circRNA basic information
circBase ID: -
Name: hsa_circ_RIMS
Synonym: CircRIMS
Host Gene: hsa-miR-96-5p
 
 
 
Disease basic information
DO ID:
 326
DO name: ischemia
Disease details: cerebral ischemia-reperfusion injury
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: OGD/RX-simulated cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: JAK, STAT1
Associated microRNA: hsa-miR-96-5p
Biological function: Knockdown circRIMS demonstrated the functional of circRIMS in increasing cell viability, reducing apoptosis, LDH activity and inflammatory factors secretion in OGD/RX-simulated CIR injury in vitro.
Molecular mechanism: miR-96-5p was identified as a target of circRIMS, while the_TAT1_ene is a downstream gene of miR-96-5p, and_AK_as also considered to be a downstream gene of the JAK-STAT pathway.
Survival: -
Supported No.:
 1
Description:

CircRIMS contributes to the progression of CIR injury via regulating miR-96-5p/JAK/STAT1 axis.
Other information
Title:

CircRIMS promotes cerebral ischemia-reperfusion injury through increasing apoptosis and targeting the miR-96-5p/JAK/STAT1 axis.

Journal: Brain Inj
Published: 2023/7/29
PubMed ID: 37515578