circRNA basic information
circBase ID: hsa_circ_0025036
Name: hsa_circ_FOXM1
Synonym: -
Host Gene: hsa-miR-198
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: lung adenocarcinoma cell lines (A549, Calu-3), NHBE, HEK-293T (293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SHMT1, TGF-alpha
Associated microRNA: hsa-miR-198
Biological function: promote cell proliferation and inhibit cell apoptosis
Molecular mechanism: hsa_circ_0025036/hsa-miR-198/SHMT1&TGF-alpha axis
Survival: poor
Supported No.:
 1
Description:

In conclusion, we demonstrate that hsa_circ_0025036 regulates cell proliferation and apoptosis in lung adenocarcinoma cells probably via hsa_circ_0025036/miR-198/SHMT1&TGF-alpha axis. hsa_circ_0025036 may serve as a potential prognostic biomarker and a therapeutic target for lung adenocarcinoma.
Other information
Title:

Aberrant expression of hsa_circ_0025036 in lung adenocarcinoma and its potential roles in regulating cell proliferation and apoptosis.

Journal: Biol Chem
Published: 2018/8/24
PubMed ID: 30138108