circRNA basic information
circBase ID: -
Name: hsa_circ_IARS
Synonym: circ-IARS
Host Gene: hsa-miR-122
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: ATCC cell lines (HUVEC, Hs 766 T, Aspc-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZO-1, RhoA, RhoA-GTP, F-actin
Associated microRNA: hsa-miR-122
Biological function: promoted tumor invasion and metastasis
Molecular mechanism: down-regulated hsa-miR-122 and ZO-1 levels, up-regulated RhoA and RhoA-GTP levels, increased F-actin expression and focal adhesion, enhanced endothelial monolayer permeability, and promoted tumor invasion and metastasis
Survival: poor
Supported No.:
 1
Description:

Circ-IRAS accesses HUVECs via exosomes derived from pancreatic cancer cells followed by increased endothelial monolayer permeability. Furthermore, this process promotes tumor invasion and metastasis. The results of this study suggest that the presence of circRNAs in exosomes may be important indicator for early diagnosis and prognostic prediction in PDAC.
Other information
Title:

Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis.

Journal: J Exp Clin Cancer Res
Published: 2018/8/2
PubMed ID: 30064461