circRNA basic information
circBase ID: -
Name: hsa_circ_FLNA
Synonym: CircFLNA
Host Gene: hsa-miR-214-5p
 
 
 
Disease basic information
DO ID:
 11394
DO name: adult respiratory distress syndrome
Disease details: ARDS
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PD-1
Associated microRNA: hsa-miR-214-5p
Biological function: circFLNA was aberrantly elevated in ARDS, and depletion of circFLNA upregulated CD4+CD25+Foxp3+_regs and decreased inflammatory response.
Molecular mechanism: miR-214-5p which binds with circFLNA, reversed circFLNA-induced effects in ARDS. Programmed cell death protein 1 (PD-1) is a downstream target gene of miR-214-5p, and abrogated the effects of miR-214-5p on regulating CD4+CD25+Foxp3+_regs and inflammatory response.
Survival: -
Supported No.:
 1
Description:

circFLNA/miR-214-5p/PD-1 signaling is a novel pathway that modulates Tregs in ARDS.
Other information
Title:

CircFLNA/miR-214 modulates regulatory T cells by regulating PD-1 in acute lung injury induced by sepsis.

Journal: Autoimmunity
Published: 2023/9/19
PubMed ID: 37724530