - hsa_circ_CCT3 circCCT3 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circCCT3/miR-107/Wnt/FGF7 responsible for NSCLC metastasis. 1 "Circ_0138959/miR-495-3p/TRAF6 axis regulates proliferation, wound healing and osteoblastic differentiation of periodontal ligament cells in periodontitis." hsa_circ_0138959 - Circ_0138959 DOID:824 periodontitis Periodontitis RT-qPCR up-regulated "circ_0138959 upregulated the TRAF6 expression by binding to miR-495-3p, consequently aggravating LPS-induced cell damages in PDLCs." 1 Huaier Induces Immunogenic Cell Death Via CircCLASP1/PKR/eIF2alpha Signaling Pathway in Triple Negative Breast Cancer. - hsa_circ_CLASP1 CircCLASP1 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, RNA-seq" dysregulated Huaier Induces Immunogenic Cell Death Via CircCLASP1/PKR/eIF2alpha Signaling Pathway in Triple Negative Breast Cancer. 1 Construction of a Novel circRNA/miRNA/mRNA Regulatory Network to Explore the Potential Pathogenesis of Wilson Disease. mmu_circ_0001333 - mmu_circ_0001333 DOID:557 kidney disease WD-related kidney injury RNA-seq down-regulated "mmu_circ_0001333 and mmu_circ_0000355 acted as sponges of miR-92b-5p, miR-107-3p, and miR-187-3p to regulate the expression of genes including Smad9, Mapk10, and Aldh3a2, which may participate in WD-related kidney injury." 2 Construction of a Novel circRNA/miRNA/mRNA Regulatory Network to Explore the Potential Pathogenesis of Wilson Disease. mmu_circ_0001333 - mmu_circ_0001333 DOID:557 kidney disease WD-related kidney injury RNA-seq dysregulated "mmu_circ_0001333 and mmu_circ_0000355 acted as sponges of miR-92b-5p, miR-107-3p, and miR-187-3p to regulate the expression of genes including Smad9, Mapk10, and Aldh3a2, which may participate in WD-related kidney injury." 2 Downregulation of hsa_circ_0000885 suppressed osteosarcoma metastasis and progression via regulating E2F3 expression and sponging miR-16-5p. hsa_circ_0000885 hsa_circ_INSR circ_0000885 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated hsa_circ_0000885 downregulation suppressed OS progression and metastasis via regulating E2F3 expression and sponging miR-16-5p. 2 Analysis of circRNAs profile in TNF-alpha treated DPSC. hsa_circ_0001978 hsa_circ_TCONS_l2_00001804 - DOID:11121 pulpitis Pulpitis RNA-seq up-regulated hsa_circ_0001978 and hsa_circ_0004417 were increased in patients suffering from pulpitis. 1 Analysis of circRNAs profile in TNF-alpha treated DPSC. hsa_circ_0004417 - - DOID:11121 pulpitis Pulpitis RNA-seq up-regulated hsa_circ_0001978 and hsa_circ_0004417 were increased in patients suffering from pulpitis. 1 A novel circ_0000654/miR-375/E2F3 ceRNA network in esophageal squamous cell carcinoma. hsa_circ_0000654 - circ_0000654 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated circ_0000654/miR-375/E2F3 ceRNA crosstalk for the oncogenic role of circ_0000654 in ESCC . 2 "CircRNA, lncRNA, and mRNA profiles of umbilical cord blood exosomes from preterm newborns showing bronchopulmonary dysplasia." hsa_circ_0086913 hsa_circ_TLN1 - DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, microarray" up-regulated The expression levels of circRNAs hsa_circ_0049170 and hsa_circ_0087059 were upregulated in LPS-induced BEAS-2B cells; the expression level of hsa_circ_0086913 was upregulated and that of hsa_circ_0065188 was downregulated in LPS-induced HUVECs. 1 "CircRNA, lncRNA, and mRNA profiles of umbilical cord blood exosomes from preterm newborns showing bronchopulmonary dysplasia." hsa_circ_0049170 hsa_circ_OLFM2 - DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, microarray" up-regulated The expression levels of circRNAs hsa_circ_0049170 and hsa_circ_0087059 were upregulated in LPS-induced BEAS-2B cells; the expression level of hsa_circ_0086913 was upregulated and that of hsa_circ_0065188 was downregulated in LPS-induced HUVECs. 1 "CircRNA, lncRNA, and mRNA profiles of umbilical cord blood exosomes from preterm newborns showing bronchopulmonary dysplasia." hsa_circ_0087059 hsa_circ_GRHPR - DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, microarray" up-regulated The expression levels of circRNAs hsa_circ_0049170 and hsa_circ_0087059 were upregulated in LPS-induced BEAS-2B cells; the expression level of hsa_circ_0086913 was upregulated and that of hsa_circ_0065188 was downregulated in LPS-induced HUVECs. 1 "CircRNA, lncRNA, and mRNA profiles of umbilical cord blood exosomes from preterm newborns showing bronchopulmonary dysplasia." hsa_circ_0065188 hsa_circ_PTPN23 - DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, microarray" down-regulated The expression levels of circRNAs hsa_circ_0049170 and hsa_circ_0087059 were upregulated in LPS-induced BEAS-2B cells; the expression level of hsa_circ_0086913 was upregulated and that of hsa_circ_0065188 was downregulated in LPS-induced HUVECs. 1 CircCOL1A2 Sponges MiR-1286 to Promote Cell Invasion and Migration of Gastric Cancer by Elevating Expression of USP10 to Downregulate RFC2 Ubiquitination Level. - hsa_circ_COL1A2 CircCOL1A2 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated CircCOL1A2 sponges miR-1286 to promote cell invasion and migration of GC by elevating the expression of USP10 to downregulate the level of RFC2 ubiquitination. 2 CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis. - hsa_circ_NFIX CircNFIX DOID:8398 osteoarthritis osteoarthritis microarray down-regulated CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis. 1 Overexpression of circ PTK2 suppresses the progression of nonalcoholic fatty liver disease via the miR-200c/SIK2/PI3K/Akt axis. - mmu_circ_PTK2 circ PTK2 DOID:80208 non-alcoholic fatty liver disease non-alcoholic fatty liver disease RT-qPCR down-regulated Circ PTK2 overexpression alleviates NAFLD development via the miR-200c/SIK2/PI3K/Akt axis. 1 Prognostic significance of hsa_circ_0048122 to predict liver metastasis in early-stage colorectal cancer. hsa_circ_0048122 hsa_circ_C19orf6 circ_0048122 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Hsa_circ_0048122 as a biomarker in early-stage CRC cases. 1 Circular RNA circ_0079593 facilitates glioma development via modulating miR-324-5p/XBP1 axis. hsa_circ_0079593 - circ_0079593 DOID:0060108 brain glioma glioma RT-qPCR up-regulated Circ_0079593 triggered glioma development via miR-324-5p/XBP1 axis. 3 The tumor suppressor function of hsa_circ_0006282 in gastric cancer through PTEN/AKT pathway. hsa_circ_0006282 hsa_circ_TCEB1 circ_0006282 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "By regulating the PTEN/AKT signaling pathway through competitively binding with hsa-miR-136-5p, hsa_circ_0006282 suppresses the growth of gastric cancer." 3 Circular RNA hsa_circ_0012673 Promotes Breast Cancer Progression via miR-576-3p/SOX4 Axis. hsa_circ_0012673 hsa_circ_DHCR24 - DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "hsa_circ_0012673 sponged miR-576-3p to stabilize SRY-box transcription factor 4 (SOX4), and thereby facilitating breast cancer cell proliferation, migration and invasion." 1 CircASPH Promotes Hepatocellular Carcinoma Progression Through Methylation and Expression of HAO2. - hsa_circ_ASPH CircASPH DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circASPH could regulate the methylation of the promoter and expression of hydrocyanic oxidase 2 (HAO2) to promote HCC progression by acting as a sponge for miR-370-3p, and miR-370-3p could target DNMT3b and increase the 5mC level." 2 Exosomal hsa_circ_0017252 attenuates the development of gastric cancer via inhibiting macrophage M2 polarization. hsa_circ_0017252 hsa_circ_AKT3 circ_0017252 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated exosomal hsa_circ_0017252 excreted from GC cells attenuated GC progression by suppressing macrophage M2-like polarization. 4 CircME1 promotes aerobic glycolysis and sunitinib resistance of clear cell renal cell carcinoma through cis-regulation of ME1. - hsa_circ_ME1 CircME1 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, RNA-seq" dysregulated "circME1 interacted with U1 snRNP at the promoter of its parental gene ME1, thereby upregulating the expression of ME1, enhancing aerobic glycolysis of ccRCC, and promoting its malignant phenotype." 1 "Circ-FOXM1 promotes the proliferation, migration and EMT process of osteosarcoma cells through FOXM1-mediated Wnt pathway activation." - hsa_circ_FOXM1 Circ-FOXM1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circ-FOXM1 facilitated the malignant phenotypes of OS cells through FOXM1-mediated Wnt pathway activation. 1 Circular RNA drives resistance to anti-PD-1 immunotherapy by regulating the miR-30a-5p/SOX4 axis in non-small cell lung cancer. hsa_circ_0020714 hsa_circ_CD151 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Hsa_circ_0020714 induces the immune evasion and resistance to anti-PD-1 immunotherapy of NSCLC via the miR-30a-5p/SOX4 axis. 1 CircRTN1 acts as a miR-431-5p sponge to promote thyroid cancer progression by upregulating TGFA. - hsa_circ_RTN1 CircRTN1 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated CircRTN1 acted as a cancer-promoting circRNA in TC by regulating the miR-431-5p/TGFA axis. 3 Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker. hsa_circ_0072309 hsa_circ_LIFR - DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" down-regulated Hsa_circ_0072309 is a novel potential risk biomarker of TNBC. 2 Circ-BICC1 Knockdown Alleviates Lipopolysaccharide (LPS)-Induced WI-38 Cell Injury Through miR-338-3p/MYD88 Axis. - hsa_circ_BICC1 Circ-BICC1 DOID:10533 viral pneumonia infantile pneumonia RT-qPCR up-regulated Circ-BICC1 silencing remitted LPS-triggered WI-38 cell damage by adsorbing miR-338-3p and regulating MYD88. 1 "Circ_0060,144 inhibits the occurrence and development of age-related cataract via the miR-23b-3p/HIPK3 axis." hsa_circ_0060144 - "Circ_0060,144" DOID:0070353 cataract age-related cataract RT-qPCR down-regulated "Circ_0060,144 promoted ARC development via regulation of miR-23b-3p/HIPK3 axis." 1 CircUBR5 acts as a ceRNA for miR-1179 to up-regulate UBR5 and to promote malignancy of triple-negative breast cancer. hsa_circ_0001819 hsa_circ_UBR5 circUBR5 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated CircUBR5 acts as a ceRNA for miR-1179 to up-regulate UBR5 and to promote malignancy of triple-negative breast cancer. 1 CircNRIP1 acts as a sponge of miR-1200 to suppress osteosarcoma progression via upregulation of MIA2. - hsa_circ_NRIP1 CircNRIP1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated circNRIP1 OS-suppressive role by sponge of miR-1200 expression and in turn to upregulate MIA2 expression. 2 Hsa_circ_0007312 Promotes Third-Generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance through Pyroptosis and Apoptosis via the MiR-764/MAPK1 Axis in Lung Adenocarcinoma Cells. hsa_circ_0007312 hsa_circ_SPECC1L circ_0007312 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated the inhibition of circ7312 decreased osimertinib resistance by promoting pyroptosis and apoptosis via the miR-764/MAPK1 axis. 1 Hypoxia-inducible CircPFKFB4 Promotes Breast Cancer Progression by Facilitating the CRL4(DDB2) E3 Ubiquitin Ligase-mediated p27 Degradation. - hsa_circ_PFKFB4 CircPFKFB4 DOID:1612 breast cancer breast cancer microarray up-regulated "HIF1alpha bound to hypoxia response elements in the promoter region of the PFKFB4 gene to facilitate the biogenesis of circPFKFB4 under hypoxia. Hypoxia-induced circPFKFB4 directly bound to both DDB1 and DDB2 and promoted the CRL4(DDB2) E3 ubiquitin ligase assembly, resulting in p27 ubiquitination and BC progression under hypoxia." 1 Circ_0110940 Exerts an Antiapoptotic and Pro-Proliferative Effect in Gastric Cancer Cells via the miR-1178-3p/SLC38A6 Axis. hsa_circ_0110940 - Circ_0110940 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circ_0110940 exerted an antiapoptotic and pro-proliferative effect in gastric cancer cells via the miR-1178-3p/SLC38A6 axis. 1 Hsa_circ_0093884 bound to RNA-binding protein RPS3 ameliorates hepatocyte inflammation in anti-tuberculosis drug-induced liver injury by competitively activating SIRT1. hsa_circ_0093884 - circ_0093884 DOID:409 liver disease Anti-tuberculosis drug-induced liver injury RT-qPCR down-regulated hsa_circ_0093884 regulates SIRT1 expression and inhibits the inflammatory response by binding to RPS3 in ADLI. 1 Exosomal circWDR62 promotes temozolomide resistance and malignant progression through regulation of the miR-370-3p/MGMT axis in glioma. - hsa_circ_WDR62 circWDR62 DOID:0060108 brain glioma glioma "RT-qPCR, microarray" up-regulated exosome-mediated delivery of circWDR62 can promote TMZ resistance and malignant progression via targeting of the miR-370-3p/MGMT axis in vitro and in vivo in glioma. 1 CircRNA-PTPRA Knockdown Inhibits Atherosclerosis Progression by Repressing ox-LDL-Induced Endothelial Cell Injury via Sponging of miR-671-5p. - hsa_circ_PTPRA CircRNA-PTPRA DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated circRNA-PTPRA downregulation protects against ox-LDL-induced HUVECs injury by upregulating miR-671-5p. 1 Effect of Solanum lyratum Polysaccharide on Malignant Behaviors of Lung Cancer Cells by Regulating the Circ_UHRF1/miR-513b-5p Axis. - hsa_circ_UHRF1 Circ_UHRF1 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "S. lyratum polysaccharide could inhibit the proliferation, migration and invasion of lung cancer A549 cells, and induce cell apoptosis. Its mechanism may be related to the regulation of the circ_UHRF1/miR-513b-5p axis." 1 "Circ_0067717 promotes colorectal cancer cell growth, invasion and glutamine metabolism by serving as a miR-497-5p sponge to upregulate SLC7A5." hsa_circ_0067717 - Circ_0067717 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circ_0067717 facilitated CRC development depending on the regulation of the miR-497-5p/SLC7A5 axis. 1 hsa_circ_0067514 suppresses gastric cancer progression and glycolysis via miR-654-3p/LATS2 axis. hsa_circ_0067514 hsa_circ_CEP70 circ_0067514 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated circ_0067514 suppressed gastric cancer aggressive development and glycolysis via miR-654-3p/LATS2 axis. 1 Urinary exosomes derived circRNAs as biomarkers for chronic renal fibrosis. hsa_circ_0036649 - hsa_circ_0036649 DOID:784 chronic kidney disease chronic renal disease microarray down-regulated Expression of urinary exosomes derived hsa_circ_0036649 associated with the degree of renal fibrosis. 1 CircRNA mmu_circ_0000021 regulates microvascular function via the miR-143-3p/NPY axis and intracellular calcium following ischemia/reperfusion injury. mmu_circ_0000021 - mmu_circ_0000021 DOID:936 brain disease ischemia-reperfusion "RT-qPCR, RNA-seq" dysregulated mmu_circ_0000021 involved in regulating microvascular dysfunction via miR-143-3p by targeting NPY. 1 "Novel roles of LSECtin in gastric cancer cell adhesion, migration, invasion, and lymphatic metastasis." - hsa_circ_FBXL4 circFBXL4 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" dysregulated LSECtin might be involved in the lymphatic metastasis of GC by upregulating the expression of FN1 and CHD4 via the circFBXL4/miR-146a-5p/STAT1 axis. 1 Circular RNA circLDLR facilitates cancer progression by altering the miR-30a-3p/SOAT1 axis in colorectal cancer. - hsa_circ_LDLR circLDLR DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circLDLR participates in CRC tumorigenesis and metastasis via the miR-30a-3p/SOAT1 axis. 1 Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma. hsa_circ_0066903 hsa_circ_GSK3B Circ-GSK3B DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated circ-GSK3B suppressed LUAD development through up-regulating and activating GSK3B. 1 Hsa_circ_0030042 Ameliorates Oxidized Low-Density Lipoprotein-Induced Endothelial Cell Injury via the MiR-616-3p/RFX7 Axis. hsa_circ_0030042 hsa_circ_FOXO1 circ_0030042 DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated Circ_0030042 weakened ox-LDL-induced HUVEC injury by regulating the miR-616-3p/RFX7 pathway. 2 circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3. - hsa_circ_CYP24A1 circCYP24A1 DOID:10283 prostate cancer prostate cancer RNA-seq dysregulated circCYP24A1 could be a promising biomarker to predict DTX response. 1 LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer. - hsa_circ_GFRA1 circGFRA1 DOID:10283 prostate cancer prostate cancer microarray up-regulated LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer. 1 Investigation of the Mechanism of hsa_circ_000 1429 Adsorbed miR-205 to Regulate KDM4A and Promote Breast Cancer Metastasis. hsa_circ_0001429 hsa_circ_MANBA - DOID:1612 breast cancer breast cancer RT-qPCR dysregulated hsa_circ_000 1429 may upregulate the KDM4A gene by adsorbing miR-205. 1 "Circular RNA 0001666 inhibits colorectal cancer cell proliferation, invasion and stemness by inactivating the Wnt/beta-catenin signaling pathway and targeting microRNA-1229." hsa_circ_0001666 - circ_0001666 DOID:9256 colorectal cancer colorectal cancer RT-qPCR dysregulated "circ_0001666 suppresses CRC cell proliferation, invasion and stemness by inhibiting the Wnt/beta-catenin signaling pathway by targeting miR-1229." 2 circ_0041732 Promotes Breast Cancer Progression. hsa_circ_0041732 - circ_0041732 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "E2F4-mediated circ_0041732 upregulation resulted in the activation of NFkappaB and Hedgehog pathways via sponging miR-541-3p and enhancing expression levels of c, thus affecting breast cancer cell proliferation, cell cycle, and cell apoptosis." 2 Hsa_circ_0000285 knockdown inhibits the progression of hepatocellular carcinoma by sponging miR-582-3p to regulate CCNB2 expression. hsa_circ_0000285 hsa_circ_HIPK3 circ_0000285 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated hsa_circ_0000285 fosters the development of malignant HCC cells phenotypes through the modulation of the miR-582-3p/CCNB2 axis. 6 "Vimentin binds to a novel tumor suppressor protein, GSPT1-238aa, encoded by circGSPT1 with a selective encoding priority to halt autophagy in gastric carcinoma." - hsa_circ_GSPT1 circGSPT1 DOID:10534 stomach cancer gastric cancer RNA-seq down-regulated "Vimentin binds to a novel tumor suppressor protein, GSPT1-238aa, encoded by circGSPT1 with a selective encoding priority to halt autophagy in gastric carcinoma." 1 "Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway." - hsa_circ_POLR2A circPOLR2A DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated "circPOLR2A modulated the UBE3C-mediated ubiquitination and degradation of the PEBP1 protein, and further activated the ERK pathway during cRCC progression and metastasis." 1 CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p. hsa_circ_0007624 hsa_circ_BCAR3 CircBCAR3 DOID:5041 esophageal cancer esophageal cancer "RT-qPCR, microarray" up-regulated "splicing factor QKI promotes circBCAR3 biogenesis, which accelerates esophageal cancer tumorigenesis via binding with miR-27a-3p to upregulate TNPO1." 1 RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial-myometrial interface. hsa_circ_0002144 hsa_circ_MAPK8 - DOID:13736 uterine inflammatory disease eutopic endometrium and endometrial-myometrial interface RNA-seq up-regulated hsa_circ_0002144 and hsa_circ_0005806 as co-upregulated and hsa_circ_0079536 and hsa_circ_0024766 as co-downregulated in the eutopic endometrium and EMI. 1 RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial-myometrial interface. hsa_circ_0005806 hsa_circ_FBRS - DOID:13736 uterine inflammatory disease eutopic endometrium and endometrial-myometrial interface RNA-seq up-regulated hsa_circ_0002144 and hsa_circ_0005806 as co-upregulated and hsa_circ_0079536 and hsa_circ_0024766 as co-downregulated in the eutopic endometrium and EMI. 1 RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial-myometrial interface. hsa_circ_0079536 hsa_circ_ITGB8 - DOID:13736 uterine inflammatory disease eutopic endometrium and endometrial-myometrial interface RNA-seq down-regulated hsa_circ_0002144 and hsa_circ_0005806 as co-upregulated and hsa_circ_0079536 and hsa_circ_0024766 as co-downregulated in the eutopic endometrium and EMI. 1 RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial-myometrial interface. hsa_circ_0024766 hsa_circ_STT3A - DOID:13736 uterine inflammatory disease eutopic endometrium and endometrial-myometrial interface RNA-seq down-regulated hsa_circ_0002144 and hsa_circ_0005806 as co-upregulated and hsa_circ_0079536 and hsa_circ_0024766 as co-downregulated in the eutopic endometrium and EMI. 1 The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition. - hsa_circ_ARAP2 circ-ARAP2 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated Abnormal circ-ARAP2 expression promoted ESCC progression by regulating miR-761/FOXM1 axis-mediated stemness and EMT. 1 Exosomes loaded with circPARD3 promotes EBV-miR-BART4-induced stemness and cisplatin resistance in nasopharyngeal carcinoma side population cells through the miR-579-3p/SIRT1/SSRP1 axis. - hsa_circ_PARD3 circPARD3 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated Exosomes loaded with circPARD3 promoted EBV-miR-BART4-induced stemness and cisplatin resistance in NPC-SP cells through the miR-579-3p/SIRT1/SSRP1 axis. 1 Circular RNA circ_0006089 promotes the progression of gastric cancer by regulating the miR-143-3p/PTBP3 axis and PI3K/AKT signaling pathway. hsa_circ_0006089 - circ_0006089 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_0006089 regulated miR-143-3p/PTBP3/PI3K/AKT pathway to facilitate GC progression. 4 CircFAT1 Promotes Lung Adenocarcinoma Progression by Sequestering miR-7 from Repressing IRS2-ERK-mediated CCND1 Expression. - hsa_circ_FAT1 CircFAT1 DOID:3910 lung adenocarcinoma lung adenocarcinoma RNA-seq up-regulated "circFAT1 promote tumorigenesis in LUAD through sequestering miR-7, consequently upregulating IRS2-ERK1/2-mediated CCND1 expression." 1 Integrated Analysis of circRNA-miRNA-mRNA-Mediated Network and Its Potential Function in Atrial Fibrillation. hsa_circ_0070391 hsa_circ_KLHL8 - DOID:0060224 atrial fibrillation atrial fibrillation RT-qPCR up-regulated "the plasmas hsa_circ_0070391 expression level was confirmed to be upregulated and positively correlated with left atrial fibrosis in AF , whereas hsa_circ_0003935 was downregulated. " 1 Integrated Analysis of circRNA-miRNA-mRNA-Mediated Network and Its Potential Function in Atrial Fibrillation. hsa_circ_0003935 hsa_circ_CACNA1A - DOID:0060224 atrial fibrillation atrial fibrillation RT-qPCR down-regulated "the plasmas hsa_circ_0070391 expression level was confirmed to be upregulated and positively correlated with left atrial fibrosis in AF , whereas hsa_circ_0003935 was downregulated. " 1 Circular RNA circACAP2 Suppresses Ferroptosis of Cervical Cancer during Malignant Progression by miR-193a-5p/GPX4. - hsa_circ_ACAP2 circACAP2 DOID:4362 cervical cancer cervical cancer RT-qPCR dysregulated circACAP2 repressed ferroptosis of cervical cancer during malignant progression by miR-193a-5p/GPX4. 1 CircKIF5B Promotes Hepatocellular Carcinoma Progression by Regulating the miR-192 Family/XIAP Axis. - hsa_circ_KIF5B CircKIF5B DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circKIF5B can regulate XIAP expression by sponging miR-192 and miR-215 competing for the ceRNA mechanism. 1 Immunomodulatory functions of the circ_001678/miRNA-326/ZEB1 axis in non-small cell lung cancer via the regulation of PD-1/PD-L1 pathway. - - circ_001678 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RNA-seq up-regulated circ_001678 sponges miR-326 to up-regulate ZEB1 expression and induce the PD-1/PD-L1 pathway-dependent immune escape. 1 "Circ_0060055 Promotes the Growth, Invasion, and Radioresistance of Glioblastoma by Targeting MiR-197-3p/API5 Axis." hsa_circ_0060055 - Circ_0060055 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated circ_0060055 contributed to GBM progression and radioresistance through miR-197-3p/API5 pathway. 1 hsa_circ_0092339 acts as a molecular sponge in castration-resistant prostate cancer via the hsa-mir-940/C-MYC axis. hsa_circ_0092339 hsa_circ_RABGGTB circ_0092339 DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" up-regulated hsa_circ_0092339 plays a critical role in CRPC through targeting C-MYC indirectly by absorbing hsa-mir-940. 1 "circ_0000045 promotes proliferation, migration, and invasion of head and neck squamous cell carcinomas via regulating HSP70 and MAPK pathway." hsa_circ_0000045 - circ_0000045 DOID:5520 head and neck squamous cell carcinoma head and neck squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "The high expression of circ_0000045; therefore, promoted cell proliferation, migration, and invasion during HNSCCs development through regulating HSP70 protein and mitogen-activated protein kinase signaling." 1 Exosome-Derived Circ_0094343 Promotes Chemosensitivity of Colorectal Cancer Cells by Regulating Glycolysis via the miR-766-5p/TRIM67 Axis. hsa_circ_0094343 - Circ_0094343 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "circ_0094343 inhibited the proliferation, clone formation and glycolysis of CRC cells and improved their chemosensitivity to various chemotherapeutic drugs via the miR-766-5p/TRIM67 axis." 2 Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR-876-3p. hsa_circ_0097922 - circ_0097922 DOID:1612 breast cancer breast cancer RT-qPCR dysregulated Hsa_circ_0097922 might regulate BC cell malignant behaviour and tamoxifen resistance partly by regulating the miR-876-3p/ACTN4 axis. 1 Knockdown of Circ_0000798 Impedes Cell Growth and Motility of Renal Cell Carcinoma Cells Through Functioning as miRNA Sponge for miR-589-5p. hsa_circ_0000798 hsa_circ_BPTF circ_0000798 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated Circ_0000798 might function oncogenic role in RCC and its downregulation could combat RCC cell growth and motility via targeting miR-589-5p/G3BP1 axis. 1 CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma. hsa_circ_0017114 - CircGPR137B DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated circGPR137B inhibits HCC tumorigenesis and metastasis through the circGPR137B/miR-4739/FTO feedback loop. 1 CircRNA circ_0005273 contributes to the cisplatin resistance of cervical cancer cells by sponging miR-133b. hsa_circ_0005273 - circ_0005273 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Circ_0005273 contributes to the DDP resistance of CC cells via sponging miR-133b. 1 The malignant property of circHIPK2 for angiogenesis and chemoresistance in non-small cell lung cancer. - hsa_circ_HIPK2 circHIPK2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circHIPK2 has the malignant property for angiogenesis and chemoresistance in NSCLC via the network of miR-1249-3p/VEGFA. 1 Engineered exosome-mediated delivery of circDIDO1 inhibits gastric cancer progression via regulation of MiR-1307-3p/SOCS2 Axis. - hsa_circ_DIDO1 circDIDO1 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated circDIDO1 suppressed the progression of GC via modulating the miR-1307-3p/SOSC2 axis. 2 Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer. - hsa_circ_HP1BP3 cHP1BP3 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer. 1 Screening of Human Circular RNAs as Biomarkers for Early Onset Detection of Alzheimer Disease. - - circRNA_001481 DOID:10652 Alzheimer disease Alzheimer disease microarray dysregulated circRNA_001481 and circRNA_000479 could be utilized as potential biomarkers for the early onset detection of AD and the development of effective therapeutics. 1 Screening of Human Circular RNAs as Biomarkers for Early Onset Detection of Alzheimer Disease. - - circRNA_000479 DOID:10652 Alzheimer disease Alzheimer disease microarray dysregulated circRNA_001481 and circRNA_000479 could be utilized as potential biomarkers for the early onset detection of AD and the development of effective therapeutics. 1 CircCTNNA1 is Upregulated in Mantle Cell Lymphoma and Predicts Poor Survival by Sponging miR-34a to Increase Cell Proliferation. - hsa_circ_CTNNA1 CircCTNNA1 DOID:0050746 mantle cell lymphoma mantle cell lymphoma RT-qPCR up-regulated Upregulation of circCTNNA1 in MCL predicts poor survival of patients and it may sponge miR-34a to promote cancer cell proliferation. 1 CircLONP2 Accelerates Esophageal Squamous Cell Carcinoma Progression via Direct MiR-27b-3p-ZEB1 Axis. - hsa_circ_LONP2 CircLONP2 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq, microarray" up-regulated circLONP2/miR-27b-3p/ZEB1 axis promotes ESCC metastasis via regulating epithelial-to-mesenchymal transition (EMT)-related protein. 1 Upregulation of Circ_0035266 Contributes to the Malignant Progression of Inflammation-Associated Malignant Transformed Cells Induced by Tobacco-Specific Carcinogen NNK. hsa_circ_0035266 - Circ_0035266 DOID:850 lung disease cigarette smoking-induced chronic inflammation RT-qPCR dysregulated Upregulation of Circ_0035266 Contributes to the Malignant Progression of Inflammation-Associated Malignant Transformed Cells Induced by Tobacco-Specific Carcinogen NNK. 1 Circ_0000520 interacts with miR-512-5p to upregulate KIAA0100 to promote malignant behaviors in lung cancer. hsa_circ_0000520 - Circ_0000520 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated circ_0000520 was able to drive the progression of lung cancer via the mediation of miR-512-5p/KIAA0100 axis. 1 Circ_0004676 exacerbates triple-negative breast cancer progression through regulation of the miR-377-3p/E2F6/PNO1 axis. hsa_circ_0004676 - Circ_0004676 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0004674 favors TNBC progression by regulating the miR-377-3p/E2F6/PNO1 axis. 1 UPF1/circRPPH1/ATF3 feedback loop promotes the malignant phenotype and stemness of GSCs. - hsa_circ_RPPH1 circRPPH1 DOID:3073 brain glioblastoma multiforme glioblastoma multiforme RT-qPCR up-regulated UPF1/circRPPH1/ATF3 maintains the potential self-renewal of GSCs through interacting with RNA-binding protein and activating the TGF-beta signal pathway. 1 Exosomal circPABPC1 promotes colorectal cancer liver metastases by regulating HMGA2 in the nucleus and BMP4/ADAM19 in the cytoplasm. - hsa_circ_PABPC1 circPABPC1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated exosomal circPABPC1 is an essential regulator in CRC liver metastasis progression by promoting HMGA2 and BMP4/ADAM19 expression. 1 Circ_0068087 Promotes High Glucose-Induced Human Renal Tubular Cell Injury through Regulating miR-106a-5p/ROCK2 Pathway. hsa_circ_0068087 - Circ_0068087 DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated circ_0068087 downregulation mitigated HG-induced HK2 cell injury through the miR-106a-5p/ROCK2 axis. 2 Circ_0010235 Regulates HOXA10 Expression to Promote Malignant Phenotypes and Radioresistance in Non-small Cell Lung Cancer Cells Via Decoying miR-588. hsa_circ_0010235 - Circ_0010235 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0010235 contributed to the malignant progression of NSCLC, but suppressed the radiation sensitivity via targeting miR- 588 to induce HOXA10 upregulation." 4 RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis. hsa_circ_0070562 hsa_circ_TET2 - DOID:7147 ankylosing spondylitis ankylosing spondylitis "RT-qPCR, RNA-seq" up-regulated Circ_0070562 functioned as a pro-ostegenic factor and might serve as a potential biomarker and a therapeutic target for AS. 1 "Deregulation of CircANXA2, Circ0075001, and CircFBXW7 Gene Expressions and Their Predictive Value in Egyptian Acute Myeloid Leukemia Patients." - hsa_circ_ANXA2 CircANXA2 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "CircANXA2, circ0075001, and circFBXW7 gene expressions could serve as potential diagnostic biomarkers for AML disease." 1 "Deregulation of CircANXA2, Circ0075001, and CircFBXW7 Gene Expressions and Their Predictive Value in Egyptian Acute Myeloid Leukemia Patients." - - circ007500 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "CircANXA2, circ0075001, and circFBXW7 gene expressions could serve as potential diagnostic biomarkers for AML disease." 1 "Deregulation of CircANXA2, Circ0075001, and CircFBXW7 Gene Expressions and Their Predictive Value in Egyptian Acute Myeloid Leukemia Patients." - hsa_circ_FBXW7 circFBXW7 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR down-regulated "CircANXA2, circ0075001, and circFBXW7 gene expressions could serve as potential diagnostic biomarkers for AML disease." 1 Circ_0005918 Sponges miR-622 to Aggravate Intervertebral Disc Degeneration. hsa_circ_0005918 - Circ_0005918 DOID:90 degenerative disc disease Intervertebral discdegeneration RT-qPCR up-regulated circ_0005918 played important roles in the development of IDD via sponging miR-622. 1 hsa_circ_0000518 Facilitates Non-Small-Cell Lung Cancer Progression via Moderating miR-330-3p and Positively Regulating SLC1A5. hsa_circ_0000518 hsa_circ_RPPH1 circ_0000518 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "circ_0000518 may have a prooncogenic function in the formation and progression of NSCLC, which might be achieved through moderating the miR-330-3p/SLC1A5 axis." 2 "Identification, biogenesis, and function prediction of a novel circRNA_3238 of chicken." - - circRNA_3238 DOID:4492 avian influenza ALV-J infection RNA-seq dysregulated circRNA_3238 may indirectly regulate the process of ALV-J infection by regulating target genes. 1 Circular RNA circ-TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA. - hsa_circ_TNPO3 Circ-TNPO3 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, microarray" down-regulated Circ-TNPO3 can suppress ccRCC progression and metastasis via directly binding to IGF2BP2 protein and destabilizing SERPINH1 mRNA. 1 "hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 can be combined as biomarkers in type 2 diabetes mellitus." hsa_circ_0071106 hsa_circ_ARHGAP10 circ_0071106 DOID:9352 type 2 diabetes mellitus type 2 diabetes mellitus RT-qPCR up-regulated "hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 can be combined as biomarkers in type 2 diabetes mellitus." 1 Berberine inhibits the development of endometrial cancer through circ_ZNF608/miR-377-3p/COX2 axis. - hsa_circ_ZNF608 circ_ZNF608 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated BBR was found to inhibit EC via the circ_ZNF608/miR-377-3p/COX2 axis. 1 Circ_0057452 sponges miR-7-5p to promote keloid progression through upregulating GAB1. hsa_circ_0057452 - Circ_0057452 DOID:10881 "hand, foot and mouth disease" keloid RT-qPCR up-regulated Circ_0057452 knockdown suppressed keloid development by regulating miR-7-5p/GAB1 axis. 2 "Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis." - hsa_circ_ROCK1-E3/E circROCK1-E3/E DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis." 1 "Circ_0005714/miR-223-3p/ADAM9 regulatory axis affects proliferation, migration, invasion, and angiopoiesis in trophoblast cells." hsa_circ_0005714 - Circ_0005714 DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated circ_0005714 retarded the progression of PE by mediating the miR-223-3p/ADAM9 signal network. 1 Circ_0049472 regulates the damage of Abeta-induced SK-N-SH and CHP-212 cells by mediating the miR-107/KIF1B axis. hsa_circ_0049472 - Circ_0049472 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated "Circ_0049472 modulated KIF1B by serving as a miR-107 decoy, thereby mediating Abeta-induced neurotoxicity." 1 Peripheral Circular RNA Profiling from Patients with Allergic Rhinitis Identified hsa_circRNA_404013 as a Potential Diagnostic Biomarker. - - hsa_circRNA_404013 DOID:4481 allergic rhinitis allergic rhinitis "RT-qPCR, microarray" up-regulated sa_circRNA_404013 may regulate the expression level of BDNF through hsa-mir-182-5p in AR pathogenesis. 1 Profile of TREM2-Derived circRNA and mRNA Variants in the Entorhinal Cortex of Alzheimer Disease Patients. - hsa_circ_TREM2_1 circTREM2_1 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, RNA-seq" up-regulated "A novel circRNA derived from the TREM2 gene, circTREM2_1, has been identified in the human entorhinal cortex and TREM2 mRNA expression has been detected to increase in AD compared to controls." 1 Circ_0018168 inhibits the proliferation and osteogenic differentiation of fibroblasts in ankylosing spondylitis via regulating miR-330-3p/DKK1 axis. hsa_circ_0018168 - Circ_0018168 DOID:7147 ankylosing spondylitis ankylosing spondylitis RT-qPCR down-regulated Circ_0018168 overexpression restrained fibroblast proliferation and osteogenic differentiation in AS by elevating DKK1 through adsorbing miR-330-3p. 1 Circ-NCX1 inhibits LPS-induced chondrocyte apoptosis by regulating the miR-133a/SIRT1 axis. - hsa_circ_NCX1 Circ-NCX1 DOID:8398 osteoarthritis osteoarthritis RT-qPCR dysregulated circ-NCX1 may serve as an important regulator of LPS-induced chondrocyte apoptosis through the miR-133a/Sirt1 axis. 1 Circ_0008768 Suppresses the Pancreatic Cancer Progression via miR-330- 3p/PTEN Axis. hsa_circ_0008768 - Circ_0008768 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR down-regulated circ_0008768 can act as a tumor-suppressive factor to inhibit the development of PC by regulating the miR-330-3p/PTEN molecular axis. 1 Hsa_circ_0079530/AQP4 Axis Is Related to Non-Small Cell Lung Cancer Development and Radiosensitivity. hsa_circ_0079530 hsa_circ_TWIST1 circ_0079530 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0079530 silence repressed cell proliferation, migration, and invasion, and facilitated radiosensitivity in NSCLC cells by mediating miR-409-3p/AQP4 axis." 3 CircWDR26 regulates endometrial carcinoma progression via miR-212-3p-mediated typing genes MSH2. - hsa_circ_WDR26 CircWDR26 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated circWDR26 promoted EC progression by regulating miR-212-3p/MSH2 axis. 4 Hsa_circ_0008092 Contributes to Cell Proliferation and Metastasis in Hepatocellular Carcinoma via the miR-502-5p/CCND1 Axis. hsa_circ_0008092 hsa_circ_CORO1C circ_0008092 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ_0008092 promotes HCC progression by regulating the miR- 502-5p/CCND1 axis. 3 Knockdown of circ_0004585 enhances the chemosensitivity of colorectal cancer cells to 5-fluorouracil via the miR-874-3p/CCND1 axis. hsa_circ_0004585 - circ_0004585 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0004585 promotes the development of CRC and increases 5-FU resistance in CRC through the miR-874-3p/CCND1 axis. 3 "A novel identified circular RNA, circSnap47, promotes heart failure progression via regulation of miR-223-3p/MAPK axis." - hsa_circ_Snap47 circSnap47 DOID:114 heart disease heart failure RT-qPCR up-regulated circSnap47 silencing inhibited HF progression via regulation of miR-223/MAPK axis. 1 "A Circular RNA, hsa_circ_0018180 (circPARD3), Triggers Glycolysis and Promotes Malignancy of Head and Neck Squamous Cell Carcinoma Through the miR-5194/ENO1 Axis." hsa_circ_0018180 hsa_circ_PARD3 circPARD3 DOID:5520 head and neck squamous cell carcinoma head and neck squamous cell carcinoma RT-qPCR up-regulated "hsa_circ_0018180 (circPARD3), Triggers Glycolysis and Promotes Malignancy of Head and Neck Squamous Cell Carcinoma Through the miR-5194/ENO1 Axis." 1 Rapamycin inhibits the progression of human acute myeloid leukemia by regulating the circ_0094100/miR-217/ATP1B1 axis. hsa_circ_0094100 - circ_0094100 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated Rapamycin inhibited AML cell viability and cell cycle process and induced apoptosis through regulation of the circ_0094100/miR-217/ATP1B1 axis. 1 "CircPDSS1 promotes the proliferation, invasion, migration, and EMT of breast cancer cell via regulating miR-320c/CKAP5 axis." - hsa_circ_PDSS1 CircPDSS1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "CircPDSS1 promotes proliferation, invasion, migration as well as EMT of BC cells by modulating miR-320c/CKAP5 axis." 1 Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer. hsa_circ_0000144 - Circ_0000144 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "Circ_0000144 promoted cell malignancy and angiogenesis by regulating the miR-1178-3p/YWHAH axis in PTC, offering a novel mechanism for the malignancy and angiogenesis of PTC cells." 1 "Knockdown of circ_0025908 inhibits proliferation, migration, invasion, and inflammation while stimulates apoptosis in fibroblast-like synoviocytes by regulating miR-650-dependent SCUBE2." hsa_circ_0025908 - circ_0025908 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated Circ_0025908 inhibition can suppress FLS-RA dysfunctions through targeting miR-650/SCUBE2 axis. 2 Knockdown of hsa_circ_0005699 attenuates inflammation and apoptosis induced by ox-LDL in human umbilical vein endothelial cells through regulation of the miR-450b-5p/NFKB1 axis. hsa_circ_0005699 hsa_circ_C16orf62 circ_0005699 DOID:1936 atherosclerosis atherosclerosis RT-qPCR dysregulated knockdown of circ_0005699 may ameliorate endothelial cell injury through regulation of the miR-450b-5P/NFKB1 signaling axis. 3 Circ_0008287 promotes immune escape of gastric cancer cells through impairing microRNA-548c-3p-dependent inhibition of CLIC1. hsa_circ_0008287 - Circ_0008287 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_0008287 promotes immune escape of gastric cancer cells through impairing microRNA-548c-3p-dependent inhibition of CLIC1. 1 Circular RNA circPBX3 promotes cisplatin resistance of ovarian cancer cells via interacting with IGF2BP2 to stabilize ATP7A mRNA expression. - hsa_circ_PBX3 circPBX3 DOID:2394 ovarian cancer ovarian cancer RNA-seq up-regulated silencing ATP7A in ovarian cancer cells abrogated the effect of circPBX3 overexpression on cisplatin tolerance. 1 Suppression of circXPO1 attenuates cigarette smoke-induced inflammation and cellular senescence of alveolar epithelial cells in chronic obstructive pulmonary disease. - hsa_circ_XPO1 circXPO1 DOID:3083 chronic obstructive pulmonary disease chronic obstructive pulmonary disease RT-qPCR up-regulated circXPO1 plays a role in the pathogenesis of COPD by modulating TAB3 through sponging miR-23b-3p. 1 Hsa_circ_0129047 regulates the miR-375/ACVRL1 axis to attenuate the progression of lung adenocarcinoma. hsa_circ_0129047 - circ_0129047 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated hsa_circ_0129047 functions as a tumor inhibitor in LUAD by modulating the miR-375/ACVRL1 axis. 2 Re-expression of circ_0043610 contributes to trophoblast dysfunction through the miR-558/RYBP pathway in preeclampsia. hsa_circ_0043610 - circ_0043610 DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated Circ_0043610 induced RYBP production to promote trophoblast dysfunction by binding to miR-558 in PE. 1 hsa_circ_0084811 Regulates Cell Proliferation and Apoptosis in Retinoblastoma through miR-18a-5p/miR-18b-5p/E2F5 Axis. hsa_circ_0084811 hsa_circ_E2F5 - DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated circ_0084811 modulated retinoblastoma progression via the miR-18a-5p/miR-18b-5p/E2F5 axis. 1 Effects of circFOXO3 on the Proliferation and Invasion of Liver Cancer Cells by Regulating PI3K/Akt Pathway. - hsa_circ_FOXO3 circFOXO3 DOID:3571 liver cancer liver cancer RT-qPCR down-regulated "Highly expressed circFOXO3 can inhibit the proliferation and invasion of HuH-7 liver cancer cells, which may be achieved by inhibiting the PI3K/Akt pathway." 1 Circ_0001821 Affects Proliferation and the Cell Cycle in Esophageal Squamous Cell Carcinoma by Elevating BTRC-Mediated IKBA Ubiquitination. hsa_circ_0001821 - Circ_0001821 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated Circ_0001821 Affects Proliferation and the Cell Cycle in Esophageal Squamous Cell Carcinoma by Elevating BTRC-Mediated IKBA Ubiquitination. 1 High Glucose-Induced Human Kidney Cell Apoptosis and Inflammatory Injury Are Alleviated by Circ_0008529 Knockdown via Circ_0008529-Mediated miR-485-5p/WNT2B Signaling. hsa_circ_0008529 - circ_0008529 DOID:9743 diabetic neuropathy diabetic nephropathy RT-qPCR up-regulated "Circ_0008529 targeted the miR-485-5p/WNT2B pathway to regulate HG-induced HK-2 cell apoptosis and inflammatory injury, suggesting that circ_0008529 was a vital regulator in DN development." 2 Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling. hsa_circ_0001005 - circ_0001005 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated ADAR2/circ_0001005/miR-200a-3p/PD-L1 pathway to impact antitumor immunity may suppress progression and boost immunotherapeutic efficacy in BCa. 1 Circular RNA circTTBK2 facilitates non-small-cell lung cancer malignancy through the miR-873-5p/TEAD1/DERL1 axis. - hsa_circ_TTBK2 circTTBK2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circular RNA circTTBK2 facilitates non-small-cell lung cancer malignancy through the miR-873-5p/TEAD1/DERL1 axis. 1 Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis. - hsa_circ_FNDC3B circFNDC3B DOID:50865 tongue squamous cell carcinoma oral tongue squamous cell carcinoma development RT-qPCR up-regulated The circFNDC3B/miR-1322/MED1 axis participates in OTSCC progression. 1 Circ_0035381 Regulates Acute Myeloid Leukemia Development by Modulating YWHAZ Expression via Adsorbing miR-582-3p. hsa_circ_0035381 - Circ_0035381 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated Circ_0035381 knockdown repressed cell proliferation and promoted cell apoptosis and mitochondrial damage via regulating the miR-582-3p/YWHAZ axis in AML. 2 CircIPO7 Promotes Nasopharyngeal Carcinoma Metastasis and Cisplatin Chemoresistance by Facilitating YBX1 Nuclear Localization. - hsa_circ_IPO7 CircIPO7 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, RNA-seq" up-regulated CircIPO7 Promotes Nasopharyngeal Carcinoma Metastasis and Cisplatin Chemoresistance by Facilitating YBX1 Nuclear Localization. 1 Circular RNA hsa_circ_0000317 inhibits non-small cell lung cancer progression through regulating microRNA-494-3p/phosphatase and tensin homolog deleted on chromosome 10 axis. hsa_circ_0000317 hsa_circ_AHNAK - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" down-regulated "Circ_0000317, inhibits NSCLC progression via modulating miR-494-3p/PTEN/PI3K/AKT pathway." 1 "Circ_0088194 Regulates Proliferation, Migration, Apoptosis, and Inflammation by miR-30a-3p/ADAM10 Axis in Rheumatoid Arthritis Fibroblastic Synovial Cells." hsa_circ_0088194 - Circ_0088194 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "Circ_0088194 acted on miR-30a-3p/ADAM10 axis to promote the proliferation, migration, and inflammatory response, and inhibit apoptosis in RA-FLSs." 1 Exosomes derived from myeloid-derived suppressor cells facilitate castration-resistant prostate cancer progression via S100A9/circMID1/miR-506-3p/MID1. hsa_circ_0007718 hsa_circ_MID1 - DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" up-regulated "Together, our results showed that a S100A9/circMID1/miR-506-3p/MID1 axis existed in MDSC-Exo-regulated CRPC progression, which provided novel insights into MDSC-Exo regulatory mechanisms in CRPC progression." 2 Circular RNA circLRCH3 promotes oxaliplatin resistance in gastric cancer through the modulation of the miR-383-5p/FGF7 axis. - hsa_circ_LRCH3 circLRCH3 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Knockdown of circLRCH3 alleviated OXA resistance of GC by modulating the miR-383-5p/FGF7 axis. 2 Circ-CBFB exacerbates hypoxia/reoxygenation-triggered cardiomyocyte injury via regulating miR-495-3p in a VDAC1-dependent manner. - hsa_circ_CBFB Circ-CBFB DOID:114 heart disease cardiomyocyte injury RT-qPCR up-regulated Circ-CBFB exacerbates hypoxia/reoxygenation-triggered cardiomyocyte injury via regulating miR-495-3p in a VDAC1-dependent manner. 1 Circ_0001955 promotes the progression of non-small cell lung cancer via miR-769-5p/EGFR axis. hsa_circ_0001955 hsa_circ_CSNK1G1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0001955 facilitates the proliferation and represses the apoptosis of NSCLC cells by modulating miR-769-5p/EGFR axis. 1 Circular RNA circFARSA promotes the tumorigenesis of non-small cell lung cancer by elevating B7H3 via sponging miR-15a-5p. hsa_circ_0000896 hsa_circ_FARSA - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" up-regulated "The present study demonstrated that circFRASA was upregulated in NSCLC tissues and cell lines, and its expression was positively correlated with poor prognosis of patients with NSCLC." 2 Down-Regulation of circCOL1A2 Suppresses the Dysfunction of Diabetes-Related Retinal Microvascular Endothelial Cells via miR-646/FGF7 Axis. - hsa_circ_COL1A2 circCOL1A2 DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR up-regulated "CircCOL1A2 silencing can suppress HG-induced migration, proliferation, angiogenesis, BRB injury and inflammation in RMECs through miR-646/FGF7 axis." 4 "Circ_DLEU2 knockdown represses cell proliferation, migration and invasion, and induces cell apoptosis through the miR-582-5p/COX2 pathway in acute myeloid leukemia." - hsa_circ_DLEU2 Circ_DLEU2 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated Circ_DLEU2 silencing hindered AML malignant progression via downregulating COX2 through sponging miR-582-5p. 2 Circ_0000011 promotes cerebral ischemia/reperfusion injury via miR-27a-3p-dependent regulation of NRIP1. hsa_circ_0000011 - Circ_0000011 DOID:326 ischemia cerebral ischemia/reperfusion injury RT-qPCR up-regulated Circ_0000011 promotes OGD/R-induced HT-22 cell impairments by elevating NRIP1 through sponging miR-27a-3p. 1 "Circ_0,007,331 Promotes the PTX Resistance and Progression of Breast Cancer via miR-200b-3p/ANLN." hsa_circ_0007331 - Circ_0007331 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_0,007,331 contributed to the PTX resistance, proliferation and motility and inhibited the apoptosis of BC cells through mediating miR-200b-3p/ANLN signaling." 1 Circular RNA circPOSTN promotes neovascularization by regulating miR-219a-2-3p/STC1 axis and stimulating the secretion of VEGFA in glioblastoma. - hsa_circ_POSTN circPOSTN DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated Circular RNA circPOSTN promotes neovascularization by regulating miR-219a-2-3p/STC1 axis and stimulating the secretion of VEGFA in glioblastoma. 1 circRPPH1_025 Overexpression Promotes Migration and Invasion of Glioblastoma Multiforme. - hsa_circ_RPPH1_025 circRPPH1_025 DOID:3073 brain glioblastoma multiforme glioblastoma Multiforme RT-qPCR up-regulated circRPPH1_025 Overexpression Promotes Migration and Invasion of Glioblastoma Multiforme. 1 "Circ_0000467 regulates proliferation, migration, invasion, and apoptosis in gastric cancer by targeting the miR-622/ROCK2 axis." hsa_circ_0000467 - Circ_0000467 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated circ_0000467 functioned as an oncogenic regulator in GC by specifically binding to miR-622 to upregulate ROCK2. 3 Exosomal circKDM4A Induces CUL4B to Promote Prostate Cancer Cell Malignancy in a miR-338-3p-Dependent Manner. - hsa_circ_KDM4A circKDM4A DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated Exosomal circKDM4A promoted PC malignant progression by the miR-338-3p/CUL4B axis. 1 Circ_0099630 Participates in SPRY1-Mediated Repression in Periodontitis. hsa_circ_0099630 - circ_0099630 DOID:824 periodontitis Periodontitis RT-qPCR down-regulated Circ_0099630 curbed PDLC proliferation and osteogenic differentiation through elevating SPRY1 expression via sponging miR-212-5p in periodontitis. 3 Hepatic stellate cell exosome-derived circWDR25 promotes the progression of hepatocellular carcinoma via the miRNA-4474-3P-ALOX-15 and EMT axes. - hsa_circ_WDR25 circWDR25 DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray down-regulated circWDR25 facilitated HCC cell proliferation and invasion via the circWDR25/miR-4474-3p/ALOX15 and EMT axes and it promoted the expression of CTLA-4 in HSCs and PD-L1 in HCC cells. 1 Hsa_circ_0102485 inhibits the growth of cancer cells by regulating the miR-188-3p/ARID5B/AR axis in prostate carcinoma. hsa_circ_0102485 - circ_0102485 DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated Hsa_circ_0102485 plays an inhibitory role in PCa by regulating the Mir-188-3p/ARID5B/AR axis. 1 Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1. hsa_circ_0000826 hsa_circ_ANKRD12 Circ_0000826 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1. 3 Circular BANP knockdown inhibits the malignant progression of residual hepatocellular carcinoma after insufficient radiofrequency ablation. - hsa_circ_BANP circ-BANP DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Knockdown of circ-BANP upregulated let-7f-5p to inhibit proliferation, migration, and EMT formation in residual HCC remaining after insufficient RFA. Effects occur via regulation of the TLR4/STAT3 signaling pathway." 2 Luteolin suppresses lung cancer progression through targeting the circ_0000190/miR-130a-3p/notch-1 signaling pathway. hsa_circ_0000190 - circ_0000190 DOID:1324 lung cancer lung cancer RT-qPCR dysregulated Luteolin dampened the progression of lung cancer partly by regulating circ_0000190/miR-130a-3p. 1 High Expression of circ_0001821 Promoted Colorectal Cancer Progression Through miR-600/ISOC1 Axis. hsa_circ_0001821 - circ_0001821 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0001821 regulated the developmental process of CRC through miR-600/ISOC1 axis. 3 CircKPNB1 mediates a positive feedback loop and promotes the malignant phenotypes of GSCs via TNF-alpha/NF-kappaB signaling. - hsa_circ_KPNB1 CircKPNB1 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated CircKPNB1 mediates a positive feedback loop and promotes the malignant phenotypes of GSCs via TNF-alpha/NF-kappaB signaling. 1 Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-kappaB signaling. - hsa_circ_NFKB1 circNFKB1 DOID:8398 osteoarthritis osteoarthritis RT-qPCR dysregulated "circNFKB1 interacted with alpha-enolase (ENO1), regulated the expression of its parental gene NFKB1 and sustained the activation of NF-kappaB signaling pathway in chondrocytes." 2 CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis. - hsa_circ_ST6GALNAC6 CircRNA-ST6GALNAC6 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated CircST6GALNAC6 inhibits HSPB1 and promotes cell ferroptosis by occupying the phosphorylation site (Ser-15) of HSBP1 and activating the P38 MAPK signaling pathway. 2 Circ_0001058 represses the progression of lung adenocarcinoma through governing of the miR-486-5p/TEK signaling axis. hsa_circ_0001058 - Circ_0001058 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated Circ_0001058 overexpression blocked the malignant development of lung adenocarcinoma via modulation of the miR-486-5p/TEK pathway. 1 Circular RNA circVPRBP serves as a microRNA-106b-5p sponge to regulate proliferation and metastasis of cervical cancer cells via tripartite motif-containing protein 3. - hsa_circ_VPRBP circVPRBP DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated CircVPRBP could inhibit the malignant biological behavior of cervical cancer cells by miR-106b-5p/TRIM3 axis. 4 Identification of exosomal circRNA CD226 as a potent driver of nonsmall cell lung cancer through miR-1224-3p/high mobility group AT-hook 2 axis. - hsa_circ_CD226 CircCD226 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circCD226 as a potential driver in NSCLC development depending on the regulation of miR-1224-3p/HMGA2 axis. 1 Circ_0061140 Facilitates Adenomyosis Progression by Upregulating LIN28B in vitro. hsa_circ_0061140 - Circ_0061140 DOID:288 endometriosis of uterus adenomyosis RT-qPCR up-regulated Circ_0061140 contributed to adenomyosis progression by binding to miR-141-3p to induce LIN28B expression in vitro. 2 Hsa_circ_0045932 regulates the progression of colorectal cancer by regulating HK2 through sponging miR-873-5p. hsa_circ_0045932 hsa_circ_USP36 circ_0045932 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Hsa_circ_0045932 promoted CRC progression through sponging miR-873-5p to up-regulate HK2. 1 Knockdown of circ_0002194 protects against oxidized low-density lipoprotein-induced cell damage via the regulation of the miR-637/PACS2 axis in human vascular endothelial cells. hsa_circ_0002194 - circ_0002194 DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated circ_0002194 facilitated endothelial cell dysfunction in atherosclerosis partly through upregulating PACS2 by targeting miR-637. 1 Down-regulation of hsa-circ-0107593 promotes osteogenic differentiation of hADSCs via miR-20a-5p/SMAD6 signaling. hsa_circ_0107593 - circ-0107593 DOID:12347 osteogenesis imperfecta osteogenesis "RT-qPCR, RNA-seq" down-regulated Knocking down hsa-circ-0107593 acts as a positive factor of the osteogenic differentiation of hADSCs via miR-20a-5p/SMAD6 signaling. 1 Hsa_circular RNA_0001013 exerts oncogenic effects in gastric cancer through the microRNA-136-TWSG1 axis. hsa_circ_0001013 - circ_0001013 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated circ_0001013 increased TWSG1 expression by binding to miR-136. 1 CircAGFG1 Promotes Osteosarcoma Progression and Stemness by Competing with miR-302a-3p to Upregulate the Expression of LATS2. - hsa_circ_AGFG1 CircAGFG1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated CircAGFG1 Promotes Osteosarcoma Progression and Stemness by Competing with miR-302a-3p to Upregulate the Expression of LATS2. 1 CircSHOC2 Knockdown Alleviates High Glucose-Induced Vascular Endothelial Cell Pyroptosis via Targeting miR-145/FOXO1 Axis In Vitro Condition. - hsa_circ_SHOC2 CircSHOC2 DOID:9351 diabetes mellitus cardiovascular system complications of diabetes RT-qPCR up-regulated CircSHOC2 Knockdown Alleviates High Glucose-Induced Vascular Endothelial Cell Pyroptosis via Targeting miR-145/FOXO1 Axis In Vitro Condition. 1 Circ_0003611 regulates apoptosis and oxidative stress injury of Alzheimer disease via miR-383-5p/KIF1B axis. hsa_circ_0003611 - Circ_0003611 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated circ_0003611 improved Abeta-triggered neuronal injury in AD through targeting the miR-383-5p/KIF1B axis. 3 The diagnostic value of has_circ_0006423 in non-small cell lung cancer and its role as a tumor suppressor gene that sponges miR-492. hsa_circ_0006423 hsa_circ_BCAR3 circ_0006423 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "hsa_circ_0006423 inhibited the proliferation, migration, and invasion of NSCLC cells by sponging miR-492 and accelerating NSCLC cell apoptosis." 2 The circRNA circADAMTS6 promotes progression of ESCC and correlates with prognosis. - hsa_circ_ADAMTS6 circADAMTS6 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated CircADAMTS6 may acts as oncogene by activating AGR2 and the Hippo signaling pathway coactivator YAP in ESCC. 1 Targeting circRNA-MAP4K2 for the treatment of diabetes-induced retinal vascular dysfunction. - hsa_circ_MAP4K2 circRNA-MAP4K2 DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR up-regulated "cMAP4K2 acted as miR-377 sponge to affect the biological activity of miR-377, which led to increased expression of vascular endothelial growth factor A (VEGFA)." 1 Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment. - hsa_circ_BIRC6 circBIRC6 DOID:824 periodontitis periodontitis RT-qPCR up-regulated "In summary, the expression of miR-543 is significantly increased following circBIRC6 downregulation, leading to inhibition of PTEN and subsequently activation of PI3K/AKT/mTOR signaling pathway. Therefore, targeting circBIRC6 might represent a potential therapeutic strategy for improving bone loss in periodontitis." 1 Circ_0008285 knockdown represses tumor development by miR-384/RRM2 axis in hepatocellular carcinoma. hsa_circ_0008285 - Circ_0008285 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ_0008285 could promote the malignant biological behaviors of HCC cells through miR-384/RRM2 axis and has the potential to become a therapeutic target for HCC. 1 Circular RNA circ-BNC2 (hsa_circ_0008732) inhibits the progression of ovarian cancer through microRNA-223-3p/ FBXW7 axis. hsa_circ_0008732 hsa_circ_BNC2 circ-BNC2 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated Circ-BNC2 suppresses the progression of OC via regulating miR-223-3p / FBXW7 axis. 2 Identification of the hsa_circ_0039466/miR-96-5p/FOXO1 regulatory network in hepatocellular carcinoma by whole-transcriptome analysis. hsa_circ_0039466 hsa_circ_MT1E circ_0039466 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" dysregulated "hsa_circ_0039466 facilitates the expression of FOXO1 by sponging miR-96-5p, and ultimately inhibits tumor progression." 1 CircHIPK2 promotes proliferation of nasopharyngeal carcinoma by down-regulating HIPK2. - hsa_circ_HIPK2 CircHIPK2 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, RNA-seq" up-regulated circHIPK2 facilitated the cell proliferation of NPC cells via the circHIPK2/HIPK2 axis. 1 Circ_0005758 impedes gastric cancer progression through miR-1229-3p/GCNT4 feedback loop. hsa_circ_0005758 - Circ_0005758 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Circ_0005758 acts as a tumor suppressor to impede gastric cancer progression via miR-1229-3p/GCNT4 axis. 2 Circulating circular RNA hsa_circ_0023179 acts as a diagnostic biomarker for non-small-cell lung cancer detection. hsa_circ_0023179 hsa_circ_LRP5 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" dysregulated hsa_circ_0023179 might be a promising novel serum marker for the detection and prediction of NSCLC. 