circRNA basic information
circBase ID: hsa_circ_0000157
Name: -
Synonym: circ_0000157
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 3083
DO name: chronic obstructive pulmonary disease
Disease details: COPD
Species: human
Species details: human
Sample type: cell line
Sample type details: 16HBE
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BRD4
Associated microRNA: hsa-miR-149-5p
Biological function: CSE treatment inhibited 16HBE cell proliferation and induced cell apoptosis, inflammation, and oxidative stress; however, these effects were remitted when circ_0000157 expression was decreased.
Molecular mechanism: circ_0000157 acted as a miR-149-5p sponge and regulated CSE-caused 16HBE cell damage by targeting miR-149-5p. The overexpression of BRD4, a target gene of miR-149-5p, attenuated the inhibitory effects of miR-149-5p introduction on CSE-induced cell damage.
Survival: -
Supported No.:
 1
Description:

Circ_0000157 knockdown ameliorated CSE-caused 16HBE cell damage by targeting the miR-149-5p/BRD4 pathway, providing a potential therapeutic strategy for clinic intervention in COPD.
Other information
Title:

Circular RNA 0000157 depletion protects human bronchial epithelioid cells from cigarette smoke extract-induced human bronchial epithelioid cell injury through the microRNA-149-5p/bromodomain containing 4 pathway.

Journal: Hum Exp Toxicol
Published: 2023/8/3
PubMed ID: 37533154