circRNA basic information
circBase ID: -
Name: hsa_circ_SLC4A7
Synonym: circSLC4A7
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human gastric epithelial cell line (GES-1), multiple GC cell lines (AGS, BGC823, MGC803, SGC7901)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HSP90
Associated microRNA: -
Biological function: circSLC4A7 increased CSC-like properties and drove cell proliferation, migration, and invasion, which were determined by gain- and loss-of-function experiments
Molecular mechanism: NOTCH1 signaling pathway
Survival: -
Supported No.:
 1
Description:

This study highlights a novel oncogenic function of circSLC4A7 mediated by its binding with HSP90 and thus activating the Notch1 signaling pathway.
Other information
Title:

circSLC4A7 accelerates stemness and progression of gastric cancer by interacting with HSP90 to activate NOTCH1 signaling pathway

Journal: Cell Death Dis
Published: 2023/7/20
PubMed ID: 37474578