circRNA basic information
circBase ID: -
Name: -
Synonym: circ0006916
Host Gene: hsa-miR-522-3p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human lung cancer cells (A549, H460)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: PHLPP1, TNRC6A
Associated microRNA: hsa-miR-522-3p
Biological function: inhibite cell proliferation and promoting apoptosis
Molecular mechanism: bound to hsa-miR-522-3p and inhibited pleckstrin homology domain and leucine rich repeat protein phosphatase 1 (PHLPP1) activity
Survival: -
Supported No.:
 1
Description:

These results demonstrate that TNRC6A regulates the biogenesis of the circRNA circ0006916, which has a regulatory role in cell growth.
Other information
Title:

RNA-binding protein trinucleotide repeat-containing 6A regulates the formation of circular RNA circ0006916, with important functions in lung cancer cells.

Journal: Carcinogenesis
Published: 2018/5/5
PubMed ID: 29726904