circRNA basic information
circBase ID: -
Name: hsa_circ_MKLN1
Synonym: CircMKLN1
Host Gene: hsa-miR-26a-5p
 
 
 
Disease basic information
DO ID:
 8947
DO name: diabetic retinopathy
Disease details: Diabetic retinopathy
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Rab11a
Associated microRNA: hsa-miR-26a-5p
Biological function: CircMKLN1-silencing treatment reduces HG/MG-related reactive autophagy and inflammation.
Molecular mechanism: circMKLN1 adsorbs miR-26a-5p as a molecular sponge and mediates high glucose (HG)/methylglyoxal (MG)-induced autophagy in hRMECs.
Survival: -
Supported No.:
 1
Description:

CircMKLN1-silencing treatment reduces HG/MG-related reactive autophagy and inflammation. In addition, miR-26a-5p targeting by circMKLN1 plays an important role in the regulation of Rab11a expression. Thus, either new biomarkers or new therapeutic targets may be identified with the translation of these findings.
Other information
Title:

The circRNA MKLN1 regulates autophagy in the development of diabetic retinopathy.

Journal: Biochim Biophys Acta Mol Basis Dis
Published: 2023/8/8
PubMed ID: 37549719