circRNA basic information
circBase ID: -
Name: hsa_circ_TDRD9
Synonym: circTDRD9
Host Gene: hsa-miR-223-3p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: acute lung injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A549 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RAB10
Associated microRNA: hsa-miR-223-3p
Biological function: CircTDRD9 downregulation prevented LPS-induced inflammation, oxidative stress, cell proliferation inhibition, and cell fibrosis in A549 cells, whereas these effects were reversed by the inhibition of miR-223-3p, a target of circTDRD9.
Molecular mechanism: RAB10 was verified as a target of miR-223-3p, and RAB10 overexpression recovered LPS-induced inflammation, oxidative stress, cell proliferation inhibition, and cell fibrosis in A549 cells that were ameliorated by miR-223-3p restoration.
Survival: -
Supported No.:
 1
Description:

CircTDRD9 overexpression was closely associated with LPS-induced ALI. CircTDRD9 contributed to LPS-induced ALI partly by upregulating RAB10 via binding to miR-223-3p.
Other information
Title:

Circtdrd9 Contributes to Sepsis-Induced Acute Lung Injury by Enhancing the Expression of Rab10 Via Directly Binding to Mir-223-3p.

Journal: Shock
Published: 2023/8/7
PubMed ID: 37548713