circRNA basic information
circBase ID: -
Name: hsa_circ_IBTK
Synonym: -
Host Gene: hsa-miR-29b
 
 
 
Disease basic information
DO ID:
 9074
DO name: systemic lupus erythematosus
Disease details: systemic lupus erythematosus
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: AKT
Associated microRNA: hsa-miR-29b
Biological function: -
Molecular mechanism: inhibits DNA demethylation and activation of AKT signaling pathway via hsa-miR-29b
Survival: -
Supported No.:
 1
Description:

CircIBTK was downregulated in SLE and might regulate DNA demethylation and the AKT signaling pathway via binding to miR-29b in SLE. CircIBTK and miR-29 could also act as biomarkers and therapeutic targets for SLE.
Other information
Title:

CircIBTK inhibits DNA demethylation and activation of AKT signaling pathway via miR-29b in peripheral blood mononuclear cells in systemic lupus erythematosus.

Journal: Arthritis Res Ther
Published: 2018/6/10
PubMed ID: 29884225