circRNA basic information
circBase ID: -
Name: hsa_circ_ZRANB1
Synonym: -
Host Gene: hsa-miR-217
 
 
 
Disease basic information
DO ID:
 8466
DO name: retinal degeneration
Disease details: retinal neurodegeneration
Species: human
Species details: human
Sample type: cell line
Sample type details: retinal glial cells line (rMC-1), primary RGCs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RUNX2
Associated microRNA: hsa-miR-217
Biological function: cZRANB1 knockdown decreases retinal reactive gliosis, glial cell activation, and facilitates RGC survival
Molecular mechanism: participate in cZRANB1/hsa-miR-217/RUNX2 network
Survival: -
Supported No.:
 1
Description:

cZRANB1 acts as miRNA sponge to regulate M¨šller cell function through cZRANB1/miR-217/RUNX2 network. Intervention of cZRANB1 expression would become an effective strategy for treating retinal neurodegeneration.
Other information
Title:

Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration.

Journal: Cell Death Dis
Published: 2018/5/12
PubMed ID: 29748605