circRNA basic information
circBase ID: -
Name: hsa_circ_NFKB1
Synonym: circ-NFKB1
Host Gene: hsa-miR-203a-5p.
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: Osteoarthritis
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
RNA-Seq
Detected method confidence Low
Expression pattern:
UP
Associated gene: ERBB4
Associated microRNA: hsa-miR-203a-5p.
Biological function: Silencing of circ-NFKB1 notably inhibited the IL-1beta induced chondrocytes apoptosis and upregulated ERBB4 expression.
Molecular mechanism: miR-203a-5p was the target binding circ-NFKB1, and ERBB4 was the potential target of miR-203a-5p.
Survival: -
Supported No.:
 2
Description:

Silencing circ-NFKB1 could sponge miR-203a-5p to regulate ERBB4 expression and alleviate OA progression.
Other information
Title:

Circ-NFKB1 sponges miR-203a-5p to regulate ERBB4 expression and promotes IL-1beta induced chondrocytes apoptosis.

Journal: J Orthop Surg Res
Published: 2023/7/26
PubMed ID: 37491357