circRNA basic information
circBase ID: hsa_circ_0004771
Name: hsa_circ_NRIP1
Synonym: -
Host Gene: hsa-miR-515-5p
 
 
 
Disease basic information
DO ID:
 4607
DO name: biliary tract cancer
Disease details: biliary tract cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: One normal biliary epithelial cell line (HIBEC), four human BTC cell lines (CCLP-1, QBC939, RBE, HCCC-9810)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT2
Associated microRNA: hsa-miR-515-5p
Biological function: We observed that knockdown of circ_NRIP1 significantly inhibited tumor cell proliferation, invasion, stemness maintenance, and epithelial-mesenchymal transition, indicating its active involvement in promoting BTC progression
Molecular mechanism: circ_NRIP1/hsa-miR-515-5p/AKT2 axis, miRNA sponge, PI3K/AKT/mTOR signaling pathway
Survival: -
Supported No.:
 1
Description:

Generally, targeting the circ_NRIP1/miR-515-5p/AKT2 axis and aberrant activation of the PI3K/AKT/mTOR pathway may hold promising therapeutic strategies for BTC.
Other information
Title:

Circular RNA nuclear receptor interacting protein 1 promoted biliary tract cancer epithelial-mesenchymal transition and stemness by regulating the miR-515-5p/AKT2 axis and PI3K/AKT/mTOR signaling pathway

Journal: Environ Toxicol
Published: 2023/7/19
PubMed ID: 37466171