circRNA basic information
circBase ID: -
Name: hsa_circ_BBS2
Synonym: circBBS2
Host Gene: hsa-miR-494
 
 
 
Disease basic information
DO ID:
 3526
DO name: cerebral infarction
Disease details: ischemic stroke
Species: human
Species details: human
Sample type: cell line
Sample type details: SH-SY5Y cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SLC7A11
Associated microRNA: hsa-miR-494
Biological function: circBBS2 was lowly expressed and ferroptosis was triggered in MCAO rats and H/R-stimulated SH-SY5Y cells. UC-MSCs-derived exosomes enhanced cell viability and restrained ferroptosis via increasing circBBS2 expression in SH-SY5Y cells.
Molecular mechanism: circBBS2 sponged miR-494 to enhance the SLC7A11 level. Knockdown of miR-494 or SLC7A11 reversed the effects of silencing circBBS2 or miR-494 on ferroptosis of SH-SY5Y cells, respectively.
Survival: -
Supported No.:
 1
Description:

UC-MSCs-derived exosomal circBBS2 enhanced SLC7A11 expression via sponging miR-494, therefore repressing ferroptosis and relieving ischemic stroke.
Other information
Title:

Exosomal circBBS2 inhibits ferroptosis by targeting miR-494 to activate SLC7A11 signaling in ischemic stroke.

Journal: FASEB J
Published: 2023/8/21
PubMed ID: 37603538