circRNA basic information
circBase ID: hsa_circ_0004458
Name: hsa_circ_PSD3
Synonym: -
Host Gene: hsa-miR-885-5p
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human thyroid follicular epithelial cells (Nthy-ori 3-1) cells, PTC cells lines (BCPAP, TPC, K1, IHH4)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RAC1
Associated microRNA: hsa-miR-885-5p
Biological function: promote cells proliferation
Molecular mechanism: Inhibition of hsa-miR-885-5p and Activation of RAC1
Survival: -
Supported No.:
 5
Description:

We found that hsa_circ_0004458 promoted the progression of PTC by inhibition of miR-885-5p and activation of RAC1, and hsa_circ_0004458 may serve as a potential therapeutic target and biomarker for PTC.
Other information
Title:

Upregulated hsa_circ_0004458 Contributes to Progression of Papillary Thyroid Carcinoma by Inhibition of miR-885-5p and Activation of RAC1.

Journal: Med Sci Monit
Published: 2018/8/8
PubMed ID: 30086127