circRNA basic information
circBase ID: -
Name: hsa_circ_GRB10
Synonym: -
Host Gene: hsa-miR-328-5p
 
 
 
Disease basic information
DO ID:
 90
DO name: degenerative disc disease
Disease details: intervertebral disc degeneration
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: ErbB pathway
Associated microRNA: hsa-miR-328-5p
Biological function: inhibited NP cell apoptosis
Molecular mechanism: sequester hsa-miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway
Survival: -
Supported No.:
 3
Description:

the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD.
Other information
Title:

Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk.

Journal: Cell Death Dis
Published: 2018/2/25
PubMed ID: 29476072