circRNA basic information
circBase ID: hsa_circ_0007534
Name: hsa_circ_DDX42
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A human bone cell line (hFOB1.19), OS cell lines (HOS, Saos2, MG63, U2OS)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT/GSK-3beta, Bcl-2/caspase-3
Associated microRNA: -
Biological function: promote cell proliferation and inhibit cell apoptosis
Molecular mechanism: affecting AKT/GSK-3beta signaling pathway
Survival: poor
Supported No.:
 2
Description:

hsa_circ_0007534 protects against cell apoptosis via Bcl-2/caspase-3 pathway. Furthermore, AKT/GSK-3beta pathway could be activated by hsa_circ_0007534 to facilitate OS progression.
Other information
Title:

Overexpression of hsa_circ_0007534 predicts unfavorable prognosis for osteosarcoma and regulates cell growth and apoptosis by affecting AKT/GSK-3beta signaling pathway.

Journal: Biomed Pharmacother
Published: 2018/8/25
PubMed ID: 30142548