circRNA basic information
circBase ID: hsa_circ_0002052
Name: hsa_circ_PAPPA
Synonym: -
Host Gene: hsa-miR-1205
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human OS cell lines (HOS, U2OS, MG63, 143B), human osteoblast cell line (hFOB1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: APC2
Associated microRNA: hsa-miR-1205
Biological function: suppressed OS cell proliferation, migration and invasion
Molecular mechanism: suppressed the activation of Wnt/beta-catenin signaling pathway
Survival: better
Supported No.:
 5
Description:

Our study suggested hsa_circ_0002052/miR-1205/APC2/Wnt/beta-catenin axis might be a potential target for OS therapy.
Other information
Title:

Overexpressing circular RNA hsa_circ_0002052 impairs osteosarcoma progression via inhibiting Wnt/beta-catenin pathway by regulating miR-1205/APC2 axis.

Journal: Biochem Biophys Res Commun
Published: 2018/6/1
PubMed ID: 29852168