circRNA basic information
circBase ID: -
Name: hsa_circ_LDLRAD3
Synonym: CircLDLRAD3
Host Gene: hsa-miR-558
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: squamous carcinoma cell lines (CAL27, SCC9, SCC15), human normal oral epithelial keratinocytes (HOK)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: Smad4
Associated microRNA: hsa-miR-558
Biological function: CircLDLRAD3 inhibits proliferation, migration, and invasion of OSCC cells both in vitro and in vivo.
Molecular mechanism: circLDLRAD3/hsa-miR-558/Smad4 axis, miRNA sponge, TGF-beta signalling pathways
Survival: -
Supported No.:
 1
Description:

Our study found that circLDLRAD3 is downregulated in OSCC and verified its tumour suppressor function and mechanism in OSCC through sponging miR-558 to regulate miR-558/Smad4/TGF-beta axis.
Other information
Title:

CircLDLRAD3 inhibits Oral squamous cell carcinoma progression by regulating miR-558/Smad4/TGF-beta

Journal: J Cell Mol Med
Published: 2023/8/10
PubMed ID: 37563869