circRNA basic information
circBase ID: -
Name: hsa_circ_UBR4
Synonym: circ-UBR4
Host Gene: hsa-miR-515-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: vascular smooth muscle cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF2
Associated microRNA: hsa-miR-515-5p
Biological function: ox-LDL stimulated proliferation, migration, and inflammation but decreased apoptosis in VSMCs, which were overturned by the inhibition of circ-UBR4.
Molecular mechanism: miR-515-5p was sponged by circ-UBR4, and its inhibitor reversed the inhibitory effect of circ-UBR4 knockdown on proliferation, migration, and inflammation in ox-LDL-induced VSMCs.
Survival: -
Supported No.:
 3
Description:

circ-UBR4 knockdown decreased proliferation, migration, and inflammation but stimulated apoptosis in ox-LDL-induced VSMCs by targeting the miR-515-5p/IGF2 axis.
Other information
Title:

Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis.

Journal: Open Med (Wars)
Published: 2023/9/11
PubMed ID: 37693837