circRNA basic information
circBase ID: -
Name: hsa_circ_VANGL1
Synonym: circ-VANGL1
Host Gene: hsa-miR-605-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BC cell lines (T24, 253J, UMUC_3, J82, 5637, EJ)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: VANGL1
Associated microRNA: hsa-miR-605-3p
Biological function: promote cell proliferation, cell cycle, migration, and invasion
Molecular mechanism: circ-VANGL1 as a sponge of hsa-miR-605-3p which targeted VANGL1 in BC cells. Through repressing hsa-miR-605-3p availability, circ-VANGL1 contributes to VANGL1 expression, consequently leading to BC cell proliferation, migration, and invasion.
Survival: -
Supported No.:
 3
Description:

The circ-VANGL1/miR-605-3p/VANGL1 as a novel essential signaling pathway involved in BC progression.
Other information
Title:

Circular RNA circ-VANGL1 as a competing endogenous RNA contributes to bladder cancer progression by regulating miR-605-3p/VANGL1 pathway.

Journal: J Cell Physiol
Published: 2018/8/28
PubMed ID: 30146736