circRNA basic information
circBase ID: hsa_circ_0035292
Name: -
Synonym: circ_0035292
Host Gene: hsa-miR-494-3p
 
 
 
Disease basic information
DO ID:
 552
DO name: pneumonia
Disease details: pneumonia
Species: human
Species details: human
Sample type: cell line
Sample type details: WI-38 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TLR4
Associated microRNA: hsa-miR-494-3p
Biological function: Silenced circ_0035292 could enhance WI-38 cell proliferation, while suppress apoptosis, inflammation and oxidative stress under LPS treatment.
Molecular mechanism: circ_0035292 targeted miR-494-3p to positively regulate TLR4. The rescue experiments indicated that miR-494-3p inhibitor abolished the function of circ_0035292 knockdown, and TLR4 overexpression reversed the inhibitory effect of miR-494-3p on LPS-induced WI-38 cell injury.
Survival: -
Supported No.:
 3
Description:

Circ_0035292 might be a potential target for infantile pneumonia treatment, which knockdown could relieve LPS-induced cell injury via the regulation of miR-494-3p/TLR4 axis.
Other information
Title:

Downregulation of circ_0035292 Alleviates LPS-Induced WI-38 Cell Injury via Targeting miR-494-3p/TLR4 Pathway in Infantile Pneumonia.

Journal: Biochem Genet
Published: 2023/7/28
PubMed ID: 37500967