1 CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson disease. - mmu_circ_SV2b CircSV2b DOID:14330 Parkinson disease Parkinson disease "RT-qPCR, RNA-seq" up-regulated "the miR-5107-5p-Foxk1-Akt1 axis might serve as a key target of circSV2b overexpression in PD treatment, and highlighted the significant change of circSV2b in serum exosomes." 1 CircRNA 0009043 suppresses non-small-cell lung cancer development via targeting the miR-148a-3p/DNAJB4 axis. hsa_circ_0009043 - circ_0009043 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0009043 acts as a tumor suppressor in NSCLC cells, promoting DNAJB4 upregulation via the sequestration of miR-148a-3p." 1 Circulating Exosomal circRNA_0063476 Impairs Expression of Markers of Bone Growth Via the miR-518c-3p/DDX6 Axis in ISS. hsa_circ_0063476 - circRNA_0063476 DOID:0112120 SHOX-related short stature Idiopathic short stature microarray dysregulated exosome-derived hsa_circ_0063476 retards the expression of markers of endochondral ossification and impairs longitudinal bone growth via miR-518c-3p/DDX6 axis. 1 The short inverted repeats-induced circEXOC6B inhibits prostate cancer metastasis by enhancing the binding of RBMS1 and HuR. - hsa_circ_EXOC6B circEXOC6B DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" down-regulated The short inverted repeats-induced circEXOC6B inhibits prostate cancer metastasis by enhancing the binding of RBMS1 and Hu. 1 circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and Inhibits the Development of Gastric Cancer with Cisplatin Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition. - hsa_circ_LDLRAD3 circ-LDLRAD3 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circ-LDLRAD3 knockdown reduced DDP resistance and blocked the malignant development of DDP-resistant GC by modulating the miR-588/SOX5 pathway. 1 CircZNF644 aggravates lipopolysaccharide-induced HK-2 cell impairment via the miR-140-5p/MLKL axis. - hsa_circ_ZNF644 CircZNF644 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated CircZNF644 knockdown protected HK-2 cells from LPS-induced injury by altering miR-140-5p/MLKL pathway. 2 Depletion of circ_0128846 ameliorates interleukin-1beta-induced human chondrocyte apoptosis and inflammation through the miR-940/PTPN12 pathway. hsa_circ_0128846 - circ_0128846 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Circ_0128846 regulated human chondrocyte proliferation, apoptosis and inflammation through the miR-940/PTPN12 pathway in OA." 2 circ-Katnal1 Enhances Inflammatory Pyroptosis in Sepsis-Induced Liver Injury through the miR-31-5p/GSDMD Axis. - hsa_circ_Katnal1 circ-Katnal1 DOID:0040085 bacterial sepsis sepsis RNA-seq up-regulated circ-Katnal1 enhanced inflammatory pyroptosis in sepsis-induced liver injury through the miR-31-5p/GSDMD axis. 1 "CircPTK2 promotes cell viability, cell cycle process, and glycolysis and inhibits cell apoptosis in acute myeloid leukemia by regulating miR-582-3p/ALG3 axis." - hsa_circ_PTK2 CircPTK2 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated CircPTK2 contributed to AML cell malignant behaviors by modulation of miR-582-3p/ALG3 axis. 2 Circular RNA hsa_circ_0002360 Promotes Proliferation and Invasion and Inhibits Oxidative Stress in Gastric Cancer by Sponging miR-629-3p and Regulating the PDLIM4 Expression. hsa_circ_0002360 hsa_circ_RUNX1 circ0002360 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circular RNA hsa_circ_0002360 Promotes Proliferation and Invasion and Inhibits Oxidative Stress in Gastric Cancer by Sponging miR-629-3p and Regulating the PDLIM4 Expression. 1 Nitroxoline suppresses metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway. - hsa_circ_NDRG1 circNDRG1 DOID:11054 urinary bladder cancer bladder cancer microarray dysregulated nitroxoline may suppress metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway. 1 Decrease of circARID1A retards glioblastoma invasion by modulating miR-370-3p/ TGFBR2 pathway. - hsa_circ_ARID1A circARID1A DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, microarray" up-regulated circARID1A participated in regulating migration and invasion of GBM via modulation of miR-370-3p/ TGFBR2 . 1 Circ_0004712 Silencing Suppresses the Aggressive Changes of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Targeting miR-633/TRAF6 Axis. hsa_circ_0004712 - circ_0004712 DOID:7148 rheumatoid arthritis Rheumatoid Arthritis RT-qPCR up-regulated "Circ_0004712 silencing inhibited the aggressive changes of RA-FLSs by targeting miR-633/TRAF6 axis and NF-¦ĘB signaling, which provided new targets for RA therapy." 2 Circular RNA circFIRRE drives osteosarcoma progression and metastasis through tumorigenic-angiogenic coupling. - hsa_circ_FIRRE circFIRRE DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated "upregulated circFIRRE was induced by transcription factor YY1, and partially boosted the mRNA and protein level of LUZP1 by sponging miR-486-3p and miR-1225-5p." 1 CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA-protein ternary complex. - hsa_circ_ARID1A CircARID1A DOID:10534 stomach cancer gastric cancer RNA-seq up-regulated "circARID1A is involved in the function of IGF2BP3 and GC proliferation, and the circARID1A-IGF2BP3-SLC7A5 axis." 1 The novel biomarker circ_0020339 drives septic acute kidney injury by targeting miR-17-5p/IPMK axis. hsa_circ_0020339 - circ_0020339 DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, microarray" up-regulated circ_0020339 drives septic acute kidney injury by targeting miR-17-5p/IPMK axis. 1 Curcumin suppresses colorectal cancer development with epithelial-mesenchymal transition via modulating circular RNA HN1/miR-302a-3p/PIK3R3 axis. - hsa_circ_HN1 circHN1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Curcumin suppresses colorectal cancer development with epithelial-mesenchymal transition via modulating circular RNA HN1/miR-302a-3p/PIK3R3 axis. 1 "Upregulation of hsa_circ_0004812 promotes COVID-19 cytokine storm via hsa-miR-1287-5p/IL6R, RIG-I axis." hsa_circ_0004812 hsa_circ_NINL circ_0004812 DOID:0080600 COVID-19 COVID-19 infection RT-qPCR up-regulated "Upregulation of hsa_circ_0004812 promotes COVID-19 cytokine storm via hsa-miR-1287-5p/IL6R, RIG-I axis." 1 Circular RNA MELK Promotes Chondrocyte Apoptosis and Inhibits Autophagy in Osteoarthritis by Regulating MYD88/NF-kappaB Signaling Axis through MicroRNA-497-5p. - hsa_circ_MELK circMELK DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated CircMELK promotes chondrocyte apoptosis and inhibits autophagy in OA by regulating MYD88/NF-kappaB signaling axis through miR-497-5p. 1 Study on the Mechanism of circRNA-0024103 Reducing Endothelial Cell Injury by Regulating miR-363/MMP-10. hsa_circ_0024103 - circRNA-0024103 DOID:1936 atherosclerosis atherosclerosis RT-qPCR dysregulated "circRNA-0024103 regulates the biological behaviors of endothelial cells such as proliferation, apoptosis, migration, and invasion through the miR-363/MMP-10 axis." 1 Oncogenic circular RNA circ_0007534 contributes to paclitaxel resistance in endometrial cancer by sponging miR-625 and promoting ZEB2 expression. hsa_circ_0007534 - circ_0007534 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated circ_0007534 plays a crucial role in EMT and paclitaxel resistance through miR-625/ZEB2 signaling. 1 CircSCAPER knockdown attenuates IL-1beta-induced chondrocyte injury by miR-127-5p/TLR4 axis in osteoarthritis. - hsa_circ_SCAPER CircSCAPER DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "CircSCAPER silencing protected against IL-1beta-induced apoptosis, ECM degradation, inflammation and oxidative stress in chondrocytes via miR-127-5p/TLR4 axis." 1 Potentials of circSOBP in the diagnosis and prognosis of gastric cancer. - hsa_circ_SOBP circSOBP DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Decreased circSOBP accumulation may be applied in clinical practice to improve the diagnosis and prognosis of GC. 1 Circular RNA circENTPD7 suppresses the accumulation of PTEN to promote cell proliferation in non-small cell lung cancer. - hsa_circ_ENTPD7 circENTPD7 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated overexpression of circENTPD7 promoted the proliferation of NSCLC cells and reduced the inhibitory effects of overexpression of PTEN on cell proliferation. 1 Silencing circ_0074371 inhibits the progression of sepsis-induced acute kidney injury by regulating miR-330-5p/ELK1 axis. hsa_circ_0074371 - circ_0074371 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated "Knockdown of circ_0074371 ameliorated LPS-induced HK2 cells apoptosis, inflammation and oxidative stress via regulating miR-330-5p/ELK1, opening a new window into the pathogenesis AKI." 1 Circ_0001982 Up-regulates the Expression of E2F1 by Adsorbing miR-1205 to Facilitate the Progression of Glioma. hsa_circ_0001982 - Circ_0001982 DOID:0060108 brain glioma glioma RT-qPCR up-regulated Circ_0001982 accelerates glioma progression by modulating the miR-1205/E2F1 axis. 1 Construction of circRNA-associated ceRNA network reveals the regulation of fibroblast proliferation in cervical cancer. - hsa_circ_ZNF208 circZNF208 DOID:4362 cervical cancer cervical cancer RNA-seq up-regulated "A novel circRNA: circZNF208 that can interfere with fibroblast proliferation in cervical cancer through a ceRNA regulatory network, thereby promoting fibroblast proliferation in cervical cancer and affecting the prognosis of cancer patients." 1 Circular RNA circWWC3 augments breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4. - hsa_circ_WWC3 circWWC3 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circWWC3 might augment breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4. 2 Reduced CircSMOC1 Level Promotes Metabolic Reprogramming via PTBP1 (Polypyrimidine Tract-Binding Protein) and miR-329-3p in Pulmonary Arterial Hypertension Rats. - rno_circ_SMOC1 CircSMOC1 DOID:14557 primary pulmonary hypertension pulmonary arterial hypertension "RT-qPCR, RNA-seq" down-regulated circSMOC1 is crucially involved in the metabolic reprogramming of pulmonary artery smooth muscle cells through PTBP1 and miR-329-3p to regulate pulmonary vascular remodeling in pulmonary arterial hypertension. 1 Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis. - - circRNA_008646 DOID:850 lung disease lung injury induced by FA RT-qPCR up-regulated "formaldehyde may induce lung injury, and this may be caused by up-regulatedrno_circRNA_008646, which medicated rno-miR-224/FOXI1/CFTR axis." 1 Circ_0007624 suppresses the development of esophageal squamous cell carcinoma via targeting miR-224-5p/CPEB3 to inactivate the EGFR/PI3K/AKT signaling. hsa_circ_0007624 - Circ_0007624 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR down-regulated circ_0007624/miR-224-5p/CPEB3 suppresses ESCC progression by inactivating EGFR/PI3K/AKT signaling. 1 Circ_0008717 Sponges miR-326 to Elevate GATA6 Expression to Promote Breast Cancer Tumorigenicity. hsa_circ_0008717 - Circ_0008717 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0008717 promoted breast cancer growth and metastasis through miR-326/GATA6 axis. 2 Circ_HIPK3 Inhibits H(2)O(2)-Induced Lens Epithelial Cell Injury in Age-Related Cataract Depending on the Regulation of miR-495-3p/HDAC4 Pathway. - hsa_circ_HIPK3 Circ_HIPK3 DOID:0070353 cataract age-related cataract RT-qPCR down-regulated circ_HIPK3 suppressed H(2)O(2)-induced lens epithelial cell injury by regulating miR-495-3p/HDAC4 axis. 3 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. - - mmu-Nfkb1_0001 DOID:114 heart disease cardiac hypertrophy and cardiac fibrosis RNA-seq dysregulated "8 circRNAs (mmu-Nfkb1_0001, mmu-Smad4_0007, mmu-Hecw2_0009, mmu-Itgbl1_0002, mmu-Lrrc2_0005, mmu-Cpeb3_0007, mmu-Ryr2_0040, and mmu-Rtn4_0001) involved in cardiac hypertrophy and cardiac fibrosis were identified." 1 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. - - mmu-Smad4_0007 DOID:114 heart disease cardiac hypertrophy and cardiac fibrosis RNA-seq dysregulated "8 circRNAs (mmu-Nfkb1_0001, mmu-Smad4_0007, mmu-Hecw2_0009, mmu-Itgbl1_0002, mmu-Lrrc2_0005, mmu-Cpeb3_0007, mmu-Ryr2_0040, and mmu-Rtn4_0001) involved in cardiac hypertrophy and cardiac fibrosis were identified." 1 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. - - mmu-Hecw2_0009 DOID:114 heart disease cardiac hypertrophy and cardiac fibrosis RNA-seq dysregulated "8 circRNAs (mmu-Nfkb1_0001, mmu-Smad4_0007, mmu-Hecw2_0009, mmu-Itgbl1_0002, mmu-Lrrc2_0005, mmu-Cpeb3_0007, mmu-Ryr2_0040, and mmu-Rtn4_0001) involved in cardiac hypertrophy and cardiac fibrosis were identified." 1 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. - - mmu-Itgbl1_0002 DOID:114 heart disease cardiac hypertrophy and cardiac fibrosis RNA-seq dysregulated "8 circRNAs (mmu-Nfkb1_0001, mmu-Smad4_0007, mmu-Hecw2_0009, mmu-Itgbl1_0002, mmu-Lrrc2_0005, mmu-Cpeb3_0007, mmu-Ryr2_0040, and mmu-Rtn4_0001) involved in cardiac hypertrophy and cardiac fibrosis were identified." 1 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. - - mmu-Lrrc2_0005 DOID:114 heart disease cardiac hypertrophy and cardiac fibrosis RNA-seq dysregulated "8 circRNAs (mmu-Nfkb1_0001, mmu-Smad4_0007, mmu-Hecw2_0009, mmu-Itgbl1_0002, mmu-Lrrc2_0005, mmu-Cpeb3_0007, mmu-Ryr2_0040, and mmu-Rtn4_0001) involved in cardiac hypertrophy and cardiac fibrosis were identified." 1 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. - - mmu-Cpeb3_0007 DOID:114 heart disease cardiac hypertrophy and cardiac fibrosis RNA-seq dysregulated "8 circRNAs (mmu-Nfkb1_0001, mmu-Smad4_0007, mmu-Hecw2_0009, mmu-Itgbl1_0002, mmu-Lrrc2_0005, mmu-Cpeb3_0007, mmu-Ryr2_0040, and mmu-Rtn4_0001) involved in cardiac hypertrophy and cardiac fibrosis were identified." 1 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. - - mmu-Ryr2_0040 DOID:114 heart disease cardiac hypertrophy and cardiac fibrosis RNA-seq dysregulated "8 circRNAs (mmu-Nfkb1_0001, mmu-Smad4_0007, mmu-Hecw2_0009, mmu-Itgbl1_0002, mmu-Lrrc2_0005, mmu-Cpeb3_0007, mmu-Ryr2_0040, and mmu-Rtn4_0001) involved in cardiac hypertrophy and cardiac fibrosis were identified." 1 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. - - mmu-Rtn4_0001 DOID:114 heart disease cardiac hypertrophy and cardiac fibrosis RNA-seq dysregulated "8 circRNAs (mmu-Nfkb1_0001, mmu-Smad4_0007, mmu-Hecw2_0009, mmu-Itgbl1_0002, mmu-Lrrc2_0005, mmu-Cpeb3_0007, mmu-Ryr2_0040, and mmu-Rtn4_0001) involved in cardiac hypertrophy and cardiac fibrosis were identified." 1 Hsa_circ_0044907 promotes acute myeloid leukemia progression through upregulating oncogene KIT via sequestering miR-186-5p. hsa_circ_0044907 hsa_circ_RPS6KB1 circ_0044907 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "Circ_0044907 absorbed miR-186-5p to block the inhibiting impact of miR-186-5p on KIT, thus promoting AML progression." 1 Circ_0003489 facilitates multiple myeloma progression by targeting miR-433-3p/PBX3 axis. hsa_circ_0003489 - Circ_0003489 DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated Circ_0003489 facilitated MM progression by targeting miR-433-3p/PBX3 axis. 2 ciRS-7 Enhances the Progression of Hepatocellular Carcinoma through miR-944/NOX4 Pathway. - - ciRS-7 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "ciRS-7 enhanced the proliferation, migration, and invasion of HCC through miR-944/NOX4 pathway." 1 Circular RNA hsa_circ_0007367 promotes the progression of pancreatic ductal adenocarcinoma by sponging miR-6820-3p and upregulating YAP1 expression. hsa_circ_0007367 hsa_circ_UBAP2 - DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma microarray up-regulated hsa_circ_0007367 acts as an oncogene via modulating miR-6820-3p/YAP1 axis to promote the progression of PDAC. 1 "CircSOD2 Contributes to Tumor Progression, Immune Evasion and Anti-PD-1 Resistance in Hepatocellular Carcinoma by Targeting miR-497-5p/ANXA11 Axis." - hsa_circ_SOD2 CircSOD2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircSOD2 Contributes to Tumor Progression, Immune Evasion and Anti-PD-1 Resistance in Hepatocellular Carcinoma by Targeting miR-497-5p/ANXA11 Axis." 3 Circular Noncoding RNA hsa_circ_0003570 as a Prognostic Biomarker for Hepatocellular Carcinoma. hsa_circ_0003570 hsa_circ_FAM53B - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated Hsa_circ_0003570 is a potential prognostic biomarker in patients with HCC. 3 circCNN2 Accelerates Cell Proliferation and Invasion in Lung Squamous Cell Carcinoma via Regulating miR-184/E2F1 and Activating MAPK Signaling Pathway. - hsa_circ_CNN2 circCNN2 DOID:3907 lung squamous cell carcinoma lung squamous cell carcinoma RT-qPCR up-regulated circCNN2 activated MAPK signaling pathway through the miR-184/E2F1 axis to promote proliferation and invasion of LUSC cells. 1 CircRNA circ-PDCD11 is highly expressed in lung large-cell carcinoma and predicts poor survival. - hsa_circ_PDCD11 circ-PDCD11 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated CircRNA circ-PDCD11 is highly expressed specifically in LLCC and predicts poor survival. 1 Circ_0006789 Promotes the Progression of Hepatocellular Carcinoma Cells via Modulating miR-1324 and SOX12. hsa_circ_0006789 - Circ_0006789 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Circ_0006789 modulates the growth, migration and invasion of HCC cells by regulating miR-1324/SOX12 axis." 1 circHIPK2 Has a Potentially Important Clinical Significance in Colorectal Cancer Progression via HSP90 Ubiquitination by miR485-5p. - hsa_circ_HIPK2 circHIPK2 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "miR-485-5p, as the target of circHIPK2 in CRC model, played a role in promoting CRC progression and expediting HSP90 ubiquitination." 1 Circ_0042986 Presence Restrains Cervical Cancer Development via Upregulating PEG3 by Directly Targeting miR-582-3p. hsa_circ_0042986 - Circ_0042986 DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated "circ_0042986 overexpression decoyed miR-582-3p to increase PEG3 expression, thereby blocking the malignant progression of CC." 1 Circular RNA profile in Grave disease and potential function of hsa_circ_0090364. hsa_circ_0090364 hsa_circ_PHF16 - DOID:12361 Graves disease Graves disease "RT-qPCR, microarray" up-regulated hsa_circ_0090364 may regulate the JAK-STAT pathway via the hsa-miR-378a-3p/IL-6ST/IL21R axis to promote cell growth. 1 ALKBH5-mediated m6A modification of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription. - hsa_circ_CCDC134 circCCDC134 DOID:4362 cervical cancer cervical cancer "RT-qPCR, RNA-seq" up-regulated ALKBH5-mediated m6A modification of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription. 1 Circ_SNX27 regulates hepatocellular carcinoma development via miR-637/FGFR1 axis. - hsa_circ_SNX27 Circ_SNX27 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_SNX27 contributed to HCC development via miR-637/FGFR1 axis, offering a new idea for the treatment of HCC." 3 CircKIF4A promotes glioma growth and temozolomide resistance by accelerating glycolysis. - hsa_circ_KIF4A CircKIF4A DOID:0060108 brain glioma glioma RT-qPCR up-regulated the upregulation of circKIF4A facilitates glioma progression by means of binding miR-335-5p and upregulating ALDOA expression. 2 Circular RNA circESPL1 knockdown alleviates lipopolysaccharide (LPS)-induced lung cell injury via sponging miR-326 to regulate MAPK14. - hsa_circ_ESPL1 circESPL1 DOID:10533 viral pneumonia Infantile pneumonia RT-qPCR up-regulated CircESPL1 knockdown might attenuate LPS-caused lung cell injury by regulating the miR-326/ MAPK14 axis. 1 Bioinformatic analysis of circular RNA expression profiles in a rat lumbosacral spinal root avulsion model. - - circr_7025 DOID:0080001 bone disease lumbosacral spinal root avulsion RNA-seq down-regulated circRNA_7025 protected against oxygen-glucose deprivation induced neuronal apoptosis via the circRNA_7025/miR-1224/miR-326-5p axis. 1 circ_0041795 Induces YAP1 Upregulation to Accelerate the Progression of Diabetic Retinopathy through Binding to miR-589-5p. hsa_circ_0041795 - circ_0041795 DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR dysregulated circ_0041795 facilitated the development of DR by inducing miR-589-5p-mediated YAP1 upregulation. 2 "Hsa_circ_0087302, a circular RNA, affects the progression of osteosarcoma via the Wnt/beta-catenin signaling pathway." hsa_circ_0087302 hsa_circ_TLE4 circ_0087302 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" down-regulated hsa_circ_0087302 may provide a new direction for the diagnosis and treatment of osteosarcoma. 1 The Sponge Interaction Between Circular RNA and microRNA Serves as a Fast-Evolving Mechanism That Suppresses Non-small Cell Lung Cancer (NSCLC) in Humans. hsa_circ_0003497 hsa_circ_WDPCP - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated hsa_circ_0003497 suppresses NSCLC through miR-197-3p and CTNND1. 1 CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR. - hsa_circ_CREIT CircRNA-CREIT DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, RNA-seq" down-regulated CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR. 1 Circ_0001360 absence alleviates oxygen-glucose deprivation/reoxygenation-induced SK-N-SH cell injury via controlling the miR-671-5p/BMF pathway. hsa_circ_0001360 - Circ_0001360 DOID:6713 cerebrovascular disease ischaemic stroke RT-qPCR up-regulated Circ_0001360 contributed to OGD/R-caused SK-N-SH cell injury via targeting the miR-671-5p/BMF network and activating the NF-kappaB pathway. 2 Prediction of COPD acute exacerbation in response to air pollution using exosomal circRNA profile and Machine learning. hsa_circ_0005045 hsa_circ_RTN4 - DOID:3083 chronic obstructive pulmonary disease chronic obstructive pulmonary disease RT-qPCR up-regulated "hsa_circ_0005045 is upregulated by PM(2.5) and binds to the protein cargo peroxiredoxin2, which functionally aggravates hallmarks of COPD by recruiting neutrophil elastase and triggering in situ release of tumor necrosis factor (TNF)-alpha by inflammatory cells." 1 CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling. - hsa_circ_SMARCC1 CircSMARCC1 DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" up-regulated "CircSMARCC1 up-regulates the chemokine CCL20 secretion by sponging miR-1322, which is involved in the crosstalk between tumor cells and TAMs by targeting CCL20/CCR6 signaling to promote progression of PCa." 1 Circ_0039908/miR-let-7c/RRM2 axis was identified played an important role in lung adenocarcinoma by integrated analysis. hsa_circ_0039908 - Circ_0039908 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR dysregulated "Circ_0039908/miR-let-7c/RRM2 axis can promote the ability of proliferation, migration and invasion of LUAD cells." 2 Hsa_circ_0001204 modulates inflammatory response of macrophages infected by Mycobacterium tuberculosis via TLR4/NF-kappaB signalling pathway. hsa_circ_0001204 - - DOID:399 tuberculosis tuberculosis RT-qPCR down-regulated "Hsa_circ_0001204 confers protective effects in M.tb-infected THP-1 cells, at least partly via the inhibition of TLR4/NF-¦ĘB signalling pathway." 3 Circular RNA circMET contributes to tamoxifen resistance of breast cancer cells by targeting miR-204/AHR signaling. - hsa_circ_MET circMET DOID:1612 breast cancer breast cancer RT-qPCR dysregulated circular RNA circMET contributed to tamoxifen resistance of breast cancer cells by targeting miR-204-5p/AHR signaling. 1 Comprehensive circular RNA expression profile of lung adenocarcinoma with bone metastasis: Identification of potential biomarkers. hsa_circ_0096442 - circ_0096442 DOID:3910 lung adenocarcinoma lung adenocarcinoma "RT-qPCR, RNA-seq" dysregulated circ_0096442 was found to promote the growth and metastasis of LUAD in a bone microenvironment. 1 Circular RNA KIF4A Promotes Liver Metastasis of Breast Cancer by Reprogramming Glucose Metabolism. - hsa_circ_KIF4A circKIF4A DOID:1612 breast cancer breast cancer RT-qPCR up-regulated the circKIF4A-miR-335-OCT4/ALDOA-HK2/PKM2 axis is critical to breast cancer metabolic reprogramming. 4 Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell injury via miR-335-5p/HIPK1 axis. - hsa_circ_ZNF644 circ-ZNF644 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated "Circ-ZNF644 knockdown relieved LPS-induced HK2 cell injury through the miR-335-5p/HIPK1 axis, confirming that circ-ZNF644 contributed to sepsis-induced AKI." 2 CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer. hsa_circ_0028899 hsa_circ_RNF10 Circ_RNF10 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated circ_RNF10 suppressed BC malignant behavior by targeting miR-942-5p/GOLIM4 axis. 3 Circ_0061140 Contributes to Ovarian Cancer Progression by Targeting miR-761/LETM1 Signaling. hsa_circ_0061140 - Circ_0061140 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated Circ_0061140 aggravated ovarian cancer progression through miR-761-dependent regulation of LETM1. 3 "Circ_0002476 regulates cell growth, invasion, and mtDNA damage in non-small cell lung cancer by targeting miR-1182/TFAM axis." hsa_circ_0002476 - Circ_0002476 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0002476 regulates cell growth, invasion, and mtDNA damage in non-small cell lung cancer by targeting miR-1182/TFAM axis." 1 Circ_0091822 aggravates ox-LDL-induced endothelial cell injury through targeting the miR-661/RAB22A axis. hsa_circ_0091822 - Circ_0091822 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Circ_0091822 contributed to cell injury by targeting miR-661/RAB22A axis in ox-LDL-stimulated HUVECs. 1 Circ_0027446 induces CLDN1 expression to promote papillary thyroid cancer cell malignancy by binding to miR-129-5p. hsa_circ_0027446 - Circ_0027446 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "Circ_0027446 contributed to PTC cell tumor properties by regulating the miR-129-5p/CLDN1 pathway, showing circ_0027446 might be a therapeutic target in PTC." 1 Oxidant stress-sensitive circRNA Mdc1 controls cardiomyocyte chromosome stability and cell cycle re-entry during heart regeneration. - mmu_circ_Mdc1 circMdc1 DOID:5844 myocardial infarction myocardial Infarction "RT-qPCR, microarray" dysregulated Oxidative stress-sensitive circMdc1 plays an important role in cardiac regeneration and heart repair after injury by regulating DNA damage and chromosome stability in cardiomyocytes by blocking the translation of the host gene Mdc1. 1 "circCRKL, a circRNA derived from CRKL, regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation." - hsa_circ_CRKL circCRKL DOID:8552 chronic myeloid leukemia chronic myeloid leukemia RT-qPCR up-regulated circCRKL is specifically expressed and regulates BCR-ABL expression level via decoying miR-877-5p in BCR-ABL(+) cells. 1 Radiated glioblastoma cell-derived exosomal circ_0012381 induce M2 polarization of microglia to promote the growth of glioblastoma by CCL2/CCR2 axis. hsa_circ_0012381 - circ_0012381 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" up-regulated Radiated glioblastoma cell-derived exosomal circ_0012381 induce M2 polarization of microglia to promote the growth of glioblastoma by CCL2/CCR2 axis. 1 The potential of mecciRNA in hepatic stellate cell to regulate progression of nonalcoholic hepatitis. hsa_circ_0089761 hsa_circ_None - DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" dysregulated hsa_circ_0089761 and hsa_circ_0089763 could function as competing for endogenous RNAs (ceRNAs) to regulate fibrosis-related signals. 2 The potential of mecciRNA in hepatic stellate cell to regulate progression of nonalcoholic hepatitis. hsa_circ_0089763 hsa_circ_None - DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis "RT-qPCR, microarray" dysregulated hsa_circ_0089761 and hsa_circ_0089763 could function as competing for endogenous RNAs (ceRNAs) to regulate fibrosis-related signals. 2 Comprehensive analysis of m(6)A circRNAs identified in colorectal cancer by MeRIP sequencing. hsa_circ_0032821 hsa_circ_CEP128 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "(has_circ_0032821, has_circ_0019079, has_circ_0093688) were upregulated and circRNAs (hsa_circ_0026782, hsa_circ_0108457) were downregulated in CRC." 1 Comprehensive analysis of m(6)A circRNAs identified in colorectal cancer by MeRIP sequencing. hsa_circ_0019079 hsa_circ_KIF20B - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "(has_circ_0032821, has_circ_0019079, has_circ_0093688) were upregulated and circRNAs (hsa_circ_0026782, hsa_circ_0108457) were downregulated in CRC." 1 Comprehensive analysis of m(6)A circRNAs identified in colorectal cancer by MeRIP sequencing. hsa_circ_0093688 hsa_circ_AKR1E2 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "(has_circ_0032821, has_circ_0019079, has_circ_0093688) were upregulated and circRNAs (hsa_circ_0026782, hsa_circ_0108457) were downregulated in CRC." 1 Comprehensive analysis of m(6)A circRNAs identified in colorectal cancer by MeRIP sequencing. hsa_circ_0026782 hsa_circ_ITGA7 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "(has_circ_0032821, has_circ_0019079, has_circ_0093688) were upregulated and circRNAs (hsa_circ_0026782, hsa_circ_0108457) were downregulated in CRC." 4 Comprehensive analysis of m(6)A circRNAs identified in colorectal cancer by MeRIP sequencing. hsa_circ_0108457 hsa_circ_SETBP1 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "(has_circ_0032821, has_circ_0019079, has_circ_0093688) were upregulated and circRNAs (hsa_circ_0026782, hsa_circ_0108457) were downregulated in CRC." 1 CircLMTK2 Silencing Attenuates Gemcitabine Resistance in Pancreatic Cancer by Sponging miR-485-5p and to Target PAK1. - hsa_circ_LMTK2 CircLMTK2 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated circLMTK2 knockdown attenuated GEM-resistant PC cells by regulating PAK1 via miR-485-5p. 1 CircEPSTI1 Promotes the Proliferation of HER2-Positive Breast Cancer Cells via circEPSTI1/miR-145/ERBB3 Axis. - hsa_circ_EPSTI1 CircEPSTI1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "circEPSTI1, an overexpressed circRNA in HER2-positive breast cancer, promotes the proliferation, migration, and invasion of SKBR3 and BT474 cells through the miR-145/ERBB3 axis." 1 Circ_000829 Plays an Anticancer Role in Renal Cell Carcinoma by Suppressing SRSF1-Mediated Alternative Splicing of SLC39A14. - - Circ_000829 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR down-regulated Circ_000829 Plays an Anticancer Role in Renal Cell Carcinoma by Suppressing SRSF1-Mediated Alternative Splicing of SLC39A14. 1 "Hsa_circRNA_0008028 Deficiency Ameliorates High Glucose-Induced Proliferation, Calcification, and Autophagy of Vascular Smooth Muscle Cells via miR-182-5p/TRIB3 Axis." hsa_circ_0008028 - circRNA_0008028 DOID:9351 diabetes mellitus vascular complications of diabetes RT-qPCR up-regulated "hsa_circRNA_0008028 can act as a sponge of miR-182-5p and promote HG-induced proliferation, calcification, and autophagy of VSMCs partly by regulating TRIB3." 1 CircTUBD1 Regulates Radiation-induced Liver Fibrosis Response via a circTUBD1/micro-203a-3p/Smad3 Positive Feedback Loop. - hsa_circ_TUBD1 CircTUBD1 DOID:409 liver disease radiation-induced liver fibrosis RNA-seq dysregulated CircTUBD1 Regulates Radiation-induced Liver Fibrosis Response via a circTUBD1/micro-203a-3p/Smad3 Positive Feedback Loop. 2 CircDUSP22 Overexpression Restrains Pancreatic Cancer Development via Modulating miR-1178-3p and Downstream BNIP3. - hsa_circ_DUSP22 CircDUSP22 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR down-regulated CircDUSP22 upregulation blocked PaCa development partly by targeting miR-1178-3p and increasing BNIP3. 1 circ_0061265 competitively binds to microRNA-885-3p to promote the development of gastric cancer by upregulating AURKA expression. hsa_circ_0061265 - circ_0061265 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circ_0061265 may increase AURKA expression by competitively binding to miRNA-885-3p, thereby promoting GC development." 1 CircRIC8B regulates the lipid metabolism of chronic lymphocytic leukemia through miR199b-5p/LPL axis. - hsa_circ_RIC8B CircRIC8B DOID:1040 chronic lymphocytic leukemia chronic lymphocytic leukemia "RT-qPCR, RNA-seq" up-regulated circRIC8B regulates the lipid metabolism abnormalities in and development of CLL through the miR-199b-5p/LPL axis. 1 "A Novel circRNA hsa_circRNA_002178 as a Diagnostic Marker in Hepatocellular Carcinoma Enhances Cell Proliferation, Invasion, and Tumor Growth by Stabilizing SRSF1 Expression." hsa_circ_002178 - hsa_circRNA_002178 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated hsa_circRNA_002178 overexpression encouraged the stability of SRSF1 mRNA expression. 1 circ_0052184 Promotes Colorectal Cancer Progression via Targeting miR-604/HOXA9 Axis. hsa_circ_0052184 - circ_0052184 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circ_0052184 promoted the occurrence and development of colorectal cancer by targeting the miR-604/HOXA9 axis. 2 Hsa_circ_0000877 facilitates the progression of diffuse large B-cell lymphoma by miR-370-3p/mitogen-activated protein kinase kinase kinase kinase 4/Hippo pathway. hsa_circ_0000877 hsa_circ_MIR4746 circ_0000877 DOID:0050745 diffuse large B-cell lymphoma diffuse large b-cell lymphoma RT-qPCR up-regulated circ_0000877 could regulate the malignant evolution of DLBCL by miR-370-3p/MAP4K4/Hippo pathway. 1 Circular RNA circ_0007841 participates in progression of nonsmall cell lung cancer via miR-199a-5p/SphK2 axis. hsa_circ_0007841 - circ_0007841 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ_0007841 had a positive influence in improving NSCLC development by targeting miR-199a-5p and upregulating oncogene SphK2. 2 "CircRNA High Mobility Group At-hook 2 regulates cell proliferation, metastasis and glycolytic metabolism of nonsmall cell lung cancer by targeting miR-331-3p to upregulate High Mobility Group At-hook 2." - hsa_circ_HMGA2 circHMGA2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircRNA High Mobility Group At-hook 2 regulates cell proliferation, metastasis and glycolytic metabolism of nonsmall cell lung cancer by targeting miR-331-3p to upregulate High Mobility Group At-hook 2." 1 circRNA mannosidase alpha class 1A member 2 contributes to the proliferation and motility of papillary thyroid cancer cells through upregulating metadherin via absorbing microRNA-449a. - hsa_circ_MAN1A2 CircMAN1A2 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated CircMAN1A2 contributed to the proliferation ability and motility of PTC cells through enhancing MTDH expression via sponging miR-449a. 1 Circ_0000467 modulates malignant characteristics of colorectal cancer via sponging miR-651-5p and up-regulating DNMT3B. hsa_circ_0000467 - Circ_0000467 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0000467 may enhance the growth and metastasis of CRC cells by targeting miR-651-5p and up-regulating DNMT3B expression. 4 Hsa_circ_0003221 facilitates the malignant development of bladder cancer cells via resulting in the upregulation of DHCR24 by targeting miR-892b. hsa_circ_0003221 hsa_circ_PTK2 circ_0003221 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "circ_0003221 targeted miR-892b to elevate the DHCR24 level, thus accelerating cell development and glycolytic metabolism of BLCA cells." 4 Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1. - hsa_circ_PDK1 circPDK1 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated circPDK1 was activated by HIF1A at the transcriptional level by modulating the miR-628-3p/BPTF axis and degrading BIN1. 1 CircPRKCH modulates extracellular matrix formation and metabolism by regulating the miR-145/HGF axis in osteoarthritis. - hsa_circ_PRKCH CircPRKCH DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated circPRKCH promoted chondrocyte apoptosis and ECM degradation via the miR-145/HGF axis in OA. 3 Hsa_circ_0000098 is a novel therapeutic target that promotes hepatocellular carcinoma development and resistance to doxorubicin. hsa_circ_0000098 hsa_circ_SLC30A7 circ_0000098 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ_0000098 is an oncogenic circRNA that promotes HCC development through the miR-383/MCUR1 axis. 4 circRNA PLOD2 promotes tumorigenesis and Warburg effect in colon cancer by the miR-513a-5p/SIX1/LDHA axis. - hsa_circ_PLOD2 circPLOD2 DOID:219 colon cancer colon cancer RT-qPCR up-regulated circPLOD2 promoted colon cancer progression through miR-513a-5p/SIX1/LDHA axis. 1 CircMAP3K4 protects human lens epithelial cells from H(2)O(2)-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract. - hsa_circ_MAP3K4 CircMAP3K4 DOID:0070353 cataract age-related cataract RT-qPCR down-regulated circMAP3K4 protected SRA01/04 cells from H(2)O(2)-induced dysfunction in ARC through mediating miR-193a-3p/PLCD3 axis. 1 Circ TYMP1 Inhibits Carcinogenesis and Cisplatin Resistance in Ovarian Cancer by Reducing Smad2/3 Phosphorylation via a MicroRNA-182A-3p/TGF1B Axis. - hsa_circ_TYMP1 Circ TYMP1 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "TYMP1 sequesters miR-182A-3p and promotes TGF1B in ovarian carcinoma, boosting carcinogenesis and cisplatin resistance." 1 circFOXO3 Induced by KLF16 Modulates Clear Cell Renal Cell Carcinoma Growth and Natural Killer Cell Cytotoxic Activity through Sponging miR-29a-3p and miR-122-5p. - hsa_circ_FOXO3 circFOXO3 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated circFOXO3 Induced by KLF16 Modulates Clear Cell Renal Cell Carcinoma Growth and Natural Killer Cell Cytotoxic Activity through Sponging miR-29a-3p and miR-122-5p. 1 "Circ_0123996 promotes the proliferation, inflammation, and fibrosis of mesangial cells by sponging miR-203a-3p to upregulate SOX6 in diabetic nephropathy." hsa_circ_0123996 - Circ_0123996 DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "circ_0123996 promoted the proliferation, inflammation, and fibrosis of mesangial cells via modulating the miR-203a-3p/SOX6 axis." 1 Circ-TRIO promotes TNBC progression by regulating the miR-432-5p/CCDC58 axis. - hsa_circ_TRIO Circ-TRIO DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, RNA-seq" up-regulated Circ-TRIO promotes TNBC progression by regulating the miR-432-5p/CCDC58 axis. 1 Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization. - mmu_circ_Snhg11 circ-Snhg11 DOID:9351 diabetes mellitus diabetes "RT-qPCR, RNA-seq" down-regulated These findings suggest that circ-Snhg11 promotes HIF-1alpha expression through miR-144_3p sponging. Our data demonstrate that circ-Snhg11 overexpression exosome from ADSCs suppresses HG-induced endothelial cell damage and induces M2-like macrophage polarization via the miR-144_3p/HIF-1alpha axis. 2 "Hsa_circ_0044301 Regulates Gastric Cancer Cell Proliferation, Migration, and Invasion by Modulating the Hsa-miR-188-5p/DAXX Axis and MAPK Pathway." hsa_circ_0044301 hsa_circ_KPNB1 circ_0044301 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Hsa_circ_0044301 Regulates Gastric Cancer Cells Proliferation, Migration, and Invasion by Modulating the Hsa-miR-188-5p/DAXX Axis and MAPK Pathway." 1 Exploratory Circular RNA Profiling in Adrenocortical Tumors. - hsa_circ_PHC3 circPHC3 DOID:3948 adrenocortical carcinoma adrenocortical tumors "RT-qPCR, RNA-seq" up-regulated "circPHC3 could be confirmed to be significantly overexpressed in ACC, ACA vs. NAC samples by RT-qPCR." 1 Potential biomarkers for retinopathy of prematurity identified by circular RNA profiling in peripheral blood mononuclear cells. - - hsa_circRNA_061346 DOID:13025 retinopathy of prematurity retinopathy of prematurity "RT-qPCR, RNA-seq" dysregulated "Three circRNAs (hsa_circRNA_061346, hsa_circRNA_092369, and hsa_circRNA_103554) were identified as potential diagnostic biomarkers for ROP with certain clinical values." 1 Potential biomarkers for retinopathy of prematurity identified by circular RNA profiling in peripheral blood mononuclear cells. - - hsa_circRNA_092369 DOID:13025 retinopathy of prematurity retinopathy of prematurity "RT-qPCR, RNA-seq" dysregulated "Three circRNAs (hsa_circRNA_061346, hsa_circRNA_092369, and hsa_circRNA_103554) were identified as potential diagnostic biomarkers for ROP with certain clinical values." 1 Potential biomarkers for retinopathy of prematurity identified by circular RNA profiling in peripheral blood mononuclear cells. - - hsa_circRNA_103554 DOID:13025 retinopathy of prematurity retinopathy of prematurity "RT-qPCR, RNA-seq" dysregulated "Three circRNAs (hsa_circRNA_061346, hsa_circRNA_092369, and hsa_circRNA_103554) were identified as potential diagnostic biomarkers for ROP with certain clinical values." 1 "Hsa_circ_0000479/Hsa-miR-149-5p/RIG-I, IL-6 Axis: A Potential Novel Pathway to Regulate Immune Response against COVID-19." hsa_circ_0000479 - - DOID:0080600 COVID-19 COVID-19 RT-qPCR up-regulated "Upregulation of hsa_circ_0000479, RIG-I, and IL-6, and downregulation of hsa-miR-149-5p, along with correlation studies, indicate that hsa_circ_0000479/hsa-miR-149-5p/RIG-I, IL-6 axis could play a role in regulating the immune response against SARS-CoV-2. However, more studies are needed in this area." 1 Circular RNA 0010117 promotes aggressive glioblastoma behavior by regulating the miRNA-6779-5p/SPEN axis. hsa_circ_0010117 - circ-0010117 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated circular RNA 0010117 promotes the aggressive behavior of glioblastoma by regulating the miRNA-6779-5p/SPEN axis. 1 PLGA-microspheres-carried circGMCL1 protects against Crohn colitis through alleviating NLRP3 inflammasome-induced pyroptosis by promoting autophagy. - hsa_circ_GMCL1 circGMCL1 DOID:8778 Crohn disease Crohn disease "RT-qPCR, microarray" down-regulated circGMCL1 protects intestinal barrier function against Crohns colitis through alleviating NLRP3 inflammasome-mediated epithelial pyroptosis by promoting autophagy through regulating ANXA7 via sponging miR-124-3p. 1 STAM binding protein regulated by hsa_circ_0007334 exerts oncogenic potential in pancreatic cancer. hsa_circ_0007334 hsa_circ_MBOAT2 circ_0007334 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated STAMBP depended on its deubiquitinase activities to induce the malignant behaviors of PC cells and was involved in the regulatory mechanism of hsa_circ_0007334 on PC cell mobility. 2 Circ_0007099 upregulates GNG7 to function as a tumor inhibitor in gastric carcinoma by interacting with miR-425-3p. hsa_circ_0007099 - Circ_0007099 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "circ_0007099 inhibits the malignant behavior of GC cells by binding to miR-425-3p, thus regulating the expression of GNG7." 2 CircMMP9 accelerates the progression of hepatocellular carcinoma through the miR-149/CCND2 axis. - hsa_circ_MMP9 CircMMP9 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circMMP9 exacerbated HCC progression through the miR-149/CCND2 axis. 1 Circular RNA ZFR promotes cell cycle arrest and apoptosis of colorectal cancer cells via the miR-147a/CACUL1 axis. - hsa_circ_ZFR CircZFR DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Knockdown of the expression of circZFR upregulated miR-147a expression and reduced CACUL1 expression levels, thereby inhibiting the proliferation of CC cells and inducing cell cycle arrest and apoptosis." 2 Knockdown of Circ_0037658 Alleviates IL-1beta-Induced Osteoarthritis Progression by Serving as a Sponge of miR-665 to Regulate ADAMTS5. hsa_circ_0037658 - Circ_0037658 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Circ_0037658 knockdown relieved IL-1beta-triggered chondrocyte injury via regulating the miR-665/ADAMTS5 axis. 2 CircNFIX knockdown inhibited AML tumorigenicity by the miR-876-3p/TRIM31 axis. - hsa_circ_NFIX CircNFIX DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated CircNFIX knockdown could suppress the proliferation and induce the apoptosis of AML cells by targeting the miR-876-3p/TRIM31 axis. 2 CircPTPRM accelerates malignancy of papillary thyroid cancer via miR-885-5p/DNMT3A axis. - hsa_circ_PTPRM CircPTPRM DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated circPTPRM may play an oncogenic role in PTC through circPTPRM/miR-885-5p/DNMT3A axis. 1 Circ_0040929 Serves as Promising Biomarker and Potential Target for Chronic Obstructive Pulmonary Disease. hsa_circ_0040929 - Circ_0040929 DOID:3083 chronic obstructive pulmonary disease chronic obstructive pulmonary disease RT-qPCR up-regulated Circ_0040929 played a promoting role in CSE-induced COPD by regulating miR-515-5p/IGFBP3 axis. 1 Circular RNA Circ_0001777 Suppresses Lung Adenocarcinoma Progression In Vitro and In Vivo. hsa_circ_0001777 - circ_0001777 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated Circ_0001777 suppressed the progression of lung adenocarcinoma by binding to miR-942-5p to induce PRICKLE2 expression. 1 Circular RNA circPGD contributes to gastric cancer progression via the sponging miR-16-5p/ABL2 axis and encodes a novel PGD-219aa protein. - hsa_circ_PGD circPGD DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circPGD contributes to gastric cancer progression via the sponging miR-16-5p/ABL2 axis and encodes a novel PGD-219aa protein. 1 CircLIFR Inhibits Non-small Cell Lung Cancer Progression by Acting as a miR-429 Sponge to Enhance CELF2 Expression. - hsa_circ_LIFR CircLIFR DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated Overexpression of circLIFR could suppress NSCLC progress by acting as a sponge of miR-429 to regulate the expression of CELF2 and PTEN/AKT-signaling pathways in NSCLC. 3 circS100A11 enhances M2a macrophage activation and lung inflammation in children with asthma. - hsa_circ_S100A11 circS100A11 DOID:0080815 childhood-onset asthma childhood asthma "RT-qPCR, microarray" up-regulated circS100A11 and S100A11 promote M2a macrophage activation and lung inflammation in asthma model and may serve as potential therapeutic and diagnostic targets in children with asthma. 1 Circular RNA circ-CD44 regulates chemotherapy resistance by targeting the miR-330-5p/ABCC1 axis in colorectal cancer cells. - hsa_circ_CD44 circ-CD44 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circ-CD44 functioned as a miRNA sponge for miR-330-5p to upregulate the expression of ABCC1 and regulate chemotherapy resistance in CRC cells. 1 circANKRD17(has_circ_0007883) confers paclitaxel resistance of ovarian cancer via interacting with FUS to stabilize FOXR2. hsa_circ_0007883 hsa_circ_ANKRD17 circANKRD17 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated circANKRD17(has_circ_0007883) confers paclitaxel resistance of ovarian cancer via interacting with FUS to stabilize FOXR2. 2 Hsa_circ_0000437 promotes pathogenesis of gastric cancer and lymph node metastasis. hsa_circ_0000437 hsa_circ_CORO1C circ_0000437 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Hsa_circ_0000437 promotes pathogenesis of gastric cancer and lymph node metastasis. 2 Circ_0136666 aggravates osteosarcoma development through mediating miR-1244/CEP55 axis. hsa_circ_0136666 - Circ_0136666 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circ_0136666 aggravates osteosarcoma development through mediating miR-1244/CEP55 axis. 2 "Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway." - hsa_circ_CSNK1G1 Circ-CSNK1G1 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during TNBC development by regulating the miR-28-5p/LDHA pathway." 1 A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway. - hsa_circ_ZNF609 circ-ZNF609 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated highly expressed circ-ZNF609-encoded ZNF609-250aa induces cell apoptosis and AKI by impairing the autophagy flux via an AKT/mTOR-dependent mechanism. 1 CircRNA_0050486 promotes cell apoptosis and inflammation by targeting miR-1270 in atherosclerosis. hsa_circ_0050486 - CircRNA_0050486 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated circ_0050486 knockdown inhibited inflammation and apoptosis by targeting miR-1270 in oxLDL-induced THP-1 macrophages. 1 Systematic identification of aberrant non-coding RNAs and their mediated modules in rotator cuff tears. hsa_circ_0000722 - hsa_circ_0000722 DOID:381 arthropathy Rotator cuff tears RNA-seq dysregulated "hsa_circ_0000722, hsa-miR-129-5p and hsa-miR-30c-5p, whose interacting mRNAs related to muscle diseases, fat and inflammation." 1 The role of circular RNA hsa_circ_0001789 as a diagnostic biomarker in gastric carcinoma. hsa_circ_0001789 hsa_circ_RAB11FIP1 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Hsa_circ_0001789 may be a novel biomarker for the diagnosis of gastric carcinoma. 2 Hsa_circ_0008301 as a potential biomarker of disease activity for primary Sjogren syndrome: Increased expression in peripheral blood of patients with primary Sjogren syndrome. hsa_circ_0008301 hsa_circ_TOLLIP circ_0008301 DOID:12894 Sjogren syndrome primary Sjogren syndrome RT-qPCR up-regulated "Hsa_circ_0008301 is expressed in higher levels in the peripheral blood of patients with pSS, which is related to the disease activity." 1 Magnetically responsive nanoplatform targeting circRNA circ_0058051 inhibits hepatocellular carcinoma progression. hsa_circ_0058051 - circ_0058051 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated PPPCSs/si-circ_0058051 complex may provide a novel and promising method of HCC treatment. 1 A circular RNA derived from GLIS3 accelerates the proliferation of glioblastoma cells through competitively binding with miR-449c-5p to upregulate CAPG and GLIS3. - hsa_circ_GLIS3 circGLIS3 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated circGLIS3 could promote proliferation and inhibit apoptosis of GBM cells via targeting miR-449c-5p/GLIS3/CAPG axis in vitro. 1 CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation. - hsa_circ_SEMA4B CircSEMA4B DOID:1612 breast cancer breast cancer RT-qPCR down-regulated CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation. 1 Microarray profiling identifies hsa_circ_0082003 as a novel tumor promoter for papillary thyroid carcinoma. hsa_circ_0082003 hsa_circ_MET circ_0082003 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, microarray" up-regulated Hsa_circ_0082003 may serve as a novel diagnostic biomarker and potential therapeutic target for PTC. 1 Peripheral Blood circRNA Microarray Profiling Identities hsa_circ_0001831 and hsa_circ_0000867 as Two Novel circRNA Biomarkers for Early Type 2 Diabetic Nephropathy. hsa_circ_0001831 hsa_circ_SCRIB - DOID:557 kidney disease diabetic nephropathy "RT-qPCR, microarray" up-regulated hsa_circ_0001831 and hsa_circ_0000867 can be used as novel diagnostic biomarkers for ET2DN. 1 Peripheral Blood circRNA Microarray Profiling Identities hsa_circ_0001831 and hsa_circ_0000867 as Two Novel circRNA Biomarkers for Early Type 2 Diabetic Nephropathy. hsa_circ_0000867 hsa_circ_OAZ1 - DOID:557 kidney disease diabetic nephropathy "RT-qPCR, microarray" up-regulated hsa_circ_0001831 and hsa_circ_0000867 can be used as novel diagnostic biomarkers for ET2DN. 1 CircRNA CircEHBP1 Regulates the Maturation of MiR-129 to Increase the Chemoresistance of Cancer Cells to Adriamycin in Acute Myeloid Leukaemia. - hsa_circ_EHBP1 circEHBP1 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated CircEHBP1 may suppress miR-129 maturation to increase the chemoresistance of cancer cells to ADR in AML. 1 Circ_0031242 regulates the functional properties of hepatocellular carcinoma cells through the miR-944/MAD2L1 axis. hsa_circ_0031242 - Circ_0031242 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ_0031242 regulated tumor cell progression and tumor growth through the miR-944/MAD2L1 axis in HCC. 3 N6-methyladenosine modification of circ_0003215 suppresses the pentose phosphate pathway and malignancy of colorectal cancer through the miR-663b/DLG4/G6PD axis. hsa_circ_0003215 - circ_0003215 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq, microarray" dysregulated m6A-modified circ_0003215 as a novel regulator of metabolic glucose reprogramming that inhibited the PPP and the malignant phenotype of CRC via the miR-663b/DLG4/G6PD axis. 1 m(6)A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis. hsa_circ_0000816 hsa_circ_FOXK2 circFOXK2 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma microarray up-regulated "m(6)A-modified circFOXK2 in OSCC through the m(6)A-dependent IGF2BP3/GLUT1 axis, indicating a potential therapeutic target for OSCC." 1 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/beta_catenin pathway." hsa_circ_0026652 - circ_0026652 DOID:9538 multiple myeloma multiple myeloma "RT-qPCR, microarray" dysregulated circ_0026652 knockdown enhanced chemosensitivity to bortezomib through the microRNA (miR)_608_mediated Wnt/beta_catenin pathway in U266 and RPIM_8226 cells. 1 CircPAK1 promotes the progression of hepatocellular carcinoma via modulation of YAP nucleus localization by interacting with 14-3-3zeta. - hsa_circ_PAK1 CircPAK1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircPAK1 exerts its oncogenic function by competitively binding 14-3-3 zeta with YAP, thus promoting YAP nucleus localization, leading to the inactivation of a Hippo signaling pathway." 1 Circular RNA circ_SKA3 enhances gastric cancer development by targeting miR-520h. - hsa_circ_SKA3 circ_SKA3 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circ_SKA3 enhances gastric cancer development by targeting miR-520h. 3 The Down-Regulation of Circ_0059707 in Acute Myeloid Leukemia Promotes Cell Growth and Inhibits Apoptosis by Regulating miR-1287-5p. hsa_circ_0059707 - Circ_0059707 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR down-regulated circ_0059707 inhibited cell growth and promoted apoptosis by up-regulating miR-1287-5p. 1 Circ-OMAC drives metastasis in oral squamous cell carcinoma. - hsa_circ_OMAC Circ-OMAC DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RNA-seq up-regulated Circ-OMAC as an oncogene is a potential therapeutic target and prognostic marker in oral cancer. 1 Exosomal circRNA Scm-like with four malignant brain tumor domains 2 (circ-SFMBT2) enhances the docetaxel resistance of prostate cancer via the microRNA-136-5p/tribbles homolog 1 pathway. - hsa_circ_SFMBT2 circ-SFMBT2 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated Exosomal circSFMBT2 enhanced the DTX resistance of PCa by miR-136-5p/TRIB1 axis. 1 Circ_0039569 contributes to the paclitaxel resistance of endometrial cancer via targeting miR-1271-5p/PHF6 pathway. hsa_circ_0039569 - Circ_0039569 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated circ_0039569 might contribute to the PTX resistance of EC through the regulation of the miR-1271-5p/PHF6 axis. 3 Circ_0005615 contributes to the progression and Bortezomib resistance of multiple myeloma by sponging miR-185-5p and upregulating IRF4. hsa_circ_0005615 - Circ_0005615 DOID:9538 multiple myeloma multiple myeloma RT-qPCR up-regulated Circ_0005615 contributed to the malignant progression and bortezomib resistance of multiple myeloma through mediating miR-185-5p/IRF4 signaling. 2 Circ_0002111 modulates the growth process of papillary thyroid carcinoma cells by targeting the miR-363-3p/HMGB1 axis. hsa_circ_0002111 - Circ_0002111 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated silencing circ_0002111 constrained the progression of PTC by the miR-363-3p/HMGB1 axis. 4 circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p. hsa_circ_0086296 - circ_0086296 DOID:1936 atherosclerosis atherosclerosis "RT-qPCR, RNA-seq" up-regulated This study sought to provide a deep understanding of the mechanisms underlying the aberrant EC phenotype in AS. 1 Transcriptome Sequencing Reveal That Rno-Rsf1_0012 Participates in Levodopa-Induced Dyskinesia in Parkinson Disease Rats via Binding to Rno-mir-298-5p. - - rno-Rsf1_0012 DOID:14330 Parkinson disease Parkinson disease RNA-seq up-regulated The expression of rno-Rsf1_0012 was significantly increased in the striatum of LID rats and competitively bound rno-mir-298-5p. 1 Circular RNA hsa_circ_0062682 Binds to YBX1 and Promotes Oncogenesis in Hepatocellular Carcinoma. hsa_circ_0062682 hsa_circ_TPST2 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq up-regulated hsa_circ_0062682 Binds to YBX1 and Promotes Oncogenesis in Hepatocellular Carcinoma. 1 Circular RNA circDOCK1 contributes to osteosarcoma progression by acting as a ceRNA for miR-936 to regulate LEF1. - hsa_circ_DOCK1 circDOCK1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated CircDOCK1 knockdown might attenuate OS cell malignant biological behaviors by regulating the miR-936/GFRA1 axis. 4 Hsa_circ_0003602 Contributes to the Progression of Colorectal Cancer by Mediating the miR-149-5p/SLC38A1 Axis. hsa_circ_0003602 hsa_circ_SMARCC1 circ_0003602 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0003602 knockdown impedes CRC development by targeting the miR-149-5p/SLC38A1 axis. 1 "Exosome-delivered circSATB2 targets the miR-330-5p/PEAK1 axis to regulate proliferation, migration and invasion of lung cancer cells." - hsa_circ_SATB2 circSATB2 DOID:1324 lung cancer lung cancer RT-qPCR dysregulated exosomal transfer of circSATB2 contributed to the malignant development of lung cancer by acting as a sponge of miR-330-5p to upregulate PEAK1. 2 CircRNA_33702 Promotes Renal Fibrosis by Targeting the miR-29b-3p/WNT1-Inducible Signaling Pathway Protein 1 Pathway. - - CircRNA_33702 DOID:0050855 renal fibrosis renal fibrosis RT-qPCR up-regulated CircRNA_33702 Promotes Renal Fibrosis by Targeting the miR-29b-3p/WNT1-Inducible Signaling Pathway Protein 1 Pathway. 1 Circ_0051079 functions as an oncogenic regulator in osteosarcoma by leading to MAFB expression upregulation by competitively interacting with miR-1286. hsa_circ_0051079 - Circ_0051079 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "circ_0051079 contributed to OS progression via miR-1286-mediated upregulation of MAFB, confirming the interaction of circ_0051079/miR-1286/MAFB axis in OS." 3 "Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma." hsa_circ_0001438 hsa_circ_LARP1B - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated hsa_circ_0001438 and hsa_circ_0000417 might be potential biomarkers for the specific diagnosis of HCC. 2 "Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma." hsa_circ_0000417 hsa_circ_CPSF6 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated hsa_circ_0001438 and hsa_circ_0000417 might be potential biomarkers for the specific diagnosis of HCC. 2 Circ_0005050 promotes the proliferation of oral squamous cell carcinoma and inhibits the apoptosis by activating JAK/STAT3 signaling pathway. hsa_circ_0005050 - Circ_0005050 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "circ_0005050 regulates miR-23a-3p/miR-625-5p/STAT3 axis to activate JAK/STAT3 signaling pathway, consequently facilitating OSCC cell proliferation and inhibiting cell apoptosis." 2 CircPTK2 accelerates tumorigenesis of colorectal cancer by upregulating AKT2 expression via miR-506-3p. - hsa_circ_PTK2 CircPTK2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "The circPTK2/miR-506-3p/AKT2 axis plays a novel and essential role in promoting CRC progression, providing potential targets for CRC therapeutic modality." 4 Circular RNA circSFMBT2 downregulation by HBx promotes hepatocellular carcinoma metastasis via the miR-665/TIMP3 axis. - hsa_circ_SFMBT2 circSFMBT2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" down-regulated Circular RNA circSFMBT2 downregulation by HBx promotes hepatocellular carcinoma metastasis via the miR-665/TIMP3 axis. 1 The pivotal regulatory factor circBRWD1 inhibits arsenic exposure-induced lung cancer occurrence by binding mRNA and regulating its stability. - hsa_circ_BRWD1 circBRWD1 DOID:1324 lung cancer lung cancer RT-qPCR down-regulated circBRWD1 inhibits arsenic exposure-induced lung cancer occurrence by binding mRNA and regulating its stability. 1 Effect of circPUM1 on radioresistance of cervical cancer cells through targeting miR-144-3p. - hsa_circ_PUM1 circPUM1 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Silencing circPUM1 may inhibit the proliferation, colony formation, migration, invasion and induce apoptosis of cervical cancer cells through targeting and regulating the expression of miR-144-3p." 1 Hsa_circ_0002082 up-regulates Centromere Protein F via abolishing miR-508-3p to promote breast cancer progression. hsa_circ_0002082 hsa_circ_MALAT1 circ_0002082 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Knockdown of hsa_circ_0002082 suppresses breast cancer growth and metastasis by miR-508-3p/CENPF axis,." 1 Circular RNA circPRMT5 is upregulated in breast cancer and is required for cell proliferation and migration. - hsa_circ_PRMT5 circPRMT5 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circPRMT5 is upregulated in breast cancer and is required for cell proliferation and migration. 2 CircRNA SCMH1 regulates the miR-200a-3p/ZEB1 signaling axis to promote diabetes-induced retinal epithelial-mesenchymal transition. - hsa_circ_SCMH1 circSCMH1 DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR up-regulated CircRNA SCMH1 regulates the miR-200a-3p/ZEB1 signaling axis to promote diabetes-induced retinal epithelial-mesenchymal transition. 1 CircMERTK modulates the suppressive capacity of tumor-associated macrophage via targeting IL-10 in colorectal cancer. - hsa_circ_MERTK CircMERTK DOID:9256 colorectal cancer colorectal cancer RNA-seq up-regulated TAM-like cell could exert immunosuppressive activity via circMERTK/miR-125a-3p/IL-10 axi. 1 circZC3HAV1 Regulates TBC1D9 to Affect the Biological Behavior of Colorectal Cancer Cells. hsa_circ_0082628 hsa_circ_ZC3HAV1 circ_0082628 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "circZC3HAV1 could upregulate TBC1D9 via absorbing miR-146b-3p, consequently inhibiting migratory and invasive capabilities of CRC cells." 