circRNA basic information
circBase ID: hsa_circ_0003575
Name: -
Synonym: Circ_0003575
Host Gene: hsa-miR-637
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HAECs (ATCC, Manassas, VA, USA)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRAF6
Associated microRNA: hsa-miR-637
Biological function: Circ_0003575 knockdown promoted the proliferation and angiogenesis and repressed apoptosis and inflammation in ox-LDL-treated HAECs
Molecular mechanism: Circ_0003575 directly targeted miR-637,TRAF6 was targeted by miR-637
Survival: -
Supported No.:
 3
Description:

Circ_0003575 knockdown alleviated ox-LDL-induced HAEC damage by regulating miR-637/TRAF6 and NF-¦ĘB pathways.
Other information
Title:

Circ_0003575 knockdown alleviates ox-LDL-induced human aortic endothelial cell dysfunction in atherosclerosis by miR-637/TRAF6 axis.

Journal: Clin Hemorheol Microcirc
Published: 2023/8/21
PubMed ID: 37599528