circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9952
DO name: acute lymphoblastic leukemia
Disease details: acute lymphoblastic leukemia
Species: human
Species details: human
Sample type: cell line
Sample type details: immortalized normal human gastric cell line (GES-1, Nalm-6 B-ALL), immortalized normal human liver cell line (LO2), hepatoma cell lines (BEL-7402, Hep3B, HepG2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: c-Myc, Bcl-2
Associated microRNA: -
Biological function: promote cell proliferation, but suppress cell apoptotic
Molecular mechanism: target its neighbor gene c-Myc, and antiapoptotic Bcl-2 protein expression
Survival: -
Supported No.:
 2
Description:

CircPVT1 is upregulated in ALL. Silencing circPVT1 results in cell growth arrest and apoptosis of the cells. Our results also suggested a therapeutic potential of targeting circPVT1 in ALL.
Other information
Title:

Circular RNA PVT1 expression and its roles in acute lymphoblastic leukemia.

Journal: Epigenomics
Published: 2018/4/26
PubMed ID: 29693417