1 [CircRNA circTNPO1 promotes the proliferation and metastasis of osteosarcoma by sponging miR-338-3p]. - hsa_circ_TNPO1 circTNPO1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "CircTNPO1 promotes the proliferation and metastasis of OS by sponging miR-338-3p, which could be a new target for OS treatments." 1 Circular RNA hsa_circ_0018189 drives non-small cell lung cancer growth by sequestering miR-656-3p and enhancing xCT expression. hsa_circ_0018189 hsa_circ_CUL2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Hsa_circ_0018189 drove NSCLC growth by interacting with miR-656-3p and upregulating xCT. 2 Circular RNA expression profile of systemic lupus erythematosus and its clinical significance as a potential novel biomarker. hsa_circ_0006689 hsa_circ_SLC15A4 - DOID:9074 systemic lupus erythematosus systemic lupus erythematosus "RT-qPCR, RNA-seq" up-regulated hsa_circ_0006689 may be a useful circRNA biomarker for SLE diagnosis and prognosis. 1 Circular RNA hsa_circ_0000915 promotes propranolol resistance of hemangioma stem cells in infantile haemangiomas. hsa_circ_0000915 hsa_circ_FKBP8 - DOID:255 hemangioma infantile hemangioma RT-qPCR up-regulated "the activation of IL-6/STAT3/Circ_0000915/miR-890/RNF187 axis in propranolol resistance of IH, and provide therapeutic implications for patients of IH with propranolol resistance." 1 Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer. - hsa_circ_CEA Circ_CEA DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "circ_CEA protects GC cells from stress-induced apoptosis, via acting as a protein scaffold and interacting with p53 and CDK1 proteins." 1 CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in epilepsy. - hsa_circ_SRRM4 circSRRM4 DOID:1826 epilepsy epilepsy RT-qPCR up-regulated CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in epilepsy. 1 Circ_0072995 drives cervical cancer development by regulating the miR-29a/WDR5 axis. hsa_circ_0072995 - Circ_0072995 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Circ_0072995 drives cervical cancer development by regulating the miR-29a/WDR5 axis. 1 CircZNF367 suppresses osteogenic differentiation of human bone marrow mesenchymal stromal/stem cells via reducing HuR-mediated mRNA stability of LRP5. hsa_circ_0008842 - CircZNF367 DOID:11476 osteoporosis osteoporosis RNA-seq up-regulated circZNF367 played a role in osteogenic differentiation of hBMSCs via reducing HuR-mediated mRNA stability of LRP5. 1 Circ_0001535 Facilitates Tumor Malignant Progression by miR-485-5p/LASP1 Axis in Colorectal Cancer. hsa_circ_0001535 - Circ_0001535 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0001535 promotes colorectal cancer cell development by absorbing miR-485-5p and upregulating LASP1. 2 Downregulation of circLIFR exerts cancer-promoting effects on hepatocellular carcinoma in vitro. - hsa_circ_LIFR circLIFR DOID:684 hepatocellular carcinoma hepatocellular carcinoma RNA-seq down-regulated "the downregulation of circLIFR in HCC has a can-cer-promoting effect by interacting with TBK1 to promote the activation of downstream NF-kappaB pathway genes related to cell proliferation, migration, and invasion." 2 The circCDK17/miR-122-5p/ASF1B axis regulates the progression of cervical cancer. hsa_circ_0002762 hsa_circ_CDK17 circCDK17 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circCDK17 regulates the expression of ASF1B by miR-122-5p competition and thus promotes the development of CC. 4 Knockdown circTRIM28 enhances tamoxifen sensitivity via the miR-409-3p/HMGA2 axis in breast cancer. - hsa_circ_TRIM28 circTRIM28 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Knockdown circTRIM28 enhances tamoxifen sensitivity via the miR-409-3p/HMGA2 axis in breast cancer. 1 Hsa_hsa_circ_0081069 promotes the progression of colorectal cancer through sponging miR-665 and regulating E2F3 expression. hsa_circ_0081069 hsa_circ_COL1A2 circ_0081069 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Hsa_hsa_circ_0081069 promotes the progression of colorectal cancer through sponging miR-665 and regulating E2F3 expression. 2 "CircHOMER1 aggravates oxidative stress, inflammation and extracellular matrix deposition in high glucose-induced human mesangial cells." - hsa_circ_HOMER1 CircHOMER1 DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "CircHOMER1 promoted HG-induced HMCs oxidative stress, inflammation and ECM accumulation via the miR-137/SOX6 axis, suggesting that circHOMER1 might be a target for DN treatment." 1 Circ-CTNNB1 drives aerobic glycolysis and osteosarcoma progression via m6A modification through interacting with RBM15. - hsa_circ_CTNNB1 Circ-CTNNB1 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated Circ-CTNNB1 drives aerobic glycolysis and OS progression by facilitating RBM15-mediated m6A modification. 1 Hsa_circ_0081069 facilitates tongue squamous cell carcinoma progression by modulating MAP2K4 expression via miR-634. hsa_circ_0081069 hsa_circ_COL1A2 circ_0081069 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma RT-qPCR up-regulated "Circ_0081069 is involved in the regulation of proliferation, cycle progress, migration, and invasion of TSCC cells through the miR-634/MAP2K4 axis ." 1 Role of circular RNA cdr1as in modulation of macrophage phenotype. - hsa_circ_Cdr1as circ-Cdr1as DOID:0050117 disease by infectious agent tissue inflammation microarray dysregulated circ-Cdr1as was one of the most downregulated in pro-inflammatory macrophages and significantly upregulated in anti-inflammatory macrophages in vitro 1 CircRAPGEF5 interacts with RBFOX2 to confer ferroptosis resistance by modulating alternative splicing of TFRC in endometrial cancer. - hsa_circ_RAPGEF5 CircRAPGEF5 DOID:1380 endometrial cancer endometrial cancer "RT-qPCR, RNA-seq" up-regulated CircRAPGEF5 interacts with RBFOX2 to confer ferroptosis resistance by modulating alternative splicing of TFRC in endometrial cancer. 1 CircFNDC3B knockdown restrains the progression of oesophageal squamous cell carcinoma through miR-214-3p/CDC25A axis. - hsa_circ_FNDC3B CircFNDC3B DOID:7051 esophageal basaloid squamous cell carcinoma oesophageal squamous cell carcinoma RT-qPCR up-regulated CircFNDC3B silencing restrains the tumorigenesis of oesophageal squamous cell carcinoma through miR-214-3p/CDC25A axis. 1 Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR-384. - hsa_circ_PVT1 circPVT1 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR-384. 1 Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634. hsa_circ_0110634 - circ-0110634 DOID:7147 ankylosing spondylitis ankylosing spondylitis RT-qPCR up-regulated triptolide targets circ-0110634 to regulate osteoclastogenesis. 1 Overexpression of hsa_circ_0006470 inhibits the malignant behavior of gastric cancer cells via regulation of miR-1234/TP53I11 axis. hsa_circ_0006470 hsa_circ_MFN2 circ_0006470 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated OE of hsa_circ_0006470 notably inhibited the tumorigenesis of GC by regulating the miR-1234/TP53I11 axis. 5 CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR-375/SLC7A11 axis. - hsa_circ_RPPH1 CircRPPH1 DOID:10534 stomach cancer gastric cancer RT-qPCR dysregulated CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR-375/SLC7A11 axis. 2 Circ_0008726 promotes malignant progression of ESCC cells through miR-206/HOXA13 pathway. hsa_circ_0008726 - Circ_0008726 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "circ_0008726 exerted the carcinogenic effects to regulate the proliferation, invasion, angiogenesis and apoptosis of ESCC cells by targeting miR-206/HOXA13 axis." 1 Hsa_circ_0007478 aggravates NLRP3 inflammasome activation and lipid metabolism imbalance in ox-LDL-stimulated macrophage via miR-765/EFNA3 axis. hsa_circ_0007478 hsa_circ_TM7SF3 circ_0007478 DOID:1936 atherosclerosis atherosclerotic plaque microarray up-regulated hsa_circ_0007478/miR-765/EFNA3 axis could also be involved in the inhibition of the lipid metabolism and foam cells formation in ox-LDL-macrophages. 2 Circ_0000808 promotes the development of non-small cell lung cancer by regulating glutamine metabolism via the miR-1827/SLC1A5 axis. hsa_circ_0000808 - Circ_0000808 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ_0000808 enhanced the progression of NSCLC by promoting glutamine metabolism through the miR-1827/SLC1A5 axis. 1 Circ_0000189 Promotes the Malignancy of Glioma Cells via Regulating miR-192-5p-ZEB2 Axis. hsa_circ_0000189 - Circ_0000189 DOID:0060108 brain glioma glioma RT-qPCR up-regulated circ_0000189 facilitates the progression of glioma by modulating miR-192-5p/ZEB2 axis. 1 hsa_circ_0003176 Suppresses the Progression of Non-Small-Cell Lung Cancer via Regulating miR-182-5p/RBM5 Axis. hsa_circ_0003176 hsa_circ_TBX5 circ_0003176 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated hsa_circ_0003176 suppressed the NSCLC progression via regulating miR-182-5p/RBM5 axis. 1 Transcription factor Nrf2 binds to circRNAPIBF1 to regulate SOD2 in lung adenocarcinoma progression. - hsa_circ_RNAPIBF1 circRNAPIBF1 DOID:3910 lung adenocarcinoma lung adenocarcinoma microarray up-regulated circPIBF1 in pyroptosis-related LUAD carcinogenesis and implicate a role of Nrf2/EP300/SOD2 signaling in this process. 1 "Circ-EIF3I facilitates proliferation, migration, and invasion of lung cancer via regulating the activity of Wnt/beta-catenin pathway through the miR-1253/NOVA2 axis." - hsa_circ_EIF3I Circ-EIF3I DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "Circ-EIF3I might function as an oncogene in LC, which promoted LC progression by the miR-1253/NOVA2/Wnt/beta-catenin network." 1 CircTADA2A up-regulates MAPK8 by targeting MiR-214-3p and recruiting EIF4A3 to promote the invasion and migration of non-small cell lung cancer cells. - hsa_circ_TADA2A CircTADA2A DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircTADA2A enhances MAPK8 expression by serving as a miR-214-3p sponge and EIF4A3 decoy, consequently promoting invasion and migration of NSCLC cells." 6 "Circ_0022383 alleviates IL-1beta-induced apoptosis, inflammation and extracellular matrix degeneration in osteoarthritis cell model by miR-3619-5p/SIRT1 axis." hsa_circ_0022383 - Circ_0022383 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "Circ_0022383 protected chondrocytes from IL-1beta-induced apoptosis, inflammation and ECM degeneration by miR-3619-5p/SIRT1 axis." 1 Downregulation of Circ_0088196 Contributes to the Development of Trophoblastic Cells through miR-133b Sponging Function to Affect the AHNAK Expression. hsa_circ_0088196 - Circ_0088196 DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated "circ_0088196 knockdown facilitated trophoblastic cell development by regulating the levels of miR-133b and AHNAK, suggesting that circ_0088196 promoted the PE progression via the miR-133b/AHNAK axis." 2 Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the beta-TrCP/c-Myc/SRSF1 positive feedback loop. - hsa_circ_PVT1 circPVT1 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the beta-TrCP/c-Myc/SRSF1 positive feedback loop. 1 Upregulation of circ_0008812 and circ_0001583 predicts poor prognosis and promotes breast cancer proliferation. hsa_circ_0008812 - circ_0008812 DOID:1612 breast cancer breast cancer microarray up-regulated Upregulation of circ_0008812 and circ_0001583 predicts poor prognosis and promotes breast cancer proliferation. 1 Upregulation of circ_0008812 and circ_0001583 predicts poor prognosis and promotes breast cancer proliferation. hsa_circ_0001583 - circ_0001583 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated Upregulation of circ_0008812 and circ_0001583 predicts poor prognosis and promotes breast cancer proliferation. 2 CircNf1-mediated CXCL12 expression in the spinal cord contributes to morphine analgesic tolerance. - rno_circ_Nf1 CircNf1 DOID:2560 morphine dependence morphine analgesic tolerance RNA-seq dysregulated circNf1 functions as a sponge for miR-330-3p and miR-665 and induces the upregulation of CXCL12 at both transcriptional and translational levels in morphine-treated rats. 1 Circ-CCS enhances autophagy during imatinib resistance of gastrointestinal stromal tumor by regulating miR-197-3p/ATG10 signaling. hsa_circ_0092306 hsa_circ_CCS Circ-CCS DOID:9253 gastrointestinal stromal tumor gastrointestinal stromal tumour RT-qPCR up-regulated "By modulating the miR-197-3p/ATG10 axis, circ-CCS increased imatinib resistance in GIST cells, establishing a potential target for reversing medication resistance in such patients." 1 Knockdown of circ-ADAM9 inhibits malignant phenotype and enhances radiosensitivity in breast cancer cells via acting as a sponge for miR-383-5p. - hsa_circ_ADAM9 circ-ADAM9 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ-ADAM9 was found to participate in breast cancer progression through targeting the miR-383-5p/PFN2 axis. 3 Blocking circ_0010235 suppresses acquired paclitaxel resistance of non-small cell lung cancer by sponging miR-512-5p to modulate FAM83F expression. hsa_circ_0010235 - circ_0010235 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Blocking circ_0010235 suppresses acquired paclitaxel resistance of non-small cell lung cancer by sponging miR-512-5p to modulate FAM83F expression. 4 "Exosomal circPRRX1 functions as a ceRNA for miR-596 to promote the proliferation, migration, invasion, and reduce radiation sensitivity of gastric cancer cells via the upregulation of NF-kappaB activating protein." - hsa_circ_PRRX1 circPRRX1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Exosomal circPRRX1 functions as a ceRNA for miR-596 to promote the proliferation, migration, invasion, and reduce radiation sensitivity of gastric cancer cells via the upregulation of NF-kappaB activating protein." 2 Exosome-mediated transfer of circ_0063526 enhances cisplatin resistance in gastric cancer cells via regulating miR-449a/SHMT2 axis. hsa_circ_0063526 - circ_0063526 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Exosomal circ_0063526 facilitated CDDP resistance in gastric cancer via regulating the miR-449a/SHMT2 axis. 1 Circular RNA circ-AGFG1 contributes to esophageal squamous cell carcinoma progression and glutamine catabolism by targeting microRNA-497-5p/solute carrier family 1 member 5 axis. - hsa_circ_AGFG1 circ-AGFG1 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated circ-AGFG1 acted as an oncogene to elevate the malignant potential and promote the glutamine catabolism of ESCC cells by targeting the miR-497-5p/SLC1A5 axis. 1 circUBAP2 inhibits cisplatin resistance in gastric cancer via miR-300/KAT6B axis. - hsa_circ_UBAP2 circUBAP2 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated the circUBAP2/miR-300/KAT6B axis was involved in the inhibition of CDDP resistance in GC. 2 Knockdown of circHIPK3 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells through activating the autophagy flux. - hsa_circ_HIPK3 circHIPK3 DOID:12347 osteogenesis imperfecta osteogenesis RT-qPCR dysregulated Knockdown of circHIPK3 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells through activating the autophagy flux. 1 Hsa_circ_0001535 Regulates Colorectal Cancer Progression via the miR-433-3p/RBPJ Axis. hsa_circ_0001535 hsa_circ_FAM13B circ_0001535 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "The circ_0001535/miR-433-3p/ RBPJ axis plays a catalytic role in the progression of CRC, which may provide new insights into the molecular mechanism of CRC." 2 Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1. - hsa_circ_ZNF451 circZNF451 DOID:3910 lung adenocarcinoma lung adenocarcinoma "RT-qPCR, RNA-seq" up-regulated Exosomal circZNF451 reshapes the tumor immune microenvironment by inducing macrophages polarization via the FXR1- ELF4-IRF4 axis and is a novel biomarker for predicting the sensitivity of PD1 blockade in LUAD. 1 CircRNF144B/miR-342-3p/FBXL11 axis reduced autophagy and promoted the progression of ovarian cancer by increasing the ubiquitination of Beclin-1. - hsa_circ_RNF144B CircRNF144B DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, RNA-seq" up-regulated "CircRNF144B increased FBXL11 level by sponging miR-342-3p, whereas elevated FBXL11 promoted the ubiquitination and protein degradation of Beclin-1, thus suppressing autophagy flux and promoting OC progression." 1 Circ-WDR27 regulates mycobacterial vitality and secretion of inflammatory cytokines in Mycobacterium tuberculosis-infected macrophages via the miR-370-3p/FSTL1 signal network. - hsa_circ_WDR27 Circ-WDR27 DOID:399 tuberculosis tuberculosis RT-qPCR down-regulated circ-WDR27 repressed M.tb vitality and stimulated pro-inflammatory cytokines in M.tb-infected macrophages by affecting the miR-370-3p/FSTL1 axis. 1 Circ_HECW2 regulates ox-LDL-induced dysfunction of cardiovascular endothelial cells by miR-942-5p/TLR4 axis. - hsa_circ_HECW2 Circ_HECW2 DOID:3393 coronary artery disease coronary artery disease RT-qPCR up-regulated Circ_HECW2 could regulate ox-LDL-induced cardiovascular endothelial cell dysfunction through targeting miR-942-5p/TLR4 axis. 2 hsa_circ_0000264 promotes tumor progression via the hsa-let-7b-5p/HMGA2 axis in head and neck squamous cell carcinoma. hsa_circ_0000264 hsa_circ_CHST15 circ_0000264 DOID:5520 head and neck squamous cell carcinoma head and neck squamous cell carcinoma RNA-seq up-regulated "hsa_circ_0000264 promotes HNSCC progression via the hsa-let-7b-5p/HMGA2 axis, and hsa_circ_0000264 can serve as a potential target for HNSCC treatment." 1 Knockdown of circ_0038467 alleviates lipopolysaccharides-induced 16HBE cell injury by regulating the miR-545-3p/TRAF1 axis in neonatal pneumonia. hsa_circ_0038467 - circ_0038467 DOID:10533 viral pneumonia Neonatal pneumonia RT-qPCR up-regulated Circ_0038467 knockdown mitigated LPS-exposed 16HBE cell damage through regulating miR-545-3p/PPARA axis. 1 Circular RNA circRASSF5 Functions as an Anti-Oncogenic Factor in Hepatocellular Carcinoma by Acting as a Competitive Endogenous RNA Through Sponging miR-331-3p. - hsa_circ_RASSF5 circRASSF5 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated circRASSF5 Functions as an Anti-Oncogenic Factor in Hepatocellular Carcinoma by Acting as a Competitive Endogenous RNA Through Sponging miR-331-3p. 1 CircMAT2B facilitates the progression of head and neck squamous cell carcinoma via sponging miR-491-5p to trigger ASCT2-mediated glutaminolysis. - hsa_circ_MAT2B CircMAT2B DOID:5520 head and neck squamous cell carcinoma head and neck squamous cell carcinoma RT-qPCR up-regulated "circMAT2B could modulate the processes of cell proliferation, migration, invasion, and glutaminolysis of HNSCC cells partly via the miR-491-5p/ASCT2 axis." 1 Circ_0082182 upregulates the NFIB level via sponging miR-326 to promote oxaliplatin resistance and malignant progression of colorectal cancer cells. hsa_circ_0082182 - Circ_0082182 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circ_0082182 elevated the NFIB expression to regulate OXA resistance and CRC progression by absorbing miR-326. 2 circRERE regulates the expression of GBX2 through miR-1299 and ZC3H13/N(6)-methyladenosine (m(6)A) to promote growth and invasion of hepatocellular carcinoma cells. - hsa_circ_RERE circRERE DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circRERE promotes the growth and invasion of HCC cells by regulating the expression of GBX2 through miR-1299 and ZC3H13/m(6)A, indicating that it is a key circRNA in the progression of HCC." 1 Silencing circ_0000644 inhibits papillary thyroid cancer cell malignancy by combining with miR-671-5p to release the inhibition on ANXA2. hsa_circ_0000644 - circ_0000644 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated Circ_0000644 depletion repressed PTC cell tumor properties through the miR-671-5p/ANXA2 axis. 1 The FUS/circEZH2/KLF5/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition. - hsa_circ_EZH2 circEZH2 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated The FUS/circEZH2/KLF5/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition. 1 Two circPPFIA1s negatively regulate liver metastasis of colon cancer via miR-155-5p/CDX1 and HuR/RAB36. - hsa_circ_PPFIA1s circPPFIA1s DOID:219 colon cancer colon cancer "RT-qPCR, microarray" down-regulated circPPFIA1s inhibit the liver metastasis of CRC via the miR-155-5p/CDX1 and HuR/RAB36 pathways. 1 Circular RNA hsa_circ_0003574 as a biomarker for prediction and diagnosis of ischemic stroke caused by intracranial atherosclerotic stenosis. hsa_circ_0003574 hsa_circ_C20orf11 - DOID:1936 atherosclerosis Intracranial atherosclerotic stenosis RT-qPCR up-regulated sa_circ_0003574 as a biomarker for prediction and diagnosis of ischemic stroke caused by intracranial atherosclerotic stenosis. 1 circTOP2A functions as a ceRNA to promote glioma progression by upregulating RPN2. - hsa_circ_TOP2A circTOP2A DOID:0060108 brain glioma glioma microarray up-regulated circTOP2A functions as a ceRNA to promote glioma progression by upregulating RPN2. 2 Circ_0002111/miR-134-5p/FSTL1 signal axis regulates tumor progression and glycolytic metabolism in papillary thyroid carcinoma cells. hsa_circ_0002111 - Circ_0002111 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated circ_0002111 promoted the malignant behaviors of PTC cells partly by regulating the miR-134-5p/FSTL1 molecular network. 4 "Circ_0060967 facilitates proliferation, migration, and invasion of non-small-cell lung cancer cells by sponging miR-660-3p/UBN2." hsa_circ_0060967 - Circ_0060967 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0060967 facilitated NSCLC progression by enhancing UBN2 expression via sponging miR-660-3p. 1 CircKIF4A Is a Prognostic Factor and Modulator of Natural Killer/T-Cell Lymphoma Progression. - hsa_circ_KIF4A CircKIF4A DOID:50743 mature T-cell and NK-cell lymphoma natural killer/T-cell lymphoma RT-qPCR up-regulated circKIF4A is oncogenic in NKTL and that it is a predictor of poor prognosis of NKTL. 1 circSMAD4 Promotes Experimental Colitis and Impairs Intestinal Barrier Functions by Targeting Janus Kinase 2 Through Sponging miR-135a-5p. - hsa_circ_SMAD4 circSMAD4 DOID:8778 Crohn disease Crohn disease "RT-qPCR, microarray" up-regulated circSMAD4 regulates the progression of experimental colitis via the miR-135a-5p/JAK2 signalling axis . 1 Hsa_circ_0000851 promotes PDK1/p-AKT-mediated cell proliferation and migration by regulating miR-1183 in triple-negative breast cancer. hsa_circ_0000851 hsa_circ_TCF4 circ_0000851 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "hsa_circ_0000851 bound directly to miR-1183, accelerating the expression of its target gene PDK1, which facilities BC cell proliferation and migration through PDK1/p-AKT." 1 Circ_0003570 Suppresses the progression of hepatocellular carcinoma through miR-182-5p/STARD13 regulatory axis. hsa_circ_0003570 - Circ_0003570 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR dysregulated circ_0003570 suppresses the development of HCC by modulating miR-182-5p/STARD13 axis. 3 Circular RNA circ_0008365 regulates SOX9 by targeting miR-338-3p to inhibit IL-1beta-induced chondrocyte apoptosis and extracellular matrix degradation. hsa_circ_0008365 - circ_0008365 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "Circ_0008365 alleviates IL-1beta-induced CHON-001 cell damage through the miR-338-3p/SOX9 axis, which suggested that circ_0008365 might be a new therapeutic target for OA." 2 Circular RNA hsa_circ_0000144 aggravates ovarian Cancer progression by regulating ELK3 via sponging miR-610. hsa_circ_0000144 hsa_circ_SLAMF6 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated circ_0000144 could enhance the carcinogenesis of ovarian cancer by specifically targeting miR-610. 1 Self-restricted circular RNA circSOX2 suppressed the malignant progression in SOX2-amplified LUSC. - hsa_circ_SOX2 CircSOX2 DOID:3907 lung squamous cell carcinoma Lung squamous cell carcinoma RT-qPCR down-regulated Self-restricted circular RNA circSOX2 suppressed the malignant progression in SOX2-amplified LUSC. 1 Ligustrazine exerts neuroprotective effects via circ_0008146/miR-709/Cx3cr1 axis to inhibit cell apoptosis and inflammation after cerebral ischemia/reperfusion injury. - - circ_0008146 DOID:2316 brain ischemia cerebral ischemia/reperfusion injury RNA-seq up-regulated Ligustrazine exerts neuroprotective effects via circ_0008146/miR-709/Cx3cr1 axis to inhibit cell apoptosis and inflammation after cerebral ischemia/reperfusion injury. 1 CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation. - hsa_circ_FKBP5 circFKBP5 DOID:11121 pulpitis pulpitis RT-qPCR down-regulated "CircFKBP5 could protect against LPS-induced apoptosis, inflammation, and osteogenic differentiation inhibition in hDPSCs via the miR-708-5p/GIT2 axis." 1 circPTN Promotes the Progression of Non-Small Cell Lung Cancer through Upregulation of E2F2 by Sponging miR-432-5p. - hsa_circ_PTN circPTN DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circPTN regulates the malignant progression of NSCLC cells through targeting the miR-432-5p/E2F2 axis. 1 Has_circ_0010220 regulates the miR-574-3p/IL-6 axis to increase doxorubicin resistance in osteosarcoma. hsa_circ_0010220 hsa_circ_ARHGEF10L circ_0010220 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Hsa_circ_0010220 encouraged OS resistance to DOX by miR-574-3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS." 3 Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression. - hsa_circ_AR-3 circAR-3 DOID:10283 prostate cancer prostate cancer RT-qPCR dysregulated circAR-3 mediated the acetylation modification of NLRP3 by KAT2B and then promoted NLRP3 inflammasome complex subcellular distribution and assembly. 1 circBGN accelerates gastric cancer cell proliferation and invasion via activating IL6/STAT3 signaling pathway. - hsa_circ_BGN circBGN DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated circBGN regulates GC cell proliferation and invasion by upregulating miR-149-5p/IL6 axis output. 2 CircRNA GRB10 is a Novel Biomarker for the Accurate Diagnosis of Lumbar Degenerative Disc Disease. - hsa_circ_GRB10 circRNA GRB10 DOID:90 degenerative disc disease lumbar degenerative disc disease RT-qPCR down-regulated GRB10 was downregulated in LDDD and may serve as a biomarker for the accurate diagnosis of LDDD. 3 Circ_0101874 overexpression strengthens PDE4D expression by targeting miR-335-5p to promote neuronal injury in ischemic stroke. hsa_circ_0101874 - circ_0101874 DOID:3526 cerebral infarction Ischemic stroke RT-qPCR up-regulated Circ_0101874 knockdown alleviated OGD-induced neuronal cell injury by suppressing PDE4D via regulating miR-335-5p. 1 CircPalm2 knockdown alleviates LPS-evoked pulmonary microvascular endothelial cell apoptosis and inflammation via miR-450b-5p/ROCK1 axis. - mmu_circ_Palm2 circPalm2 DOID:850 lung disease acute lung injury RT-qPCR up-regulated "CircPalm2 knockdown can alleviate LPS-evoked MPVEC apoptosis and inflammation via miR-450b-5p/ROCK1 axis, suggesting the potential involvement of this ceRNA network in sepsis-ALI and a broader approach for the therapy of sepsis-ALI." 1 Circ_0026123 promotes cisplatin resistance and progression of ovarian cancer by upregulating RAB1A through sequestering miR-543. hsa_circ_0026123 - Circ_0026123 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "circ_0026123 acted as a sponge for miR-543 to elevate RAB1A expression, thus promoting cisplatin resistance and tumorigenesis in ovarian cancer." 2 Spinal CircKcnk9 Regulates Chronic Visceral Hypersensitivity of Irritable Bowel Syndrome. - rno_circ_Kcnk9 CircKcnk9 DOID:9778 irritable bowel syndrome irritable bowel syndrome "RT-qPCR, RNA-seq" up-regulated Spinal circKcnk9 functions as a miR-124-3p sponge to promote visceral hypersensitivity by regulating the STAT3/NSF/GluR2 pathway. 2 CircUBXN7 suppresses cell proliferation and facilitates cell apoptosis in lipopolysaccharide-induced cell injury by sponging miR-622 and regulating the IL6ST/JAK1/STAT3 axis. - hsa_circ_UBXN7 CircUBXN7 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome RT-qPCR up-regulated "circUBXN7 suppressed cell proliferation and facilitated cell apoptosis by sponging miR-622 and regulating IL6ST, to activate the JAK1/STAT3 signaling pathway in LPS-induced A549 and Beas-2B cell injury." 1 Hsa_circ_0001445 works as a cancer suppressor via miR-576-5p/SFRP1 axis regulation in ovarian cancer. hsa_circ_0001445 hsa_circ_SMARCA5 circ_0001445 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated hcR1445 acts an antioncogene by targeting the miR-576-5p/SFRP1 axis and blocking OC progression and development. 1 The Elevated Circ_0067835 Could Accelerate Cell Proliferation and Metastasis via miR-1236-3p/Twist2 Axis in Hepatocellular Carcinoma. hsa_circ_0067835 - Circ_0067835 DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray up-regulated circ_0067835 contributed to promoting hepatocellular carcinoma cell proliferation and metastasis through downregulating miR-1236-3p expression and then elevating Twist2 expression. 1 "Circular RNA hsa_circ_0003823 promotes the Tumor Progression, Metastasis and Apatinib Resistance of Esophageal Squamous Cell Carcinoma by miR-607/CRISP3 Axis." hsa_circ_0003823 hsa_circ_CEP70 - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RNA-seq up-regulated "hsa_circ_0003823 and its role in promoting tumor progression, metastasis and Apatinib resistance of ESCC through miR-607/CRISP3 axis." 1 Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease. - hsa_circ_HIPK3 CircHIPK3 DOID:557 kidney disease diabetic kidney disease RT-qPCR up-regulated "circHIPK3 facilitates the enrichment of fused in sarcoma (FUS) on the ectodysplasin A2 receptor (EDA2R) promoter, resulting in the upregulation of EDA2R expression and activation of apoptotic signaling." 3 Downregulationof circ_0001578 promotes gestational diabetes mellitus by inducing placental inflammation via the NF-kappaB and JNKs pathways. hsa_circ_0001578 - circ_0001578 DOID:11714 gestational diabetes gestational diabetes mellitus "RT-qPCR, RNA-seq" down-regulated the downregulation of circ_0001578 may promote GDM by inducing chronic inflammation in the placenta via the NF-kappaB and JNK pathways. 1 Circular RNA_0076977 contributes to oral squamous cell carcinoma progression through mediating microRNA-802 axis. hsa_circ_0076977 - Circ_0076977 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Circ_0076977 was up-regulated in OSCC tissues and cell lines, and high circ_0076977 expression contributed to OSCC progression by targeting miR-802/MYO6 axis." 1 CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. - hsa_circ_LRFN5 CircLRFN5 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. 1 Hsa_circ_0099630 knockdown induces the proliferation and osteogenic differentiation and attenuates the apoptosis of porphyromonas gingivalis lipopolysaccharide-induced human periodontal ligament fibroblasts. hsa_circ_0099630 - circ_0099630 DOID:824 periodontitis periodontitis "RT-qPCR, RNA-seq" up-regulated Hsa_circ_0099630 knockdown induces the proliferation and osteogenic differentiation and attenuates the apoptosis of porphyromonas gingivalis lipopolysaccharide-induced human periodontal ligament fibroblasts. 3 Circ_0001658 regulates PI3K/AKT signaling via the miR-671-5p/ITGA2 axis and affects the progress of papillary thyroid carcinoma. hsa_circ_0001658 - Circ_0001658 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated circ_0001658 is a carcinogenesis-associated circRNA that regulates PI3K/AKT signaling via the miR-671-5p/ITGA2 axis and plays a role in promoting the progression of PTC. 1 circMTND5 Participates in Renal Mitochondrial Injury and Fibrosis by Sponging MIR6812 in Lupus Nephritis. - hsa_circ_MTND5 circMTND5 DOID:0080162 lupus nephritis lupus nephritis "RT-qPCR, RNA-seq" down-regulated circMTND5 Participates in Renal Mitochondrial Injury and Fibrosis by Sponging MIR6812 in Lupus Nephritis. 1 Knockdown of circGOLPH3 inhibits cell progression and glycolysis by targeting miR-145-5p/lysine demethylase 2A (KDM2A) axis in oral squamous cell carcinoma. - hsa_circ_GOLPH3 circGOLPH3 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated circGOLPH3 exerted pro-oncogenic effects through the miR-145-5p/KDM2A axis to regulate OSCC cell behaviors. 2 Serum hsa_circ_0000615 is a prognostic biomarker of sorafenib resistance in hepatocellular carcinoma. hsa_circ_0000615 hsa_circ_ZNF609 circ_0000615 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Serum hsa_circ_0000615 is a prognostic biomarker of sorafenib resistance in hepatocellular carcinoma. 2 "Circ_FOXO3 regulates KLF6 through sponge adsorption of miR-122-5p to repress H2O2-induced HBVSMC proliferation, thus promoting IA development in vitro model." - hsa_circ_FOXO3 Circ_FOXO3 DOID:10941 intracranial aneurysm intracranial aneurysms RT-qPCR up-regulated circ_FOXO3 suppresses H2O2-induced proliferation of HBVSMC but promotes apoptosis via modulation of miR-122-5p/KLF6 axis. 1 circ_0025033 promotes ovarian cancer development via regulating the hsa_miR-370-3p/SLC1A5 axis. hsa_circ_0025033 - circ_0025033 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated circ_0025033 affected SLC1A5 via regulating hsa_miR-370-3p. CONCLUSION: circ_0025033 might promote ovarian cancer progression via hsa_miR-370-3p/SLC1A5. 4 Microarray Profile of Circular RNAs Identifies hsa_circ_0001583 as A New Circular RNA Biomarker for Breast Cancer: A Retrospective Study. hsa_circ_0001583 hsa_circ_HIST1H1C - DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated Hsa_circ_0001583 showed significant up-regulation in BC patients with paired adjacent tissues. 2 Lead exposure promotes the inflammation via the circRNA-05280/miR-146a/IRAK1 axis in mammary gland. - - circRNA-05280 DOID:0060501 metal allergy heavy metal "RT-qPCR, RNA-seq" up-regulated "This study concludes that circRNA-05280/ miR-146a/ IRAK1 signaling pathway could mediate the mammary gland damage resulting from lead exposure. Accordingly, it sheds new light on further exploration of molecular mechanisms of mammary gland tissue damage caused by lead exposure, the risk assessment of lead, and the mechanism of lead mammary gland toxicity." 1 Silencing of circCYP51A1 represses cell progression and glycolysis by regulating miR-490-3p/KLF12 axis in osteosarcoma under hypoxia. - hsa_circ_CYP51A1 circCYP51A1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "CircCYP51A1 mediated cell proliferation, migration, invasion and glycolysis by regulating miR-490-3p/KLF12 axis in OS cells under hypoxia condition." 3 Downregulation of Circ-PITHD1 Suppressed Colorectal Cancer via Glycolysis Inhibition through miR-590-5p/HK2 Axis. - hsa_circ_PITHD1 Circ-PITHD1 DOID:9256 colorectal cancer colorectal cancer RNA-seq up-regulated circ-PITHD1 downregulation suppressed CRC progression by inhibiting glycolysis via the miR-590-5p/HK2 axis. 1 circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis. - hsa_circ_MSR circRNA-MSR DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "circRNA-MSR could affect FBXO21 level via targeting miR-761, thereby repressing autophagy in OA chondrocytes." 1 Circ_0008234 regulates the biological process of gallbladder carcinoma by targeting the miR-204-5p/FGFR2 axis. hsa_circ_0008234 - Circ_0008234 DOID:3121 gallbladder cancer gallbladder cancer RT-qPCR up-regulated "Circ_0008234 mediated GBC via the miR-204-5p/FGFR2 axis, providing a novel targeted therapy for gallbladder carcinoma." 1 Application of Circular RNA Circ_0071662 in the Diagnosis and Prognosis of Hepatocellular Carcinoma and Its Response to Radiotherapy. hsa_circ_0071662 - Circ_0071662 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated Circ_0071662 was downregulated in HCC and may serve as a potential biomarker to improve the diagnosis of HCC. 1 A Novel Protein Encoded by Exosomal CircATG4B Induces Oxaliplatin Resistance in Colorectal Cancer by Promoting Autophagy. - hsa_circ_ATG4B CircATG4B DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated A Novel Protein Encoded by Exosomal CircATG4B Induces Oxaliplatin Resistance in Colorectal Cancer by Promoting Autophagy. 1 Hsa_circ_0093741 competes with FRS2 for miR-562 binding sites to promote nephroblastoma progression. hsa_circ_0093741 hsa_circ_PCDH15 circ_0093741 DOID:2154 nephroblastoma nephroblastoma RT-qPCR up-regulated "Knockdown of hsa_circ_0093741 suppresses nephroblastoma cell growth, migration and invasion by regulating the miR-562/FRS2 axis, suggesting the potential involvement of hsa_circ_0093741 in nephroblastoma progression." 1 Circ_0001667 Promotes Adriamycin Resistance and Malignant Progression via Targeting the miR-193a-5p/Rap2A Molecular Axis in Breast Cancer. hsa_circ_0001667 - Circ_0001667 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated circ_0001667 contributed to ADM resistance and tumor development in BC via the miR-193a-5p-mediated Rap2A expression change. 4 The circular RNA circ_0099630/miR-940/receptor-associated factor 6 regulation cascade modulates the pathogenesis of periodontitis. hsa_circ_0099630 - circ_0099630 DOID:824 periodontitis periodontitis RT-qPCR up-regulated Silencing circ_0099630 alleviates LPS-induced periodontal ligament cell injury via targeting miR-940/TRAF6/NF-kappaB in periodontitis. 3 "Identification of a dysregulated CircRNA-associated gene signature for predicting prognosis, immune landscape, and drug candidates in bladder cancer." hsa_circ_0067900 hsa_circ_PHC3 circ_0067900 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "the overexpression of has_circ_0067900 significantly impaired the proliferation, migration, and invasion capacities of BCa cells." 1 Circ_0085616 contributes to the radio-resistance and progression of cervical cancer by targeting miR-541-3p/ARL2 signaling. hsa_circ_0085616 - Circ_0085616 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Circ_0085616 contributed to the radio-resistance and progression of cervical cancer partly through mediating the miR-541-3p/ARL2 axis. 2 Exosomal hsa_circRNA_047733 integrated with clinical features for preoperative prediction of lymph node metastasis risk in oral squamous cell carcinoma. - - circRNA_047733 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, microarray" down-regulated exosomal hsa_circRNA_047733 might be a novel biomarker for the LNM of OSCC. 1 Hsa_circ_0043949 reinforces temozolomide resistance via upregulating oncogene ITGA1 axis in glioblastoma. hsa_circ_0043949 hsa_circ_BRCA1 circ_0043949 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "TMZ-resistant GBM cells-derived exosomal circ_0043949 promoted TMZ resistance via upregulating ITGA1 expression via sequestering miR-876-3p, offering a potential target for the treatment of TMZ resistance in GBM." 2 Circ_0002099 is a novel molecular therapeutic target for bladder cancer. hsa_circ_0002099 - Circ_0002099 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated FUS-medicated Circ_0002099 could promote the epithelial-mesenchymal transition process in BLCA progression via miR-217-5p/miR-103a-3p/KRAS axis-WNT/beta-catenin axi. 1 circEXOC5 promotes acute lung injury through the PTBP1/Skp2/Runx2 axis to activate autophagy. - hsa_circ_EXOC5 circEXOC5 DOID:850 lung disease acute lung injury RT-qPCR up-regulated "The signaling cascade circEXOC5/PTBP1/Skp2/Runx2, by essentially regulating inflammation and autophagy in MPVECs, aggravates sepsis-induced ALI." 1 Hsa_circ_0008870 suppresses bone formation of growth plate through inhibition of miR-185-3p/ MAPK1 axis in idiopathic short stature. hsa_circ_0008870 hsa_circ_MAPK1 circ_0008870 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer "RT-qPCR, RNA-seq" up-regulated "CircNDST1 bonded with CSNK2A1 and promoted the interaction between CSNK2A1 and Akt, leading to the activation of the PI3K-Akt pathway and EMT." 1 "Hsa_circ_0005529 promotes ZEB1 expression by regulating miR-873-5p and enhancing proliferation, invasion, and migration in gastric cancer cell lines." hsa_circ_0005529 hsa_circ_VPS33B circ_0005529 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated hsa_circ_0005529 promoted tumorigenic behavior in gastric cancer cells by adsorbing miR-873-5p to modulate ZEB1 levels. This suggests that hsa_circ_0005529 may be useful as a biomarker and target for diagnosing and treating gastric cancer. 3 CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition. - hsa_circ_NDST1 CircNDST1 DOID:1781 thyroid gland cancer thyroid cancer "RT-qPCR, RNA-seq" up-regulated CircNDST1s high expression boosted thyroid cancer progression through the activation of the PI3K-Akt pathway and EMT in a CSNK2A1-dependent manne. 1 CircHIPK3 promotes neuroinflammation through regulation of the miR-124-3p/STAT3/NLRP3 signaling pathway in Parkinson disease. - hsa_circ_HIPK3 CircHIPK3 DOID:14330 Parkinson disease Parkinson disease RT-qPCR up-regulated The circHIPK3 enhances neuroinflammation by sponging miR-124 and regulating the miR-124-mediated STAT3/NALP3 pathway in PD. 1 CircHADHA-augmented autophagy suppresses tumor growth of colon cancer by regulating autophagy-related gene via miR-361. - hsa_circ_HADHA CircHADHA DOID:219 colon cancer colon cancer microarray up-regulated CircHADHA-augmented autophagy suppresses tumor growth of colon cancer by regulating autophagy-related gene via miR-361. 1 CircRNA_45478 promotes ischemic AKI by targeting the miR-190a-5p/PHLPP1 axis. - - CircRNA_45478 DOID:3021 acute kidney failure acute kidney injury RT-qPCR dysregulated "circRNA_45478 upregulated the expression of Pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase 1 (PHLPP1) via sponging of microRNA (miR)-190a-5p. Finally, inhibition of circRNA_45478 significantly alleviated the progression of ischemic AKI through regulation of the miR-190a-5p/PHLPP1 pathway." 1 Circ_0031027 adjusts the advancement of cervical cancer by miR-587/SOCS5 axis. hsa_circ_0031027 - Circ_0031027 DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated Circ_0031027 inhibited the enlargement of CC by miR-587/SOCS5. 1 Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair. - hsa_circ_BNC2 circBNC2 DOID:0050855 renal fibrosis fibrogenic responses after injury "RT-qPCR, RNA-seq" down-regulated Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair 1 Circ_0008529 Contributes to Renal Tubular Cell Dysfunction in High Glucose Stress via miR-185-5p/SMAD2 Pathway in Diabetic Nephropathy. hsa_circ_0008529 - circ_0008529 DOID:9743 diabetic neuropathy diabetic nephropathy RT-qPCR up-regulated "Circ_0008529 might be a potential target for DN, which regulated DN progression via miR-185-5p/SMAD2 pathway." 2 [hsa_circ_0000231 affects the progression of tongue squamous cell carcinoma by activating Wnt/beta-catenin signaling pathway]. hsa_circ_0000231 hsa_circ_ARHGAP12 circ_0000231 DOID:50865 tongue squamous cell carcinoma tongue squamous cell carcinoma RT-qPCR up-regulated "hsa_circ_0000231 is an independent prognostic factor of TSCC. Highly expressed hsa_circ_0000231 can promote the proliferation, invasion and metastasis of TSCC cells." 2 Ectopic circSTK39 Expression Ameliorates Hydrogen Peroxide-Induced Human Lens Epithelial Cell Apoptosis and Oxidative Stress through the miR-125a-5p/ERCC6 Pathway. - hsa_circ_STK39 circSTK39 DOID:0070353 cataract age-related cataract RT-qPCR down-regulated The increased expression of circSTK39 ameliorated H(2)O(2)-induced SRA01/04 cell injury through the miR-125a-5p/ERCC6 pathway. 1 Exosomal circ_0091741 promotes gastric cancer cell autophagy and chemoresistance via the miR-330-3p/TRIM14/Dvl2/Wnt/beta-catenin axis. hsa_circ_0091741 - circ_0091741 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Exosomal circ_0091741 promotes gastric cancer cell autophagy and chemoresistance via the miR-330-3p/TRIM14/Dvl2/Wnt/beta-catenin axis. 1 CircUCK2 regulates HECTD1-mediated endothelial-mesenchymal transition inhibition by interacting with FUS and protects the blood-brain barrier in ischemic stroke. - hsa_circ_UCK2 CircUCK2 DOID:6713 cerebrovascular disease Ischemic stroke RT-qPCR down-regulated circUCK2 upregulates the expression of HECTD1 by combining with FUS and inhibits EndoMT to alleviate BBB damage in IS both in vivo and in vitro. 1 Propofol inhibits glioma progression by regulating circMAPK4/miR-622/HOXA9 axis. - hsa_circ_MAPK4 circMAPK4 DOID:0060108 brain glioma glioma RT-qPCR dysregulated "Propofol restrains glioma cell growth, migration and invasion. circMAPK4 can regulate HOXA9 by sponging miR-622 in glioma cells." 2 Circ_0015756 promotes ovarian cancer progression via the miR-145-5p/PSAT1 axis. hsa_circ_0015756 - Circ_0015756 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "circ_0015756 accelerated OC tumorigenesis through regulating miR-145-5p/PSAT1 axis, providing a new therapeutic target for OC." 2 circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer. - hsa_circ_CAPRIN1 circCAPRIN1 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated circCAPRIN1 interacted with STAT2 to promote CRC tumor progression and lipid synthesis by enhancing the expression of ACC. 1 Identification of circular RNA BTBD7_hsa_circ_0000563 as a novel biomarker for coronary artery disease and the functional discovery of BTBD7_hsa_circ_0000563 based on peripheral blood mononuclear cells: a case control study. hsa_circ_0000563 - hsa_circ_0000563 DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, RNA-seq" down-regulated BTBD7_hsa_circ_0000563 may be a novel biomarker for the diagnosis of CAD and may influence the initiation and progression of CAD. 1 "[CircPCSK5 is highly expressed in gastric cancer and promotes cancer cell proliferation, invasion and epithelial-mesenchymal transition]." - hsa_circ_PCSK5 CircPCSK5 DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" up-regulated "CircPCSK5 is highly expressed in GC and promotes the proliferation, invasion and EMT of GC cells, suggesting its potential as a prognostic biomarker and therapeutic target for GC." 1 CircHSPG2 absence weakens hypoxia-induced dysfunction in cardiomyocytes by targeting the miR-25-3p/PAWR axis. - hsa_circ_HSPG2 CircHSPG2 DOID:5844 myocardial infarction hypoxia-induced myocardial Infarction RT-qPCR up-regulated CircHSPG2 silencing protected AC-16 cells against hypoxia-induced dysfunction by targeting miR-25-3p/PAWR axis. 1 "Circ_0000284 facilitates the growth, metastasis and glycolysis of intrahepatic cholangiocarcinoma through miR-152-3p-mediated PDK1 expression." hsa_circ_0000284 - Circ_0000284 DOID:4928 intrahepatic cholangiocarcinoma intrahepatic cholangiocarcinoma RT-qPCR up-regulated "Circ_0000284 promoted the growth, metastasis and glycolysis of ICC by miR-152-3p/PDK1 pathway." 1 CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis. - hsa_circ_RAD54L2 CircRAD54L2 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis. 1 CircIRAK1 aggravates ox-LDL-induced endothelial cell injury in atherosclerosis via TRIM14 upregulation by binding to miR-330-5p1. - hsa_circ_IRAK1 CircIRAK1 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "circIRAK1 upregulated TRIM14 by interacting with miR-330-5p, consequently contributing to ox-LDL-induced endothelial cell injury in AS." 1 Predicting the influence of Circ_0059706 expression on prognosis in patients with acute myeloid leukemia using classical statistics and machine learning. hsa_circ_0063331 hsa_circ_ID1 Circ_0059706 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated high expression of circ_0059706 is propitious for patient prognosis and suggest circ_0059706 as a potential new biomarker for diagnosis and prognosis evaluation in AML. 1 Hsa_circ_0040809 and hsa_circ_0000467 promote colorectal cancer cells progression and construction of a circRNA-miRNA-mRNA network. hsa_circ_0040809 hsa_circ_BANP - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "hsa_circ_0040809 and hsa_circ_0000467 were upregulated in CRC tissues and cell lines, and promoted CRC cell progression." 3 Hsa_circ_0040809 and hsa_circ_0000467 promote colorectal cancer cells progression and construction of a circRNA-miRNA-mRNA network. hsa_circ_0000467 hsa_circ_SKA3 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "hsa_circ_0040809 and hsa_circ_0000467 were upregulated in CRC tissues and cell lines, and promoted CRC cell progression." 4 Potential predictive and therapeutic applications of small extracellular vesicles-derived circPARD3B in osteoarthritis. - hsa_circ_PARD3B circPARD3B DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated Serum sEV circPARD3B is a potential biomarker that enables the identification of the inflammatory phenotype of patients with OA. 2 Hsa_circ_0097271 Knockdown Attenuates Osteosarcoma Progression via Regulating miR-640/MCAM Pathway. hsa_circ_0097271 - circ_0097271 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circ_0097271 is an oncogenic driver and contributes to OS development via targeting the miR-640/MCAM pathway. 1 CircSCNN1A is a tumor suppressor in renal cell carcinoma via inducing the upregulation of MPP7 by the sponge effect on miR-421. hsa_circ_0025135 hsa_circ_SCNN1A CircSCNN1A DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR down-regulated "circSCNN1A upregulated the expression of MPP7 via sponging miR-421, then inhibiting the progression of RCC." 1 CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy. - hsa_circ_FOXO3 CircFOXO3 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy. 1 circRanGAP1/miR-27b-3p/NRAS Axis may promote the progression of hepatocellular Carcinoma. - hsa_circ_RanGAP1 circRanGAP1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circRanGAP1 is a HCC oncogene that function by the miR-27b-3p/NRAS/ERK axis and regulates the infiltration levels of tumor-associated macrophages by sponging miR-27b-3p. 1 Whole blood circular RNA hsa_circ_0002171 serves as a potential diagnostic biomarker for human adenovirus pneumonia in children. hsa_circ_0002171 hsa_circ_C5orf25 - DOID:552 pneumonia severe pneumonia related to human adenoviruses microarray up-regulated hsa_circ_0002171 had a significant value in the diagnosis of HAdV pneumonia and of severe HAdV pneumonia. 1 "Circular RNA hsa_circ_0023404 promotes the proliferation, migration and invasion in endometrial cancer cells through regulating miR-217/MAPK1 axis." hsa_circ_0023404 hsa_circ_RNF121 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "hsa_circ_0023404 promotes the proliferation, migration and invasion in endometrial cancer cells through regulating miR-217/MAPK1 axis." 1 Circular RNA ciRS-7 promotes laryngeal squamous cell carcinoma development by inducing TGM3 hypermethylation via miR-432-5p/DNMT3B axis. - - ciRS-7 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated ciRS-7 promotes the progression of LSCC through increasing TGM3 methylation via miR-432-5p/DNMT3B axis. 1 Hsa_circ_0069094 positively regulates the expression of oncogenic ZNF217 by competitively targeting miR-758-3p to promote the development of breast cancer. hsa_circ_0069094 hsa_circ_S100P circ_0069094 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Hsa_circ_0069094 played oncogenic effects in breast cancer by activating the expression of ZNF217 via competitively binding to miR-758-3p. 4 CircRNA hsa_circ_0001627 aggravates cervical cancer progression through upregulation of FNDC3B and activating PI3K/mTOR signaling pathway. hsa_circ_0001627 hsa_circ_BACH2 - DOID:4362 cervical cancer cervical cancer microarray up-regulated hsa_circ_0001627 regulates miR-1225-5p/FNDC3B/PI3K/mTOR axis and functions as an oncogene in CC progression. 1 PRP8-Induced CircMaml2 Facilitates the Healing of the Intestinal Mucosa via Recruiting PTBP1 and Regulating Sec62. - hsa_circ_Maml2 CircMaml2 DOID:77 gastrointestinal system disease ultiple organ dysfunction syndrome microarray dysregulated "CircMaml2 promotes cell proliferation and migration of MC38 cells and the repair of the intestinal mucosa of mice. This effect is brought about by combining with PTBP1 to improve Ebf1 and interacting with miR-683 to regulate Sec2. Furthermore, PRP8 was discovered to promote the biogenesis of circMaml2. " 1 A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer Disease and Mild Cognitive Impairment from Healthy Controls. - - circrna_050263 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "A validation study was carried out on four up-regulated (hsa_circRNA_050263, hsa_circRNA_403959, hsa_circRNA_003022, hsa_circRNA_100837) and two down-regulated (hsa_circRNA_102049, hsa_circRNA_102619) circRNAs in a larger population." 1 A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer Disease and Mild Cognitive Impairment from Healthy Controls. - - hsa_circRNA_403959 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "A validation study was carried out on four up-regulated (hsa_circRNA_050263, hsa_circRNA_403959, hsa_circRNA_003022, hsa_circRNA_100837) and two down-regulated (hsa_circRNA_102049, hsa_circRNA_102619) circRNAs in a larger population." 1 A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer Disease and Mild Cognitive Impairment from Healthy Controls. hsa_circ_003022 - hsa_circRNA_003022 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "A validation study was carried out on four up-regulated (hsa_circRNA_050263, hsa_circRNA_403959, hsa_circRNA_003022, hsa_circRNA_100837) and two down-regulated (hsa_circRNA_102049, hsa_circRNA_102619) circRNAs in a larger population." 1 A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer Disease and Mild Cognitive Impairment from Healthy Controls. - - hsa_circRNA_100837 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" up-regulated "A validation study was carried out on four up-regulated (hsa_circRNA_050263, hsa_circRNA_403959, hsa_circRNA_003022, hsa_circRNA_100837) and two down-regulated (hsa_circRNA_102049, hsa_circRNA_102619) circRNAs in a larger population." 1 A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer Disease and Mild Cognitive Impairment from Healthy Controls. - - hsa_circRNA_102049 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "A validation study was carried out on four up-regulated (hsa_circRNA_050263, hsa_circRNA_403959, hsa_circRNA_003022, hsa_circRNA_100837) and two down-regulated (hsa_circRNA_102049, hsa_circRNA_102619) circRNAs in a larger population." 1 A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer Disease and Mild Cognitive Impairment from Healthy Controls. - - hsa_circRNA_102619 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, microarray" down-regulated "A validation study was carried out on four up-regulated (hsa_circRNA_050263, hsa_circRNA_403959, hsa_circRNA_003022, hsa_circRNA_100837) and two down-regulated (hsa_circRNA_102049, hsa_circRNA_102619) circRNAs in a larger population." 1 Gastric Cancer Growth Modulated by circSNTB2/miR-6938-5p/G0S2 and PDCD4. hsa_circ_0040039 hsa_circ_SNTB2 circSNTB2 DOID:10534 stomach cancer gastric cancer microarray down-regulated circSNTB2 plays an essential role in gastric cancer by regulating miR-6938-5p through G0S2 and PDCD4 genes. 1 Hypoxia-induced circRNF13 promotes the progression and glycolysis of pancreatic cancer. - hsa_circ_RNF13 circRNF13 DOID:1793 pancreatic cancer pancreatic cancer RNA-seq up-regulated hypoxia-induced circRNF13 mediated by HIF-1alpha and EIF4A3 promotes tumor progression and glycolysis in PC. 2 Circ_0000471 suppresses the progression of ovarian cancer through mediating mir-135b-5p/dusp5 axis. hsa_circ_0000471 - Circ_0000471 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "Overexpression of circ_0000471 inhibited OC development by targeting miR-135b-5p/DUSP5 axis, indicating that circ_0000471 may be a new potential target for OC treatment." 1 N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells. - hsa_circ_QSOX1 circQSOX1 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "m(6)A-modified circQSOX1 facilitated CRC tumorigenesis by sponging miR-326 and miR-330-5p to promotes PGAM1 expression, which further promoted CRC immune escape by activating glycolysis and inactivating the anti-CTLA-4 therapy response of CRC." 1 Knockdown of hsa_circ_0043691 restrains the progression of gastric cancer by decoying miR-1294 to target pre-leukemia transcription factor 3. hsa_circ_0043691 hsa_circ_NT5C3L circ_0043691 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Hsa_circ_0043691 knockdown repressed GC malignant phenotypes by miR-1294/PBX3 axis. 2 CircCHD2/miR-200b-3p/HLF Axis Promotes Liver Cirrhosis. - hsa_circ_CHD2 CircCHD2 DOID:5082 liver cirrhosis liver cirrhosis RT-qPCR up-regulated A loss of circCHD2/miR-200b-3p/HLF axis contributed to alleviate LC progression. 1 "CircTFF1 Promotes Proliferation, Migration and Invasion of Lung Cancer Cells by Facilitating Methylation of BCL6B Promoter via miR-29c-3p/DNMT3A Axis." - hsa_circ_TFF1 CircTFF1 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "circTFF1 promoted proliferation, migration and invasion of lung cancer cell lines by facilitating methylation of BCL6B promoter via miR-29c-3p/DNMT3A axis." 1 Circ_MBNL3 Restrains Hepatocellular Carcinoma Progression by Sponging miR-873-5p to Release PHF2. - hsa_circ_MBNL3 Circ_MBNL3 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Circ_MBNL3 restrained the proliferation, migration, and invasion and promoted the apoptosis of HCC cells depending on the regulation of miR-873-5p/PHF2 axi." 2 Circ_0079530 stimulates THBS2 to promote the malignant progression of non-small cell lung cancer by sponging miR-584-5p. hsa_circ_0079530 - Circ_0079530 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0079530 promoted NSCLC progression by regulating the miR-584-5p/THBS2 axis. 3 Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma. hsa_circ_0084043 - Circ_0084043 DOID:1909 melanoma melanoma RT-qPCR up-regulated Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma. 3 Circular RNA hsa_circ_0003892 promotes the development of papillary thyroid carcinoma by regulating the miR-326/LASP1 axis. hsa_circ_0003892 hsa_circ_LDLR - DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated Circ_0003892 up-regulates LASP1 expression and facilitates PTC progression via competitively binding to miR-326. 3 Hsa_circ_0094606 promotes malignant progression of prostate cancer by inducing M2 polarization of macrophages through PRMT1-mediated arginine methylation of ILF3. hsa_circ_0094606 hsa_circ_SORBS1 circ_0094606 DOID:10283 prostate cancer prostate cancer RT-qPCR dysregulated Hsa_circ_0094606 promotes malignant progression of prostate cancer by inducing M2 polarization of macrophages through PRMT1-mediated arginine methylation of ILF3. 1 "A circular RNA, circPTPN14, increases MYC transcription by interacting with FUBP1 and exacerbates renal fibrosis." - hsa_circ_PTPN14 circPTPN14 DOID:0050855 renal fibrosis renal fibrosis RT-qPCR up-regulated "circPTPN14, increases MYC transcription by interacting with FUBP1 and exacerbates renal fibrosis." 1 Hypoxia-induced circADAMTS6 in a TDP43-dependent manner accelerates glioblastoma progression via ANXA2/ NF-kappaB pathway. hsa_circ_0072688 hsa_circ_ADAMTS6 circ-0072688 DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq, microarray" up-regulated Hypoxia-induced circADAMTS6 in a TDP43-dependent manner accelerates glioblastoma progression via ANXA2/ NF-kappaB pathway. 1 Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1. - hsa_circ_PTPRF circPTPRF DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression." 1 Hypoxia-induced Circular RNA hsa_circ_0006508 Promotes the Warburg Effect in Colorectal Cancer Cells. hsa_circ_0006508 hsa_circ_VMP1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0006508-mediated miR-1272 inhibition could promote the malignant behaviors of colorectal cancer with an upregulated Warburg effect. 1 Bioinformatic analysis and clinical diagnostic value of hsa_circ_0004099 in acute ischemic stroke. hsa_circ_0004099 hsa_circ_DENND5A circ_0004099 DOID:2316 brain ischemia acute ischemic stroke RT-qPCR dysregulated hsa_circ_0004099 is a potential clinical diagnostic marke. 1 CircRNA AFF4 induced by KDM1A promotes osteogenic differentiation through FNDC5/Irisin pathway. - hsa_circ_AFF4 circ_AFF4 DOID:12347 osteogenesis imperfecta osteogenesis RT-qPCR up-regulated "KDM1A induces circ_AFF4, which promotes promote osteogenesis via IGF2BP3." 1 Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling. - hsa_circ_RIG-I circRIG-I DOID:219 colon cancer colon cancer RT-qPCR up-regulated "circRIG-I interacts with DDX3X, which in turn stimulates MAVS/TRAF5/TBK1 signaling cascade, eventually activating IRF3-mediated type I IFN transcription and aggravating inflammatory damage." 1 Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis. hsa_circ_0006916 hsa_circ_HOMER1 - DOID:3770 pulmonary fibrosis ulmonary fibrosis "RT-qPCR, RNA-seq" up-regulated "knockdown of hsa_circ_0006916 significantly increased the expression levels of M1 molecules IL-1beta and TNF-alpha and reduced the expression level of M2 molecule TGF-beta1, indicating that hsa_circ_0006916 may play an important role in the activation of M1-M2 polarization effect in macrophages." 