circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-654
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: glioma cell lines (U87, U251), normal human astrocytes (NHAs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF2BP3
Associated microRNA: hsa-miR-654
Biological function: promote glioma progression
Molecular mechanism: regulating hsa-miR-654/IGF2BP3 signaling.
Survival: poor
Supported No.:
 7
Description:

our findings demonstrated that circHIPK3 contributes to glioma progression through targeting miR-654 from IGF2BP3 and implies circHIPK3 might be a potential target for glioma therapy.
Other information
Title:

CircRNA circHIPK3 serves as a prognostic marker to promote glioma progression by regulating miR-654/IGF2BP3 signaling.

Journal: Biochem Biophys Res Commun
Published: 2018/7/31
PubMed ID: 30057315