circRNA basic information
circBase ID: -
Name: hsa_circ_NFIX
Synonym: -
Host Gene: hsa-miR-34a-5p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal astrocytes (HA1800), human glioma cell lines (SF-539, SHG-44, U87)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NOTCH1
Associated microRNA: hsa-miR-34a-5p
Biological function: promote propagation and migration
Molecular mechanism: sponging hsa-miR-34a-5p via the Notch signaling pathway.
Survival: -
Supported No.:
 2
Description:

CircNFIX was markedly upregulated in glioma cells. CircNFIX could regulate NOTCH1 and the Notch signaling pathway to promote glioma progression by sponging miR-34a-5p via the Notch signaling pathway. This finding provided a deeper insight into the function of circNFIX in human glioma cancer progression.
Other information
Title:

NFIX Circular RNA Promotes Glioma Progression by Regulating miR-34a-5p via Notch Signaling Pathway.

Journal: Front Mol Neurosci
Published: 2018/8/4
PubMed ID: 30072869