1 Hsa_Circ_0066351 Acts as a Prognostic and Immunotherapeutic Biomarker in Colorectal Cancer. hsa_circ_0066351 hsa_circ_FLNB Circ_0066351 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "A novel circRNA (hsa_circ_0066351) inhibited CRC proliferation, and revealed a potential prognostic and immunotherapeutic biomarker in CRC." 1 Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy. hsa_circ_0007006 hsa_circ_DYM - DOID:81120 Graves ophthalmopathy thyroid-associated ophthalmopathy "RT-qPCR, RNA-seq" up-regulated hsa_circ_0007006-COL1A1 and MMP2-relaxin signaling pathways are important regulatory axes in the pathogenesis of this disease type . 1 Inhibition of circ_0004381 improves cognitive function via miR-647/PSEN1 axis in an Alzheimer disease mouse model. hsa_circ_0004381 - circ_0004381 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated "knockdown of circ_0004381 attenuated hippocampal neuronal damage and promoted microglia M2-type polarization through the miR-647/PSEN1 axis, ultimately improving cognitive function in AD model mice." 1 has_circ_0070512 promotes prostate cancer progression by regulating the miR-338-3p/hedgehog signaling pathway. hsa_circ_0070512 hsa_circ_PPP3CA circ_0070512 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated hsa_circ_0070512 regulated the hedgehog signaling pathways through miR-338-3p to enhance PCa growth and migration. 1 hsa_circ_0038382 upregulates T-box transcription factor 5 to inhibit keloid formation by interacting with miR-940. hsa_circ_0038382 hsa_circ_GPRC5B circ_0038382 DOID:10881 "hand, foot and mouth disease" keloid formation RT-qPCR down-regulated hsa_circ_0038382 attenuates keloid formation by regulating the miR-940/TBX5 axis. 1 CircRNA hsa_circ_0075048 promotes the malignant progression of non-small cell lung cancer by up-regulating HMGB2 expression via targeting miR-1225-5p. hsa_circ_0075048 hsa_circ_ERGIC1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ_0075048 played an oncogenic role in the development of NSCLC by regulating miR-1225-5p and HMGB2. 1 CircWDR33 alleviates human pulmonary microvascular endothelial cell injury in sepsis-associated acute lung injury by targeting miR-217-5p/SERP1 axis. - hsa_circ_WDR33 circWDR33 DOID:850 lung disease acute lung injury RT-qPCR down-regulated "CircWDR33 protected against LPS-induced inflammatory and apoptotic injury, permeability enhancement and tubule formation arrest in HPMECs via miR-217-5p/SERP1 axis, indicating a new potential therapeutic approach for sepsis-ALI patients." 1 circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells. - hsa_circ_PRKAA1 circPRKAA1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells. 1 Novel hypoxia-induced HIF1alpha-circTDRD3-positive feedback loop promotes the growth and metastasis of colorectal cancer. - hsa_circ_TDRD3 circTDRD3 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" up-regulated "circTDRD3 facilitates the proliferation and metastasis of CRC through a positive feedback loop mediated by the HIF1alpha/PTBP1/circTDRD3/miR-1231/HIF1alpha axis. Therefore, circTDRD3 may serve as a prognostic biomarker and therapeutic target for patients with CRC." 1 Circ_0075960 targets the miR-202-5p/CTNND1 axis to promote the growth and migration of endometrial carcinoma cells via regulating Wnt/beta-catenin signaling activity. hsa_circ_0075960 - Circ_0075960 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "Circ_0075960 targets the miR-202-5p/CTNND1 axis to modulate Wnt/beta-catenin signaling activity, thus contributing to the malignant development of EC." 2 Hsa_circ_0074158 regulates the endothelial barrier function in sepsis and its potential value as a biomarker. hsa_circ_0074158 hsa_circ_CTNNA1 circ_0074158 DOID:0040085 bacterial sepsis sepsis "RT-qPCR, RNA-seq" up-regulated hsa_circ_0074158 knockdown could partially reverse the LPS-induced TEER reduction and FITC-dextran extravasation elevation in sepsis. 1 Hsa_circ_0000129 drives tumor growth via sequestering miR-485-3p and upregulating SPIN1 in breast cancer. hsa_circ_0000129 hsa_circ_TMOD4 circ_0000129 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_0000129 acted as a miR-485-3p sponge molecular to mediate expression, thus promoting BC progression." 1 Circ_0007385 promotes the proliferation and inhibits the apoptosis of non-small cell lung cancer cells via miR-337-3p-dependent regulation of LMO3. hsa_circ_0007385 - Circ_0007385 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0007385 promoted the proliferation ability and inhibited the apoptosis of NSCLC cells by binding to miR-337-3p to induce LMO3 expression. 5 N6-Methyladenosine Modification of CIRCKRT17 Initiated by METTL3 Promotes Osimertinib Resistance of Lung Adenocarcinoma by EIF4A3 to Enhance YAP1 Stability. - hsa_circ_KRT17 CIRCKRT17 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "METTL3 initiated the m6A modification of circKRT17, thus promoting osimertinib resistance of LUAD by enhancing YAP1 stability through EIF4A4 recruitment." 1 CircANKRD12 Is Induced in Endothelial Cell Response to Oxidative Stress. - hsa_circ_ANKRD12 CircANKRD12 DOID:1287 cardiovascular system disease cardiovascular disease RT-qPCR up-regulated CircANKRD12 Is Induced in Endothelial Cell Response to Oxidative Stress. 1 Circular RNA hsa_circ_0051040 Promotes Hepatocellular Carcinoma Progression by Sponging miR-569 and Regulating ITGAV Expression. hsa_circ_0051040 hsa_circ_FBL - DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray up-regulated hsa_circ_0051040 promotes HCC development and progression by sponging miR-569 to increase ITGAV expression. 1 "circSMARCA5 Is an Upstream Regulator of the Expression of miR-126-3p, miR-515-5p, and Their mRNA Targets, Insulin-like Growth Factor Binding Protein 2 (IGFBP2) and NRAS Proto-Oncogene, GTPase (NRAS) in Glioblastoma." - hsa_circ_SMARCA5 circSMARCA5 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR down-regulated "circSMARCA5 Is an Upstream Regulator of the Expression of miR-126-3p, miR-515-5p, and Their mRNA Targets, Insulin-like Growth Factor Binding Protein 2 (IGFBP2) and NRAS Proto-Oncogene, GTPase (NRAS) in Glioblastoma." 3 circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. - hsa_circ_Csnk1g3 circCsnk1g3- DOID:1115 sarcoma sarcoma "RT-qPCR, RNA-seq" dysregulated "circCsnk1g3 and circAnkib1 can control the expression of interferon-related genes and pro-inflammatory factors in the sarcoma cells, thus directing immune cell recruitment into the tumor mass, and hence their activation." 1 circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. - hsa_circ_Ankib1 circAnkib1- DOID:1115 sarcoma sarcoma "RT-qPCR, RNA-seq" dysregulated "circCsnk1g3 and circAnkib1 can control the expression of interferon-related genes and pro-inflammatory factors in the sarcoma cells, thus directing immune cell recruitment into the tumor mass, and hence their activation." 1 Diagnostic value of circN4BP2L2 in type I and type II epithelial ovarian cancer. - hsa_circ_N4BP2L2 circN4BP2L2 DOID:2152 ovary epithelial cancer epithelial ovarian cancer RT-qPCR down-regulated CircN4BP2L2 might serve as a promising diagnostic biomarker for both type I and type II EOC. 2 CircRNA has_circ_0017109 promotes lung tumor progression via activation of Wnt/beta-catenin signaling due to modulating miR-671-5p/FZD4 axis. hsa_circ_0017109 hsa_circ_NID1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Elevated circ_0017109 expression promotes tumor progression of NSCLC by modulating miR-671-5p/FZD4/beta-catenin axis. 1 Myc-mediated circular RNA circMcph1/miR-370-3p/Irak2 axis is a progressive regulator in hepatic fibrosis. - hsa_circ_Mcph1 circMcph1 DOID:409 liver disease hepatic fibrosis RT-qPCR up-regulated Myc-mediated circular RNA circMcph1/miR-370-3p/Irak2 axis is a progressive regulator in hepatic fibrosis. 1 Circular RNA circLOC101928570 suppresses systemic lupus erythematosus progression by targeting the miR-150-5p/c-myb axis. - - circLOC101928570 DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR down-regulated circLOC101928570 suppresses systemic lupus erythematosus progression by targeting the miR-150-5p/c-myb axis. 1 Circ_0136474 promotes the progression of osteoarthritis by sponging mir-140-3p and upregulating MECP2. hsa_circ_0136474 - Circ_0136474 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Circ_0136474 knockdown alleviated IL-1beta-triggered CHON-001 cell damage through modulation of miR-140-3p/MECP2 axis, indicating a new target for treatment of OA." 2 Circ_0008784 activates Wnt/beta-catenin pathway to affect the proliferation and apoptosis of triple-negative breast cancer cells. hsa_circ_0008784 - Circ_0008784 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR dysregulated Circ_0008784 activates Wnt/beta-catenin pathway to affect the proliferation and apoptosis of TNBC cells. 1 CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer. - hsa_circ_PTK2 CircPTK2 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer. 4 Circular RNA circ_0114876 regulates osteoarthritis through upregulating ADAM10 via targeting miR-1227-3p. hsa_circ_0114876 - circ_0114876 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Circ_0114876 facilitated the progression in the LPS-induced OA cell model via regulating the miR-1227-3p/ADAM10 axis. 2 circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR. - hsa_circ_HIPK3 circHIPK3 DOID:114 heart disease aging associated cardiac dysfunction "RT-qPCR, RNA-seq" down-regulated "deletion of circHIPK3 led to exaggerated CM senescence and decreased cardiac function. As a scaffold, circHIPK3 enhanced the binding of E3 ubiquitin ligase beta-TrCP and HuR in the cytoplasm, leading to the ubiquitination and degradation of HuR and reduced p21 activity." 4 Circular RNA circ_0004488 Increases Cervical Cancer Paclitaxel Resistance via the miR-136/MEX3C Signaling Pathway. hsa_circ_0004488 - circ_0004488 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circ_0004488 was shown to induce CSC-like features and paclitaxel resistance through the miR-136/MEX3C axis. 1 Circular RNA expression profiles and identification of hsa_circ_0028381 as a potential biomarker of anti-neutrophil cytoplasmic antibody-associated vasculitis. hsa_circ_0028381 hsa_circ_C12orf51 - DOID:865 vasculitis anti-neutrophil cytoplasmic antibody -associated vasculitis "RT-qPCR, RNA-seq" up-regulated Hsa_circ_0028381 was implicated as a potential biomarker for AAV diagnosis and renal prognosis. 1 Circular RNA ITCH increases sorafenib-sensitivity in hepatocellular carcinoma via sequestering miR-20b-5p and modulating the downstream PTEN-PI3K/Akt pathway. - hsa_circ_ITCH circITCH DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated circITCH enhances sorafenib-sensitivity in sorafenib-resistant HCC cells via regulating the miR-20b-5p/PTEN/PI3K/Akt signaling cascade. 5 EIF4A3-induced circBRWD3 promotes tumorigenesis of breast cancer through miR-142-3p_miR-142-5p/RAC1/PAK1 signaling. - hsa_circ_BRWD3 circBRWD3 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated EIF4A3-induced circBRWD3 promotes tumorigenesis of breast cancer through miR-142-3p_miR-142-5p/RAC1/PAK1 signaling. 1 CircLDLR acts as a sponge for miR-667-5p to regulate SIRT1 expression in non-alcoholic fatty liver disease. - hsa_circ_LDLR CircLDLR DOID:80208 non-alcoholic fatty liver disease non-alcoholic fatty liver disease RT-qPCR down-regulated "CircLDLR alleviated the development of NAFLD by inducing autophagic flux while modulating the miR-667-5p/SIRT1 axis reversed its effects, suggesting that targeting circLDLR/miR-667-5p/SIRT1 axis may be a promising therapeutic strategy for NAFLD." 1 Circ_0000253 promotes the progression of osteosarcoma via the miR-1236-3p/SP1 axis. hsa_circ_0000253 - Circ_0000253 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Circ_0000253 promotes OS cell proliferation and suppresses cell apoptosis via regulating the miR-1236-3p/SP1 molecular axis. 1 Circ_0138960 contributes to lipopolysaccharide-induced periodontal ligament cell dysfunction. hsa_circ_0138960 - Circ_0138960 DOID:824 periodontitis periodontitis RT-qPCR up-regulated Circ_0138960 promoted LPS-induced dysfunction in PDLCs by targeting miR-518a-5p/HDAC6 axis. 1 The circRNA expression profile of colorectal inflammatory cancer transformation revealed potential predictive biomarkers. hsa_circ_0101338 - has_circ0101338 DOID:9256 colorectal cancer colorectal cancer RNA-seq up-regulated has_circ0101338 ahashsa_circ0022426 that could predict the malignant transformation of human colorectal inflammation into CRC and have certain diagnostic value. 1 The circRNA expression profile of colorectal inflammatory cancer transformation revealed potential predictive biomarkers. hsa_circ_0022426 - hsa_circ0022426 DOID:9256 colorectal cancer colorectal cancer RNA-seq up-regulated has_circ0101338 ahashsa_circ0022426 that could predict the malignant transformation of human colorectal inflammation into CRC and have certain diagnostic value. 1 m(6)A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation. - hsa_circ_FNDC3B circFNDC3B DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated m(6)A-modified circFNDC3B inhibited CRC stemness and metastasis via RNF41-dependent ASB6 degradation. 1 Hsa_circ_0001944 regulates apoptosis by regulating the binding of PARP1 and HuR in leukemia and malignant transformed cells induced by hydroquinone. hsa_circ_0001944 hsa_circ_TCONS_l2_00030860 circ_0001944 DOID:1240 leukemia leukemia RT-qPCR up-regulated "hsa_circ_001944 was able to dissociate HuR and PARP1 binding in HQ-TK6 cells, control PARP1 production, and ultimately alter the PARP1/H-Ras pathway." 1 Exosomal circNFIX promotes angiogenesis in ovarian cancer via miR-518a-3p/TRIM44 axis. - hsa_circ_NFIX circNFIX DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated OC-derived exosomal circNFIX promoted angiogenesis by regulating the Janus-activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) pathway via miR-518a-3p/TRIM44 axis in HUVECs. 2 The aggravate role of exosomal circRNA11:120406118|12040782 on macrophage pyroptosis through miR-30b-5p/NLRP3 axis in silica-induced lung fibrosis. - - circRNA11:120406118|12040782 DOID:850 lung disease silica-induced lung fibrosis "RT-qPCR, RNA-seq" up-regulated "Our findings suggested that exosomal circRNA11:120406118|12040782 could aggravate NLRP3-mediated macrophages pyroptosis through sponging miR-30b-5p in silicosis development, which provide an experimental basis and shed light on the early diagnosis and treatment of silicosis." 1 Hsa-circ-0052001 promotes gastric cancer cell proliferation and invasion via the MAPK pathway. hsa_circ_0052001 - circ-0052001 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Hsa-circ-0052001 functions as a tumor gene in promoting the progression of GC through MAPK pathway. 1 Circ-E-Cad encodes a protein that promotes the proliferation and migration of gastric cancer via the TGF-beta/Smad/C-E-Cad/PI3K/AKT pathway. - hsa_circ_E-Cad Circ-E-Cad DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "TGF-beta/Smad pathway could increase the expression of C-E-Cad to regulate GC cell proliferation, migration, and epithelial-mesenchymal transition by affecting PI3K/AKT signaling." 1 Gastric cancer stem cell-derived exosomes promoted tobacco smoke-triggered development of gastric cancer by inducing the expression of circ670. - - circ670 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "hsa-circRNA-000670 (circ670) was up-regulated in tissues of gastric cancer patients with smoking history, tobacco smoke-induced GCSCs, and their exosomes." 1 CircRNA circ_POSTN promotes the malignancy of glioma by regulating the miR-433-3p/SPARC axis. hsa_circ_0030018 hsa_circ_POSTN circ_POSTN DOID:0060108 brain glioma glioma RT-qPCR up-regulated circ_POSTN promotes the malignancy of glioma by regulating the miR-433-3p/SPARC axis. 5 C-Fos-activated circRPPH1 contributes to glioma stemness. - hsa_circ_RPPH1 circRPPH1 DOID:0060108 brain glioma glioma RT-qPCR up-regulated c-Fos-activated circRPPH1 contributes to glioma stemness and provides a potential target for glioma progression based on the c-FOS/circRPPH1 regulatory axis. 2 CircRalgapa1 facilitates morphine tolerance via miR-873a-5p/A20 axis in mice. - hsa_circ_Ralgapa1 CircRalgapa1 DOID:2560 morphine dependence morphine tolerance RT-qPCR down-regulated chronic morphine administration-mediated down-regulation of circRalgapa1 in the spinal cord contributes to morphine tolerance via miR-873a-5p/A20 axis in mice. Overexpression of circRalgapa1 may be a promising RNA-based therapy for morphine tolerance. 1 Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-beta2 axis. hsa_circ_0001293 - circ_0001293 DOID:1826 epilepsy epileptogenesis RT-qPCR dysregulated HsTx2 suppressed PTZ-induced epilepsy by ameliorating inflammation in astrocytes via the circ_0001293/miR-8114/TGF-beta2 axis. 1 "CircPACRGL promoted cell proliferation, migration and invasion as well as inhibited cell apoptosis in colorectal cancer via regulation of the miR-330-3p/CNBP axis." - hsa_circ_PACRGL CircPACRGL DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated circPACRGL affected tumor growth by targeting miR-330-3p/CNBP axis in CRC. 1 Circ_0001686 knockdown suppresses tumorigenesis and enhances radiosensitivity in esophagus cancer through regulating miR-876-5p/SPIN1 axis. hsa_circ_0001686 - Circ_0001686 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated Circ_0001686 contributed to the progression and radioresistance of esophagus cancer cells via regulating SPIN1 expression by targeting miR-876-5p. 1 Hsa_Circ_0134426 Attenuates the Malignant Biological Behaviors of Multiple Myeloma by Suppressing miR-146b-3p to Upregulate NDNF. hsa_circ_0134426 hsa_circ_GRB10 Circ_0134426 DOID:9538 multiple myeloma multiple myeloma RT-qPCR down-regulated Hsa_Circ_0134426 Attenuates the Malignant Biological Behaviors of Multiple Myeloma by Suppressing miR-146b-3p to Upregulate NDNF. 1 Circ_0004104 participates in the regulation of ox-LDL-induced endothelial cells injury via miR-942-5p/ROCK2 axis. hsa_circ_0004104 - Circ_0004104 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Circ_0004104 downregulation receded ox-LDL-induced injury in HUVECs through miR-942-5p and ROCK2. 2 The circHMGCS1-miR-205-5p-ErBB3 axis mediated the Sanggenon C-induced anti-proliferation effects on human prostate cancer. - hsa_circ_HMGCS1 circHMGCS1 DOID:10283 prostate cancer prostate cancer "RT-qPCR, microarray" up-regulated The circHMGCS1-miR-205-5p-ErBB3 axis mediated the Sanggenon C-induced anti-proliferation effects on human prostate cancer. 1 Comprehensive evaluation of circRNAs in cirrhotic cardiomyopathy before and after liver transplantation. - hsa_circ_ASAP1 circ-ASAP1 DOID:3978 extrinsic cardiomyopathy cirrhotic cardiomyopathy "RT-qPCR, RNA-seq" down-regulated "The qRT-PCR results showed that circ-ASAP1, circ-N4BP2L2, circ-EXOC6B were significantly downregulated (P < 0.05), which were consistent with the RNA sequencing data." 1 Comprehensive evaluation of circRNAs in cirrhotic cardiomyopathy before and after liver transplantation. - hsa_circ_N4BP2L2 circ-N4BP2L2 DOID:3978 extrinsic cardiomyopathy cirrhotic cardiomyopathy "RT-qPCR, RNA-seq" down-regulated "The qRT-PCR results showed that circ-ASAP1, circ-N4BP2L2, circ-EXOC6B were significantly downregulated (P < 0.05), which were consistent with the RNA sequencing data." 1 Comprehensive evaluation of circRNAs in cirrhotic cardiomyopathy before and after liver transplantation. - hsa_circ_EXOC6B circ-EXOC6B DOID:3978 extrinsic cardiomyopathy cirrhotic cardiomyopathy "RT-qPCR, RNA-seq" down-regulated "The qRT-PCR results showed that circ-ASAP1, circ-N4BP2L2, circ-EXOC6B were significantly downregulated (P < 0.05), which were consistent with the RNA sequencing data." 1 "Circ_0000069 contributes to the growth, metastasis and glutamine metabolism in renal cell carcinoma (RCC) via regulating miR-125a-5p-dependent SLC1A5 expression." hsa_circ_0000069 - Circ_0000069 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated Circ_0000069 knockdown inhibited the carcinogenesis of RCC by regulating miR-125a-5p/SLC1A5 axis. 1 Propofol inhibits cell apoptosis and inflammatory response in ox-LDL-induced human umbilical vein endothelial cells through the modulation of the circ_0003645/miR-149-3p/TRAF7 axis. hsa_circ_0003645 - circ_0003645 DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated Propofol inhibits cell apoptosis and inflammatory response in ox-LDL-induced human umbilical vein endothelial cells through the modulation of the circ_0003645/miR-149-3p/TRAF7 axis. 3 Circular RNA hsa_circ_0007990 as a blood biomarker for unruptured intracranial aneurysm with aneurysm wall enhancement. hsa_circ_0007990 hsa_circ_PGAP3 - DOID:10941 intracranial aneurysm intracranial aneurysms microarray up-regulated hsa_circ_0007990 as a blood biomarker for unruptured intracranial aneurysm with aneurysm wall enhancement. 1 Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome. - rno_circ_Kcnk9 circKcnk9 DOID:9778 irritable bowel syndrome Irritable bowel syndrome RT-qPCR up-regulated "early life stress induces increased expression of circKcnk9 in the CA1 of IBS-like rats. Increased circKcnk9 expression regulates synaptic transmission and enhances LTP, leading to visceral hypersensitivity and anxiety in IBS-like rats. The underlying circKcnk9 signaling pathway is miR124-3p/EZH2. Increased circKcnk9 reinforces its sponging of miR124-3p and strongly suppresses miR124-3p activity, resulting in increased expression of the target gene EZH2." 2 Hsa_circ_0019054 up-regulates HIF1A through sequestering miR-340-5p to promote the tumorigenesis of intrahepatic cholangiocarcinoma. hsa_circ_0019054 hsa_circ_ATAD1 circ_0019054 DOID:4928 intrahepatic cholangiocarcinoma intrahepatic cholangiocarcinoma RT-qPCR up-regulated "Hsa_circ_0,019,054 deficiency could attenuate the proliferation and glycolysis of ICC cells via miR-340-5 p/HIF1A axis." 1 Exosomal miR-628-5p from M1 polarized macrophages hinders m6A modification of circFUT8 to suppress hepatocellular carcinoma progression. - hsa_circ_FUT8 circFUT8 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "M1 macrophages-derived exosomal miR-628-5p inhibited the m6A modification of circFUT8, inhibiting HCC development." 2 Exosome-transmitted circ_002136 promotes hepatocellular carcinoma progression by miR-19a-3p/RAB1A pathway. - - circ_002136 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Exosome-transmitted circ_002136 promotes hepatocellular carcinoma progression by miR-19a-3p/RAB1A pathway. 1 Circklhl2 Knockdown Alleviates Sepsis-Induced Acute Lung Injury by Regulating Mir-29b-3p Mediated Rock1 Expression down-Regulation. - hsa_circ_Klhl2 circKlhl2 DOID:850 lung disease Acute lung injury RT-qPCR down-regulated CircKlhl2 expedited the sepsis-induced ALI by adjusting miR-29b-3p/ROCK1 axis. 1 Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p. - ssc_circ_CREBBP circ-CREBBP DOID:48 male reproductive system disease male reproductive diseases "RT-qPCR, RNA-seq" down-regulated "The above results suggested that circ-CREBBP indirectly regulated the expression of MCL1, CREBBP, and CERB1 through miR-10384 and miR-143-3p." 1 Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p. - ssc_circ_EP300 circ-EP300 DOID:48 male reproductive system disease male reproductive diseases "RT-qPCR, RNA-seq" up-regulated "Furthermore, the results showed that circ-CREBBP, circ-EP300, circ-KLHL3, circ-SUGCT, and circ-SLC5A10 were significantly differentially expressed between the two groups (Fig. 3e), and the expression trends in the two groups were consistent with the sequencing results." 1 Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p. - ssc_circ_KLHL3 circ-KLHL3 DOID:48 male reproductive system disease male reproductive diseases "RT-qPCR, RNA-seq" down-regulated "Furthermore, the results showed that circ-CREBBP, circ-EP300, circ-KLHL3, circ-SUGCT, and circ-SLC5A10 were significantly differentially expressed between the two groups (Fig. 3e), and the expression trends in the two groups were consistent with the sequencing results." 1 Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p. - ssc_circ_SUGCT circ-SUGCT DOID:48 male reproductive system disease male reproductive diseases "RT-qPCR, RNA-seq" down-regulated "Furthermore, the results showed that circ-CREBBP, circ-EP300, circ-KLHL3, circ-SUGCT, and circ-SLC5A10 were significantly differentially expressed between the two groups (Fig. 3e), and the expression trends in the two groups were consistent with the sequencing results." 1 Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p. - ssc_circ_PTGES3 circ-PTGES3 DOID:48 male reproductive system disease male reproductive diseases "RT-qPCR, RNA-seq" down-regulated "Furthermore, the results showed that circ-CREBBP, circ-EP300, circ-KLHL3, circ-SUGCT, and circ-SLC5A10 were significantly differentially expressed between the two groups (Fig. 3e), and the expression trends in the two groups were consistent with the sequencing results." 1 Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p. - ssc_circ_SLC5A10 circ-SLC5A10 DOID:48 male reproductive system disease male reproductive diseases "RT-qPCR, RNA-seq" up-regulated "Furthermore, the results showed that circ-CREBBP, circ-EP300, circ-KLHL3, circ-SUGCT, and circ-SLC5A10 were significantly differentially expressed between the two groups (Fig. 3e), and the expression trends in the two groups were consistent with the sequencing results." 1 Role of hsa_circ_0000280 in regulating vascular smooth muscle cell function and attenuating neointimal hyperplasia via ELAVL1. hsa_circ_0000280 hsa_circ_HPS5 circ_0000280 DOID:3393 coronary artery disease coronary heart disease RNA-seq dysregulated hsa_circ_0000280 facilitates the regulation of ELAVL1 on CDKN1A mRNA to inhibit NIH. 1 Circ_0021573 acts as a competing endogenous RNA to promote the malignant phenotypes of human ovarian cancer cells. hsa_circ_0021573 - Circ_0021573 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated circ_0021573 might promote the malignant phenotypes of ovarian cancer cells by functioning as a ceRNA for miR-936 to induce CUL4B. 1 Hsa_circ_0000119 promoted ovarian cancer development via enhancing the methylation of CDH13 by sponging miR-142-5p. hsa_circ_0000119 hsa_circ_MAN1A2 circ_0000119 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated hsa_circ_0000119 facilitated ovarian cancer development through increasing CDH13 expression via promoting DNMT1 expression by sponging miR-142-5p. 1 CircSCN8A suppresses malignant progression and induces ferroptosis in non-small cell lung cancer by regulating miR-1290/ACSL4 axis. hsa_circ_0026337 hsa_circ_SCN8A CircSCN8A DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated circSCN8A represses cell proliferation and metastasis in NSCLC by regulating the miR-1290/ACSL4 axis to induce ferroptosis. 1 CircLPAR3 knockdown suppresses esophageal squamous cell carcinoma cell oncogenic phenotypes and Warburg effect through miR-873-5p/LDHA axis. - hsa_circ_LPAR3 CircLPAR3 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "CircLPAR3 knockdown suppressed ESCC cell growth, metastasis, and Warburg effect by miR-873-5p/LDHA axis, implying a promising molecular target for ESCC therapy." 2 Depletion of circPDSS1 inhibits ITGA11 production to confer cisplatin sensitivity through miR-515-5p in gastric cancer. - hsa_circ_PDSS1 circPDSS1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Depletion of circPDSS1 inhibits ITGA11 production to confer cisplatin sensitivity through miR-515-5p in gastric cancer. 2 Profiling and Bioinformatics Analyses of Differential Circular RNA Expression in Glioblastoma Multiforme Cells Under Hypoxia. hsa_circ_0000745 hsa_circ_SPECC1 - DOID:3073 brain glioblastoma multiforme glioblastoma "RT-qPCR, RNA-seq" up-regulated "Inhibition of hsa_circ_0000745 inhibited GBM cells proliferation, migration, and invasion." 1 circPLIN2 promotes clear cell renal cell carcinoma progression by binding IGF2BP proteins and miR-199a-3p. hsa_circ_0086457 hsa_circ_PLIN2 circPLIN2 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, RNA-seq" up-regulated circPLIN2 promotes clear cell renal cell carcinoma progression by binding IGF2BP proteins and miR-199a-3p. 1 "CircNFIX stimulates the proliferation, invasion, and stemness properties of ovarian cancer cells by enhancing SH3RF3 mRNA stability via binding LIN28B." - hsa_circ_NFIX CircNFIX DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "CircNFIX improved the mRNA stability and translation of SH3RF3 via recruiting LIN28B, thus promoting the proliferation, invasion, and stemness properties of OC cells in vitro." 2 Circ_0022340 promotes colorectal cancer progression via HNRNPC/EBF1/SYT7 or miR-382-5p/ELK1 axis. hsa_circ_0022340 - Circ_0022340 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0022340 promoted colorectal cancer progression via recruiting HNRNPC to stabilize EBF1 mRNA and thereby activated SYT7 or miR-382-5p/ELK1 axis. 1 "Expression analysis of hsa_circ_0020397, hsa_circ_0005986, hsa_circ_0003028, and hsa_circ_0006990 in renal cell carcinoma." hsa_circ_0020397 hsa_circ_DOCK1 circ_0020397 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR down-regulated "the expression of hsa_circ_0020397, hsa_circ_0005986, and hsa_circ_0006990 was downregulated in RCC tissues." 1 "Expression analysis of hsa_circ_0020397, hsa_circ_0005986, hsa_circ_0003028, and hsa_circ_0006990 in renal cell carcinoma." hsa_circ_0005986 hsa_circ_PRDM2 - DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR down-regulated "the expression of hsa_circ_0020397, hsa_circ_0005986, and hsa_circ_0006990 was downregulated in RCC tissues." 1 "Expression analysis of hsa_circ_0020397, hsa_circ_0005986, hsa_circ_0003028, and hsa_circ_0006990 in renal cell carcinoma." hsa_circ_0006990 hsa_circ_VAPA - DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR down-regulated "the expression of hsa_circ_0020397, hsa_circ_0005986, and hsa_circ_0006990 was downregulated in RCC tissues." 1 CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease. - hsa_circ_ZXDC CircZXDC DOID:13099 Moyamoya disease moyamoya RT-qPCR up-regulated Our findings provide insight into the pathophysiological mechanisms of MMD and indicate that the circZXDC-miR-125a-3p-ABCC6 axis plays a pivotal role in the progression of MMD. 1 circRNF10 Regulates Tumorigenic Properties and Natural Killer Cell-Mediated Cytotoxicity against Breast Cancer through the miR-934/PTEN/PI3k-Akt Axis. - hsa_circ_RNF10 circRNF10 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated These findings reveal that circRNF10 functions as a novel anti-oncogene in BC via sponging miR-934 and suppressing the PI3K/Akt/MICA pathway. 3 CircSMARCC1 and CircLRBA are potential biomarkers in forensic postmortem diagnosis of acute myocardial infarction. - hsa_circ_SMARCC1 CircSMARCC1 DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR up-regulated circSMARCC1 and circLRBA are potential biomarkers for postmortem diagnosis of AMI. 1 CircSMARCC1 and CircLRBA are potential biomarkers in forensic postmortem diagnosis of acute myocardial infarction. - hsa_circ_LRBA circLRBA DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR down-regulated circSMARCC1 and circLRBA are potential biomarkers for postmortem diagnosis of AMI. 1 CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway. - hsa_circ_SETD3 CircSETD3 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircSETD3/FXR1/ECT2 axis plays a critical role in the acquired resistance to gefitinib in NSCLC. Our results highlight the potential of circSETD3 as a biomarker and therapeutic target for NSCLC patients with acquired gefitinib resistance. 3 Hypoxia-pretreated ADSC-derived exosome-embedded hydrogels promote angiogenesis and accelerate diabetic wound healing. mmu_circ_0001100 mmu_circ_Snhg11 circ-Snhg11 DOID:9351 diabetes mellitus diabetic wound healing "RT-qPCR, RNA-seq" up-regulated "Furthermore, circ-Snhg11-modified ADSC-Exos increased the migratory, proliferative and blood vessel regeneration potential of vascular endothelial cells (ECs). In addition, overexpression (OE) of NFE2L2-HIF1alpha or inhibition of miR-144-3p-both of which are members of the miR-144-3p/NFE2L2/HIF1alpha pathway downstream of circ-Snhg11-reversed the therapeutic effects of circ-Snhg11." 2 circPHF16 suppresses prostate cancer metastasis via modulating miR-581/RNF128/Wnt/beta-catenin pathway. - hsa_circ_PHF16 circPHF16 DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated "In total, our findings revealed that circPHF16 suppressed prostate cancer metastasis through the circPHF16/miR-581/Wnt/beta-catenin pathways." 1 Gene Expression Network and Circ_0008012 Promote Progression in MLL/AF4 Positive Acute Lymphoblastic Leukemia. hsa_circ_0008012 - Circ_0008012 DOID:9952 acute lymphoblastic leukemia acute lymphoblastic leukemia RT-qPCR up-regulated "We found that circ_0008012 was upregulated in MLL/AF4 ALL cells and regulated cell proliferation and apoptosis. Further computed simulation and RIP showed that IKKbeta was the strongest protein in the NF-¦ŞB pathway binding with circ_0008012. As a result, possible regulation of circ_0008012 is suggested by binding IKKbeta in the IKKalpha:IKKbeta:IKKgamma compound, which then phosphorylates I¦ŞB and activates NF- ¦ŞB:p65:p300 compound in cell nucleus, thereby leading to leukemia." 1 CircCDR1as mediates PM(2.5)-induced lung cancer progression by binding to SRSF1. - - CircCDR1as DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "CircCDR1as also affected C-myc and cyclin D1 expression by regulating SRSF1 and affecting the wnt/beta-catenin signalling pathway, ultimately promoting malignant behavior and inhibiting the apoptosis of lung cancer cells, thereby causing PM2.5-induced lung cancer development." 1 Extracellular Vesicle-Packaged circATP2B4 Mediates M2 Macrophage Polarization via miR-532-3p/SREBF1 Axis to Promote Epithelial Ovarian Cancer Metastasis. hsa_circ_0000173 hsa_circ_ATP2B4 circATP2B4 DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, RNA-seq" up-regulated "Collectively, these data indicate that circATP2B4-containing EVs generated by EOC cells promoted M2 macrophages polarization and malignant behaviors of EOC cells." 1 Reconstruction and analysis of circRNA-miRNA-mRNA network in the pathology of lung cancer. hsa_circ_0001806 hsa_circ_CSPP1 - DOID:1324 lung cancer lung cancer microarray down-regulated "To more specifically study which circRNAs and their target genes (mRNAs) regulated via the ceRNA network are related to the prognosis of LC, this study built the circRNA-miRNA-mRNA regulatory network, and screened out the ceRNA regulatory axis that may be mediated by has_circ_0001806-miR-3178-FXYD1 and has_circ_0031968-miR-4270-SEMA5A." 1 Reconstruction and analysis of circRNA-miRNA-mRNA network in the pathology of lung cancer. hsa_circ_0031968 hsa_circ_FERMT2 - DOID:1324 lung cancer lung cancer microarray down-regulated "To more specifically study which circRNAs and their target genes (mRNAs) regulated via the ceRNA network are related to the prognosis of LC, this study built the circRNA-miRNA-mRNA regulatory network, and screened out the ceRNA regulatory axis that may be mediated by has_circ_0001806-miR-3178-FXYD1 and has_circ_0031968-miR-4270-SEMA5A." 2 Circ_0001777 Affects Triple-negative Breast Cancer Progression Through the miR-95-3p/AKAP12 Axis. hsa_circ_0001777 hsa_circ_ESYT2 circ_0001777 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "Overexpression of circ_0001777 decreased proliferation, migration, and invasion of TNBC cells by regulating the miR-95-3p/AKAP12 axis, suggesting that circ_0001777/miR-95-3p/AKAP12 axis may be a potential regulatory mechanism for the treatment of TNBC." 1 Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases. hsa_circ_0001165 hsa_circ_NCOA3 - DOID:824 periodontitis F. nucleatum-associated disease "RT-qPCR, RNA-seq" down-regulated "In which, AKT2 is controlled by hsa_circ_0078617, hsa_circ_0069227, hsa_circ_0084089, lncRNA NUP210, lncRNA ABCB9, lncRNA DIXDC1, lncRNA ATXN1 and lncRNA XLOC_237387 through miR-150-5p; hsa_circ_0001165, hsa_circ_0008460, hsa_circ_0001118, lncRNA XLOC_237387 and lncRNA ATXN1 were identified as the ceRNAs of hsa-miR-146a-3p and thereby indirectly modulating the expression of MITF." 1 Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases. hsa_circ_0008460 hsa_circ_WHSC1 - DOID:824 periodontitis F. nucleatum-associated disease "RT-qPCR, RNA-seq" down-regulated "In which, AKT2 is controlled by hsa_circ_0078617, hsa_circ_0069227, hsa_circ_0084089, lncRNA NUP210, lncRNA ABCB9, lncRNA DIXDC1, lncRNA ATXN1 and lncRNA XLOC_237387 through miR-150-5p; hsa_circ_0001165, hsa_circ_0008460, hsa_circ_0001118, lncRNA XLOC_237387 and lncRNA ATXN1 were identified as the ceRNAs of hsa-miR-146a-3p and thereby indirectly modulating the expression of MITF." 1 Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases. hsa_circ_0001118 hsa_circ_NDUFA10 - DOID:824 periodontitis F. nucleatum-associated disease "RT-qPCR, RNA-seq" down-regulated "In which, AKT2 is controlled by hsa_circ_0078617, hsa_circ_0069227, hsa_circ_0084089, lncRNA NUP210, lncRNA ABCB9, lncRNA DIXDC1, lncRNA ATXN1 and lncRNA XLOC_237387 through miR-150-5p; hsa_circ_0001165, hsa_circ_0008460, hsa_circ_0001118, lncRNA XLOC_237387 and lncRNA ATXN1 were identified as the ceRNAs of hsa-miR-146a-3p and thereby indirectly modulating the expression of MITF." 1 Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases. hsa_circ_0078617 hsa_circ_MAP3K4 - DOID:824 periodontitis F. nucleatum-associated disease "RT-qPCR, RNA-seq" down-regulated "In which, AKT2 is controlled by hsa_circ_0078617, hsa_circ_0069227, hsa_circ_0084089, lncRNA NUP210, lncRNA ABCB9, lncRNA DIXDC1, lncRNA ATXN1 and lncRNA XLOC_237387 through miR-150-5p; hsa_circ_0001165, hsa_circ_0008460, hsa_circ_0001118, lncRNA XLOC_237387 and lncRNA ATXN1 were identified as the ceRNAs of hsa-miR-146a-3p and thereby indirectly modulating the expression of MITF." 1 Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases. hsa_circ_0084089 hsa_circ_KAT6A - DOID:824 periodontitis F. nucleatum-associated disease "RT-qPCR, RNA-seq" down-regulated "In which, AKT2 is controlled by hsa_circ_0078617, hsa_circ_0069227, hsa_circ_0084089, lncRNA NUP210, lncRNA ABCB9, lncRNA DIXDC1, lncRNA ATXN1 and lncRNA XLOC_237387 through miR-150-5p; hsa_circ_0001165, hsa_circ_0008460, hsa_circ_0001118, lncRNA XLOC_237387 and lncRNA ATXN1 were identified as the ceRNAs of hsa-miR-146a-3p and thereby indirectly modulating the expression of MITF." 1 Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases. hsa_circ_0069227 hsa_circ_FBXL5 - DOID:824 periodontitis F. nucleatum-associated disease "RT-qPCR, RNA-seq" down-regulated "In which, AKT2 is controlled by hsa_circ_0078617, hsa_circ_0069227, hsa_circ_0084089, lncRNA NUP210, lncRNA ABCB9, lncRNA DIXDC1, lncRNA ATXN1 and lncRNA XLOC_237387 through miR-150-5p; hsa_circ_0001165, hsa_circ_0008460, hsa_circ_0001118, lncRNA XLOC_237387 and lncRNA ATXN1 were identified as the ceRNAs of hsa-miR-146a-3p and thereby indirectly modulating the expression of MITF." 1 circCYP24A1 facilitates esophageal squamous cell carcinoma progression through binding PKM2 to regulate NF-kappaB-induced CCL5 secretion. - hsa_circ_CYP24A1 circCYP24A1 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "Up-regulated circCYP24A1 could activate NF-kB pathway by binding PKM2, which promotes the secretion of CCL5 and accelerate malignant progression of ESCC." 1 circ-BPTF serves as a miR-486-5p sponge to regulate CEMIP and promotes hypoxic pulmonary arterial smooth muscle cell proliferation in COPD. hsa_circ_0045462 hsa_circ_BPTF circ-BPTF DOID:3083 chronic obstructive pulmonary disease chronic obstructive pulmonary disease "RT-qPCR, microarray" up-regulated "Overall, our study shows that circ-BPTF serves as a miR-486-5p sponge to regulate CEMIP and promote hypoxic PASMC proliferation in pulmonary vascular remodelling in COPD." 1 Circular RNAs expression profiles and bioinformatics analysis in bronchopulmonary dysplasia. hsa_circ_0007054 hsa_circ_TMEM50A - DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, microarray" up-regulated "As a result, the ceRNA network was constructed based on three upregulated DEcircRNAs validated by qRT-PCR (hsa_circ_0007054, hsa_circ_0057950, and hsa_circ_0120151)." 1 Circular RNAs expression profiles and bioinformatics analysis in bronchopulmonary dysplasia. hsa_circ_0120151 hsa_circ_PRKCE - DOID:11650 bronchopulmonary dysplasia bronchopulmonary dysplasia "RT-qPCR, microarray" up-regulated "As a result, the ceRNA network was constructed based on three upregulated DEcircRNAs validated by qRT-PCR (hsa_circ_0007054, hsa_circ_0057950, and hsa_circ_0120151)." 1 Hsa_circ_0026344 suppresses gastric cancer progression via modulating the miR-1290/FBP2 axis. hsa_circ_0026344 hsa_circ_ACVRL1 circ_0026344 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "In conclusion, circ_0026344 inhibited GC cell proliferation via the miR-1290/FBP2 axis, which might provide a new therapeutic target for GC patients." 2 Circ_0000052/miR-382-3p axis induces PD-L1 expression and regulates cell proliferation and immune evasion in head and neck squamous cell carcinoma. hsa_circ_0000052 hsa_circ_EIF2C1 circ_0000052 DOID:5520 head and neck squamous cell carcinoma head and neck squamous cell carcinoma RT-qPCR up-regulated "Our data demonstrate that circ_0000052 is oncogenic, and the circ_0000052/miR-382-3p/PD-L1 axis is critical in HNSCC progression." 1 circTMEM181 upregulates ARHGAP29 to inhibit hepatocellular carcinoma migration and invasion by sponging miR-519a-5p. - hsa_circ_TMEM181 circTMEM181 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "These data provide the first evidence of clinical significance and function of circTMEM181, and suggest the circTMEM181/miR-519a-5p/ARHGAP29 axis in HCC development." 2 Circ-CCS regulates oxaliplatin resistance via targeting miR-874-3p/HK2 axis in colorectal cancer. - hsa_circ_CCS Circ-CCS DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "The results also showed that HK2 could regulate the development of CRC. In mechanism, circ-CCS targeted miR-874-3p to control HK2. In addition, circ-CCS knock-down also attenuated tumor growth in mice." 1 circEZH2(E2) (/E3) is a dual suppressor of miR363/miR708 to promote EZH2 expression and prostate cancer progression. hsa_circ_0006357 hsa_circ_EZH2 circEZH2(E2) DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "These findings show a novel autoenhancing EZH2_circEZH2-miR363/miR708_EZH2 regulatory loop, by which circEZH2 plays important roles in PCa tumorigenesis and progression by upregulating EZH2, and may have potential diagnostic, prognostic, and therapeutic uses in PCa management." 1 IGF2BP2-induced circRUNX1 facilitates the growth and metastasis of esophageal squamous cell carcinoma through miR-449b-5p/FOXP3 axis. hsa_circ_0002360 hsa_circ_RUNX1 circRUNX1 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "IGF2BP2 mediated circRUNX1 functions as an oncogenic factor to facilitate ESCC progression through the miR-449b-5p/FOXP3 axis, implying that circRUNX1 has the potential to be a promising diagnostic marker and therapeutic target for ESCC patients." 1 Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage. hsa_circ_0001707 hsa_circ_ABCA13 - DOID:6713 cerebrovascular disease intracerebral hemorrhage "RT-qPCR, RNA-seq" up-regulated "The five upregulated circRNAs in ICH were hsa_circ_0001707, hsa_circ_0091669, hsa_circ_0005505, hsa_circ_0001481 and hsa_circ_0027725; the 4 downregulated circRNAs in ICH were hsa_circ_0000914 and three novel circRNAs that we named according to their host genes, circCHST12 (host gene_HST12), circERBB2 and circGLTSCR1 (host gene_LTSCR1)." 1 Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage. hsa_circ_0091669 hsa_circ_AFF2 - DOID:6713 cerebrovascular disease intracerebral hemorrhage RNA-seq up-regulated "The five upregulated circRNAs in ICH were hsa_circ_0001707, hsa_circ_0091669, hsa_circ_0005505, hsa_circ_0001481 and hsa_circ_0027725; the 4 downregulated circRNAs in ICH were hsa_circ_0000914 and three novel circRNAs that we named according to their host genes, circCHST12 (host gene_HST12), circERBB2 and circGLTSCR1 (host gene_LTSCR1)." 1 Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage. hsa_circ_0005505 hsa_circ_IRAK3 - DOID:6713 cerebrovascular disease intracerebral hemorrhage "RT-qPCR, RNA-seq" up-regulated "The five upregulated circRNAs in ICH were hsa_circ_0001707, hsa_circ_0091669, hsa_circ_0005505, hsa_circ_0001481 and hsa_circ_0027725; the 4 downregulated circRNAs in ICH were hsa_circ_0000914 and three novel circRNAs that we named according to their host genes, circCHST12 (host gene_HST12), circERBB2 and circGLTSCR1 (host gene_LTSCR1)." 1 Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage. hsa_circ_0001481 hsa_circ_EMB - DOID:6713 cerebrovascular disease intracerebral hemorrhage RNA-seq up-regulated "The five upregulated circRNAs in ICH were hsa_circ_0001707, hsa_circ_0091669, hsa_circ_0005505, hsa_circ_0001481 and hsa_circ_0027725; the 4 downregulated circRNAs in ICH were hsa_circ_0000914 and three novel circRNAs that we named according to their host genes, circCHST12 (host gene_HST12), circERBB2 and circGLTSCR1 (host gene_LTSCR1)." 1 Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage. hsa_circ_0027725 hsa_circ_PLXNC1 - DOID:6713 cerebrovascular disease intracerebral hemorrhage "RT-qPCR, RNA-seq" up-regulated "The five upregulated circRNAs in ICH were hsa_circ_0001707, hsa_circ_0091669, hsa_circ_0005505, hsa_circ_0001481 and hsa_circ_0027725; the 4 downregulated circRNAs in ICH were hsa_circ_0000914 and three novel circRNAs that we named according to their host genes, circCHST12 (host gene_HST12), circERBB2 and circGLTSCR1 (host gene_LTSCR1)." 1 Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage. hsa_circ_0000914 hsa_circ_FKBP8 - DOID:6713 cerebrovascular disease intracerebral hemorrhage RNA-seq down-regulated "The five upregulated circRNAs in ICH were hsa_circ_0001707, hsa_circ_0091669, hsa_circ_0005505, hsa_circ_0001481 and hsa_circ_0027725; the 4 downregulated circRNAs in ICH were hsa_circ_0000914 and three novel circRNAs that we named according to their host genes, circCHST12 (host gene_HST12), circERBB2 and circGLTSCR1 (host gene_LTSCR1)." 1 Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage. - hsa_circ_GLTSCR1 circGLTSCR1 DOID:6713 cerebrovascular disease intracerebral hemorrhage RNA-seq down-regulated "The five upregulated circRNAs in ICH were hsa_circ_0001707, hsa_circ_0091669, hsa_circ_0005505, hsa_circ_0001481 and hsa_circ_0027725; the 4 downregulated circRNAs in ICH were hsa_circ_0000914 and three novel circRNAs that we named according to their host genes, circCHST12 (host gene_HST12), circERBB2 and circGLTSCR1 (host gene_LTSCR1)." 1 Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage. - hsa_circ_ERBB2 circERBB2 DOID:6713 cerebrovascular disease intracerebral hemorrhage "RT-qPCR, RNA-seq" down-regulated "The five upregulated circRNAs in ICH were hsa_circ_0001707, hsa_circ_0091669, hsa_circ_0005505, hsa_circ_0001481 and hsa_circ_0027725; the 4 downregulated circRNAs in ICH were hsa_circ_0000914 and three novel circRNAs that we named according to their host genes, circCHST12 (host gene_HST12), circERBB2 and circGLTSCR1 (host gene_LTSCR1)." 1 Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage. - hsa_circ_CHST12 circCHST12 DOID:6713 cerebrovascular disease intracerebral hemorrhage "RT-qPCR, RNA-seq" down-regulated "The five upregulated circRNAs in ICH were hsa_circ_0001707, hsa_circ_0091669, hsa_circ_0005505, hsa_circ_0001481 and hsa_circ_0027725; the 4 downregulated circRNAs in ICH were hsa_circ_0000914 and three novel circRNAs that we named according to their host genes, circCHST12 (host gene_HST12), circERBB2 and circGLTSCR1 (host gene_LTSCR1)." 1 Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS. - - circ_2979 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome "RT-qPCR, microarray" up-regulated "Among them, circ_2979, circ_5438 and circ_4557 were upregulated, and circ_2066 and circ_5431 were downregulated." 1 Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS. - - circ_5438 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome "RT-qPCR, microarray" up-regulated "Among them, circ_2979, circ_5438 and circ_4557 were upregulated, and circ_2066 and circ_5431 were downregulated." 1 Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS. - - circ_4557 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome "RT-qPCR, microarray" up-regulated "Among them, circ_2979, circ_5438 and circ_4557 were upregulated, and circ_2066 and circ_5431 were downregulated." 1 Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS. - - circ_2066 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome "RT-qPCR, microarray" down-regulated "Among them, circ_2979, circ_5438 and circ_4557 were upregulated, and circ_2066 and circ_5431 were downregulated." 1 Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS. - - circ_5431 DOID:11394 adult respiratory distress syndrome acute respiratory distress syndrome microarray down-regulated "Among them, circ_2979, circ_5438 and circ_4557 were upregulated, and circ_2066 and circ_5431 were downregulated." 1 Exosome-mediated circTTLL5 transfer promotes hepatocellular carcinoma malignant progression through miR-136-5p/KIAA1522 axis. hsa_circ_0032704 hsa_circ_TTLL5 circTTLL5 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Exosomal circTTLL5 promoted HCC progression through miR-136-5p/KIAA1522 axis, suggesting that blockage of the exosome-mediated transfer of circTTLL5 might be a therapeutic target for HCC." 2 Circular RNA hsa_circ_0004689 (circSWT1) promotes NSCLC progression via the miR-370-3p/SNAIL axis by inducing cell epithelial-mesenchymal transition (EMT). hsa_circ_0004689 hsa_circ_SWT1 circSWT1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircSWT1 promoted the invasion, migration, and EMT of NSCLC. CircSWT1 could serve as a potential biomarker and a potential therapeutic target for NSCLC." 1 CircRNA PDE3B regulates tumorigenicity via the miR-136-5p/MAP3K2 axis of esophageal squamous cell carcinoma. hsa_circ_0000277 hsa_circ_PDE3B - DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "In conclusion, circ_PDE3B acted as oncogenic circRNA in ESCC and accelerated ESCC progression by adsorption of miR-136-5p and activation of MAP3K2, supporting circ_PDE3B as a potential therapeutic target for ESCC." 3 Urinary exosomal hsa_circ_0001250 as a novel diagnostic biomarker of idiopathic membranous nephropathy. hsa_circ_0001250 - - DOID:2590 familial nephrotic syndrome adult nephrotic syndrome RNA-seq up-regulated We revealed the expression and functional profile of differentially expressed urinary exosomal circRNAs of IMN patients. Urinary exosomal hsa_circ_0001250 was tested as a potential biomarker of IMN and a predicted circRNA-miRNA-mRNA network was constructed. 1 CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug. hsa_circ_0002286 hsa_circ_NTNG1 CircNTNG1 DOID:4450 renal cell carcinoma renal cell carcinoma "RT-qPCR, microarray" down-regulated "Based on the experimental data, in RCC, circNTNG1/miR-19b-3p/HOXA5 axis can regulate the epigenetic silencing of Slug, thus interfering EMT and metastasis of RCC." 1 "Circ_0000284 upregulates RHPN2 to facilitate pancreatic cancer proliferation, metastasis, and angiogenesis through sponging miR-1179." hsa_circ_0000284 hsa_circ_HIPK3 Circ_0000284 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "To sum up, our data confirmed that circ_0000284 facilitated PC malignant progression depending on the regulation of miR-1179/RHPN2 axis, suggesting that circ_0000284 might be a potential target for PC treatment." 2 Comprehensive Analysis of Circular RNA Expression Profiles in Gefitinib-Resistant Lung Adenocarcinoma Patients. hsa_circ_0030591 hsa_circ_ABCC4 - DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "Our study provides valuable data on circRNAs expression profiles detected in liquid biopsy for LUAD patients with acquired gefitinib resistance, and we validate that upregulations of hsa_circ_0030591 and hsa_circ_0040348 may play key roles in EGFR-TKI resistance and thus serving as candidates for biomarker." 1 Comprehensive Analysis of Circular RNA Expression Profiles in Gefitinib-Resistant Lung Adenocarcinoma Patients. hsa_circ_0040348 hsa_circ_PHLPP2 - DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "Our study provides valuable data on circRNAs expression profiles detected in liquid biopsy for LUAD patients with acquired gefitinib resistance, and we validate that upregulations of hsa_circ_0030591 and hsa_circ_0040348 may play key roles in EGFR-TKI resistance and thus serving as candidates for biomarker." 1 Bone marrow stromal cell-derived exosomal circular RNA improves diabetic foot ulcer wound healing by activating the nuclear factor erythroid 2-related factor 2 pathway and inhibiting ferroptosis. - hsa_circ_ITCH circ-ITCH DOID:10881 "hand, foot and mouth disease" diabetic foot ulcer RT-qPCR down-regulated "Exosomal circ-ITCH from BMSCs inhibited ferroptosis and improved the angiogenesis of HUVECs through activation of the Nrf2 signalling pathway by recruiting TAF15 protein, ultimately accelerating the wound healing process in DFU." 1 CircSTK39 suppresses the proliferation and invasion of bladder cancer by regulating the miR-135a-5p/NR3C2-mediated epithelial-mesenchymal transition signaling pathway. hsa_circ_0001079 hsa_circ_STK39 CircSTK39 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "In conclusion, our results revealed that circSTK39 inhibited EMT of BCa cells through the miR-135a-5p/NR3C2 axis and may provide promising biomarkers for the diagnosis or prospective therapeutic targets for BCa." 1 Circ_0058608 contributes to the progression and taxol resistance of non-small cell lung cancer by sponging miR-1299 to upregulate GBP1. hsa_circ_0058608 hsa_circ_SP140L Circ_0058608 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0058608 promoted the progression and taxol resistance of NSCLC by regulating the miR-1299/GBP1 axis. 1 CircPIM3 regulates taxol resistance in non-small cell lung cancer via miR-338-3p/TNFAIP8 axis. - hsa_circ_PIM3 CircPIM3 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated CircPIM3 and TNFAIP8 were upregulated in Tax-resistant NSCLC tissue and cell samples. 1 Circ-ABCC4 contributes to prostate cancer progression and radioresistance by mediating miR-1253/SOX4 cascade. - hsa_circ_ABCC Circ-ABCC4 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Circ-ABCC4 could enhance SOX4 abundance by absorbing miR-1253. Circ-ABCC4 exerted a pro-tumor activity by facilitating PCa cell viability, proliferation, invasion, and radioresistance and suppressing apoptosis." 1 Hsa_circ_0007380 silencing restrains the growth and enhances radiosensitivity in esophagus cancer by miR-644a/Spindlin 1 axis. hsa_circ_0007380 hsa_circ_NSUN2 circ_0007380 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "Hsa_circ_0007380 silencing impedes cell growth and reinforces radiosensitivity in esophagus cancer by miR-644a/SPIN1 axis, suggesting a promising therapeutic target for esophagus cancer combined treatment." 1 The hsa_circ_0039857/miR-338-3p/RAB32 axis promotes the malignant progression of colorectal cancer. hsa_circ_0039857 hsa_circ_RANBP10 circ_0039857 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "This study demonstrated that circ_0039857 knockdown suppressed CRC malignant progression through miR-338-3p/RAB32 axis. Most importantly, this will help us to better understand the circRNA network in CRC, and may find potential biomarkers and targets for CRC clinical treatment." 1 Increased expression of miR-194-5p through the circPVRL3/miR-194-5p/SOCS2 axis promotes proliferation and metastasis in pancreatic ductal adenocarcinoma by activating the PI3K/AKT signaling pathway. hsa_circ_0004639 hsa_circ_PVRL3 circPVRL3 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR down-regulated "Our findings indicated that an increase of miR-194-5p caused by circPVRL3 downregulation stimulates the PI3K/AKT signaling pathway to promote PDAC progression via the circPVRL3/miR-194-5p/SOCS2 axis, which suggests that the circPVRL3/miR-194-5p/SOCS2 axis may be a potential therapeutic target for PDAC patients." 1 Silencing of circ-NT5C2 retards the progression of IL-1beta-induced osteoarthritis in an in vitro cell model by targeting the miR-142-5p/NAMPT axis. - hsa_circ_NT5C2 circ-NT5C2 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Collectively, circ-NT5C2 accelerated the OA process by targeting the miR-142-5p/NAMPT axis. This study provides valuable information to find a better treatment for OA." 1 Circ_0018909 knockdown inhibits the development of pancreatic cancer via the miR-545-3p/FASN axis and reduces macrophage polarization to M2. hsa_circ_0018909 hsa_circ_VDAC2 Circ_0018909 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated Circ_0018909 knockdown retarded the development of pancreatic cancer by modulating miR-545-3p to regulate FASN expression. 1 Role of m6A modification and novel circ_0066715/ miR-486-5p/ ETS1 axis in rheumatoid arthritis macrophage polarization progression. hsa_circ_0066715 hsa_circ_CBLB circ_0066715 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "The overexpression of circ_0066715 significantly increased the ETS1 levels in RA-FLS cells, decreased cytokine secretion by M1-type macrophages, elevated M2-type cytokines, and inhibited FLS proliferation." 1 Circ-IGF1R Affects the Progression of Colorectal Cancer by Activating the miR-362-5p/HMGB3-Mediated Wnt/beta-Catenin Signal Pathway. - hsa_circ_IGF1R Circ-IGF1R DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated This study hypothesized that circ-IGF1R sponged miR-362-5p to regulate HMGB3 level and activate HMGB3/Wnt/beta-catenin pathway in CRC cell development. 1 Circular RNA Circ_0005962 Contributes to Lung Adenocarcinoma Cell Proliferation and Stem Cell Formation Through Sponging of miR-3611 and Modulating CYP24A1 Expression. hsa_circ_0005962 hsa_circ_YWHAZ circ_0005962 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "Together, circ_0005962 was overexpressed in LUAD, and its deficiency repressed LUAD progression via targeting the miR-3611/ CYP24A1 axis, providing a novel mechanism for understanding the development of LUAD." 1 circ-ZEB1 regulates epithelial-mesenchymal transition and chemotherapy resistance of colorectal cancer through acting on miR-200c-5p. - hsa_circ_ZEB1 circ-ZEB1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "In conclusion, circ-ZEB1 could promote CRC cells progression, EMT, and chemoresistance via acting on miR-200c, elucidating a potential therapeutic target to inhibit CRC progression. " 1 CircBFAR correlates with poor prognosis and promotes laryngeal squamous cell cancer progression through miR-31-5p/COL5A1 axis. hsa_circ_00090655 hsa_circ_BFAR CircBFAR DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "CircBFAR, miR-31-5p, and COL5A1 in LSCC progression might provide novel therapeutic targets for LSCC clinical intervention." 1 Hsa_circ_0092887 targeting miR-490-5p/UBE2T promotes paclitaxel resistance in non-small cell lung cancer. hsa_circ_0092887 hsa_circ_DHTKD1 circ_0092887 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Hsa_circ_0092887 depletion alleviated PTX-resistance in NSCLC cells via modulating the miR-490-5p/UBE2T axis, and the targeted management of hsa_circ_0092887-mediated signaling axis might contribute to PTX-resistance intervention in NSCLC." 1 Circ_0083964 knockdown impedes rheumatoid arthritis progression via the miR-204-5p-dependent regulation of YY1. hsa_circ_0083964 hsa_circ_ASH2L Circ_0083964 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "Circ_0083964 inhibition confined RA development by sponging miR-204-5p to hamper the YY1 level, which will provide a theoretical basis for the treatment of RA." 3 CircDOCK1 Regulates miR-186/DNMT3A to Promote Osteosarcoma Progression. hsa_circ_0020378 hsa_circ_DOCK1 CircDOCK1 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "CircDOCK1 promotes OS progression by interacting with miR-186/DNMT3ADNMT3A, representing a novel therapeutic approach." 4 "circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in small cell lung cancer." hsa_circ_0001821 hsa_circ_PVT1 circPVT1 DOID:5409 lung small cell carcinoma small cell lung cancer RT-qPCR up-regulated "In conclusion, we have uncovered a functional role of circular and chimeric PVT1 transcripts in SCLC; these entities may prove useful as novel biomarkers in MYC-amplified tumors." 1 Circular RNA circ0104103 inhibits colorectal cancer progression through interactions with HuR and miR-373-5p. hsa_circ_0104103 hsa_circ_LACTB circ0104103 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Taken together, our study revealed that circ0104103 acts as a tumor suppressor and may be a novel biomarker and therapeutic target in CRC." 1 "CircDUSP1 regulates tumor growth, metastasis, and paclitaxel sensitivity in triple-negative breast cancer by targeting miR-761/DACT2 signaling axis." hsa_circ_0075043 hsa_circ_DUSP1 CircDUSP1 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "Taken together, our findings revealed a role for the regulation of the miR-761/DACT2 axis by circDUSP1 in the biological process of TNBC. These results provided new insights into the biological mechanism and targeted therapy of TNBC." 1 CircPDIA4 Induces Gastric Cancer Progression by Promoting ERK1/2 Activation and Enhancing Biogenesis of Oncogenic circRNAs. - hsa_circ_PDIA4 CircPDIA4 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated These findings reveal a dual tumor-promoting mechanism for circPDIA4 by regulating oncogenic circRNA biogenesis and increasing MAPK activity. CircPDIA4 should be investigated further as a potential prognostic biomarker and therapeutic target in gastric cancer. 