circRNA basic information
circBase ID: hsa_circ_0002131
Name: -
Synonym: Circ_0002131
Host Gene: hsa-miR-942-5p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: cell line
Sample type details: HK-2 cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: OXSR1
Associated microRNA: hsa-miR-942-5p
Biological function: LPS-induced apoptosis, inflammation and oxidative injury of HK-2 cells were attenuated after silence of circ_0002131.
Molecular mechanism: circ_0002131 targeted miR-942-5p to elevate OXSR1 expression. MiR-942-5p prevented LPS-evoked HK-2 cell injury via targeting OXSR1.
Survival: -
Supported No.:
 1
Description:

circ_0002131 promoted LPS-mediated HK-2 cell injury via miR-942-5p-mediated upregulation of OXSR1, suggesting that circ_0002131/miR-942-5p/OXSR1 axis was related to sepsis-induced AKI progression.
Other information
Title:

Circ_0002131 contributes to LPS-induced apoptosis, inflammation and oxidative injury in HK-2 cells via inhibiting the binding between miR-942-5p and OXSR1.

Journal: Shock
Published: 2023/8/7
PubMed ID: 37549022