circRNA basic information
circBase ID: -
Name: hsa_circ_CBFB
Synonym: circ-CBFB
Host Gene: hsa-miR-607
 
 
 
Disease basic information
DO ID:
 1040
DO name: chronic lymphocytic leukemia
Disease details: chronic lymphocytic leukemia
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FZD3
Associated microRNA: hsa-miR-607
Biological function: promotes proliferation and inhibits apoptosis
Molecular mechanism: By inhibiting hsa-miR-607 availability, circ-CBFB promoted FZD3 expression, leading to the activation of the Wnt/beta-catenin pathway and consequent CLL progression
Survival: poor
Supported No.:
 1
Description:

our findings revealed that the circ-CBFB/miR-607/FZD3/Wnt/beta-catenin regulatory signaling cascade contributes to CLL progression.
Other information
Title:

Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/beta-catenin pathway.

Journal: Biochem Biophys Res Commun
Published: 2018/6/15
PubMed ID: 29902450