1 Circular RNA expression profile identifies circMGEA5 as a novel metastasis-promoting factor and potential biomarker in osteosarcoma. - hsa_circ_MGEA5 circMGEA5 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "In sum, our findings, for the first time, reveal the metastasis-promoting role of circMGEA5 in OS. Targeting of this newly identified ceRNA axis may be crucial in the development of novel therapies for metastatic OS patients." 1 Circular RNA Sec61 subunit alpha isoform 1 by competitive absorption of microRNA-513a-5p mediates peroxisomal biogenesis factor 5 expression and promotes the malignant phenotype of non-small cell lung cancer. hsa_circ_0007841 hsa_circ_SEC61A1 circSEC61A1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Generally, circSEC61A1 is a potential biomarker for NSCLC, and circSEC61A1 serves tumor-promoting action in the progression of NSCLC." 2 Knockdown of hsa_circ_0008922 inhibits the progression of glioma. hsa_circ_0008922 hsa_circ_MATR3 circ_0008922 DOID:0060108 brain glioma glioma "RT-qPCR, RNA-seq" up-regulated "We found that the expression of hsa_circ_0008922 in glioma tissues was 3.4 times higher than that in normal tissues. The expression of has_circ_0008922 was correlated with WHO tumor grade. After down-regulating the expression of hsa_circ_0008922, malignant biological behavior of glioma cells was inhibited, such as cell proliferation, colony formation, migration, and invasion." 1 Hsa_circ_0020378 targets miR-556-5p/MAPK1 to regulate osteosarcoma cell proliferation and migration. hsa_circ_0020378 hsa_circ_DOCK1 circ_0020378 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Circ_0020378 acts as a novel tumor promoter that controls OS growth by miR-556-5p/MAPK1 axis, suggesting circ_0020378/miR-556-5p/MAPK1 might be a novel target for OS intervention." 4 Circular RNA hsa_circ_0008003 promotes the progression of non-small-cell lung cancer by sponging miR-548I and regulating KPNA4 expression. hsa_circ_0008003 hsa_circ_LDB2 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circular RNA hsa_circ_0008003 promoted progression in NSCLC by sponging miR-548I and regulating KPNA4 expression, hinting that circ_0008003 participates in NSCLC pathogenesis." 4 "circTAB2 inhibits lung cancer proliferation, migration and invasion by sponging miR-3142 to upregulate GLIS2." hsa_circ_0078200 hsa_circ_TAB2 circTAB2 DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "Taken together, circTAB2 serves as an inhibitory role in lung cancer through a novel circTAB2 /miR-3142 /GLIS2 /AKT pathway and could be exploited a novel marker in lung cancer." 1 Circ_0006220 Contributes to NSCLC Progression through miR-342-3p/GOT2 Axis. hsa_circ_0006220 hsa_circ_TADA2A Circ_0006220 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0006220 promoted the malignant behaviors of NSCLC cells through mediating the miR-342-3p/GOT2 regulation cascade. 6 Circ-PGAM1 Enhances Matrine Resistance of Non-Small Cell Lung Cancer via the miR-326/CXCR5 Axis. - hsa_circ_PGAM1 Circ-PGAM1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ-PGAM1 enhances matrine resistance of NSCLC cells through the miR-326/CXCR5 axis. The authors findings provide new insights into NSCLC-targeted therapy. 1 circRNA DENND1B inhibits tumorigenicity of clear cell renal cell carcinoma via miR-122-5p/TIMP2 axis. hsa_circ_0000168 hsa_circ_DENND1B - DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, RNA-seq" down-regulated "circ_DENND1B inhibited ccRCC cell progression by promoting TIMP2 expression by sponging miR-122-5p, suggesting that circ_DENND1B might be an effective therapeutic target for ccRCC." 1 Circ_0001060 Upregulates and Encourages Progression in Osteosarcoma. hsa_circ_0001060 hsa_circ_UXS1 Circ_0001060 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "To sum up, circ_0001060 is a novel tumor biomarker for OS as well as a potential therapeutic target." 1 Hsa_circ_0049396 inhibited oral squamous cell carcinoma progression by regulating the miR-663b/ENDOU axis. hsa_circ_0049396 hsa_circ_LDLR circ_0049396 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "Our study illustrated that circ_0049396 overexpression inhibited the malignant behavior of OSCC cells by regulating the miR-663b/ENDOU axis. Based on our findings, circ_0049396 can be used as a potential therapeutic agent for OSCC." 1 Circ_0006646 Accelerates the Growth and Metastasis of Cervical Cancer by Elevating RRM2 Through miR-758-3p. hsa_circ_0006646 hsa_circ_PTK2 Circ_0006646 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Circ_0006646 expedited CC cell growth and metastasis by regulating miR-758-3p/RRM2 axis, and exosomal circ_0006646 might be a potential diagnostic indicator of CC." 2 Circ_0026218 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell dysfunction by regulating miR-188-3p/TLR4/NF-kappaB pathway. hsa_circ_0026218 hsa_circ_CERS5 Circ_0026218 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Circ_0026218 knockdown attenuated ox-LDL-induced dysfunction in HUVECs via regulating miR-188-3p/TLR4/NF-kB pathway. 2 Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs. hsa_circ_0047886 hsa_circ_ZCCHC2 - DOID:332 amyotrophic lateral sclerosis amyotrophic lateral sclerosis "RT-qPCR, RNA-seq" down-regulated "A summary of the changes for circRNAs based on RT-qPCR analysis in human and mouse tissues is shown in Table 4. Several circRNAs showed consistent changes in human and mouse skeletal muscle (5 upregulated and 4 downregulated circRNAs). Several circRNAs also showed consistent changes (all decreased) in human and mouse spinal cord tissues, including hsa_circ_0000119, hsa_circ_0000567, hsa_circ_0005171, hsa_circ_0047886, hsa_circ_0001948, and hsa_circ_0000033." 1 Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs. hsa_circ_0001948 hsa_circ_CD99L2 - DOID:332 amyotrophic lateral sclerosis amyotrophic lateral sclerosis "RT-qPCR, RNA-seq" down-regulated "A summary of the changes for circRNAs based on RT-qPCR analysis in human and mouse tissues is shown in Table 4. Several circRNAs showed consistent changes in human and mouse skeletal muscle (5 upregulated and 4 downregulated circRNAs). Several circRNAs also showed consistent changes (all decreased) in human and mouse spinal cord tissues, including hsa_circ_0000119, hsa_circ_0000567, hsa_circ_0005171, hsa_circ_0047886, hsa_circ_0001948, and hsa_circ_0000033." 1 Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs. hsa_circ_0000033 hsa_circ_CEP85 - DOID:332 amyotrophic lateral sclerosis amyotrophic lateral sclerosis "RT-qPCR, RNA-seq" down-regulated "A summary of the changes for circRNAs based on RT-qPCR analysis in human and mouse tissues is shown in Table 4. Several circRNAs showed consistent changes in human and mouse skeletal muscle (5 upregulated and 4 downregulated circRNAs). Several circRNAs also showed consistent changes (all decreased) in human and mouse spinal cord tissues, including hsa_circ_0000119, hsa_circ_0000567, hsa_circ_0005171, hsa_circ_0047886, hsa_circ_0001948, and hsa_circ_0000033." 1 An evaluation of gastric adenocarcinoma-associated CircRNAs based on microarray meta-analysis and ceRNA networks. hsa_circ_0002019 hsa_circ_FOXRED1 - DOID:3717 gastric adenocarcinoma gastric adenocarcinoma "RT-qPCR, microarray" up-regulated "A microarray meta-analysis of circRNAs revealed 32 dysregulated circRNAs in GAC. Using real-time PCR, the expression levels of one up-regulated circRNA (hsa_circ_0002019) and one down-regulated circRNA (hsa_circ_0074736) were evaluated in plasma samples." 1 An evaluation of gastric adenocarcinoma-associated CircRNAs based on microarray meta-analysis and ceRNA networks. hsa_circ_0074736 hsa_circ_GEMIN5 - DOID:3717 gastric adenocarcinoma gastric adenocarcinoma "RT-qPCR, microarray" down-regulated "A microarray meta-analysis of circRNAs revealed 32 dysregulated circRNAs in GAC. Using real-time PCR, the expression levels of one up-regulated circRNA(hsa_circ_0002019)_nd one down-regulated circRNA (hsa_circ_0074736)_ere evaluated in plasma samples." 1 Inhibition by rno-circRNA-013017 of the apoptosis of motor neurons in anterior horn and descending axonal degeneration in rats after traumatic spinal cord injury. - - rno-circRNA-013017 DOID:319 spinal cord disease traumatic spinal cord injury RT-qPCR down-regulated "our future work will include rescue experiments on rno-circRNA-013017 and its target genes to verify their relationship in vitro and in vivo. Namely, we will verify the rno_circRNA_013017/rno-miR-16-5p/bcl-2 pathway in cell lines and then perform the animal experiments." 1 circPOLR1C Promotes the Development of Esophageal Cancer by Adsorbing miR-361-3p and Regulating Cancer Cell Apoptosis and Metastasis. hsa_circ_0076535 hsa_circ_POLR1C circPOLR1C DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated circPOLR1C adsorbs miR-361-3p and regulates apoptosis- and EMT-related gene expressions to promote the development of EC. 1 CircVAPA contributes to hyper-proliferation and inflammation of keratinocytes through miR-125b-5p/sirt6 axis in psoriasis. - hsa_circ_VAPA circVAPA DOID:8893 psoriasis psoriasis RT-qPCR up-regulated "CircVAPA participate in the progression of psoriasis through miR-125b-5p/sirt6 axis by regulating proliferation and inflammation of keratinocytes, highlighting a potential therapeutic target for psoriasis." 1 Hsa_circ_0000520 Promotes Non-Small Cell Lung Cancer Progression through the miR-1258/AKT3 Axis. hsa_circ_0000520 hsa_circ_RPPH1 circ_0000520 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ_0000520 upregulates AKT3 by competitively binding with miR-1258 to facilitate NSCLC progression. 2 Hsa_circ_0006988 Promotes Sorafenib Resistance of Hepatocellular Carcinoma by Modulating IGF1 Using miR-15a-5p. hsa_circ_0006988 hsa_circ_LDLRAD3 circ_0006988 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Hsa_circ_0006988 partly promoted the SOR-R of HCC cells through miR-15a-5p sequestering and upregulation of IGF1 levels. 1 Matrine inhibits hepatocellular carcinoma cell malignancy through the circ_0013290/miR-139-5p/MMP16 pathway. hsa_circ_0013290 hsa_circ_AGL circ_0013290 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Matrine inhibited HCC cell malignancy through the circ_0013290/miR-139-5p/MMP16 pathway, suggesting that Matrine is a potential therapeutic agent for HCC." 1 Exosome-derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase-3-dependent cleavage. hsa_circ_0008304 hsa_circ_TFDP2 circTFDP2 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "In general, our study demonstrated that circTFDP2 promoted PCa cell progression through the PARP1/DNA damage axis, which may be a promising therapeutic target for PCa." 1 Circ_0114428 Influences the Progression of Septic Acute Kidney Injury Via Regulating Mir-370-3p/Timp2 Axis. hsa_circ_0114428 hsa_circ_ZNF644 circ_0114428 DOID:557 kidney disease septic acute kidney injury RT-qPCR up-regulated "Our data demonstrated that circ_0114428 contributed to septic AKI progression by regulating miR-370-3p-mediated TIMP2 expression, which provided a promising target for septic AKI treatment." 1 Hsa_circ_0001944 enhanced GSPT1 expression via sponging miR-498 to promote proliferation and invasion of gastric cancer. hsa_circ_0001944 hsa_circ_FIRRE CircFIRRE DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated The present study demonstrates the hsa_circ_0001944/miR-498/GSPT1 axis contributes to GC development. This may provide a target for GC therapy and potential prognostic biomarker. 1 Silencing circUSP48 suppresses osteosarcoma progression by regulating the miR-335/ smad nuclear interacting protein 1 pathway. hsa_circ_0000028 hsa_circ_USP48 circUSP48 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Overall, these findings suggested that circUSP48 acted as an oncogene in OS, which might become a new target for OS therapy." 1 "Hsa_circ_0097009 regulates proliferation, apoptosis, migration and invasion of hepatocellular carcinoma cells via miR-568/RNF38 axis." hsa_circ_0097009 hsa_circ_SLC5A8 circ_0097009 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Together, this study indicated that the oncogenic function of circ_0097009 in HCC, and circ_0097009/miR-568/RNF38 axis was expected to be a novel therapeutic option for HCC patients." 1 Suppression of exosomal hsa_circ_0001005 eliminates the Vemurafenib resistance of melanoma. hsa_circ_0001005 hsa_circ_ASB3 circ_0001005 DOID:1909 melanoma melanoma "RT-qPCR, RNA-seq" up-regulated "This study confirmed that the level of hsa_circ_0001005 in exosomes is the key factor affecting drug resistance of melanoma, which provides a new potential therapeutic target for melanoma patients." 1 Identification of Circular RNA Circ_0003256 as a Novel Player in Pediatric Acute Myeloid Leukemia. hsa_circ_0003256 hsa_circ_CIT circ_0003256 DOID:70323 childhood acute myeloid leukemia pediatric acute myeloid leukemia RT-qPCR up-regulated Our findings identify that suppression of circ_0003256 impedes the malignant behaviors of pediatric AML cells by regulating PRKACB expression by competing for shared miR-582-3p. 1 "METTL3-mediated Hsa_circ_0000390 downregulation enhances the proliferation, migration, and invasion of colorectal cancer cells by increasing Notch1 expression." hsa_circ_0000390 hsa_circ_FGD4 circ_0000390 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated This study suggested that circ_0000390 might be anti-tumor factor in CRC and METTL3/Notch1 might be a therapeutic targets for CRC. 1 Circ_0002762 Regulates Oncoprotein YBX1 in Cervical Cancer via mir-375 to Regulate the Malignancy of Cancer Cells. hsa_circ_0002762 hsa_circ_CDK17 circ_0002762 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Circ_0002762 promotes the progression of CC via sponging miR-375 and up-regulating YXB1 expression. 4 CircRNA B cell linker regulates cisplatin sensitivity in nonsmall cell lung cancer via microRNA-25-3p/BarH_like homeobox 2 axis. - hsa_circ_BLNK - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated Circ_BLNK promoted the DDP sensitivity of NSCLC via regulating miR-25-3p/BARX2 axis. 1 Circ_0124055 promotes the progression of thyroid cancer cells through the miR-486-3p/MTA1 axis. hsa_circ_0124055 hsa_circ_DAG1 "circ_0124055, circDAG1" DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated Circ_0124055 promoted the progression of thyroid cancer cells through the miR-486-3p /MTA1 axis. 1 CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post-translational modification. hsa_circ_0006381 hsa_circ_ZSWIM6 circZSWIM6 DOID:0080001 bone disease ageing chondrocytes "RT-qPCR, RNA-seq" up-regulated Our results revealed a significant role of CircZSWIM6 in age-related OA by regulating ECM metabolism and AMPK-associated energy metabolism. We highlight the CircZSWIM6-RPS14-PCK1-AMPK axis is a potential biomarker for OA. 1 Hypoxia-induced miR-653 enhances colorectal cancer progression by targeting circSETD3/KLF6 axis. - hsa_circ_SETD3 circSETD3 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Taken together, these findings indicated that circSETD3/miR-653/KLF6 axis may be an effective therapeutic target for CRC patients." 2 CircAGK regulates high dihydrotestosterone-induced apoptosis in DPCs through the miR-3180-5p/BAX axis. hsa_circ_0002980 hsa_circ_AGK circAGK DOID:0050801 androgenic alopecia androgenetic alopecia "RT-qPCR, RNA-seq" up-regulated "By regulating the miR-3180-5p/BAX axis, circAGK promotes DPC apoptosis in a high DHT environment in vitro and inhibits hair growth in AGA mice in vivo, indicating that circAGK is a potential target for the clinical treatment of AGA." 1 Circular RNA Fibroblast Growth Factor Receptor 1 Promotes Pancreatic Cancer Progression by Targeting MicroRNA-532-3p/PIK3CB Axis. - hsa_circ_FGFR1 - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "Our data revealed that circFGFR1 driven the malignant progression of PDAC by targeting miR-532-3p/PIK3CB axis, suggesting that inhibition of circFGFR1 might be considered as a therapeutic target for PDAC." 1 Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population. hsa_circ_0000264 hsa_circ_CHST15 circCHST15 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated The results of this study suggested that genetic variants of circCHST15 may contribute to OSCC susceptibility. 1 Circ_0001721 knockdown relieves IL-1beta-induced chondrocyte injury via regulating miR-373-3p/CXCR4 in osteoarthritis. hsa_circ_0001721 - circ_0001721 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Our data confirmed that circ_0001721 knockdown alleviated IL-1beta-induced chondrocyte injury by miR-373-3p/CXCR4 axis, which suggested that circ_0001721 might be a potential therapeutic target for OA." 1 Circ_0101692 knockdown retards the development of clear cell renal cell carcinoma through miR-384/FN1 pathway. hsa_circ_0101692 hsa_circ_EGLN3 circ_0101692 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated This points out that circ_0101692/miR-384/FN1 axis might be a prospective target implemented for the future treatment of ccRCC. 2 Depletion of circ_0006459 protects human brain microvascular endothelial cells from oxygen-glucose deprivation-induced damage through the miR-940/FOXJ2 pathway. hsa_circ_0006459 hsa_circ_GNAQ circ_0006459 DOID:6713 cerebrovascular disease ischemic stroke RT-qPCR up-regulated "Depletion of circ_0006459 protected human brain microvascular endothelial cells from oxygen-glucose deprivation-induced damage through miR-940/FOXJ2 pathway, providing a promising therapeutic target for ischemic stroke." 1 Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFkappaB pathway. hsa_circ_0021727 hsa_circ_CD44 circ_0021727 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "In short, hsa_circ_0021727 promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NF¦ĘB pathway. These findings might provide potential targets to treat ESCC." 1 CircNRIP1 KNOCKDOWN ALLEVIATES LIPOPOLYSACCHARIDE-INDUCED HUMAN KIDNEY 2 CELL APOPTOSIS AND INFLAMMATION THROUGH miR-339-5p/OXSR1 PATHWAY. - hsa_circ_NRIP1 circNRIP1 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated CircNRIP1 depletion ameliorated LPS-induced HK2 cell damage by regulating the miR-339-5p/OXSR1 pathway. 1 Circular RNA_0003800 exacerbates IL-1beta-induced chondrocyte injury via miR-197-3p/SOX5 axis. hsa_circ_0003800 hsa_circ_None circ_0003800 DOID:0080001 bone disease chondrocyte injury RT-qPCR up-regulated circ_0003800 exacerbates IL-1beta-induced chondrocyte injury via miR-197-3p/SOX5 axis. 1 Circular RNA circEMB promotes osteosarcoma progression and metastasis by sponging miR-3184-5p and regulating EGFR expression. hsa_circ_0001481 hsa_circ_EMB circEMB DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq" up-regulated "CircEMB plays a critical role in promoting cancer via the miR-3184-5p/EGFR pathway, indicating that circEMB may serve as a therapeutic target for OSA." 1 Hsa_circ_0015278 Regulates FLT3-ITD AML Progression via Ferroptosis-Related Genes. hsa_circ_0015278 hsa_circ_KLHL20 circ_0015278 DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, microarray" up-regulated "In summary, we constructed the hsa_circ_0015278/miRNAs/FerRGs signaling axis, which provides new insight into the pathogenesis and therapeutic targets of AML with FLT3-ITD mutation." 1 Tumor Cell-Derived Exosomal circ-PRKCI Promotes Proliferation of Renal Cell Carcinoma via Regulating miR-545-3p/CCND1 Axis. hsa_circ_0067934 hsa_circ_PRKCI circ-PRKCI DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "In conclusion, this study will provide a new understanding about the molecular mechanisms of RCC progression." 1 circRNA circSnx12 confers Cisplatin chemoresistance to ovarian cancer by inhibiting ferroptosis through a miR-194-5p/SLC7A11 axis. - hsa_circ_SNX12 circSnx12 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated CircARNT2 may thus serve as an effective therapeutic target for overcoming cisplatin resistance in OC. 1 Has_circ_0048764 promotes breast cancer progression by sponging miR-578 and regulating HMGA2 expression. hsa_circ_0048764 hsa_circ_RPL36 circ_0048764 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_0048764 promotes BC cell growth, migration and invasion via absorbing miR-578 and up-regulating HMGA2." 2 CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway. hsa_circ_0004721 hsa_circ_HGS CircHGS DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated Our findings indicated that circHGS promotes BCa progression via the miR-513a-5p/VEGFC/AKT/mTOR pathway and can be a promising therapeutic target of BCa. 1 Detecting plasma hsa_circ_0061276 in patients with gastric cancer by reverse transcription-digital polymerase chain reaction. hsa_circ_0061276 hsa_circ_NRIP1 circ_0061276 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Hsa_circ_0061276 may be a new biomarker for gastric cancer. The tumor suppressor role of hsa_circ_0061276 on gastric cancer likely occurs through a sponge effect on miRNAs such as hsa-miR-7705. 6 Circular RNA SESN2 aggravates gestational trophoblast cell damage induced by high glucose by binding to IGF2BP2. - hsa_circ_SESN2 circSESN2 DOID:11714 gestational diabetes Gestational diabetes mellitus RT-qPCR up-regulated "Collectively, circSESN2 exacerbated HG-induced trophoblast cell damage by binding IGF2BP2 and upregulating its protein expression." 1 Circular RNA circPOFUT1 enhances malignant phenotypes and autophagy-associated chemoresistance via sequestrating miR-488-3p to activate the PLAG1-ATG12 axis in gastric cancer. hsa_circ_0059773 hsa_circ_POFUT1 circPOFUT1 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Our findings show the potential of circPOFUT1 as biomarkers and targeting circPOFUT1 as a therapeutic strategy for GC. 1 circFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p. - hsa_circ_FLNA circFLNA DOID:5295 intestinal disease intestinal injury RT-qPCR up-regulated The circFLNA/miR-766-3p/Fas axis has potential as a novel therapeutic target for treating intestinal injury in sepsis. 1 CircMAN1A2 contributes to nasopharyngeal carcinoma progression via enhancing the ubiquitination of ATMIN through miR-135a-3p/UBR5 axis. - hsa_circ_MAN1A2 CircMAN1A2 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "Together, our study uncovered the tumor-initiating and pro-metastatic role of circMAN1A2-miR-135a-3p-UBR5-ATMIN axis in NPC regulation that may be a potential therapeutic target for human NPC." 2 Increased transcription of hsa_circ_0000644 upon RUNX family transcription factor 3 downregulation participates in the malignant development of bladder cancer. hsa_circ_0000644 hsa_circ_KIAA1199 circ_0000644 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated This study demonstrates that transcriptional activation of circ_644 upon RUNX3 downregulation drives the malignant development of BCa through the miR-143-3p/MSI2 axis. RUNX3 restoration or specific inhibition of circ_644 or MSI2 may help block BCa progression. 1 Circular RNA hsa_circ_0000519 contributes to angiogenesis and tumor progression in hepatocellular carcinoma through the miR-1296/E2F7 axis. hsa_circ_0000519 hsa_circ_RPPH1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated These data suggest the potential clinical application of hsa_circ_0000519 in HCC treatment. 6 Circular RNA FOXO3 regulates endometrial carcinoma progression through the microRNA-29a-3p/HDAC4 axis. hsa_circ_0006404 hsa_circ_FOXO3 - DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "In conclusion, circ_FOXO3 promotes EC progression by sponging miR-29a-3p and upregulating HDAC4, making it a promising therapeutic target in EC." 1 Hsa_circ_0008673 Promotes Breast Cancer Progression by MiR-578/GINS4 Axis. hsa_circ_0008673 hsa_circ_BRCA1 circ_0008673 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Hsa_circ_0008673 might promote BC progression via modulating miR-578/GINS4 pathway. 2 Circ-0000979 promotes the development of gastric carcinoma by sponging miR-136 and modulating SP1 mRNA expression level. hsa_circ_0000979 hsa_circ_TCONS_00003590 Circ-0000979 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Taken together, our results demonstrated that circ-0000979, as a carcinogenic circRNA, promotes the progression of GC by regulating the miR-136/SP1 pathway. Circ-0000979 is a potential RNA-based therapeutic target for GC treatment." 1 Apelin promotes osteosarcoma metastasis by upregulating PLOD2 expression via the Hippo signaling pathway and hsa_circ_0000004/miR-1303 axis. hsa_circ_0000004 hsa_circ_ATAD3B circ_0000004 DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, RNA-seq, microarray" up-regulated "APLN increased PLOD2 expression in human osteosarcoma cell lines and cell migration via the mammalian Sterile 20-like kinase 1 (MST1), monopolar spindle-one-binder protein (MOB)1, and YAP cascades, and through hsa_circ_0000004 functioning as a sponge of miR-1303." 1 Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1. hsa_circ_0031584 hsa_circ_ARHGAP5 - DOID:3744 cervical squamous cell carcinoma cervical squamous cell carcinoma RT-qPCR down-regulated "Collectively, our data indicated that circARHGAP5 directly bound to AUF1 and prevented AUF1 from interacting with BIM mRNA, thereby playing a pivotal role in cisplatin resistance in CSCC. Our study provides insights into overcoming cancer resistance to cisplatin treatment." 1 Circ_0060937 Contributes to the Development of Lung Cancer via Positively Regulating LAD1 Expression by Binding to miR-1304-5p. hsa_circ_0060937 hsa_circ_CYP24A1 circ_0060937 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated Circ_0060937 downregulation decreased the expression of LAD1 by releasing miR-1304-5p to effectively repress lung cancer cell growth and in vivo tumorigenesis. 1 "Circ_0001821 Potentiates Cell Growth, Metastasis, and Stemness in Colorectal Cancer by Regulating miR-339-3p/CST1." hsa_circ_0001821 hsa_circ_CSPP1 circ_0001821 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0001821 promoted CRC cell proliferation, migration, invasion, and stemness by regulating the miR-339-3p/CST1 axis." 3 Circ_0001402 knockdown suppresses the chemoresistance and development of DDP-resistant cutaneous squamous cell carcinoma cells by functioning as a ceRNA for miR-625-5p. hsa_circ_0001402 hsa_circ_TBC1D1 circ_0001402 DOID:1749 squamous cell carcinoma squamous cell carcinoma "RT-qPCR, microarray" up-regulated Circ_0001402 knockdown can suppress the development and chemoresistance of DDP-resistant CSCC cells at least partly through targeting miR-625-5p/KPNA4 axis. 1 Circular RNA circTRPS1-2 inhibits the proliferation and migration of esophageal squamous cell carcinoma by reducing the production of ribosomes. - hsa_circ_TRPS1-2 circTRPS1-2 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" down-regulated "Our results suggest that circTRPS1-2 can inhibit ESCC proliferation and migration by reducing the production of ribosomes, establishing its potential usefulness in ESCC treatment and prediction of prognosis." 1 The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-beta pathway. hsa_circ_0069280 hsa_circ_NCAPG circNCAPG DOID:0060108 brain glioma glioma RT-qPCR up-regulated Our findings support the existence of a novel feedback loop U2AF65/circNCAPG/RREB1 that promotes malignant progression in GSCs and could be a novel therapeutic target for glioma patients. 1 CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export. hsa_circ_0007334 hsa_circ_MBOAT2 circMBOAT2 DOID:4928 intrahepatic cholangiocarcinoma intrahepatic cholangiocarcinoma RT-qPCR up-regulated "Our results identified that circMBOAT2 was upregulated in ICC and promoted progression by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export, which altered lipid metabolic profile and regulated redox homeostasis in ICC, suggesting that circMBOAT2 may serve as an available therapeutic target for ICC with active lipid metabolism." 1 CircZNF236 facilitates malignant progression in oral squamous cell carcinoma by sequestering miR-145-5p. - hsa_circ_ZNF236 circZNF236 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated CircZNF236 modulates OSCC via the miR-145-5p/MBTD1 axis. These results support the potential of circZNF236 as a treatment target for OSCC. 1 CircNDC80 promotes glioblastoma multiforme tumorigenesis via the miR-139-5p/ECE1 pathway. hsa_circ_0046706 hsa_circ_NDC80 circNDC80 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "According to our research, circNDC80 is an oncogenic factor that promotes glioblastoma through the miR-139-5p/ECE1 pathway. This implies that circNDC80 may be employed as a novel therapeutic target and a possible predictive biomarker." 1 Guggulsterone Promotes Nasopharyngeal Carcinoma Cells Exosomal Circfip1L1 to Mediate miR-125a-5p/VEGFA Affecting Tumor Angiogenesis. hsa_circ_0069740 hsa_circ_FIP1L1 circFIP1L1 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated GS promoted exosomal circFIP1L1 in NPC cells to mediate miR-125a-5p/VEGFA axis affecting tumor angiogenesis. 2 The hsa_circ_0007396-miR-767-3p-CHD4 axis is involved in the progression and carcinogenesis of gastric cancer. hsa_circ_0007396 hsa_circ_MYO9B circ_0007396 DOID:10534 stomach cancer gastric cancer microarray up-regulated "We identified an important hsa_circ_0007396-miR-767-3p-CHD4 axis, which is associated with GC proliferation and carcinogenesis, and may represent a promising therapeutic target for the future cure of GC." 1 Circ-N4BP2L2 enhances mitochondrial function in non-small cell lung cancer cells through regulating the miR-135a-5p/ARL5B axis. - hsa_circ_N4BP2L2 circ-N4BP2L2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Taken together, circ-N4BP2L2 enhanced NSCLC progression via the miR-135a-5p/ARL5B axis, which may provide a novel therapeutic target of NSCLC." 1 CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain. - rno_circ_Fhit circFhit DOID:936 brain disease neuropathic pain RT-qPCR up-regulated "In summary, we revealed that the exon-intron circFhit contributes to GABAergic neuron-mediated NK1R+ neuronal hyperexcitation and neuropathic pain via regulating Fhit in cis." 1 CircIFNGR2 enhances proliferation and migration of CRC and induces cetuximab resistance by indirectly targeting KRAS via sponging to MiR-30b. hsa_circ_0001185 hsa_circ_IFNGR2 circIFNGR2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "We predicted that circIFNGR2 could sponged miR-30b via bioinformatic method and subsequently confirmed that circIFNGR2 promoted the proliferation and migration of CRC cells by targeting miR-30b/KRAS. In addition, we demonstrated that circIFNGR2 might act as a potential chemotherapy resistance marker in CRC." 1 CircStrn3 targeting microRNA-9-5p is involved in the regulation of cartilage degeneration and subchondral bone remodelling in osteoarthritis. - mmu_circ_Strn3 circStrn3 DOID:8398 osteoarthritis osteoarthritis "RT-qPCR, RNA-seq" down-regulated "Taken together, these results demonstrate that reduction of circStrn3 causes an increase in miR-9-5p, which acts as a protective factor in mechanical instability-induced OA, and provides a novel mechanism of communication among joint components and a potential application for the treatment of OA." 1 Circ_0004491 stimulates guanine nucleotide-binding protein alpha subunit to inhibit the malignant progression of oral squamous cell carcinoma by sponging miR-2278. hsa_circ_0004491 hsa_circ_ORC4 circ_0004491 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "Circ_0004491 can repress OSCC progression by regulation of miR-2278/GNAS axis, providing a possible circRNA-targeted therapy for OSCC." 2 Circ_0138960 knockdown alleviates lipopolysaccharide-induced inflammatory response and injury in human dental pulp cells by targeting miR-545-5p/MYD88 axis in pulpitis. hsa_circ_0138960 hsa_circ_GDA circ_0138960 DOID:11121 pulpitis pulpitis RT-qPCR up-regulated Circ_0138960 knockdown attenuated LPS-induced inflammatory response and injury in hDPCs by targeting the miR-545-5p/MYD88/NF-kB axis. 1 Anti-apoptosis and anti-inflammation activity of circ_0097010 downregulation in lipopolysaccharide-stimulated periodontal ligament cells by miR-769-5p/Kruppel like factor 6 axis. hsa_circ_0097010 - circ_0097010 DOID:824 periodontitis Periodontitis RT-qPCR up-regulated These data identify circ_0097010 as a key regulator of LPS-induced inflammation and apoptosis in hPDLCs and highlight a novel mechanism of circ_0097010 regulation through miR-769-5p/KLF6 axis. 1 Hsa_circ_0005050 regulated the progression of oral squamous cell carcinoma via miR-487a-3p/CHSY1 axis. hsa_circ_0005050 hsa_circ_XPO1 circ_0005050 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated Circ_0005050 acted as an oncogenic factor in OSCC progression through miR-487a-3p/CHSY1 axis. 2 Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis. hsa_circ_0001811 hsa_circ_STAU2 circSTAU2 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" down-regulated "Exosome-delivered circSTAU2 may act as a tumor suppressor that restrains GC progression via miR-589/CAPZA1 axis, which demonstrates a potential therapeutic target for GC." 1 Serum circular RNA hsa_circ_0000702 as a novel biomarker for diagnosis of gastric cancer. hsa_circ_0000702 hsa_circ_CHD9 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Serum hsa_circ_0000702 was variably expressed in GC patients, indicating that serum hsa_circ_0000702 may be a novel biomarker for GC diagnosis and dynamic monitoring." 1 "Circular RNA SPI1 expression before and after induction therapy and its correlation with clinical features, treatment response, and survival of acute myeloid leukemia patients." hsa_circ_0000303 hsa_circ_SPI1 circ-SPI1 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "Decreased circ-SPI1 expression is related to lower WBC, favorable risk stratification, and better therapy response; moreover, its decline during therapy is an independent factor to predict longer EFS and OS in AML patients." 2 Evaluation of Circ_0000977-Mediated Regulatory Network in Breast Cancer: A Potential Discriminative Biomarker for Triple-Negative Tumors hsa_circ_0000977 hsa_circ_NOL10 circ_0000977 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated This study uncovered the potential clinical implication of circ_0000977 for the diagnosis and treatment of TNBC patients. 4 Hsa_circ_0000078 Regulates miR-205-5p/EREG Pathway to Inhibit Cervical Cancer Progression. hsa_circ_0000078 hsa_circ_USP1 circ_0000078 DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated "Circ_0000078 inhibits the growth of cancer by interfering with the miR-205-5p/EREG network, acting as a tumor suppressor in CC. These results provide a better understanding of the pathogenesis of this disease." 1 Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223-3p/NLRP3 axis. - hsa_circ_PWWP2A circPWWP2A DOID:850 lung disease lung inflammation and fibrosis RT-qPCR up-regulated Our study found that circPWWP2A could adsorb miR-223_3p to regulate NLRP3 after silica stimulation in pulmonary fibrosis. 1 CircLPAR1 Promotes Neuroinflammation and Oxidative Stress in APP/PS1 Mice by Inhibiting SIRT1/Nrf-2/HO-1 Axis Through Destabilizing GDF-15 mRNA. - mmu_circ_LPAR1 circLPAR1 DOID:231 motor neuron disease neuroinflammation RT-qPCR up-regulated "Herein, UPF1 was predicted to have binding sites on both circLPAR1 and GDF-15 using starBase (version 3.0); therefore, we speculated that circLPAR1 might regulate the expression of GDF-15 through the interaction with UPF1, thus participating in AD pathogenesis." 1 Circular RNA hsa_circ_0075323 promotes glioblastoma cells proliferation and invasion via regulation of autophagy. hsa_circ_0075323 hsa_circ_QSTM1 - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated Hsa_circ_0075323 regulates p62-mediated autophagy pathway to promote GBM progression and may serve as a prognostic biomarker potentially. 1 "Circ_0001326 suppresses trophoblast cell proliferation, invasion, migration and epithelial-mesenchymal transition progression in preeclampsia by miR-188-3p/HtrA serine peptidase 1 axis." hsa_circ_0001326 hsa_circ_PHLDB2 circ_0001326 DOID:10591 pre-eclampsia preeclampsia RT-qPCR up-regulated "Our study demonstrated that circ_0001326 could promote trophoblast cell proliferation, invasion, migration and EMT in PE by miR-188-3p/HTRA1 axis, indicating a novel insight into the pathogenesis of PE." 2 RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury. hsa_circ_0008898 hsa_circ_OAT - DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" up-regulated "Top five upregulated and five downregulated circRNAs with higher fold changes were selected for qPCR validation. Hsa_circ_0008898 (Fold Change = 5.48, p = 0.0376) and hsa_circ_0005519 (Fold Change = 4.65, p = 0.0071) were significantly upregulated, while hsa_circ_0132279 (Fold Change = -4.47, p = 0.0008), hsa_circ_0112327 (Fold Change = -4.26, p = 0.0048), and hsa_circ_0017647 (Fold Change = -4.15, p = 0.0313) were significantly downregulated in asphyxia-induced AKI group compared with the control group. " 1 RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury. hsa_circ_0005519 hsa_circ_SNX13 - DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" up-regulated "Top five upregulated and five downregulated circRNAs with higher fold changes were selected for qPCR validation. Hsa_circ_0008898 (Fold Change = 5.48, p = 0.0376) and hsa_circ_0005519 (Fold Change = 4.65, p = 0.0071) were significantly upregulated, while hsa_circ_0132279 (Fold Change = -4.47, p = 0.0008), hsa_circ_0112327 (Fold Change = -4.26, p = 0.0048), and hsa_circ_0017647 (Fold Change = -4.15, p = 0.0313) were significantly downregulated in asphyxia-induced AKI group compared with the control group. " 1 RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury. hsa_circ_0132279 hsa_circ_SLC17A5 - DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" down-regulated "Top five upregulated and five downregulated circRNAs with higher fold changes were selected for qPCR validation. Hsa_circ_0008898 (Fold Change = 5.48, p = 0.0376) and hsa_circ_0005519 (Fold Change = 4.65, p = 0.0071) were significantly upregulated, while hsa_circ_0132279 (Fold Change = -4.47, p = 0.0008), hsa_circ_0112327 (Fold Change = -4.26, p = 0.0048), and hsa_circ_0017647 (Fold Change = -4.15, p = 0.0313) were significantly downregulated in asphyxia-induced AKI group compared with the control group. " 1 RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury. hsa_circ_0112327 hsa_circ_NUP133 - DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" down-regulated "Top five upregulated and five downregulated circRNAs with higher fold changes were selected for qPCR validation. Hsa_circ_0008898 (Fold Change = 5.48, p = 0.0376) and hsa_circ_0005519 (Fold Change = 4.65, p = 0.0071) were significantly upregulated, while hsa_circ_0132279 (Fold Change = -4.47, p = 0.0008), hsa_circ_0112327 (Fold Change = -4.26, p = 0.0048), and hsa_circ_0017647 (Fold Change = -4.15, p = 0.0313) were significantly downregulated in asphyxia-induced AKI group compared with the control group. " 1 RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury. hsa_circ_0017647 hsa_circ_SFMBT2 - DOID:3021 acute kidney failure acute kidney injury "RT-qPCR, RNA-seq" down-regulated "Top five upregulated and five downregulated circRNAs with higher fold changes were selected for qPCR validation. Hsa_circ_0008898 (Fold Change = 5.48, p = 0.0376) and hsa_circ_0005519 (Fold Change = 4.65, p = 0.0071) were significantly upregulated, while hsa_circ_0132279 (Fold Change = -4.47, p = 0.0008), hsa_circ_0112327 (Fold Change = -4.26, p = 0.0048), and hsa_circ_0017647 (Fold Change = -4.15, p = 0.0313) were significantly downregulated in asphyxia-induced AKI group compared with the control group. " 1 CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability. hsa_circ_0065898 hsa_circ_VPRBP circVPRBP DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated "Taken together, the results demonstrate that circVPRBP is a potential prognostic biomarker and a novel therapeutic target for LN metastasis in CCa patients." 4 CircSMAD2 accelerates endometrial cancer cell proliferation and metastasis by regulating the miR-1277-5p/MFGE8 axis. hsa_circ_0000847 hsa_circ_SMAD2 circSMAD2 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated CircSMAD2 functions as an oncogene in promoting the progression of EC through miR-1277-5p/MFGE8 axis. 1 Silencing of circCRIM1 Drives IGF2BP1-Mediated NSCLC Immune Evasion. hsa_circ_0002346 hsa_circ_CRIM1 circCRIM1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated This study identifies circCRIM1 as a new tumor suppressor that inhibits tumor immune evasion through a competitive combination with IGF2BP1 to destabilize HLA-F mRNA. 2 CircZBTB46 Protects Acute Myeloid Leukemia Cells from Ferroptotic Cell Death by Upregulating SCD. hsa_circ_0002805 hsa_circ_ZBTB46 circZBTB46 DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, microarray" up-regulated "circZBTB46 protects AML cells from ferroptosis and promotes the proliferation by upregulating SCD, thus suggesting that circZBTB46 may be a potential therapeutic target for AML." 1 CircRNA-PI4KB Induces Hepatic Lipid Deposition in Non-Alcoholic Fatty Liver Disease by Transporting miRNA-122 to Extra-Hepatocytes. hsa_circ_0006892 hsa_circ_PI4KB circRNA-PI4KB DOID:80208 non-alcoholic fatty liver disease non-alcoholic fatty liver disease RT-qPCR up-regulated "The levels of circPI4KB in intra- and extra-hepatocytes corresponded to that of miRNA-122, and the overexpression of circPI4KB increased the miRNA-122 in extra-hepatocytes, consequently accomplishing a decreased protective role of miRNA-122 in inhibiting the lipid deposition." 1 Circ_0043256 upregulates KLF2 expression by absorbing miR-1206 to suppress the tumorigenesis of lung cancer. hsa_circ_0043256 hsa_circ_ACACA circ_0043256 DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "Forced expression of circ_0043256 could impede the tumorigenesis of lung cancer via miR-1206/KLF2 axis, indicating a potential therapeutic approach for lung cancer." 2 CircRNA mannosidase alpha class 1A member 2 promotes esophageal squamous cell carcinoma progression by regulating C-C chemokine ligand 5. - hsa_circ_MAN1A2 circMAN1A2 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, microarray" up-regulated "Our results suggest that circMAN1A2 can promote the progression of ESCC by regulating CCL5. Thus, circMAN1A2 might be a novel diagnostic biomarker of ESCC, and targeting circMAN1A2 using inhibitors could be a potential therapeutic strategy to treat ESCC." 1 Chemotherapy-Induced Senescence Reprogramming Promotes Nasopharyngeal Carcinoma Metastasis by circRNA-Mediated PKR Activation. hsa_circ_0000206 hsa_circ_WDR37 circWDR37 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, RNA-seq, microarray" up-regulated This study uncovers a new mechanism of circWDR37 activated PKR in senescence-driven metastasis and provides appealing therapeutic targets in NPC. 1 Circular RNA circ_0029589 promotes ox-LDL-induced endothelial cell injury through regulating RAB22A by serving as a sponge of miR-1197. hsa_circ_0029589 hsa_circ_CHFR circ_0029589 DOID:1936 atherosclerosis atherosclerosis "RT-qPCR, microarray" up-regulated "Circ_0090231 might protect against ox-LDL-mediated HUVEC injury via the miR-1197/RAB22A axis, which provides a therapeutic strategy for endothelial cell damage of AS." 6 Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis. hsa_circ_0001658 hsa_circ_ARID1B circ_0001658 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0001658 regulates the miR-590-5p/METTL 3-axis to increase CRC cell growth and decrease apoptosis. 1 Identification of an unrecognized circRNA associated with development of renal fibrosis. hsa_circ_0002158 - circRNA_0002158 DOID:0050855 renal fibrosis renal fibrosis "RT-qPCR, RNA-seq" up-regulated "CircRNA_0002158 is associated with regulating Renal fibrosis, and may contribute to ameliorating the progression of Renal fibrosis in the future." 1 "Circular RNA SMARCA5 Modulates Epithelial-Mesenchymal Transformation, Proliferation, and Metastasis of Nasopharyngeal Carcinoma Cells via microRNA-582-3p/Phosphatase and Tensin Homolog Axis." - hsa_circ_SMARCA5 circSMARCA5 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "In brief, the results of the research clarified circSMARCA5 modulated NPC cells vital movement via the miR-582-3p/PTEN molecular axis." 1 Differential Circular RNA Expression Profiles in Induced Sputum of Patients with Asthma. - hsa_circ_SORT1 has_circSORT1 DOID:2841 asthma asthma "RT-qPCR, RNA-seq" up-regulated "Differentially expressed circRNAs existed in induced sputum cells of asthma patients, among which has_circSORT1 and has_circSERPINB1 were significantly upregulated and may be involved in the process of asthma disease, which could be expected to be a potential biomarker for asthma diagnosis. In addition, a ceRNA regulatory network, has_circSORT1/has-miR-185-3p/ZNFX1, may exist in asthma." 1 Differential Circular RNA Expression Profiles in Induced Sputum of Patients with Asthma. - hsa_circ_SERPINB1 has_circSERPINB1 DOID:2841 asthma asthma "RT-qPCR, RNA-seq" up-regulated "Differentially expressed circRNAs existed in induced sputum cells of asthma patients, among which has_circSORT1 and has_circSERPINB1 were significantly upregulated and may be involved in the process of asthma disease, which could be expected to be a potential biomarker for asthma diagnosis. In addition, a ceRNA regulatory network, has_circSORT1/has-miR-185-3p/ZNFX1, may exist in asthma." 1 CircRNA Uxs1/miR-335-5p/PGF axis regulates choroidal neovascularization via the mTOR/p70 S6k pathway. - mmu_circ_Uxs1 circUxs1 DOID:11382 corneal neovascularization choroidal neovascularization RT-qPCR up-regulated "In conclusion, circRNA Uxs1 promoted CNV by sponging miR-335-5p, which stimulated PGF expression and subsequently activated the mTOR/p70 S6k pathway. Therefore, circRNA Uxs1 may serve as a promising therapeutic target for CNV." 1 A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR. hsa_circ_0001727 hsa_circ_ZKSCAN1 circZKSCAN1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "These results reveal that a novel circZKSCAN1-encoded peptide acts as a tumor suppressor on PI3K/AKT/mTOR pathway, and sensitizes HCC cells to sorafenib via ubiquitination of mTOR. These findings demonstrated that circZKSaa has the potential to serve as a therapeutic target and biomarker for HCC treatment." 3 Circ_0110498 facilitates the cisplatin resistance of non-small cell lung cancer by mediating the miR-1287-5p/RBBP4 axis. hsa_circ_0110498 hsa_circ_MAGI3 circ_0110498 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0110498 facilitated DDP resistance partly through mediating the miR-1287-5p/RBBP4 signaling in NSCLC. 2 circAR-E2E4-miR-665-STAT3 axis is a potential regulatory network in triple-negative breast cancer. - hsa_circ_AR circAR-E2E4 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "Collectively, the regulatory network circAR-E2E4-miR-665-STAT3 axis we constructed was associated with TNBC progression, providing a promising diagnostic, prognostic, and therapeutic target in future treatment for TNBC." 1 circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma. hsa_circ_0026782 hsa_circ_ITGA7 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "In all, circ_ITGA7 suppressed CRC growth and enhanced radiosensitivity by up-regulating SMAD4 through sequestering miR-766, providing an insight for the further development of CRC treatment." 4 CircRNA hsa_circ_0070659 predicts poor prognosis and promotes non-small cell lung cancer (NSCLC) progression via microRNA-377 (miR-377) / Ras-Associated Binding Protein 3C (RAB3C) pathway. hsa_circ_0070659 hsa_circ_CCDC109B - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our study revealed a novel signaling pathway that circ_0070659/miR-377/RAB3C axis regulates tumor progression, and it may become a new therapeutic target for NSCLC." 1 Circular ribonucleic acid circ-FADS2 promotes colorectal cancer cell proliferation and invasion by regulating miR-498/S100A16. - hsa_circ_FADS2 "circ-FADS2, hsa_circRNA_100833" DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated A study of the molecular mechanism suggests that a circ-FADS2/miR-498/S100A16/AKT signaling cascade may be a potential therapeutic target for the treatment of CRC. 1 Characterization of circSCL38A1 as a novel oncogene in bladder cancer via targeting ILF3/TGF-beta2 signaling axis. hsa_circ_0000396 hsa_circ_SCL38A1 circSCL38A1 DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" up-regulated "Thus, our study revealed an essential role and clinical significance of circSLC38A1 in BC via activating the transcription of TGF-beta2 in an ILF3-dependent manner, extending the understanding of the importance of circRNA-mediated transcriptional regulation in BC metastasis." 1 Circ-ATIC regulates esophageal squamous cell carcinoma growth and metastasis through miR-1294/PBX3 pathway. hsa_circ_0058063 hsa_circ_ATIC circ-ATIC DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "Collectively, circ-ATIC promoted ESCC proliferation and invasion by regulating miR-1294/PBX3 axis." 2 Exosomal circ-PTPN22 and circ-ADAMTS6 mark T cell exhaustion and neutrophil extracellular traps in Asian intrahepatic cholangiocarcinoma. hsa_circ_0110529 hsa_circ_PTPN22 circ-PTPN22 DOID:4928 intrahepatic cholangiocarcinoma asian intrahepatic cholangiocarcinoma "RT-qPCR, RNA-seq" up-regulated Our results revealed a subgroup of Asian ICC characterized by T cell exhaustion and neutrophil extracellular traps and marked by elevated levels of circ-PTPN22 and circ-ADAMTS6 in tumor tissues and plasma exosomes. 1 Exosomal circ-PTPN22 and circ-ADAMTS6 mark T cell exhaustion and neutrophil extracellular traps in Asian intrahepatic cholangiocarcinoma. hsa_circ_0072688 hsa_circ_ADAMTS6 circ-ADAMTS6 DOID:4928 intrahepatic cholangiocarcinoma asian intrahepatic cholangiocarcinoma "RT-qPCR, RNA-seq" up-regulated Our results revealed a subgroup of Asian ICC characterized by T cell exhaustion and neutrophil extracellular traps and marked by elevated levels of circ-PTPN22 and circ-ADAMTS6 in tumor tissues and plasma exosomes. 1 Circ_0044411 silencing protects infantile pneumonia from lipopolysaccharide-induced cell injury by sponging miR-141-3p to inhibit CCL16 expression. hsa_circ_0044411 hsa_circ_ZNF652 circ_0044411 DOID:10533 viral pneumonia infantile pneumonia RT-qPCR up-regulated "Circ_0044411 knockdown promoted cell viability and proliferation, inhibited inflammatory response and apoptosis by regulating miR-141-3p/CCL16 axis, indicating that circ_0044411 might be a potential therapeutic target for IP." 3 A novel circular RNA circNLRP3 alleviated ricin toxin-induced TNF-alpha production through sponging miR-221-5p. - hsa_circ_NLRP3 circNLRP3 DOID:0050117 disease by infectious agent Inflammation "RT-qPCR, RNA-seq" up-regulated "Our findings elucidated a possible mechanistic link between the circNLRP3/miR-221-5p/A20 axis and RT-induced inflammatory response, which may broaden our understanding of RT poisoning." 1 Circ_0001498 contributes to lipopolysaccharide-induced lung cell apoptosis and inflammation in sepsis-related acute lung injury via upregulating SOX6 by interacting with miR-574-5p. hsa_circ_0001498 - circ_0001498 DOID:850 lung disease acute lung injury RT-qPCR up-regulated This research identified that circ_0001498 facilitated sepsis-related ALI progression by targeting miR-574-5p to upregulate SOX6. 1 circRNA_0067717 promotes paclitaxel resistance in nasopharyngeal carcinoma by acting as a scaffold for TRIM41 and p53. hsa_circ_0067717 hsa_circ_RNF13 circRNA_0067717 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, microarray" up-regulated "We demonstrate that circRNA_0067717 acts as a scaffold for TRIM41 and p53, enhancing paclitaxel chemoresistance in NPC by promoting TRIM41-induced p53 degradation via ubiquitination." 2 circRNA432 enhances the coelomocyte phagocytosis via regulating the miR-2008-ELMO1 axis in Vibrio splendidus-challenged Apostichopus japonicus. - apo_circ_RNA432 circRNA432 DOID:0050117 disease by infectious agent coelomocytes phagocytosis RT-qPCR up-regulated These findings will enrich the regulatory mechanism of phagocytosis in echinoderm and provide theoretical data for SUS disease prevention and control in sea cucumbers. 1 Identification of pathological-related and diagnostic potential circular RNAs in Stanford type A aortic dissection. - hsa_circ_PTGR1 circPTGR1 DOID:0080685 aortic dissection Stanford type A aortic dissection "RT-qPCR, RNA-seq" up-regulated "The 4 key circRNAs, namely circPTGR1 (chr9:114341075-114348445[-]), circNOX4 (chr11:89069012-89106660[-]), circAMN1 (chr12:31854796-31862359[-]) and circUSP3 (chr15:63845913-63855207[+]), demonstrated a high power to discriminate between TAAD and control tissues, suggesting that these molecules stand for a major difference between the tissues at gene regulation level." 1 Identification of pathological-related and diagnostic potential circular RNAs in Stanford type A aortic dissection. - hsa_circ_NOX4 circNOX4 DOID:0080685 aortic dissection Stanford type A aortic dissection "RT-qPCR, RNA-seq" up-regulated "The 4 key circRNAs, namely circPTGR1 (chr9:114341075-114348445[-]), circNOX4 (chr11:89069012-89106660[-]), circAMN1 (chr12:31854796-31862359[-]) and circUSP3 (chr15:63845913-63855207[+]), demonstrated a high power to discriminate between TAAD and control tissues, suggesting that these molecules stand for a major difference between the tissues at gene regulation level." 1 Identification of pathological-related and diagnostic potential circular RNAs in Stanford type A aortic dissection. - hsa_circ_AMN1 circAMN1 DOID:0080685 aortic dissection Stanford type A aortic dissection "RT-qPCR, RNA-seq" up-regulated "The 4 key circRNAs, namely circPTGR1 (chr9:114341075-114348445[-]), circNOX4 (chr11:89069012-89106660[-]), circAMN1 (chr12:31854796-31862359[-]) and circUSP3 (chr15:63845913-63855207[+]), demonstrated a high power to discriminate between TAAD and control tissues, suggesting that these molecules stand for a major difference between the tissues at gene regulation level." 1 Identification of pathological-related and diagnostic potential circular RNAs in Stanford type A aortic dissection. - hsa_circ_USP3 circUSP3 DOID:0080685 aortic dissection Stanford type A aortic dissection "RT-qPCR, RNA-seq" up-regulated "The 4 key circRNAs, namely circPTGR1 (chr9:114341075-114348445[-]), circNOX4 (chr11:89069012-89106660[-]), circAMN1 (chr12:31854796-31862359[-]) and circUSP3 (chr15:63845913-63855207[+]), demonstrated a high power to discriminate between TAAD and control tissues, suggesting that these molecules stand for a major difference between the tissues at gene regulation level." 1 "Hsa_circ_0072765 knockdown inhibits proliferation, activation and migration in transforming growth factor-beta (TGF-beta)-induced hepatic stellate cells (HSCs) by the miR-197-3p/TRPV3 axis." hsa_circ_0072765 hsa_circ_CCNB1 circ_0072765 DOID:409 liver disease liver fibrosis RT-qPCR up-regulated Hsa_circ_0072765 promoted the progression of TGF-beta-treated HSCs by decoying miR-197-3p and upregulating TRPV3. 2 Splicing factor SNRPA associated with microvascular invasion promotes hepatocellular carcinoma metastasis through activating NOTCH1/Snail pathway and is mediated by circSEC62/miR-625-5p axis. hsa_circ_0001358 hsa_circ_SEC62 circSEC62 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Taking these results together, our study identified a novel regulatory mechanism among SNRPA, miR-625-5p, circSEC62 and the NOTCH1/Snail pathway in HCC, which promoted metastasis of HCC and may provide effective suggestions for improving the prognosis of HCC patients with metastasis." 1 Hsa_circ_0119412 Contributes to Development of Retinoblastoma by Targeting miR-186-5p/ELK4 Axis. hsa_circ_0119412 hsa_circ_PER2 circ_0119412 DOID:768 retinoblastoma retinoblastoma RT-qPCR up-regulated "Circ_0119412 was found to be upregulated in RB, and could accelerate the progression of RB via the miR-186-5p/ELK4 axis, indicating circ_0119412 may serve a promising clinical therapeutic target of RB." 1 Circ_0006667 contributes to high glucose-induced retinal pigment epithelial cell dysfunction by mediating miR-7-5p/TGFA axis in diabetic retinopathy. hsa_circ_0006667 - circ_0006667 DOID:8947 diabetic retinopathy Diabetic retinopathy RT-qPCR up-regulated Circ_0006667 silencing protected ARPE-19 cells from HG-induced dysfunction by mediating miR-7-5p/TGFA axis. 1 Circ-calm4 regulates hypoxia-induced pulmonary artery smooth muscle autophagy by binding Purb. - mmu_circ_calm4 circ-calm4 DOID:850 lung disease hypoxia-induced pulmonary artery smooth muscle autophagy RT-qPCR up-regulated "Overall, our results confirm that the circ-calm4/Purb/Beclin1 signal axis is involved in the occurrence of hypoxia-induced PASMCs autophagy, and the novel regulatory mechanisms and signals transduction pathways in PASMC autophagy induced by hypoxia." 1 Circular hsa_circ_0020377 regulates KLF7 by targeting miR-194-5p to facilitate tumor cell malignant behaviors and glycolysis in oral squamous cell carcinoma progression. hsa_circ_0020377 hsa_circ_ADAM12 - DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated These results broaden our insights regarding the regulation of OSCC progression via circRNA and act as a reference for future clinical studies in OSCC diagnosis and treatment. 1 FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. - mmu_circ_SCMH1 circSCMH1 DOID:6713 cerebrovascular disease stroke RT-qPCR up-regulated "Our data demonstrate that circSCMH1 enhances vascular repair via FTO-regulated m(6)A methylation after stroke, providing insights into the mechanism of circSCMH1 in promoting stroke recovery." 1 "Circular RNA PVT1 Regulates Cell Proliferation, Migration, and Apoptosis by Stabilizing c-Myc and Downstream Target CXCR4 Expression in Acute Myeloid Leukemia." - hsa_circ_PVT1 circPVT1 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated Our findings showed that circPVT1 was highly expressed in AML patients and was related to shorter OS and RFS. CircPVT1 may exert an oncogenic effect in THP-1 cells by stabilizing c-Myc protein expression and downstream target CXCR4 expression. 2 circRNA-SMO upregulates CEP85 to promote proliferation and migration of glioblastoma via sponging miR-326. hsa_circ_0001742 hsa_circ_SMO circRNA-SMO DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "CircRNA-SMO sponges miR-326 to promote glioblastoma proliferation and migration by upregulating CEP85 expression. This study clarified the role of circRNA-SMO in the development of glioblastoma, providing novel insights for its treatment." 1 Dexmedetomidine promotes ferroptotic cell death in gastric cancer via hsa_circ_0008035/miR-302a/E2F7 axis. hsa_circ_0008035 hsa_circ_EXT1 circ_0008035 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Taken together, DEX mediated ferroptotic cell death in GC through regulating the circ0008035/miR-302a/E2F7 axis, suggesting a feasible therapy option for GC." 4 CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis. hsa_circ_0000118 hsa_circ_MAN1A2 circ_0000118 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Our study suggested that circ_0000118 functions as an oncogenic factor in progression of CC by maintaining AKT2 level through targeting miR-211-5p and miR-377-3p as a ceRNA (competitive endogenous RNA), which provides novel therapeutic target in the management of CC." 2 Exosome-transmitted circIFNGR2 Modulates Ovarian Cancer Metastasis via miR-378/ST5 Axis. hsa_circ_0001185 hsa_circ_IFNGR2 circIFNGR2 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated Our study revealed a previously unknown regulatory pathway whereby CAFs-derived exosomes delivered circIFNGR2 and inhibited the malignant progression of OVCA by circIFNGR2/miR-378/ST5 axis. 1 Human umbilical cord mesenchymal stem cells-derived exosomal circDLGAP4 promotes angiogenesis after cerebral ischemia-reperfusion injury by regulating miR-320/KLF5 axis. - hsa_circ_DLGAP4 circDLGAP4 DOID:2316 brain ischemia cerebral ischemia/reperfusion injury RT-qPCR up-regulated hUC-MSCs-Exos-derived circDLGAP4 reduced cerebrovascular injury by regulating miR-320/KLF5 signaling. These results provide a stem cell-based approach to treat CIRI. 2 Circ_0001312 Silencing Suppresses Doxorubicin-Induced Cardiotoxicity via MiR-409-3p/HMGB1 Axis. hsa_circ_0001312 - circ_0001312 DOID:1287 cardiovascular system disease cardiotoxicity RT-qPCR up-regulated circ_0001312 was secreted by exosomes and could be transmitted via exosomes.Circ_0001312 reversed the cytotoxic effects mediated by DOX on cardiomyocytes via the miR-409-3p/HMGB1 axis. 1 Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis. - hsa_circ_SMARCA5 circRNA SMARCA5 DOID:4947 cholangiocarcinoma cholangiocarcinoma RT-qPCR down-regulated CircRNA SMARCA5 is involved in CHOL development by interosculating miRNA-95-3p/TRAF3 axis and may become a novel approach for treating CHOL. 1 Circ_0091537 promotes gefitinib chemoresistance in non-small cell lung cancer by mediating the miR-520h/YAP1 network. hsa_circ_0091537 hsa_circ_LOC286467 circ_0091537 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0091537 strengthens gefitinib chemoresistance to promote NSCLC progression by mediating the miR-520h/YAP1 network, suggesting that circ_0091537 may be a key indicator in resistance to treatment of NSCLC." 