circRNA basic information
circBase ID: -
Name: hsa_circ_EPSTI1
Synonym: circRNA_000479
Host Gene: hsa-miR-4753, hsa-miR-6809
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal mammary epithelial cell lines (MCF-10A,184A1), human breast cancer cell lines (HCC38, HCC1806, BT549, MDA-MB-231, MDA-MB-468, MDA-MB-415, MCF-7, T47D, BT474, Skbr-3), human embryonic kidney cells (HEK 293T cells)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: BCL11A
Associated microRNA: hsa-miR-4753, hsa-miR-6809
Biological function: promoted the proliferation, invasion and inhibited the apoptosis
Molecular mechanism: circEPSTI1 binds to hsa-miR-4753 and hsa-miR-6809 as a miRNA sponge to regulate BCL11A expression and affect TNBC proliferation and apoptosis
Survival: poor
Supported No.:
 1
Description:

The circEPSTI1-miR-4753/6809-BCL11A axis affect the proliferation and apoptosis of triple-negative breast cancer through the mechanism of competing endogenous RNAs (ceRNA). In addition, our results identify circEPSTI1 as an independent prognostic marker for survival in patients with TNBC.
Other information
Title:

circEPSTI1 as a Prognostic Marker and Mediator of Triple-Negative Breast Cancer Progression.

Journal: Theranostics
Published: 2018/8/8
PubMed ID: 30083277