circRNA basic information
circBase ID: hsa_circ_0057105
Name: hsa_circ_PDK1
Synonym: -
Host Gene: hsa-miR-577
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal kidney cell lines (HK2, 293), RCC cell lines (Caki_1, A498,769P, 786_O)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: COL1A1, VDAC2
Associated microRNA: hsa-miR-577
Biological function: Hsa_circ_0057105 expression was associated with advanced TNM stages and was an independent prognostic factor for poor RCC patient survival. Phenotypic studies show that hsa_circ_0057105 can enhance the migration and invasion abilities of RCC cells
Molecular mechanism: hsa_circ_0057105/hsa-miR-577/COL1A1/VDAC2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In RCC, hsa_circ_0057105 regulates COL1A1 and VDAC2 expression through its sponge effect on miR_577, acting like a ¡®double_edged sword¡¯.
Other information
Title:

Hsa_circ_0057105 modulates a balance of epithelial-mesenchymal transition and ferroptosis vulnerability in renal cell carcinoma

Journal: Clin Transl Med
Published: 2023/7/26
PubMed ID: 37496319