circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human osteosarcoma cell lines (SaoS2, KHOS, U2OS, MG63)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ABCB1
Associated microRNA: -
Biological function: contributes to doxorubicin and cisplatin resistance of osteosarcoma cells
Molecular mechanism: circPVT1 knockdown by siRNA could weaken the resistance to doxorubicin and cisplatin of OS cells through decreasing the expression of classical drug resistance-related gene ABCB1
Survival: poor
Supported No.:
 5
Description:

These findings may provide a new insight into the role of circPVT1 as a biomarker for the diagnosis and treatment target of OS.
Other information
Title:

Overexpressed circPVT1, a potential new circular RNA biomarker, contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1.

Journal: Int J Biol Sci
Published: 2018/3/22
PubMed ID: 29559849