circRNA basic information
circBase ID: -
Name: hsa_circ_AEBP2
Synonym: circRNA_0006420
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A549, H1299
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: HUR, PTBP1
Associated microRNA: -
Biological function: Knockdown of circRNA_0006420 in A549 cells only reduced cell viability
Molecular mechanism: circRNA_0006420/HUR/PTBP1 complex
Survival: -
Supported No.:
 1
Description:

Lung cancer cells retaining p53 may upregulate circRNA_0006420 (IRSense) expression post radiation to form an IRSense/HUR/PTBP1 complex leading to radiotherapy resistance
Other information
Title:

P53-response circRNA_0006420 aggravates lung cancer radiotherapy resistance by promoting formation of HUR/PTBP1 complex

Journal: J Adv Res
Published: 2023/8/2
PubMed ID: 37541584