circRNA basic information
circBase ID: -
Name: hsa_circ_ITGA7
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CRC cell lines (SW480, RKO, Caco-2, SW620, LoVo, HCT116, DLD1), normal human colonic epithelial cell line (FHC)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
DN
Associated gene: ITGA7, RREB1
Associated microRNA: -
Biological function: inhibits colorectal cancer growth and metastasis
Molecular mechanism: suppressing the Ras signalling pathway and promoting the transcription of ITGA7
Survival: -
Supported No.:
 4
Description:

our findings indicate a suppressor role of circITGA7 and ITGA7 in CRC, and reveal that circITGA7 inhibits the proliferation and metastasis of CRC cells by suppressing the Ras signalling pathway and promoting the transcription of ITGA7, suggesting that circITGA7 is a potential target for CRC treatment.

Other information
Title:

Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7.

Journal: J Pathol
Published: 2018/6/27
PubMed ID: 29943828