circRNA basic information
circBase ID: -
Name: hsa_circ_Shank3
Synonym: circ-Shank3
Host Gene: hsa-miR-140-3p
 
 
 
Disease basic information
DO ID:
 1561
DO name: cognitive disorder
Disease details: postoperative cognitive dysfunction
Species: human
Species details: human
Sample type: cell line
Sample type details: microglia BV-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TLR4
Associated microRNA: hsa-miR-140-3p
Biological function: silenced circ-Shank3 further reduced TLR4, p65 and Iba-1 and CD11b levels in LPS-treated BV2 cells in the presence of Dex, whereas these phenomena were reversed by miR-140-3p inhibitor.
Molecular mechanism: circ-Shank3 harbor miR-140-3p, functioning as a miRNA sponge, and then miR-140-3p targeted the 3-UTR of TLR4.
Survival: -
Supported No.:
 1
Description:

Collectively, our results found that Dex could attenuate the neuroinflammation and microglia activation in BV2 cells exposed to LPS via targeting circ-Shank3/miR-140-3p/TLR4 axis.
Other information
Title:

Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis.

Journal: Eur J Histochem
Published: 2023/7/26
PubMed ID: 37491974