circRNA basic information
circBase ID: -
Name: hsa_circ_CCDC66
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: NSCLC cell lines (H125, H23, H226, H838, H1437, H2009, H2087, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FAK, c-Met, nAchR7alpha
Associated microRNA: -
Biological function: -
Molecular mechanism: increase EMT and drug resistance of LADC cells
Survival: -
Supported No.:
 1
Description:

HGF/c-Met regulates expression of SAE2 and cirRNA CCDC66 to increase EMT and drug resistance of LADC cells. Multimodality drugs concurrently aiming at these targets would probably provide more benefits for cancer patients.
Other information
Title:

The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells.

Journal: J Hematol Oncol
Published: 2018/6/2
PubMed ID: 29855336