1 Circular RNA circ_0005667 promotes cisplatin resistance of endometrial carcinoma cells by regulating IGF2BP1 through miR-145-5p. hsa_circ_0005667 hsa_circ_ZNF124 circ_0005667 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated Circ_0005667 enhanced DDP resistance in EC by elevating IGF2BP1 through sponging miR-145-5p. 2 Circular RNA circ_0000212 accelerates cervical cancer progression by acting as a miR-625-5p sponge to upregulate PTP4A1. hsa_circ_0000212 hsa_circ_SFMBT2 circ_0000212 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "circ_0000212 acted as an oncogene in cervical cancer progression, and knockdown of circ_0000212 repressed cervical cancer development by increasing miR-625-5p and decreasing PTP4A1." 3 CircSETDB1 contributes to paclitaxel resistance of ovarian cancer cells by sponging miR-508-3p and regulating ABCC1 expression. - hsa_circ_SETDB1 circSETDB1 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "In conclusion, circSETDB1 regulated Ptx resistance of ovarian cancer by targeting miR-508-3p/ ABCC1 axis." 3 Circ_0058063 regulates the development of esophageal cancer through miR-377-3p/HOXA1 axis. hsa_circ_0058063 hsa_circ_ATIC circ_0058063 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "Our study found that circ_0058063 could regulate the expression of HOXA1 by targeting miR-377-3p, thereby affecting the progress of esophageal cancer." 1 Circular RNA circ_0003028 regulates cell development through modulating miR-498/ornithine decarboxylase 1 axis in hepatocellular carcinoma. hsa_circ_0003028 hsa_circ_FUT8 circ_0003028 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "In brief, the results demonstrated that circ_0003028 exerted tumourigenicity roles via miR-498/ODC1 signaling axis, providing a promising biomarker and therapeutic target for HCC." 2 CircBNC2 affects epithelial ovarian cancer progression through the miR-223-3p/ LARP4 axis. - hsa_circ_BNC2 circBNC2 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "Overexpression of circBNC2 decreased proliferation, migration, and invasion of EOC cells by regulating the miR-223-3p/ LARP4 axis, suggesting that circBNC2/miR-223-3p/ LARP4 axis may be a potential regulatory mechanism for the treatment of EOC." 2 CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma. - hsa_circ_POLA2 - DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated Circ_POLA2 is overexpressed in MCL and might promote GBM cell apoptosis through downregulating PTEN. 1 Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in ovarian cancer by miR-942-5p/NFIB axis. - hsa_circ_PIP5K1A circ-PIP5K1A DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Besides that, circ-PIP5K1A was packaged into exosomes and exosomal circ-SKA3 could mediate intercellular communication between OC cells. These findings provided a promising therapeutic target for OC." 2 circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR. - hsa_circ_IPO7 circIPO7 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated "Thus, the complex containing overexpressed circIPO7 blocked the caprin-1-G3BP1 interaction and dissociated caprin-1 and its target mRNAs (EGFR and mTOR) from ribosomes, resulting in their translational inhibition, followed by PI3K/AKT/mTOR pathway inactivation. " 1 Circular RNA circ_0026218 Suppressed Atherosclerosis Progression via miR-338-3p/SIRT6 Axis. hsa_circ_0026218 hsa_circ_CERS5 circ_0026218 DOID:1936 atherosclerosis atherosclerosis RT-qPCR down-regulated "Collectively, circ_0026218 upregulates SIRT6 expression through decoying miR-338-3p, thereby inhibiting ox-LDL-initiated injury of HUVECs. circ_0026218 is involved in the pathogenesis of AS." 2 Investigation of the clinicopathological and prognostic role of circMTO1 in multiple cancers. - hsa_circ_MTO1 circMTO1 DOID:162 cancer cancer RT-qPCR up-regulated "The low expression of circMTO1 may predict big tumor size, poor differentiation and worse outcome of cancer, presenting that circMTO1 may be a useful biomarker for prognosis of tumors." 1 circ_0013613 Promotes the recovery of spinal cord injury by regulating mir-370-3p/caspase1 to regulate neuronal pyroptosis. hsa_circ_0013613 hsa_circ_AP4B1 circ_0013613 DOID:319 spinal cord disease spinal cord injury RT-qPCR up-regulated circ_0013613 can promote the recovery of SCI by regulating miR-370-3p/CASP1 to mediate neuronal pyroptosis. 1 Circ_0003340 regulates the expression of ENAH to affect the development of esophageal cancer through miR-874-3p. hsa_circ_0003340 hsa_circ_OGDH - DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "The data demonstrated that circ_0003340 promoted the progression of esophageal cancer through miR-874-3p/ENAH axis, which might provide novel therapeutic targets for esophageal cancer intervention." 3 Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis. hsa_circ_0000285 hsa_circ_HIPK3 circ_0000285 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated Circ_0000285 upregulates FNDC3B expression by adsorbing miR-1278 to promote NPC development. 3 CircKRT14 upregulates E2F3 by interacting with miR-1256 to act as an oncogenic factor in esophageal cancer. - hsa_circ_KRT14 circKRT14 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated These results uncovered that circKRT14 up-regulated the expression of E2F3 and promoted the malignant development of EC through sponging miR-1256. 1 Circular RNA 0001789 sponges miR-140-3p and regulates PAK2 to promote the progression of gastric cancer. hsa_circ_0001789 hsa_circ_RAB11FIP1 circ_0001789 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "The present data suggested that the upregulation of circ_0001789 was associated with the progression of GC and with poor prognosis in patients with GC, and that miR-140-3p/PAK2 served as the downstream axis to mediate the oncogenic effect of circ_0001789." 2 circANKRD28 inhibits cisplatin resistance in non-small-cell lung cancer through the miR-221-3p/SOCS3 axis. - hsa_circ_ANKRD28 circANKRD28 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "The present study revealed the regulatory effects and molecular mechanism of circANKRD28 on the development and cisplatin resistance in NSCLC, which may provide experimental basis and theoretical support to identify new targets for therapy of DDP resistance in NSCLC." 1 Hsa_circ_0063329 inhibits prostate cancer growth and metastasis by modulating the miR-605-5p/tgif2 axis. hsa_circ_0063329 hsa_circ_DDX17 circ_0063329 DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated "In conclusion, hsa_circ_0063329 inhibits the proliferation and metastasis of PCa via modulation of the miR-605-5p/TGIF2 axis, and targeting hsa_circ_0063329 may provide a promising treatment strategy for aggressive PCa." 2 Circ_TEX2 Functions as a Tumor Suppressor in Hepatoma via miR-96-5p/SPRED1 Axis. hsa_circ_0004913 hsa_circ_TEX2 "circ_TEX2, circ_0004913" DOID:684 hepatocellular carcinoma hepatoma RT-qPCR down-regulated "Our study demonstrates the tumor-suppressive role of circ_TEX2 in hepatoma through miR-96-5p/SPRED1 axis, suggesting that strategies directed toward restoring the production of circ_TEX2 might have a therapeutic value for hepatoma treatment." 3 HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway. hsa_circ_0001535 hsa_circ_FAM13B circFAM13B DOID:11054 urinary bladder cancer bladder cancer "RT-qPCR, RNA-seq" down-regulated "HNRNPL-induced circFAM13B could repress immune evasion and enhance immunotherapy sensitivity by inhibiting glycolysis and acidic TME in BCa through the novel circFAM13B/IGF2BP1/PKM2 cascade. Therefore, circFAM13B can be used as a biomarker for guiding the immunotherapy among patients with BCa." 1 Hypoxia-associated circPRDM4 promotes immune escape via HIF-1alpha regulation of PD-L1 in hepatocellular carcinoma. hsa_circ_0007468 hsa_circ_PRDM4 circPRDM4 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, RNA-seq" up-regulated "These findings illustrated that circPRDM4 promoted immune escape of HCC cells by facilitating the recruitment of HIF-1alpha onto the promoter of CD274 under hypoxia, thereby inhibiting CD8+ T cell infiltration in the tumor microenvironment." 1 circ_rac GTPase-Activating Protein 1 Facilitates Stemness and Metastasis of Non-Small Cell Lung Cancer via Polypyrimidine Tract-Binding Protein 1 Recruitment to Promote Sirtuin-3-Mediated Replication Timing Regulatory Factor 1 Deacetylation. - hsa_circ_RACGAP1 circRACGAP1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Our results uncover a novel regulatory mechanism of circRACGAP1 in NSCLC and identify circRACGAP1 as a promising therapeutic target. 2 Hsa_circ_0001925 promotes malignant progression in triple-negative breast cancer via miR-1299/YY1 axis. hsa_circ_0001925 hsa_circ_KIF4A circ_0001925 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Our findings showed that hsa_circ_0001925 mediated TNBC progression via regulating miR-1299/YY1 axis, providing a potential target for BC treatment." 4 Circ_0024108 promotes the progression of esophageal cancer cells. hsa_circ_0024108 hsa_circ_MMP1 circ_0024108 DOID:5041 esophageal cancer esophageal cancer RT-qPCR up-regulated "Taken together, circ_0024108 participated in the progress of ESCC through the miR-488-3p/USP14 axis. Circ_0024108 was differentially expressed in serum exosomes. Circ_0024108 might be a potential biomarker for the diagnosis of ESCC." 1 Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis. hsa_circ_0009158 hsa_circ_ASPH circASPH DOID:409 liver disease hepatic fibrosis RT-qPCR up-regulated "Thus, downregulation of circASPH may suppress the activation of HSCs and HF through the circASPH/miR-139-5p/Notch1 axis. Our findings indicated that circASPH may be a potential biomarker for HF diagnosis and therapy." 1 circ_0001274 Competitively Binds miR-143-3p to Upregulate VWF Expression to Improve Acute Traumatic Coagulopathy. hsa_circ_0001274 hsa_circ_PLCL2 circ_0001274 DOID:1247 blood coagulation disease acute traumatic coagulopathy "RT-qPCR, RNA-seq" up-regulated Our study highlights the critical role of circ_0001274/miR-143-3p/VWF axis in improving ATC. 1 Propofol-mediated circ_0000735 downregulation restrains tumor growth by decreasing integrin-beta1 expression in non-small cell lung cancer. hsa_circ_0000735 hsa_circ_P2RX1 circ_0000735 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "In conclusion, propofol restrained NSCLC growth by downregulating circ_0000735, which functioned as a miR-153-3p sponge and regulated ITGB1 expression via adsorbing miR-153-3p. This study provides evidence to support that propofol curbs NSCLC progression by regulating circRNA expression." 4 Silencing of circ_002136 sensitizes gastric cancer to paclitaxel by targeting the miR-16-5p/HMGA1 axis. hsa_circ_0000005 hsa_circ_CDK11A circ_002136 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Overall, our study revealed a novel signaling pathway that could be used for future clinical applications, namely the circ_002136/miR-16-5p/HMGA1 axis to regulate the Tax resistance of GC cells." 1 Circ_0084188 Regulates the progression of colorectal cancer through the miR-769-5p/KIF20A axis. hsa_circ_0084188 hsa_circ_KIAA0146 circ_0084188 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0084188 upregulated the expression of KIF20A to promote the tumorigenesis of CRC through miR-769-5p, providing a new therapeutic target for CRC." 1 Hsa_circ_0017956 Acts as miR-758-3p Sponge to Facilitate the Progression of Non-small-Cell Lung Cancer by Regulating FOXP4 Expression. hsa_circ_0017956 hsa_circ_MLLT10 circ_0017956 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Altogether, circ_0017956 promoted the progression of NSCLC by regulating FOXP4 through sponging miR-758-3p." 2 Circ_0108942 Regulates the Progression of Breast Cancer by Regulating the MiR-1178-3p/TMED3 Axis. hsa_circ_0108942 hsa_circ_ANKRD12 circ_0108942 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0108942 boosted BC progression by regulating miR-1178-3p and thus upregulating TMED3. 3 circITGB1 Regulates Adipocyte Proliferation and Differentiation via the miR-23a/ARRB1 Pathway. - oar_circ_ITGB1 circITGB1 DOID:9970 obesity obesity RT-qPCR up-regulated we provide evidence that circITGB1 regulates the proliferation and differentiation of sheep adipocytes via the miR-23a/ARRB1 pathway. This study provides a scientific basis for further studies on adipose tissue development at the circRNA level. 1 Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro. - hsa_circ_SCRG1 circSCRG1 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "In conclusion, circSCRG1 might serve as a new target regulating angiogenesis in atherosclerosis via the circSCRG1/miR-1268b/NR4A1 axis." 1 Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A. hsa_circ_0008832 hsa_circ_FBXO7 circFBXO7 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircFBXO7 acts as a tumor suppressor by a novel circFBXO7/miR-296-3p/KLF15/CDKN1A axis, which may serve as a potential biomarker and therapeutic target for NSCLC." 1 The circular RNA circHelz enhances cardiac fibrosis by facilitating the nuclear translocation of YAP1. mmu_circ_0000332 mmu_circ_Helz circHelz DOID:114 heart disease cardiac fibrosis RT-qPCR up-regulated "Collectively, the protective effect of circHelz knockdown against cardiac fibrosis injury is accomplished by inhibiting the nuclear translocation of YAP1. Thus, circHelz may be a novel target for the prevention and treatment of cardiovascular disease." 1 Circular RNA circFAT1(e2) Facilitates Cell Progression through the miR-30e-5P/MYBL2 Pathway in Glioma. hsa_circ_0001461 hsa_circ_FAT1 circFAT1(e2) DOID:0060108 brain glioma glioma RT-qPCR up-regulated "circFAT1(e2) could promote glioma development by regulating MYBL2 and miR-30e-5p, and MYBL2 has diagnostic and prognostic values in glioma." 1 Expression profiling of circular RNA reveals a potential miR-145-5p sponge function of circ-AFF2 and circ-ASAP1 in renal cell carcinoma. hsa_circ_0008934 hsa_circ_ASAP1 circ-ASAP1 DOID:4450 renal cell carcinoma renal cell carcinoma "RT-qPCR, RNA-seq" up-regulated circ-AFF2 and circ-ASAP1 were upregulated in RCC and likely promote tumor progression by sponging miR-145. 1 Expression profiling of circular RNA reveals a potential miR-145-5p sponge function of circ-AFF2 and circ-ASAP1 in renal cell carcinoma. hsa_circ_0001947 hsa_circ_AFF2 circ-AFF2 DOID:4450 renal cell carcinoma renal cell carcinoma "RT-qPCR, RNA-seq" up-regulated circ-AFF2 and circ-ASAP1 were upregulated in RCC and likely promote tumor progression by sponging miR-145. 1 CircRNA_0263 and circRNA_1507 are dysregulated in a rat model of atrial fibrosis induced by chronic intermittent hypoxia. - - circRNA_0263 DOID:114 heart disease atrial fibrosis RT-qPCR up-regulated "Among the dysregulated circRNAs, circRNA_0263 and circRNA_1507 were the most upregulated and most downregulated circRNAs, respectively." 1 CircRNA_0263 and circRNA_1507 are dysregulated in a rat model of atrial fibrosis induced by chronic intermittent hypoxia. - - circRNA_1507 DOID:114 heart disease atrial fibrosis RT-qPCR down-regulated "Among the dysregulated circRNAs, circRNA_0263 and circRNA_1507 were the most upregulated and most downregulated circRNAs, respectively." 1 The Effects of circ_000558/miR-1225-5p/ARL4C on Regulating the Proliferation of Renal Cell Carcinoma Cells. hsa_circ_0000025 hsa_circ_EIF4G3 circ_000558 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "Overall, our study suggested that circ_000558/miR-1225-5p/ARL4C network was related to the RCC cell proliferation." 1 Circ_0124208 Promotes the Progression of Hepatocellular Carcinoma by Regulating the miR-338-3p/LAMC1 Axis. hsa_circ_0124208 hsa_circ_TKT circ_0124208 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated the circ_0124208/miR-338-3p/LAMC1 axis can be used as a potential therapeutic target for HCC treatment. 1 Circ_0115118 regulates endometrial functions through the miR-138-1-3p/WDFY2 axis in patients with PCOS. hsa_circ_0115118 hsa_circ_SAMHD1 circ_0115118 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RT-qPCR up-regulated Our findings reveal that circ_0115118 may be a potential therapeutic target to improve pregnancy outcomes in women with PCOS. 1 Circ_0000566 contributes oxygen-glucose deprivation and reoxygenation (OGD/R)-induced human brain microvascular endothelial cell injury via regulating miR-18a-5p/ACVR2B axis. hsa_circ_0000566 hsa_circ_VRK1 circ_0000566 DOID:178 vascular disease microvascular endothelial cell injury RT-qPCR up-regulated Circ_0000566 sponged miR-18a-5p to regulate OGD/R-induced HBMECs injury via regulating ACVR2B expression. 1 m(6)A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m(6)A/PD-L1 manner. hsa_circ_0041234 hsa_circ_MYO1C circMYO1C DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" up-regulated "In conclusion, these findings highlight the oncogenic role of METTL3-induced circMYO1C in PDAC tumorigenesis via an m6A-dependent manner, inspiring a novel strategy to explore PDAC epigenetic therapy." 1 CircADSS contributes to hepatocellular carcinoma development by regulating miR-431-5p/TOP2A. - hsa_circ_ADSS circADSS DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated CircADSS could regulate HCC cell malignancy by miR-431-5p/TOP2A axis. 2 CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling. - hsa_circ_FOXP1 circFOXP1 DOID:2316 brain ischemia acute ischemic stroke RT-qPCR down-regulated "In summary, our study is the first to reveal that circFOXP1 alleviates brain injury after cerebral ischemia by regulating STAT3/apoptotic signaling, which provides a potentially novel therapeutic target for AIS." 1 The Circular RNA Circ_0085494 Regulates Prostate Cancer Progression Through NRBP1/miR-497-5p Axis. hsa_circ_0085494 hsa_circ_TMEM65 circ_0085494 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated Our finding revealed that circ_0085494 downregulation might repress PCa tumor progression through in part regulating the miR-497-5p/NRBP1 pathway. 1 The malignancy of chordomas is enhanced via a circTLK1/miR-16-5p/Smad3 positive feedback axis. hsa_circ_0057021 hsa_circ_TLK1 circTLK1 DOID:3302 chordoma chordomas RT-qPCR up-regulated "Taken together, our findings suggested that the disruption of the circTLK1/miR-16-5p/Smad3 positive feedback pathway, particularly via the Smad3 inhibitor SIS3, could be a promising therapeutic strategy." 1 Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway. hsa_circ_0034952 hsa_circ_TUBGCP4 circTUBGCP4 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "Our results suggest that colorectal cancer cells generate exosomal circTUBGCP4, which causes vascular endothelial cell tipping to promote angiogenesis and tumor metastasis by activating Akt signaling pathway." 1 "circPKD2 inhibits the glioma cell proliferation, invasion and glycolytic metabolism through regulating the miR-1278/LATS2 axis." hsa_circ_0070401 hsa_circ_PKD2 circPKD2 DOID:0060108 brain glioma glioma RT-qPCR down-regulated These findings display that circPKD2 can function as a tumor suppressor in glioma by controlling the miR-1278/LATS2 axis and provide the potential biomarkers for glioma treatment. 1 Hypoxic glioma cell-secreted exosomal circ101491 promotes the progression of glioma by regulating miR-125b-5p/EDN1. - - circ101491 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "In summary, hypoxia could promote circ101491 overexpression in glioma cell-derived exosomes, and circ101491/miR-125b-5p/EDN1 regulatory axis might be implicated in the malignant progression of glioma." 1 Hsa_circ_0128846 knockdown attenuates the progression of pancreatic cancer by targeting miR-1270/NR3C1 axis. hsa_circ_0128846 hsa_circ_ZFR circ_0128846 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "Circ_0128846 deficiency blocked PC progression via mediating the miR-1270/NR3C1 pathway, which partly illustrated PC pathogenesis." 2 Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-kB-IL-6 axis of tumor-associated macrophages. hsa_circ_0001103 hsa_circ_SERPINE2 cSERPINE2 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Our study illustrates a novel mechanism that tumor exosomal cSERPINE2 mediates a positive feedback loop between tumor cells and TAMs to promote cancer progression, which may serve as a promising nanotherapeutic strategy for the treatment of breast cancer." 1 Downregulation of circPPFIA1 elevates radiosensitivity via miR-1299-mediated TXNRD1 inhibition in esophageal squamous cell carcinoma. - hsa_circ_PPFIA1 circPPFIA1 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated All experimental data showed that knockdown of circPPFIA1 contributed to radiosensitivity in ESCC by inducing miR-1299-related downregulation of TXNRD1. 2 hsa_circ_0000021 sponges miR-3940-3p/KPNA2 expression to promote cervical cancer progression. hsa_circ_0000021 hsa_circ_PLEKHM2 circ_0000021 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Hsa_circ_0000021 regulates the miR-3940-3p/KPNA2 axis to promote CC occurrence. This potentially is a novel target for CC treatment. 1 Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1. - hsa_circ_METTL9 circMETTL9 DOID:81292 traumatic brain injury traumatic brain injury "RT-qPCR, RNA-seq" up-regulated "Altogether, we are the first to propose that circMETTL9 is a master regulator of neuroinflammation following TBI, and thus a major contributor to neurodegeneration and neurological dysfunction." 1 Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia-reperfusion injury. hsa_circ_0023461 hsa_circ_ARAP1 circARAP1 DOID:1287 cardiovascular system disease myocardial ischemia-reperfusion injury "RT-qPCR, microarray" up-regulated gain-of-function assays revealed that circARAP1 aggravated MI/RI in mice and H/R-induced cardiomyocyte injury by regulating the miR-379-5p/KLF9 axis to activate Wnt/beta-catenin signaling. 1 CircFNDC3B regulates osteoarthritis and oxidative stress by targeting miR-525-5p/HO-1 axis. hsa_circ_0001361 hsa_circ_FNDC3B circFNDC3B DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "In summary, we identified a new circFNDC3B/miR-525-5p/HO-1 signaling pathway that may act to relieve OA by alleviating oxidative stress and regulating the NF-¦ĘB pathway, resulting in the protection of the ECM in human chondrocytes, highlighting it as a potential therapeutic target for the treatment of OA." 1 Hypoxia-Induced FUS-circTBC1D14 Stress Granules Promote Autophagy in TNBC. - hsa_circ_TBC1D14 circTBC1D14 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "Overall, these findings reveal that circTBC1D14 is a potential prognostic indicator that can serve as a therapeutic target for TNBC treatment." 1 Hsa_circ_0137652 Regulates miR-1205/CCNB1 Axis to Accelerate the Malignancy of Breast Cancer. hsa_circ_0137652 hsa_circ_RAD23B circ_0137652 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0137652 controls the miR-1205/CCNB1 axis to induce increased breast cancer malignancy. 1 Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the Progression of Non-small Cell Lung Cancer via Upregulating the Level of FGF5. hsa_circ_0001715 hsa_circ_LIMK1 circ_0001715 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated The current evidence elucidated that circ_0001715 served as an oncogenic regulator in NSCLC progression by depending on the miR-1249-3p/FGF5 axis. 1 Circ_0000182 promotes cholesterol synthesis and proliferation of stomach adenocarcinoma cells by targeting miR-579-3p/SQLE axis. hsa_circ_0000182 hsa_circ_FLVCR1 circ_0000182 DOID:3717 gastric adenocarcinoma stomach adenocarcinoma RT-qPCR up-regulated Circ_0000182 promotes cholesterol synthesis and proliferation of STAD cells by enhancing SQLE expression via sponging miR-579-3p. 1 Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR-194-5p and elevating HK2 expression. hsa_circ_0000591 hsa_circ_MGA circ_0000591 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated circ_0000591 regulated HK2 expression by serving as a miR-194-5p molecular sponge. 1 "CircHSPG2 knockdown attenuates hypoxia-induced apoptosis, inflammation, and oxidative stress in human AC16 cardiomyocytes by regulating the miR-1184/MAP3K2 axis." - hsa_circ_HSPG2 circHSPG2 DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR up-regulated CircHSPG2 knockdown protected AC16 cells from hypoxia-induced injury by regulating the miR-1184/MAP3K2 cascade. 1 Circ_0001667 accelerates breast cancer proliferation and angiogenesis through regulating CXCL10 expression by sponging miR-6838-5p. hsa_circ_0001667 hsa_circ_HEATR2 circ_0001667 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0001667 is involved in breast cancer cell proliferation and angiogenesis through regulation of the miR-6838-5p/CXCL10 axis. 4 circFNDC3B Accelerates Vasculature Formation and Metastasis in Oral Squamous Cell Carcinoma. hsa_circ_0001361 hsa_circ_FNDC3B circFNDC3B DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "Overall, these findings uncovered the mechanistic role of circFNDC3B in orchestrating cancer cell metastatic properties and vasculature formation, suggesting circFNDC3B could be a potential target to reduce OSCC metastasis." 1 circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway. hsa_circ_0000376 hsa_circ_PRH1-PRR4 circ_0000376 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Collectively, circ_0000376 regulated NSCLC cell tumor properties by the miR-545-3p/PDPK1 axis, suggesting that circ_0000376 could be employed as a therapeutic target for NSCLC." 4 Circ_0068631 sponges miR-139-5p to promote the growth and metastasis of cutaneous squamous cell carcinoma by upregulating HOXB7. hsa_circ_0068631 hsa_circ_TFRC circ_0068631 DOID:3151 skin squamous cell carcinoma cutaneous squamous cell carcinoma RT-qPCR up-regulated "Circ_0068631 functioned as a novel oncogene in CSCC progression by regulating miR-139-5p/HOXB7 axis, suggesting that circ_0068631 may be a potential target for CSCC treatment." 1 CircRTN1 stimulates HMGB1 to regulate the malignant progression of papillary thyroid cancer by sponging miR-101-3p. hsa_circ_0102272 hsa_circ_RTN1 circRTN1 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "CircRTN1 depletion impeded PTC cell malignancy via the miR-101-3p/HMGB1 pathway, which provided a possible circRNA-targeted therapeutic strategy for PTC." 3 Hsa_circ_0046430 promotes the progression of colorectal cancer by targeting miR-6785-5p/SRCIN1 axis as a ceRNA. hsa_circ_0046430 hsa_circ_FOXK2 circ_0046430 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq, microarray" up-regulated "Our study identified and primarily validated the hsa_circ_0046430/miR-6785-5p/SRCIN1 regulatory axis impacted on CRC prognosis, suggesting novel biomarkers and therapeutic targets for CRC patients." 1 Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1. mmu_circ_0001468 mmu_circ_HIPK2 circHIPK2 DOID:3431 cerebritis lipopolysaccharide-induced astrocytic inflammation RT-qPCR up-regulated These results implied that autophagy inducer rapamycin could suppress astrocytic inflammation by inactivating circHIPK2-SIGMAR1 axis. 1 N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2. hsa_circ_0007101 hsa_circ_SAV1 circSAV1 DOID:3083 chronic obstructive pulmonary disease chronic obstructive pulmonary disease "RT-qPCR, RNA-seq" up-regulated "In lung epithelial cell, m6A-modified circSAV1, via recruiting YTHDF1, induces the formation of a circSAV1/YTHDF1/IREB2 mRNA protein ternary complex, which promotes translation of IREB2 mRNA." 1 CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis. hsa_circ_0017076 hsa_circ_GNG4 circRNA_0017076 DOID:0050855 renal fibrosis renal interstitial fibrosis RT-qPCR up-regulated "we identified circRNA_0017076 as a sponge for miR-185-5p, which regulates STIM1 gene expression and is involved in RIF." 1 A Meaningful Strategy for Glioma Diagnosis via Independent Determination of hsa_circ_0004214. hsa_circ_0004214 hsa_circ_AMOTL1 circ_0004214. DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Hsa_circ_0004 214 plays an important role in glioma, its expression level is a promising diagnostic marker for this malignancy." 2 CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR-431/SLC7A11 axis. hsa_circ_0000069 hsa_circ_STIL circSTIL DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "CircSTIL promotes CRC cell proliferation and suppresses ferroptosis in vitro via miR-431/SLC7A11 signaling, revealing the pathogenesis of CRC, and providing potential therapeutic targets of CRC." 4 CircDHRS3 inhibits prostate cancer cell proliferation and metastasis through the circDHRS3/miR-421/MEIS2 axis. hsa_circ_0010023 hsa_circ_DHRS3 circDHRS3 DOID:10283 prostate cancer prostate cancer "RT-qPCR, RNA-seq" down-regulated Our study indicates that circDHRS3 inhibits prostate cancer cell proliferation and metastasis through the circDHRS3/miR-421/MEIS2 axis. 1 "A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression." hsa_circ_0069382 hsa_circ_TBC1D19 - DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Our study also included bioinformatics analyses which determined that the high expression of hsa_circ_0069382 regulated the BTG anti-proliferation factor 2 (BTG2)/ focal adhesion kinase (FAK) axis in gastric cancer lines by sponging for miR-15a-5p. 1 Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury. - hsa_circ_HIPK3 circHIPK3 DOID:3021 acute kidney failure Acute kidney injury RT-qPCR up-regulated "In conclusion, circHIPK3 knockdown alleviated oxidative stress and apoptosis and inhibited inflammation in AKI via miR-93-5p-mediated downregulation of the KLF9 signal pathway." 2 ALKBH5-induced circular RNA NRIP1 promotes glycolysis in thyroid cancer cells by targeting PKM2. hsa_circ_0004771 hsa_circ_NRIP1 circNRIP1 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "Therefore, circNRIP1 can be a prognostic biomarker and therapeutic target for PTC by acting as a sponge for oncogenic miR-541-5p and miR-3064-5p to upregulate PKM2 expression." 1 Hsa_circ_0072309 is a prognostic biomarker and is correlated with immune infiltration in gastric cancer. hsa_circ_0072309 hsa_circ_LIFR circ_0072309 DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq, microarray" down-regulated "Hsa_circ_0072309 is a potential diagnostic biomarker for GC, and complement component 7 may be a tumor suppressor. These may potentially predict the prognosis of patients with GC and may become new therapeutic targets." 2 Hsa_circ_0070440 promotes lung adenocarcinoma progression by SLC7A11-mediated-ferroptosis. hsa_circ_0070440 hsa_circ_FAM13A circ_0070440 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "Circ_0070440 modulated LUAD malignant progression and ferroptosis via targeting SLC7A11, implying a significant role of the circ_0070440/miR-485-5p/SLC7A11 axis in the diagnosis and treatment of LUAD." 1 CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma. hsa_circ_0002316 hsa_circ_OMA1 circOMA1 DOID:5394 prolactinoma prolactinoma RT-qPCR up-regulated The present study demonstrates that circOMA1 attenuates CAB efficacy through ferroptosis resistance and may be a new therapeutic target for the individualized treatment of DA-resistant prolactinoma patients. 1 Proangiogenic role of circRNA-007371 in liver fibrosis. - hsa_circ_Stag1 circRNA-007371 DOID:409 liver disease liver fibrosis "RT-qPCR, RNA-seq, microarray" up-regulated "In conclusion, circRNA-007371 enhances angiogenesis via a miRNA sponge mechanism in liver fibrosis." 1 Has_circ_0071803 promotes colorectal cancer progression by regulating miR-330-5p/MAPK signaling pathway. hsa_circ_0071803 hsa_circ_SEMA5A circ_0071803 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Collectively, our findings elucidate that circ_0071803 promotes CRC progression by regulating the miR-330-5p/MAPK1 pathway, providing potential therapeutic targets for designing effective targeted treatments." 2 Silencing circCAMSAP1 suppresses malignant behavior of endometrial cancer by targeting microRNA-370-3p/MAPK1. - hsa_circ_CAMSAP1 circCAMSAP1 DOID:1380 endometrial cancer endometrial cancer RT-qPCR up-regulated "All in all, the results of this study convey silencing circCAMSAP1 refrains the malignant behavior of EC by controlling miR-370-3p /MAPK1 axis." 1 Tumor suppressor circPDE4D inhibits the progression of colorectal cancer and regulates oxaliplatin chemoresistance. hsa_circ_0072568 hsa_circ_PDE4D circPDE4D DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "LV003-CircPDE4D reduced hsa-miR-569 expression while increasing SPI1 expression in HCT116/L. CircPDE4D could inhibit tumorigenesis and progression of both CRC and oxaliplatin-resistant CRC, providing insight for the development of therapeutic strategies." 1 "circGRAMD1B contributes to migration, invasion and epithelial-mesenchymal transition of lung adenocarcinoma cells via modulating the expression of SOX4." - hsa_circ_GRAMD1B circGRAMD1B DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "In conclusion, circGRAMD1B is discovered to modulate miR-4428/SOX4/MEX3A axis to further activate PI3K/AKT pathway, finally boosting migration, invasion, and EMT of LUAD cells." 1 CircRNA-104718 promotes glioma malignancy through regulation of miR-218-5p/HMGB1 signalling pathway. hsa_circ_0085803 hsa_circ_TSNARE1 circRNA-104718 DOID:0060108 brain glioma glioma RT-qPCR up-regulated CircRNA-104718 modulates glioma cell proliferation through the miR-218-5p/HMGB1 signalling axis. CircRNA-104718 provides a possible mechanism for understanding the pathogenesis of glioma. 1 Regulation of CD8(+) T cells infiltration and immunotherapy by circMGA/HNRNPL complex in bladder cancer. hsa_circ_0000591 hsa_circ_MGA circMGA DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "Taken together, the results demonstrate that circMGA/HNRNPL complex may be targetable for cancer immunotherapy and the study advances our understanding of the physiological roles of circRNAs in antitumor immunity." 1 Circ_0012535 Contributes to Lipopolysaccharide-Induced Fetal Lung Fibroblast Apoptosis and Inflammation to Regulate Infantile Pneumonia Development by Modulating the Mir-338-3p/Il6r Signaling. hsa_circ_0012535 hsa_circ_ZCCHC11 circ_0012535 DOID:10533 viral pneumonia infantile pneumonia RT-qPCR up-regulated "Circ_0012535 supported LPS-induced WI38 cell apoptosis and inflammation to promote the progression of infantile pneumonia, and circ_0012535 functioned partly by targeting the miR-338-3p/IL6R signaling." 1 Circular RNA circDLG1 (has_circ_0068706) functions as an oncogene in nonsmall cell lung cancer through regulating AKT/mTOR signaling and direct binding to miR-144. hsa_circ_0068706 hsa_circ_DLG1 - DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "In conclusion, we demonstrate that circDLG1 promotes the pathogenesis and progression of NSCLC by regulating the miR-144/AKT/mTOR signaling axis, providing potential diagnostic and therapeutic targets for designing innovative treatment strategies." 2 CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis. hsa_circ_0135889 hsa_circ_AGO2 circAGO2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "CircAGO2 overexpression decoyed miR-1-3p to increase RBBP4 expression, which inhibited HSPB8 transcription via histone deacetylation in HSPB8 promoter region, promoting proliferation and invasion of CRC cells." 1 Hsa-circ-0000098 promotes the progression of hepatocellular carcinoma by regulation of miR-136-5p/MMP2 axis. hsa_circ_0000098 hsa_circ_SLC30A7 circ-0000098 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated we demonstrated that the mechanism of action of hsa_circ_0000098 in HCC might be due to the regulation of miR-136-5p/MMP2 axis. 4 Circ-FNDC3B Functions as an Oncogenic Factor in Esophageal Squamous Cell Carcinoma via Upregulating MYO5A by Absorbing miR-136-5p and miR-370-3p. hsa_circ_0001361 hsa_circ_FNDC3B circ-FNDC3B DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated These findings demonstrated that circ-FNDC3B contributed to malignant progression of ESCC cells via miR-136-5p/MYO5A or miR-370-3p/MYO5A axis. 4 Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux. hsa_circ_0006421 hsa_circ_PTK2 circPTK2 DOID:552 pneumonia pneumonia RT-qPCR up-regulated "Taken together, circPTK2/miR-766/eIF5A axis ameliorates septic ALI, developing a novel therapeutic target for the disease." 1 CircCCNB1 Knockdown Blocks the Progression of Cervical Cancer by Acting as Competing Endogenous RNA in the miR-370-3p/SOX4 Pathway. - hsa_circ_CCNB1 circCCNB1 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated CircCCNB1 knockdown blocks cervical cancer development by targeting the miR-370-3p/SOX4 pathway. 2 circ_0006089 Facilitates Gastric Cancer Progression via Decoying miR- 515-5p and Up-regulating CXCL6. hsa_circ_0006089 hsa_circ_ASAP2 circ_0006089 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Circ_0006089 facilitates the malignant biological behaviors of GC cells via the miR-515- 5p/CXCL6 axis. 4 "Circ-C16orf62 Regulates Oxidized low-density Lipoprotein-induced Apoptosis, Inflammation, Oxidative Stress and Cholesterol Accumulation of Macrophages via Mediating RAB22A Expression by Targeting miR-377." hsa_circ_0003645 hsa_circ_C16orf62 circ-C16orf62 DOID:1936 atherosclerosis Atherosclerosis RT-qPCR up-regulated "In conclusion, circ-C16orf62 played a crucial role in the regulation of apoptosis, inflammation, oxidative stress and cholesterol accumulation in ox-LDL-treated human macrophages via mediating the miR-377/RAB22A axis, hinting that circ-C16orf62 might be involved in AS progression." 3 The hsa_circ_0000276-ceRNA regulatory network and immune infiltration in cervical cancer. hsa_circ_0000276 hsa_circ_TRIM22 circ_0000276 DOID:4362 cervical cancer cervical cancer "RT-qPCR, microarray" up-regulated Our findings show that hsa_circ_0000276 exerts cancer-promoting effects in cervical cancer and is an underlying biomarker for cervical squamous cell carcinoma. 1 CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway. - hsa_circ_DNAJC11 circDNAJC11 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "The circDNAJC11/TAF15/MAPK6 axis played a crucial role in the progression and development of BC, suggesting that circDNAJC11 might be a novel biomarker and therapeutical target for BC." 1 EIF4A3 induced circABCA5 promotes the gastric cancer progression by SPI1 mediated IL6/JAK2/STAT3 signaling. hsa_circ_0107595 hsa_circ_ABCA5 circABCA5 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Our study reveals that circABCA5 plays a vital role in the diagnosis and prognosis of gastric cancer and may even be developed as a molecular target for the treatment of gastric cancer. 1 A novel circular RNA circRBMS3 regulates proliferation and metastasis of osteosarcoma by targeting miR-424-eIF4B/YRDC axis. hsa_circ_0064644 hsa_circ_RBMS3 circRBMS3 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Our results reveal an important role for a novel circRBMS3 in the growth and metastasis of malignant tumor cells and offer a fresh perspective on circRNAs in OS progression. 1 Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h. - hsa_circ_AAGAB circAAGAB DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "These findings suggest that the oxygen-responsive circAAGAB acts as a tumor suppressor in breast cancer, and may contribute to the development of a more specific therapeutic regimen for breast cancer." 1 The oncogenic circular RNA circ_63706 is a potential therapeutic target in sonic hedgehog-subtype childhood medulloblastomas. - hsa_circ_PCNT circ_63706 DOID:0050902 medulloblastoma medulloblastoma RT-qPCR up-regulated Our study implicates a novel oncogenic circular RNA in the SHH medulloblastoma subgroup and establishes its molecular function and potential as a future therapeutic target. 1 Circ_0000595 knockdown alleviates CoCl2-mediated effects in VSMCs by regulating the miR-582-3p/ADAM10 axis. hsa_circ_0000595 hsa_circ_CASC4 circ_0000595 DOID:14004 thoracic aortic aneurysm thoracic aortic aneurysm RT-qPCR up-regulated "Our data verified that circ_0000595 silencing might attenuate CoCl2-mediated impacts in VSMCs by regulating the miR-582-3p/ADAM10 axis, providing new potential roads for treating TAA." 1 Circular RNA circ_0000741/miR-379-5p/TRIM14 signaling axis promotes HDAC inhibitor (SAHA) tolerance in glioblastoma. hsa_circ_0000741 hsa_circ_POLR2A circ_0000741 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "Circ_0000741 might accelerate SAHA tolerance by regulating the miR-379-5p/TRIM14 axis, which provided a promising therapeutic target for GBM treatment." 2 Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer. hsa_circ_0078607 hsa_circ_SLC22A3 circ_0078607 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated "Circ_0078607 attenuates DDP resistance via miR-196b-5p/GAS7 axis, which highlights the therapeutic potential of circ_0078607 to counter DDP resistance in OC." 4 METTL3-mediated m6A modification of has_circ_0007905 promotes age-related cataract progression through miR-6749-3p/EIF4EBP1. hsa_circ_0007905 hsa_circ_STX6 circ_0007905 DOID:0070353 cataract cataract "RT-qPCR, microarray" up-regulated "We reveal for the first time that the commitment of ARC progression is guided by METTL3/has_circ_0007905/miR-6749-3p/EIF4EBP1 axis, and the results provide new insights into ARC pathology." 1 Identification of hsa_circRNA_100632 as a novel molecular biomarker for fulminant type 1 diabetes. - - "circRNA_100632, hsa_circRNA_100632" DOID:9744 type 1 diabetes mellitus type 1 diabetes RT-qPCR up-regulated "CircRNAs were aberrantly expressed in PBMCs of patients with FT1D, and hsa_circRNA_100632 may be a diagnostic marker of FT1D." 1 Hsa_circ_0084912 Drives the Progression of Cervical Cancer Via Regulating miR-429/SOX2 Pathway. hsa_circ_0084912 hsa_circ_KIAA1429 circ_0084912 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "By raising SOX2 expression by targeting miR-429, hsa_circ_0084912 accelerated the development of CC, offering fresh proof that it is a viable target for CC treatment." 2 "circPTK2 promotes proliferation, migration and invasion of trophoblast cells through the miR-619/WNT7B pathway in preeclampsia." hsa_circ_0005273 hsa_circ_PTK2 circPTK2 DOID:10591 pre-eclampsia preeclampsia RT-qPCR down-regulated "To conclude, this study identified the functions and mechanisms of the circPTK2/miR-619/WNT7B axis in PE progression." 1 Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-beta1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling. mmu_circ_0000468 mmu_circ_Ntrk2 circ-Ntrk2 DOID:10763 hypertension hypertension "RT-qPCR, RNA-seq" up-regulated "We identified a new circRNA (circ-Ntrk2) and explored its function and mechanism in PAH, thereby establishing potential targets for the diagnosis and treatment of PAH." 1 Diagnostic and prognostic value of serum CircERBB2 level in NSCLC and its correlation with clinicopathological features in NSCLC patients. hsa_circ_0007766 hsa_circ_ERBB2 circERBB2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Serum CircERBB2 is highly expressed in NSCLC patients, and closely related to disease progression, so it has good prognostic value." 1 Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression of esophageal squamous cell carcinoma by upregulating transcription factor 12. hsa_circ_0002938 hsa_circ_CRIM1 circCRIM1 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "Taken together, circCRIM1 facilitates the progression of ESCC by sponging miR-342-3p to regulate TCF12 and promote EMT, and the circCRIM1/miR-342-3p/TCF12 axis may be regarded as a potential predictive biomarker and therapeutic target for treating ESCC." 1 "Circ_0008450 regulates keloid-derived fibroblast proliferation, migration, invasion and apoptosis with increased IGFBP5 through sponging miR-1224-5p." hsa_circ_0008450 hsa_circ_CMTM3 circ_0008450 DOID:10881 "hand, foot and mouth disease" keloid-derived fibroblast RT-qPCR up-regulated "Circ_0008450 promoted KD-derived fibroblast proliferation, migration, and invasion and repressed apoptosis via sponging miR-1224-5p and elevating IGFBP5." 1 Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis. hsa_circ_0043216 hsa_circ_ACACA circACACA DOID:9256 colorectal cancer colorectal tumorigenesis RT-qPCR up-regulated "circACACA promoted CRC progression via regulating the miR-193a/b-3p/HDAC3/p53 axis to activate the MVA pathway, providing evidence for circACACA as a promising therapeutic target for CRC." 1 "Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC." hsa_circ_0007429 hsa_circ_RREB1 circ_0007429 DOID:684 hepatocellular carcinoma HCC RT-qPCR up-regulated "Circ_0007429 promotes HCC progression by promoting cell proliferation, migration, invasion, and aerobic glycolysis and by inhibiting cell apoptosis through the miR/TRIM71/Ago2 axis." 1 Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation. hsa_circ_0001361 hsa_circ_FNDC3B circ_0001361 DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated "Our results suggested that hsa_circ_0001361 upregulated TRIM2 by absorbing miR-490-5p, thereby promoting cell malignant behaviors and glycolytic metabolism in NB." 1 Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway. hsa_circ_0005615 hsa_circ_NFATC3 circ_0005615 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circ_0005615 modulated CRC malignant progression by controlling FOSL2 expression through sponging miR-873-5p. 3 CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect. hsa_circ_0000817 hsa_circ_FOXK2 circFOXK2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "circFOXK2 upregulated the expression of protein FOXK2-142aa to promote LDHA phosphorylation and led to mitochondrial fission by regulating the miR-484/Fis1 pathway, ultimately activating the Warburg effect in HCC." 1 CircSTK3 drives the metastasis of colorectal cancer by regulating epithelial-mesenchymal transition. hsa_circ_0004592 hsa_circ_STK3 circSTK3 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated These findings reveal the functional and prognostic roles of circSTK3 and expose circRNAs as key players in metastasis. 1 CircRNA_0075723 protects against pneumonia-induced sepsis through inhibiting macrophage pyroptosis by sponging miR-155-5p and regulating SHIP1 expression. hsa_circ_0075723 - circ_0075723 DOID:552 pneumonia pneumonia "RT-qPCR, RNA-seq" down-regulated circRNAs could be used as possible potential diagnostic and therapeutic targets for pneumonia-induced sepsis. 1 Overexpression of circRNAs LRP6 in gestational diabetes mellitus predicts foetal malformation and intrauterine death. - hsa_circ_LRP6 circRNA LRP6 DOID:11714 gestational diabetes gestational diabetes mellitus RT-qPCR up-regulated "Therefore, increased expression levels of LRP6 in GDM predicts foetal malformation and intrauterine death." 1 Circ_0058063 Contributed to Oral Squamous Cell Carcinoma Development by Sponging miR-145 and Regulating PI3K/AKT Pathway. hsa_circ_0058063 hsa_circ_ATIC circ_0058063 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Our results revealed that circ_0058063 functions as an oncogene via regulation of the PI3K/AKT pathway by targeting miR-145-5p in OSCC, suggesting its potential for OSCC diagnosis and treatment." 1 Circular RNA LPAR3 targets JPT1 via microRNA-513b-5p to facilitate glycolytic activation but repress prostate cancer radiosensitivity. - hsa_circ_LPAR3 circLPAR3 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "In summary, the knockdown of circLPAR3 reduces glycolysis, but promotes PCa radiosensitivity via the miR-513b-5p/JPT1 axis, discovering a novel mechanism in PCa progression." 1 Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma. hsa_circ_0000240 hsa_circ_CCAR1 circCCAR1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated The circCCAR1/miR-127-5p/WTAP feedback loop enhances the growth and metastasis of HCC. 1 circMMD reduction following tumor treating fields inhibits glioblastoma progression through FUBP1/FIR/DVL1 and miR-15b-5p/FZD6 signaling. hsa_circ_0002015 hsa_circ_MMD circMMD DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated Our study revealed a novel mechanism of TTF that TTF-mediated reduction of circMMD could inhibit Wnt/beta-catenin pathway to suppress GBM proliferation. 1 Plasma exosome-derived circGAPVD1 as a potential diagnostic marker for colorectal cancer. hsa_circ_0003270 hsa_circ_GAPVD1 circGAPVD1 DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated Our results revealed the diagnostic efficiency of circGAPVD1 in plasma exosomes. The highly expressed circGAPVD1 is expected to be a novel diagnostic marker for CRC. 1 Circular RNA SLTM as a miR-421-competing endogenous RNA to mediate HMGB2 expression stimulates apoptosis and inflammation in arthritic chondrocytes. hsa_circ_0000605 hsa_circ_SLTM circSLTM DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Taken together, our findings demonstrate the fundamental role of circSLTM in OA progression and provide a potential molecular target for OA therapy." 1 "NR1H4-mediated circRHOBTB3 modulates the proliferation, metastasis, and Warburg effects of cervical cancer through interacting with IGF2BP3." hsa_circ_0007444 hsa_circ_RHOBTB3 circRHOBTB3 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In conclusion, this novel NR1H4/circRHOBTB3/IGF2BP3 axis may provide new insights into CC pathogenesis." 1 "Circ_0000479 promotes proliferation, invasion, migration and inflammation and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes via miR-766/FKBP5 axis." hsa_circ_0000479 hsa_circ_EPSTI1 circ_0000479 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "In summary, circ_0000479 binds to miR-766 to promote RA progression via FKBP5." 1 CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p. hsa_circ_0001554 hsa_circ_RANBP17 circRANBP17 DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated "circRANBP17 modulated KDM1A to promote cell proliferation, migration, invasion and restrain cell apoptosis in NB by sponging miR-27b-3p, and the new regulatory network may provide a theoretical basis for the further study of NB." 1 Hsa_circ_0003528 promotes cell malignant transformation and immune escape via increasing oncogene PDL1 through sponging miR-511-3p in non-small cell lung cancer. hsa_circ_0003528 hsa_circ_SEC24A circ_0003528 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0003528 facilitated NSCLC cell malignant transformation and immune escape through regulation of the miR-511-3p/PDL1 axis, highlighting the oncogenic role of circ_0003528 in NSCLC." 1 Circ_0002715 promotes the development of osteoarthritis through regulating LXN by sponging miR-127-5p. hsa_circ_0002715 - circ_0002715 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "Circ_0002715 might be a new therapeutic target for OA, which regulated miR-127-5p/LXN axis to promote IL-1beta-induced chondrocyte injury." 1 Circular RNA circHMCU promotes breast tumorigenesis through miR-4458/PGK1 regulatory cascade. hsa_circ_0000247 hsa_circ_HMCU circHMCU DOID:1612 breast cancer breast cancer RT-qPCR up-regulated CircHMCU acted as an oncogenic factor by regulating the miR-4458/PGK1 axis in BC. 2 Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells. hsa_circ_0013880 hsa_circ_TXNIP circ_0013880 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "Overall, our findings will enrich the understanding of the hsa_circ_0013880/USP32/Rap1b axis in AML development, which may contribute to the development of novel therapeutic strategies for AML." 1 A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer. - hsa_circ_RERE circRERE DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "These results uncover modulatory axis constituting of EP300/circRERE/miR-6837-3p/MAVS and its essential roles in antitumor immunity, and demonstrate that circRERE-AAV might represent a new therapeutic avenue to prime immune responses and boost the effects of immunotherapy in clinic." 1 Regulation of Cervical Cancer Development by a Novel Circ_0000212/miR-1236-3p/GREM1 ceRNA Crosstalk. hsa_circ_0000212 hsa_circ_SFMBT2 circ_0000212 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Our findings identify a novel ceRNA regulatory network, circ_0000212/miR-1236-3p/GREM1 axis, in cervical carcinogenesis, and provide potential targets that can be explored for therapeutic interventions." 3 Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer Progression through miR-1184/RAP2B Axis. hsa_circ_0008035 hsa_circ_EXT1 circ_0008035 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Circ_0008035-mediated BC progression via regulating the miR-1184/RAP2B axis, providing a potential target for BC treatment." 2 FOXC2-induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression. hsa_circ_0001917 hsa_circ_CASK circCASK DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "In conclusion, circCASK induced by FOXC2 accelerated CRC progression through the miR-1271-5p/SIX1 axis, thus providing an interesting insight into CRC tumorigenesis." 1 circNEIL3 inhibits tumor metastasis through recruiting the E3 ubiquitin ligase Nedd4L to degrade YBX1. hsa_circ_0001460 hsa_circ_NEIL3 circNEIL3 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Collectively, our findings indicate the YBX1-dependent antimetastatic function of circNEIL3 and highlight the potential of circNEIL3 as a biomarker and therapeutic option in cancer treatment." 1 A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis. hsa_circ_0052582 hsa_circ_RRM2 circRRM2 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "The positive feedback loop of circRRM2/IGF2BP1/MYC enforces the circRRM2 expression, which might offer a potential target for BC treatment." 1 Hypoxia-treated umbilical mesenchymal stem cell alleviates spinal cord ischemia-reperfusion injury in SCI by circular RNA circOXNAD1/ miR-29a-3p/ FOXO3a axis. - hsa_circ_OXNAD1 circOXNAD1 DOID:319 spinal cord disease spinal cord ischemia-reperfusion injury RT-qPCR up-regulated The exosomal circOXNAD1 alleviated SCI through sponging miR-29a-3p and consequently elevated the FOXO3a expression. 1 hsa_circ_0000047 targeting miR-6720-5p/CYB5R2 axis alleviates inflammation and angiogenesis in diabetic retinopathy. hsa_circ_0000047 - - DOID:8947 diabetic retinopathy diabetic retinopathy RT-qPCR down-regulated "Our study revealed that hsa_circ_0000047 alleviated inflammation and angiogenesis in HG-induced hRMECs by targeting the miR-6720-5p/CYB5R2 axis, which may be a novel biomarker for DR therapy." 1 [Expression and clinical significance of circRNA cSMARCA5 in patients with acute myocardial infarction]. hsa_circ_0001445 hsa_circ_SMARCA5 cSMARCA5 DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR down-regulated "The expression of cSMARCA5 is significantly decreased in peripheral blood of AMI patients compared with control group, and its expression level is negatively correlated with the severity of myocardial infarction. cSMARCA5 is expected to be a potential biomarker of AMI." 1 CircXPO1 Promotes Glioblastoma Malignancy by Sponging miR-7-5p. hsa_circ_0001017 hsa_circ_XPO1 circXPO1 DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated "In conclusion, our studies suggest that the circXPO1/miR-7-5p/RAF1 axis promotes brain tumor formation and may be a potential therapeutic target for GBM treatment." 1 Competing Endogenous RNA Regulatory Networks of hsa_circ_0126672 in Pathophysiology of Coronary Heart Disease. hsa_circ_0126672 hsa_circ_KIAA1211 circ_0126672 DOID:3393 coronary artery disease coronary heart disease "RT-qPCR, microarray" up-regulated "hsa_circ_0126672 and target miRNAs, notably miR-145-5p, could be good candidates for the diagnosis and therapeutic approaches to CHD." 1 Circular RNA CircCDKN2B-AS_006 Promotes the Tumor-like Growth and Metastasis of Rheumatoid Arthritis Synovial Fibroblasts by Targeting the miR-1258/RUNX1 Axis. - hsa_circ_circCDKN2B-AS circCDKN2B-AS_006 DOID:7148 rheumatoid arthritis rheumatoid arthritis "RT-qPCR, RNA-seq" up-regulated "CircCDKN2B-AS_006 promoted the proliferation, migration, and invasion of RASFs by modulating the miR-1258/RUNX1 axis." 1 Diagnostic significance of hsa_circ_0000146 and hsa_circ_0000072 biomarkers for Diabetic Kidney Disease in patients with type 2 diabetes mellitus. hsa_circ_0000146 hsa_circ_FCGR2A circ_0000146 DOID:557 kidney disease diabetic kidney disease RT-qPCR down-regulated The functional prediction results showed the involvement of hsa_circ_0000146 and 0000072 in various pathways that regulate DKD. 1 Diagnostic significance of hsa_circ_0000146 and hsa_circ_0000072 biomarkers for Diabetic Kidney Disease in patients with type 2 diabetes mellitus. hsa_circ_0000072 hsa_circ_OMA1 circ_0000072 DOID:557 kidney disease diabetic kidney disease RT-qPCR down-regulated The functional prediction results showed the involvement of hsa_circ_0000146 and 0000072 in various pathways that regulate DKD. 1 Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma. hsa_circ_0000251 hsa_circ_IDE circIDE DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Collectively, our findings established circIDE/miR-19b-3p/RBMS1 axis as a regulator of ferroptosis, which could be a promising therapeutic target and prognostic factor." 1 CircZFR promotes pancreatic cancer progression through a novel circRNA-miRNA-mRNA pathway and stabilizing epithelial-mesenchymal transition protein. hsa_circ_0072088 hsa_circ_ZFR circZFR DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "Collectively, our findings implicate circZFR as a positive regulator of PC progression through the miR-375/GREM2/JNK axis." 2 circACTR2 attenuates gemcitabine chemoresiatance in pancreatic cancer through PTEN mediated PI3K/AKT signaling pathway. hsa_circ_0008529 hsa_circ_ACTR2 "circACTR2, circRNA_102747" DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR down-regulated circACTR2 reversed the chemoresistance of PC cells to GEM through inhibiting PI3K/AKT signaling pathway by sponging miR-221-3p and upregulating PTEN expression. 1 hsa_circ_0017842 acts as a competing endogenous RNA to enhance the malignancy of gastric cancer. hsa_circ_0017842 hsa_circ_FAM188A circ_0017842 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Overall, this study confirmed that hsa_circ_0017842 acted as a ceRNA to promote the malignancy of GC cells through regulating the miR-1294/SPARC axis." 1 Exosomal Circ_FMN2 Derived from the Serum of Colorectal Cancer Patients Promotes Cancer Progression by miR-338-3p/MSI1 Axis. hsa_circ_0005100 hsa_circ_FMN2 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Exosomal circ_FMN2 accelerated CRC progression through miR-338-3p/MSI1 axis, revealing that exosomal circ_FMN2 might be a target for CRC treatment." 4 RNA helicase DDX5-induced circPHF14 promotes gastric cancer cell progression. hsa_circ_0079440 hsa_circ_PHF14 circPHF14 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "These findings suggest that in addition to the messenger RNA and microRNA patterns, DDX5 also effects a circRNA pattern, as demonstrated by circPHF14. DDX5-induced circRNAs have been found to be of crucial importance for the growth of DDX5-positive gastric cancer cells, providing a new therapeutic target." 2 Identification of hsa_circ_0001445 of a novel circRNA-miRNA-mRNA regulatory network as potential biomarker for coronary heart disease. hsa_circ_0001445 hsa_circ_SMARCA5 circ_0001445 DOID:3393 coronary artery disease coronary heart disease RT-qPCR down-regulated The hsa_circ_0001445 level in peripheral blood leukocytes may serve as a biomarker for CHD diagnosis. Our work on circRNA-miRNA-mRNA networks suggests a potential role for hsa_circ_0001445 in CHD development. 2 Circ_0073228 serves as a competitive endogenous ribonucleic acid to facilitate proliferation and inhibit apoptosis of hepatocellular carcinoma cells by the miR-139-5p/deoxyribonuclease II axis. hsa_circ_0073228 hsa_circ_RPS23 circ_0073228 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circ_0073228 serves as an oncogene to facilitate growth and inhibit apoptosis of HCC cells by regulating the miR-139-5p/DNASE2 axis. 1 Inhibition of sepsis-induced acute kidney injury via the circITCH-miR-579-3p-ZEB2 axis. - hsa_circ_ITCH circITCH DOID:3021 acute kidney failure acute kidney injury RT-qPCR down-regulated "circITCH alleviates LPS-induced HK-2 cell injury by regulating miR-579-3p/ZEB2 signal axis, which provides a theoretical basis for AKI therapy." 1 CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway. hsa_circ_0000512 hsa_circ_RPPH1 circRPPH1 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Overall, circRPPH1 could promote BCa progression through sponging miR_296_5p to upregulate the expression of STAT3 and interacting with FUS to promote p_STAT3 nuclear transport." 