circRNA basic information
circBase ID: -
Name: hsa_circ_PRKCI
Synonym: circ-PRKCI
Host Gene: hsa-miR-1324
 
 
 
Disease basic information
DO ID:
 10487
DO name: Hirschsprung disease
Disease details: hirschsprung disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: 293T, SH-SY5Y
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PLCB1
Associated microRNA: hsa-miR-1324
Biological function: promote migration and proliferation
Molecular mechanism: functioned as a molecular sponge for hsa-miR-1324 to upregulate the expression of PLCB1
Survival: -
Supported No.:
 1
Description:

we confirmed that circ-PRKCI functioned as a molecular sponge for miR-1324 to upregulate the expression of PLCB1. In conclusion, our present study revealed the important role of circ-PRKCI-miR-1324-PLCB1 regulatory network in HSCR, providing a novel insight for the pathogenesis of HSCR.
Other information
Title:

Down-regulation of circ-PRKCI inhibits cell migration and proliferation in Hirschsprung disease by suppressing the expression of miR-1324 target PLCB1.

Journal: Cell Cycle
Published: 2018/6/14
PubMed ID: 29895226