circRNA basic information
circBase ID: hsa_circ_0046264
Name: hsa_circ_P4HB
Synonym: -
Host Gene: hsa-miR-1245
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human highly metastasis lung cancer cell line (95-D), common lung cancer cell line (A549), normal human lung cell line (HLF-a), normal human embryonic lung fibroblast line (MRC-5. 95-D, A549)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: BRCA2
Associated microRNA: hsa-miR-1245
Biological function: induced apoptosis but inhibited proliferation and invasion of lung cancer cells
Molecular mechanism: targeting hsa-miR-1245 to up-regulate BRCA2
Survival: -
Supported No.:
 1
Description:

Hsa_circ_0046264 was a tumor suppressor in lung cancer. Overexpression of hsa_circ_0046264 could up-regulate BRCA2 expression through down-regulating of miR-1245.
Other information
Title:

Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245.

Journal: Respir Res
Published: 2018/6/13
PubMed ID: 29891014