2 Ox-LDL-Induced Vascular Smooth Muscle Cell Dysfunction Partly Depends on the Circ_0044073/miR-377-3p/AURKA Axis in Atherosclerosis. hsa_circ_0044073 hsa_circ_GRN circ_0044073 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Circ_0044073 promoted AS progression by elevating AURKA expression by functioning as a miR-377-3p sponge. 3 "CircUSP39/miR-362-3p/TRAF3 Axis Mediates Hypoxia/Reoxygenation-Induced Cardiomyocyte Oxidative Stress, Inflammation, and Apoptosis." hsa_circ_0055440 hsa_circ_USP39 circUSP39 DOID:9408 acute myocardial infarction acute myocardial Infarction "RT-qPCR, microarray" up-regulated "CircUSP39 could facilitate H/R-induced cardiomyocyte oxidative stress, inflammation, and apoptosis by the miR-362-3p/TRAF3 axis, elucidating that it might be a therapeutic target for AMI." 1 Hsa_circRNA_001859 regulates pancreatic cancer progression and epithelial-mesenchymal transition through the miR-21-5p/SLC38A2 pathway. hsa_circ_0001339 hsa_circ_ISY1 circRNA_001859 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" down-regulated "This study suggests that circ_001859 may inhibit the proliferation, invasion and EMT of pancreatic cancer through the miR-21-5p/SLC38A2 pathway." 1 Hsa_circ_0070661 inhibits cancer progression through miR-556-5p/TEK axis in lung adenocarcinoma. hsa_circ_0070661 hsa_circ_CCDC109B circ_0070661 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated "Hsa_circ_0070661 sponges miR-556-5p to inhibit LUAD development via regulating TEK, providing a promising molecular target for LUAD clinical therapy." 1 Circ_0003028 enhances the proliferation and glycolytic capacity and suppresses apoptosis in non-small cell lung cancer cells via the miR-1305/miR-1322-SLC5A1 axis. hsa_circ_0003028 hsa_circ_FUT8 circ_0003028 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0003028 could accelerate the malignant behaviors and glycolytic capacity of NSCLC cells via a mechanism that may be related to miR-1305 or the miR-1322/SLC5A1 axis. 3 Positive Feedback Regulation of Circular RNA Hsa_circ_0000566 and HIF-1alpha promotes Osteosarcoma Progression and Glycolysis Metabolism. hsa_circ_0000566 hsa_circ_VRK1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Taken together, these data indicate the significance of Hsa_circ_0000566 in the Warburg effect and suggest that Hsa_circ_0000566 could be a potential therapeutic target to combat OS progression." 1 CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS. - hsa_circ_PVT1 circPVT1 DOID:1612 breast cancer breast cancer "RT-qPCR, RNA-seq" up-regulated "Thus, circPVT1 may serve as a diagnostic biomarker and therapeutic target for ERalpha-positive breast cancer in the clinic." 4 Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p-HMGB1 axis. hsa_circ_0046701 hsa_circ_YES1 circ-YES1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Taken together, our results show that circ-YES1 promotes tumor development through the miR-142-3p-HMGB1 axis and support the development of circ-YES1 probability as a new therapeutic NSCLC target." 1 Cardioprotective effects of circ_0002612 in myocardial ischemia/reperfusion injury correlate with disruption of miR-30a-5p-dependent Ppargc1a inhibition. hsa_circ_0002612 hsa_circ_SAMD4A circ_0002612 DOID:1287 cardiovascular system disease myocardial ischemia-reperfusion injury "RT-qPCR, microarray" down-regulated "Overall, this study demonstrates the cardioprotective role of circ_0002612 against MI/RI, which may be a viable target for MI/RI." 1 "CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy." - hsa_circ_EPS15 circEPS15 DOID:14330 Parkinson disease Parkinson disease RT-qPCR down-regulated circEPS15 rescued DA neuronal degeneration through the MIR24-3p-PINK1 axis-mediated improvement of mitochondrial function. 1 Circular RNA circ-TNRC6B inhibits the proliferation and invasion of esophageal squamous cell carcinoma cells by regulating the miR-452-5p/DAG1 axis. hsa_circ_0000277 hsa_circ_TNRC6B circ-TNRC6B DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR down-regulated These findings demonstrated that circ-TNRC6B exerts a tumor-suppressing effect in ESCC through the miR-452-5p/DAG1 axis. 3 CircABCA13 acts as a miR-4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1. hsa_circ_0001707 hsa_circ_ABCA13 circABCA13 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "Collectively, our study uncovered the oncogenic role of circABCA13 and its mechanism in ESCC, suggesting that circABCA13 could be a potential therapeutic target and a predictive biomarker for ESCC patients." 1 Circular RNA 0000311 Aggravates the Aggressiveness of Oral Squamous Cell Carcinoma via miR-876-5p/EZH2 Axis. hsa_circ_0000311 hsa_circ_SDHAF2 circ_0000311 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "Taken together, circ_0000311 aggravated the OSCC progression via regulating miR-876-5p/EZH2 axis." 1 Hsa_circ_0003928 regulates the progression of diabetic nephropathy through miR-136-5p/PAQR3 axis. hsa_circ_0003928 hsa_circ_TAOK1 circ_0003928 DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "Circ_0003928 acted as a sponge of miR-136-5p to up-regulating PAQR3 expression, and then regulate the proliferation, oxidative stress, fibrosis and apoptosis in HG-induced HK-2 cells." 3 Analysis and verification of the circRNA regulatory network RNO_CIRCpedia_ 4214/RNO-miR-667-5p/Msr1 axis as a potential ceRNA promoting macrophage M2-like polarization in spinal cord injury. - - RNO_CIRCpedia_4214 DOID:319 spinal cord disease spinal cord injury "RT-qPCR, microarray" up-regulated The RNO_CIRCpedia_4214/RNO-miR-667-5p/Msr1 axis may be a potential ceRNA that promotes macrophage M2-like polarization in SCI. 1 Nanoparticles Mediated circROBO1 Silencing to Inhibit Hepatocellular Carcinoma Progression by Modulating miR-130a-5p/CCNT2 Axis. - hsa_circ_ROBO1 circROBO1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Our findings firstly demonstrate that circROBO1 overexpression promotes HCC progression by regulating miR-130a-5p/CCNT2 axis, which may serve as an effective nanotherapeutic target for HCC treatment." 1 Isoliquiritigenin regulates the circ_0002860/miR-431-5p/RAB9A axis to function as a tumor inhibitor in melanoma. hsa_circ_0002860 hsa_circ_CFLAR circ_0002860 DOID:1909 melanoma melanoma RT-qPCR down-regulated The current data indicates that ISL suppressed cell malignant progression of melanoma via targeting the circ_0002860/miR-431-5p/RAB9A pathway. 1 Hsa_circ_0044235 and hsa_circ_0001947 as novel biomarkers in plasma of patients with new-onset systemic lupus erythematosus. hsa_circ_0044235 hsa_circ_CDC27 circ_0044235 DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR down-regulated "Thus, the present study demonstrated a promise for the combination of plasma hsa_circ_0044235 and hsa_circ_0001947 expression as potential diagnostic and prognostic biomarkers in patients with new-onset SLE." 2 Hsa_circ_0044235 and hsa_circ_0001947 as novel biomarkers in plasma of patients with new-onset systemic lupus erythematosus. hsa_circ_0001947 hsa_circ_AFF2 circ_0001947 DOID:9074 systemic lupus erythematosus systemic lupus erythematosus RT-qPCR down-regulated "Thus, the present study demonstrated a promise for the combination of plasma hsa_circ_0044235 and hsa_circ_0001947 expression as potential diagnostic and prognostic biomarkers in patients with new-onset SLE." 1 hsa_circ_0136839 regulates the malignant phenotypes of nasopharyngeal carcinoma via the Wnt/beta-catenin signaling pathway. hsa_circ_0136839 hsa_circ_ERICH1 circ_0136839 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma "RT-qPCR, RNA-seq" down-regulated we demonstrated that aberrant hsa_circ_0136839 expression might affect the malignant phenotypes of NPC cells by activating the wnt/beta-catenin signaling pathway. 1 circSOBP Inhibits Bladder Cancer Proliferation and Metastasis by Regulating the miR-200a-3p/PTEN Axis and Participating in the Immune Response. hsa_circ_0001633 hsa_circ_SOBP circSOBP DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "Overall, circSOBP inhibits BCa tumorigenesis and metastasis by a novel miR-200a-3p/PTEN axis, which makes it an excellent biomarker and therapeutic target for treating BCa." 1 Profiling of circRNA expressions in radiation-treated head and neck cancer cells and the potential role of circPVT1. hsa_circ_0001821 hsa_circ_PVT1 circPVT1 DOID:11934 head and neck cancer head and neck cancer "RT-qPCR, RNA-seq" up-regulated "These findings suggest that certain circRNAs, especially circPVT1, may be potential biomarkers to monitor radiotherapy effects in patients with HNCs." 1 Highly expressed circ_0000285 from serum and cervical exfoliated cells as a novel biomarker for the diagnosis of early stage-cervical cancer. hsa_circ_0000285 hsa_circ_HIPK3 circ_0000285 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In summary, highly expressed circ_0000285 from serum and cervical exfoliated cells might be a promising diagnostic biomarker for ESCC." 4 Circ_0000231 promotes paclitaxel resistance in ovarian cancer by regulating miR-140/RAP1B. hsa_circ_0000231 hsa_circ_ARHGAP12 circ_0000231 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "we demonstrated that circ_0000231 acted as a sponge for miR-140, and RAP1B was the target gene of miR-140." 1 Circ8199 encodes a protein that inhibits the activity of OGT by JAK2-STAT3 pathway in esophageal squamous cell carcinoma. hsa_circ_0008199 hsa_circ_ATXN10 circ8199 DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma RT-qPCR up-regulated "Our study indicated that circ8199 regulates the JAK2-STAT3 pathway through OGT, providing a candidate mechanism for drug discovery and development." 1 Circular RNA hsa_circ_0005218 promotes the early recurrence of hepatocellular carcinoma by targeting the miR-31-5p/CDK1 pathway. hsa_circ_0005218 hsa_circ_FAM120A - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Taken together, the present study indicates that circ_0005218 absorbed miR-31-5p as a sponge to weaken its suppression on CDK1 expression, and thus boost HCC cell invasion and migration, which would act as a potential biomarker to predict the HCC early recurrence and as a new therapeutic target for treatment of HCC." 1 circRNA_17725 Promotes Macrophage Polarization towards M2 by Targeting FAM46C to Alleviate Arthritis. - - circRNA_17725 DOID:848 arthritis arthritis "RT-qPCR, RNA-seq" down-regulated "This study has suggested that circRNA_17725 regulated macrophage proliferation, apoptosis, inflammation, and polarization by sponging miR-4668-5p and upregulating FAM46C in RA." 1 CircFAM114A2 inhibits the progression of hepatocellular carcinoma via miR-630/HHIP axis. - hsa_circ_FAM114A2 circFAM114A2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "CircFAM114A2 exerts a tumor suppressor role in HCC through miR-630/HHIP axis, and may be served as a potential diagnostic and therapeutic biomarker for HCC patients." 1 Circular forms of dedicator of cytokinesis 1 promotes breast cancer progression by derepressing never in mitosis related kinase 2 via sponging miR-128-3p. hsa_circ_0007142 hsa_circ_DOCK1 circDOCK1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated We therefore conclude that circDOCK1 promotes breast cancer progression by targeting miR-128-3p-mediated downregulation of NEK2 and that the circDOCK1/hsa-miR-128-3p/NEK2 axis may be a novel therapeutic target for breast cancer treatment. 1 Downregulation of circ-STK39 suppresses pancreatic cancer progression by sponging mir-140-3p and regulating TRAM2-mediated epithelial-mesenchymal transition. hsa_circ_0001079 hsa_circ_STK39 circ-STK39 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "In this regard, we showed that circ-STK39 downregulation led to decreased migration, proliferation and the EMT of PC via the miR-140-3p/TRAM2 axis." 1 CircPTPRA promotes the progression of pancreatic ductal adenocarcinoma via the miR-140-5p/LMNB1 axis. hsa_circ_0006117 hsa_circ_PTPRA circPTPRA DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, microarray" up-regulated This study revealed that circPTPRA plays an important role in the progression of PDAC by sponging miR-140-5p. 1 "Circ_0082476 targets miR-138-5p to promote proliferation, invasion, migration and inflammation in IL-22-treated human keratinocytes by upregulating BRD4." hsa_circ_0082476 - circ_0082476 DOID:8893 psoriasis psoriasis RT-qPCR up-regulated These findings disclosed that circ_0082476 facilitated the IL22-induced epidermis cell injury in psoriasis through the upregulation of BRD4 via binding to miR-138-5p. 1 Hsa_circ_0073453 modulates IL-8 secretion by GC-MSCs to promote gastric cancer progression by sponging miR-146a-5p. hsa_circ_0073453 hsa_circ_RHOBTB3 circ_0073453 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Taken together, our findings suggest that circ_0073453/miR-146a-5p/IL-8 axis is critical for GC-MSCs promoting gastric cancer progression. Hence, hsa_circ_0073453 may be a potential therapeutic target for gastric cancer." 2 Circ_0060967 contributes to colorectal cancer progression by sponging miR-1184 to up-regulate SRC proto-oncogene. hsa_circ_0060967 hsa_circ_RAE1 circ_0060967 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "This study demonstrates a novel circ_0060967/miR-1184/SRC regulatory cascade in affecting CRC cell malignant behaviors, which can have a broad effect on the field of molecularly targeted therapeutics." 1 Exosomal circSPIRE1 mediates glycosylation of E-cadherin to suppress metastasis of renal cell carcinoma. hsa_circ_0000829 hsa_circ_SPIRE1 circSPIRE1 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR down-regulated "In conclusion, circSPIRE1 may be a predictor of metastasis and a potential therapeutic target of metastatic RCC." 1 CircRNA RNA hsa_circ_0008234 Promotes Colon Cancer Progression by Regulating the miR-338-3p/ETS1 Axis and PI3K/AKT/mTOR Signaling. hsa_circ_0008234 hsa_circ_FOXP1 - DOID:219 colon cancer colon cancer RT-qPCR up-regulated "In conclusion, hsa_circ_0008234 increases colon cancer proliferation, infiltration, and migration via the miR-338-3p/ETS1/PI3K/AKT axis; therefore, it could serve as a target and a focus for colon cancer therapy." 1 Silencing circular RNA hsa_circABCC1 inhibits osteosarcoma progression through down-regulating HDAC4 via sponging miR-591. hsa_circ_0000677 hsa_circ_ABCC1 hsa_circABCC1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated Silencing of circABCC1 inhibits osteosarcoma progression by attenuating HDAC4 expression through sponging miR-591. 1 CircSCUBE3 Reduces the Anti-gastric Cancer Activity of Anti-PD-L1. hsa_circ_0076092 hsa_circ_SCUBE3 circSCUBE3 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Our study revealed the importance of the circSCUBE3/miR-744-5p/SLC7A5 axis in GC immune escape and anti-PD-1 resistance. 1 "The circular RNA Rap1b promotes Hoxa5 transcription by recruiting Kat7 and leading to increased Fam3a expression, which inhibits neuronal apoptosis in acute ischemic stroke." mmu_circ_0001992 mmu_circ_Rap1b circRap1b DOID:2316 brain ischemia acute ischemic stroke RT-qPCR down-regulated "Taken together, these findings demonstrate the mechanism by which circRap1b inhibits neuronal apoptosis in acute ischemic stroke." 1 M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy. hsa_circ_0001771 hsa_circ_RBM33 circRBM33 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "Our study suggested that the m6A-mediated circRBM33-FMR1 complex can activate mitochondrial metabolism by stabilizing PDHA1 mRNA, which promotes PCa progression, and can attenuate circRBM33 increased ARSI effectiveness in PCa treatment." 1 Circular RNA hsa_circ_0007444 inhibits ovarian cancer progression through miR-23a-3p/DICER1 axis. hsa_circ_0007444 hsa_circ_RHOBTB3 - DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Therefore, hsa_circ_0007444 can inhibit ovarian cancer progression through the hsa_circ_0007444/miR-23a-3p/DICER1 axis." 2 Exosomal circCOL1A2 from cancer cells accelerates colorectal cancer progression via regulating miR-665/LASP1 signal axis. hsa_circ_0081069 hsa_circ_COL1A2 circCOL1A2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "In conclusion, exosomal circCOL1A2 sponges miR-665 to enhance LASP1 expression and modulated CRC phenotypes. Thus, circCOL1A2 might be a valuable therapeutic target for CRC, offering novel insight into CRC treatment." 2 Circular RNA XRCC5 aggravates glioma progression by activating CLC3/SGK1 axis via recruiting IGF2BP2. hsa_circ_0058163 hsa_circ_XRCC5 circXRCC5 DOID:0060108 brain glioma glioma RT-qPCR up-regulated Our data concluded that circXRCC5 formed a complex with IGF2BP2 to regulate inflammasome activation and tumor growth via CLC3/SGK1 axis. 2 Fuzheng Kang-Ai inhibits NSCLC cell proliferation via regulating hsa_circ_0048091/hsa-miR-378g/ARRDC3 pathway. hsa_circ_0048091 hsa_circ_PALM circ_0048091 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" down-regulated "It also shows that FZKA inhibits NSCLC cell proliferation through hsa_circ_0048091/hsa-miR-378g/ARRDC3 pathway, uncovering a novel mechanism by which FZKA controls human NSCLC cell growth." 1 ATF4-mediated circTDRD3 promotes gastric cancer cell proliferation and metastasis by regulating the miR-891b/ITGA2 axis and AKT signaling pathway. hsa_circ_0003441 hsa_circ_TDRD3 circTDRD3 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated ATF4-mediated circTDRD3 overexpression modulates the proliferation and metastasis of GC cells through the miR-891b/ITGA2 axis in a positive feedback manner. 1 "Inhibition of circ_0000231 suppresses oxidized low density lipoprotein-induced apoptosis, autophagy and inflammation in human umbilical vein endothelial cells by regulating miR-590-5p/PDCD4 axis." hsa_circ_0000231 hsa_circ_ARHGAP12 circ_0000231 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Downregulation of circ_0000231 suppresses HUVECs from ox-LDL-induced injury partially through regulating miR-590-5p/PDCD4 axis via competing endogenous RNA mechanism, showing a novel potential target for the pathology and treatment of endothelial injury in AS." 2 O-GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/beta-catenin signalling. - hsa_circ_CLNS1A circCLNS1A DOID:687 hepatoblastoma hepatoblastoma RT-qPCR up-regulated This study indicates that upregulated protein level of O-GlcNAcylated LARP1 mediated by circCLNS1A promotes the tumorigenesis and progression of HB through LARP1/DKK4/beta-catenin axis. 1 Downregulation of circ_PLXND1 inhibits tumorigenesis of non-small cell lung carcinoma via miR-1287-5p/ERBB3 axis. hsa_circ_0067301 hsa_circ_PLXND1 circ_PLXND1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_PLXND1 knockdown impeded NSCLC progression through modulating the miR-1287-5p/ERBB3 axis, indicating a promising molecular target for NSCLC treatment." 1 Highly-expressed circ_0129657 inhibits proliferation as well as promotes apoptosis and inflammation in HBMECs after oxygen-glucose deprivation via miR-194-5p/GMFB axis. hsa_circ_0129657 hsa_circ_IQGAP2 circ_0129657 DOID:6713 cerebrovascular disease stroke RT-qPCR down-regulated "In conclusion, our findings suggest that circ_0129657 can inhibit cell proliferation and promote apoptosis and inflammatory factor secretion in HBMECs after oxygen-glucose deprivation via miR-194-5p/GMFB axis, providing evidence that circ_0129657 has the potential as a useful biological molecular marker in the diagnosis of stroke." 1 CircRNA circSLIT2 is a novel diagnostic and prognostic biomarker for gastric cancer. hsa_circ_0009113 hsa_circ_SLIT2 circSLIT2 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Increased circSLIT2 accumulation may serve as a novel diagnostic and prognostic biomarker for GC. 1 "Circ_RBM23 knockdown suppresses chemoresistance, proliferation, migration and invasion of sorafenib-resistant HCC cells through miR-338-3p/RAB1B axis." hsa_circ_0000524 hsa_circ_RBM23 Circ_RBM23 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_RBM23 promoted chemoresistance, malignant proliferation, migration and invasion of SR HCC cells by modulating miR-338-3p/RAB1B axis." 2 Circular RNA circAKIRIN2 participates in the process of stress-induced immunosuppression affecting immune response to infectious bursal disease virus vaccine in chicken. - gga_circ_AKIRIN2 circAKIRIN2 DOID:3091 acinetobacter infectious disease infectious bursal disease RT-qPCR up-regulated "In conclusion, circAKIRIN2 is a key regulatory factor for stress-induced immunosuppression affecting the IBDV vaccine immune response, and this study can provide a new perspective for exploring the molecular regulatory mechanisms of stress-induced immunosuppression affecting immune response." 1 Circular RNA circTNIK promotes tumor progression and metastasis in gastric cancer by regulating ZEB2. - hsa_circ_TNIK circTNIK DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Overall, our study demonstrates how circTNIK regulates gastric cancer progression and metastasis by sponging miR-138-5p to modulate the expression of ZEB2." 1 EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling. hsa_circ_0065214 hsa_circ_SCAP circSCAP DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "In conclusion, this study demonstrates that circSCAP is significantly upregulated in NSCLC cell lines and tissues and elucidates that circSCAP facilitates NSCLC progression by sponging miR-7 and upregulating SMAD2." 2 Circular RNA Dipeptidyl Peptidase 4 (circDPP4) Stimulates the Expression of Glutamate Dehydrogenase 1 to Contribute to the Malignant Phenotypes of Prostate Cancer by Sponging miR-497-5p. hsa_circ_0056881 hsa_circ_DPP4 circDPP4 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated "CircDPP4 facilitated PCa process by mediating the miR-497-5p/GLUD1 axis, providing a possible therapy target for PCa." 3 Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells via regulating miR-135a-5p/stat1 axis. - - "ciRS-7, CDR1as" DOID:1733 cryptosporidiosis cryptosporidiosis RT-qPCR up-regulated Further study revealed that ciRS-7 could sponge miR-135a-5p to positively regulate the protein levels of STAT1 and phosphorylated STAT1 (p-STAT1) and thus promote C. parvum propagation in HCT-8 cells. 1 "CircRBM33 promotes migration, invasion and mediates osimertinib resistance in non-small cell lung cancer cell line." hsa_circ_0001772 hsa_circ_RBM33 circRBM33 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, RNA-seq" up-regulated "CircRBM33 may combine with DNMT1, and regulate the resistance of H1975 osimertinib-resistant cells to osimertinib that mediated by IL6." 1 The regulation of circRNA_kif26b on alveolar epithelial cell senescence via miR-346-3p is involved in microplastics-induced lung injuries. - mmu_circ_kif26b circRNA_kif26b DOID:850 lung disease lung injury RT-qPCR up-regulated "Overall, circ_kif26b mediates alveolar epithelial cell senescence through miR-346-3p and participates in PS-MPs-induced lung inflammation." 1 A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer. hsa_circ_0133744 hsa_circ_INSIG1 circINSIG1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circINSIG1 presents an epigenetic mechanism which provides insights into the crosstalk between hypoxia and cholesterol metabolism, and provides a promising therapeutic target for the treatment of CRC." 1 Combination of hsa_circ_0004674 and lncRNA OIP5_AS1 as a novel clinical biomarker used to predict prognosis in patients with osteosarcoma. hsa_circ_0004674 hsa_circ_ADAM22 circ_0004674 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "In conclusion, the combination of hsa_circ_0004674 and lncRNA OIP5-AS1 may be used as a better biomarker than traditional biomarkers, such as ALP, in a clinical setting." 2 m(6)A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression. hsa_circ_0004680 hsa_circ_CCT3 circ-CCT3 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated Circ-CCT3 was significantly up-regulated in HCC and promoted liver cancer development via miR-378a-3p-FLT1 axis. It was also found that circ-CCT3 was under m A-modification mediated by ALKBH5 and METTL3. 3 hsa_circ_0006916 Exerts Effect on Amyloid Beta-Induced Neuron Injury by Targeting miR-217/HOMER1. hsa_circ_0006916 hsa_circ_HOMER1 circ_0006916 DOID:231 motor neuron disease neuron injury RT-qPCR up-regulated CircHOMER1 (hsa_circ_0006916) ameliorates the fAbeta42-induced cell injury via the miR-217/HOMER1 axis. 1 Circ_0004585 Facilitates Tumorigenesis of Colorectal Cancer Via Modulating the miR-338-3p/ZFX Axis and Activating the MEK/ERK Pathway. hsa_circ_0004585 hsa_circ_KIAA1199 circ_0004585 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0004585 facilitated CRC progression through modulating miR-338-3p/ZFX/MEK/ERK pathway, which might provide a potential therapeutic target for CRC." 3 CircHECTD1 promoted MIRI-associated inflammation via inhibiting miR-138-5p and upregulating ROCK2. - hsa_circ_HECTD1 CircHECTD1 DOID:2316 brain ischemia Myocardial ischemia-reperfusion injury RT-qPCR up-regulated "Our research suggested that the circHECTD1-modulated miR-138-5p suppressing is responsible for ROCK2 activation during H/R-induced inflammatory response, providing a novel insight into MIRI-associated inflammation." 1 CircZfp609 contributes to cerebral infarction via sponging miR-145a-5p to regulate BACH1. mmu_circ_0001797 mmu_circ_Zfp609 CircZfp609 DOID:807 carotid artery occlusion middle cerebral artery occlusion RT-qPCR up-regulated circZfp609 might promote cerebral infarction by regulating the miR-145a-5p/BACH1 pathway. 1 Aberrant expression of circular RNA DHPR facilitates tumor growth and metastasis by regulating the RASGEF1B/RAS/MAPK axis in hepatocellular carcinoma. hsa_circ_0069249 hsa_circ_DHPR - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "We confirmed that circDHPR overexpression inhibited HCC growth and metastasis by sponging miR-3194-5p to upregulate the expression of RASGEF1B, which is regarded as a suppressor of the Ras/MAPK signaling pathway." 1 Circ_0058058 Drives the Malignant Phenotypes and Immune Evasion of Pancreatic Cancer by the MicroRNA-557-Dependent Regulation of PDL1. hsa_circ_0058058 hsa_circ_ATIC circ_0058058 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "Our findings suggested that circ_0058058 served as miR-557 sponge to upregulate PDL1, thereby triggering PC proliferation, invasion, angiogenesis, and immune escape." 1 CircHIPK2 facilitates phenotypic switching of vascular smooth muscle cells in hypertension. - hsa_circ_HIPK2 circHIPK2 DOID:10763 hypertension hypertension RT-qPCR up-regulated "Functional studies showed that circHIPK2 promoted the Angiotensin II (AngII)-induced VSMC phenotype switching by acting as the sponge of miR-145-5p, thereby upregulating the expression of a disintegrin and metalloprotease (ADAM) 17." 1 CircRNF10-DHX15 interaction suppressed breast cancer progression by antagonizing DHX15-NF-kappaB p65 positive feedback loop. hsa_circ_0028899 hsa_circ_RNF10 circRNF10 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "CircRNF10-DHX15 interaction suppressed the DHX15-NF-kB p65 positive feedback loop, thereby inhibiting BC progression." 3 Circular MTHFD2L RNA-encoded CM-248aa inhibits gastric cancer progression by targeting the SET-PP2A interaction. hsa_circ_0069982 hsa_circ_MTHFD2L circMTHFD2L DOID:10534 stomach cancer gastric cancer "RT-qPCR, RNA-seq" down-regulated Our discovery revealed that CM-248aa could be a potential prognostic biomarker and endogenous therapeutic option for GC. 1 Circular RNA Ubiquitin-associated Protein 2 Silencing Suppresses Bladder Cancer Progression by Downregulating DNA Topoisomerase 2-alpha Through Sponging miR-496. hsa_circ_0003141 hsa_circ_UBAP2 circUBAP2 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Silencing of circUBAP2 could suppress BC growth, invasion, migration, and aerobic glycolysis by the miR-496/TOP2A axis, suggesting a promising target for the molecular targeted therapies of BC." 1 Mmu_circ_0000037 inhibits the progression of acute pancreatitis by miR-92a-3p/Pias1 axis. mmu_circ_0000037 mmu_circ_SMPDL3B circ_0000037 DOID:2913 acute pancreatitis acute pancreatitis RT-qPCR down-regulated "Mmu_circ_0000037 relieves caerulein-induced inflammatory injury in MPC-83 cells by targeting miR-92a-3p/Pias1 axis, providing a theoretical basis for the treatment of AP." 1 CircSmox knockdown alleviates PC12 cell apoptosis and inflammation in spinal cord injury by miR-340-5p/Smurf1 axis. - hsa_circ_Smox circSmox DOID:319 spinal cord disease spinal cord injury RT-qPCR up-regulated "CircSmox enhances LPS-induced apoptosis and inflammation via miR-340-5p/Smurf1 axis, providing an exciting view of the potential involvement of circSmox in SCI pathogenesis." 1 CircRNA ZKSCAN1 promotes lung adenocarcinoma progression by miR-185-5p/TAGLN2 axis. hsa_circ_0001727 hsa_circ_ZKSCAN1 circ-ZKSCAN1 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated Circ-ZKSCAN1 promoted LUAD tumorigenesis and DDP resistance by regulating miR-185-5p/TAGLN2 axis. 1 Propofol mediates non-small cell lung cancer growth in part by regulating circ_0003028-related mechanisms. hsa_circ_0003028 hsa_circ_FUT8 circ_0003028 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Propofol-mediated inhibiting effect on NSCLC growth partly depended on the circ_0003028/miR-1305/CORO1C axis. 3 Prognostic value of circWWC3 as a novel survival_related biomarker for clear cell renal cell carcinoma. hsa_circ_0001910 hsa_circ_WWC3 circWWC3 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated "In conclusion, high circWWC3 expression is an independent risk factor affecting patient prognosis, and is expected to be an important prognostic biomarker and novel therapeutic target for patients with ccRCC." 1 Circ-ABCC1 enhances radioresistance of breast cancer cells via miR-627-5p/ABCC1 axis. hsa_circ_0003427 hsa_circ_ABCC1 circ-ABCC1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "In conclusion, Circ-ABCC1 aggravates the radioresistance of BC cells by targeting the miR-627-5p/ABCC1 axis." 1 Circular RNA EPHA3 suppresses progression and metastasis in prostate cancer through the miR-513a-3p/BMP2 axis. hsa_circ_0066596 hsa_circ_EPHA3 circEPHA3 DOID:10283 prostate cancer prostate cancer RT-qPCR down-regulated "As a tumor suppressor, circEPHA3 inhibited the proliferation and metastasis of PCa cells through the miR-513a-3p/BMP2 axis, suggesting that circEPHA3 might be a potential therapeutic target for PCa." 1 CircKIF4A combines EIF4A3 to stabilize SDC1 expression to activate c-src/FAK and promotes TNBC progression. - hsa_circ_KIF4A circKIF4A DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "CircKIF4A interacts with EIF4A3 to stabilize SDC1 mRNA, which activates the c-src/FAK signaling pathways and promotes TNBC progression. This may provide a potential therapy for TNBC treatment." 2 EIF4A3-induced circZFAND6 promotes breast cancer proliferation and metastasis through the miR-647/FASN axis. - hsa_circ_ZFAND6 circZFAND6 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated EIF4A3-induced circZFAND6 up-regulation promoted proliferation and metastasis of breast cancer through the miR-647/FASN axis. 1 The Emerging Role of Circular RNA Homeodomain Interacting Protein Kinase 3 and Circular RNA 0046367 through Wnt/Beta-Catenin Pathway on the Pathogenesis of Nonalcoholic Steatohepatitis in Egyptian Patients. hsa_circ_0046367 hsa_circ_FASN circ_0046367 DOID:80547 non-alcoholic steatohepatitis nonalcoholic steatohepatitis RT-qPCR up-regulated "our results imply that miRNA-29a can be investigated as a target for circRNA-HIPK3, while miRNA-34a can be investigated as a target for circRNA-0046367, and that circRNA-HIPK3 and circRNA-0046367 may have emerging roles that can affect the pathogenesis of nonalcoholic steatohepatitis through the Wnt/beta-catenin pathway and thus be used as therapeutic targets for the disease." 1 Circ_0001387 regulates SKA2 to accelerate breast cancer progression through miR-136-5p. hsa_circ_0001387 hsa_circ_WHSC1 circ_0001387 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Our study indicated that circ_0001387 contributed to BC cell progression through miR-136-5p/SKA2 axis. 2 Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR-1343-3p/Bcl-3 axis through TGFbeta/Smad3/EMT signaling. hsa_circ_0088036 hsa_circ_SUSD1 circ_0088036 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated "In conclusion, hsa_circ_0088036 functions as an oncogene by targeting the miR-1343-3p/Bcl-3 axis via TGFbeta/Smad3/EMT signaling pathway." 1 ARID1A Inactivation Increases Expression of circ0008399 and Promotes Cisplatin Resistance in Bladder Cancer. hsa_circ_0008399 hsa_circ_RBM3 circ0008399 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Importantly, EIF4A3-IN-2 specifically inhibited the activity of EIF4A3 to reduce circ0008399 production and restored the sensitivity of ARID1A inactivated BC cells to CDDP." 1 Downregulation of ciRNA-Kat6b in dorsal spinal horn is required for neuropathic pain by regulating Kcnk1 in miRNA-26a-dependent manner. - mmu_circ_Kat6b ciRNA-Kat6b DOID:0080809 chronic asthma chronic constrictive injury "RT-qPCR, RNA-seq" down-regulated "The ciRNA-Kat6b/miRNA-26a/Kcnk1 pathway in dorsal horn neurons regulates the development and maintenance of neuropathic pain, ciRNA-Kat6b may be a potential new target for analgesic and treatment strategies." 1 Comprehensive analysis and identification of the circ_0084615/miR-451a/MEF2D axis in benzo(a)pyrene exposed tumor cells in hepato-carcinogenesis. hsa_circ_0084615 hsa_circ_ASPH circ_0084615 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Therefore, we performed integrated bioinformatics analysis and molecular experiments to establish the circ_0084615/miR-451a/MEF2D pathway, which provided a better understanding of the adverse effects of fried food preference on human health." 2 "A Novel circ_0104345/miR-876-3p/ZBTB20 Axis Regulates the Proliferation, Migration, Invasion, and Apoptosis of Breast Cancer Cells." hsa_circ_0104345 hsa_circ_IQCH circ_0104345 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "In this study, we demonstrated, for the first time, the crucial regulation of the new circ_0104345/miR-876-3p/ZBTB20 axis in the biological phenotypes of BC cells." 2 "Circ_0002984 promotes proliferation, migration and inflammatory cytokine secretion and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes by inducing PCSK6 through miR-543." hsa_circ_0002984 hsa_circ_ARHGAP32 circ_0002984 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR up-regulated "Circ_0002984 promoted RAFLS proliferation, migration and inflammatory cytokine secretion and inhibited apoptosis by binding to miR-543 to induce PCSK6 production, providing a potential target for RA therapy." 1 Exosomal circ-AHCY promotes glioblastoma cell growth via Wnt/beta-catenin signaling pathway. hsa_circ_0059914 hsa_circ_AHCY circ-AHCY DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated Exosomal circ-AHCY forms a positive feedback loop with Wnt/beta-catenin signaling pathway to promote GBM cell growth. 1 CircREOS suppresses lipid synthesis and osteosarcoma progression through inhibiting HuR-mediated MYC activation. hsa_circ_0085535 hsa_circ_MYC circREOS DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "Taken together, these results indicate that circREOS suppress lipid synthesis and OS progression through inhibiting HuR-mediated MYC activation, providing a potential therapeutic target for OS." 1 [Effect of circRASA2 targeting miR-543/TRAF6 axis on LPS-induced periodontal ligament cell proliferation and osteogenic differentiation]. - hsa_circ_RASA2 circRASA2 DOID:824 periodontitis periodontitis RT-qPCR down-regulated "circRASA2 accelerated the pathological process of periodontitis in vitro through miR-543/TRAF6 axis, and might improve periodontitis by targeting down the expression of circRASA2." 1 Knockdown of circMFN2 inhibits cell progression and glycolysis by miR-198/CUL4B pathway in ovarian cancer. hsa_circ_0009910 hsa_circ_MFN2 circMFN2 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated CircMFN2 repressed OC progression by regulating the miR-198/CUL4B axis. 2 METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6. hsa_circ_0002696 hsa_circ_METTL9 circ-METTL9 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Taken together, our findings highlight a novel oncogenic function of circ-METTL9 in CRC progression via circ-METTL9/miR-551b-5p/CDK6 axis, which may serve as a prognostic biomarker and therapeutic target for CRC patients." 1 CircRTTN upregulates EPHA2 to aggravate the malignant process of melanoma via sponging miR-890. hsa_circ_0108830 hsa_circ_RTTN circRTTN DOID:1909 melanoma melanoma RT-qPCR up-regulated Our findings demonstrated that circRTTN mediated melanoma progression via regulating the miR-890/ EPHA2 axis. 1 "Hsa_circ_0002496 promotes the growth, angiogenesis, and stemness of breast cancer cells via miR-433-3p/YWHAZ cascade." hsa_circ_0002496 hsa_circ_APPBP2 circ_0002496 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0002496 participated in the malignant procession of BC by miR-433-3p/YWHAZ regulation cascade. 1 Hsa_circ_0060467 promotes breast cancer liver metastasis by complexing with eIF4A3 and sponging miR-1205. hsa_circ_0060467 hsa_circ_MYBL2 circ_0060467 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Our findings showed that circMYBL2 promoted the tumorigenesis and aggressiveness of BC through the circMYBL2/miR-1205/E2F1 and circMYBL2/eIF4A3/E2F1 axes, which may provide a novel targeted therapy for patients with BCLM." 1 Mechanism of hypoxia-induced exosome circ_0051799 regulating the progression of lung adenocarcinoma. hsa_circ_0051799 hsa_circ_BAX circ_0051799 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated In vitro and in vivo assays had shown that circ_0051799 could affect the proliferation and metastasis of LUAD through targeting miR-214-3p mediated IGF2BP3 regulated JAK/STAT pathway. 1 Translation of circHGF RNA encodes an HGF protein variant promoting glioblastoma growth through stimulation of c-MET. hsa_circ_0080914 hsa_circ_HGF circHGF DOID:3073 brain glioblastoma multiforme glioblastoma RT-qPCR up-regulated These results reveal an alternative mechanism of c-MET activation via a circular RNA encoded HGF protein variant which is relevant in GBM biology. 1 Circular RNA circSEMA5A facilitates colorectal cancer development by regulating microRNA-195-5p to target CCNE1 axis. hsa_circ_0071803 hsa_circ_SEMA5A circSEMA5A DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated "CircSEMA5A facilitates CRC cell malignancy and tumor growth through sponging miR-195-5p to upregulate CCNE1, thus providing a new direction for CRC diagnosis and targeted therapy." 2 Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression. hsa_circ_0003747 hsa_circ_ALS2CR8 circ_0003747 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "In conclusion, circ_0003747 facilitated the biological progression of TC by modulating the miR-338-3p/PLCD3 axis, and it may be a new target for TC treatment." 1 CircRNA7632 down-regulation alleviates endothelial cell dysfunction in Kawasaki disease via regulating IL-33 expression. - hsa_circ_RNA7632 circRNA7632 DOID:13378 Kawasaki disease kawasaki disease "RT-qPCR, RNA-seq" down-regulated Circ7632 down-regulation could alleviate EndoMT likely through decreasing IL-33 expression. The circ7632 may become a potential therapeutic target for KD. 1 Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the Hippo-YAP signaling pathway. hsa_circ_0007552 hsa_circ_RILPL1 circRILPL1 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated Our results demonstrated that circRILPL1 promoted the proliferation and metastasis of NPC through activating the Hippo-YAP signaling pathway by binding to both ROCK1 and IPO7. 1 Myc derived circRNA promotes triple-negative breast cancer progression via reprogramming fatty acid metabolism. hsa_circ_0085533 hsa_circ_MYC circMyc DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer RT-qPCR up-regulated "Collectively, our findings characterize a novel Myc-derived circRNA controlling TNBC tumorigenesis via regulation of metabolic reprogramming, implying a promising therapeutic target." 1 Circ_0005615 restrains the progression of multiple myeloma through modulating miR-331-3p and IGF1R regulatory cascade. hsa_circ_0005615 hsa_circ_NFATC3 circ_0005615 DOID:9538 multiple myeloma myeloma RT-qPCR up-regulated Circ_0005615 downregulation blocked MM development by targeting miR-331-3p/IGF1R axis. 2 "Functional Characterisation of the Circular RNA, circHTT(2-6), in Huntington Disease." hsa_circ_0001392 hsa_circ_HTT circHTT DOID:12858 Huntington disease huntington disease RT-qPCR up-regulated "As these phenotypic and genotypic changes resemble those observed in HD patients, our results suggest that circHTT(2-6) may play a functional role in the pathophysiology of this disease." 1 Circ_0026466 knockdown protects human bronchial epithelial cells from cigarette smoke extract-induced injury by promoting the miR-153-3p/TRAF6/NF-kappaB pathway. hsa_circ_0026466 hsa_circ_KRT8 circ_0026466 DOID:850 lung disease cigarette smoke extract-induced injury RT-qPCR up-regulated "Circ_0026466 absence protected against CSE-triggered 16HBE cell injury by activating the miR-153-3p/TRAF6/NF-kappaB pathway, providing a potential therapeutic target for COPD." 1 hsa_circ_0051428 Facilitates the Progression of Thyroid Cancer by Sponging miR-1248 to Up-Regulate FN1. hsa_circ_0051428 hsa_circ_RELB circ_0051428 DOID:1781 thyroid gland cancer thyroid cancer RT-qPCR up-regulated "circ_0051428 targeted miR-1248 to modulate FN1 expression, thereby facilitating the malignant progression of TC, which contributed to the understanding of the molecular mechanism of TC development." 1 Circular RNA circARHGEF28 inhibited the progression of prostate cancer via the miR-671-5p/LGALS3BP/NF-kappaB axis. hsa_circ_0005777 hsa_circ_ARHGEF28 circARHGEF28 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated Our findings revealed that circARHGEF28/miR-671-5p/LGALS3BP/NF-¦ĘB may be an important axis that regulates PCa progression. 1 Targeting a novel circITCH/miR-421/BTG1 axis is effective to suppress the malignant phenotypes in hepatocellular carcinoma (HCC) cells. - hsa_circ_ITCH circITCH DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "In conclusion, this study identified a novel circITCH/miR-421/BTG1 axis that restrained the development of HCC, and our findings provided novel biomarkers for the treatment of this disease." 5 Circ_0069094 regulates malignant phenotype and paclitaxel resistance in breast cancer cells via targeting the miR-136-5p/YWHAZ axis. hsa_circ_0069094 hsa_circ_S100P circ_0069094 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Circ_0069094 silencing improved PTX sensitivity in breast cancer progression through competitively sponging miR-136-5p. 4 Circular circRANGAP1 Contributes to Non-small Cell Lung Cancer Progression by Increasing COL11A1 Expression Through Sponging miR-653-5p. hsa_circ_0063526 hsa_circ_RANGAP1 circRANGAP1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircRANGAP1 silencing might suppress NSCLC cell malignant biological behaviors, at least in part, through the miR-653-5p/COL11A1 axis." 1 circRNA_0001006 predicts prognosis and regulates cellular processes of triple-negative breast cancer via miR-424-5p. hsa_circ_0001006 hsa_circ_RTN4 circ_0001006 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated Upregulated circ_0001006 in TNBC served as a poor prognosis predictor and tumor promoter via negatively regulating miR-424-5p. 2 Circpsmc3 Inhibits Colorectal Cancer Cell Growth and Migration By Controlling Mir-31-5p/Yap/Beta-Catenin. - hsa_circ_PSMC3 circPSMC3 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated "Our work was the first time to probe the potential regulatory effects of CircPSMC3 in CRC, and these above results uncovered that CircPSMC3 inhibited CRC cell growth and migration through regulating miR-31-5p/YAP/beta-catenin. " 1 Circ_0087378 intensifies the malignant behavior of non-small cell lung cancer cells in vitro by facilitating DDR1 via sponging miR-199a-5p. hsa_circ_0087378 hsa_circ_NTRK2 circ_0087378 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ_0087378 promotes the malignant behavior of NSCLC cells_n vitro_y facilitating DDR1 via sponging miR-199a-5p. It may be a promising target for treatment. 1 CircZNF215 promotes tumor growth and metastasis through inactivation of the PTEN/AKT pathway in intrahepatic cholangiocarcinoma. - hsa_circ_ZNF215 "circZNF215, cZNF215" DOID:4928 intrahepatic cholangiocarcinoma intrahepatic cholangiocarcinoma RT-qPCR up-regulated Our study demonstrates that cZNF215 facilitates iCCA progression and metastasis by regulating the PTEN/AKT pathway and may serve as a novel prognostic predictor in patients with iCCA. 1 "Hsa_circ_0002019 promotes cell proliferation, migration, and invasion by regulating TNFAIP6/NF-kappaB signaling in gastric cancer." hsa_circ_0002019 hsa_circ_FOXRED1 circ_0002019 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Circ_0002019 accelerated the proliferation, migration, and invasion by regulating TNFAIP6/NF-kB pathway, suggesting circ_0002019 could be a key regulatory factor in GC progression." 1 Circular RNA AGAP1 Stimulates Immune Escape and Distant Metastasis in Renal Cell Carcinoma. hsa_circ_0058792 hsa_circ_AGAP1 circAGAP1 DOID:4450 renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "Collectively, our findings demonstrate that circAGAP1 exerts a tumor suppressor function through miR-216a-3p/MKNK2 during the immune escape and distant metastasis in ccRCC, and suggest that circAGAP1 may be a novel prognostic marker and therapeutic target for ccRCC." 1 A circular RNA produced by LRBA promotes cirrhotic mouse liver regeneration through facilitating the ubiquitination degradation of p27. mmu_circ_0018031 mmu_circ_LRBA circLRBA DOID:409 liver disease liver regeneration RT-qPCR up-regulated We conclude that circLRBA is a novel growth promoter in liver regeneration and a potential therapeutic target related to deficiency of cirrhotic liver regeneration. 1 "Circular RNA hsa_circ_0005239 contributes to hepatocellular carcinoma cell migration, invasion, and angiogenesis by targeting the miR-34a-5p/PD-L1 axis." hsa_circ_0005239 hsa_circ_GFRA1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "These results revealed the role of hsa_circ_0005239 and the hsa_circ_0005239/miR-34a-5p/PD-L1 axis in HCC, providing a potential diagnostic biomarker and therapeutic target for HCC." 2 Hsa_circ_0111738 Inhibits Tumor Progression and Angiogenesis in Multiple Myeloma by Sponging miR-1233-3p to Regulate HIF-1 Signaling Pathway. hsa_circ_0111738 hsa_circ_SOX13 circ_0111738 DOID:9538 multiple myeloma myeloma RT-qPCR down-regulated Our data suggest that circ_0111738 functioned as a competing endogenous RNA (ceRNA) and suppressed the oncogenic function of miR-1233-3p in MM by inactivating the HIF-1 pathway. 1 Circular RNA hsa_circ_0084054 promotes the progression of periodontitis with diabetes via the miR-508-3p/PTEN axis. hsa_circ_0084054 hsa_circ_ADAM32 - DOID:9351 diabetes mellitus gestational diabetes mellitus "RT-qPCR, RNA-seq" up-regulated "hsa_circ_0084054 can aggravate inflammation and promote the progression of periodontitis with diabetes by regulating miR-508-3p/PTEN signaling axis, which may serve as a new target for the intervention of periodontitis with diabetes." 1 The Novel Circular RNA circTRIO Silence Inhibits the Progression of Laryngeal Squamous Cell Carcinoma. hsa_circ_0005260 hsa_circ_TRIO circTRIO DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated Upregulated circTRIO expression levels may play an important role in the tumorigenesis and development of LSCC. 1 Circular RNA-AnnexinA7 accelerates cisplatin resistance in non-small cell lung cancer via modulating microRNA-545-3p to mediate Cyclin D1. - hsa_circ_ANXA7 Circ-ANXA7 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ-ANXA7 enhances DDP resistance in NSCLC via absorbing miR-545-3p to target CCND1 and might be a latent therapeutic target for NSCLC. 1 "Circular non-coding RNA circ_0072088 serves as a ceRNA, targeting the miR-1225-5p/WT1 axis to regulate non-small cell lung cancer cell malignant behavior." hsa_circ_0072088 hsa_circ_ZFR circ_0072088 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0072088 knockdown could inhibit cell growth, migration, invasion, and glycolysis partially by regulating the miR-1225-5p/WT1 axis, thus providing a promising therapeutic target for NSCLC treatment." 3 Induction of perineural invasion in salivary adenoid cystic carcinoma by circular RNA RNF111. hsa_circ_0001982 hsa_circ_RNF111 circ-RNF111 DOID:4866 salivary gland adenoid cystic carcinoma salivary adenoid cystic carcinoma RT-qPCR up-regulated "Taken together, circ-RNF111 stimulates PNI in SACC by miR-361-5p/HMGB2 axis and may serve as a potential therapeutic target for SACC." 1 Circular RNA circDLG1 contributes to HCC progression by regulating the miR-141-3p/WTAP axis. hsa_circ_0007203 hsa_circ_DLG1 circDLG1 DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "circDLG1 participates in the progression of HCC cells by sponging miR-141-3p with WTAP, providing new insight into the treatment of HCC." 3 CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis. - hsa_circ_KDM1B circKDM1B DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "CircKDM1B played a critical role in HCC progression by regulating cell proliferation, migration, invasion and apoptosis. CircKDM1B/miR-1322/PRC1 axis might be a novel therapeutic target of HCC patients." 1 A novel molecular mechanism mediated by circCCDC134 regulates non-small cell lung cancer progression. hsa_circ_0001238 hsa_circ_CCDC134 circCCDC134 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Our study revealed that circCCDC134 was involved in regulating NSCLC progression through the miR-625-5p/NFAT5 pathway, confirming that circCCDC134 might function as the diagnostic and therapeutic target for NSCLC." 1 Circ_0081054 facilitates melanoma development via sponging miR-637 and regulating RAB9A. hsa_circ_0081054 hsa_circ_COL1A2 circ_0081054 DOID:1909 melanoma melanoma RT-qPCR up-regulated All results indicated that circ_0081054 promoted the malignant behaviors of melanoma cells partly by regulating the miR-637/RAB9A molecular axis. 1 Hsa_circ_0007401 regulates gemcitabine resistance of pancreatic cancer through the hsa-miR-6509-3p/fli1 axis. hsa_circ_0007401 hsa_circ_NUP98 circ_0007401 DOID:1793 pancreatic cancer pancreatic cancer "RT-qPCR, microarray" down-regulated This led us to identif ceRNA network mediated by hsa-miR-6509-and FLI1 that is regulated by hsa_circ_0007401. 1 Cigarette Smoke-Induced Gastric Cancer Cell Exosomes Affected the Fate of Surrounding Normal Cells via the Circ0000670/Wnt/beta-Catenin Axis. hsa_circ_0000670 hsa_circ_C16orf72 circ0000670 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Our findings indicated that exosomal circ0000670 promotes cigarette smoke-induced gastric cancer development, which might provide a new basis for the treatment of cigarette smoke-related gastric cancer." 2 Over-expression of hsa_circ_0088214 suppresses tumor progression by inhibiting Akt signaling pathway in osteosarcoma. hsa_circ_0088214 hsa_circ_PAPPA circ_0088214 DOID:3347 osteosarcoma osteosarcoma RT-qPCR down-regulated "Up-regulation of hsa_circ_0088214 suppresses invasion, migration, cisplatin resistance but promoting apoptosis induced by H2O2 by inhibiting Akt signaling pathway in osteosarcoma." 5 Aberrantly Expressed Hsa_circ_0060762 and CSE1L as Potential Peripheral Blood Biomarkers for ALS. hsa_circ_0060762 hsa_circ_CSE1L circ_0060762 DOID:332 amyotrophic lateral sclerosis Amyotrophic lateral sclerosis "RT-qPCR, microarray" up-regulated Hsa_circ_0060762 and CSE1L thus represent novel potential peripheral blood biomarkers and therapeutic targets for ALS. 1 "Smoking-Induced M2-TAMs, via circEML4 in EVs, Promote the Progression of NSCLC through ALKBH5-Regulated m6A Modification of SOCS2 in NSCLC Cells." - hsa_circ_EML4 circEML4 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "This study also reveals that circEML4 in EVs from TAMs acts as a diagnostic biomarker for NSCLC, especially for patients with smoking history." 1 CircBBS9 accelerates the malignant progression of osteosarcoma through sponging miR-485-3p/HMGB1 axis. - hsa_circ_BBS9 circBBS9 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated The findings explained that CircBBS9 promoted the malignant osteosarcomas progression by sponging miR-485-3p/HMGB1 and proposed CircBBS9 as a prognostic biomarker and therapeutic candidate for osteosarcoma patients. 1 Circular RNA circ0001955 promotes cervical cancer tumorigenesis and metastasis via the miR-188-3p/NCAPG2 axis. hsa_circ_0001955 hsa_circ_CSNK1G1 circ0001955 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated circ0001955 promotes CSCC tumorigenesis and metastasis via the miR-188-3p/NCAPG2 axis which would provide an opportunity to search new therapeutic targets for CSCC. 1 Isoliquiritigenin inhibits circ0030018 to suppress glioma tumorigenesis via the miR-1236/HER2 signaling pathway. hsa_circ_0030018 hsa_circ_POSTN circ0030018 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "In conclusion, our study investigated the roles and mechanisms of the ISL on the circ0030018/miR-1236/HER2 pathway in glioma tumorigenesis and progression." 5 The circRNA-0001361/miR-491/FGFR4 axis is associated with axillary response evaluated by ultrasound following NAC in subjects with breast cancer. hsa_circ_0001361 hsa_circ_FNDC3B circRNA-0001361 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Our study suggested that the up-regulation of hsa_circRNA-0001361 could up-regulate the expression of FGFR4 via sponging the expression of miR-491-5p, resulting in the alleviated axillary response after neoadjuvant chemotherapy (NAC) in breast cancer." 1 The Circular RNA circFOXK2 Enhances the Tumorigenesis of Non-Small Cell Lung Cancer Through the miR-149-3p/IL-6 Axis. - hsa_circ_FOXK2 circFOXK2 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer "RT-qPCR, microarray" up-regulated "Overall, this research verified that circFOXK2 enhances the tumorigenesis of NSCLC through the miR-149-3p/IL-6 axis." 2 circSKA3 promotes colorectal cancer metastases through miR-1238 and methylation. - hsa_circ_SKA3 circSKA3 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "circSKA3 could increase the expression ofYTHDF2 through sponging miR-1238 to decrease the methylation of STAT5A, which could provide a novel target for CRC treatment." 2 "Regulation of a Novel CircTRRAP/miR-761/MAP3K2 CeRNA Cascade in Inflammation, Apoptosis, and Oxidative Stress in Human AC16 Cardiomyocytes under Hypoxia Conditions." hsa_circ_0081241 hsa_circ_TRRAP circTRRAP DOID:1287 cardiovascular system disease cardiomyocyte injury RT-qPCR up-regulated circTRRAP can protect AC16 cardiomyocytes from hypoxia-evoked injury through the miR-761/MAP3K2 axis. 1 A novel protein encoded by circUBE4B promotes progression of esophageal squamous cell carcinoma by augmenting MAPK/ERK signaling. hsa_circ_0005199 hsa_circ_UBE4B circUBE4B DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, microarray" up-regulated Our study provides new insights into the mechanism of circRNA in the development of ESCC and circUBE4B-173aa has the potential to serve as a biomarker and a novel therapeutic target for ESCC therapy. 1 CREBZF mRNA nanoparticles suppress breast cancer progression through a positive feedback loop boosted by circPAPD4. hsa_circ_0001504 hsa_circ_PAPD4 circPAPD4 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "Our findings firstly illustrated that circPAPD4/miR-1269a/CREBZF/STAT3/ADAR1 positive feedback loop mediated BC progression, and delivering CREBZF mRNA nanoparticles suppressed BC progression in vitro and in vivo, which might provide novel insights into therapeutic strategies for breast cancer." 1 GC_MSC_derived circ_0024107 promotes gastric cancer cell lymphatic metastasis via fatty acid oxidation metabolic reprogramming mediated by the miR_5572/6855_5p/CPT1A axis. hsa_circ_0024107 hsa_circ_MMP1 circ_0024107 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Taken together, the findings of the present study suggest the crucial role of FAO metabolic reprogramming mediated by GC_MSC_derived circ_0024107 in synergistically promoting gastric cancer lymphatic metastasis via miR_5572/6855_5p_CPT1A signaling." 1 Paclitaxel inhibits hepatocellular carcinoma tumorigenesis by regulating the circ_0005785/miR-640/GSK3beta. hsa_circ_0005785 hsa_circ_ANAPC7 circ_0005785 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "PTX restrained HCC tumorigenesis partly via regulating the circ_0005785/miR-640/GSK3beta axis, hinting at a promising therapeutic target for the HCC treatment." 2 CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer. hsa_circ_0000284 hsa_circ_HIPK3 circHIPK3 DOID:11054 urinary bladder cancer bladder cancer RT-qPCR down-regulated "Thus, circHIPK3 may play an important role in bladder cancer by inhibiting VCP-mediated autophagy." 4 CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis. hsa_circ_0001257 hsa_circ_PLXNB2 circPLXNB2 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated "In conclusion, circPLXNB2 was highly expressed in AML patients and cells and modulated tumor progression by regulating the circPLXNB2/miR-654-3p/CCND1 axis, suggested that circPLXNB2 might be a new therapeutic target for AML treatment." 2 Circ-MALAT1 accelerates cell proliferation and epithelial mesenchymal transformation of colorectal cancer through regulating miR-506-3p/KAT6B axis. - hsa_circ_MALAT1 circ-MALAT1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ-MALAT1 promotes cell proliferation, migration, and EMT of CRC cells via the miR-506-3p/KAT6B axis, thereby acting as a novel potential therapeutic target for the treatment of colorectal cancer." 1 Circular RNA DHTKD1 targets miR_338_3p/ETS1 axis to regulate the inflammatory response in human bronchial epithelial cells. - hsa_circ_DHTKD1 circDHTKD1 DOID:2841 asthma Asthma RT-qPCR up-regulated "circDHTKD1 exacerbated LPS-triggered inflammation responses in BEAS-2B cells by regulating ETS1 expression by interacting with miR-338-3p, suggesting that circDHTKD1 may serve as a potential therapeutic target against asthma." 1 Circ_0003356 suppresses gastric cancer growth through targeting the miR-668-3p/SOCS3 axis. hsa_circ_0003356 hsa_circ_PPP5C circ_0003356 DOID:10534 stomach cancer gastric cancer RT-qPCR down-regulated Circ_0003356 impaired GC development through its interaction with the miR-668-3p/SOCS3 axis. 1 Hsa_Circ_0104206 is An Oncogenic circRNA in Colon Cancer by Targeting Mir-188-3p/CCNA2 Axis. hsa_circ_0104206 hsa_circ_CSNK1G1 Circ_0104206 DOID:219 colon cancer colon cancer RT-qPCR up-regulated "In conclusion, Circ_0104206 plays oncogenic roles in CC via the implication of miR-188-3p/CCNA2 network, which further discloses CC pathogenesis and supplies potential markers for CC." 1 Circ_0010235 confers cisplatin resistance in lung cancer by upregulating E2F7 through absorbing miR-379-5p. hsa_circ_0010235 hsa_circ_ALDH4A1 circ_0010235 DOID:1324 lung cancer lung cancer RT-qPCR up-regulated "Circ_0010235 knockdown reduced DDP resistance and tumor growth via miR-379-5p/ E2F7 axis in lung cancer, suggesting an effective therapeutic target for lung cancer patients." 2 Circular RNA hsa_circ_0064559 affects tumor cell growth and progression of colorectal cancer. hsa_circ_0064559 hsa_circ_KCNH8 - DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, microarray" up-regulated The hsa_circ_0064559 may be a potential biomarker for early diagnosis or prognosis of CRC and a novel drug target for CRC therapy. 1 EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway. hsa_circ_0001187 hsa_circ_DOPEY2 circ_0001187 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR down-regulated "Collectively, our findings highlight the potential clinical implications of Circ _0001187 as a key tumor suppressor in AML via the miR-499a-5p/RNF113A/METTL3 pathway." 3 "Circ_0059457 Promotes Proliferation, Metastasis, Sphere Formation and Glycolysis in Breast Cancer Cells by Sponging miR-140-3p to Regulate UBE2C." hsa_circ_0059457 hsa_circ_TASP1 circ_0059457 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Circ_0059457 promoted BC progression via miR-140-3p/UBE2C axis, which provided potential target for the treatment of BC." 1 Circ_ATAD3B inhibits cell proliferation of breast cancer via mediating the miR-570-3p/MX2 axis. - hsa_circ_ATAD3B Circ_ATAD3B DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" down-regulated The tumor suppressor circ_ATAD3B prevents cancer progression by regulating the miR-570-3p/MX2 pathway. 1 Circular RNA hsa_circ_0098181 inhibits metastasis in hepatocellular carcinoma by activating the Hippo signaling pathway via interaction with eEF2. hsa_circ_0098181 hsa_circ_SOX5 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Our study reveals changes in circRNA expression from chronic hepatitis, primary HCC, to metastatic HCC. Further, the QKI5-hsa_circ_0098181-eEF2-Hippo signaling pathway exerts a regulatory role in HCC." 3 CircEGFR reduces the sensitivity of pirarubicin and regulates the malignant progression of triple-negative breast cancer via the miR-1299/EGFR axis. hsa_circ_0080220 hsa_circ_EGFR circEGFR DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "These results revealed circEGFR is a promising biomarker for TNBC diagnosis, therapeutic and prognosis." 1 CircFAT1 promotes the proliferation and invasion of malignant melanoma through miR375-SLC7A11 signal axis. - hsa_circ_FAT1 circFAT1 DOID:1909 melanoma melanoma RT-qPCR up-regulated "circFAT1 promotes the proliferation, invasion and clone formation of malignant melanoma cells by improving the expression level of SLC7A11 via sponging miR-375." 1 Has_circ_0000069 expression in breast cancer and its influences on prognosis and cellular activities. hsa_circ_0000069 hsa_circ_STIL circ_0000069 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated These findings revealed that has_circ_0000069 may be a biomarker for predicting prognosis and a therapeutic target for treating patients with breast cancer. 1 CircMAN1A2 promotes vasculogenic mimicry of nasopharyngeal carcinoma cells through upregulating ERBB2 via sponging miR-940. hsa_circ_0000119 hsa_circ_MAN1A2 circMAN1A2 DOID:9261 nasopharynx carcinoma nasopharyngeal carcinoma RT-qPCR up-regulated "Taken together, the present findings suggest that circMAN1A2 promotes VM formation and progression of NPC through miR-940/ERBB2 axis and further activates the PI3K/AKT/mTOR pathway." 2 The Circular RNA Circ-ANAPC7 as a Biomarker for the Risk Stratification of Myelodysplastic Syndrome. - hsa_circ_ANAPC7 Circ-ANAPC7 DOID:0050908 myelodysplastic syndrome Myelodysplastic syndromes RT-qPCR up-regulated the expression level of circ-ANAPC7 was found to be a promising biomarker for MDS. It may be added to the scoring system to better identify risk groups. 1 Extracellular Vesicles Derived circSH3PXD2A Inhibits Chemoresistance of Small Cell Lung Cancer by miR-375-3p/YAP1. - hsa_circ_SH3PXD2A circSH3PXD2A DOID:5409 lung small cell carcinoma small cell lung cancer RT-qPCR down-regulated Our results manifest that EVs-derived circSH3PXD2A inhibits the chemoresistance of SCLC through miR-375-3p/YAP1 axis. 1 Circular SERPINA3 and its target microRNA-944 as potential biomarkers in hepatitis C virus-induced hepatocellular carcinoma in Egyptian population. hsa_circ_0033074 hsa_circ_SERPINA3 circSERPINA3 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated circSERPINA3 and miR-944 were sensitive molecular markers for early diagnosis of HCC and could be prospective treatment targets for HCV-infected patients to avoid tumor recurrence in HCC cases. 1 Circular RNA Circ_0038467 promotes the maturation of miRNA-203 to increase lipopolysaccharide-induced apoptosis of chondrocytes. hsa_circ_0038467 - circ_0038467 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated Circ_0038467 is highly expressed in OA and it may promote the production of mature miR-203 to increase apoptosis of chondrocytes induced by LPS. 1 Hsa_circ_0023826 protects against glaucoma by regulating miR-188-3p/MDM4 axis. hsa_circ_0023826 hsa_circ_ODZ4 circ_0023826 DOID:1686 glaucoma glaucoma RT-qPCR down-regulated "Overall, circ_0023826 protects against glaucoma by regulating the miR-188-3p/MDM4 axis, and targeted intervention of circ_0023826 expression is a promising therapeutic strategy for the treatment of retinal neurodegeneration." 2 Peripheral Blood-derived CircVPS35L as a Potential Diagnostic Biomarker for Non-small Cell Lung Cancer. - hsa_circ_VPS35L circVPS35L DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated "These findings demonstrate that circVPS35L has great potential as a novel biomarker for the diagnosis of NSCLC, and can be used to distinguish NSCLC from benign lung disease." 1 Effect of circ_0000009 on lung adenocarcinoma progression by regulating PDZD2 in a ceRNA- and RBP- dependent manner. hsa_circ_0000009 hsa_circ_SKI circ_0000009 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR down-regulated "Mechanistically, circ_0000009 promoted the expression of PDZD2 by sponging miR-154-3p." 1 Knockdown of circSOD2 ameliorates osteoarthritis progression via the miR-224-5p/PRDX3 axis. - hsa_circ_SOD2 circSOD2 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated knockdown of circSOD2 may serve as an intervention strategy to alleviate OA progression through modulating miR-224-5p/PRDX3 signaling axis. 1 Circ_0091579 Knockdown Inhibited HCC Proliferation and Glutamine Metabolism Through miR-1270/YAP1 Axis. hsa_circ_0091579 hsa_circ_GPC3 circ_0091579 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Circ_0091579 promoted HCC progression by regulating the miR-1270/YAP1 axis, and our study might offer novel biomarkers and therapeutic targets for HCC." 6 Interaction between the expression of hsa_circRPRD1A and hsa_circHERPUD2 and classical coronary risk factors promotes the development of coronary artery disease. - hsa_circ_RPRD1A circRPRD1A DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, RNA-seq" down-regulated Our findings imply that hsa_circRPRD1A and hsa_circHERPUD2 could be used as biomarkers for the diagnosis of coronary artery disease and provide epidemiological support for the interactions between circRNAs and classical coronary risk factors. 1 Interaction between the expression of hsa_circRPRD1A and hsa_circHERPUD2 and classical coronary risk factors promotes the development of coronary artery disease. - hsa_circ_HERPUD2 hsa_circHERPUD2 DOID:3393 coronary artery disease coronary artery disease "RT-qPCR, RNA-seq" down-regulated Our findings imply that hsa_circRPRD1A and hsa_circHERPUD2 could be used as biomarkers for the diagnosis of coronary artery disease and provide epidemiological support for the interactions between circRNAs and classical coronary risk factors. 1 Hsa_circ_0014784-induced YAP1 promoted the progression of pancreatic cancer by sponging miR-214-3p. hsa_circ_0014784 hsa_circ_HDGF circ_0014784 DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "Taken together, our study found that hsa_circ_0014784 downregulation decremented invasion, proliferation, EMT, and angiogenesis of PC by regulating miR-214-3p/YAP1 signaling." 1 Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression. hsa_circ_0001741 hsa_circ_TNPO3 circ_0001741 DOID:2394 ovarian cancer ovarian cancer RT-qPCR down-regulated Therefore our data suggested that hsa_circ_0001741 upregulation inhibited proliferation of OC through modulatory effects on miR-188-5p/FOXN2 signaling. 2 Exosomal circ_0008285 in follicle fluid regulates the lipid metabolism through the miR-4644/ LDLR axis in polycystic ovary syndrome. hsa_circ_0008285 hsa_circ_CDYL circ_0008285 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome RT-qPCR down-regulated Circ_0008285 can combine with miR-4644 to promote the expression of LDLR and affect the cholesterol metabolism of ovarian granulosa cells in PCOS. 1 Diagnosis of acute myocardial infarction using a combination of circulating circular RNA cZNF292 and clinical information based on machine learning. - hsa_circ_ZNF292 cZNF292 DOID:9408 acute myocardial infarction acute myocardial Infarction RT-qPCR up-regulated "Thus, we identify circulating cZNF292 as a potential biomarker for AMI and construct a prediction model CM + cZNF292.." 1 Anthocyanins improve liver fibrosis in mice by regulating the autophagic flux level of hepatic stellate cells by mmu_circ_0000623. hsa_circ_0000623 hsa_circ_MYO9A circ_0000623 DOID:409 liver disease liver fibrosis RT-qPCR down-regulated Anthocyanins could treat liver fibrosis by modulating circ_0000623/miR-351-5p/TFEB-mediated changes in HSC autophagic flux. 1 EIF4a3-regulated circRABL2B regulates cell stemness and drug sensitivity of lung cancer via YBX1-dependent downregulation of MUC5AC expression. hsa_circ_0064019 hsa_circ_RABL2B circRABL2B DOID:1324 lung cancer lung cancer RT-qPCR down-regulated "In conclusion, our data suggest that circRABL2B counteracts lung cancer progression via MUC5AC/integrin beta4/pSrc/p53 axis, which provides a rationale to enhance the efficacy of anti-MUCs treatment in lung cancer." 1 Exosome-transmitted hsa_circ_0012634 suppresses pancreatic ductal adenocarcinoma progression through regulating miR-147b/HIPK2 axis. hsa_circ_0012634 hsa_circ_TMEM59 circ_0012634 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR down-regulated "Exosomal hsa_circ_0012634 restrained PDAC progression via the miR-147b/HIPK2 pathway, confirming that hsa_circ_0012634 might serve as a diagnosis and treatment biomarker for PDAC." 1 "CircRNA hsa_circ_0000043 acts as a miR-4492 sponge to promote lung cancer progression via BDNF and STAT3 expression regulation in anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed 16HBE Cells." hsa_circ_0000043 hsa_circ_PUM1 - DOID:1324 lung cancer lung cancer "RT-qPCR, microarray" up-regulated "Thus, hsa_circ_0000043 was shown to contribute to the proliferation, malignant transformation ability, migration, and invasion of 16HBE-T cells via miR-4492 sponging and BDNF and STAT3 involvement." 2 CircSNX25 mediated by SP1 promotes the carcinogenesis and development of triple-negative breast cancer. hsa_circ_0004874 hsa_circ_SNX25 circSNX25 DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, RNA-seq" up-regulated Our findings demonstrate that SP1-mediated circSNX25 promotes TNBC carcinogenesis and development. 1 Exploration into Plasma Hsa_circ_0052184 as a New Biomarker of Colorectal Cancer Prognosis. hsa_circ_0052184 hsa_circ_PPP1R12C circ_0052184 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated Circulating hsa_circ_0052184 is a potential bioindicator of CRC outcome. 2 circ_0058063 promotes breast cancer progression by upregulating DLGAP5 via sponging miR-557. hsa_circ_0058063 hsa_circ_ATIC circ_0058063 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated These findings suggest that the circ_0058063/miR-557/DLGAP5 axis is an important regulator of oncogenic function and may be a promising therapeutic target for BC. 1 Hsa_circRNA_0000284 acts as a ceRNA to participate in coronary heart disease progression by sponging miRNA-338-3p via regulating the expression of ETS1. hsa_circ_0000284 hsa_circ_HIPK3 circRNA_0000284 DOID:3393 coronary artery disease coronary heart disease RT-qPCR up-regulated "The expression of hsa_circRNA_0000284 affected proliferation, cycle distribution, aging, and apoptosis in EA-hy926 cells." 2 "Circular RNA CircDHRS3 Aggravates IL-1beta-induced ECM Degradation, Apoptosis, and Inflammatory Response via Mediating MECP2 Expression." hsa_circ_0010024 hsa_circ_DHRS3 circDHRS3 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "CircDHRS3 silencing reduced MECP2 expression via sponging miR-193a-3p, thereby weakening IL-1beta-induced chondrocyte ECM degradation, apoptosis, and inflammatory response." 2 CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability. - hsa_circ_NFATC3 circNFATC3 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated Our findings demonstrate that circNFATC3 promotes GC proliferation by stabilizing IGF2BP3 protein to enhance CCND1 mRNA stability. 1 CircLARP1B promotes pyroptosis of high glucose-induced renal mesangial cells by regulating the miR-578/TLR4 axis. - hsa_circ_LARP1B circLARP1B DOID:557 kidney disease diabetic nephropathy RT-qPCR up-regulated "CircLARP1B/miR-578/TLR4 axis suppressed the proliferation, blocked cell cycle at the G0-G1 phase, promoted pyroptosis, and inflammatory factor release of renal mesangial cells induced by HG." 1 CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis. - hsa_circ_ARF3 CircARF3 DOID:4481 allergic rhinitis allergic rhinitis "RT-qPCR, RNA-seq" down-regulated CircARF3 inhibited cell apoptosis and inflammation via the miR-205-5p/SIRT5 axis in IL-4/IL-13-treated NEpCs and HDM-treated mice. 1 Circular RNA 0016142 Knockdown Induces Ferroptosis in Hepatocellular Carcinoma Cells via Modulation of the MicroRNA-188-3p/Glutathione Peroxidase 4 Axis. hsa_circ_0016142 hsa_circ_PIK3C2B circ_0016142 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "In conclusion, circ_0016142 silencing suppressed HCC cell proliferation by inducing ferroptosis via the miR-188-3p/GPX4 axis." 1 CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension. - hsa_circ_Itgb5 circItgb5 DOID:6432 pulmonary hypertension monocrotaline-induced pulmonary arterial hypertension "RT-qPCR, RNA-seq" up-regulated CircItgb5 promoted the transition of PASMCs to synthetic phenotype by interacting with miR-96-5p and Uba1 protein. 1 Circ-PDZD8 promotes cell growth and glutamine metabolism in non-small cell lung cancer by enriching LARP1 via sequestering miR-330-5p. hsa_circ_0020123 hsa_circ_PDZD8 circ-PDZD8 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated Circ-PDZD8 promotes NSCLC cell growth and glutamine metabolism by increasing LARP1 via competitively targeting miR-330-5p. 9 Silencing of circUSPL1 represses breast cancer progression by targeting miR-1296-5p/MTA1 axis. hsa_circ_0100213 hsa_circ_USPL1 circUSPL1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "CircUSPL1 deficiency repressed BC cell malignant phenotypes through reducing MTA1 via targeting miR-1296-5p, which might provide a theoretical basis for BC treatment." 1 Increased plasma levels of circPTP4A2 and circTLK2 are associated with stroke injury. hsa_circ_0007364 hsa_circ_PTP4A2 circPTP4A2 DOID:6713 cerebrovascular disease stroke injury RT-qPCR up-regulated "These results demonstrate that plasma circPTP4A2 and circTLK2 strongly correlated with severity, subtypes and prognosis of AIS, and they could serve as promising biomarkers." 1 Increased plasma levels of circPTP4A2 and circTLK2 are associated with stroke injury. hsa_circ_0045128 hsa_circ_TLK2 circTLK2 DOID:6713 cerebrovascular disease stroke injury RT-qPCR up-regulated "These results demonstrate that plasma circPTP4A2 and circTLK2 strongly correlated with severity, subtypes and prognosis of AIS, and they could serve as promising biomarkers." 1 NSD2 promotes pressure overload-induced cardiac hypertrophy via activating circCmiss1/TfR1/ferroptosis signaling. - mmu_circ_Cmss1 circCmss1 DOID:114 heart disease cardiac hypertrophy "RT-qPCR, microarray" up-regulated This study highlights the significance of NSD2 activation of circCmss1/EIF4A3/TfR1 as therapeutic targets for treating pathological myocardial hypertrophy. 1 Hsa_circ_0007031 promotes the proliferation and migration of osteosarcoma cells by sponging miR-196a-5p to regulate the HOXB6. hsa_circ_0007031 hsa_circ_TUBGCP3 circ_0007031 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "In summary, our data unveiled that hsa_circ_0007031/miR-196a-5p/HOXB6 axis-mediated cytokine-cytokine receptor interaction facilitates the progression of OS and maintains the properties of tumor stem cells, which could be a promising therapeutic target for OS." 2 Circ_0000033 up-regulates NUAK2 by sequestering miR-378a-3p to promote breast tumorigenesis. hsa_circ_0000033 hsa_circ_CEP85 circ_0000033 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Overall, circ_0000033 up-regulates NUAK2 through sequestration miR-378a-3p, which promoted breast tumorigenesis, suggesting circ_0000033 is a promising therapeutic target for BC treatment." 1 Hsa_circ_0005085 may suppress cutaneous squamous cell carcinoma growth and metastasis through targeting the miR-186-5p/LAMC1 axis. hsa_circ_0005085 hsa_circ_ASAP2 circ_0005085 DOID:1749 squamous cell carcinoma squamous cell carcinoma RT-qPCR down-regulated "In our study, hsa_circ_0005085 might inhibit CSCC development by targeting the miR-186-5p/LAMC1 axis, which might provide a promising therapeutic target for CSCC." 1 Circ_0104700 contributes to acute myeloid leukemia progression by enhancing MCM2 expression through targeting miR-665. hsa_circ_0104700 hsa_circ_HOMER2 circ_0104700 DOID:9119 acute myeloid leukemia acute myeloid leukemia RT-qPCR up-regulated circ_0104700 contributed to AML progression by enhancing MCM2 expression by targeting miR-665. 1 CircSLCO3A1 depletion ameliorates lipopolysaccharide-induced inflammation and apoptosis of human pulmonary alveolar epithelial cells through the miR-424-5p/HMGB3 pathway. hsa_circ_0003252 hsa_circ_SLCO3A1 circSLCO3A1 DOID:850 lung disease acute lung injury RT-qPCR up-regulated CircSLCO3A1 absence assuaged LPS-induced HPAEpiC inflammation and apoptosis through the miR-424-5p/HMGB3 axis. 1 Circular RNA circBNC2 facilitates glycolysis and stemness of hepatocellular carcinoma through the miR-217/high mobility group AT-hook 2 (HMGA2) axis. hsa_circ_0008732 hsa_circ_BNC2 circBNC2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Thus, the current data confirmed that circBNC2 sponged miR-217 to upregulate the HMGA2 level, thereby contributing to the HCC glycolysis and progression." 1 Hsa_circ_0003220 Drives Chemoresistance of Human NSCLC Cells by Modulating miR-489-3p/IGF1. hsa_circ_0003220 hsa_circ_TMCO7 circ_0003220 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "By controlling the miR-489-3p/IGF1 axis, hsa_circ_0003220 knockdown helped NSCLC overcome chemoresistance, suggesting a potential circRNA-targeted therapy for the disease." 1 Mutant KRAS mediates circARFGEF2 biogenesis to promote lymphatic metastasis of pancreatic ductal adenocarcinoma. hsa_circ_0060665 hsa_circ_ARFGEF2 circARFGEF2 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma "RT-qPCR, RNA-seq" up-regulated "CircARFGEF2 sponged miR-1205 and promoted the activation of JAK2, which phosphorylated STAT3 to trigger KRASG12D PDAC lymphangiogenesis and LN metastasis." 1 Circular RNA circ_KIAA1429 accelerates hepatocellular carcinoma progression via the miR-133a-3p/high mobility group AT-hook 2 (HMGA2) axis in an m6A-dependent manner. hsa_circ_0084922 hsa_circ_KIAA1429 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "To summarize, our study firstly investigated the involvement of a novel METTL3/m6A/circ_KIAA1429/miR-133a-3p/HMGA2 axis in regulating HCC development, which provided novel indicators for HCC diagnosis, therapy and prognosis." 2 Circ_103128 is associated with the tumorigenesis of medulloblastoma. hsa_circ_0061694 hsa_circ_DYRK1A circ_103128 DOID:0050902 medulloblastoma medulloblastoma "RT-qPCR, microarray" up-regulated "This study is the first to systematically demonstrate that circRNA_103128 may play an important regulatory role in MB through a sponge effect with miR-129 -5p, which affects SOX4 expression and regulates tumorigenesis and tumor cell development in MB." 1 CircUTRN24/miR-483-3p/IGF-1 Regulates Autophagy Mediated Liver Fibrosis in Biliary Atresia. hsa_circ_0009096 hsa_circ_UTRN circUTRN24 DOID:409 liver disease liver fibrosis RT-qPCR up-regulated These findings imply that circUTRN24/miR-483-3p/IGF-1 axis mediated LX-2 cell fibrosis by regulating autophagy. 1 METTL3-Modulated circUHRF2 Promotes Colorectal Cancer Stemness and Metastasis through Increasing DDX27 mRNA Stability by Recruiting IGF2BP1. hsa_circ_0002359 hsa_circ_UHRF2 circUHRF2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Taken together, METTL3-mediated m6A modification upregulated circUHRF2 and subsequently inhibited loss of DDX27 protein via recruitment of IGF2BP1, which conferred CRC stemness and metastasis." 1 Circ_PIAS1 Promotes the Apoptosis of ALV-J Infected DF1 Cells by Up-Regulating miR-183. - hsa_circ_PIAS1 Circ_PIAS1 DOID:4492 avian influenza ALV-J infection RT-qPCR down-regulated circ_PIAS1 up-regulated the expression of miR-183 and influenced ALV-J infection by promoting cell apoptosis. 1 Matrine suppresses liver cancer progression and the Warburg effect by regulating the circROBO1/miR-130a-5p/ROBO1 axis. hsa_circ_0066568 hsa_circ_ROBO1 circROBO1 DOID:3571 liver cancer liver cancer RT-qPCR up-regulated "Matrine impeded liver cancer development by mediating the circROBO1/miR-130a-5p/ROBO1 axis, which provided a theoretical basis for the application of matrine as an effective anticancer drug for liver cancer." 1 The role and mechanism of circ-BNC2 on the malignant progression of oral squamous cell carcinoma. hsa_circ_0086414 hsa_circ_BNC2 circ-BNC2 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated "Circ-BNC2 suppressed OSCC malignant progression by upregulating GNAS expression in a miR-142-3p-dependent manner, which suggested that circ-BNC2 might be a novel target for OSCC therapy." 2 Circ_0011373 promotes papillary thyroid carcinoma progression by regulating miR-1271/LRP6 axis. hsa_circ_0011373 hsa_circ_EIF3I circ_0011373 DOID:3969 thyroid gland papillary carcinoma papillary thyroid cancer RT-qPCR up-regulated "Circ_0011373 might be able to regulate PTC cell cycle, migration, invasion, and apoptosis by regulating the miR-1271/LRP6 axis." 1 Comprehensive analysis reveals the involvement of hsa_circ_0037858/miR-5000-3p/FMR1 axis in malignant metastasis of clear cell renal cell carcinoma. hsa_circ_0037858 hsa_circ_LITAF circ_0037858 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma "RT-qPCR, microarray" up-regulated "Collectively, we elucidated a potential hsa_circ_0037858/miR-5000-3p/FMR1 axis involved in ccRCC metastasis." 1 ALKBH5/YTHDF2-mediated m6A modification of circAFF2 enhances radiosensitivity of colorectal cancer by inhibiting Cullin neddylation. hsa_circ_0001947 hsa_circ_AFF2 circAFF2 DOID:9256 colorectal cancer colorectal cancer RT-qPCR down-regulated We identified and characterised circAFF2 as a novel m6A-modified circRNA and validated the ALKBH5/YTHDF2/circAFF2/Cullin-NEDD8 axis as a potential radiotherapy target for CRC. 1 Circ_0035292 knockdown alleviates lipopolysaccharide (LPS)-induced WI-38 cell apoptosis and inflammatory injury. hsa_circ_0035292 - circ_0035292 DOID:552 pneumonia pneumonia RT-qPCR up-regulated Knockdown of circ_0035292 rescued LPS-triggered WI-38 cell injury via miR-370-3p/TBL1XR1 axis and NF-¦ĘB pathway. 3 Exosome-delivered circRPS5 inhibits the progression of melanoma via regulating the miR-151a/NPTX1 axis. hsa_circ_0052351 hsa_circ_RPS5 circRPS5 DOID:1909 melanoma melanoma "RT-qPCR, RNA-seq" down-regulated "This finding reveal circRPS5 suppressed the progression of melanoma through miR-151a/NPTX1 pathway, and may provide a promising therapeutic strategies for melanoma." 1 Knockdown of circADAM9 inhibits cell progression and glycolysis by targeting the miR-1236-3p/FGF7 axis in breast cancer. hsa_circ_0001791 hsa_circ_ADAM9 circADAM9 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "CircADAM9 promoted BC development partly by the miR-1236-3p/FGF7 axis, highlighting a potential prognostic biomarker and therapeutic target for BC patients." 3 Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression. hsa_circ_0014188 hsa_circ_SNX27 circ-SNX27 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated This research demonstrated that circ-SNX27 accelerated the progression of HCC by modulating the miR-375/RPN1 axis. This is indicative of circ-SNX27s potential as a target for the treatment of HCC. 3 M2 macrophage-derived extracellular vesicles augment immune evasion and development of colorectal cancer via a circRNA_CCDC66/microRNA-342-3p/metadherin axis. - hsa_circ_CCDC66 circRNA_CCDC66 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "In summary, this study reveals that the M2-EVs augment immune evasion and development of CRC by delivering circ_CCDC66 and restoring the MTDH level." 4 Plasma exosomal hsa_circ_0079439 as a novel biomarker for early detection of gastric cancer. hsa_circ_0079439 hsa_circ_PHF14 circ_0079439 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "Therefore, plasma exosomal hsa_circ_0079439 might be a potential biomarker for the diagnosis of GC during both the early and late stages." 2 CircNCOR1 regulates breast cancer radiotherapy efficacy by regulating CDK2 via hsa-miR-638 binding. hsa_circ_0042174 hsa_circ_NCOR1 circNCOR1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Our results demonstrated that circNCOR1 bounds to hsa-miR-638 and targets CDK2, thereby regulating the radiosensitivity of TNBC." 1 Hsa_circ_0003596 enhances the development of cell renal clear cell carcinoma through the miR-502-5p/IGF1/PI3K/AKT axis. hsa_circ_0003596 hsa_circ_COL5A1 circ_0003596 DOID:4467 clear cell renal cell carcinoma clear cell renal cell carcinoma RT-qPCR up-regulated "Overall, the results of the present study showed that hsa_circ_0003596 facilitated the proliferation, infiltration and migration of ccRCC through the miR-502-5p/IGF1R/PI3K/AKT axis." 1 Downregulation of circular RNA hsa_circ_0087856 sensitizes bladder cancer cells to cisplatin through targeting miR-1184/CITED2 signaling. hsa_circ_0087856 hsa_circ_RAD23B - DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Overall, our results revealed the role of hsa_circ_0087856 that downregulation its expression could enhance the BC cells sensitivity to cisplatin by facilitating CITED expression via sponging miR-1184." 1 CircDUS2L (circ_0039908) promotes lung adenocarcinoma progression by upregulating PGAM1 by acting as a miR-590-5p molecular sponge. hsa_circ_0039908 hsa_circ_DUS2L circDUS2L DOID:3910 lung adenocarcinoma lung adenocarcinoma "RT-qPCR, microarray" up-regulated "CircDUS2L elevated PGAM1 expression through functioning as a miR-590-5p sponge, thus driving malignant behaviors and glycolysis of LUAD cells." 2 "CircTBX5 knockdown modulates the miR-558/MyD88 axis to alleviate IL-1beta-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the NF-kappaB signaling." - hsa_circ_TBX5 circTBX5 DOID:8398 osteoarthritis osteoarthritis RT-qPCR up-regulated "CircTBX5 knockdown modulated the miR-558/MyD88 axis to alleviate IL-1beta induced chondrocyte apoptosis, ECM degradation and inflammation via inactivating the NF-§ÜB signaling pathway." 1 Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7. hsa_circ_0001451 hsa_circ_FBXW7 circ-FBXW7 DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated "Our bench study, in vivo experiments, and clinical validation have unequivocally shown that circFBXW7 effectively inhibits the abilities of LUAD stem cells and reverses resistance to TKIs by modulating Wnt pathway functions through the action of circFBXW7-185AA on beta-catenin ubiquitination and inhibition." 1 Hsa_circ_0102899 promotes epithelial-mesenchymal transition in non-small cell lung cancer. hsa_circ_0102899 hsa_circ_TC2N circ_0102899 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated circ_0102899 promotes EMT and metastasis in NSCLC by regulating the miR-885-5p/EIF4G2 axis. 1 Circ_0005615 promotes cervical cancer cell growth and metastasis by modulating the miR-138-5p/KDM2A axis. hsa_circ_0005615 hsa_circ_NFATC3 circ_0005615 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated Circ_0005615 acted as a tumor promoter in CC by regulating the miR-138-5p/KDM2A pathway. 2 Exosome-derived circKIF20B suppresses gefitinib resistance and cell proliferation in non-small cell lung cancer. hsa_circ_0019079 hsa_circ_KIF20B circKIF20B DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR down-regulated This study revealed a novel mechanism of circKIF20B/miR-615-3p/MEF2A signaling axis involving progression of gefitinib resistance in NSCLC. 1 Gene SH3BGRL3 regulates acute myeloid leukemia progression through circRNA_0010984 based on competitive endogenous RNA mechanism. hsa_circ_0010984 hsa_circ_SH3BGRL3 "circRNA_0010984, circSH3BGRL3" DOID:9119 acute myeloid leukemia acute myeloid leukemia "RT-qPCR, RNA-seq, microarray" up-regulated circRNA_0010984 was significantly up-regulated in AML and promoted cell proliferation by regulating miR-375 through molecular sponge action. 1 Hsa_circ_0084003 modulates glycolysis and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma through targeting hsa-miR-143-3p/DNMT3A axis. hsa_circ_0084003 hsa_circ_FGFR1 circ_0084003 DOID:3498 pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma RT-qPCR up-regulated "Therefore, hsa_circ_0084003 could be studied as a possible therapeutic target regarding pancreatic ductal adenocarcinoma." 1 circNFATC3 facilitated the progression of oral squamous cell carcinoma via the miR-520h/LDHA axis. hsa_circ_0005615 hsa_circ_NFATC3 circNFATC3 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR up-regulated "In conclusion, circNFATC3 promoted the advancement of OSCC by adjusting the miR-520h/LDHA axis." 1 Upregulation of hsa_circ_0002003 promotes hepatocellular carcinoma progression hsa_circ_0002003 hsa_circ_KIAA0146 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated Hsa_circ_0002003 may play critical roles in HCC pathogenesis and serve as a potential prognostic biomarker for HCC. Targeting the hsa_circ_0002003/hsa-miR-1343-3p/STMN1 regulatory axis could be an effective therapeutic strategy in patients with HCC. 1 Upregulation of hsa_circ_0002003 promotes hepatocellular carcinoma progression hsa_circ_0002454 hsa_circ_DNAJC6 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma microarray up-regulated "Three significantly upregulated circRNAs, hsa_circ_0002003, hsa_circ_0002454, and hsa_circ_0001394, and one significantly downregulated circRNA, hsa_circ_0003239, were identified and validated by qRT-PCR." 1 Upregulation of hsa_circ_0002003 promotes hepatocellular carcinoma progression hsa_circ_0001394 hsa_circ_TBC1D14 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" up-regulated "Three significantly upregulated circRNAs, hsa_circ_0002003, hsa_circ_0002454, and hsa_circ_0001394, and one significantly downregulated circRNA, hsa_circ_0003239, were identified and validated by qRT-PCR." 2 Upregulation of hsa_circ_0002003 promotes hepatocellular carcinoma progression hsa_circ_0003239 hsa_circ_UBE2G1 - DOID:684 hepatocellular carcinoma hepatocellular carcinoma "RT-qPCR, microarray" down-regulated "Three significantly upregulated circRNAs, hsa_circ_0002003, hsa_circ_0002454, and hsa_circ_0001394, and one significantly downregulated circRNA, hsa_circ_0003239, were identified and validated by qRT-PCR." 1 Downregulation of circ-Foxo3 in breast cancer stem-like cells - hsa_circ_FOXO3 circ-Foxo3 DOID:1612 breast cancer breast cancer RT-qPCR down-regulated "Circ-Foxo3 expression was significantly downregulated in spheroid-forming tumor cells, according to our data. This study demonstrated that breast CSCs have downregulated circ-Foxo3 expression, which may allow these cells to evade apoptosis." 3 CircGNB1 facilitates the malignant phenotype of GSCs by regulating miR-515-5p/miR-582-3p-XPR1 axis hsa_circ_0009362 hsa_circ_GNB1 circGNB1 DOID:0060108 brain glioma brain glioma "RT-qPCR, microarray" up-regulated "Our study reveals that circGNB1 plays a crucial role in promoting tumorigenesis and malignant progression in glioma, which provides a promising cancer biomarker." 1 A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer - hsa_circ_CAPG circCAPG DOID:60081 triple-receptor negative breast cancer triple-negative breast cancer "RT-qPCR, RNA-seq" up-regulated circCAPG significantly enhances the proliferation and metastasis of TNBC cells by encoding a novel polypeptide CAPG-171aa and afterwards activates MEKK2-MEK1/2-ERK1/2 pathway. 1 Circular RNA circ-FIRRE interacts with HNRNPC to promote esophageal squamous cell carcinoma progression by stabilizing GLI2 mRNA hsa_circ_0001944 hsa_circ_FIRRE circ-FIRRE DOID:3748 esophagus squamous cell carcinoma esophageal squamous cell carcinoma "RT-qPCR, RNA-seq" up-regulated "In summary, our results indicate that circ-FIRRE could serve as a valuable biomarker and potential therapeutic target for ESCC and highlight a novel mechanism of the circ-FIRRE/HNRNPC complex in ESCC progression regulation." 1 CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non-small-cell lung cancer via miR-590-5p/SOX5 axis hsa_circ_0001387 hsa_circ_WHSC1 CircWHSC1 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "CircWHSC1 may contribute to the oncogenicity of NSCLC via the regulation of miR-590-5p/SOX5 axis, which might be a novel therapeutic target in NSCLC." 3 hucMSCs treatment ameliorated pulmonary fibrosis via downregulating the circFOXP1-HuR-EZH2/STAT1/FOXK1 autophagic axis. - hsa_circ_FOXP1 circFOXP1 DOID:3770 pulmonary fibrosis pulmonary fibrosis RT-qPCR up-regulated "In conclusion, hucMSCs treatment significantly improved pulmonary fibrosis by downregulating the circFOXP1-HuR-EZH2/STAT1/FOXK1 autophagic axis. hucMSCs can act as an effective treatment for pulmonary fibrosis." 1 Circular RNA PGPEP1 induces colorectal cancer malignancy and immune escape hsa_circ_0050102 hsa_circ_PGPEP1 circPGPEP1 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Collectively, circPGPEP1 exerts an oncogene role in CRC by regulating the miR-515-5p/NFAT5 axis." 1 circSnd1 promotes atherosclerosis progression through the miR-485-3p/Olr1 signaling pathway. - hsa_circ_Snd1 circSnd1 DOID:10230 aortic atherosclerosis atherosclerosis RT-qPCR up-regulated The circSnd1/miR-485-3p/Olr1 axis participates in the formation and development of atherosclerosis by regulating inflammation and lipid transport. 1 Circ_0001589/miR-1248/HMGB1 axis enhances EMT-mediated metastasis and cisplatin resistance in cervical cancer hsa_circ_0001589 hsa_circ_HIST1H1D circ_0001589 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In summary, our findings suggest the upregulation of circ_0001589 promoted EMT-mediated cell migration and invasion, and enhanced cisplatin resistance via regulating miR-1248/HMGB1 axis in cervical cancer." 1 CircSFMBT2-OA alleviates chondrocyte apoptosis and extracellular matrix degradation through repressing NF-kappaB/NLRP3 inflammasome activation. hsa_circ_0017636 hsa_circ_SFMBT2 circSFMBT2-OA DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated These data reveal a vital effect of a novel circSFMBT2-OA on repressing OA progression and provide a promising target to treat OA. 1 Significant role of circRNA BBS9 in chronic obstructive pulmonary disease via miRNA-103a-3p/BCL2L13 - hsa_circ_BBS9 - DOID:3083 chronic obstructive pulmonary disease chronic obstructive pulmonary disease RT-qPCR up-regulated circRNA BBS9 is involved in COPD development as it inhibits the functioning of miRNA-103a-3p. Our results suggest that circRNA BBS9 may act as a novel target for treating COPD. 1 circRPS19 affects HK2_mediated aerobic glycolysis and cell viability via the miR_125a_5p/USP7 pathway in gastric cancer - hsa_circ_RPS19 circRPS19 DOID:10534 stomach cancer gastric cancer "RT-qPCR, microarray" up-regulated "Taken together, circRPS19 induced aerobic glycolysis of GC cells by stabilizing HK2 protein via the miR_125a_5p/USP7 axis and thus promoting the progression of GC." 1 Mechanism of tumor-derived extracellular vesicles in prostatic cancer progression through the circFMN2/KLF2/RNF128 axis hsa_circ_0005100 hsa_circ_FMN2 circFMN2 DOID:10283 prostate cancer prostate cancer RT-qPCR up-regulated CircFMN2 is upregulated in PC tissues and cells and correlated with clinical features of PC patients 2 A novel CircRNA Circ_0001722 regulates proliferation and invasion of osteosarcoma cells through targeting miR-204-5p/RUNX2 axis hsa_circ_0001722 hsa_circ_CDK14 - DOID:3347 osteosarcoma osteosarcoma "RT-qPCR, microarray" up-regulated "Circ_001722 is a novel tumor promotor in OS, and promotes the progression of OS via miR-204-5p/RUNX2 axis." 5 Circular RNA circ_0000376 promotes paclitaxel resistance and tumorigenesis of non-small cell lung cancer via positively modulating KPNA4 by sponging miR-1298-5p hsa_circ_0000376 hsa_circ_PRH1-PRR4 circ_0000376 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0000376 facilitated PTX resistance and tumorigenesis of NSCLC by miR-1298-5p/KPNA4 axis, suggesting an underlying therapeutic strategy for NSCLC." 4 Protective effects of hsa_circ_0072568 on interleukin_1beta__timulated human chondrocytes are mediated via the miR_382_5p/TOP1 axis. hsa_circ_0072568 - Circ0072568 DOID:8398 osteoarthritis osteoarthritis RT-qPCR down-regulated "On the whole, the present study demonstrates that the Circ0072568/miR-382-5p/TOP1 axis is involved in inflammation and ECM degradation in OA. These findings may contribute to the development of potential therapeutic strategies for OA." 2 A Novel Circ_Arf3/miR-452-5p/Mbnl1 Axis Regulates Proliferation and Expression of Fibrosis-Related Proteins of Mouse Mesangial Cells Under High Glucose mmu_circ_0000650 mmu_circ_Arf3 circ_0000650 DOID:557 kidney disease diabetic nephropathy RT-qPCR down-regulated Overexpression of circ_Arf3 prevents cell proliferation and fibrous formation in HG-treated MCs by regulating the expression of Mbnl1 via miR-452-5p. 1 Cytoskeleton remodeling mediated by circRNA-YBX1 phase separation suppresses the metastasis of liver cancer hsa_circ_0006302 hsa_circ_ASH2 circASH2 DOID:3571 liver cancer liver cancer "RT-qPCR, microarray" down-regulated "Together, our data have revealed a tumor-suppressive circRNA and, more importantly, uncovered a fine regulation mechanism for HCC progression." 1 Energy stress-induced circZFR enhances oxidative phosphorylation in lung adenocarcinoma via regulating alternative splicing hsa_circ_0072088 hsa_circ_ZFR CircZFR DOID:3910 lung adenocarcinoma lung adenocarcinoma RT-qPCR up-regulated Our study provides new insights into the role of circRNAs in anticancer metabolic therapies and expands our understanding of alternative splicing. 2 "Circular RNA circADAM9 Promotes Inflammation, Oxidative Stress, and Fibrosis of Human Mesangial Cells via the Keap1-Nrf2 Pathway in Diabetic Nephropathy." - hsa_circ_ADAM circADAM DOID:9743 diabetic neuropathy diabetic nephropathy RT-qPCR up-regulated the circADAM9/miR-545-3p/USP15/Keap1/Nrf2 signaling axis is critical for HG-induced cell injury in HMCs and might represent a novel therapeutic target for DN treatment. 1 circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis - hsa_circ_THBS1 - DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "In conclusion, circRNA THBS1 silencing inhibited the malignant biological behaviors of cervical cancer cells via the regulation of miR-543/HMGB2 axis." 1 hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt/beta-catenin signaling pathway hsa_circ_0000285 hsa_circ_HIPK3 circ_0000285 DOID:769 neuroblastoma neuroblastoma RT-qPCR up-regulated "Circ_0000285 functions as an miR-582-3p sponge to strengthen Wnt/beta-catenin signaling activity, thus exacerbating NB development." 1 Circular RNA nuclear receptor interacting protein 1 promoted biliary tract cancer epithelial-mesenchymal transition and stemness by regulating the miR-515-5p/AKT2 axis and PI3K/AKT/mTOR signaling pathway hsa_circ_0004771 hsa_circ_NRIP1 - DOID:4607 biliary tract cancer biliary tract cancer RT-qPCR up-regulated "Generally, targeting the circ_NRIP1/miR-515-5p/AKT2 axis and aberrant activation of the PI3K/AKT/mTOR pathway may hold promising therapeutic strategies for BTC." 1 "circRNF13, a novel N6-methyladenosine-modified circular RNA, enhances radioresistance in cervical cancer by increasing CXCL1 mRNA stability" hsa_circ_0001346 hsa_circ_RNF13 circRNF13 DOID:4362 cervical cancer cervical cancer RT-qPCR down-regulated This study identified circRNF13 as a novel m6A-modified circRNA and validated the METTL3/YTHDF2/circRNF13/CXCL1 axis as a potential target for CC radiotherapy. 1 Expression of circ-PHC3 enhances ovarian cancer progression via regulation of the miR-497-5p/SOX9 pathway hsa_circ_0005228 hsa_circ_PHC3 circ-PHC3 DOID:2394 ovarian cancer ovarian cancer RT-qPCR up-regulated "Taken together, our findings suggest that circ-PHC3 enhances OC progression through functioning as an miR-497-5p sponge to promote SOX9 expression, supporting its potential as a promising candidate target for OC therapy." 1 Exosomal circTGFBR2 promotes hepatocellular carcinoma progression via enhancing ATG5 mediated protective autophagy hsa_circ_0005224 hsa_circ_TGFBR2 circTGFBR2 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR up-regulated "Thus, we revealed that circTGFBR2 is a novel tumor promoter circRNA in hepatocytic exosomes and promotes HCC progression by enhancing ATG5-mediated protective autophagy via the circTGFBR2/miR-205-5p/ATG5 axis, which may be a potential therapeutic target for HCC." 1 circSLC4A7 accelerates stemness and progression of gastric cancer by interacting with HSP90 to activate NOTCH1 signaling pathway - hsa_circ_SLC4A7 circSLC4A7 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated This study highlights a novel oncogenic function of circSLC4A7 mediated by its binding with HSP90 and thus activating the Notch1 signaling pathway. 1 Identification of autophagy-associated circRNAs in sepsis-induced cardiomyopathy of mice. - - circRNA_27393 DOID:0040085 bacterial sepsis sepsis-induced cardiomyopathy "RT-qPCR, microarray" down-regulated These findings provide insights into circRNAs and identified new research targets that may be used to further explore the pathogenesis of SICM. 1 Identification of autophagy-associated circRNAs in sepsis-induced cardiomyopathy of mice. - - circRNA_22171 DOID:0040085 bacterial sepsis sepsis-induced cardiomyopathy "RT-qPCR, microarray" up-regulated These findings provide insights into circRNAs and identified new research targets that may be used to further explore the pathogenesis of SICM. 1 Extracellular vesicle-circEHD2 promotes the progression of renal cell carcinoma by activating cancer-associated fibroblasts hsa_circ_0003146 hsa_circ_EHD2 circEHD2 DOID:4467 clear cell renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated The circEHD2/YWHAH/YAP/SOX9 signaling pathway accelerates the growth of RCC. 2 Circ_PRDM5/miR-25-3p/ANKRD46 axis is associated with cell malignant behaviors in subjects with breast cancer evaluated by ultrasound hsa_circ_0005654 hsa_circ_PRDM5 - DOID:1612 breast cancer breast cancer RT-qPCR down-regulated This study evidenced that circ_PRDM5 inhibited cell progression and tumor growth in BC via interacting with mir-25-3p/ANKRD46 network. 1 Circ-NFKB1 sponges miR-203a-5p to regulate ERBB4 expression and promotes IL-1beta induced chondrocytes apoptosis. - hsa_circ_NFKB1 circ-NFKB1 DOID:8398 osteoarthritis Osteoarthritis RNA-Seq up-regulated Silencing circ-NFKB1 could sponge miR-203a-5p to regulate ERBB4 expression and alleviate OA progression. 2 Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis. - hsa_circ_Shank3 circ-Shank3 DOID:1561 cognitive disorder postoperative cognitive dysfunction RT-qPCR up-regulated "Collectively, our results found that Dex could attenuate the neuroinflammation and microglia activation in BV2 cells exposed to LPS via targeting circ-Shank3/miR-140-3p/TLR4 axis." 1 Sinomenine regulates circTRPM7-related pathway to inhibit gastric cancer cell growth and metastasis hsa_circ_0004951 hsa_circ_TRPM7 circTRPM7 DOID:10534 stomach cancer gastric cancer RT-qPCR up-regulated "To sum up, our data indicated that Sinomenine played an antitumor role in gastric cancer cells via circTRPM7/miR-145-5p/PBX3 axis." 1 Cancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication hsa_circ_0077892 hsa_circ_TBPL1 circTBPL1 DOID:1612 breast cancer breast cancer RT-qPCR up-regulated "Taken together, these results revealed that exosomal circTBPL1 derived from CAFs contributed to cancer progression via miR-653-5p/TPBG pathway, indicating the potential of exosomal circTBPL1 as a biomarker and novel therapeutic target for breast cancer." 1 Hsa_circ_0057105 modulates a balance of epithelial-mesenchymal transition and ferroptosis vulnerability in renal cell carcinoma hsa_circ_0057105 hsa_circ_PDK1 - DOID:4467 clear cell renal cell carcinoma renal cell carcinoma RT-qPCR up-regulated "In RCC, hsa_circ_0057105 regulates COL1A1 and VDAC2 expression through its sponge effect on miR_577, acting like a ˇ®double_edged swordˇŻ." 1 CircSLC39A8 attenuates paclitaxel resistance in ovarian cancer by regulating the miR_185_5p/BMF axis hsa_circ_0002782 hsa_circ_SLC39A8 CircSLC39A8 DOID:2394 ovarian cancer ovarian cancer "RT-qPCR, RNA-seq" down-regulated Our findings demonstrate that circSLC39A8 can promote PTX sensitivity by regulating the miR-185_5p/BMF axis. 1 Downregulation of circ_0035292 Alleviates LPS-Induced WI-38 Cell Injury via Targeting miR-494-3p/TLR4 Pathway in Infantile Pneumonia. hsa_circ_0035292 - circ_0035292 DOID:552 pneumonia pneumonia RT-qPCR up-regulated "Circ_0035292 might be a potential target for infantile pneumonia treatment, which knockdown could relieve LPS-induced cell injury via the regulation of miR-494-3p/TLR4 axis." 3 Hsa_circ_0000073 promotes lipid synthesis of osteosarcoma through hsa-miR-1184/ FADS2 pathway hsa_circ_0000073 hsa_circ_OMA1 - DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated "Our study revealed that hsa_circ_0000073 contributed to the lipid synthesis of osteosarcoma by decreasing the expression of miR-1184, thereby increasing FADS2, which provides new insights into treating osteosarcoma." 4 CircAFF1 Is a Circular RNA with a Role in Alveolar Rhabdomyosarcoma Cell Migration hsa_circ_0001423 hsa_circ_AFF1 circAFF1 DOID:3247 rhabdomyosarcoma alveolar rhabdomyosarcoma RT-qPCR up-regulated "Using RH4 and RH30 cell lines, a classical cell line models for alveolar rhabdomyosarcoma, we demonstrated that circAFF1 is a cytoplasmatic circRNA and its depletion impacts cell homeostasis favouring cell migration through the downregulation of genes involved in cell adhesion pathways" 1 CircRIMS promotes cerebral ischemia-reperfusion injury through increasing apoptosis and targeting the miR-96-5p/JAK/STAT1 axis. - hsa_circ_RIMS CircRIMS DOID:326 ischemia cerebral ischemia-reperfusion injury RT-qPCR up-regulated CircRIMS contributes to the progression of CIR injury via regulating miR-96-5p/JAK/STAT1 axis. 1 "Circ_0090231 knockdown protects vascular smooth muscle cells from ox-LDL-induced proliferation, migration and invasion via miR-942-5p/PPM1B axis during atherosclerosis" hsa_circ_0090231 hsa_circ_USP9X circ_0090231 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "Silencing of circ_0090231 could reverse ox-LDL-induced proliferation, migration and invasion in VSMCs via miR-942-5p/PPM1B axis, providing a theoretical basis for elucidating the mechanism of AS process." 2 Bioinformatics and Experimental Identification of circ_0001535 Associated with Diagnosis and Development of Alzheimer Disease hsa_circ_0001535 hsa_circ_FAM13B circ_0001535 DOID:10652 Alzheimer disease Alzheimer disease "RT-qPCR, RNA-seq" up-regulated Our research in AD circRNA can offer important information regarding the role of specific circRNAs in the AD environment and point to specific future areas of therapeutic intervention in AD 1 circRNA-SFMBT2 orchestrates ERalpha activation to drive tamoxifen resistance in breast cancer cells hsa_circ_0017639 hsa_circ_SFMBT2 circRNA-SFMBT2 DOID:1612 breast cancer breast cancer "RT-qPCR, microarray" up-regulated "In summary, circRNA-SFMBT2 is an important regulator of ERalpha signaling, and antagonizing circRNA-SFMBT2 expression may constitute a potential therapeutic strategy for breast cancer." 1 Circ_0001714 knockdown alleviates lipopolysaccharide-induced apoptosis and inflammation in renal tubular epithelial cells via miR-129-5p/TRAF6 axis in septic acute kidney injury. hsa_circ_0001714 - Circ_0001714 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated Circ_0001714 silencing might alleviate LPS-induced apoptosis and inflammation via targeting miR-129-5p/TRAF6 axis in HK-2 cells. 1 ZEB1-mediated biogenesis of circNIPBL sustains the metastasis of bladder cancer via Wnt/beta-catenin pathway hsa_circ_0001472 hsa_circ_NIPBL circNIPBL DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "Our study highlights that circNIPBL-induced Wnt signaling pathway activation triggers ZEB1-mediated circNIPBL biogenesis, which forms a positive feedback loop via the circNIPBL/miR-16-2-3p/Wnt5a/ZEB1 axis, supporting circNIPBL as a novel therapeutic target and potential biomarker for BCa patients." 1 Circ_0000235 targets MCT4 to promote glycolysis and progression of bladder cancer by sponging miR-330-5p hsa_circ_0000235 hsa_circ_CCNY "Circ_0000235, circ235" DOID:11054 urinary bladder cancer bladder cancer RT-qPCR up-regulated "In conclusion, these findings suggest that circ235 may be a viable molecular marker and therapeutic target for Bca." 1 Circular RNA 0000157 depletion protects human bronchial epithelioid cells from cigarette smoke extract-induced human bronchial epithelioid cell injury through the microRNA-149-5p/bromodomain containing 4 pathway. hsa_circ_0000157 - circ_0000157 DOID:3083 chronic obstructive pulmonary disease COPD RT-qPCR up-regulated "Circ_0000157 knockdown ameliorated CSE-caused 16HBE cell damage by targeting the miR-149-5p/BRD4 pathway, providing a potential therapeutic strategy for clinic intervention in COPD." 1 Circular RNA circSLC7A11 contributes to progression and stemness of laryngeal squamous cell carcinoma via sponging miR-877-5p from LASP1 hsa_circ_0070975 hsa_circ_SLC7A11 circSLC7A11 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma RT-qPCR up-regulated "CircSLC7A11 exerted oncogenic functions in LSCC by miR-877-5p/LASP1, hinting that circSLC7A11 was a novel biomarker for LSCC." 1 hsa_circ_0010889 downregulation inhibits malignant glioma progression by modulating the miR-590-5p/SATB1 axis hsa_circ_0010889 hsa_circ_PITHD1 - DOID:0060108 brain glioma brain glioma "RT-qPCR, RNA-seq" up-regulated "Taken together, our study demonstrates that hsa_circ_0010889 downregulation inhibits glioma progression through the miR-590-5p/SATB1 axis." 1 Circular RNA circ_0000119 promotes cervical cancer cell growth and migration via miR-433-3p/PAK2 axis hsa_circ_0000119 hsa_circ_MAN1A2 circ_0000119 DOID:4362 cervical cancer cervical cancer RT-qPCR up-regulated "Circ_0000119 was upregulated in CC, and circ_0000119 knockdown suppressed CC malignant development through the miR-433-3p/PAK2 axis." 2 P53-response circRNA_0006420 aggravates lung cancer radiotherapy resistance by promoting formation of HUR/PTBP1 complex - hsa_circ_AEBP2 circRNA_0006420 DOID:1324 lung cancer lung cancer "RT-qPCR, RNA-seq" up-regulated Lung cancer cells retaining p53 may upregulate circRNA_0006420 (IRSense) expression post radiation to form an IRSense/HUR/PTBP1 complex leading to radiotherapy resistance 1 Circ_0001806 relieves LPS-induced HK2 cell injury by regulating the expression of miR-942-5p and TXNIP. hsa_circ_0001806 - circ_0001806 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated "circ_0001806 knockdown could reduce LPS-induced HK2 cell injury by regulating TXNIP expression via targeting miR-942-5p, indicating that circ_0001806 might be an important biomarker for alleviating sepsis-related AKI." 1 CircCDK1 blocking IGF2BP2-mediated m6A modification of CPPED1 promotes laryngeal squamous cell carcinoma metastasis via the PI3K/AKT signal pathway hsa_circ_0005774 hsa_circ_CDK1 CircCDK1 DOID:2876 laryngeal squamous cell carcinoma laryngeal squamous cell carcinoma "RT-qPCR, microarray" up-regulated Our findings demonstrated that EIF4A3-induced upregulation of circCDK1 promoted LSCC metastasis via EIF4A3-circCDK1-IGF2BP2-CPPED1 to activate PI3K-AKT signal pathway. 1 "Circ_0006324 regulates cell proliferation, cell-cycle progression, apoptosis, and glycolysis of non-small cell lung cancer cells through miR-496/TRIM59 axis" hsa_circ_0006324 hsa_circ_DENND1B Circ_0006324 DOID:3908 lung non-small cell carcinoma non-small cell lung cancer RT-qPCR up-regulated "Circ_0006324 functioned as a tumor promoter in NSCLC to promote cell proliferation, cell cycle progression, and glycolysis and inhibit cell apoptosis via miR-496/TRIM59 axis." 1 Circtdrd9 Contributes to Sepsis-Induced Acute Lung Injury by Enhancing the Expression of Rab10 Via Directly Binding to Mir-223-3p. - hsa_circ_TDRD9 circTDRD9 DOID:850 lung disease acute lung injury RT-qPCR up-regulated CircTDRD9 overexpression was closely associated with LPS-induced ALI. CircTDRD9 contributed to LPS-induced ALI partly by upregulating RAB10 via binding to miR-223-3p. 1 Circular RNA ANKIB1 alleviates hypoxia-induced cardiomyocyte injury by modulating miR-452-5p/SLC7A11 axis - hsa_circ_ANKIB1 circANKIB1 DOID:114 heart disease hypoxia-induced cardiomyocyte injury RT-qPCR down-regulated "This investigation revealed for the first time that circANKIB1 regulated signaling of the miR-452-5p/SLC7A11 axis, thereby ameliorating hypoxia-induced cardiomyocyte injury." 1 "Circ_0002131 contributes to LPS-induced apoptosis, inflammation and oxidative injury in HK-2 cells via inhibiting the binding between miR-942-5p and OXSR1." hsa_circ_0002131 - Circ_0002131 DOID:3021 acute kidney failure acute kidney injury RT-qPCR up-regulated "circ_0002131 promoted LPS-mediated HK-2 cell injury via miR-942-5p-mediated upregulation of OXSR1, suggesting that circ_0002131/miR-942-5p/OXSR1 axis was related to sepsis-induced AKI progression." 1 Nucleus-localized circSLC39A5 suppresses hepatocellular carcinoma development by binding to STAT1 to regulate TDG transcription hsa_circ_0026920 hsa_circ_SLC39A5 circSLC39A5 DOID:684 hepatocellular carcinoma hepatocellular carcinoma RT-qPCR down-regulated "Our findings uncovered a novel plasma circRNA, circSLC39A5, which may be a potential circulating diagnostic marker for HCC, and the mechanism by which nucleus-localized circSLC39A5 exerts a transcriptional regulatory role in HCC by affecting STAT1/TDG/PCNA provides new insights into the mechanism of circRNAs." 1 The circRNA MKLN1 regulates autophagy in the development of diabetic retinopathy. - hsa_circ_MKLN1 CircMKLN1 DOID:8947 diabetic retinopathy Diabetic retinopathy RT-qPCR up-regulated "CircMKLN1-silencing treatment reduces HG/MG-related reactive autophagy and inflammation. In addition, miR-26a-5p targeting by circMKLN1 plays an important role in the regulation of Rab11a expression. Thus, either new biomarkers or new therapeutic targets may be identified with the translation of these findings." 1 Hsa_circ_0000106 Acts as a Tumor Promoter in Pancreatic Cancer by Targeting the MiR-455-3p/HDAC4 hsa_circ_0000106 hsa_circ_CEPT1 - DOID:1793 pancreatic cancer pancreatic cancer RT-qPCR up-regulated "In conclusion, circ_0000106 promotes tumor migration and growth in PC by targeting the miR-455-3p/HDAC4 axis. These results suggest that the circ 0000106/miR-455-3p/HDAC4 network could be regarded as a latent target for PC treatment." 1 Knockdown of circEXOC6 inhibits cell progression and glycolysis by sponging miR-433-3p and mediating FZD6 in glioma hsa_circ_0019170 hsa_circ_EXOC6 circEXOC6 DOID:0060108 brain glioma glioma RT-qPCR up-regulated "Deletion of circEXOC6 restrained cell progression and glycolysis by sponging miR-433-3p and interacting with FZD6, which might provide an underlying target for glioma treatment." 1 CircEpha5 regulates the synthesis and secretion of androgen in mouse preantral follicles by targeting miR-758-5p. - mmu_circ_Epha5 CircEpha5 DOID:11612 polycystic ovary syndrome polycystic ovary syndrome "RT-qPCR, RNA-seq" up-regulated This work is contributed to the understanding of the pathogenesis of hyperandrogenemia and lays the foundation for the development of therapeutic targets of PCOS hyperandrogenism. 1 CircECE1 promotes osteosarcoma progression through regulating RAB3D by sponging miR-588 hsa_circ_0002402 hsa_circ_ECE1 CircECE1 DOID:3347 osteosarcoma osteosarcoma RT-qPCR up-regulated We elucidated the function of a novel circECE1/miR-588/RAB3D axis in OS progression. 2 Circ_0000370 Plays an Oncogenic Role in Colorectal Cancer by Regulating the miR-502-5p/SIRT1 Axis hsa_circ_0000370 hsa_circ_FLI1 circ_0000370 DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Circ_0000370 induced the proliferation and metastasis of CRC cells by sponging miR-502-5p and enhancing SIRT1 expression, which provided a possible target for CRC treatment." 2 MiR-485-3p/MiR-543/MiR-337-3p is Required for the Oncogenic Potential of the Hsa_circ_0007385-MEMO1 Axis in Colorectal Cancer hsa_circ_0007385 hsa_circ_MEMO1 - DOID:9256 colorectal cancer colorectal cancer RT-qPCR up-regulated "Hsa_circ_0007385 promoted CRC progression via modulating miR-485-3p/miR-543/miR-337-3p/MEMO1 axis. Thus, circ-MEMO1 might be a promising therapeutic target for CRC." 1 CircLDLRAD3 inhibits Oral squamous cell carcinoma progression by regulating miR-558/Smad4/TGF-beta - hsa_circ_LDLRAD3 CircLDLRAD3 DOID:50866 oral squamous cell carcinoma oral squamous cell carcinoma RT-qPCR down-regulated Our study found that circLDLRAD3 is downregulated in OSCC and verified its tumour suppressor function and mechanism in OSCC through sponging miR-558 to regulate miR-558/Smad4/TGF-beta axis. 1 Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner hsa_circ_0007379 hsa_circ_SNX6 "Circ_0007379, circ7379" DOID:9256 colorectal cancer colorectal cancer "RT-qPCR, RNA-seq" down-regulated "Thus, our findings establish a previously unrecognized function of circRNA in inhibiting CRC progression." 1 Hsa_circRNA_103124 upregulation in Crohn disease promoted macrophage M1 polarization to maintain an inflammatory microenvironment via activation of the AKT2 and TLR4/NF-¦ĘB pathways hsa_circ_0001187 hsa_circ_DOPEY2 Hsa_circRNA_103124 DOID:8778 Crohn disease Crohn disease RT-qPCR up-regulated Hsa_circRNA_103124 could serve as a potential biomarker and a novel therapeutic target in CD progression. 1 Circular RNA PARG adjusts miR-140-3p to influence progression in sepsis. - hsa_circ_PARG circRNA-PARG DOID:0040085 bacterial sepsis Sepsis RT-qPCR up-regulated a novel insight into understanding the important effects of circRNA PARG in sepsis is provided. 1 Circ_0003575 knockdown alleviates ox-LDL-induced human aortic endothelial cell dysfunction in atherosclerosis by miR-637/TRAF6 axis. hsa_circ_0003575 - Circ_0003575 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated Circ_0003575 knockdown alleviated ox-LDL-induced HAEC damage by regulating miR-637/TRAF6 and NF-¦ĘB pathways. 3 Exosomal circBBS2 inhibits ferroptosis by targeting miR-494 to activate SLC7A11 signaling in ischemic stroke. - hsa_circ_BBS2 circBBS2 DOID:3526 cerebral infarction ischemic stroke RT-qPCR down-regulated "UC-MSCs-derived exosomal circBBS2 enhanced SLC7A11 expression via sponging miR-494, therefore repressing ferroptosis and relieving ischemic stroke." 1 CIRC_0085323 SILENCING INHIBITS TNF-Alpha-INDUCED NORMAL HUMAN COLONIC EPITHELIAL CELL INFLAMMATION AND APOPTOSIS THROUGH THE MIR-495-3P/TRAF3 AXIS. hsa_circ_0085323 - circ_0085323 DOID:8577 ulcerative colitis ulcerative colitis RT-qPCR up-regulated "Circ_0085323 knockdown ameliorated TNF-¦Á-induced NCM460 cell injury by regulating the miR-495-3p/TRAF3 axis, which suggested that circ_0085323 might be a therapeutic target for UC." 2 "Resveratrol alleviates amyloid beta-induced neuronal apoptosis, inflammation, and oxidative and endoplasmic reticulum stress by circ_0050263/miR-361-3p/PDE4A axis during Alzheimer disease." hsa_circ_0050263 - circ_0050263 DOID:10652 Alzheimer disease Alzheimer disease RT-qPCR up-regulated "Res alleviated Abeta-induced neuronal apoptosis, inflammation, oxidative stress, and ERS via circ_0050263/miR-361-3p/PDE4A axis, providing new insights for AD therapy." 1 Downregulation of circAsxl2 Relieves Neuronal Injury Induced by oxygen-glucose deprivation/reperfusion. mmu_circ_0000346 mmu_circ_Asxl2 circAsxl2 DOID:326 ischemia cerebral ischemia-reperfusion (I/R) injury RT-qPCR up-regulated "CircAsxl2/miR-130b-5p/FOXO3 axis accelerated OGD/R-induced neuronal injury, which might provide effective strategies for treating cerebral I/R injury." 1 "Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis." - hsa_circ_UBR4 circ-UBR4 DOID:1936 atherosclerosis atherosclerosis RT-qPCR up-regulated "circ-UBR4 knockdown decreased proliferation, migration, and inflammation but stimulated apoptosis in ox-LDL-induced VSMCs by targeting the miR-515-5p/IGF2 axis." 3 Dietary Morus alba L. leaf supplementation improves hepatic lipid accumulation of laying hens via downregulating CircACACA. - gga_circ_ACACA circACACA DOID:9452 fatty liver disease Fatty liver hemorrhagic syndrome "RT-qPCR, RNA-seq" up-regulated mulberry leaf is an effective therapeutic strategy for FLHS in hens and can improve liver lipid metabolism by downregulating circACACA. 1 CircFLNA/miR-214 modulates regulatory T cells by regulating PD-1 in acute lung injury induced by sepsis. - hsa_circ_FLNA CircFLNA DOID:11394 adult respiratory distress syndrome ARDS RT-qPCR up-regulated circFLNA/miR-214-5p/PD-1 signaling is a novel pathway that modulates Tregs in ARDS. 1 Identification and functional analysis of circRIPK2 in lipopolysaccharide induced chicken macrophages. - gga_circ_RIPK2 circRIPK2 DOID:0040085 bacterial sepsis bacterial infection RT-qPCR up-regulated "This study provides better understanding of the function of_ircRIPK2, which may prove a potential biomarker and indicate potential targets for the treatment of bacterial infection." 1 Circ_0000396 suppresses the proliferation and inflammation of rheumatoid arthritis synovial fibroblasts by targeting miR-574-5p/RSPO1 axis. hsa_circ_0000396 - Circ_0000396 DOID:7148 rheumatoid arthritis rheumatoid arthritis RT-qPCR down-regulated "Circ_0000396 restrained the proliferation and inflammation and induced the apoptosis of RASFs by mediating miR-574-5p/RSPO1 axis, which provided novel potential targets for RA treatment." 2